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6. Meta-analysis of the association between MALAT1 rs619586 A>G polymorphism and cancer risk

Author

Sun Yuqi, Ni Wenwen, Gao Xueren, and Wang Xinyu

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, China, Lung Neoplasms, Adenocarcinoma of Lung, Biochemistry, Polymorphism, Single Nucleotide, Metastasis, polymorphism, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, cancer, Humans, Genetic Predisposition to Disease, Metastasis associated lung adenocarcinoma transcript 1, risk, MALAT1, business.industry, Biochemistry (medical), Liver Neoplasms, Cell Biology, General Medicine, medicine.disease, Long non-coding RNA, 030104 developmental biology, 030220 oncology & carcinogenesis, Meta-analysis, Adenocarcinoma, ethnicity, Cancer risk, business, Meta-Analysis
Abstract

Objective This study aimed to systematically assess the effect of the metastasis associated lung adenocarcinoma transcript 1 ( MALAT1) long noncoding RNA rs619586 polymorphism on cancer risk. Methods We conducted a literature search of the PubMed, Embase, and China National Knowledge Internet databases to identify relevant studies, and calculated the pooled odds ratios (ORs) and 95% confidence intervals (CIs) for the retrieved studies using RevMan software. Results Nine eligible studies including 5968 cases and 7439 controls were included in the meta-analysis. The pooled results showed that MALAT1 rs619586 polymorphism was significantly associated with cancer risk [(AG + GG) vs. AA: OR = 0.88; GG vs. (AG + AA): OR = 0.64; GG vs. AA: OR = 0.63; AG vs. AA: OR = 0.91; G vs. A: OR = 0.87]. However, subgroup analyses based on ethnicity and cancer type showed significant associations between MALAT1 rs619586 polymorphism and cancer risk in Asians and for cancers other than hepatocellular carcinoma, but not for Caucasians and hepatocellular carcinoma. Conclusions MALAT1 rs619586 polymorphism may play a role in cancer risk. However, further studies are needed to confirm these findings.

Published
2020

8. Meta-analysis of the association between MALAT1rs619586 A>G polymorphism and cancer risk

Author

Ni, Wenwen, Wang, Xinyu, Sun, Yuqi, and Gao, Xueren

Abstract

Objective This study aimed to systematically assess the effect of the metastasis associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding RNA rs619586 polymorphism on cancer risk.Methods We conducted a literature search of the PubMed, Embase, and China National Knowledge Internet databases to identify relevant studies, and calculated the pooled odds ratios (ORs) and 95% confidence intervals (CIs) for the retrieved studies using RevMan software.Results Nine eligible studies including 5968 cases and 7439 controls were included in the meta-analysis. The pooled results showed that MALAT1rs619586 polymorphism was significantly associated with cancer risk [(AG + GG) vs. AA: OR = 0.88; GG vs. (AG + AA): OR = 0.64; GG vs. AA: OR = 0.63; AG vs. AA: OR = 0.91; G vs. A: OR = 0.87]. However, subgroup analyses based on ethnicity and cancer type showed significant associations between MALAT1rs619586 polymorphism and cancer risk in Asians and for cancers other than hepatocellular carcinoma, but not for Caucasians and hepatocellular carcinoma.Conclusions MALAT1rs619586 polymorphism may play a role in cancer risk. However, further studies are needed to confirm these findings.

Published
2020
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