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3. Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications

Author

Boursier, Jérôme, Canivet, Clémence M., Costentin, Charlotte, Lannes, Adrien, Delamarre, Adèle, Sturm, Nathalie, Le Bail, Brigitte, Michalak, Sophie, Oberti, Frédéric, Hilleret, Marie-Noelle, Irles-Depé, Marie, Fouchard, Isabelle, Hermabessiere, Paul, Barthelon, Justine, Calès, Paul, Cariou, Bertrand, de Ledinghen, Victor, and Roux, Marine

Published
2023
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4. TACE and conformal radiotherapy vs. TACE alone for hepatocellular carcinoma: A randomised controlled trial

Author

Féray, Cyrille, Campion, Loic, Mathurin, Philippe, Archambreaud, Isabelle, Mirabel, Xavier, Bronowicki, Jean Pierre, Rio, Emmanuel, Perret, Christophe, Mineur, Laurent, Oberti, Frédéric, Touchefeu, Yann, Gournay, Jérôme, Regnault, Hélène, Edeline, Julien, Rode, Agnès, Hillion, Patrick, Blanc, Jean Frédéric, Khac, Eric Nguyen, Azoulay, Daniel, Luciani, Alain, Preglisasco, Athena Galetto, Faurel-Paul, Elodie, Auble, Hélène, Mornex, Françoise, and Merle, Philippe

Published
2023
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5. Transient Elastography Accurately Screens for Compensated Advanced Chronic Liver Disease in Patients With Ongoing or Recent Alcohol Withdrawal

Author

Legros, Ludivine, Bardou-Jacquet, Edouard, Turlin, Bruno, Michalak, Sophie, Hamonic, Stéphanie, Le Gruyer, Antonia, Aziz, Karim, Lemoine, Cynthia, Bouvard, Nicole, Chavagnat, Jean-Jacques, Silvain, Christine, Kerjean, Jacqueline, Le Dréau, Gérard, Lacave-Oberti, Natacha, Oberti, Frederic, Le Lan, Caroline, Guyader, Dominique, and Moirand, Romain

Published
2022
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6. Early hepatocellular carcinoma detection using magnetic resonance imaging is cost-effective in high-risk patients with cirrhosis

Author

Nahon, Pierre, Asselah, Tarik, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Pageaux, Georges-Philippe, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Decaensi, Thomas, Riachi, Ghassan, Calès, Paul, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Chazouillères, Olivier, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, d’Alteroche, Louis, Wartelle, Claire, Dao, Thông, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Nguyen-Khac, Eric, Bernard-Chabert, Brigitte, Hillaire, Sophie, Di Martino, Vincent, Bonnet, Delphine, Payssan-Sicart, Virginie, Pomes, Chloe, Bailly, François, Beaudoin, Marjolaine, Giboz, Dominique, Hartig-Lavie, Kerstin, Maynard, Marianne, Billaud, Eric, Boutoille, David, Cavellec, Morane, Cheraud-Carpentier, Marjorie, Hubert, Isabelle, Benhida, Jaouad, Lannes, Adrien, Lunel, Françoise, Oberti, Frédéric, Boyer, Nathalie, Giuily, Nathalie, Castelnau, Corinne, Scoazec, Giovanna, Chibah, Aziza, Keser, Sylvie, Bonardi, Karim, Vallet-Pichard, Anaïs, Sogni, Philippe, Foucher, Juliette, Hiriart, Jean-Baptiste, Wilson, Amy, Shili, Sarah, Chermak, Faiza, Ansaldi, Christelle, Ben Amara, Nisserine, Chouquet, Laëtitia, De Luca, Emilie, Oules, Valérie, Anty, Rodolphe, Gelsi, Eve, Truchi, Régine, Luckina, Elena, Messaoudi, Nadia, Moussali, Joseph, De Dieuleveult, Barbara, Labarriere, Damien, Poter, Pascal, Si Ahmed, Si Nafa, Grando-Lemaire, Véronique, Bourcier, Valérie, Brulé, Séverine, Stalhberger, Thomas, Jezequel, Caroline, Brener, Audrey, Laligant, Anne, Rabot, Aline, Renard, Isabelle, Baumert, Thomas F., Dofföel, Michel, Mutter, Catherine, Simo-Noumbissie, Pauline, Razi, Esma, Barraud, Hélène, Bensenane, Mouni, Nani, Abdelbasset, Hassani-Nani, Sarah, Bernard, Marie-Albertine, Bismuth, Michael, Caillo, Ludovic, Faure, Stéphanie, Ripault, Marie Pierre, Bureau, Christophe, Peron, Jean Marie, Robic, Marie Angèle, Tarallo, Léa, Faure, Marine, Froissart, Bruno, Hilleret, Marie-Noelle, Zarski, Jean-Pierre, Goria, Odile, Grard, Victorien, Montialoux, Hélène, François, Muriel, Ouedraogo, Christian, Pauleau, Christelle, Varault, Anne, Andreani, Tony, Angoulevant, Bénédicte, Chevance, Azeline, Serfaty, Lawrence, Antonini, Teresa, Coilly, Audrey, Duclos Vallée, Jean-Charles, Tateo, Mariagrazia, Bonny, Corinne, Brigitte, Chanteranne, Lamblin, Géraldine, Muti, Léon, Babouri, Abdenour, Filipe, Virginie, Barrault, Camille, Costes, Laurent, Hagège, Hervé, Merbah, Soraya, Carrier, Paul, Debette-Gratien, Maryline, Jacques, Jérémie, Lassailly, Guillaume, Artu, Florent, Canva, Valérie, Dharancy, Sébastien, Louvet, Alexandre, Latournerie, Marianne, Bardou, Marc, Mouillot, Thomas, Bacq, Yannick, Barbereau, Didier, Nicolas, Charlotte, Chevalier, Caroline, Archambeaud, Isabelle, Habes, Sarah, Botta-Fridlund, Danièle, Saillard, Eric, Lafrance, Marie-Josée, Cacoub, Patrice, Carrat, Fabrice, Carrieri, Patrizia, Delarocque-Astagneau, Elisabeth, De Ledinghen, Victor, Dorival, Céline, Dubuisson, Jean, Housset, Chantal, Larrey, Dominique, Marcellin, Patrick, Pawlotsky, Jean-Michel, Petrov-Sanchez, Ventzislava, Vaux, Sophie, Wittkop, Linda, Yazdanpanah, Yazdan, Zucman-Rossi, Jessica, Ganne-Carrié, Nathalie, Chaffaut, Cendrine, Moreno, Christophe, Moirand, Romain, Carbonell, Nicolas, Duclos-Vallée, Jean-Charles, de Ledinghen, Victor, Ozenne, Violaine, Henrion, Jean, Perlemuter, Gabriel, Amiot, Xavier, Chevret, Sylvie, Najean, Marie, Layese, Richard, Zarca, Kevin, Segar, Laeticia Blampain, Cagnot, Carole, N’Kontchou, Gisèle, Ronot, Maxime, Audureau, Etienne, and Durand-Zaleski, Isabelle

Published
2022
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7. Impact of cirrhosis aetiology on incidence and prognosis of hepatocellular carcinoma diagnosed during surveillance

Author

Ganne-Carrié, Nathalie, Chaffaut, Cendrine, Archambeaud, Isabelle, d’Alteroche, Louis, Oberti, Frédéric, Roulot, Dominique, Moreno, Christophe, Louvet, Alexandre, Dao, Thông, Moirand, Romain, Goria, Odile, Nguyen-Khac, Eric, Carbonell, Nicolas, Duclos-Vallée, Jean-Charles, Pol, Stanislas, de Ledinghen, Victor, Ozenne, Violaine, Henrion, Jean, Péron, Jean-Marie, Tran, Albert, Perlemuter, Gabriel, Amiot, Xavier, Zarski, Jean-Pierre, Chevret, Sylvie, Nahon, Pierre, Asselah, Tarik, Guyader, Dominique, Fontaine, Hélène, Pageaux, Georges-Philippe, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Bronowicki, Jean-Pierre, Decaens, Thomas, Riachi, Ghassan, Calès, Paul, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Chazouillères, Olivier, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, Wartelle, Claire, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Bernard-Chabert, Brigitte, Hillaire, Sophie, Di Martino, Vincent, N’Kontchou, Gisèle, Layese, Richard, and Audureau, Etienne

Published
2021
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8. Including Ratio of Platelets to Liver Stiffness Improves Accuracy of Screening for Esophageal Varices That Require Treatment

Author

Huvelin, Sylvie Sacher, Calès, Paul, Valla, Dominique, Bureau, Christophe, Olivier, Anne, Oberti, Frédéric, Boursier, Jérôme, Galmiche, Jean Paul, Vinel, Jean Pierre, Duburque, Clotilde, Attar, Alain, Archambeaud, Isabelle, Benamouzig, Robert, Gaudric, Marianne, Luet, Dominique, Couzigou, Patrice, Planche, Lucie, Coron, Emmanuel, Hiriart, Jean-Baptiste, Chermak, Faiza, Charbonnier, Maude, Nahon, Pierre, Marcellin, Patrick, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Larrey, Dominique, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Zarski, Jean-Pierre, Leroy, Vincent, Riachi, Ghassan, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Serfaty, Lawrence, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, Bacq, Yannick, Wartelle, Claire, Dao, Thông, Benhamou, Yves, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Capron, Dominique, Thiefin, Gérard, Hillaire, Sophie, Di Martino, Vincent, Berger, Arthur, Ravaioli, Federico, Farcau, Oana, Festi, Davide, Stefanescu, Horia, Buisson, François, Ganne-Carriè, Nathalie, Berzigotti, Annalisa, de Ledinghen, Victor, and Petta, Salvatore

Published
2021
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9. Criteria to Determine Reliability of Noninvasive Assessment of Liver Fibrosis With Virtual Touch Quantification

Author

Boursier, Jerome, Cassinotto, Christophe, Hunault, Gilles, Shili, Sarah, Lebigot, Jerome, Lapuyade, Bruno, Lannes, Adrien, Hiriart, Jean-Baptiste, Cartier, Victoire, Le Bail, Brigitte, Michalak, Sophie, Mouries, Amaury, Oberti, Frederic, Chermak, Faiza, Fouchard-Hubert, Isabelle, Cales, Paul, Aube, Christophe, and de Ledinghen, Victor

Published
2019
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12. Cross-linkage between bacterial taxonomy and gene functions: a study of metagenome-assembled genomes of Gut Microbiota in adult non-alcoholic fatty liver disease

Author

Canivet, Clemence, David, Norma, Pailhoriès, Helene, Briand, Martial, Guy, Cynthia, Bouchez, Olivier, Hunault, Gilles, Fizanne, Lionel, Lannes, Adrien, Oberti, Frederic, Fouchard, Isabelle, Calès, Paul, Diehl, Anna Mae, Barret, Matthieu, Boursier, Jerome, Département d'hépatologie (CHU Angers), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Institut de Recherche en Horticulture et Semences (IRHS), Université d'Angers (UA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Duke University Medical Center, Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Angers University Hospital, Université d'Angers (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Université Toulouse III - Paul Sabatier (UT3)

Subjects
nutritional and metabolic diseases, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, digestive system, digestive system diseases, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background The reconstruction of metagenome-assembled genomes (MAGs) has emerged as a powerful approach for combining the taxonomic and functional content of microbial populations.Aim To use this new approach to highlight mechanisms linking gut microbiota to NAFLD severityMethods Stool samples were collected from 96 NAFLD patients on the day of liver biopsy. Shotgun DNA sequencing of the gut microbiota was performed on an Illumina HiSeq3000 system. Contigs were binned into MAGs according to their co-abundances and tetranucleotide frequencies using Metabat v.0.32.4. Predicted protein-coding genes were clustered in orthologous groups (OGs) with DIAMOND against the EggNOG v4.5 database. Liver biopsies were read in accordance with the NASH CRN classification.Results Fifty-four patients had NASH and 44 had significant fibrosis (F >= 2). Sequencing of DNA extracted from stools resulted in 13.8 + 3.2 million paired-end reads per sample. Of the 4,000 reconstructed MAGs, 220 in NASH patients, 192 in non-NASH patients, 203 in F >= 2 patients and 230 in F0-1 patients had > 70% completeness and < 5% contamination. Within these MAGs, 28 OGs were associated with NASH, 33 with significant fibrosis, and seven with both NASH and significant fibrosis. The study of MAGs showed associations between NAFLD severity and some gut bacteria with microbiota functions related to hydrogen sulfide production, citrate transport, hemicellulose degradation, aldehyde production and vitamin B12 synthesis.Conclusion Using new metagenomics methods, our study unveils potential mechanisms by which certain bacteria from the gut microbiota could protect or contribute to the development of NASH and liver fibrosis in NAFLD.

Published
2021

14. RADIOLOGICAL AND PATHOLOGICAL RESPONSE TO NEOADJUVANT NIVOLUMAB IN PATIENTS WITH BCLC A HCC TREATED BY CURATIVE PERCUTANEOUS IRREVERSIBLE ELECTROPORATION: PRELIMINARY REPORT FROM THE FRENCH MULTICENTRE PHASE 2 NIVOLEP TRIAL

Author

Nahon, Pierre, Seror, Olivier, Oberti, Frederic, Dimby, Solohaja Faniaha, Aube, Christophe, Blanc, Jean-Frederic, Trillaud, Herve, Merle, Philippe, Rode, Agnès, Assenat, Eric, Guiu, Boris, Bouattour, Mohamed, Talib, Zohra, Tibi, Annick, Calderaro, Julien, Ziol, Marianne, Vicaut, Eric, and DIMBY, SOLOHAJA FANIAHA

Subjects
[SDV.CAN] Life Sciences [q-bio]/Cancer, [STAT.AP] Statistics [stat]/Applications [stat.AP]
Published
2020

15. Cross‐linkage between bacterial taxonomy and gene functions: a study of metagenome‐assembled genomes of gut microbiota in adult non‐alcoholic fatty liver disease

Author

Canivet, Clemence M., primary, David, Norma, additional, Pailhoriès, Helene, additional, Briand, Martial, additional, Guy, Cynthia D., additional, Bouchez, Olivier, additional, Hunault, Gilles, additional, Fizanne, Lionel, additional, Lannes, Adrien, additional, Oberti, Frederic, additional, Fouchard, Isabelle, additional, Calès, Paul, additional, Diehl, Anna Mae, additional, Barret, Matthieu, additional, and Boursier, Jerome, additional

Published
2021
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16. Current management of the complications of portal hypertension: variceal bleeding and ascites

Author

Dib, Nina, Oberti, Frederic, and Cales, Paul

Subjects
Portal hypertension -- Care and treatment, Portal hypertension -- Causes of
Abstract

ABSTRACT Portal hypertension is one of the main consequences of cirrhosis. It results from a combination of increased intrahepatic vascular resistance and increased blood flow through the portal venous system. [...]

Published
2006

18. Direct comparison of the specialised blood fibrosis tests FibroMeterV2G and Enhanced Liver Fibrosis score in patients with non-alcoholic fatty liver disease from tertiary care centres

Author

Guillaume, Maeva, primary, Moal, Valerie, additional, Delabaudiere, Cyrielle, additional, Zuberbuhler, Floraine, additional, Robic, Marie-Angèle, additional, Lannes, Adrien, additional, Metivier, Sophie, additional, Oberti, Frederic, additional, Gourdy, Pierre, additional, Fouchard-Hubert, Isabelle, additional, Selves, Janick, additional, Michalak, Sophie, additional, Peron, Jean-Marie, additional, Cales, Paul, additional, Bureau, Christophe, additional, and Boursier, Jerome, additional

Published
2019
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19. Direct comparison of the specialised blood fibrosis tests FibroMeterV2G and Enhanced Liver Fibrosis score in patients with non‐alcoholic fatty liver disease from tertiary care centres.

Author

Guillaume, Maeva, Moal, Valerie, Delabaudiere, Cyrielle, Zuberbuhler, Floraine, Robic, Marie‐Angèle, Lannes, Adrien, Metivier, Sophie, Oberti, Frederic, Gourdy, Pierre, Fouchard‐Hubert, Isabelle, Selves, Janick, Michalak, Sophie, Peron, Jean‐Marie, Cales, Paul, Bureau, Christophe, and Boursier, Jerome

Subjects
FATTY liver, BLOOD testing, TERTIARY care, FIBROSIS, RECEIVER operating characteristic curves
Abstract

Summary: Background: The Enhanced Liver Fibrosis score (ELF) and the FibroMeterV2G are two specialized blood fibrosis tests which include direct markers of liver fibrosis. They have been shown to be more accurate than the simple blood fibrosis tests FIB4 and the non‐alcoholic fatty liver disease (NAFLD) fibrosis score (NFS). Aims: To directly compare the accuracies of ELF and FibroMeterV2G for the non‐invasive diagnosis of liver fibrosis in NAFLD. Methods: Four hundred and seventeen patients with biopsy‐proven NAFLD were enrolled from two tertiary care centres. Four blood fibrosis tests were calculated: ELF, FibroMeterV2G, NFS, and FIB4. Advanced fibrosis F3/4 on liver biopsy (NASH CRN scoring) was the primary endpoint. Results: Areas under the receiver operating characteristic (AUROC) curve for advanced fibrosis were not significantly different between the direct markers of liver fibrosis (hyaluronate, PIIINP, TIMP‐1, alpha2‐macroglobulin) and the simple blood fibrosis tests NFS and FIB4. ELF (0.793 ± 0.022) and FibroMeterV2G (0.804 ± 0.021) had significantly higher AUROC than NFS (0.722 ± 0.025, P < .010) and FIB4 (0.739 ± 0.024, P < .020). AUROC for advanced fibrosis and Obuchowski index were not significantly different between ELF and FibroMeterV2G. Algorithms using first ELF or FibroMeterV2G and then liver biopsy in case of undetermined diagnosis provided high diagnostic accuracy for advanced fibrosis: 90% sensitivity, 90% specificity, 93% negative predictive value, 85% positive predictive value, and 90% correct classification. In these algorithms, the rate of liver biopsy was 45.3% with ELF versus 39.3% with FibroMeterV2G (P = .065). Conclusions: ELF and FibroMeterV2G have equal accuracy and perform better than the simple FIB4 and NFS tests for the non‐invasive diagnosis of advanced liver fibrosis in patients with NAFLD from tertiary care centres. [ABSTRACT FROM AUTHOR]

Published
2019
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20. LBA-001 - Efficacy, tolerability and impact on quality of life of selective internal radiation therapy (with yttrium-90 resin microspheres) or sorafenib in patients with locally advanced hepatocellular carcinoma: The SARAH trial

Author

Bouattour, Mohamed, Assenat, Eric, Guiu, Boris, Ilonca Alina, Diana, Pageaux, Georges-Philippe, Sibert, Annie, Lebtahi, Rachida, Allaham, Wassim, Barraud, Hélène, Laurent, Valérie, Mathias, Elodie, Bronowicki, Jean-Pierre, Tasu, Jean-Pierre, Perdrisot, Rémy, Silvain, Christine, Gerolami, René, Mundler, Olivier, Seitz, Jean-Francois, Vidal, Vincent, Aubé, Christophe, Oberti, Frédéric, Couturier, Olivier, Brenot-Rossi, Isabelle, Raoul, Jean-Luc, Sarran, Anthony, Costentin, Charlotte, Itti, Emmanuel, Luciani, Alain, Adam, René, Lewin, Maïté, Samuel, Didier, Ronot, Maxime, Dinut, Aurelia, Pereira, Helena, Castera, Laurent, Chatellier, Gilles, and Vilgrain, Valérie

Published
2017
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21. T1013 A Multicentric, Double-Blind, Randomized Placebo-Controlled Trial of High Dose Ursodeoxycholic Acid in Patients with Non-Alcoholic Steatohepatitis (NASH)

Author

Jean Spénard, Claire Wartelle Bladou, Oberti Frederic, Christophe Renou, Victor de Ledinghen, Philippe Mathurin, and Vlad Ratziu

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Placebo-controlled study, Non alcoholic, medicine.disease, Ursodeoxycholic acid, Double blind, Internal medicine, medicine, In patient, Steatohepatitis, business, medicine.drug
Published
2009

24. Direct comparison of the specialised blood fibrosis tests FibroMeter V2G and Enhanced Liver Fibrosis score in patients with non-alcoholic fatty liver disease from tertiary care centres.

Author

Guillaume M, Moal V, Delabaudiere C, Zuberbuhler F, Robic MA, Lannes A, Metivier S, Oberti F, Gourdy P, Fouchard-Hubert I, Selves J, Michalak S, Peron JM, Cales P, Bureau C, and Boursier J

Subjects
Adult, Aged, Female, Humans, Liver Cirrhosis diagnosis, Male, Middle Aged, Non-alcoholic Fatty Liver Disease diagnosis, Tertiary Care Centers, Hematologic Tests, Liver Cirrhosis blood, Non-alcoholic Fatty Liver Disease blood
Abstract

Background: The Enhanced Liver Fibrosis score (ELF) and the FibroMeter V2G are two specialized blood fibrosis tests which include direct markers of liver fibrosis. They have been shown to be more accurate than the simple blood fibrosis tests FIB4 and the non-alcoholic fatty liver disease (NAFLD) fibrosis score (NFS)., Aims: To directly compare the accuracies of ELF and FibroMeter V2G for the non-invasive diagnosis of liver fibrosis in NAFLD., Methods: Four hundred and seventeen patients with biopsy-proven NAFLD were enrolled from two tertiary care centres. Four blood fibrosis tests were calculated: ELF, FibroMeter V2G , NFS, and FIB4. Advanced fibrosis F3/4 on liver biopsy (NASH CRN scoring) was the primary endpoint., Results: Areas under the receiver operating characteristic (AUROC) curve for advanced fibrosis were not significantly different between the direct markers of liver fibrosis (hyaluronate, PIIINP, TIMP-1, alpha2-macroglobulin) and the simple blood fibrosis tests NFS and FIB4. ELF (0.793 ± 0.022) and FibroMeter V2G (0.804 ± 0.021) had significantly higher AUROC than NFS (0.722 ± 0.025, P < .010) and FIB4 (0.739 ± 0.024, P < .020). AUROC for advanced fibrosis and Obuchowski index were not significantly different between ELF and FibroMeter V2G . Algorithms using first ELF or FibroMeter V2G and then liver biopsy in case of undetermined diagnosis provided high diagnostic accuracy for advanced fibrosis: 90% sensitivity, 90% specificity, 93% negative predictive value, 85% positive predictive value, and 90% correct classification. In these algorithms, the rate of liver biopsy was 45.3% with ELF versus 39.3% with FibroMeter V2G (P = .065)., Conclusions: ELF and FibroMeter V2G have equal accuracy and perform better than the simple FIB4 and NFS tests for the non-invasive diagnosis of advanced liver fibrosis in patients with NAFLD from tertiary care centres., (© 2019 John Wiley & Sons Ltd.)

Published
2019
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25. Management of digestive bleeding related to portal hypertension in cirrhotic patients: A French multicenter cross-sectional practice survey.

Author

Ingrand P, Gournay J, Bernard P, Oberti F, Bernard-Chabert B, Pauwels A, Renard P, Bartoli E, Cadranel JF, Barbare JC, Ingrand I, and Beauchant M

Subjects
Adrenergic beta-Antagonists therapeutic use, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, France, Gastrointestinal Hemorrhage physiopathology, Health Care Surveys, Humans, Hypertension, Portal drug therapy, Hypertension, Portal physiopathology, Hypertension, Portal prevention & control, Ligation, Liver Cirrhosis diagnosis, Liver Cirrhosis physiopathology, Male, Middle Aged, Practice Guidelines as Topic, Practice Patterns, Physicians', Prospective Studies, Vasoconstrictor Agents therapeutic use, Gastrointestinal Hemorrhage etiology, Gastrointestinal Hemorrhage therapy, Guideline Adherence, Hypertension, Portal complications, Liver Cirrhosis complications
Abstract

Aim: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines., Methods: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals., Results: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers for early vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers., Conclusion: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved.

Published
2006
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26. Hepatocyte nuclear factor-1 alpha gene inactivation: cosegregation between liver adenomatosis and diabetes phenotypes in two maturity-onset diabetes of the young (MODY)3 families.

Author

Reznik Y, Dao T, Coutant R, Chiche L, Jeannot E, Clauin S, Rousselot P, Fabre M, Oberti F, Fatome A, Zucman-Rossi J, and Bellanne-Chantelot C

Subjects
Adenoma pathology, Adolescent, Adult, Family Health, Female, Genetic Testing, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta, Humans, Liver pathology, Liver Neoplasms pathology, Male, Middle Aged, Pedigree, Phenotype, Adenoma genetics, DNA-Binding Proteins, Diabetes Mellitus, Type 2 genetics, Liver Neoplasms genetics, Nuclear Proteins, Transcription Factors genetics
Abstract

Heterozygous germline mutations of the hepatocyte nuclear factor (HNF)-1 alpha are associated with maturity-onset diabetes of the young (MODY)3. Recently, the biallelic inactivation of the HNF-1 alpha gene was reported in liver adenomas. We show the occurrence of liver adenomatosis in six MODY3-affected patients from two unrelated and large families. Liver adenomatosis was characterized by the presence of numerous adenomas within a normal hepatic parenchyma. The HNF-1 alpha hot-spot germline mutation P291fs was identified in the two probands and in 16 relatives from the two families. The six patients affected by liver adenomatosis and diabetes exhibited the mutation. The analysis of liver-cell tumors from two affected patients evidenced the biallelic inactivation of HNF-1 alpha. The familial screening confirmed the clinical heterogeneity of the liver phenotype, from silent liver adenomatosis to fatal hemorrhage. These observations warrant the systematic screening for liver adenomatosis in MODY3 families to prevent its potentially deadly complications. Moreover, such screening may help to determine if a particular mutational spectrum of HNF-1 alpha is associated with liver adenomatosis and to establish its prevalence in this frequent form of diabetes in the young adult.

Published
2004
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