Search

Objective: In this work, a gastro-retentive floating microsphere delivery system composed of Drug/Glyceryl mono-oleate (GMO) embedded in a Ca-alginate gas-generated matrix was designed to improve the bioavailability of a slightly-soluble model drug Famotidine. Methods: The water/Oil emulsion method was used to prepare Famotidine floatable microspheres, and formulation variables such as Alginate: GMO ratio, gas-generated bicarbonates concentration, and loading drug concentration were investigated. Conventional techniques, including DSC, XRD and FTIR were performed to confirm Famotidine compatibility with GMO and Alginate polymers. Real-Time X-ray Radiography was used for in vivo imaging of Famotidine floatable microspheres using rabbits as an animal model. HPLC spectroscopic technique was used to determine Famotidine plasma concentration after oral administration of Alginate-GMO loaded microspheres. Results: Floating Famotidine Alginate-GMO microspheres (0.75:1:0.25) w/w/w showed a remarkable entrapment efficiency (>98%), good buoyancy (>84) and prolonged in vitro drug release properties (>24 hours). DSC, XRD, and FTIR techniques showed no evidence of interaction between Famotidine and Alginate or GMO. In vivo Imaging of Famotidine floatable microspheres showed that capsules containing Famotidine-Alginate microspheres were not detected after 3 h of administration, while capsules containing Famotidine-GMO-Alginate microspheres can be detected for more than 12 h, indicating superior gastric retention properties. The pharmacokinetic parameters were calculated for Famotidine: GMO-Alginate, and Famotidine: alginate and compared with the plain drug over 24 h period. Famotidine: GMO-Alginate microspheres exhibited controlled and prolonged absorption Tmax of 6.0 vs. 3.0 and 2.0 h; Cmax of 124.9±0.9 vs. 323.7±0.4and 458.6±0.5 ng/ml; AUC0-24 of 2153.025±6.7 vs. 1650.4±1.9 and 1110.725±2.1 ng/ml for Famotidine: alginate and plain drug, respectively, reflecting the increase in the bioavailability of the drug in the floating formulations compared to the free drug. Conclusion: Prolonged gastric retention time and sustained release properties of floating GMO-alginate microsphere suggest that it could provide a valuable sustained release dosage form of slightly-soluble drugs.

This study was carried out during 2021 growing season at the private rain-fed irrigated system vineyard on two cultivars of grapevine (Rashmiree and White Sadany) and chosen vines were 20 years old, and trained by head system a field experiment was located Shar-Bazher at Wazha village, Sulaimani Governorate, Kurdistan Region, Iraq, to investigate the impact of three different pollinators (Taify, Doshawy, and Trerash) as pollinators (pollen donors) and the control (self-pollination) vines provided no yield on some vegetative growth, yield and chemical characteristics of two grape cultivars. The effect of cultivars, Rashmiree obtained significant influence in (bunch weight, width, weight of 100 berries, and volume of 100 berries) characters, but Sadany gave only in maximum bunch width, in other properties there were nonsignificant differences between cultivars. The Bunch weight, Bunch length, bunch width, and the number of berries per bunch were high significant when Rashmiree cultivar pollinate with Trerash pollinator. While the T.S.S%, Total sugar, lowest in TA% and seeds per berry were high significant when Sadany cultivar pollinate with Trerash pollinator. Rashmiree cultivar gave high significant in TA%, and minimum in T.S.S%, total sugar, and number of seeds per berry when pollinated with Taify pollinator.

اصبحت الجرائم الاقتصادية (الجريمة المنظمة ) ظاهرة دولية متنامية وخطيرة ، اثارت الرأي العام والمجتمع الدولي والباحثيين الاقتصاديين ، هذا الموضوع يعتبر من التخصصات الاقتصادية والقانونية والاجتماعية الحديثة والمهمة وخاصة في القرن الواحد والعشرون ، والانتشار السريع لهذه الجرائم والاثار السلبية التي تخلفها (من هدر للموارد الاقتصادية ) ، جعلت الدول والمؤسسات والمنظمات الدولية عاجزة عن معرفة الحجم الفعلي لهذه الجرائم ومعرفة اساليبها وكيفية مكافحتها والقضاء عليها ، وعليه ركزت الدراسات والبحوث العلمية حول هذه المجال ، ولذلك تهدف هذه الدراسة الى دراسة بعض الجرائم الاقتصادية وبيان اثرها في النمو الاقتصادي في المكسيك ، يتم بداية السرد النظري للجرائم الاقتصادية واسباب انتشارها واثارها وبيان انواعها (جريمة الاتجار بالمخدرات غير المشروعة والاتجار غير المشروع بالاسلحة ،الاتجار بالبشر ، غسيل الاموال ) والتي تعتبر الجزء الغير الشرعي من الاقتصاد الغير الرسمي ، والتي لا تدخل ضمن حسابات الناتج المحلي الاجمالي وذلك لانها جرائم تتميز بالسرية وتتم في الخفاء ، وبالتالي يصعب رصدها وقياسها ، ومن ثم السرد الجانب النظري للنمو الاقتصادي والدراسات السابقة ، واخيرا يتم التطرق الى الجانب التطبيقي (الانموذج القياسي) ومن خلال معدلات النمو لمتغيرات الانموذج ، وتم اختيار المتغير المعتمد (النمو الاقتصادي ) لمعرفة مدى الضرر التي يلحق بالموارد الاقتصادية والنمو الاقتصادي ، و المتغير المستقل الجرائم الاقتصادي (الاتجار بالمخدرات غير المشروعة، والاتجار بالبشر ، وغسيل الاموال) وهي تعتبر هدر للموارد الاقتصادية المتاحة النادرة ، وبأفتراض ان العلاقة عكسية بين المتغير المعتمد والمتغير المسقل ، عينة الدراسة (دولة المكسيك) وللفترة المحدودة (2020-2000) والاعتماد على بيانات المنشورة في (W.B.)(DATAUNODC) (FATF) (UIF)، وقد توصلت الدراسة مجموعة من الاستنتاجات منها : غياب تعريف موحد للجرائم الاقتصادية ، لخصائصه العديدة وظهور

Ethanol extracts of Caulerpa racemosa, Dictyopteris acrostichoides, Halimeda opuntia and Polycladia myrica, were tested for their cytotoxicity against HepG2 (human hepatoma), MCF-7 (human breast adenocarcinoma), and Caco-2 (human colon adenocarcinoma) cells. Dictyopteris acrostichoides displayed cytotoxicity against HepG2, MCF-7 and Caco-2 with IC50 values of 11.65, 9.28 and 16.86 µg/mL, respectively in comparison to doxorubicin as a positive control, (IC50 = 5.72, 5.17 and 5.81 µg/mL, respectively). LC-HR-ESI-MS metabolic profiling of the D. acrostichoides extract characterized seventeen metabolites (1–17). In silico analysis indicated 1-(3-oxo-undecyldisulfanyl)-undecan-3-one (16) was the most active EGFR inhibitor, while 1-(3-Oxo-undecyldisulfanyl)-undecan-3-one (16) and di(3-acetoxy-5-undecenyl) disulfide (17) were the most active VEGFR inhibitors. Furthermore, the ethanol extract of D. acrostichoides was tested against epidermal growth factor receptor (EGFR) kinase (IC50 = 0.11 µg/mL) compared to lapatinib as a positive control, (IC50 = 0.03µg/mL) and against vascular endothelial growth factor (VEGF) (IC50 = 0.276 µg/mL) compared to sorafenib as a positive control, (IC50 = 0.049 µg/mL).

The article is devoted to the classification based on the thematic principle of the units of the Russian terminological system of the oil and gas industry and the peculiarities of the functioning of terms in different types of discourse. As a result, the author's typology of terms in the oil and gas sector is presented, examples are given that reflect the functioning of terms in the communicative space of scientific and mass-media discourses.

Background: Endometriosis is the presence of endometrial-like tissue outside the uterus, which induces a chronic, inflammatory reaction. Some women with endometriosis experience painful symptoms and/or infertility, others have no symptoms at all. The aim of this study was to detect the incidence of endometriosis among symptomatic and asymptomatic cases of primary infertility in Tanta University Hospital over one year. Methods: This prospective observational study was conducted on 50 females aged between 20 and 35 years old, with unexplained infertility, symptoms of endometriosis and infertility for 1 or more years. Patients were divided into two equal groups: group (1): cases with unexplained infertility for 1 year or more and group (2): cases with symptoms of primary infertility and endometriosis for 1 year or more. Patients were subjected to the following: meticulous history taking (personal, obstetric and menstrual history, history of present illness, past history 'medical and surgical'), thorough clinical examination, routine laboratory investigations, imaging techniques (ultrasound and HSG) and laparoscopy for diagnosis of possible presence of endometriosis. Results: Endometrioma size was significantly higher in group 2 compared to group 1 (P value = 0.020). Stage 1 of endometriosis was significantly lower in group 2 compared to group 1 and Stage 2, 3 and 4 of endometriosis were significantly higher in group 2 compared to group 1 (P value = 0.04). Dysmenorrhea of endometriosis after treatment were significantly higher in group 2 compared to group 1(P value

One of the most severe problems with flexible asphalt pavements is permanent deformation in the form of rutting. Accordingly, the practice of adding fiber elements to asphalt mix to improve performance under dynamic loading has grown significantly in order to prevent rutting distress and ensure a safe and long-lasting road surface. This paper explores the effects of a combination of ceramic fiber (CF), a low-cost, easily available mineral fiber, and thermal insulator fiber reinforced to enhance the Marshall properties and increase the rutting resistance of asphalt mixes at high temperatures. Asphalt mixtures with 0%, 0.75%, 1.5%, and 2.25% CF content were prepared, and Marshall stability and wheel tracking tests were employed to study the effect of added CF on asphalt mixture performance. Scanning electron microscopy (SEM) and field emission scanning electron microscopy (FESEM) were also used to investigate the morphologies of CF and reinforced asphalt mixtures and to identify the mechanism of improvement .According to the study results, the ideal ceramic fiber content was 1.5%, which yielded an improve in Marshall stability and reduced rut depth by 22.05% and 27.71% at temperatures of 50°C and 60°C, respectively, when compared to asphalt mixtures without CF. Microscopic analyses clearly revealed the surface properties, particle diameter size, and fiber distribution of the reinforced mixture, including the network structure and strength mechanism, which improved the performance of the asphalt mixture by forming a three-dimensional network.

Almost four billion people in the world use the internet which includes forms of social media such as Facebook, Twitter, Instagram, Reddit, etc. Along with the gifts of such developed communication technologies, many hardships and future problems have emerged. Misinformation leaks, internet trolls, and the newer trend of cyber-nationalism all come with these advanced forms of technology. The purpose of this paper is to define what these negative consequences mean for us, and what our government is doing with this new power. To be able to grasp a scope of what is happening, the history of the internet and cyber-nationalism need to be distinguished as well as showing different forms of use and how they affect us in our daily lives. Looking through the eyes of a political geographer it is important to see if cyber-nationalism deserves its own category yet as a topic of study, and how this is similar or different to the use of propaganda in the past such as World War II. This paper concludes with final thoughts on the internet and cyber-nationalism, and future research possibilities that help to interpret the use of cyber-nationalism and further its study.

The performance of the pavement in terms of vehicle safety and tire wear is affected by the friction behavior of the pavement. To highlight the main characteristics that affect the production of better friction resistance of the pavement surface in this work. The micro-texture and macro-texture of the asphalt surface of Baghdad Airport highway were studied using two methods: (sand patch method and the British pendulum test). The sand patch was examined by drawing sand grains of a specific volume, while the micro-texture was analyzed using a BPT under dry and wet surface conditions. All data obtained from the two examinations were analyzed and modelled statistically using SPSS 25 software. Results show that skid resistance of pavement surface increase with the increase of MTD, this increase may be due to the increase of coarse aggregate which lead to increase the roughness of the pavement surface, this increase ranged between (96 - 91%). MTD decreases with the increase of traffic flow due to the friction between the road surface and the vehicle tires leading to increase of smoothness of the road surface. This is mean that MTD is highly affected by the traffic flow and this effectiveness ranged between (84-97%). Skid resistance also is highly affected by the traffic flow with an effectiveness ranged between (81-94%) for both pavement conditions. According to the regression analysis for friction and other parameters, it can be concluded that surface friction values are highly affected by cumulative traffic (asphalt mix deterioration) over time. Doi: 10.28991/cej-2021-03091775 Full Text: PDF

Background: Bleeding from esophageal and gastric varices is a fatal event in patients with liver cirrhosis and portal hypertension. Objective: Evaluation the correlation between Helicobacter Pylori infection and risk of esophagogastric variceal bleeding in liver cirrhosis. Patients and Methods: This study was carried out on one hundred (100) patients, suffering from post hepatitic cirrhosis and portal hypertension: fifty (50) of them presented with esophageogastric varices without bleeding selected from patients coming for screening of esophagogastric varices for anti-hepatitis c virus treatment, and the other fifty (50) presented with acute variceal bleeding. All patients attending to Internal Medicine outpatient’s clinic and Internal Medicine Department of Al-Azhar University Hospital at new Damietta during the period from September 2018, to April 2020. All patients were subjected to complete history, clinical assessment, abdominal ultrasonography, upper GIT endoscope and laboratory investigations. Results: There was a significant relation between H.Pylori infection and the presence of esophagogastric variceal hemorrhage and H. Pylori infection was positive in 92% of the patients in group II, and 24% patients was grade II oseophageal varices, 70% grade III oseophagogastric varices, and 6% grade IV oseophagogastric varices, There was a statistically significant correlation of increased esophageal varices (grade three) in positive H pylori in group II, while in group I detection of H.pylori showed 24% patients were positive, and 76% patients were negative. Endoscopic examination showed 40 patients without esophagogastric varices (80%), 8% patients grade I, 4% patients grade II, 6% patients grade III, 2% patients grade IV, and there was a statistically significant increase on esophageal varices (grade zero) in negative H pylori in group I. Conclusion: Helicobacter Pylori infection helped in the development of portal hypertensive gastropathy as well as its severity, and increased risk of esophagogastric variceal bleeding in patients with liver cirrhosis. So, eradication and treatment of Helicobacter Pylori in all patients with liver cirrhosis helped to decrease risk of esophagogastric variceal bleeding in these patients.

This article examines the moderate role of motivation on the relationship between the big five model of personality traits and organizational commitment as an attempt to understand the influence of multitude psychological and motivational factors on employees’ behavior towards their organizational commitment. In general, the idea of this framework is taken from personality aspect and Theory of Commitment of (Allen & Meyer, 1996) which focus on how well the job is being performed by employees rather than only asking if they are doing their job. The basic foundation for forming and developing this new framework is: (1991) Allen & Meyer’s model of Organizational Commitment, Job Characteristics model of employee motivation for Hackman & Oldham (1975), and Big Five Model of Personality for Cost & McCrae. In this study, data has been collected from surveying 241 employees of one of the private universities in Turkish Republic of Northern Cyprus (TRNC), results indicate that personality has a significant negative relationship with organizational commitment (r= -.729). The importance of this framework is epitomized in deeply understanding the work and personnel psychology aspects according to the interrelated effects of personality and extrinsic motivation on employees’ behavior that will help organizations to seek and tailor best solutions to their problems and to achieve organizational development, effectiveness, and employees’ well-being.

Due to the varied needs of persons who have lost a lower limb in their everyday lives, ankle-foot prosthetic technology is continually evolving. Numerous prosthetic ankles have been created in recent years to restore the ankle function of lower limb amputees. Most ankle foot prostheses, on the other hand, are passive, such as the solid ankle cushion heel and the energy storage and release foot (ESAR). The solid ankle foot can only provide steady vertical support during ambulation; however, the ESAR foot can store energy and gradually release it throughout human walking periods, hence increasing the walking pace of amputees. The aim of this work is to describe the design and manufacture of an actuated ankle-foot prosthesis. The main benefit of powered ankles is that they are capable of mimicking natural stride, particularly in steep or uneven terrain conditions. The primary objective is to establish two degrees of freedom of ankle rotation in two planes, plantar flexion and dorsiflexion in the sagittal plane, besides inversion and eversion in the frontal plane. As software can improve the gait stability, an automatic modifiable transmission arrangement was prepared for delivering the current design motions in the sagittal plane based on empirical collected biomechanical data related to passive prosthetic normal gait circumstances. However, the ankle rolling in the frontal plane was guided mechanically by means of mono leaf spring. The majority of the ankle mechanical components are made of 7075-T6 aluminum alloy and are integrated onto ESAR carbon fiber laminated foot. For a unilateral above-knee amputee, the ankle function at self-selected walking was assessed, achieving maximum results of 10° inversion, 10° eversion, 12° plantar flexion and 18° dorsiflexion ankle angles. Also, the patient gait experiment in a normal cadence showed an improvement in plantar flexion behavior for the powered ankle in contrast with the passive ankle, У зв'язку з різними потребами людей, які втратили нижню кінцівку у повсякденному житті, технологія протезування гомілковостопного суглоба постійно розвивається. В останні роки була створена велика кількість протезів гомілковостопного суглоба для відновлення функції гомілкостопа у людей з ампутованими нижніми кінцівками. З іншого боку, більшість протезів гомілковостопного суглоба є пасивними, наприклад стопа з твердим гомілковостопним суглобом і пружною п'ятою та стопа з накопиченням і вивільненням енергії (ESAR). Твердий гомілковостоп дозволяє забезпечити лише стійку вертикальну опору під час пересування, тоді як стопа ESAR може накопичувати енергію і поступово вивільняти її під час ходьби, тим самим збільшуючи темп ходьби людей з ампутованими кінцівками. Метою даної роботи є опис конструкції та виготовлення тягового протезу гомілковостопного суглоба. Головна перевага тягових гомілковостопних суглобів полягає в тому, що вони здатні імітувати природний крок, особливо в умовах крутої чи нерівної місцевості. Основна мета полягає в тому, щоб встановити два ступені свободи обертання гомілковостопного суглоба в двох площинах, підошовне згинання і тильне згинання в сагітальній площині, а також інверсія та еверсія у фронтальній площині. Оскільки стійкість ходи може бути покращена за допомогою програмного забезпечення, було підготовлено автоматичний модифікований пристрій передачі для виконання поточних розрахункових рухів в сагітальній площині на основі зібраних емпіричних біомеханічних даних, пов'язаних з умовами ходьби на пасивному протезі. Однак обертання гомілковостопного суглоба у фронтальній площині здійснювалося механічно за допомогою монолистової ресори. Більшість механічних компонентів гомілковостопного суглоба виготовлені з алюмінієвого сплаву 7075-T6 та вбудовані в стопу ESAR з шаруватого вуглепластику. Проведено оцінку функції гомілковостопного суглоба людини з односторонньою ампутацією вище коліна при самостійній ходьбі з досягненням максимальних результатів 10° інверсії, 10° еверсії, 12° підошовного згинання і 18° тильного згинання гомілковостопного суглоба. Крім того, випробування ходи пацієнта в нормальному темпі показало поліпшення підошовного згинання тягового гомілковостопного суглоба на відміну від пасивного

Background: Self-medication with antibiotics (AB) is an ongoing main global health problem. It is defined as the use of nonprescribed medications by people on their own initiative or on the advice of another individual, without physician consultation. Lack of knowledge among parents regarding the prudent use of AB in managing common childhood illnesses can result in its misuse. On the other hand, physicians commonly prescribe AB as their first response for several symptoms, usually relating such over-prescription to patients’/parents’ pressure. Although AB are targeted to kill or inhibit the growth of bacteria and have no effect on viral agents, it is often inappropriately used to treat viral infections, such as most upper respiratory tract infections (URTI). Problems associated with the overuse of AB include development of antibacterial resistance, increasing the burden of chronic diseases, rising costs of health services. Objectives: To evaluate mothers’ Knowledge, Attitudes, and Practices (KAP) related to antibiotic use for children with URTI in a sample of mothers in Babylon Governorate and assess the associated factors with antibiotic misuse among mothers who attended primary healthcare centers and hospitals. Materials and Methods: A cross-sectional study was carried out in Babylon Governorate during the period from April 10 to June 20, 2021. Two primary healthcare centers (one in the periphery of Babylon Governorate and the other in center of Babylon Governorate) and two hospitals (one in the periphery of Babylon Governorate and the other in center of Babylon Governorate) were selected conveniently and 270 mothers who attended these centers interviewed 3–4 days per week during the period of the study. Data were gathered through structured questionnaire that was used to identify different variables in the study during the interview. Statistical analysis was carried out using Statistical Package for the Social Sciences. Results: The mean age of mothers was (30 ± 7) years old. Small percentage had adequate knowledge about antibiotic use (26.3%), and only 8.52% had positive attitudes. Also, only 10.37% had good practice. Self-medication of AB was in a large proportion of mothers (67%) and most of them depend on pharmacists as a source of information (61.24%). There was a significant association between inadequate knowledge and mothers who were housewives, school-educated, and had self-medication practice. There was a significant association between negative attitude and poor practice with mothers who had self-medication. This study revealed that mothers who lived in rural areas, school-educated, housewives, and had enough monthly income tend to self-medicate their children with AB. Conclusions: Inadequate knowledge related to mothers with school education and housewives. Self-medication with AB is related to poor KAP. Self-medication occurs mostly among mothers who are housewives, residents in rural area, had school education, and have enough income.

Trombe walls are one of the sustainable technologies because of their importance and effective rol in interior spaces by making use of solar energy to control the temperature of the interior spaces and thus achieve thermal comfort without the need to use cooling devices to reduce the energy used, the Trombe wall is an important element in solar design Passive. To save heat in indoor spaces, the main advantage of trombe walls is that they can be constructed virtually from locally available materials. These walls also reduce the need for heating and cooling the building. It is even considered a vital technology for sustainable architecture that effectively contributes to hot-arid environments like Iraq. The research will discuss the most important types of Trombe Walls, the characteristics of Trombe Walls, including the Trombe Wall formations, and the Trombe Wall technology, and the feasibility of realizing the concept of energy efficiency in Iraq using the trombe wall

This research is entitled “The Reflection Of Salik Maqaamat In The Content Of Maly Jaziri’s Poems”. It is an attempt to exhibit an aspect associated with Sufism. This respect is depicted in Salik’s Maqaamat. In the world of Sufism, the practitioner, who seeks to find the truth, must attain some stages which are called Maqaamat. The maqaamat should be reflected in the personality of the practitioner. This research lays emphasis on the nature and property of Salik within the framework of Sufism in general and Islamic Mysticism. Having presented Jaziri as a Salik, the research analyzes the poems which possess the properties of being a Salik. The quantity and quality of the reflection of maqaamat in Jaziri’s poems are presented. After highlighting the conclusions of the research, references, Arabic and English abstracts are presented. Key words: Sufism, Maqaam, Salik, God’s path, Sufism expression, Real love.

Background Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival rates of 5%, a figure which has not improved over the last few decades. Currently, there is a modest 14-month overall median survival in patients undergoing maximum safe resection plus adjuvant chemoradiotherapy. HOX gene dysregulation is now a widely recognised feature of many malignancies. Methods In this study we have focused on HOX gene dysregulation in GBM as a potential therapeutic target in a disease with high unmet need. Results We show significant dysregulation of these developmentally crucial genes and specifically that HOX genes A9, A10, C4 and D9 are strong candidates for biomarkers and treatment targets for GBM and GBM cancer stem cells. We evaluated a next generation therapeutic peptide, HTL-001, capable of targeting HOX gene over-expression in GBM by disrupting the interaction between HOX proteins and their co-factor, PBX. HTL-001 induced both caspase-dependent and –independent apoptosis in GBM cell lines. Conclusion In vivo biodistribution studies confirmed that the peptide was able to cross the blood brain barrier. Systemic delivery of HTL-001 resulted in improved control of subcutaneous murine and human xenograft tumours and improved survival in a murine orthotopic model.

The study aims to find the relationship between COVID-19 virus infections and early births in womeninfected with this virus in of Al-Fallujah city. The prospective study was conducted in Al-Fallujah cityduring the period between February 1, 2020, and September 1, 2020, at Al-Fallujah Teaching Hospital.Through the study, 100 pregnant women were received, complaining of Covid-19 infections, which werediagnosed in Al-Fallujah, and now Real Time PCR was confirmed through nasopharyngeal swabs that weretaken from Al-Fallujah Teaching Hospital. The study also included measuring the level of blood pressure,sugar andC-RP in those women during the fifth to eight week, where we were infected, and then in the 12thweek of pregnancy took place, where communication was made, and a level was measured, and as a result,these women whocompleted the period with a pre-term labor, miscarriagebefore the 24th week of pregnancyor those completed the period with successful pregnancy. In this study, 33% of COVID-19 pregnant womenwere within the age group 24-30 years followed by 30% in the age group 31-38 year. In this study, 10 % ofCOVID-19 pregnant women suffer from hypertension, 13% were with Diabetes, 35% with UTI while 70%were suffered from fever.When reaching 24th week of pregnancy, and as shown in Table 3. The study showedthat 40% COVID-19 pregnant women experienced completed the period with a pre-term labor, 10% waswith miscarriagebefore the 24thweek of pregnancy, while 50% of them completed the period continued thepregnancy. In this study, 82.5 % of COVID-19 pregnant women with preterm labor were suffered previouslyfrom fever comparing with 55% of COVID-19 pregnant women without preterm labor. The study showed thehighest mean of C-reactive protein was present COVID-19 pregnant women with preterm labor (22.5±2.14mg/ml), fan lowest mean was in women who without preterm labor (14.6±2.11 mg/ml) (P

The paper analyzes the Kurdistan Regional Government’s (KRG) natural resource strategies, such as how it deals with huge reserves of many trillion cubic feet of its natural gas as significant energy. Because natural gas belongs to the cleanest burning fossil fuels, with 30 percent less carbon than oil, it plays a role in the global fuel economy. As KRG transports its natural gas to international markets, like European countries, via Turkey it means they also participate in energy security as a new actor. Because the KRG is landlocked, strong factors may affect Kurdish natural gas strategies because KRG is surrounded by today’s partners and yesterday’s enemies politically and economically. Turkey, the neighbor of KRG, also buys its gas and has an influence on these strategies after the Ukraine crisis that pushed European countries to make a turn towards Caspian natural gas. Kurdistan is part of the best option for European energy security as it plans to diversify natural gas imports. While the KRG benefits from selling its natural gas directly to international markets, this will come with some struggles. Many of these obstacles can be classified into two types: internal and external obstacles, such as a conflict with the central government regarding how to share gas revenues. Others problems include Iranian neighbor interest on natural resources in Kurdistan and Russia that looks to Kurdish gas as its ally if Kurdistan joins the southern gas corridor pipeline.

The purpose of this study is to assess the SNP (rs2279115; - 938 C>A) polymorphism in the BCL-2 gene of Iraqi leukemic patients. The B-cell lymphoma 2 (BCL-2) gene is considered to be related with leukemia improvement. The single nucleotide polymorphism “(SNP; -938 C>A)” of BCL-2 was discovered a few years ago. In accordance with the SNP’s (rs2279115) function against leukemia, we evaluated the distribution frequency of the allele in addition to the relationship of the genotype with clinicopathological features. This study involved a case-control design in which the BCL-2 gene promoter polymorphism with the rs2279115 variant was genotyped in a total of 230 individuals, including 120 leukemia patients and 110 healthy subjects, to predict the variation in leukemic Iraqi patients. The patient group was enrolled from the Medical Euphrates Center for Oncology in the Najaf province that is involved in the WHO strategy of leukemia. From whole categories of blood, the DNA was extracted and genotyped using the BccI enzyme and the RFLP- PCR technique. The occurrences of the CC, AC, and AA alleles of the promoter BCL-2 gene polymorphism (C-938A) in leukemia patients were 38 (32%), 55 (46%), and 27 (22.5%), respectively, while control they were 46 (42%), 54 (49.1%), and 10 (9.1%), respectively in the control group (PA) was associated with a predisposition to leukemia in the Iraqi population.

YFeO3/g-C3N4 composites with varying weight ratios were prepared following three different methods The optimum weight ratio and the method of preparation for enhanced visible photocatalytic activity towards the degradation of organic contaminants were identified. The successful formation of the composites was proven by XRD and IR measurements. XPS analysis shows that the inactive Y2O3 passive layer on the hexagonal YFeO3 (h-YFeO3) disappeared during the composite formation, resulting in a direct and intimate contact of h-YFeO3/g-C3N4 which is crucial for the photocatalytic activities. The loading of h-YFeO3 varied from 1 to 20% and the highest activity was achieved at 2.4%. At the optimum loading 80% degradation of methyl orange (MO) was obtained under 5 h visible light illumination. The composite photocatalyst shows also modest activity for the photodegrading of 4-chlorophenol (4-CP). Additionally the synthesized composites were characterized by high resolution transmission electron microscopy (HR-TEM), Fourier transform infrared spectroscopy (FT-IR) and diffuse reflection UV–vis spectroscopy (DR-UV–vis). In order to determine the relative band positions of the composite photocatalysts their flat band potentials were estimated from Mott-Schottky analysis. Improved charge separation in the composite is mainly responsible for the enhanced photoactivity and supported by photoluminescence experiments.

Globally more than 100 million SNPs in populations. These variations approximately 4–5 million SNPs in a people genome, occur almost every 1000 nucleotides on average and present either unique or in many in individuals. They can act as genetic signs, associated with illness and respond to chemicals and drugs. SNPs occurrence within or near a gene play important role in disease throughout affecting gene task. Frequently many protocols have been used to study single nucleotide polymorphism (SNP) among human variants genome. Restriction fragment length polymorphism (RFLP), Amplification refractory mutation system PCR(ARMS-PCR), sequencing and SNaPshot assays considered familial methods. The potential risk of contamination after PCR is common due to further other steps. In this direction, a high resolution melting (HRM) real-time PCR method is an alternative, reducing the post-PCR transferring steps. uVariants is clarified as appropriate website for designing primers used for SNP recognition by easy and inexpensive protocol called HRM. The researchers can focus on the interest of reference SNP ID number, or “rs” ID to avoid loss time. In this article description how to uses uVariants website for primer design used in HRM technique. Aims To describe uVariants and uDesign software, application and usefulness of HRM technique primer design in the genotyping SNPs among people and public health. Accessibility and requirements uVariants and uDesign are freely accessible at: https://www.dna.utah.edu/variants/;https://www.dna.utah.edu/udesign/app.php respectively. The network server supports the browsers: Chrome, Firefox, Torch, CoolNovo, 360 Browser, Internet Explorer, Opera, and Safari., Highlights • Primer design for SNPs detection by HRM technique was build. • HRM is a new protocol, provides resource guide for scientists to design primer to detect single nucleotide polymorphism. • HRM starts post PCR amplification of interested region in the presence intercalating dye. • HRM analysis differs from standard melt curve HRM technique uses brighter dyes like SYBR at high concentrations, instrument HRM need device that gather fluorescence data at even in low temperature, and finally a program that requires more sophisticated software which uses new fluorescent scaling algorithms and curves.

To determine the effect of short education session on drug compliance on hypertensive patients visiting primary healthcare centres.The interventional study was conducted from January to May, 2017, at 10 primary healthcare centres that were selected through multi-stage random sampling from those functioning under the Baghdad/Al-Rusafa Health Directorate, Baghdad, Iraq. Those included were patients aged 20-79 years diagnosed with hypertension with a history of at least one year. The subjects were divided into two intervention, and control groups. After baseline interviews regarding compliance with medical treatment. In each visit, 3-4 patients were selected, and were exposed to the education session about the risks of untreated hypertension, and they were given an appointment for one month later to measure their compliance rate. In the control group, the compliance rate was measured twice within a month. Data was analysed using SPSS 24.Of the 600 subjects, there were 300(50%) in each of the two groups. The compliance rate increased significantly within the intervention group (p=0.0001) and also in comparison with the controls (p=0.0001). Apart from medicines per day, all other factors showed non-significant association with compliance rate.The health education session caused significant improvement in the rate of compliance with drug regimen in hypertensive patients.

Consolidated drained triaxial compression tests (CD) were conducted to determine the compression properties of remolded samples collected from hillslope in residual soil. The test results showed that the effective drained shear strength of residual soil was primarily affected by the degree of weathering according to depth, parent rock material, and clay contents and also influenced by initial moisture content. These samples were classified as silt soils of high to low plasticity. CD tests were performed on samples prepared under 100 and 200 kPa remolding pressure with three different confining pressures of about 50, 100 and 150 kPa. Predicted results showed that the soil strength increased with increasing samples’ density for those who prepared with a higher remolding pressure. According to the soil composition, a clear decrease in soil cohesion was observed for samples collected at a deeper depth, while a further increase in the effective internal friction angle was observed for samples collected with a lower depth. However, this explains the significant influence of clay contents that can be represented as a relevant relation. Therefore, the results indicated that the studied residual soils have physical and geotechnical properties that are highly dependent on the clay and initial water contents. Then, the concept of long-term stability analysis of hillslope of Balai Cerap area (in UTM/ Malaysia) was presented in the form of factors of safety as discussed later in this study by employing Geo-Studio program (SLOPE/W application) with Limit Equilibrium Method.

Globally more than 100 million SNPs in populations. These variations approximately 4–5 million SNPs in a people genome, occur almost every 1000 nucleotides on average and present either unique or in many in individuals. They can act as genetic signs, associated with illness and respond to chemicals and drugs. SNPs occurrence within or near a gene play important role in disease throughout affecting gene task. Frequently many protocols have been used to study single nucleotide polymorphism (SNP) among human variants genome. Restriction fragment length polymorphism (RFLP), Amplification refractory mutation system PCR(ARMS-PCR), sequencing and SNaPshot assays considered familial methods. The potential risk of contamination after PCR is common due to further other steps. In this direction, a high resolution melting (HRM) real-time PCR method is an alternative, reducing the post-PCR transferring steps. uVariants is clarified as appropriate website for designing primers used for SNP recognition by easy and inexpensive protocol called HRM. The researchers can focus on the interest of reference SNP ID number, or “rs” ID to avoid loss time. In this article description how to uses uVariants website for primer design used in HRM technique. Aims: To describe uVariants and uDesign software, application and usefulness of HRM technique primer design in the genotyping SNPs among people and public health. Accessibility and requirements: uVariants and uDesign are freely accessible at: https://www.dna.utah.edu/variants/;https://www.dna.utah.edu/udesign/app.php respectively.The network server supports the browsers: Chrome, Firefox, Torch, CoolNovo, 360 Browser, Internet Explorer, Opera, and Safari. Keywords: HRM, SNP, Point mutation, Real-time PCR, Primer design, Web service, PCR

An increased rate of cellular proliferation is a hallmark of cancer and may be accompanied by an increase in ribosome biogenesis and dysregulation in rRNA synthesis. In this regard, CX-5461 has been developed as a novel RNA polymerase I inhibitor and is currently in Phase I/II clinical trials for solid and hematological malignancies. In the present study, interactions between CX-5461 and single-dose X-ray exposure were assessed using isobologram analysis using MTS assay and drug-induced cell death was assessed using flow cytometric, confocal microscopy and Western blot analysis. Combination treatments involving CX-5461 and single-dose X-ray exposure highlighted increased effectiveness compared to individual treatment alone in the CaSki cervical cancer line, with marked synergistic interaction occurring within the low-drug (50 nM) and low-dose radiation range (2&ndash, 6 Gy). Cell lines challenged with CX-5461 demonstrated the presence of DNA damage, induction of apoptosis, autophagy and senescence alongside high percentages of G2/M cell cycle arrest. In addition, we report preferential sensitivity of ovarian cancer cells with BRCA2 mutation to this novel agent. Taken together, CX-5461 displayed a broad spectrum of activity in a panel of solid cancer cell lines with IC50 values ranging from 35 nM to &gt, 1 &micro, M. The work described herein identifies the synergistic effects of CX-5461 in combination with X-rays in solid cancers and may also aid in the design of clinical trials involving this novel agent.