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BACKGROUND: Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce. METHODS: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-a (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models. RESULTS: None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR = 1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR = 1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI. CONCLUSION: Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer. British Journal of Cancer (2012) 106, 1866-1874. doi:10.1038/bjc.2012.172 www.bjcancer.com Published online 26 April 2012 (C) 2012 Cancer Research UK

In order to evaluate the applicability of the magnetic resonance sounding method (MRS) in the Danish context and its accuracy in estimating the hydraulic conductivity of different sedimentary aquifers, three MRS campaigns were conducted in Denmark between 2003 and 2007. In total, 12 sites were investigated. At two sites, it was impossible to measure with MRS due to the high level of ambient electromagnetic noise. For the present study, MRS results from 10 investigated sites throughout Denmark are used. A simplified classification of the grain-size within the investigated aquifers was established, based on a geological description of available borehole data. MRS-obtained parameters, water content (theta(MRS)) and decay time (T-1), as well as normalised values of the MRS hydraulic conductivity estimator (K-MRS(n)), from 23 MRS stations were compared with the aquifer class defined by geological description of adjacent boreholes. The comparison revealed a qualitative correlation. Moreover, K-MRS(n) results revealed variations in the hydraulic conductivity within the investigated areas. The observed variations may suggest preferential locations for water-supply boreholes. Further MRS measurements close to boreholes with detailed grain-size analyses and pumping tests are required for a more quantitative estimation. To cite this article: K. Chalikakis et al., C R. Geoscience 341 (2009).

Intensive geophysical measurements are currently being carried out in Denmark to comply with the Danish Government's environmental plans of dense hydrogeological mapping to ensure high quality non-treated drinking water supply based solely on groundwater. A MRS-TDEM combined geophysical survey was conducted to measure the applicability and the contribution of MRS to running drilling programs. Despite complicated electromagnetic noise conditions, the MRS method proved to be applicable in the Danish context. An example of the practical application of MRS combined with TDEM in two selected areas of the former County of Vejle in Denmark, demonstrates the efficiency of the technique. The MRS results clearly suggest optimal locations for water supply boreholes within subsurface structures with homogeneous resistivity conditions mapped by TDEM. These results reveal the interest of using MRS as a new geophysical tool for the Danish water supply policy, which can provide a foundation for optimising drilling site locations within areas with resistivities in the aquifer range. However, more MRS soundings need to be carried out in order to improve MRS calibration in the Danish context, which will allow quantitative MRS characterization of aquifers.