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22 results on '"Noh, Yun-Hee"'

2. Evaluation of the Cross-Protective Efficacy of a Chimeric PRRSV Vaccine against Two Genetically Diverse PRRSV2 Field Strains in a Reproductive Model

Author

Jeong, Chang-Gi, primary, Khatun, Amina, additional, Nazki, Salik, additional, Kim, Seung-Chai, additional, Noh, Yun-Hee, additional, Kang, Sang-Chul, additional, Lee, Dong-Uk, additional, Yang, Myeon-Sik, additional, Shabir, Nadeem, additional, Yoon, In-Joong, additional, Kim, Bumseok, additional, and Kim, Won-Il, additional

Published
2021
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4. Heterogeneity in Liver Histopathology Is Associated With GSK-3β Activity and Mitochondrial Dysfunction in End-Stage Diabetic Rats on Differential Diets

Author

Lee, Jun-Ho, primary, Choi, Soo-Bong, additional, Sung, Dong-Jun, additional, Jin, Mingli, additional, Lee, Ju-Han, additional, Mun, Ji-Young, additional, Hwang, Tae-Sook, additional, Han, Sang-Don, additional, Ro, Young-Tae, additional, Kim, Sung-Young, additional, You, Jueng-Soo, additional, Lim, Inja, additional, and Noh, Yun-Hee, additional

Published
2020
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9. Phenotypic and genotypic analyses of an attenuated porcine reproductive and respiratory syndrome virus strain after serial passages in cultured porcine alveolar macrophages

Author

Lee, Seung-Chul, primary, Lee, Sunhee, additional, Yoo, Gun-Woo, additional, Choi, Hwan-Won, additional, Noh, Yun-Hee, additional, Park, Chang Eon, additional, Shin, Jae-Ho, additional, Yoon, In-Joong, additional, Kang, Shien-Young, additional, and Lee, Changhee, additional

Published
2018
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19. Clinical Impacts of Tumor Cell Contamination of Hematopoietic Stem Cell Products in Metastatic Breast Cancer Patients undergoing Autologous Peripheral Blood Stem Cell Transplantation: Multicenter Trial

Author

Ahn, Myung Ju, primary, Noh, Yun Hee, additional, Lee, Yong Sung, additional, Lee, Young Yeul, additional, Choi, Il Young, additional, Kim, In Soon, additional, Joh, Eun Kyung, additional, Shin, Dong Bock, additional, Kim, Si Young, additional, Cho, Kyung Sam, additional, Kim, Hyo Cheul, additional, Kim, Hyun Soo, additional, Suh, Cheol Won, additional, Kim, Sang Hee, additional, Lee, Jung Ae, additional, and Park, Young Suck, additional

Published
2001
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21. Effects of hydrogen peroxide on voltage-dependent K(+) currents in human cardiac fibroblasts through protein kinase pathways.

Author

Bae H, Lee D, Kim YW, Choi J, Lee HJ, Kim SW, Kim T, Noh YH, Ko JH, Bang H, and Lim I

Abstract

Human cardiac fibroblasts (HCFs) have various voltage-dependent K(+) channels (VDKCs) that can induce apoptosis. Hydrogen peroxide (H2O2) modulates VDKCs and induces oxidative stress, which is the main contributor to cardiac injury and cardiac remodeling. We investigated whether H2O2 could modulate VDKCs in HCFs and induce cell injury through this process. In whole-cell mode patch-clamp recordings, application of H2O2 stimulated Ca(2+)-activated K(+) (KCa) currents but not delayed rectifier K(+) or transient outward K(+) currents, all of which are VDKCs. H2O2-stimulated KCa currents were blocked by iberiotoxin (IbTX, a large conductance KCa blocker). The H2O2-stimulating effect on large-conductance KCa (BKCa) currents was also blocked by KT5823 (a protein kinase G inhibitor) and 1 H-[1, 2, 4] oxadiazolo-[4, 3-a] quinoxalin-1-one (ODQ, a soluble guanylate cyclase inhibitor). In addition, 8-bromo-cyclic guanosine 3', 5'-monophosphate (8-Br-cGMP) stimulated BKCa currents. In contrast, KT5720 and H-89 (protein kinase A inhibitors) did not block the H2O2-stimulating effect on BKCa currents. Using RT-PCR and western blot analysis, three subtypes of KCa channels were detected in HCFs: BKCa channels, small-conductance KCa (SKCa) channels, and intermediate-conductance KCa (IKCa) channels. In the annexin V/propidium iodide assay, apoptotic changes in HCFs increased in response to H2O2, but IbTX decreased H2O2-induced apoptosis. These data suggest that among the VDKCs of HCFs, H2O2 only enhances BKCa currents through the protein kinase G pathway but not the protein kinase A pathway, and is involved in cell injury through BKCa channels.

Published
2016
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22. Topological network analysis of differentially expressed genes in cancer cells with acquired gefitinib resistance.

Author

Lee YS, Hwang SG, Kim JK, Park TH, Kim YR, Myeong HS, Kwon K, Jang CS, Noh YH, and Kim SY

Subjects
Cell Line, Tumor, Cluster Analysis, Computational Biology, Gefitinib, Gene Expression Profiling, Humans, Molecular Sequence Annotation, Neoplasms drug therapy, Neoplasms metabolism, Protein Interaction Mapping, Protein Interaction Maps, Quinazolines therapeutic use, Signal Transduction, Transcriptome, Antineoplastic Agents pharmacology, Drug Resistance, Neoplasm genetics, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Neoplasms genetics, Protein Kinase Inhibitors pharmacology, Quinazolines pharmacology
Abstract

Background/aim: Despite great effort to elucidate the process of acquired gefitinib resistance (AGR) in order to develop successful chemotherapy, the precise mechanisms and genetic factors of such resistance have yet to be elucidated., Materials and Methods: We performed a cross-platform meta-analysis of three publically available microarray datasets related to cancer with AGR. For the top 100 differentially expressed genes (DEGs), we clustered functional modules of hub genes in a gene co-expression network and a protein-protein interaction network. We conducted a weighted correlation network analysis of total DEGs in microarray dataset GSE 34228. The identified DEGs were functionally enriched by Gene Ontology (GO) function and KEGG pathway., Results: We identified a total of 1,033 DEGs (510 up-regulated, 523 down-regulated, and 109 novel genes). Among the top 100 up- or down-regulated DEGs, many genes were found in different types of cancers and tumors. Through integrative analysis of two systemic networks, we selected six hub DEGs (Pre-B-cell leukemia homeobox1, Transient receptor potential cation channel subfamily C member 1, AXL receptor tyrosine kinase, S100 calcium binding protein A9, S100 calcium binding protein A8, and Nucleotide-binding oligomerization domain containing 2) associated with calcium homeostasis and signaling, apoptosis, transcriptional regulation, or chemoresistance. We confirmed a correlation of expression of these genes in the microarray dataset., Conclusion: Our study may lead to comprehensive insights into the complex mechanism of AGR and to novel gene expression signatures useful for further clinical studies., (Copyright© 2015, International Institute of Anticancer Research (Dr. John G. Delinasios), All rights reserved.)

Published
2015

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