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5 results on '"Murindahabi, Monique"'

1. Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Author

Uwimana, Aline, Legrand, Eric, Stokes, Barbara H., Ndikumana, Jean-Louis Mangala, Warsame, Marian, Umulisa, Noella, Ngamije, Daniel, Munyaneza, Tharcisse, Mazarati, Jean-Baptiste, Munguti, Kaendi, Campagne, Pascal, Criscuolo, Alexis, Ariey, Frédéric, Murindahabi, Monique, Ringwald, Pascal, Fidock, David A., Mbituyumuremyi, Aimable, and Menard, Didier

Published
2020
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2. Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Author

Uwimana, Aline, Legrand, Eric, Stokes, Barbara H., Ndikumana, Jean-Louis Mangala, Warsame, Marian, Umulisa, Noella, Ngamije, Daniel, Munyaneza, Tharcisse, Mazarati, Jean-Baptiste, Munguti, Kaendi, Campagne, Pascal, Criscuolo, Alexis, Ariey, Frédéric, Murindahabi, Monique, Ringwald, Pascal, Fidock, David A., Mbituyumuremyi, Aimable, and Menard, Didier

Published
2021
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3. Peripheral and Placental Prevalence of Sulfadoxine–Pyrimethamine Resistance Markers in Plasmodium falciparum among Pregnant Women in Southern Province, Rwanda

Author

Alruwaili, Muharib, primary, Uwimana, Aline, additional, Sethi, Reena, additional, Murindahabi, Monique, additional, Piercefield, Emily, additional, Umulisa, Noella, additional, Abram, Andrew, additional, Eckert, Erin, additional, Munguti, Kaendi, additional, Mbituyumuremyi, Aimable, additional, Gutman, Julie R., additional, and Sullivan, David J., additional

Published
2023
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4. Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13R561H mutant parasites in Rwanda

Author

Uwimana, Aline, Legrand, Eric, Stokes, Barbara H., Ndikumana, Jean-Louis Mangala, Warsame, Marian, Umulisa, Noella, Ngamije, Daniel, Munyaneza, Tharcisse, Mazarati, Jean-Baptiste, Munguti, Kaendi, Campagne, Pascal, Criscuolo, Alexis, Ariey, Frédéric, Murindahabi, Monique, Ringwald, Pascal, Fidock, David A., Mbituyumuremyi, Aimable, and Menard, Didier

Abstract

Artemisinin resistance (delayed P. falciparumclearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa1–4. Here we genotyped the P. falciparum K13(Pfkelch13) propeller domain, mutations in which can mediate artemisinin resistance5,6, in pretreatment samples collected from recent dihydroarteminisin-piperaquine and artemether-lumefantrine efficacy trials in Rwanda7. While cure rates were >95% in both treatment arms, the Pfkelch13R561H mutation was identified in 19 of 257 (7.4%) patients at Masaka. Phylogenetic analysis revealed the expansion of an indigenous R561H lineage. Gene editing confirmed that this mutation can drive artemisinin resistance in vitro. This study provides evidence for the de novo emergence of Pfkelch13-mediated artemisinin resistance in Rwanda, potentially compromising the continued success of antimalarial chemotherapy in Africa.

Published
2020
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5. Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13R561H mutant parasites in Rwanda

Author

Uwimana, Aline, Legrand, Eric, Stokes, Barbara H., Ndikumana, Jean-Louis Mangala, Warsame, Marian, Umulisa, Noella, Ngamije, Daniel, Munyaneza, Tharcisse, Mazarati, Jean-Baptiste, Munguti, Kaendi, Campagne, Pascal, Criscuolo, Alexis, Ariey, Frédéric, Murindahabi, Monique, Ringwald, Pascal, Fidock, David A., Mbituyumuremyi, Aimable, and Menard, Didier

Published
2021
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