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1. Cyclophosphamide increases the frequency of sister chromatid exchange in direct preparations of human chorionic villi in the absence of supplementary enzymatic activation systems

Author

M. Piantanida, Giuseppe Simoni, Mauro Buscaglia, and Pariani S

Subjects
Mitomycin, Sister chromatid exchange, Mutagen, Biology, medicine.disease_cause, In vivo, Pregnancy, Genetics, medicine, Humans, Cyclophosphamide, Genetics (clinical), Biotransformation, chemistry.chemical_classification, Mutagenicity Tests, Mitomycin C, Molecular biology, In vitro, Enzyme, medicine.anatomical_structure, chemistry, Biochemistry, Cell culture, embryonic structures, Chorionic villi, Female, Chorionic Villi, Sister Chromatid Exchange, Research Article, Mutagens
Abstract

A study was performed to evaluate the effect on the frequency of sister chromatid exchange in first trimester chorionic villi of two chemical compounds, mitomycin C and cyclophosphamide. Mitomycin C is generally known to induce an increase in sister chromatid exchange both in vivo and in vitro standard conditions. Cyclophosphamide is a compound requiring additional enzymatic enrichment of the culture medium to express its mutagenic activity under in vitro conditions. We exposed chorionic villi samples to these chemicals without the use of conventional cell cultures and without adding enzymatic extracts to the medium. The results indicate a statistically significant increase in the frequency of sister chromatid exchange after exposure to both compounds and also at lower dosages.

Published
1992

4. Chromosome 14 maternal uniparental disomy in the euploid cell line of a fetus with mosaic 46,XX/47,XX,+14 karyotype.

Author

Sirchia SM, De Andreis C, Pariani S, Grimoldi MG, Molinari A, Buscaglia M, and Simoni G

Subjects
Adult, Alleles, DNA analysis, Female, Humans, Karyotyping, Minisatellite Repeats genetics, Polymorphism, Genetic, Pregnancy, Chromosome Aberrations, Chromosomes, Human, Pair 14, Fetus ultrastructure, Mosaicism genetics
Abstract

We investigated the parental origin of the extra chromosome 14 and of the two chromosomes 14 of the euploid cell line, in a case of fetal mosaicism 46,XX/47,XX+14 diagnosed at amniocentesis. Molecular analysis of five polymorphic loci of the short tandem repeat type was performed. Markers D14S43 and D14S49 showed the presence of maternal uniparental disomy of chromosome 14 in the apparently normal cell line. The distribution of the markers analysed along the chromosome suggests maternal heterodisomy with a large isodisomic segment in the telomeric region, possibly caused by meiotic crossing-over.

Published
1994
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5. Does choice make a difference to contraceptive use? Evidence from east Java.

Author

Pariani S, Heer DM, and Van Arsdol MD Jr

Subjects
Contraception psychology, Decision Making, Female, Health Services Research, Humans, Indonesia, Marriage psychology, Patient Education as Topic standards, Professional-Patient Relations, Quality of Health Care, Choice Behavior, Contraception methods, Family Planning Services standards, Patient Compliance
Abstract

This study investigates sustained use of contraceptives among women in East Java, Indonesia. Interest is focused on the effect of whether the client's choice of contraceptive method was granted or denied, and the interaction between whether choice was granted or denied and husband-wife concurrence concerning method choice. Data were collected twice in a panel survey. The first round was conducted in family planning clinics among women initiating contraceptive use; the second was a follow-up household survey carried out 12 months later. Whether the user was granted her choice of method was found to be a very important determinant of sustained use of contraceptives. The interaction between whether choice was granted and whether there was husband-wife concurrence on method choice was also important. The highest rate of discontinuation occurred when method choice was denied in the presence of husband-wife agreement on method choice, and the lowest rate occurred when method choice was granted in the presence of such concurrence. The results imply that contraceptive continuation can be enhanced either when family planning workers pay more attention to the stated desires of their clients, or when policy is instituted allowing clients to use their method of choice.

Published
1991

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