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2. Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021

Author

Farrar, Daniel S., Drouin, Olivier, Moore Hepburn, Charlotte, Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin Thibodeau, Melanie, Orkin, Julia, Ouldali, Naïm, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Proulx-Gauthier, Jean-Philippe, Purewal, Rupeena, Ricci, Christina, Sadarangani, Manish, Salvadori, Marina I., Thibeault, Roseline, Top, Karina A., Viel-Thériault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Published
2022
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5. Caracteristiques des hospitalisations au Canada d'enfants ayant contracte une infection aigue par le SRAS-CoV-2 en 2020

Author

Drouin, Olivier, Hepburn, Charlotte Moore, Farrar, Daniel S., Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin, Melanie, Luu, Thuy Mai, Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Top, Karina A., Viel-Theriault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Subjects
Infection, Health
Abstract

Contexte : Les facteurs de risque de complications graves de l'infection par le SRAS-CoV-2 n'ont pas ete bien etablis chez les enfants. Nous avons voulu decrire les hospitalisations pediatriques associees au SRAS-CoV-2 au Canada et identifier les facteurs de risque de maladie grave. Methodes : Nous avons procede a une etude prospective nationale en utilisant l'infrastructure du Programme canadien de surveillance pediatrique (PCSP). Les hospitalisations d'enfants ayant contracte une infection par le SRAS-CoV-2 confirmee en laboratoire de microbiologie ont ete rapportees du 8 avril au 31 decembre 2020 au moyen de questionnaires hebdomadaires en ligne distribues au reseau du PCSP, qui compte plus de 2800 pediatres. Nous avons categorise les hospitalisations comme suit : liees a la COVID-19, infections decouvertes fortuitement, ou hospitalisations pour des raisons sociales ou de controle des infections, et degage les facteurs de risque associes a la gravite de la maladie chez les patients hospitalises. Resultats : Sur les 264 hospitalisations d'enfants ayant contracte le SRAS-CoV-2 au cours de la periode de l'etude de 9 mois, 150 (56,8 %) ont ete associees a la COVID-19 et 100 (37,9 %o) etaient des cas decouverts fortuitement (admission pour d'autres raisons et decouverte fortuite du SRAS-CoV-2 par depistage positif). Les nourrissons (37,3 %) et les adolescents (29,6 %) representaient la majorite des cas. Parmi les hospitalisations liees a la COVID-19, 52 patients (34,7 %) etaient atteints d'une forme grave de la mala die, dont 42 (28,0 % des cas lies a la COVID-19) ont eu besoin d'une forme d'assistance respiratoire ou hemodynamique, et 59 (39,3 %o) presentaient au moins 1 comorbidite sous-jacente. Les enfants atteints d'obesite, de maladies neurologiques chroniques ou de maladies pulmonaires chroniques, a l'exclusion de l'asthme, etaient plus susceptibles de presenter une forme grave ou critique de la COVID-19. Interpretation : Parmi les enfants hospitalises au Canada chez lesquels on a diagnostique une infection par le SRAS-CoV-2 au debut de la pandemie de COVID-19, la decouverte fortuite du SRAS-CoV-2 a ete frequente. Chez les enfants hospitalises pour une COVID-19 aigue, l'obesite et les comorbidites neurologiques et respiratoires ont ete associees a une gravite accrue., En date du 31 decembre 2020, le Canada comptait 581 427 cas confirmes d'infection par le SRAS-CoV-2 (1). Comme dans d'autres pays, la plupart des infections confirmees ont ete diagnostiquees [...]

Published
2021
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6. Characteristics of children admitted to hospital with acute SARS-CoV-2 infection in Canada in 2020

Author

Drouin, Olivier, Hepburn, Charlotte Moore, Farrar, Daniel S., Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin, Melanie, Luu, Thuy Mai, Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Top, Karina A., Viel-Theriault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Subjects
Children -- Diseases, Pediatric research -- 2020 AD, Hospital patients -- Statistics -- Demographic aspects -- 2020 AD, Health
Abstract

Background: Risk factors for severe outcomes of SARS-CoV-2 infection are not well established in children. We sought to describe pediatric hospital admissions associated with SARS-CoV-2 infection in Canada and identify risk factors for more severe disease. Methods: We conducted a national prospective study using the infrastructure of the Canadian Paediatric Surveillance Program (CPSP). Cases involving children who were admitted to hospital with microbiologically confirmed SARS-CoV-2 infection were reported from Apr. 8 to Dec. 31 2020, through weekly online questionnaires distributed to the CPSP network of more than 2800 pediatricians. We categorized hospital admissions as related to COVID-19, incidental, or for social or infection control reasons and determined risk factors for disease severity in hospital. Results: Among 264 hospital admissions involving children with SARS-CoV-2 infection during the 9-month study period, 150 (56.8%) admissions were related to COVID-19 and 100 (37.9%) were incidental infections (admissions for other reasons and found to be positive for SARS-CoV-2 on screening). Infants (37.3%) and adolescents (29.6%) represented most cases. Among hospital admissions related to COVID-19, 52 (34.7%) had critical disease, 42 (28.0%) of whom required any form of respiratory or hemodynamic support, and 59 (39.3%) had at least 1 underlying comorbidity. Children with obesity, chronic neurologic conditions or chronic lung disease other than asthma were more likely to have severe or critical COVID-19. Interpretation: Among children who were admitted to hospital with SARS-CoV-2 infection in Canada during the early COVID-19 pandemic period, incidental SARS-CoV-2 infection was common. In children admitted with acute COVID-19, obesity and neurologic and respiratory comorbidities were associated with more severe disease., As of Dec. 31, 2020, Canada had 581427 confirmed cases of SARS-CoV-2 infection. (1) Similar to other countries, most confirmed infections were in adults, in part because of initial testing [...]

Published
2021
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10. Caregivers’ Experiences With a Web- and Mobile-Based Platform for Children With Medical Complexity and the Role of a Live Platform Coach: Thematic Analysis

Author

Shouldice, Ainslie Claire, primary, Beatty, Madison, additional, Adams, Sherri, additional, Dharmaraj, Blossom, additional, Moore, Clara, additional, Stinson, Jennifer Nan, additional, Desai, Arti, additional, Bartlett, Leah, additional, Culbert, Erin, additional, Cohen, Eyal, additional, and Orkin, Julia, additional

Published
2023
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11. De novo missense variants in RAC3 cause a novel neurodevelopmental syndrome

Author

Costain, Gregory, Callewaert, Bert, Gabriel, Heinz, Tan, Tiong Y., Walker, Susan, Christodoulou, John, Lazar, Tamas, Menten, Björn, Orkin, Julia, Sadedin, Simon, Snell, Meaghan, Vanlander, Arnaud, Vergult, Sarah, White, Susan M., Scherer, Stephen W., Hayeems, Robin Z., Blaser, Susan, Wodak, Shoshana J., Chitayat, David, Marshall, Christian R., and Meyn, M. Stephen

Published
2019
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12. Paediatric inflammatory multisystem syndrome in Canada: population-based surveillance and role of SARS-CoV-2 linkage

Author

El Tal, Tala, primary, Morin, Marie-Paule, additional, Morris, Shaun K., additional, Farrar, Daniel S., additional, Berard, Roberta A., additional, Kakkar, Fatima, additional, Moore Hepburn, Charlotte, additional, Baerg, Krista, additional, Beaufils, Camille, additional, Bennett, Terri-Lyn, additional, Benseler, Susanne M., additional, Beaudoin-Bussières, Guillaume, additional, Chan, Kevin, additional, Cyr, Claude, additional, Dahdah, Nagib, additional, Donner, Elizabeth J., additional, Drouin, Olivier, additional, Edjoc, Rojiemiahd, additional, Eljaouhari, Maryem, additional, Embree, Joanne E., additional, Farrell, Catherine, additional, Finzi, Andrés, additional, Forgie, Sarah, additional, Giroux, Ryan, additional, Kang, Kristopher T., additional, King, Melanie, additional, Laffin Thibodeau, Melanie, additional, Lang, Bianca, additional, Laxer, Ronald M., additional, Luu, Thuy Mai, additional, McCrindle, Brian W., additional, Orkin, Julia, additional, Papenburg, Jesse, additional, Pound, Catherine M., additional, Price, Victoria E., additional, Proulx-Gauthier, Jean-Philippe, additional, Purewal, Rupeena, additional, Sadarangani, Manish, additional, Salvadori, Marina I., additional, Thibeault, Roseline, additional, Top, Karina A., additional, Viel-Thériault, Isabelle, additional, Haddad, Elie, additional, Scuccimarri, Rosie, additional, and Yeung, Rae S. M., additional

Published
2023
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14. Secondary impacts of the COVID-19 pandemic at a tertiary children’s hospital in Canada: a mixed-methods study

Author

Diskin, Catherine, primary, Orkin, Julia, additional, Dharmaraj, Blossom, additional, Agarwal, Tanvi, additional, Parmar, Arpita, additional, McNaughton, Kelly, additional, Cohen, Eyal, additional, Sunderji, Alia, additional, Faraoni, David, additional, Fecteau, Annie, additional, Fischer, Jason, additional, Maynes, Jason, additional, Mahant, Sanjay, additional, and Friedman, Jeremy, additional

Published
2023
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15. Screening for psychosocial risk in caregivers of children with medical complexity during the COVID-19 pandemic: a cross-sectional study

Author

Pitch, Natalie, primary, Verma, Rahul, additional, Davidson, Laura, additional, Robertson, Taylor, additional, Anagnostopoulos, Gregory, additional, Sunkonkit, Kanokkarn, additional, Qazi, Adam, additional, Ambreen, Munazzah, additional, Mekhuri, Samantha, additional, Miller, Michael R, additional, Orkin, Julia, additional, and Amin, Reshma, additional

Published
2023
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26. 50 Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021

Author

Farrar, Daniel, primary, Drouin, Olivier, additional, Hepburn, Charlotte Moore, additional, Baerg, Krista, additional, Chan, Kevin, additional, Cyr, Claude, additional, Donner, Elizabeth, additional, Embree, Joanne, additional, Farrell, Catherine, additional, Forgie, Sarah, additional, Giroux, Ryan, additional, Kang, Kristopher, additional, King, Melanie, additional, Laffin-Thibodeau, Melanie, additional, Luu, Thuy-Mai, additional, Orkin, Julia, additional, Ouldali, Naïm, additional, Papenburg, Jesse, additional, Pound, Catherine, additional, Price, Victoria E, additional, Proulx-Gauthier, Jean-Phillippe, additional, Purewal, Rupeena, additional, Sadarangani, Manish, additional, Salvadori, Marina, additional, Thibeault, Roseline, additional, Top, Karina, additional, Viel-Thériault, Isabelle, additional, Kakkar, Fatima, additional, and Morris, Shaun, additional

Published
2022
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27. Pharmacogenetic profiling via genome sequencing in children with medical complexity

Author

Pan, Amy, primary, Scodellaro, Sierra, additional, Khan, Tayyaba, additional, Ushcatz, Inna, additional, Wu, Wendy, additional, Curtis, Meredith, additional, Cohen, Eyal, additional, Cohn, Ronald D., additional, Hayeems, Robin Z., additional, Meyn, M. Stephen, additional, Orkin, Julia, additional, Otal, Jaskiran, additional, Reuter, Miriam S., additional, Walker, Susan, additional, Scherer, Stephen W., additional, Marshall, Christian R., additional, Cohn, Iris, additional, and Costain, Gregory, additional

Published
2022
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36. eP205: Pharmacogenetic profiling via genome sequencing in children with medical complexity

Author

Pan, Amy, primary, Scodellaro, Sierra, additional, Khan, Tayyaba, additional, Ushcatz, Inna, additional, Wu, Wendy, additional, Curtis, Meredith, additional, Cohen, Eyal, additional, Cohn, Ronald, additional, Hayeems, Robin, additional, Meyn, M. Stephen, additional, Orkin, Julia, additional, Otal, Jaskiran, additional, Reuter, Miriam, additional, Walker, Susan, additional, Scherer, Stephen, additional, Marshall, Christian, additional, Cohn, Iris, additional, and Costain, Gregory, additional

Published
2022
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49. Process Evaluation of a Hub-and-Spoke Model to Deliver Coordinated Care for Children with Medical Complexity across Ontario: Facilitators, Barriers and Lessons Learned

Author

Lin, Jia Lu, primary, Quartarone, Samantha, additional, Aidarus, Nasra, additional, Chan, Carol, additional, Hubbert, Jackie, additional, Orkin, Julia, additional, Fayed, Nora, additional, Major, Nathalie, additional, Soscia, Joanna, additional, Lim, Audrey, additional, French, Simon, additional, Moretti, Myla, additional, and Cohen, Eyal, additional

Published
2021
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