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3 results on '"Nurre, Emily"'

1. Infections and the relationship to treatment in neuromuscular autoimmunity

Author

Prior, Devin E, Nurre, Emily, Roller, Stephanie L, Kline, David, Panara, Ramit, Stino, Amro M, Davis, John A, Freimer, Miriam L., and Arnold, W. David

Subjects
Adult, Aged, 80 and over, Male, Incidence, Autoimmunity, Comorbidity, Plasmapheresis, Middle Aged, Infections, Article, Dermatomyositis, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Adrenal Cortex Hormones, Myasthenia Gravis, Humans, Female, Immunosuppressive Agents, Aged, Retrospective Studies
Abstract

INTRODUCTION: This study aimed to identify infections in patients with myasthenia gravis, dermatomyositis and chronic inflammatory demyelinating polyradiculoneuropathy and investigate the relationship between infection and immunomodulation. METHODS: A retrospective chart review examined 631 patients with myasthenia gravis (n=358), chronic inflammatory demyelinating polyradiculoneuropathy (n=124), and dermatomyositis (n=149) patients over a 10 year time period. RESULTS: Infection rates were similar at approximately 19% in all three diseases. Of the infections in which a causative organism was identified, pneumonia, sepsis, and opportunistic infections were leading diagnoses. A multivariate model demonstrated a significant association between infection and an increased dose of plasma exchange, mycophenolate mofetil, and corticosteroid therapy. DISCUSSION: There are few large studies investigating rates of infections in patients with autoimmune neuromuscular disorders and the relationship to immunomodulation. This study not only demonstrates the remarkably similar infection rates across the three diseases studied, but also shows their relationship to commonly used immunotherapies.

Published
2017

3. Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes.

Author

Foust, Kevin D, Nurre, Emily, Montgomery, Chrystal L, Hernandez, Anna, Chan, Curtis M, and Kaspar, Brian K

Subjects
*ADENOVIRUSES, *NEURONS, *ASTROCYTES, *BLOOD-brain barrier, *CENTRAL nervous system, *GENETIC transduction, *TREATMENT of neurodegeneration, *GENE therapy
Abstract

Delivery of genes to the brain and spinal cord across the blood-brain barrier (BBB) has not yet been achieved. Here we show that adeno-associated virus (AAV) 9 injected intravenously bypasses the BBB and efficiently targets cells of the central nervous system (CNS). Injection of AAV9-GFP into neonatal mice through the facial vein results in extensive transduction of dorsal root ganglia and motor neurons throughout the spinal cord and widespread transduction of neurons throughout the brain, including the neocortex, hippocampus and cerebellum. In adult mice, tail vein injection of AAV9-GFP leads to robust transduction of astrocytes throughout the entire CNS, with limited neuronal transduction. This approach may enable the development of gene therapies for a range of neurodegenerative diseases, such as spinal muscular atrophy, through targeting of motor neurons, and amyotrophic lateral sclerosis, through targeting of astrocytes. It may also be useful for rapid postnatal genetic manipulations in basic neuroscience studies. [ABSTRACT FROM AUTHOR]

Published
2009
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