33 results on '"Onur Taşar"'
Search Results
2. The effects of coronary artery disease severity on left atrial deformation parameters in patients with stable coronary artery disease
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Arzu Kalaycı, Can Yücel Karabay, Onur Taşar, Servet İzci, Çetin Geçmen, Vecih Oduncu, İbrahim Akın İzgi, and Cevat Kırma
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diastolic dysfunction ,left atrial strain ,syntax score. ,Medicine ,Internal medicine ,RC31-1245 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objectives: Aim of the present study was to investigate correlation between left atrial (LA) deformation parameters assessed using 2-dimensional (2D) speckle tracking echocardiography (STE) and complexity of coronary artery disease according to SYNTAX score (SXscore) in patients with stable coronary artery disease (SCAD). Study design: Total of 60 moderate-risk SCAD patients (40 men, 20 women) who underwent coronary angiography and 30 healthy controls were included. Measurements of conventional echocardiographic parameters as well as peak LA strain during ventricular systole (LA-RES), peak LA strain during atrial systole (LA-PUMP), peak LA strain rate during ventricular systole (LA-SRS), peak LA strain rate during early diastole (LA-SRE), and peak LA strain rate during atrial systole (LA-SRA) were obtained. Results: Patients were categorized into 2 groups: low SXscore of
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- 2017
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3. Gender-related differences in presentation and treatment of patients with non-valvular atrial fibrillation: results from RAMSES study
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Volkan Doğan, Özcan Başaran, Osman Beton, Mehmet Tekinalp, Ahmet Çağrı Aykan, Ezgi Kalaycıoğlu, İsmail Bolat, Onur Taşar, Özgen Şafak, Macit Kalçık, Cevat Kırma, and Murat Biteker
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gender ,non-valvular atrial fibrillation ,oral anticoagulan therapy. ,Medicine ,Internal medicine ,RC31-1245 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: Gender is an important feature in the management of atrial fibrillation (AF). This study investigated gender-related differences in patients with AF in Turkey. Methods: As a part of RAMSES (ReAl-life Multicenter Survey Evaluating Stroke prevention strategies in Turkey, NCT02344901) study, information of the patients with AF who successively applied to the hospital was analyzed. This cross-sectional, multicenter, nationwide observational study enrolled 6264 non-valvular AF (NVAF) outpatients (55.9% women) from Turkey. Results: Compared with men, women with NVAF were older (71 years [range: 65–78 years] vs. 70 years [range: 62–77 years]; p
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- 2017
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4. Predictive role of left atrial and ventricular mechanical function in postoperative atrial fibrillation: a two-dimensional speckle-tracking echocardiography study
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Özcan Başaran, Kursat Tigen, Gokhan Gozubuyuk, Cihan Dundar, Ahmet Guler, Onur Taşar, Murat Biteker, Can Yücel Karabay, Mustafa Bulut, Tansu Karaahmet, and Cevat Kırma
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atrial fibrillation ,coronary artery disease ,left atrial strain ,left ventricular strain ,speckle tracking echocardiography. ,Medicine ,Internal medicine ,RC31-1245 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: The aim of this study was to determine the role of leftsided mechanical parameters in postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass grafting (CABG). Methods: Ninety patients with coronary artery disease and normal left ventricular (LV) function in sinus rhythm were enrolled in the study. Preoperative LV and left atrial (LA) mechanics were evaluated by two-dimensional (2D) speckle-tracking echocardiography (STE), including strain and rotation parameters, and volume indices. Patients were monitored in order to detect POAF during the postoperative period. Results: Twenty-three of 90 patients (25.6%) developed POAF. Age (p70 pg/ml, OR 22.377, CI 3.286–152.381, p
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- 2016
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5. Comparison of One Year Outcomes of Subintimal Versus Intraluminal Recanalization in Femoropopliteal Chronic Total Occlusions: Single Center Experience from Anatolia
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Onur Taşar and Koray Kalenderoğlu
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Cardiology and Cardiovascular Medicine - Published
- 2020
6. One-Year Outcomes of Femoropopliteal Chronic Total Occlusions Treated With Percutaneous Provisional Approach: A Single Center Experience (Percutaneous Treatment of Femoropopliteal CTO)
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Koray Kalenderoglu and Onur Taşar
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medicine.medical_specialty ,Percutaneous ,business.industry ,Medicine ,business ,Single Center ,Surgery - Published
- 2019
7. Percutaneous coronary angiography and intervention via transpalmar access for the first time in Turkey
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Sedat Kalkan, Onur Taşar, and Koray Kalenderoglu
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Coronary angiography ,medicine.medical_specialty ,ulnar artery ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Percutaneous ,business.industry ,transpalmar access ,Surgery ,lcsh:RC666-701 ,Intervention (counseling) ,medicine ,coronary angiography ,Cardiology and Cardiovascular Medicine ,business - Abstract
Unstable angina is common in ischemic heart diseases. Patients with unstable angina undergo coronary angiography to detect lesions that may require treatment. Coronary angiography can be performed through several ways of arterial access. Radial access is the most commonly used method. We report a 71 year old male patient who presented with chest pain due to unstabil angina pectoris. Coronary angiograhy was perfomed by a new technique, transpalmar access through superficial palmar branch of the ulnar artery. The patient was treated successfully with percutaneous coronary intervention of the left anterior descending artery. In our case, transpalmar approach was performed for the first time in Turkey.
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- 2020
8. Evaluation of Aortic Distensibility by Echocardiography and Applanation Tonometry in Patients with Mitral Valve Prolapse
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Can Yücel Karabay, Sedat Kalkan, Süleyman Çağan Efe, Onur Taşar, and Cevat Kirma
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0301 basic medicine ,Applanation tonometry ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Population ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Internal medicine ,Healthy control ,cardiovascular system ,medicine ,Cardiology ,Mitral valve prolapse ,In patient ,Heart valve ,Aortic diameter ,Cardiology and Cardiovascular Medicine ,education ,business ,Pulse wave velocity ,030217 neurology & neurosurgery - Abstract
Objective Mitral valve prolapse (MVP) is a heart valve anomaly that affects a considerable segment of the population. Studies of patients with isolated MVP have shown that aortic distensibility decreased as the aortic diameter increased. The aim of this study was to compare evaluations of aortic distensibility in MVP patients using both applanation tonometry and the conventional echocardiographic examination. Methods A total of 36 consecutive patients with MVP (16 male and 20 female) and 23 healthy controls (11 male and 12 female) were included in this study. The difference in aortic diameter and distensibility was examined using echocardiography and pulse wave velocity (PWV) was measured with applanation tonometry. Results According to the echocardiographic measurements, the aortic distensibility was lower in the MVP patients than in the control group (6.2±4.0 cm².dyn⁻¹.10⁻⁶ vs. 10.0±5.2 cm². dyn⁻¹.10⁻⁶; p=0.02). The PWV measured with applanation tonometry was significantly higher in the MVP patients than in the control group (9.0±2.4 m/s vs. 7.2±1.4 m/s; p=0.006). Conclusion The results of this study showed that aortic distensibility was reduced in patients with isolated MVP compared with a healthy control group. There was a moderate negative correlation between the results of both methods.
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- 2020
9. Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study
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Onur Taşar, Cevat Kirma, Arzu Kalayci Karabay, Gonenc Kocabay, Yavuz Karabağ, Sedat Kalkan, and Can Yücel Karabay
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medicine.medical_specialty ,Original Paper ,business.industry ,medicine.medical_treatment ,Fibrous cap ,percutaneous coronary intervention ,insulin-like growth factor-1 levels ,Percutaneous coronary intervention ,Infarction ,medicine.disease ,Insulin-like growth factor ,medicine.anatomical_structure ,Internal medicine ,Conventional PCI ,Coronary stent ,medicine ,Cardiology ,Medicine ,myocardial injury ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,Complication ,business - Abstract
Introduction Periprocedural myocardial necrosis, which can range from a low level elevation of cardiac biomarkers to a large myocardial infarction (MI), is a common complication after percutaneous coronary intervention (PCI). Aim We hypothesized that insulin-like growth factor-1 (IGF-1) levels may play a protective role in myocardial injury after coronary stent placement and aimed to investigate the relationship between IGF-1 levels and plaque characteristics assessed by optical coherence tomography (OCT). Material and methods Between May 2015 and December 2015 we prospectively enrolled 74 patients with stable angina pectoris in whom single de novo coronary artery stenosis was present. PCI was performed according to standard methods. OCT was applied to all patients. TnT was analyzed at admission, before PCI and at 6, 12, 24 and 48 h after PCI. Serum IGF-1 was measured prior to PCI. Results A total of 25 (33.7%) patients had periprocedural myocardial injury or type 4a myocardial infarction, and 49 (66.2%) patients had no events. IGF-1 level and reference intimal thickness, medial thickness, and plaque fibrous cap thickness in OCT had strong correlations (r = 0.88, 0.80 and 0.88 respectively, p < 0.001). IGF-1 was an independent predictor of periprocedural myocardial injury or type 4a MI in univariate (OR = 0.929, 95% CI: 0.895-0.964, p < 0.001) and multivariate regression analysis (OR = 0.757, 95% CI: 0.575-0.998, p = 0.04). Based on ROC analysis, the best cut-off value of IGF-1 for predicting periprocedural myocardial injury or type 4a myocardial infarction was 144.5 ng/ml, with a maximum sensitivity of 88% and specificity of 77.6% (AUC = 0.80, 95% CI: 0.69-0.88, p < 0.0001). Conclusions The results from this study indicate that low IGF-1 levels are associated with plaque instability assessed by OCT. Low IGF-1 levels may identify patients who are at increased risk for periprocedural myocardial injury/infarction.
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- 2019
10. Alteration of Pregnant Women Heart Mechanics Assessed by Speckle Tracking Echocardiography During Pregnancy
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İbrahim Akın İzgi, Onur Taşar, Gonenc Kocabay, Ali Karagöz, Şeyhmus Külahçıoğlu, Bünyamin Şan, Arzu Kalayci, Tahir Bezgin, and Cevat Kirma
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Gynecology ,Two-dimensional speckle tracking echocardiography,strain,pregnancy ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,business.industry ,lcsh:R ,lcsh:Medicine ,2 boyutlu speckle tracking ekokardiyografi,strain,gebelik ,Tıp ,strain ,lcsh:RC666-701 ,Medicine ,pregnancy ,Two-dimensional speckle tracking echocardiography ,business - Abstract
Introduction:Thepurpose of this study was to evaluate left ventricular myocardial mechanicsusing 2-dimensional speckle tracking echocardiography (2D-STE) during normal,uncomplicated pregancy and postpartum term.Patientsand Methods: In this prospective, longitudinal study, 86 healthypregnant women who underwent serial 2 dimensional echocardiographic evaluationduring each trimester (trimester one 8-12 weeks; trimester two 20-24 weeks,trimester three 32-36 weeks, and postpartum 10-14 weeks). Two-dimensional STEwas performed to measure global left ventricular longitudinal, circumferential,and radial strain (GLS, GCS, and GRS, respectively).Results: GLS showeda decrease during pregnancy (for first trimester 21.0 ± 2.1%; for secondtrimester 19.9 ± 1.8%; for third trimester 18.2 ± 2.1; for postpartum 19.1 ±1.4, p< 0.001). GCS was significantly reduced during pregnancy (p= 0.033)and peaked as the same value in the first trimester. GRS remained unchangedthroughout the pregnancy and labor (p= 0.033).Conclusion: This study gives normalranges of 2D indices in pregnancy. 2D STE demonstrated that LV longitudinal andcircumferantial strain are significantly reduced, whereas radial strainremained unchanged., Giriş: Bu çalışmanın amacı sağlıklı gebelerde, gebelik süresince ve sonrasında solventrikül fonksiyonlarındaki değişimi “iki boyutlu speckle trackingekokardiyografi (STE)” yöntemi ile araştırmaktır.Hastalar veYöntem: Çalışmaya 86 sağlıklı gebe dahil edilmiş ve gebeliğinbirinci trimester 8-12 hafta, ikinci trimester 20-24 hafta, üçüncü trimester32-36 hafta ve postpartum 10-14. haftada 2 boyutlu ekokardiyografi ilekayıtları alınmıştır. Sol ventrikül global longitüdinal strain (SV-GLS), solventrikül global radiyal strain (SV-GRS), sol ventrikül global sirkumferansiyelstrain (SV-GCS) değerleri not edilmiştir. Bulgular: SV-GLS birinci trimester için -%21.0 ± 2.1; ikinci. trimester için -%19.9 ±1.8; üçüncü trimester için -%18.2 ± 2.1; postpartum -%19.1 ± 1.4, p< 0.001).SV-GCS gebelik boyunca anlamlı olarak azalırken (p= 0.033), post partum dönemde1.ci trimesterde bulunan değerlerine yükseldi. SV-GRS değerlerinde gebelikboyunca değişiklikler istatistiksel olarak anlamlı bulunmadı (p= 0.103).Sonuç: Bu çalışmada STE iledeğerlendirilen, SV-GLS ve SV-GCS ile mekanik fonksiyonlarının anlamlı birşekilde değiştiğini ve SV-GRS’de bir değişim olmadığını saptadık.
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- 2017
11. Optical coherence tomography guided successful fibrinolytic treatment without the need for percutaneous coronary intervention in a patient with acute ST-segment elevation myocardial infarction
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Can Yücel Karabay, Mehmet Emin Kalkan, Arzu Kalayci, Gonenc Kocabay, Onur Taşar, and Cevat Kirma
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Acute ST segment elevation myocardial infarction ,medicine.medical_treatment ,Percutaneous coronary intervention ,Text mining ,Optical coherence tomography ,Image in Intervention ,Internal medicine ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
12. Increased Remnant Cholesterol Blood Concentration Associated with First Acute Coronary Syndrome
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Rezzan Deniz Acar, Nihal Özdemir, Emrah Erdoğan, Cihangir Kaymaz, Zübeyde Bayram, Onur Taşar, Cem Doğan, and Murat Çap
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lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Acute coronary syndrome ,business.industry ,lcsh:R ,lcsh:Medicine ,medicine.disease ,Cholesterol blood ,Tıp ,remnant cholesterol ,triglyceride-rich lipoproteins ,lcsh:RC666-701 ,Internal medicine ,medicine ,Cardiology ,Acute coronary syndrome,remnant cholesterol,triglyceride-rich lipoproteins ,Medicine ,lipids (amino acids, peptides, and proteins) ,Akut koroner sendrom,kalıntı kolesterol,trigliseritten zengin lipoproteinler ,business - Abstract
Giriş: Açlık dışıkalıntı kolesterolün artması, artmış düşük dansiteli lipoprotein kolesterol(LDL-C) gibi iskemik kardiyovasküler hastalıklar için artmış risk ileilişkilidir. Çalışmamızın amacı, ilk kez akut koroner sendrom (AKS) ile gelenhastalarda kalıntı kolesterol ve akut koroner sendromun arasındaki ilişkiyiaraştırmaktır. Hastalar ve Yöntem:İlk kez akut koroner sendrom ile başvuran 226 hasta ve normal koroner arterolarak sonuçlanmış 192 elektif koroner anjiyografi hastasında, diğer lipitprofili parametrelerinin yanı sıra, açlık dışı kalıntı kolesterolün artankonsantrasyonlarını karşılaştırdık. Bulgular: AKShastaları kontrol grubu ile karşılaştırıldığında erkek cinsiyet fazla, dahagenç ve daha fazla oranda diabetes mellitus mevcuttu (tümü için p< 0.001).AKS hastalarında glukoz ve beyaz kan hücresi düzeyleri de daha yüksekti.Kalıntı kolesterol, LDL-C değerine benzer şekilde, AKS grubunda istatistikselolarak kontrol grubu ile karşılaştırıldığında daha yüksekti (p< 0.001). Tekdeğişkenli ve çok değişkenli ikili lojistik regresyon analizinde yüksek kankalıntı kolesterolü, yüksek kan LDL-C değerleri ve düşük kan HDL-C değerleriile akut koroner sendromlar arasında anlamlı bir ilişki mevcuttu. Sonuç: Çalışmamız,yüksek kan LDL-C seviyelerinde olduğu gibi artmış kalıntı kolesteroldüzeylerinin artmış ilk kez yaşanılan AKS riski ile ilişkili olduğunugöstermiştir. AKS hastalarında LDL-C düzeylerinin düşürülmesinin yanı sırakalıntı kolesterol düzeylerinin düşürülmesi üzerine daha fazla çalışmayapılmalı ve odaklanılmalıdır., Introduction: Thisstudy aimed to investigate the association between remnant cholesterol andacute coronary syndrome (ACS) and its predictive value for acute coronarysyndrome occurring for the first time. Patients and Methods:We compared increasing concentrations of non-fasting remnant cholesterol asidefrom other lipid profile parameters to investigate this association in 226patients with ACS for the first time and 192 elective coronary angiographypatients with normal coronary arteries. Results: Patientswith ACS were mostly males and were younger than those in the control group;moreover, they had higher percentage of diabetes mellitus (for all p
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- 2019
13. Rationale, design and methodology of the EPIC (Epidemiology of Polypharmacy and potential drug-drug Interactions in elderly Cardiac outpatients) study
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Özgen Şafak, Oğuzhan Çelik, Zeki Şimşek, Lütfü Bekar, Hacı Murat Güneş, Çağatay Önal, Cem Çil, Bugra Ozkan, Yunus Çelik, Halil İbrahim Özdemir, Murat Biteker, Volkan Doğan, Caner Kaçmaz, Eda Özlek, Özcan Başaran, Veysel Ozan Tanık, Edip Güvenç Çekiç, Onur Taşar, Bülent Özlek, Kırıkkale Üniversitesi, MÜ, and [Belirlenecek]
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Kardiyak Hastalar ,Research design ,lcsh:Internal medicine ,lcsh:Diseases of the circulatory (Cardiovascular) system ,drug-drug interactions ,medicine.medical_specialty ,Heart Diseases ,Potentially Inappropriate Medication List ,Cardiac outpatients ,Polifarmasi ,Beers Criteria ,lcsh:Medicine ,Drug-Drug Interactions ,elderly ,Elderly ,Ambulatory care ,Epidemiology ,Ambulatory Care ,medicine ,Humans ,Drug Interactions ,Cardiac Outpatients ,polypharmacy ,lcsh:RC31-1245 ,Aged ,Aged, 80 and over ,Polypharmacy ,Clinical Trials as Topic ,business.industry ,Medical record ,lcsh:R ,[No Keywords] ,Cardiovascular Agents ,Research Design ,lcsh:RC666-701 ,Emergency medicine ,Observational study ,Yaşlılık ,Cardiology and Cardiovascular Medicine ,business ,İlaç-İlaç Etkileşimleri - Abstract
Objective: The aim of this study is to assess the prevalence of polypharmacy, inappropriate drug use, and drug-drug interactions (DDIs) in elderly patients presenting at outpatient cardiology clinics in Turkey. Methods: The EPIC (Epidemiology of Polypharmacy and Potential Drug-Drug Interactions in Elderly Cardiac Outpatients) study will be an observational, real-world, multicenter study conducted to evaluate DDIs and polypharmacy in elderly cardiac outpatients. All consecutive patients (aged ?65 years) admitted to outpatient cardiology clinics between July 30, 2018 and July 30, 2019 who provide written, informed consent will be enrolled. A total of approximately 5000 patients are to be enrolled in this non-interventional study. All of the data will be collected at one point in time and current clinical practice will be evaluated (ClinicalTrials.gov NCT03370523). Results: Patient demographics, comorbid disease characteristics, laboratory test results, and details of medication use will be collected using self-reports and medical records. The severity of comorbid disease will be recorded and scored according to Charlson Comorbidity Index (CCI) and patients will be divided into 3 groups: mild, those with a CCI score of 1–2; moderate, those with a CCI score of 3–4; and severe, those with a CCI score of ?5. Polypharmacy will be defined as the use of 5 or more medications at one time. DDIs will be determined using the Lexicomp Online drug interaction screening tool and potentially inappropriate medications will be defined based on the 2015 update of the Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. Severe drug interactions will be defined as those in category D or X. Conclusion: EPIC will be the first large-scale study in Turkey to evaluate polypharmacy, potentially inappropriate medications, and DDIs in elderly cardiac outpatients in a real-world clinical setting. Amaç: Türkiye’deki kardiyoloji polikliniklerine başvuran yaşlı hastalarda polifarmasi prevalansını, uygunsuz ilaç kullanımını ve ilaç-ilaç etkileşimlerini (İİE) değerlendirmek. Yöntemler: EPIC (Epidemiology of Polypharmacy and Potential Drug-Drug Interactions in Elderly Cardiac Outpatients) çalışması kardiyoloji polikliniklerine başvuran yaşlı hastalarda polifarmasi ve İİE’nin değerlendirileceği, gerçek yaşam verilerini aktaran, çok merkezli ve gözlemsel bir çalışma olarak tasarlandı. Çalışmaya; 30 Temmuz 2018 ve 30 Temmuz 2019 tarihleri arasında farklı kardiyoloji polikliniklerine başvuran, aydınlatılmış onam formunu imzalayan, 65 yaş ve üzeri, kadın ve erkek, ardışık 5000 hastanın dahil edilmesi planlandı. Hastalarla ilgili tüm verilerin tek bir ziyarette alınması ve verilerin değerlendirilmesi planlandı (ClinicalTrials.gov numarası NCT03370523). Bulgular: Hastalara ait demografik veriler, komorbid hastalık durumları, laboratuvar test sonuçları ve ilaç bilgileri hasta beyanları ve medikal kayıtlar yoluyla toplanacaktır. Komorbid hastalıklar kaydedilecek ve komorbid hastalıkların ciddiyeti Charlson komorbidite indeksi’ne (CKİ) göre hastalar 3 gruba ayrılacaktır: CKİ skoru 1–2 olanlar hafif, CKİ skoru 3–4 olanlar orta, CKİ skoru ?5 olanlar ciddi. Polifarmasi aynı hastanın bir kerede 5 ve üzeri ilaç kullanması olarak tanımlanacaktır. İİE Lexicomp® çevrimiçi ilaç etkileşimi tarama aracı ile kontrol edilecek, potansiyel uygunsuz ilaç kullanımı 2015 Beers kriterlerine göre tanımlanacaktır. D ve X kategorisindeki etkileşimler ciddi ilaç etkileşimi olarak sınıflandırılacaktır. Sonuç: EPIC çalışması kardiyoloji polikliniklerine başvuran yaşlı hastalarda polifarmasi, İİE ve potansiyel uygunsuz ilaç kullanımı konularında gerçek yaşam verilerini ayrıntılı olarak aktaran ilk büyük çaplı çalışma olacaktır. WOS:000475438700008 2-s2.0-85068799852 PubMed: 31311898
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- 2019
14. Demographic, clinical characteristics and medications of rehospitalized patients for acute coronary syndrome: boomerang study
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Batur Gonenc Kanar, Arash Hashemi, Patrick W.J. Tiau, Aysel Akhundova, Fady Gerges, Seyyad Farshad Sadri, Sinan Inci, Tuğba Kemaloğlu Öz, Irina Kotlar, Mustafa Dogdus, Yagoub Musa, Onur Taşar, Fatemeh Nikroo, Yusuf Cekici, Lütfü Bekar, Mesut Gitmez, Tarık Kıvrak, Emrah Aksakal, Mahmoud Abdelnabi, Hakki Kaya, Fatih Tamnik, Abdallah Almaghraby, Gobinda Kanti Paul, Shafa Shahbazova, Meltem Altınsoy, Mehdi Zoghi, Mustafa Yenerçağ, Fadime Bozdurman, Bilal Cuglan, Begum Uygur, İbrahim Ersoy, Ayman Helal, and Mehtap Yeni
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rehospitalization ,Cardiovascular event ,Acute coronary syndrome ,medicine.medical_specialty ,Coronary event ,business.industry ,Atypical chest pain ,medicine.disease ,Chest pain ,acute coronary syndrome ,Taking medication ,demographics ,RC666-701 ,Internal medicine ,Diabetes mellitus ,medicine ,Diseases of the circulatory (Cardiovascular) system ,medication ,Myocardial infarction ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,clinical characteristics - Abstract
Background: Rehospitalizations with acute coronary syndromes (ACSs) have declined over the last years, but there is a remaining need for potential further reduction of rehospitalization after ACS to determine the most predominant predictors that can guide strategies to reduce re-hospitalizations burden. Aim: This multi-center study aimed to evaluate the demographic, clinical characteristics, and medications of rehospitalized patients who suffered a new cardiac event in 12 months after admission due to ACS. Material and Methods: Patients age >18 years who have been hospitalized between November 1 2017, and April 1 2018, for ACS within12 months before the readmission for a new acute coronary event were enrolled. Results: The present study included a total of 628 (65.9% from Turkey) consecutive patients rehospitalized with ACS (ST-elevation myocardial infarction [STEMI], 23.0%; ACS without ST-elevation [NSTE-ACS], 76.9%) from 15 different countries. The majority of the rehospitalized patients were men (67.9%), and the mean age was 63.1 ± 12.53 years. 406 (64.6%) had typical, 209 (33.2%) of patients had atypical chest pain and 13 (2.07%) had not any chest pain complaint during readmission. 304 (48.41%) of patients were discharged from hospital earlier than 3 days and 107 (17.04%) of patients stayed more than 7 days. The subcategories of first index diagnosis were 227 (36.1%) STEMI; 401 (63.8%) NSTE-ACS. The mean time from index discharge to rehospitalization was 189.25 ± 118 days. 248 (39.4%) patients were re-hospitalized more than once after index discharge. The most common risk factors were diabetes mellitus (471, 75.0%). 175 (27.87%) of patients stopped taking medication before re-hospitalization. Most of the patients (69.4%) had multivessel disease. Conclusion: Several factors identify patients at higher risk of rehospitalization with ACS. Understanding and preventing these causes can prevent rehospitalization and improve their outcome.
- Published
- 2021
15. ReAl-life Multicenter Survey Evaluating Stroke prevention strategies in non-valvular atrial fibrillation (RAMSES study)
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Özcan Başaran, Mehmet Yaman, Ahmet Çağrı Aykan, Mehmet Tekinalp, Ibrahim Altun, Volkan Doğan, Macit Kalçık, Özgen Şafak, Osman Beton, Onur Taşar, Murat Biteker, Ezgi Kalaycıoğlu, Ismail Bolat, Mustafa Özcan Soylu, Cevat Kirma, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Başaran, Özcan, Doğan, Volkan, Biteker, Murat, [Basaran, Ozcan -- Dogan, Volkan -- Altun, Ibrahim -- Soylu, Mustafa Ozcan -- Biteker, Murat] Mugla Sitki Kocman Univ, Fac Med, Dept Cardiol, Mugla, Turkey -- [Beton, Osman] Sivas Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey -- [Tekinalp, Mehmet] Kahramanmaras Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkey -- [Aykan, Ahmet Cagri -- Kalaycioglu, Ezgi] Trabzon Ahi Evren Chest Cardiovasc Surg Educ & Re, Dept Cardiol, Trabzon, Turkey -- [Bolat, Ismail] Fethiye State Hosp, Dept Cardiol, Fethiye, Turkey -- [Tasar, Onur] Elazig Educ & Res Hosp, Dept Cardiol, Elazig, Turkey -- [Safak, Ozgen] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Kalcik, Macit] Iskilip Atif Hoca State Hosp, Dept Cardiol, Corum, Turkey -- [Yaman, Mehmet] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Kirma, Cevat] Kartal Kosuyolu Heart Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey, Demir, Vahit -- 0000-0001-8349-6651, and BASARAN, OZCAN -- 0000-0002-6384-6455
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medicine.medical_specialty ,Turkey ,Non valvular atrial fibrillation ,Administration, Oral ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,prevention ,Risk Factors ,Internal medicine ,Surveys and Questionnaires ,Atrial Fibrillation ,medicine ,Humans ,Oral Anticoagulant Therapy ,Medical history ,030212 general & internal medicine ,Stroke ,Aged ,Aged, 80 and over ,Mitral regurgitation ,Univariate analysis ,business.industry ,Prevention ,Hot Topic ,Anticoagulants ,Atrial fibrillation ,oral anticoagulant therapy ,Middle Aged ,medicine.disease ,stroke ,Cross-Sectional Studies ,Stroke prevention ,Multicenter survey ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
WOS: 000392195800004, PubMed ID: 27723665, Objective: Data regarding stroke prevention strategies in non-valvular atrial fibrillation (NVAF) are limited to vitamin K antagonists (VKAs). This study aimed to evaluate real-life stroke prevention strategies for NVAF patients in the era of non-VKA oral anticoagulants (NOACs). Methods: We established a cross-sectional, multicenter, nationwide registry of NVAF patients. All consecutive atrial fibrillation (AF) patients and without mechanical heart valves or rheumatic mitral stenosis (but including those with any degree of mitral regurgitation) were enrolled in the ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies (RAMSES Study; ClinicalTrials. gov identifier NCT02344901) in Turkey. Base-line demographic data, medical history, and medications prescribed for NVAF treatment were collected. Univariate analyses were performed for continuous variables, and the chi-square test was used for categorical variables. Results: In total, 6273 patients from 29 provinces of Turkey were enrolled in the study between February and May 2015, with the contribution of 83 investigators. The mean age was 69.6 +/- 10.7 years; 56% of the patients were females, and one-fifth of the patients had at least one comorbid disease, the most common being hypertension (69%). The mean CHA(2)DS(2)-VASc and HAS-BLED scores were 3.3 +/- 1.6 and 1.6 +/- 1.1, respectively. The rate of oral anticoagulant (OAC) therapy use was 72% (37% NOAC and 35% VKA). Conclusion: The RAMSES study showed a higher prevalence of OAC use among NVAF patients than that reported in previous studies. Although NOACs were preferred over VKAs in daily cardiology practice, there is a need for improved OAC therapies for NVAF patients.
- Published
- 2016
16. Predictive role of left atrial and ventricular mechanical function in postoperative atrial fibrillation: a two-dimensional speckle-tracking echocardiography study
- Author
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Gökhan Gözübüyük, Tansu Karaahmet, Cevat Kirma, Ahmet Guler, Onur Taşar, Kursat Tigen, Murat Biteker, Özcan Başaran, Cihan Dündar, M Bulut, and Can Yücel Karabay
- Subjects
Male ,medicine.medical_specialty ,lcsh:Internal medicine ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Heart Ventricles ,Adrenergic beta-Antagonists ,lcsh:Medicine ,Speckle tracking echocardiography ,Coronary Artery Disease ,Coronary artery disease ,Postoperative Complications ,Predictive Value of Tests ,Internal medicine ,Natriuretic Peptide, Brain ,medicine ,Humans ,Sinus rhythm ,atrial fibrillation ,Heart Atria ,Prospective Studies ,Coronary Artery Bypass ,Prospective cohort study ,lcsh:RC31-1245 ,Aged ,E/A ratio ,business.industry ,lcsh:R ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Peptide Fragments ,medicine.anatomical_structure ,Echocardiography ,lcsh:RC666-701 ,Predictive value of tests ,Cardiology ,Atrial Function, Left ,Female ,coronary artery disease ,left atrial strain ,left ventricular strain ,speckle tracking echocardiography ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
Objective: The aim of this study was to determine the role of leftsided mechanical parameters in postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass grafting (CABG). Methods: Ninety patients with coronary artery disease and normal left ventricular (LV) function in sinus rhythm were enrolled in the study. Preoperative LV and left atrial (LA) mechanics were evaluated by two-dimensional (2D) speckle-tracking echocardiography (STE), including strain and rotation parameters, and volume indices. Patients were monitored in order to detect POAF during the postoperative period. Results: Twenty-three of 90 patients (25.6%) developed POAF. Age (p70 pg/ml, OR 22.377, CI 3.286–152.381, p
- Published
- 2016
17. Confounding Factors About Microvolt T-wave Alternans Testing And Life Threatening Ventricular Arrhytmias
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Onur Taşar and Hacer Ceren Tokgoz
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Confounding ,Cardiology ,Medicine ,T wave alternans ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
18. Assessment of the relationship between reperfusion success and T-peak to T-end interval in patients with ST elevation myocardial infarction treated with percutaneous coronary intervention
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İbrahim Rencüzoğulları, Yavuz Karabağ, Onur Taşar, İnanç Artaç, Süleyman Karakoyun, Süleyman Çağan Efe, Yalçın Velibey, Doğan İliş, Halil İbrahim Tanboğa, Metin Çağdaş, and Mahmut Yesin
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Sensitivity and Specificity ,Sudden cardiac death ,Electrocardiography ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Postoperative Complications ,0302 clinical medicine ,Heart Conduction System ,St elevation myocardial infarction ,Internal medicine ,medicine ,Humans ,Repolarization ,ST segment ,T-peak–T-end interval ,cardiovascular diseases ,030212 general & internal medicine ,Aged ,Original Investigation ,medicine.diagnostic_test ,business.industry ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,reperfusion ,Treatment Outcome ,ST elevation myocardial infarction ,ROC Curve ,Cardiology ,No-Reflow Phenomenon ,Population study ,Female ,no-reflow ,Electrical conduction system of the heart ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objective: T-peak–T-end (TPE) interval, which represents the dispersion of repolarization, is defined as the interval between the peak and end of the T-wave, and is associated with increased malignant ventricular arrhythmia and sudden cardiac death (SCD) in patients with ST elevation myocardial infarction (STEMI). Although prolonged TPE interval is associated with poor short- and long-term outcomes, even in patients with STEMI treated with successful primary percutaneous coronary intervention (pPCI), clinical, angiographic, and laboratory parameters that affect TPE remain to be elucidated. The aim of our study was to evaluate the potential relationship between prolonged TPE interval and reperfusion success using ST segment resolution (STR) in patients with STEMI undergoing pPCI. Methods: In the current study, 218 consecutive patients with STEMI who underwent pPCI were enrolled; after exclusion, 164 patients were included in the study population. Results: Patients were divided into two groups according to the presence of complete (STR%≥70) or incomplete (STR%
- Published
- 2018
19. Relationship between R-wave peak time and no-reflow in ST elevation myocardial infarction treated with a primary percutaneous coronary intervention
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İbrahim Rencüzoğulları, İnanç Artaç, Mahmut Yesin, Metin Çağdaş, Yavuz Karabağ, Mahmut Uluganyan, Süleyman Karakoyun, Süleyman Çağan Efe, Onur Taşar, Mustafa Ozan Gürsoy, Doğan İliş, and ULUGANYAN, MAHMUT
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Coronary Angiography ,Electrocardiography ,03 medical and health sciences ,QRS complex ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Coronary Circulation ,Internal medicine ,Humans ,Medicine ,ST segment ,030212 general & internal medicine ,Myocardial infarction ,cardiovascular diseases ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Percutaneous coronary intervention ,General Medicine ,Thrombolysis ,Middle Aged ,Prognosis ,medicine.disease ,Coronary vessel ,No reflow phenomenon ,Cardiology ,cardiovascular system ,No-Reflow Phenomenon ,ST Elevation Myocardial Infarction ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Coronary no-reflow (NR) is observed in nearly half of ST segment elevation myocardial infarction (STEMI) patients who undergo a primary percutaneous coronary intervention (pPCI) despite epicardial coronary vessel patency. Several methods used to define NR include thrombolysis in myocardial infarction grade, corrected thrombolysis in myocardial infarction frame count, myocardial blush grade, ST-segment resolution, contrast echocardiography, and MRI. The aim of our study was to evaluate the relationship between NR and R-wave peak time (RWPT) measured from infarct-related artery leads METHOD: We enrolled 282 consecutive STEMI patients treated with pPCI in Kafkas University Hospital from January 2014 to January 2015. After exclusion, the remaining 233 patients were included in the study population RESULTS: Patients were divided into two groups according to the development of NR. We observed that increased preprocedural (31 (27-37) vs 27 (21-30) p
- Published
- 2017
20. [The effects of coronary artery disease severity on left atrial deformation parameters in patients with stable coronary artery disease]
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Vecih Oduncu, Servet İzci, İbrahim Akın İzgi, Arzu Kalaycı, Can Yücel Karabay, Cevat Kirma, Çetin Geçmen, and Onur Taşar
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Male ,medicine.medical_specialty ,lcsh:Internal medicine ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Diastole ,lcsh:Medicine ,Speckle tracking echocardiography ,Coronary Artery Disease ,Coronary artery disease ,Ventricular Dysfunction, Left ,Left atrial ,syntax score ,Internal medicine ,medicine ,Humans ,In patient ,Heart Atria ,lcsh:RC31-1245 ,Aged ,Cardiac cycle ,left atrial strain ,business.industry ,lcsh:R ,Case-control study ,Middle Aged ,medicine.disease ,lcsh:RC666-701 ,Echocardiography ,Case-Control Studies ,Cardiology ,diastolic dysfunction ,Female ,Cardiology and Cardiovascular Medicine ,Scad ,business - Abstract
Objectives: Aim of the present study was to investigate correlation between left atrial (LA) deformation parameters assessed using 2-dimensional (2D) speckle tracking echocardiography (STE) and complexity of coronary artery disease according to SYNTAX score (SXscore) in patients with stable coronary artery disease (SCAD). Study design: Total of 60 moderate-risk SCAD patients (40 men, 20 women) who underwent coronary angiography and 30 healthy controls were included. Measurements of conventional echocardiographic parameters as well as peak LA strain during ventricular systole (LA-RES), peak LA strain during atrial systole (LA-PUMP), peak LA strain rate during ventricular systole (LA-SRS), peak LA strain rate during early diastole (LA-SRE), and peak LA strain rate during atrial systole (LA-SRA) were obtained. Results: Patients were categorized into 2 groups: low SXscore of
- Published
- 2017
21. Gender-related differences in presentation and treatment of patients with non-valvular atrial fibrillation: results from RAMSES study
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Macit Kalçık, Volkan Doğan, Osman Beton, Mehmet Tekinalp, Özgen Şafak, Ahmet Çağrı Aykan, Özcan Başaran, Cevat Kirma, Ezgi Kalaycıoğlu, Ismail Bolat, Onur Taşar, Murat Biteker, MÜ, [Dogan, Volkan -- Basaran, Ozcan -- Biteker, Murat] Mugla Sitki Kocman Univ, Dept Cardiol, Fac Med, Mugla, Turkey -- [Beton, Osman] Sivas Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkey -- [Tekinalp, Mehmet] Kahramanmaras Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkey -- [Aykan, Ahmet Cagri -- Kalaycioglu, Ezgi] Trabzon Ahi Evren Chest Cardiovasc Surg Training, Dept Cardiol, Trabzon, Turkey -- [Bolat, Ismail] Fethiye State Hosp, Dept Cardiol, Mugla, Turkey -- [Tasar, Onur] Elazig Training & Res Hosp, Dept Cardiol, Elazig, Turkey -- [Safak, Ozgen] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Kalcik, Macit] Iskilip Atif Hoca State Hosp, Dept Cardiol, Corum, Turkey -- [Kirma, Cevat] Kartal Kosuyolu Heart Training & Res Hosp, Dept Cardiol, Istanbul, Turkey, and BASARAN, OZCAN -- 0000-0002-6384-6455
- Subjects
Male ,lcsh:Internal medicine ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Turkey ,Cross-sectional study ,Non valvular atrial fibrillation ,lcsh:Medicine ,Management of atrial fibrillation ,030204 cardiovascular system & hematology ,Non-Valvular Atrial Fibrillation ,Severity of Illness Index ,oral anticoagulan therapy ,Brain Ischemia ,Coronary artery disease ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Risk Factors ,non-valvular atrial fibrillation ,Internal medicine ,Atrial Fibrillation ,Severity of illness ,gender ,medicine ,Humans ,030212 general & internal medicine ,Practice Patterns, Physicians' ,lcsh:RC31-1245 ,Stroke ,Aged ,business.industry ,lcsh:R ,Age Factors ,Anticoagulants ,Gender ,Middle Aged ,medicine.disease ,Oral Anticoagulan Therapy ,Cross-Sectional Studies ,lcsh:RC666-701 ,Heart failure ,Cardiology ,Female ,Observational study ,Cardiology and Cardiovascular Medicine ,business - Abstract
WOS: 000396440200005, PubMed ID: 28106016, Objective: Gender is an important feature in the management of atrial fibrillation (AF). This study investigated gender-related differences in patients with AF in Turkey. Methods: As a part of RAMSES (ReAl-life Multicenter Survey Evaluating Stroke prevention strategies in Turkey, NCT02344901) study, information of the patients with AF who successively applied to the hospital was analyzed. This cross-sectional, multi-center, nationwide observational study enrolled 6264 non-valvular AF (NVAF) outpatients (55.9% women) from Turkey. Results: Compared with men, women with NVAF were older (71 years [range: 65-78 years] vs. 70 years [range: 62-77 years]; p= 1 [male], >= 2 [female]) had not received any anticogulant therapy. Conclusion: Although women with NVAF receive better treatment than men, anticoagulation therapy is suboptimal in large proportion of men and women, with underuse in high-risk patients and overuse in low-risk patients. There is an urgent need to improve optimization of anticoagulation in patients with NVAF.
- Published
- 2017
22. Complete aortic prosthetic valve dehiscence after modified Bentall-De Bono procedure
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Arzu Kalayci, Onur Taşar, Cevat Kirma, and Can Yücel Karabay
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medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,business.industry ,Complete dehiscence ,Dehiscence ,Chest pain ,medicine.disease ,prosthetic valve ,Surgery ,Aortic aneurysm ,Aortic valve replacement ,lcsh:RC666-701 ,Infective endocarditis ,medicine ,cardiovascular system ,endocarditis ,Ventricular outflow tract ,Cardiac skeleton ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Coronary sinus - Abstract
A 56-year-old male patient was admitted to our clinic due to persistent fever despite the use of antibiotics for 2 weeks, chest pain, and presyncope. His medical history revealed that the patient underwent modified Bentall-De Bono procedure 2 months ago due to ascending aortic aneurysm and severe aortic insufficiency. Transthoracic apical 5 chamber view showed that mobile vegetation prolapsed into the left ventricular outflow tract during ventricular diastole and that mechanical prosthetic valve was superior to the aortic annulus. Transesophageal echocardiography revealed normal aortic mechanical prosthetic valve function; however, the valve was positioned more superior to the annular plane and a dense vegetation was observed. Moreover, a complete dehiscence of the prosthetic valve was attached to aortic annulus with a single stitch in an area between noncoronary sinus and left coronary sinus. Dense thrombus formation was observed in the perivalvular region. Many cases with prosthetic valve endocarditis and partial dehiscence as its complication have been reported in the literature. However, to the best of our knowledge, there is no reported case of complete dehiscence secondary to infective endocarditis following complete ascending aortic graft and prosthetic aortic valve replacement (modified Bentall-De Bono procedure).
- Published
- 2018
23. Correlation of B-type natriuretic peptide with severity of coronary artery disease assessed by SYNTAX score ii in st elevation acute coronary syndrome patients
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Onur Taşar, Yavuz Karabağ, Metin Çağdaş, and Gonenc Kocabay
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lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Acute coronary syndrome ,medicine.drug_class ,business.industry ,ST elevation ,Area under the curve ,medicine.disease ,b-type natriuretic peptide ,acute coronary syndrome ,Coronary artery disease ,lcsh:RC666-701 ,Diabetes mellitus ,Internal medicine ,Troponin I ,medicine ,Cardiology ,Natriuretic peptide ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,coronary artery disease ,Killip class - Abstract
Background: We aimed to evaluate the role of B-type natriuretic peptide (BNP) in assessing severity of coronary artery disease by SYNTAX score (SS) II in a prospective study among ST elevation acute coronary syndrome (ACS) patients. Methods: One thousand and six patients with ST elevation myocardial infarction (STEMI) who admitted for primary percutaneous intervention were included. The patients were divided into two groups according to SS II values (≤32 and >32). The independent predictors of high SS II were investigated, and the best cutoff value of BNP, high-sensitivity C-reactive protein (hs-CRP), peak troponin I, and hemoglobin level in predicting high SS II was determined.Results: There was a positive correlation between BNP, white blood cell, hs-CRP, fasting blood glucose, peak troponin I, and SS I. SS II and hemoglobin were negative, but other parameters were positively correlated. High SS II group independent predictors of hypertension, diabetes mellitus, smoking, multivessel disease, high Killip class, BNP, peak troponin I, hemoglobin, and hs-CRP levels were found in STEMI patients. The value of BNP >87.15 pg/ml with 59% sensitivity and 77% specificity (area under the curve [AUC]: 0.722 [95% confidence interval [CI]: 0.689–0.756], P < 0.001), hs-CRP >10.85 mg/dl with 64% sensitivity and 64% specificity (AUC: 0.685 [95% CI: 0.65–0.72], P < 0.001), peak troponin I >77.83 ng/mL with 68% sensitivity and 63% specificity (AUC: 0.704 [95% CI 0.67–0.738], P < 0.001), and hemoglobin >16.75 g/dL with 4% sensitivity and 97% specificity (AUC: 0.345 [95% CI: 0.309–0.382] P < 0.001) independently predicted high SS II group. Conclusion: Serum BNP level was independently associated with the severity of coronary atherosclerosis in patients with ACS together with multivessel disease, left ventricular ejection fraction, hs-CRP, and troponin. Therefore, BNP assessment gives additional prognostic information for early risk stratification of patients with ACS.
- Published
- 2019
24. Relation Between Left Ventricular Diastolic Function and Arterial Stiffness in Patients with Bicuspid Aortic Valve
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Ahmet Güler, Alev Kilicgedik, Ruken Bengi Bakkal, Taylan Akgun, Serdar Demir, Gonenc Kocabay, Can Yücel Karabay, Akin Izgi, Süleyman Çağan Efe, Cevat Kirma, Sedat Kalkan, Arzu Kalayci, and Onur Taşar
- Subjects
medicine.medical_specialty ,business.industry ,medicine.disease ,Bicuspid aortic valve ,Leaflet formation ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,Arterial stiffness ,Aortic stiffness ,Diastolic function ,In patient ,cardiovascular diseases ,business ,Cardiology and Cardiovascular Medicine - Abstract
PP-234 Bicuspid aortic valve (BAV) is the result of abnormal aortic leaflet formation during valvulogenesis. Recently, it has been shown that BAV is associated with abnormal aortic stiffness, which has a negative impact on left ventricular (LV) diastolic function. The purpose of this study was to
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- 2013
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25. Demographic, clinical characteristics and medications of rehospitalized patients for acute coronary syndrome: boomerang study
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Tugba Kemaloglu Oz, Tarik Kivrak, Abdallah Almaghraby, Mahmoud Abdelnabi, Onur Tasar, Begum Uygur, Emrah Aksakal, Gobinda Kanti Paul, Seyyad Farshad Sadri, Fatemeh Nikroo, Yagoub Musa, Batur Kanar, Hakki Kaya, Fady Gerges, Yusuf Cekici, Arash Hashemi, Bilal Cuglan, Lutfu Bekar, Irina Kotlar, Mustafa Yenercag, Mesut Gitmez, Aysel Akhundova, Sinan Inci, Mehtap Yeni, Mustafa Dogdus, Meltem Altinsoy, Ayman Helal, Shafa Shahbazova, Fatih Tamnik, Patrick W J Tiau, Ibrahim Ersoy, Fadime Bozdurman, and Mehdi Zoghi
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acute coronary syndrome ,clinical characteristics ,demographics ,medication ,rehospitalization ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Rehospitalizations with acute coronary syndromes (ACSs) have declined over the last years, but there is a remaining need for potential further reduction of rehospitalization after ACS to determine the most predominant predictors that can guide strategies to reduce re-hospitalizations burden. Aim: This multi-center study aimed to evaluate the demographic, clinical characteristics, and medications of rehospitalized patients who suffered a new cardiac event in 12 months after admission due to ACS. Material and Methods: Patients age >18 years who have been hospitalized between November 1 2017, and April 1 2018, for ACS within12 months before the readmission for a new acute coronary event were enrolled. Results: The present study included a total of 628 (65.9% from Turkey) consecutive patients rehospitalized with ACS (ST-elevation myocardial infarction [STEMI], 23.0%; ACS without ST-elevation [NSTE-ACS], 76.9%) from 15 different countries. The majority of the rehospitalized patients were men (67.9%), and the mean age was 63.1 ± 12.53 years. 406 (64.6%) had typical, 209 (33.2%) of patients had atypical chest pain and 13 (2.07%) had not any chest pain complaint during readmission. 304 (48.41%) of patients were discharged from hospital earlier than 3 days and 107 (17.04%) of patients stayed more than 7 days. The subcategories of first index diagnosis were 227 (36.1%) STEMI; 401 (63.8%) NSTE-ACS. The mean time from index discharge to rehospitalization was 189.25 ± 118 days. 248 (39.4%) patients were re-hospitalized more than once after index discharge. The most common risk factors were diabetes mellitus (471, 75.0%). 175 (27.87%) of patients stopped taking medication before re-hospitalization. Most of the patients (69.4%) had multivessel disease. Conclusion: Several factors identify patients at higher risk of rehospitalization with ACS. Understanding and preventing these causes can prevent rehospitalization and improve their outcome.
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- 2021
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26. Evaluation of aortic distensibility in patients with mitral valve prolapse using echocardiography and applanation tonometry
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Sedat Kalkan, suleyman Efe, Onur Tasar, Can Yucel Karabay, and Cevat Kirma
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aortic distensibility ,mitral valve prolapse ,pulse wave velocity. ,Medicine ,Internal medicine ,RC31-1245 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: Mitral valve prolapse (MVP) is a heart valve anomaly that affects a considerable segment of the population. Studies of patients with isolated MVP have shown that aortic distensibility decreased as the aortic diameter increased. The aim of this study was to compare evaluations of aortic distensibility in MVP patients using both applanation tonometry and the conventional echocardiographic examination. Methods: A total of 36 consecutive patients with MVP (16 male and 20 female) and 23 healthy controls (11 male and 12 female) were included in this study. The difference in aortic diameter and distensibility was examined using echocardiography and pulse wave velocity (PWV) was measured with applanation tonometry. Results: According to the echocardiographic measurements, the aortic distensibility was lower in the MVP patients than in the control group (6.2+-4.0 cm².dyn⁻¹.10⁻⁶ vs. 10.0+-5.2 cm². dyn⁻¹.10⁻⁶; p=0.02). The PWV measured with applanation tonometry was significantly higher in the MVP patients than in the control group (9.0+-2.4 m/s vs. 7.2+-1.4 m/s; p=0.006). Conclusion: The results of this study showed that aortic distensibility was reduced in patients with isolated MVP compared with a healthy control group. There was a moderate negative correlation between the results of both methods.
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- 2020
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27. Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study
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Onur Tasar, Gonenc Kocabay, Yavuz Karabag, Arzu Karabay, Can Yucel Karabay, Sedat Kalkan, and Cevat Kirma
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insulin-like growth factor-1 levels ,myocardial injury ,percutaneous coronary intervention ,Medicine - Published
- 2020
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28. Baseline SYNTAX score and long term outcomes in patients treated with primary percutaneous coronary intervention
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Arzu Kalayci, Vecih Oduncu, Sedat Kalkan, Ahmet Guler, Onur Taşar, Can Yücel Karabay, Taylan Akgun, Akin Izgi, Ayhan Erkol, and Cevat Kirma
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Cardiogenic shock ,Percutaneous coronary intervention ,medicine.disease ,Syntax ,Coronary artery bypass surgery ,Reperfusion therapy ,Internal medicine ,medicine ,Cardiology ,Long term outcomes ,ST segment ,Cardiology and Cardiovascular Medicine ,business ,Baseline (configuration management) - Published
- 2013
29. Baseline red cell distribution width and long term clinical outcomes in patients treated with primary percutaneous coronary intervention
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Vecih Oduncu, Mustafa Akçakoyun, Ayhan Erkol, Taylan Akgun, Cevat Kirma, Olcay Ozveren, Can Yücel Karabay, Ahmet Guler, Onur Taşar, and Arzu Kalayci
- Subjects
Cardiovascular event ,medicine.medical_specialty ,Anemia ,Proportional hazards model ,business.industry ,medicine.medical_treatment ,Cardiogenic shock ,Percutaneous coronary intervention ,Red blood cell distribution width ,medicine.disease ,Surgery ,medicine ,ST segment ,In patient ,Cardiology and Cardiovascular Medicine ,business - Published
- 2013
30. Evaluation of aneurysm after coronary stent implantation by optical coherence tomography
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Onur Taşar, Arzu Kalayci, Ahmet Guler, Gonenc Kocabay, Can Yücel Karabay, and Cevat Kirma
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,Coronary Angiography ,Aneurysm ,Restenosis ,medicine.artery ,Internal medicine ,Coronary stent ,medicine ,Humans ,cardiovascular diseases ,Myocardial infarction ,Thrombus ,Dyslipidemias ,Coronary artery aneurysm ,business.industry ,Coronary Aneurysm ,Coronary Stenosis ,Stent ,Middle Aged ,medicine.disease ,Right coronary artery ,cardiovascular system ,Cardiology ,Stents ,Cardiology and Cardiovascular Medicine ,business ,Tomography, Optical Coherence - Abstract
A 47 year-old man with dyslipidaemia was admitted with acute ST-elevation myocardial infarction of the inferior wall with total occlusion of the right coronary artery (RCA). After the administration of medical treatment, thrombus aspiration was applied to the vessel and a 3.0 × 28 mm bare stent was deployed to the RCA at 18 atm. After the intervention (PCI), coronary angiography (CAG) revealed TIMI flow 3 (Figs. 1A, C). The patient’s clinical status had improved. Six months later, he was admitted to our hospital complaining of atypical chest pain. After an abnormal exercise treadmill stress test, we performed control CAG which showed a coronary artery aneurysm at the stented site without restenosis (Figs. 1B, D). Optical coherence tomography (OCT) demonstrated the presence of an aneurysm without intramural thrombus and disruption of the neointima extending into the aneurysm. Other side of stent struts were well apposed and covered by neointimal tissue proli feration (Fig. 2). This case report demonstrates that dyslipidaemia and a high thrombus burden are common risk factors for aneurysm. Moreover, it supports the mechanisms for coronary artery aneurysm which have been speculated upon by Yoshikawa et al. (J Am Coll Cardiol Intv, 2010; 3:1300–1302). OCT yields novel insights into the processes of re-endothelialisation and neointimal formation following coronary intervention. Additionally, it can be used to determine coronary abnormalities, such as coronary artery aneurysm after stent implantation.
- Published
- 2013
31. Rationale, design, and methodology of the EPIC (Epidemiology of Polypharmacy and Potential Drug-Drug Interactions in Elderly Cardiac Outpatients) study
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Eda Özlek, Edip Güvenç Çekiç, Bülent Özlek, Cem Çil, Oğuzhan Çelik, Volkan Doğan, Özcan Başaran, Veysel Ozan Tanık, Halil İbrahim Özdemir, Yunus Çelik, Caner Kaçmaz, Zeki Şimşek, Hacı Murat Güneş, Özgen Şafak, Buğra Özkan, Onur Tasar, Çağatay Önal, Lütfü Bekar, and Murat Biteker
- Subjects
cardiac outpatients ,drug-drug interactions ,elderly ,polypharmacy. ,Medicine ,Internal medicine ,RC31-1245 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: The aim of this study is to assess the prevalence of polypharmacy, inappropriate drug use, and drug-drug interactions (DDIs) in elderly patients presenting at outpatient cardiology clinics in Turkey. Methods: The EPIC (Epidemiology of Polypharmacy and Potential Drug-Drug Interactions in Elderly Cardiac Outpatients) study will be an observational, real-world, multicenter study conducted to evaluate DDIs and polypharmacy in elderly cardiac outpatients. All consecutive patients (aged ≥65 years) admitted to outpatient cardiology clinics between July 30, 2018 and July 30, 2019 who provide written, informed consent will be enrolled. A total of approximately 5000 patients are to be enrolled in this non-interventional study. All of the data will be collected at one point in time and current clinical practice will be evaluated (ClinicalTrials.gov NCT03370523). Results: Patient demographics, comorbid disease characteristics, laboratory test results, and details of medication use will be collected using self-reports and medical records. The severity of comorbid disease will be recorded and scored according to Charlson Comorbidity Index (CCI) and patients will be divided into 3 groups: mild, those with a CCI score of 1–2; moderate, those with a CCI score of 3–4; and severe, those with a CCI score of ≥5. Polypharmacy will be defined as the use of 5 or more medications at one time. DDIs will be determined using the Lexicomp Online drug interaction screening tool and potentially inappropriate medications will be defined based on the 2015 update of the Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. Severe drug interactions will be defined as those in category D or X. Conclusion: EPIC will be the first large-scale study in Turkey to evaluate polypharmacy, potentially inappropriate medications, and DDIs in elderly cardiac outpatients in a real-world clinical setting.
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- 2019
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32. Complete aortic prosthetic valve dehiscence after modified Bentall-De Bono procedure
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Onur Tasar, Arzu Kalayci, Can Yucel Karabay, and Cevat Kirma
- Subjects
Complete dehiscence ,endocarditis ,prosthetic valve ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
A 56-year-old male patient was admitted to our clinic due to persistent fever despite the use of antibiotics for 2 weeks, chest pain, and presyncope. His medical history revealed that the patient underwent modified Bentall-De Bono procedure 2 months ago due to ascending aortic aneurysm and severe aortic insufficiency. Transthoracic apical 5 chamber view showed that mobile vegetation prolapsed into the left ventricular outflow tract during ventricular diastole and that mechanical prosthetic valve was superior to the aortic annulus. Transesophageal echocardiography revealed normal aortic mechanical prosthetic valve function; however, the valve was positioned more superior to the annular plane and a dense vegetation was observed. Moreover, a complete dehiscence of the prosthetic valve was attached to aortic annulus with a single stitch in an area between noncoronary sinus and left coronary sinus. Dense thrombus formation was observed in the perivalvular region. Many cases with prosthetic valve endocarditis and partial dehiscence as its complication have been reported in the literature. However, to the best of our knowledge, there is no reported case of complete dehiscence secondary to infective endocarditis following complete ascending aortic graft and prosthetic aortic valve replacement (modified Bentall-De Bono procedure).
- Published
- 2018
- Full Text
- View/download PDF
33. A Generic Framework for Combining Multiple Segmentations in Geographic Object-Based Image Analysis
- Author
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Sébastien Lefèvre, David Sheeren, and Onur Tasar
- Subjects
GEOBIA ,segmentation fusion ,segmentation evaluation ,consensus ,remote sensing ,Geography (General) ,G1-922 - Abstract
The Geographic Object-Based Image Analysis (GEOBIA) paradigm relies strongly on the segmentation concept, i.e., partitioning of an image into regions or objects that are then further analyzed. Segmentation is a critical step, for which a wide range of methods, parameters and input data are available. To reduce the sensitivity of the GEOBIA process to the segmentation step, here we consider that a set of segmentation maps can be derived from remote sensing data. Inspired by the ensemble paradigm that combines multiple weak classifiers to build a strong one, we propose a novel framework for combining multiple segmentation maps. The combination leads to a fine-grained partition of segments (super-pixels) that is built by intersecting individual input partitions, and each segment is assigned a segmentation confidence score that relates directly to the local consensus between the different segmentation maps. Furthermore, each input segmentation can be assigned some local or global quality score based on expert assessment or automatic analysis. These scores are then taken into account when computing the confidence map that results from the combination of the segmentation processes. This means the process is less affected by incorrect segmentation inputs either at the local scale of a region, or at the global scale of a map. In contrast to related works, the proposed framework is fully generic and does not rely on specific input data to drive the combination process. We assess its relevance through experiments conducted on ISPRS 2D Semantic Labeling. Results show that the confidence map provides valuable information that can be produced when combining segmentations, and fusion at the object level is competitive w.r.t. fusion at the pixel or decision level.
- Published
- 2019
- Full Text
- View/download PDF
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