28 results on '"Morgan, J. G."'
Search Results
2. Three aspects of stellar evolution near the main sequence
- Author
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Morgan, J. G.
- Subjects
520 - Published
- 1979
3. Sociology in America : a study of its institutional development until 1900
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Morgan, J. G.
- Subjects
300.1 ,Sociology ,History ,United States - Abstract
This thesis attempts to provide a comprehensive review of the teaching of sociology in universities and colleges in the United states in tne nineteenth century. (The primary sources are the catalogues and various other publications, such as presidential reports and alumni yearbooks, of 663 institutions from their foundings until the end of the academic year 1900-01). Evidence of the teaching of courses in sociology, or in some closely related study such as social science or social problems, was found in 227 of the total number of institutions. After some introductory observations on the extensive inclusion of sociology in American university curricula, the first chapter goes on to describe the nature of the sources used and to comment upon previous studies of a similar type, none of which have provided the sort of complete historical documentation of the rise of sociology teaching as the present study sets out to do. This specific development is set in the general context of higher education in the nineteenth century which saw a decline of older methods based upon the recitation system in favour of a more liberal attitude to teaching and research. The Land Grant College Act of 1862, with its particular encouragement of scientific training, and the influence of German ideals in higher education are singled out as movements of great importance for the changing conception of higher education. The second chapter contains a discussion of some of the first attempts at sociological writing in the United States, mostly before the Civil War. The largely Aristotelian and conservative views of the southern writers are contrasted with those of the Utopian social thinkers of the North. Here, as throughout the thesis, emphasis is placed upon the relationship between the attempts at sociological theory and the social context in which they arose. Chapter III describes in some detail the beginnings of sociology teaching in universities and colleges from the 1860's, witn some reference to instruction in social matters before this time. For the first years after its introduction attention is paid to each institution which offered sociology; for the later years particular institutions are singled out for special comment where noteworthy new departures were made. Chapter IV describes the regional development of sociology teaching from its beginnings in Eastern institutions. Graphic illustration of its spread is provided in a chronological series of maps. The second part of the chapter relates the development of sociology to contemporary movements in theology, particularly the ideas of Social Christianity and the Social Gospel. The extreme involvement of sociologists in these movements, and the encouragement given to sociology in certain denominations which were also prominent in the Social Gospel, are used as facts to support the contention that the outlooks upon society of sociologists and Social Gospel theologians were not only parallel but often so closely interwoven as to be inseparable. Chapter V goes into greater detail concerning the nature of the sociology being taught by describing various representative courses, with much illustrative material drawn from catalogue summaries of such courses. In the second part of the chapter some of the most popular textbooks for sociology courses are described. Chapter VI is concerned with those who taught sociology; four cases of opposition on the part of university authorities to certain aspects of the teaching of sociology are discussed. The education of sociology teachers is outlined with special reference to the influence which German higher education exercised over many of the most prominent American sociologists. Chapter VII documents the rise of sociology as a subject for graduate study in American universities and colleges, and includes lists of doctorates submitted in sociology and in sociological topics up to 1900. The subsequent careers of graduate students in sociology are briefly summarized. In the concluding chapter emphasis is placed upon the essentially American nature of sociology in the United States, its peculiar importance lying in its early and generally enthusiastic inclusion in the curricula of institutions of higher learning. Some contrasts are made in this respect with its position in Europe in the same period. Its popularity as a university subject is contrasted with the ill-developed nature of sociological theory in America at the time; some attempt is made to characterize such theory. A series of appendices is included to provide full documentation of the colleges and universities under review, a complete catalogue of courses in sociology, a bibliography of textbooks recommended in course descriptions together with writers cited without reference to particular works in such descriptions, chronological lists of the founding of departments of sociology and social science, a list of appointments in sociology and social science, and a catalogue of teachers of courses in sociology, outlining the institutions at which they taught, up to 1901.
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- 1966
4. Colonic Dendritic Cells, Intestinal Inflammation, and T Cell-Mediated Bone Destruction Are Modulated by Recombinant Osteoprotegerin
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Ashcroft, J A., Cruickshank, M S., Croucher, I P., Perry, J M., Rollinson, S, Lippitt, M J., Child, A J., Dunstan, C, Felsburg, J P., Morgan, J G., and Carding, R S.
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- 2003
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5. Assessment Of Condenser-Humidifiers With Special Reference To A Multiple-Gauze Model
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Mapleson, W. W., Morgan, J. G., and Hillard, E. K.
- Published
- 1963
6. Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity
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Hirata, M, primary, Shimomura, Y, additional, Yoshida, M, additional, Morgan, J G, additional, Palings, I, additional, Wilson, D, additional, Yen, M H, additional, Wright, S C, additional, and Larrick, J W, additional
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- 1994
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7. Myocardial Alterations in Senescent Mice and Effect of Exercise Training: A Strain Rate Imaging Study
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Derumeaux, G., Ichinose, Fumito, Raher, M. J., Morgan, J. G., Coman, T., Lee, C., Cuesta, J. M., Thibault, H., Bloch, K. D., Picard, Michael Howard, and Scherrer-Crosbie, Marielle
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aging ,echocardiography ,exercise - Abstract
Background: Aging is accompanied by an alteration in myocardial contractility. However, its noninvasive detection is difficult. The effect of chronic exercise on this decrease is unknown. Murine models of senescence are increasingly used to test therapies in aging. We tested whether strain rate imaging detected left ventricular (LV) systolic dysfunction in aging mice and was able to assess a potential improvement after exercise. Methods and Results: Young (3 weeks), adult (2 to 3 months), and old (6 to 18 months) C57BL6 male mice underwent echocardiograms with strain rate imaging, either in sedentary conditions or before, 2 weeks and 4 weeks after chronic swimming. Hemodynamic parameters of LV function including maximal and end-systolic elastance were obtained before euthanizing. LV fibrosis was measured using Sirius red staining. Conventional echocardiography was unable to detect LV systolic dysfunction in old mice, whereas both systolic strain rate and load-independent hemodynamic parameters such as preload recruitable stroke work and end-systolic elastance were significantly decreased. Both strain rate and load-independent hemodynamic parameters normalized after 4 weeks of exercise. Both endocardial and epicardial fibrosis were increased in the LV of aging mice. Endocardial fibrosis decreased in exercised aged mice. Conclusions: Strain rate noninvasively detects LV systolic dysfunction associated with aging in mice, whereas conventional echocardiography does not. Chronic exercise normalizes LV systolic function and decreases fibrosis in old mice. Strain rate imaging in mice may be a useful tool to monitor the effect of new therapeutic strategies preventing the myocardial dysfunction associated with aging.
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- 2008
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8. Sp1, a CAAT-binding factor, and the adenovirus major late promoter transcription factor interact with functional regions of the gamma-fibrinogen promoter
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Morgan, J G, Courtois, G, Fourel, G, Chodosh, L A, Campbell, L, Evans, E, and Crabtree, G R
- Abstract
To study the factors which influence the coordinately and developmentally regulated expression of the three adjacent fibrinogen genes, we have defined the functional regions of the gamma-fibrinogen promoter and the proteins which bind to them. Using a series of 5' and internal deletion mutations, we found that sequences between 88 and 43 base pairs (bp) upstream of the gamma-fibrinogen transcription initiation site functioned in cis to direct properly initiated mRNA accumulation in transfected hepatocytes. The efficient function of these sequences was highly distance dependent, since transcriptional activity decreased by 92% when they were moved 32 bp upstream of the TATA box. We demonstrated that two known and one putative transcriptional factors interacted with this 47-bp sequence. The transcription factor Sp1 interacted with sequences between -51 and -46 as demonstrated by protection from DNase I digestion with the purified protein. Directly adjacent to the Sp1 site, between nucleotides -66 and -53, there was a sequence which bound a CAAT-binding factor. Finally, sequences just 5' to the CAAT factor-binding site interacted with the adenovirus major late transcriptional factor as previously demonstrated. Internal deletion mutations which disrupt these interactions diminished the activity of the promoter in vivo. One consequence of the interaction of these proteins is that a bend is placed in the DNA at or near their sites of interaction.
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- 1988
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9. A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.
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Durand, D B, Bush, M R, Morgan, J G, Weiss, A, and Crabtree, G R
- Abstract
Using a transient transfection assay, we have defined the sequences required for the activation of the IL-2 gene in response to signals from the T cell antigen receptor. To do so we have transfected the human T cell line Jurkat with hybrid DNA constructs in which fragments from the IL-2 gene are linked to an indicator gene. The indicator gene product, as well as IL-2 production from the endogenous IL-2 gene were assayed after activation of the transfected Jurkat cells by various stimuli. We have demonstrated that a 275 bp fragment stretching from 52 to 326 bp upstream of the IL-2 gene transcription initiation site is required for expression of the linked indicator gene. This IL-2 gene fragment has several of the characteristics of a transcriptional enhancer element, in that it functions in both orientations and will enhance the expression from the promoter of an unrelated gene. Such enhancement occurred only after activation of Jurkat cells through the T cell antigen receptor. More specifically, this 275 bp fragment activated the expression of a linked gene after binding of a monoclonal antibody to the Jurkat T cell antigen receptor in the presence of PMA. In addition, calcium ionophore, which circumvents antigen receptor binding in T cell activation, induced the expression of the linked gene through this 275 bp sequence, in the presence of PMA. Finally, in a mutant Jurkat cell line lacking T3/antigen receptor complexes at the cell surface, no expression due to the IL-2 5' flanking region was seen after exposure to antibody to the T cell antigen receptor plus PMA or to PHA plus PMA. In contrast, calcium ionophore plus PMA did induce the expression of a linked gene through the IL-2 5' flanking region in the mutant Jurkat cell line. The responsiveness of the transfected hybrid genes containing the IL-2 regulatory region paralleled the expression of the endogenous IL-2 gene, as determined by IL-2 bioassays. We conclude that the 275 bp IL-2 sequence (-326 to -52 bp) is a target for the signal pathway originating at the T cell antigen receptor. Definition of this 275 bp target sequence should now permit the isolation of the molecules that bind to and activate the IL-2 gene.
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- 1987
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10. A reappraisal of the gap in the HR diagram of M67
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Morgan, J. G., primary and Eggleton, P. P., additional
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- 1978
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11. The evolutionary status of RS CVn binaries
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Morgan, J. G., primary and Eggleton, P. P., additional
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- 1979
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12. Survey of three megalithic sites in Argyllshire
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BAILEY, M. E., primary, COOKE, J. A., additional, FEW, R. W., additional, MORGAN, J. G., additional, and RUGGLES, C. L. N., additional
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- 1975
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13. RELIGION IN SOCIAL CONTEXT: TRADITION AND TRANSITION. By N. J. Demerath III, and Phillip E. Hammond. New York: Random House, 1969. 246 pp. $5.95
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Morgan, J. G., primary
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- 1970
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14. RESPIRATORY HUMIDIFIERS
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Mapleson, W. W., primary, Morgan, J. G., additional, and Hillard, E. K., additional
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- 1963
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15. High-resolution detection of loss of heterozygosity of dinucleotide microsatellite markers.
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Hourihan RN, O'Sullivan GC, and Morgan JG
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- Humans, Neoplasms genetics, Dinucleotide Repeats, Loss of Heterozygosity, Microsatellite Repeats
- Abstract
Dinucleotide microsatellite markers are frequently investigated to study inheritance, genetic stability, and allele frequency distribution in a wide variety of genetic disorders. Previous studies have encountered significant problems regarding resolution and detection of dinucleotide, microsatellites. In this study, a useful method to investigate loss of heterozygosity (LOH) of dinucleotide microsatellite markers is described that involves the use of nondenaturing (Spreadex) submerged gel electrophoresis and SYBR Green I nucleic acid staining. This method omits the gel casting step and the use of hazardous radioactive materials frequently used in many microsatellite studies that employ polyacrylamide gel nucleic acid denaturation analysis. Using this method, 62 patients' paired tumor and normal samples were investigated to detect allele deletions in a region of chromosome 7q31.1, which is believed to harbor a tumor suppressor gene. Interpretable results were obtained in all cases. These results were compared to those attained using ABI Prism Genetic Analyzer 310 and Gene-Scan. There were no discrepancies in results obtained between the two assays. The Spreadex system is cheap, does not require larger equipment costs, and may prove to be a useful system for high-throughput investigation of microsatellites. It may have diagnostic significance and also prove useful if applied to population-based genomic screening and linkage analysis.
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- 2001
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16. Rotavirus gastroenteritis among paediatric patients at Tralee general hospital.
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O'Mahony J, Christie G, Morgan JG, and Hill C
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- Age Distribution, Child, Child, Preschool, Female, Gastroenteritis economics, Hospital Costs statistics & numerical data, Hospitals, General, Humans, Incidence, Infant, Infection Control, Ireland epidemiology, Length of Stay statistics & numerical data, Male, Reverse Transcriptase Polymerase Chain Reaction, Rotavirus Infections economics, Seasons, Gastroenteritis epidemiology, Gastroenteritis virology, Rotavirus Infections epidemiology, Rotavirus Infections virology
- Abstract
Rotavirus infection among paediatric patients in Tralee general hospital was monitored over 4 years (1994 - 1998). A total of 2,319 specimens from gastroenteritis patients less than 7 years old were tested by latex agglutination assay, of which 203 (8.75%) were deemed positive. An inverse correlation was observed between age and susceptibility to infection, with the very young (under 2 years) most frequently infected. The virus was almost equally distributed among males (53%) and females (47%) testing positive for rotavirus. A distinctive early Spring peak of infection was evident annually, although the largest peak was identified in December 1997. This correlated with a significant change in circulating genotype as determined by RT-PCR based genotyping analysis of 45 rotavirus samples. In 1997, rotavirus accounted for 64% of all identified paediatric enteric agents at Tralee General for which an infectious agent could be identified. The average hospital stay was 3.2 days, and the direct hospital costs for rotavirus associated gastroenteritis was estimated at pounds sterling 31,232 per annum.
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- 2000
17. VP4 and VP7 genotyping of rotavirus samples recovered from infected children in Ireland over a 3-year period.
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O'Mahony J, Foley B, Morgan S, Morgan JG, and Hill C
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- Antigens, Viral genetics, Child, DNA Primers, Feces virology, Genotype, Humans, Ireland, RNA, Viral analysis, RNA, Viral genetics, Reverse Transcriptase Polymerase Chain Reaction methods, Rotavirus classification, Rotavirus isolation & purification, Time Factors, Capsid genetics, Capsid Proteins, Rotavirus genetics, Rotavirus Infections virology
- Abstract
Between September 1995 and August 1998, the incidence and diversity of the main human rotavirus genotypes (G1, G2, G3, and G4 and P[8], P[4], P[6], and P[9]) among Irish children were determined by using established and adapted reverse transcriptase PCR-based genotyping methods. From a total of 193 rotavirus-positive specimens collected from nine hospitals we successfully identified the P type in 182 (94%) of the samples and the G type in 165 (85.5%) of the samples. Only four samples could not be assigned a G or P type. Two P types existed in Ireland, P[8] (78%) and P[4] (16%), and their relative incidence varied over the 3 years of this study. No P[6] or P[9] types were detected. G1 was the most predominant G type (55%), and the incidences of G2, G3, and G4 isolates were 15.5, 1, and 11%, respectively. Three percent of the samples tested had a mixed G type. A P and G type was assigned to 158 (81.8%) of samples. Of the typeable samples, G1 P[8] was the most prevalent (65%), whereas G2 P[4] (17%), G3 P[8] (1%), G4 P[8] (12%), and mixed types (all G1/ G4 P[8]) (4%) were detected less frequently. In the third year a significant genotypic shift from G1 P[8] to G2 P[4] and G4 P[8] was observed. During the study, we noticed that the inclusion of random primers during cDNA synthesis greatly increased the specificity of the PCR typing assays. No correlation was seen between the contributing hospitals and a specific genotype. In conclusion, the coverage of infection given by the recently licensed tetravalent vaccine would be significantly high in Ireland, although future monitoring of genotypic changes among Irish isolates should be encouraged.
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- 1999
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18. Early undifferentiated connective tissue disease. IV.Musculoskeletal manifestations in a large cohort of patients with undifferentiated connective tissue diseases compared with cohorts of patients with well-established connective tissue diseases: followup analyses in patients with unexplained polyarthritis and patients with rheumatoid arthritis at baseline.
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Alarcón GS, Willkens RF, Ward JR, Clegg DO, Morgan JG, Ma KN, Singer JZ, Steen VD, Paulus HE, Luggen ME, Polisson RP, Ziminski CM, Yarboro C, and Williams HJ
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- Adult, Aged, Arthritis diagnosis, Arthritis, Rheumatoid diagnosis, Cohort Studies, Connective Tissue Diseases therapy, Female, Follow-Up Studies, Humans, Joint Diseases diagnosis, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Musculoskeletal Diseases diagnosis, Predictive Value of Tests, Recurrence, Time Factors, Treatment Outcome, Connective Tissue Diseases diagnosis
- Abstract
Objectives: To examine the musculoskeletal manifestations in a large cohort of patients (n = 410) diagnosed with either a well-established connective tissue disease (CTD) (n = 197) or an early undifferentiated CTD (n = 213) with a symptom duration of <1 year. This study was aimed at determining the predictive value of demographic, clinical, and laboratory features on outcome in patients with unexplained polyarthritis (UPA) (from the early undifferentiated CTD cohort; n = 67) or rheumatoid arthritis (RA) (from the well-established CTD cohort; n = 57), over a 5-year followup period., Methods: Patients from both cohorts were assessed at years 1, 3, and 5. At the study visits, clinical data were collected in a standardized manner, and sera were obtained and stored. A priori criteria were established for patient ascertainment and diagnosis over the duration of the study. Standard statistics were used for comparisons of baseline characteristics in patients diagnosed as having systemic lupus erythematosus, RA, undifferentiated CTD, and UPA at entry into the cohorts. Baseline features in patients with UPA were examined according to the different subsequent outcomes (RA, CTD, or undifferentiated CTD, remission [nonpersistent], or persistent or active UPA). Baseline features in patients with RA whose disease remained active versus those in whom remission was attained were also examined. Two multivariable analyses, classification trees and polychotomous logistic regression, were performed to predict disease outcomes over time., Results: The overall rate of ascertainment for the 410 patients ranged from 90 % at year 1 to 71 % at year 5. Patients with established CTDs showed a tendency for more stable diagnoses than those with early undifferentiated CTDs (90-100% versus 45-70%). Consistent baseline predictors of persistent active disease among patients with RA, in both univariate and multivariable analyses, were higher joint counts for pain and tenderness and higher erythrocyte sedimentation rate (ESR). In approximately 20% of patients who were classified as having RA when they originally entered the cohort, the disease was in remission at 5 years. Twenty percent of the patients originally classified as having UPA developed RA over the duration of the study. These patients tended to be older and to have swelling of small joints at baseline. However, a consistent pattern of predictive variables could not be identified in the multivariable analyses, other than at year 1 (higher small joint counts for swelling and higher ESR)., Conclusion: Baseline features (joint counts, and ESR) among RA patients were variously predictive of persistently active disease at years 1-5. Consistent baseline predictors of outcome among patients with UPA only emerged at year 1. Remission occurred in approximately 20% of RA patients, whereas a similar percentage of patients with UPA developed RA. These findings have implications with regard to treatment decisions in patients with early RA and/or UPA.
- Published
- 1996
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19. The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes.
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Morgan JG, Dolganov GM, Robbins SE, Hinton LM, and Lovett M
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- Amino Acid Sequence, Animals, Base Sequence, Biotin, Blotting, Southern, Cells, Cultured, Cloning, Molecular, Databases, Factual, Humans, Lymphocyte Activation, Lymphocytes immunology, Mice, Molecular Sequence Data, Oligodeoxyribonucleotides, Polymerase Chain Reaction methods, Protein Biosynthesis, Saccharomyces cerevisiae, Sequence Homology, Amino Acid, DNA genetics, DNA isolation & purification, Genes, Regulator, Interleukin-4 genetics, Interleukin-6 genetics, Transcription, Genetic
- Abstract
We have developed modifications to direct cDNA selection that allow the rapid and reproducible isolation of low abundance cDNAs encoded by large genomic clones. Biotinylated, cloned genomic DNAs are hybridized in solution with amplifiable cDNAs. The genomic clones and attached cDNAs are captured on streptavidin coated magnetic beads, the cDNAs are eluted and amplified. We have applied this protocol to a 425kb YAC that contains the human IL4 and IL5 genes. After two cycles of enrichment twenty-four cDNAs were evaluated, all of which were homologous to the YAC. DNA sequencing revealed that nine cDNAs were 100% homologous to the interferon regulatory factor 1 (IRF1) gene. Six clones were 70% homologous to the murine P600 gene, which is coexpressed with IL4 and IL5 in mouse Th2 cells. The nine remaining clones were unique within the sequence databases and were non redundant. All of the selected cDNAs were initially present at very low abundance and were enriched by as much as 100,000-fold in two cycles of enrichment. This modified selection technique should be readily applicable to the isolation of many candidate disease loci as well as the derivation of detailed transcription maps across large genomic regions.
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- 1992
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20. Nucleotide sequence of the gamma chain gene of rat fibrinogen: conserved intronic sequences.
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Morgan JG, Holbrook NJ, and Crabtree GR
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- Amino Acid Sequence, Animals, Base Sequence, Introns, Macromolecular Substances, Rats, Fibrinogen genetics, Genes
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- 1987
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21. The adenovirus major late transcription factor activates the rat gamma-fibrinogen promoter.
- Author
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Chodosh LA, Carthew RW, Morgan JG, Crabtree GR, and Sharp PA
- Subjects
- Animals, RNA Polymerase II metabolism, Rats, Regulatory Sequences, Nucleic Acid, Transcription, Genetic, Viral Proteins genetics, Adenoviruses, Human genetics, DNA-Binding Proteins genetics, Fibrinogen genetics, Gene Expression Regulation, Promoter Regions, Genetic, Transcription Factors genetics
- Abstract
The major late transcription factor (MLTF) is a 46-kilodalton polypeptide that specifically binds to and activates transcription from the major late promoter of adenovirus. The presence of this promoter-specific transcription factor in uninfected HeLa cell extracts suggests that MLTF is also involved in the transcription of cellular genes. This report demonstrates that MLTF specifically stimulates transcription of the rat gamma-fibrinogen gene through a high-affinity binding site. Stimulation of transcription by MLTF was not dependent on the exact position of the MLTF binding site with respect either to the transcription initiation site or to adjacent promoter elements. These results suggest that one of the cellular functions of MLTF is to control gamma-fibrinogen gene expression.
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- 1987
- Full Text
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22. Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters.
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Courtois G, Morgan JG, Campbell LA, Fourel G, and Crabtree GR
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- Albumins genetics, Base Sequence, Binding, Competitive, Cell Line, Deoxyribonuclease I, Regulatory Sequences, Nucleic Acid, DNA-Binding Proteins genetics, Fibrinogen genetics, Gene Expression Regulation, Liver physiology, Nuclear Proteins physiology, Promoter Regions, Genetic, Transcription Factors genetics, alpha 1-Antitrypsin genetics
- Abstract
The orderly and sequential activation of genes during development is hypothesized to be related to the selective expression of groups of regulatory proteins acting primarily at the level of transcription. A nuclear protein was found in hepatocytes, but not other cell types, that binds to a sequence required for hepatocyte-specific transcription of the gene for the beta chain of fibrinogen. This protein, hepatocyte nuclear factor 1 (HNF1), also interacts with homologous sequences required for optimal promoter function of the genes for the alpha chain of fibrinogen and alpha 1-antitrypsin. The promoter or enhancer regions for several viral and cellular genes not expressed in the liver did not compete for this binding. The restricted expression of HNF1 and its selective interaction with the control regions of several liver-specific genes indicate that it is involved in developmentally regulated gene expression in the liver.
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- 1987
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23. Purification and characterization of two aminopeptidases from guinea-pig small-intestinal mucosa. Cavian intestinal tripeptide hydrolases.
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Morgan JG and Donlon J
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- Aminopeptidases classification, Animals, Chemical Phenomena, Chemistry, Electrophoresis methods, Guinea Pigs, Hydrolysis, Molecular Conformation, Peptide Hydrolases isolation & purification, Substrate Specificity, Aminopeptidases isolation & purification, Intestinal Mucosa enzymology, Intestine, Small enzymology
- Abstract
Two electrophoretically distinct cytosolic peptide hydrolases from guinea-pig small-intestinal mucosa have been highly purified by a six-step procedure comprising extraction from mucosal homogenate, ammonium sulphate fractionation, DEAE-cellulose chromatography, chromatofocusing, calcium phosphate chromatography and Sephadex G-100 gel filtration. They have similar apparent molecular masses as determined by gel filtration (Mr = 68 000) or by sodium dodecyl sulphate gel electrophoresis (Mr = 72 000). Both are aminopeptidases with optimum activity at pH 7.6. They are strongly inhibited by p-hydroxymercuribenzoate, o-phenanthroline and bestatin. Although both hydrolyse some dipeptides they have a distinctive kinetic preference for tripeptides composed of aromatic or non-polar residues. Their affinities for some tripeptides are particularly high and also the hydrolysis of some substrates exhibits biphasic kinetics. These two aminotripeptidases are similar but they can be differentiated from each other and from a number of other aminopeptidases.
- Published
- 1985
- Full Text
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24. Carcinoid tumors of the gastrointestinal tract.
- Author
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Morgan JG, Marks C, and Hearn D
- Subjects
- Age Factors, Appendiceal Neoplasms diagnosis, Appendiceal Neoplasms pathology, Appendiceal Neoplasms surgery, Appendix pathology, Colon pathology, Colonic Neoplasms diagnosis, Colonic Neoplasms pathology, Colonic Neoplasms surgery, Duodenal Neoplasms diagnosis, Duodenal Neoplasms pathology, Duodenal Neoplasms surgery, Duodenum pathology, Female, Humans, Intestinal Neoplasms diagnosis, Intestinal Neoplasms pathology, Intestinal Neoplasms surgery, Intestine, Small pathology, Male, Middle Aged, Rectal Neoplasms diagnosis, Rectal Neoplasms pathology, Rectal Neoplasms surgery, Rectum pathology, Sex Factors, Stomach pathology, Stomach Neoplasms diagnosis, Stomach Neoplasms pathology, Stomach Neoplasms surgery, Carcinoid Tumor diagnosis, Carcinoid Tumor pathology, Gastrointestinal Neoplasms diagnosis
- Abstract
The charts of 135 patients with gastrointestinal carcinoid tumors diagnosed over a 22-year period at 2 hospitals are reviewed and the clinical and pathological aspects discussed. Carcinoids occur most commonly in the appendix, jejunoileum, and rectum. Those smaller than 1 cm in diameter provide evidence of malignant potential only occasionally; lesions in the 1-1.9 cm range do this quite variably, and tumors 2 cm and larger are almost always invasive or metastatic or both. All gastrointestinal carcinoids except those of the appendix enlarge, invade, and metastasize predictably if given sufficient time. Most carcinoids except those of the rectum have already been adequately treated surgically when diagnosed by the pathologist. Local excision is effective treatment for noninvasive rectal carcinoids smaller than 2 cm in diameter, but those that have invaded or grown to 2 cm should undergo more radical resection. In general, gastrointestinal carcinoids carry better prognoses than do adenocarcinomata, and even in the presence of distant metastases long-term survival occurs in a significant number of patients. The frequent concomitance of associated malignant diseases accounts for as many or more deaths in these patients than the carcinoids themselves.
- Published
- 1974
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25. Some observations on the incidence of respiratory cancer in nickel workers.
- Author
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MORGAN JG
- Subjects
- Humans, Incidence, Lung Neoplasms statistics & numerical data, Nickel adverse effects, Occupational Diseases, Respiratory Tract Neoplasms
- Published
- 1958
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- View/download PDF
26. Assessment of condenser-humidifiers with special reference to a multiplegauze model.
- Author
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MAPLESON WW, MORGAN JG, and HILLARD EK
- Subjects
- Humans, Household Articles, Household Products, Humidity, Nebulizers and Vaporizers, Ventilators, Mechanical
- Published
- 1963
- Full Text
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27. Work in progress [abridged].
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Morgan JG
- Published
- 1966
28. A simplified method for the estimation of nickel in urine.
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MORGAN JG
- Subjects
- Humans, Body Fluids, Nickel urine, Regression Analysis
- Published
- 1960
- Full Text
- View/download PDF
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