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11 results on '"Negi, Reena"'

1. Oxidative Stress Induced Lipid Peroxidation And DNA Adduct Formation In The Pathogenesis Of Multiple Myeloma And Lymphoma

Author

Tandon, Ravi, Bhakar, Mahima, Pande, Deepti, Karki, Kanchan, Negi, Reena, and Khanna, H. D.

Subjects
Oxidative Stress, Malondialdehyde, 8-hydroxy-2-deoxy-Guanosine, Multiple myeloma, Lymphoma, Biochemistry, QD415-436
Abstract

Objective: To access the oxidative stress status by quantification of byproducts generated during lipid peroxidation and DNA breakdown products generated during DNA damage in the blood serum of multiple myeloma and lymphoma patients.Material & Methods: Case control study comprised of 40 patients of multiple myeloma and 20 patients of lymphoma along with 20 age and sex-matched healthy subjects as controls. Levels of Malondialdehyde and 8-hydroxy-2-deoxy-Guanosine were measured to study the oxidative stress status in the study subjects.Results: The level of markers of DNA damage and lipid peroxidation were found to be raised significantly in the study subjects in comparison to healthy controls. The results indicate oxidative stress and DNA damage activity increase progressively with the progression of disease.Conclusion: Oxidative stress causes DNA damage and Lipid peroxidation which results in the formation of DNA adducts leading to mutations thereby indicate the role of oxidative stress in the pathogenesis of multiple myeloma and lymphoma.

Published
2013

4. Markers of Oxidative Stress in Generalized Anxiety Psychiatric Disorder: Therapeutic Implications

Author

Khanna, Ranjana, Negi, Reena, Pande, Deepti, Khanna, Shruti, and Khanna, Hari

Subjects
lcsh:Biochemistry, anxiety disorders, Oxidative damage, lcsh:QD415-436, anti- anxiety therapy
Abstract

There is growing evidence that oxidative stress contributes to the pathogenesis of anxiety disorders. Our aim was to measure oxidative stress in anxiety disorders subjects, and assesses the potential confounding influences of anti anxiety therapy. Serum malondialdehyde and antioxidant levels were estimated in patients at the time of presentation and also after anti- anxiety therapy for 3 months. During the period of study no antioxidant/s was given to the patients and control subjects. Serum malondialdehyde levels were significantly higher in the anxiety disorders patients in comparison to control cases. Also, the antioxidant activity of enzymes super oxide dismutase, glutathione and non enzymatic antioxidant levels of vitamins E and C were significantly lower in patients compared to controls at the initial presentation. After 3 months of anti anxiety treatment all the above parameters showed reversal in the respective levels of serum malondialdehyde and antioxidant activity. Anti anxiety medications results in reduced oxidative stress which indicates that oxidative stress is not the cause, but rather a consequence, of anxiety disorders.

Published
2012

5. Oxidation of Valine by N-Bromophthalimide in Presence of Chloro-Complex of Pd(II) as Homogenous Catalyst: A Kinetic and Mechanistic Study

Author

Katre Yokraj, Negi Reena, Singh Ajaya Kumar, Jain Bhawana, and Singh S.P.

Subjects
Stereochemistry, Kinetics, General Chemistry, Rate equation, Catalysis, Phthalimide, Reaction rate, chemistry.chemical_compound, Reaction rate constant, chemistry, Ionic strength, Physical chemistry, Stoichiometry
Abstract

Kinetics of Pd(II) catalyzed oxidation of valine has been studied by N-bromophthalimide (NBP) in acidic me- dium at 303 K. The reaction follows first order kinetics with respect to (Pd(II)) while negative effect was observed for the variation of (H + ) on the rate of reaction. The reaction exhibits first order kinetics with respect to (NBP) at its lower con- centrations and tends towards zero order at its higher concentrations. Rate of reaction exhibits zero order and fractional order kinetics with respect to (valine) and (Cl - ) respectively. (Hg(OAc)2), (phthalimide), ionic strength (I) and dielectric constant of the medium did not bring about any significant change on the rate of reaction. The rate constants observed at five different temperatures (298 K-318 K) were utilized to calculate the activation parameters. A plausible mechanism has been proposed from the results of kinetic studies, reaction stoichiometry and product analysis.

Published
2009

11. A novel approach to study oxidative stress in neonatal respiratory distress syndrome.

Author

Negi R, Pande D, Karki K, Kumar A, Khanna RS, and Khanna HD

Abstract

Background: Respiratory distress syndrome of the neonate (neonatal RDS) is still an important problem in treatment of preterm infants. It is accompanied by inflammatory processes with free radical generation and oxidative stress. The aim of study was to determine the role of oxidative stress in the development of neonatal RDS., Methods: Markers of oxidative stress and antioxidant activity in umbilical cord blood were studied in infants with neonatal respiratory distress syndrome with reference to healthy newborns., Results: Status of markers of oxidative stress (malondialdehyde, protein carbonyl and 8-hydroxy-2-deoxy guanosine) showed a significant increase with depleted levels of total antioxidant capacity in neonatal RDS when compared to healthy newborns., Conclusion: The study provides convincing evidence of oxidative damage and diminished antioxidant defenses in newborns with RDS. Neonatal RDS is characterized by damage of lipid, protein and DNA, which indicates the augmentation of oxidative stress., General Significance: The identification of the potential biomarker of oxidative stress consists of a promising strategy to study the pathophysiology of neonatal RDS.

Published
2014
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