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1. COSINE-100U: Upgrading the COSINE-100 Experiment for Enhanced Sensitivity to Low-Mass Dark Matter Detection

Author

Lee, D. H., Cho, J. Y., Ha, C., Jeon, E. J., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Ko, Y. J., Lee, H., Lee, H. S., Lee, I. S., Lee, J., Lee, S. H., Lee, S. M., Maruyama, R. H., Park, J. C., Park, K. S., Park, K., Park, S. D., Seo, K. M., Son, M. K., and Yu, G. H.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

An upgrade of the COSINE-100 experiment, COSINE-100U, has been prepared for installation at Yemilab, a new underground laboratory in Korea, following 6.4 years of operation at the Yangyang Underground Laboratory. The COSINE-100 experiment aimed to investigate the annual modulation signals reported by the DAMA/LIBRA but observed a null result, revealing a more than 3$\sigma$ discrepancy. COSINE-100U seeks to explore new parameter spaces for dark matter detection using NaI(Tl) detectors. All eight NaI(Tl) crystals, with a total mass of 99.1 kg, have been upgraded to improve light collection efficiency, significantly enhancing dark matter detection sensitivity. This paper describes the detector upgrades, performance improvements, and the enhanced sensitivity to low-mass dark matter detection in the COSINE-100U experiment., Comment: 14 pages, 17 figures

Published
2024

2. COSINE-100 Full Dataset Challenges the Annual Modulation Signal of DAMA/LIBRA

Author

Carlin, N., Cho, J. Y., Choi, J. J., Choi, S., Ezeribe, A. C., Franca, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Lee, Y. J., Leonard, D. S., Luan, N. T., Machado, V. H. A., Manzato, B. B., Maruyama, R. H., Neal, R. J., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, J. C., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Cavalcante, D. F. F. S., Son, M. K., Spooner, N. J. C., Truc, L. T., Yang, L., and Yu, G. H.

Subjects
High Energy Physics - Experiment
Abstract

For over 25 years, the DAMA/LIBRA collaboration has claimed to observe an annual modulation signal, suggesting the existence of dark matter interactions. However, no other experiments have replicated their result using different detector materials. To address this puzzle, the COSINE-100 collaboration conducted a model-independent test using 106 kg of sodium iodide as detectors, the same target material as DAMA/LIBRA. Analyzing data collected over 6.4 years, with improved energy calibration and time-dependent background description, we found no evidence of an annual modulation signal, challenging the DAMA/LIBRA result with a confidence level greater than 3$\sigma$. This finding represents a significant step toward resolving the long-standing debate surrounding DAMA/LIBRA's dark matter claim, indicating that the observed modulation is unlikely to be caused by dark matter interactions.

Published
2024

3. Lowering threshold of NaI(Tl) scintillator to 0.7 keV in the COSINE-100 experiment

Author

Yu, G. H., Carlin, N., Cho, J. Y., Choi, J. J., Choi, S., Ezeribe, A. C., França, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Lee, Y. J., Leonard, D. S., Luan, N. T., Machado, V. H. A., Manzato, B. B., Maruyama, R. H., Neal, R. J., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, J. C., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Cavalcante, D. F. F. S., Son, M. K., Spooner, N. J. C., Truc, L. T., and Yang, L.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

COSINE-100 is a direct dark matter search experiment, with the primary goal of testing the annual modulation signal observed by DAMA/LIBRA, using the same target material, NaI(Tl). In previous analyses, we achieved the same 1 keV energy threshold used in the DAMA/LIBRA's analysis that reported an annual modulation signal with 11.6$\sigma$ significance. In this article, we report an improved analysis that lowered the threshold to 0.7 keV, thanks to the application of Multi-Layer Perception network and a new likelihood parameter with waveforms in the frequency domain. The lower threshold would enable a better comparison of COSINE-100 with new DAMA results with a 0.75 keV threshold and account for differences in quenching factors. Furthermore the lower threshold can enhance COSINE-100's sensitivity to sub-GeV dark matter searches.

Published
2024

4. Improved background modeling for dark matter search with COSINE-100

Author

Yu, G. H., Carlin, N., Cho, J. Y., Choi, J. J., Choi, S., Ezeribe, A. C., Franca, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Lee, Y. J., Leonard, D. S., Luan, N. T., Manzato, B. B., Maruyama, R. H., Neal, R. J., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, J. C., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Cavalcante, D. F. F. S., Son, M. K., Spooner, N. J. C., Truc, L. T., and Yang, L.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

COSINE-100 aims to conclusively test the claimed dark matter annual modulation signal detected by DAMA/LIBRA collaboration. DAMA/LIBRA has released updated analysis results by lowering the energy threshold to 0.75 keV through various upgrades. They have consistently claimed to have observed the annual modulation. In COSINE-100, it is crucial to lower the energy threshold for a direct comparison with DAMA/LIBRA, which also enhances the sensitivity of the search for low-mass dark matter, enabling COSINE-100 to explore this area. Therefore, it is essential to have a precise and quantitative understanding of the background spectrum across all energy ranges. This study expands the background modeling from 0.7 to 4000 keV using 2.82 years of COSINE-100 data. The modeling has been improved to describe the background spectrum across all energy ranges accurately. Assessments of the background spectrum are presented, considering the nonproportionality of NaI(Tl) crystals at both low and high energies and the characteristic X-rays produced by the interaction of external backgrounds with materials such as copper. Additionally, constraints on the fit parameters obtained from the alpha spectrum modeling fit are integrated into this model. These improvements are detailed in the paper.

Published
2024

5. Nonproportionality of NaI(Tl) Scintillation Detector for Dark Matter Search Experiments

Author

Lee, S. M., Adhikari, G., Carlin, N., Cho, J. Y., Choi, J. J., Choi, S., Ezeribe, A. C., a, L. E. Fran., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, S. W., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, Y. J., Leonard, D. S., Luan, N. T., Manzato, B. B., Maruyama, R. H., Neal, R. J., Nikkel, J. A., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, J. C., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Cavalcante, D. F. F. S., Scarff, A., Son, M. K., Spooner, N. J. C., Truc, L. T., Yang, L., and Yu, G. H.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We present a comprehensive study of the nonproportionality of NaI(Tl) scintillation detectors within the context of dark matter search experiments. Our investigation, which integrates COSINE-100 data with supplementary $\gamma$ spectroscopy, measures light yields across diverse energy levels from full-energy $\gamma$ peaks produced by the decays of various isotopes. These $\gamma$ peaks of interest were produced by decays supported by both long and short-lived isotopes. Analyzing peaks from decays supported only by short-lived isotopes presented a unique challenge due to their limited statistics and overlapping energies, which was overcome by long-term data collection and a time-dependent analysis. A key achievement is the direct measurement of the 0.87 keV light yield, resulting from the cascade following electron capture decay of $^{22}$Na from internal contamination. This measurement, previously accessible only indirectly, deepens our understanding of NaI(Tl) scintillator behavior in the region of interest for dark matter searches. This study holds substantial implications for background modeling and the interpretation of dark matter signals in NaI(Tl) experiments., Comment: 12 pages, 7 figures

Published
2024
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6. Alpha backgrounds in NaI(Tl) crystals of COSINE-100

Author

Adhikari, G., Carlin, N., Cavalcante, D. F. F. S., Cho, J. Y., Choi, J. J., Choi, S., Ezeribe, A. C., Franca, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, S. W., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Lee, Y. J., Leonard, D. S., Luan, N. T., Manzato, B. B., Maruyama, R. H., Neal, R. J., Nikkel, J. A., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, J. C., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Scar, A., Shin, K. A., Son, M. K., Spooner, N. J. C., Truc, L. T., Yang, L., Yu, G. H., and COSINE-100, for

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

COSINE-100 is a dark matter direct detection experiment with 106 kg NaI(Tl) as the target material. 210Pb and daughter isotopes are a dominant background in the WIMP region of interest and are detected via beta decay and alpha decay. Analysis of the alpha channel complements the background model as observed in the beta/gamma channel. We present the measurement of the quenching factors and Monte Carlo simulation results and activity quantification of the alpha decay components of the COSINE-100 NaI(Tl) crystals. The data strongly indicate that the alpha decays probabilistically undergo two possible quenching factors but require further investigation. The fitted results are consistent with independent measurements and improve the overall understanding of the COSINE-100 backgrounds. Furthermore, the half-life of 216Po has been measured to be 143.4 +/- 1.2 ms, which is consistent with and more precise than recent measurements.

Published
2023
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7. Search for inelastic WIMP-iodine scattering with COSINE-100

Author

Adhikari, G., Carlin, N., Choi, J. J., Choi, S., Ezeribe, A. C., Franca, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Lee, Y. J., Leonard, S., Luan, N. T., Manzato, B. B., Maruyama, R. H., Neal, R. J., Nikkel, J. A., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Cavalcante, D. F. F. S., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., and Yu, G. H.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report the results of a search for inelastic scattering of weakly interacting massive particles (WIMPs) off $^{127}$I nuclei using NaI(Tl) crystals with a data exposure of 97.7 kg$\cdot$years from the COSINE-100 experiment. The signature of inelastic WIMP-$^{127}$I scattering is a nuclear recoil accompanied by a 57.6 keV $\gamma$-ray from the prompt deexcitation, producing a more energetic signal compared to the typical WIMP nuclear recoil signal. We found no evidence for this inelastic scattering signature and set a 90 $\%$ confidence level upper limit on the WIMP-proton spin-dependent, inelastic scattering cross section of $1.2 \times 10^{-37} {\rm cm^{2}}$ at the WIMP mass 500 ${\rm GeV/c^{2}}$., Comment: 8 pages, 5 figures. arXiv admin note: text overlap with arXiv:2104.03537

Published
2023
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8. Search for Boosted Dark Matter in COSINE-100

Author

Adhikari, G., Carlin, N., Choi, J. J., Choi, S., Ezeribe, A. C., Franca, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Lee, Y. J., Leonard, D. S., Luan, N. T., Manzato, B. B., Maruyama, R. H., Neal, R. J., Nikkel, J. A., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Cavalcante, D. F. F. S., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., and Yu, G. H.

Subjects
High Energy Physics - Experiment
Abstract

We search for energetic electron recoil signals induced by boosted dark matter (BDM) from the galactic center using the COSINE-100 array of NaI(Tl) crystal detectors at the Yangyang Underground Laboratory. The signal would be an excess of events with energies above 4 MeV over the well-understood background. Because no excess of events are observed in a 97.7 kg$\cdot$years exposure, we set limits on BDM interactions under a variety of hypotheses. Notably, we explored the dark photon parameter space, leading to competitive limits compared to direct dark photon search experiments, particularly for dark photon masses below 4\,MeV and considering the invisible decay mode. Furthermore, by comparing our results with a previous BDM search conducted by the Super-Kamionkande experiment, we found that the COSINE-100 detector has advantages in searching for low-mass dark matter. This analysis demonstrates the potential of the COSINE-100 detector to search for MeV electron recoil signals produced by the dark sector particle interactions., Comment: 7 pages, 4 figures

Published
2023
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9. Search for bosonic super-weakly interacting massive particles at COSINE-100

Author

Adhikari, G., Carlin, N., Choi, J. J., Choi, S., Ezeribe, A. C., Franca, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Lee, Y. J., Leonard, D. S., Luan, N. T., Manzato, B. B., Maruyama, R. H., Neal, R. J., Nikkel, J. A., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Cavalcante, D. F. F. S., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., and Yu, G. H.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We present results of a search for bosonic super-weakly interacting massive particles (BSW) as keV scale dark matter candidates that is based on an exposure of 97.7 kg$\cdot$year from the COSINE experiment. In this search, we employ, for the first time, Compton-like as well as absorption processes for pseudoscalar and vector BSWs. No evidence for BSWs is found in the mass range from 10 $\mathrm{keV/c}^2$ to 1 $\mathrm{MeV/c}^2$, and we present the exclusion limits on the dimensionless coupling constants to electrons $g_{ae}$ for pseudoscalar and $\kappa$ for vector BSWs at 90% confidence level. Our results show that these limits are improved by including the Compton-like process in masses of BSW, above $\mathcal{O}(100\,\mathrm{keV/c}^2)$.

Published
2023
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10. Search for solar bosonic dark matter annual modulation with COSINE-100

Author

Adhikari, G., Carlin, N., Choi, J. J., Choi, S., Ezeribe, A. C., França, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Lee, Y. J., Leonard, D. S., Luan, N. T., Manzato, B. B., Maruyama, R. H., Neal, R. J., Nikkel, J. A., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Cavalcante, D. F. F. S., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., and Yu, G. H.

Subjects
High Energy Physics - Experiment
Abstract

We present results from a search for solar bosonic dark matter using the annual modulation method with the COSINE-100 experiment. The results were interpreted considering three dark sector bosons models: solar dark photon; DFSZ and KSVZ solar axion; and Kaluza-Klein solar axion. No modulation signal that is compatible with the expected from the models was found from a data-set of 2.82 yr, using 61.3 kg of NaI(Tl) crystals. Therefore, we set a 90$\%$ confidence level upper limits for each of the three models studied. For the solar dark photon model, the most stringent mixing parameter upper limit is $1.61 \times 10^{-14}$ for dark photons with a mass of 215 eV. For the DFSZ and KSVZ solar axion, and the Kaluza-Klein axion models, the upper limits exclude axion-electron couplings, $g_{ae}$, above $1.61 \times 10^{-11}$ for axion mass below 0.2 keV; and axion-photon couplings, $g_{a\gamma\gamma}$, above $1.83 \times 10^{-11}$ GeV$^{-1}$ for an axion number density of $4.07 \times 10^{13}$ cm$^{-3}$. This is the first experimental search for solar dark photons and DFSZ and KSVZ solar axions using the annual modulation method. The lower background, higher light yield and reduced threshold of NaI(Tl) crystals of the future COSINE-200 experiment are expected to enhance the sensitivity of the analysis shown in this paper. We show the sensitivities for the three models studied, considering the same search method with COSINE-200., Comment: 13 pages, 16 figures

Published
2023
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11. An induced annual modulation signature in COSINE-100 data by DAMA/LIBRA's analysis method

Author

Adhikari, G., Carlin, N., Choi, J. J., Choi, S., Ezeribe, A. C., Franca, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Lee, Y. J., Leonard, D. S., Manzato, B. B., Maruyama, R. H., Neal, R. J., Nikkel, J. A., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., and Yu, G. H.

Subjects
High Energy Physics - Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Nuclear Experiment
Abstract

The DAMA/LIBRA collaboration has reported the observation of an annual modulation in the event rate that has been attributed to dark matter interactions over the last two decades. However, even though tremendous efforts to detect similar dark matter interactions were pursued, no definitive evidence has been observed to corroborate the DAMA/LIBRA signal. Many studies assuming various dark matter models have attempted to reconcile DAMA/LIBRA's modulation signals and null results from other experiments, however no clear conclusion can be drawn. Apart from the dark matter hypothesis, several studies have examined the possibility that the modulation is induced by variations in their detector's environment or their specific analysis methods. In particular, a recent study presents a possible cause of the annual modulation from an analysis method adopted by the DAMA/LIBRA experiment in which the observed annual modulation could be reproduced by a slowly varying time-dependent background. Here, we study the COSINE-100 data using an analysis method similar to the one adopted by the DAMA/LIBRA experiment and observe a significant annual modulation, although the modulation phase is almost opposite to that of the DAMA/LIBRA data. Assuming the same background composition for COSINE-100 and DAMA/LIBRA, simulated experiments for the DAMA/LIBRA without dark matter signals also provide significant annual modulation with an amplitude similar to DAMA/LIBRA with opposite phase. Even though this observation does not explain the DAMA/LIBRA's results directly, this interesting phenomenon motivates deeper studies of the time-dependent DAMA/LIBRA background data.

Published
2022
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12. Three-year annual modulation search with COSINE-100

Author

Collaboration, COSINE-100, Adhikari, G., de Souza, E. Barbosa, Carlin, N., Choi, J. J., Choi, S., Ezeribe, A. C., França, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kauer, M., Kim, H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Kwon, H. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Leonard, D. S., Manzato, B. B., Maruyama, R. H., Neal, R. J., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., and Yu, G. H.

Subjects
High Energy Physics - Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

COSINE-100 is a direct detection dark matter experiment that aims to test DAMA/LIBRA's claim of dark matter discovery by searching for a dark matter-induced annual modulation signal with NaI(Tl) detectors. We present new constraints on the annual modulation signal from a dataset with a 2.82 yr livetime utilizing an active mass of 61.3 kg, for a total exposure of 173 kg$\cdot$yr. This new result features an improved event selection that allows for both lowering the energy threshold to 1 keV and a more precise time-dependent background model. In the 1-6 keV and 2-6 keV energy intervals, we observe best-fit values for the modulation amplitude of 0.0067$\pm$0.0042 and 0.0051$\pm$0.0047 counts/(day$\cdot$kg$\cdot$keV), respectively, with a phase fixed at 152.5 days., Comment: 11 pages, 8 figures

Published
2021
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13. Searching for low-mass dark matter via Migdal effect in COSINE-100

Author

Adhikari, G., Carlin, N., Choi, J. J., Choi, S., Ezeribe, A. C., Franca, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kauer, M., Kim, H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Kwon, H. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Leonard, D. S., Manzato, B. B., Maruyama, R. H., Neal, R. J., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., and Yu, G. H.

Subjects
High Energy Physics - Experiment, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We report on the search for weakly interacting massive particle (WIMP) dark matter candidates in the galactic halo that interact with sodium and iodine nuclei in the COSINE-100 experiment and produce energetic electrons that accompany recoil nuclei via the the Migdal effect. The WIMP mass sensitivity of previous COSINE-100 searches that relied on the detection of ionization signals produced by target nuclei recoiling from elastic WIMP-nucleus scattering was restricted to WIMP masses above $\sim$5 GeV/$c^2$ by the detectors' 1 keVee energy-electron-equivalent threshold. The search reported here looks for recoil signals enhanced by the Migdal electrons that are ejected during the scattering process. This is particularly effective for the detection of low-mass WIMP scattering from the crystals' sodium nuclei in which a relatively larger fraction of the WIMP's energy is transferred to the nucleus recoil energy and the excitation of its orbital electrons. In this analysis, the low-mass WIMP search window of the COSINE-100 experiment is extended to WIMP mass down to 200 MeV/$c^2$. The low-mass WIMP sensitivity will be further improved by lowering the analysis threshold based on a multivariable analysis technique. We consider the influence of these improvements and recent developments in detector performance to re-evaluate sensitivities for the future COSINE-200 experiment. With a 0.2 keVee analysis threshold and high light-yield NaI(Tl) detectors (22 photoelectrons/keVee), the COSINE-200 experiment can explore low-mass WIMPs down to 20 MeV/$c^2$ and probe previously unexplored regions of parameter space., Comment: 10 pages, 8 figures

Published
2021
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15. Prognostic impact of plasma glucose on cardiogenic shock patients with or without diabetes ellitus: smart rescue trial

Author

Choi, S H, primary, Park, S D, additional, Lee, M J, additional, Ko, Y G, additional, Yu, C W, additional, Chun, W J, additional, Jang, W J, additional, Kim, H J, additional, Bae, J W, additional, Kwon, S U, additional, Kim, J S, additional, Lee, W S, additional, Jeong, J O, additional, Lim, S H, additional, and Yang, J H, additional

Published
2022
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17. Three-year annual modulation search with COSINE-100

Author

100 Collaboration, Adhikari, G., de Souza, E. Barbosa, Carlin, N., Choi, J. J., Choi, S., Ezeribe, A. C., França, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kauer, M., Kim, H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Kwon, H. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Leonard, D. S., Manzato, B. B., Maruyama, R. H., Neal, R. J., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., and Yu, G. H.

Subjects
High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), High Energy Physics - Experiment
Abstract

COSINE-100 is a direct detection dark matter experiment that aims to test DAMA/LIBRA's claim of dark matter discovery by searching for a dark matter-induced annual modulation signal with NaI(Tl) detectors. We present new constraints on the annual modulation signal from a dataset with a 2.82 yr livetime utilizing an active mass of 61.3 kg, for a total exposure of 173 kg$\cdot$yr. This new result features an improved event selection that allows for both lowering the energy threshold to 1 keV and a more precise time-dependent background model. In the 1-6 keV and 2-6 keV energy intervals, we observe best-fit values for the modulation amplitude of 0.0067$\pm$0.0042 and 0.0051$\pm$0.0047 counts/(day$\cdot$kg$\cdot$keV), respectively, with a phase fixed at 152.5 days., 11 pages, 8 figures

Published
2021

19. The impact of hiatus hernia on the radiologist

Author

Park, S. D. Scott

Subjects
616.07
Abstract

1. Hiatus hernia is a clinical entity, occurring mainly in females in the proportion of about two to one, and mainly in the middle aged or elderly. 2. There are a great variety of symptoms, likely to be confused with upper abdominal conditions and ischaemic heart disease. 3. Radiology will differentiate the former, and radiology and electrocardiography the latter. It is emphasised that in the latter, confusion will rarely arise if a careful case history is taken. 4. Because of the complex neuro muscular mechanism, drugs cannot be relied upon to prevent hernia or, more important, its common complication reflux. 5. Cine radiology at present gives no added information as to the mechanism of hiatus hernia and reflux. 6. The results of surgical repair are disappointing. 7. The operation of vagotomy does not dispose to hiatus hernia or reflux, and, incidentally, in my series proved to be an excellent operation for duodenal ulcer. 8. I suggest, in view of the last two findings that upper abdominal tone plays a part, at least equal to a tight hiatus and strong crura, in preventing hernia and reflux.

Published
1959

22. Genetic origin, admixture and population history of aurochs (Bos primigenius) and primitive European cattle

Author

Upadhyay, M R, Chen, W, Lenstra, J A, Goderie, C R J, MacHugh, D E, Park, S D E, Magee, D A, Matassino, D, Ciani, F, Megens, H-J, van Arendonk, J A M, Groenen, M A M, Marsan, P A, Balteanu, V, Dunner, S, Garcia, J F, Ginja, C, Kantanen, J, Sub Physical Oceanography, LS IRAS Tox Algemeen, Sub Veterinary Genetics, LS Ges. van de bouwkunst, dIRAS RA-1, Sub Physical Oceanography, LS IRAS Tox Algemeen, Sub Veterinary Genetics, LS Ges. van de bouwkunst, and dIRAS RA-1

Subjects
Gene Flow, 0301 basic medicine, Genetics, Genetics (clinical), Demographic history, ved/biology.organism_classification_rank.species, Population, Animal Breeding and Genomics, Breeding, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, Human population genetics, Life Science, Animals, Fokkerij en Genomica, Domestication, education, Isolation by distance, education.field_of_study, Settore AGR/17 - ZOOTECNICA GENERALE E MIGLIORAMENTO GENETICO, Models, Genetic, Fossils, ved/biology, Taurine cattle, 0402 animal and dairy science, 04 agricultural and veterinary sciences, Aurochs, Zebu, biology.organism_classification, 040201 dairy & animal science, Europe, Bos primigenius, Genetics, Population, 030104 developmental biology, Evolutionary biology, WIAS, Original Article, Cattle, Corrigendum
Abstract

The domestication of taurine cattle initiated ~10 000 years ago in the Near East from a wild aurochs (Bos primigenius) population followed by their dispersal through migration of agriculturalists to Europe. Although gene flow from wild aurochs still present at the time of this early dispersion is still debated, some of the extant primitive cattle populations are believed to possess the aurochs-like primitive features. In this study, we use genome-wide single nucleotide polymorphisms to assess relationship, admixture patterns and demographic history of an ancient aurochs sample and European cattle populations, several of which have primitive features and are suitable for extensive management. The principal component analysis, the model-based clustering and a distance-based network analysis support previous works suggesting different histories for north-western and southern European cattle. Population admixture analysis indicates a zebu gene flow in the Balkan and Italian Podolic cattle populations. Our analysis supports the previous report of gene flow between British and Irish primitive cattle populations and local aurochs. In addition, we show evidence of aurochs gene flow in the Iberian cattle populations indicating wide geographical distribution of the aurochs. Runs of homozygosity (ROH) reveal that demographic processes like genetic isolation and breed formation have contributed to genomic variations of European cattle populations. The ROH also indicate recent inbreeding in southern European cattle populations. We conclude that in addition to factors such as ancient human migrations, isolation by distance and cross-breeding, gene flow between domestic and wild-cattle populations also has shaped genomic composition of European cattle populations.Heredity advance online publication, 28 September 2016; doi:10.1038/hdy.2016.79.

Published
2016
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24. Genetic origin, admixture and population history of aurochs (Bos primigenius) and primitive European cattle

Author

Upadhyay, M R, Chen, W, Lenstra, J A, Goderie, C R J, MacHugh, D.E., Park, S D E, Magee, David A., Matassino, Donato, Ciani, F, Megens, H.J., van Arendonk, J A M, Groenen, M A M, Afd Pharmaceutics, LS IRAS Tox Algemeen, Sub Veterinary Genetics, LS Ges. van de bouwkunst, and dIRAS RA-1

Subjects
Genetics, Genetics (clinical)
Abstract

This corrects the article DOI: 10.1038/hdy.2016.79.

Published
2017

30. Genetic origin, admixture and population history of aurochs (Bos primigenius) and primitive European cattle

Author

Sub Physical Oceanography, LS IRAS Tox Algemeen, Sub Veterinary Genetics, LS Ges. van de bouwkunst, dIRAS RA-1, Upadhyay, M R, Chen, W, Lenstra, J A, Goderie, C R J, MacHugh, D E, Park, S D E, Magee, D A, Matassino, D, Ciani, F, Megens, H-J, van Arendonk, J A M, Groenen, M A M, Marsan, P A, Balteanu, V, Dunner, S, Garcia, J F, Ginja, C, Kantanen, J, Sub Physical Oceanography, LS IRAS Tox Algemeen, Sub Veterinary Genetics, LS Ges. van de bouwkunst, dIRAS RA-1, Upadhyay, M R, Chen, W, Lenstra, J A, Goderie, C R J, MacHugh, D E, Park, S D E, Magee, D A, Matassino, D, Ciani, F, Megens, H-J, van Arendonk, J A M, Groenen, M A M, Marsan, P A, Balteanu, V, Dunner, S, Garcia, J F, Ginja, C, and Kantanen, J

Published
2017

31. Genetic origin, admixture and population history of aurochs (Bos primigenius) and primitive European cattle

Author

Afd Pharmaceutics, LS IRAS Tox Algemeen, Sub Veterinary Genetics, LS Ges. van de bouwkunst, dIRAS RA-1, Upadhyay, M R, Chen, W, Lenstra, J A, Goderie, C R J, MacHugh, D.E., Park, S D E, Magee, David A., Matassino, Donato, Ciani, F, Megens, H.J., van Arendonk, J A M, Groenen, M A M, European Cattle Genetic Diversity Consortium, Afd Pharmaceutics, LS IRAS Tox Algemeen, Sub Veterinary Genetics, LS Ges. van de bouwkunst, dIRAS RA-1, Upadhyay, M R, Chen, W, Lenstra, J A, Goderie, C R J, MacHugh, D.E., Park, S D E, Magee, David A., Matassino, Donato, Ciani, F, Megens, H.J., van Arendonk, J A M, Groenen, M A M, and European Cattle Genetic Diversity Consortium

Published
2017

32. Genetic origin, admixture and population history of aurochs (Bos primigenius) and primitive European cattle

Author

Upadhyay, M. R., Chen, W., Lenstra, J. A., Goderie, C. R. J., Machugh, D. E., Park, S. D. E., Magee, D. A., Matassino, D., Ciani, F., Megens, H. J., Van Arendonk, J. A. M., Groenen, M. A. M., Ajmone Marsan, Paolo, Balteanu, V., Dunner, S., Garcia, J. F., Ginja, C., Kantanen, J., Ajmone Marsan, Paolo (ORCID:0000-0003-3165-4579), Upadhyay, M. R., Chen, W., Lenstra, J. A., Goderie, C. R. J., Machugh, D. E., Park, S. D. E., Magee, D. A., Matassino, D., Ciani, F., Megens, H. J., Van Arendonk, J. A. M., Groenen, M. A. M., Ajmone Marsan, Paolo, Balteanu, V., Dunner, S., Garcia, J. F., Ginja, C., Kantanen, J., and Ajmone Marsan, Paolo (ORCID:0000-0003-3165-4579)

Abstract

The domestication of taurine cattle initiated ∼10 000 years ago in the Near East from a wild aurochs (Bos primigenius) population followed by their dispersal through migration of agriculturalists to Europe. Although gene flow from wild aurochs still present at the time of this early dispersion is still debated, some of the extant primitive cattle populations are believed to possess the aurochs-like primitive features. In this study, we use genome-wide single nucleotide polymorphisms to assess relationship, admixture patterns and demographic history of an ancient aurochs sample and European cattle populations, several of which have primitive features and are suitable for extensive management. The principal component analysis, the model-based clustering and a distance-based network analysis support previous works suggesting different histories for north-western and southern European cattle. Population admixture analysis indicates a zebu gene flow in the Balkan and Italian Podolic cattle populations. Our analysis supports the previous report of gene flow between British and Irish primitive cattle populations and local aurochs. In addition, we show evidence of aurochs gene flow in the Iberian cattle populations indicating wide geographical distribution of the aurochs. Runs of homozygosity (ROH) reveal that demographic processes like genetic isolation and breed formation have contributed to genomic variations of European cattle populations. The ROH also indicate recent inbreeding in southern European cattle populations. We conclude that in addition to factors such as ancient human migrations, isolation by distance and cross-breeding, gene flow between domestic and wild-cattle populations also has shaped genomic composition of European cattle populations.

Published
2017

36. Dual antiplatelet therapy duration after coronary stenting in clinical practice: Results of an EAPCI survey

Author

Valgimigli, M., Costa, F., Byrne, R., Haude, M., Baumbach, A., Windecker, S., Aaroe, J., Aasa, M., Abdel-Salam, A. M., Alaarag, A. F., Accardi, R., Adel, A., Alcazar De La Torre, E., Alejos, R., Alfonso Jimenez, V., Alhashimi, H. M. M., Aljeboury, A., Almeida De Sousa, J., Almusawi, A., Alshaikha, M., Altaf, S., Altahmody, K. E. A., Alvarez Contreras, L. R., Amarasena, N., Amoroso, G., Anderson, R., Ando, G., Andrade, J., Andreou, A. Y., Angulo, J., Antonio, T., Aprigliano, G., Aquilina, M., Arafa, S. E. O., Aramberry, L., Arampatzis, C. A., Araujo, J. J., Asher, E., Ates, I., Athanasias, D., Auer, J., Auffret, V., Ayala, F. J., Baba, C., Baglioni, P., Bagur, R., Balam-Ortiz, E., Balducelli, M., Bam Pas, G., Barbash, I. M., Barbosa, A. H. P., Barbosa, R., Barnay, P., Barroso, L., Basti, A., Bax, M., Bayet, G., Beijk, M. A., Beltran, R., Berenguer Jofresa, A., Berroth, R., Berti, S., Berumen Dominguez, L. E., Bhasin, A., Bhaya, M., Bianco, M., Biasco, L., Bikicki, M., Bonarjee, V. V. S., Bonechi, F., Borges Santos, M., Boshev, M., Bouferrouk, A., Bounartzidi, M., Bousoula, E., Brie, D., Brtko, M., Brugaletta, S., Brull, D. J., Buchter, B., Buendia, R., Burzotta, Francesco, Butz, T., Buzzetti, F., Bychowiec, B., Cadeddu, M., Campanile, A., Carneiro, J. G., Carrilho-Ferreira, P., Carrillo Guevara, J. E., Carter, A. J., Casal-Heredia, H., Castiglioni, B., Castro Fabiano, L., Cavalcante Silva, R., Cavalcanti De Oliveira, D., Cavalcanti, R. C., Cavazza, C., Centemero, M. P., Chabane, H. K., Chamie, D., Chatzis, D., Chaves, A. J., Cheng, S., Chinchilla, H., Ciabatti, N., Cirillo, P., Citaku, H., Claeys, M. J., Clifford, C., Coceani, M., Coggiola, J., Cohen, D. J., Conway, D. S. G., Cornelis, K., Coroleu, S. F., Corral, J. M., Cortese, B., Coskun, U., Costa, R. A., Coste, P., Coufal, Z., Cox, S., Cozma, A., Crean, P., Crenshaw, M. H., Cristian, U., Cruz-Alvarado, J. E., Cuculi, F., Cuenza, L., Cyrne Carvalho, H., D'Ascenzo, F., D'Urbano, M., Damonte, A., Dan Florin, F., Dana, A., Dangoisse, V., De Backer, O., De Cock, D., De Vita, M., Debski, A., Delgado, A., Devadathan, S., Dhamrait, S., Di Lorenzo, E., Di Serafino, D., Diego-Nieto, A., Dievart, F., Diez, J. L., Dimitriadis, K., Dina, C., Doerner, O., Donahue, M., Donis, J., Drieghe, B., Drissi, M. F., Du Fretay, H., Dziewierz, A., Echavarria-Pinto, M., Echeverria Romero, R. G., Economou, F., Eftychiou, C., Egdell, R., El Hosieny, A., El Meguid, K., Elabbassi, W., Elesgerli, S., Elghetany, H., Elizondo, J. C., Elkahlout, A., Elrowiny, R., Elserafy, A. S., Emam, A., Emara, A., Emmanouil, P., Ercilla, J., Erglis, A., Eslam Taha, E., Esmaeil, S., Esposito, G., Ettori, F., Eugenio, N., Everaert, B., Ezquerra Aguilar, W., Falu, R., Farag, E., Farjalla, J., Feldman, L., Feldman, M., Felice, H., Fernandez-Nofrerias, E., Fernandez-Rodriguez, D., Ferranti, F., Ferreira, Q., Ferrone, M., Fleischmann, C., Flessas, D., Formigli, D., Fozilov, H., Fraccaro, C., Freitas, J. O., Fresco, C., Fridrich, V., Furmaniuk, J., Gagnor, A., Galasso, G., Galeazzi, G. L., Galli, S., Galvez Villacorta, V., Gandolfo, C., Garcia, E., Garcia-Blas, S., Garducci, S., Garg, S., Garro, N., Gatto, L., Georgiou, M. G., Ghanem, I., Ghose, T., Giacchi, G., Giang, P. T., Giesler, T., Giovino, M., Girardi, P., Girasis, C., Giunio, L., Giustino, G., Glatthor, C., Glogar, H. D., Golledge, P., Gomez Moreno, J., Gomez Recio, M., Gommeaux, A., Grantalis, G., Greco, F., Grundeken, M. J., Grunert, S., Gudmundsdottir, I., Guenoun, M., Guerios, E., Gupta, R., Gupta, S., Gutierrez, C., Hafeez, I., Halvorsen, S., Hamed Hussein, G. A., Hammoudeh, A., Hansen, P. R., Harb, S., Hawas, J. M., Hayrapetyan, H., Heintzen, M. P., Hengstenberg, C., Herity, N., Hernandez, F., Heyse, A., Hicham, D., Hildick-Smith, D., Hill, J., Hillani, A., Hiltrop, N., Hiramori, A., Hobson, A. R., Homan, D. J., Hooda, A., Ielasi, A., Ierna, S., Iftikhar, A. K., Ilic, I., Imai, Y., Imperadore, F., Indolfi, C., Iorga, V., Ipek, E., Ito, S., Jacksch, R., Jae-Sik, J., James, S., Jamshidi, P., Jerbi, J., Jimenez Quevedo, P., Jimenez-Navarro, M., Jimenez-Santos, M., Jin, Q. H., Joksas, V., Jovic, D., Junejo, S., Kallel, R., Kamal, A., Kamiya, H., Kannan, D., Kantaria, M., Kapetanopoulos, A., Kara Ali, B., Karjalainen, P. P., Karthikeyan, V. J., Kato, R., Katsikis, A., Kefer, J., Keta, D., Ketteler, T., Khan, M., Kharlamov, A., Kinani, A., Kinani, T., Kinnaird, T., Kislo, A., Kiviniemi, T., Kleiban, A., Kluck, B., Kocayigit, I., Kokis, A., Komiyama, N., Konstantinos, L., Kordalis, A., Kozak, M., Krecki, R., Kristensen, S. D., Krizanic, F., Krsticevic, L., Kuex, H., Kukreja, N., Kulic, M., Kulikovskikh, Y. V., Kulkarni, P., Kumar, N., Kumar Soni, A., Kuzmenko, E., L'Allier, P. L., Langner, O., Lapin, O., Lauer, B., Leclercq, F., Leibundgut, G., Leon Aliz, E., Leon, C., Leon, K., Leoncini, M., Leone, A. M., Leroux, L., Lesiak, M., Letilovic, T., Lev, E., Linares Vicente, J. A., Lindsay, S., Loh, P. H., Loncar, G., Loo, B., Lopez, M. B., Lopez-Cuellar, J., Lozano, I., Luigia, P., Lunde, K., Lyczywek, M., Macdougall, D., Mafrici, A., Magni, V., Magro, M., Mainar, V., Makarovic, Z., Malik, N., Maly, M., Mansour, S., Marenco, R. E., Maresta, A., Marinho, G. E., Marino, R. L., Marinucci, L., Martins, H. C., Martins, J., Mashayekhi, K., Masood, A., Maurer, E., Mavrogianni, A. D., Mazurek, T., Medina, A., Mehilli, J., Mellwig, K. P., Mendez, M., Mendiz, O. A., Meneses, A., Mercado, L. A., Mereuta, A., Mezzapelle, G., Milanovic, N., Mohamed, S. M., Mohanad, A., Mohanty, A., Moorthy, N., Morales, F. J., More, R., Moreno Samos, J. C., Moreno-Martinez, F. L., Moscato, F., Mossmann, M., Mrevlje, B., Muller-Eichelberg, A., Musumeci, G., Nadir Khan, M., Najim, S., Nakamura, S., Nakao, F., Naveri, H., Negus, B., Nerla, R., Nguyen, H. T., Niess, G. S., Nikas, D. N., Niroomand, F., Niva, J., Nogueira, J. W., Nombela-Franco, L., Notrica, M., Nouri, B., Nugue, O., Nunes, G. L., Ober, M., Ochoa, J., Oh, J. H., Ojeda, S., Oktay Tureli, H., Olowe, Y., Oluseun, A., Opolski, G., Ornelas, C. E., Otasevic, P., Ozturk, A., Padilla, F., Pagny, J. Y., Paolantonio, D., Papaioannou, G. I., Parodi, G., Patil, S. N., Pavei, A., Pavia, A., Pavlidis, A., Pell, A., Percoco, G. F., Pernasetti, L. V., Pescoller, F., Petropoulakis, P., Piatti, L., Picardi, E., Pieroni, D. M., Pina, J., Pinheiro, L. F., Pinto, F. J., Pipa, J. L., Piroth, Z., Pisano, F., Podbregar, M., Polak, G., Polimeni, A., Postadzhiyan, A., Postu, M., Poulimenos, L. E., Pow Chon Long, F., Poyet, R., Pradhan, A., Predescu, L. M., Prida, X. E., Saad, A., Prog, R., Pulikal, D. G. A., Qiangzhong, P. I., Radu, M. D., Rajendran, D., Ram Anil Raj, M. R., Ramazzotti, V., Rapacciuolo, A., Ratib, K., Raungaard, B., Raviola, E., Reppas, E., Reyes, J. A., Rezek, M., Riess, G. J., Rifaie, O., Rigattieri, S., Rissanen, T., Ristic, A. D., Rittger, H., Roberts, J., Rodriguez Saavedra, A., Roik, M., Roshan Rao, K., Routledge, H., Rubboli, A., Rudolph, T., Rudzitis, A., Ruiters, A., Ruiz Ros, J. A., Ruiz-Garcia, J., Ruiz-Nodar, J. M., Sabate, M., Sabnis, G., Sabouret, P., Sacra, C., Saghatelyan, M., Sahin, M., Said, S., Salachas, A. J., Salas Llamas, J. P., Salih, A., Sanchez, O. D., Sanchez-Gila, J., Sanchez-Perez, I., Santarelli, A., Sardovski, Sarenac, D., Sarma, J., Sarno, G., Savonitto, S., Sayied Abdullah, A., Schafer, A., Scherillo, M., Schneider, H., Schuhlen, H., Sciahbasi, A., Seca, L., Sedlon, P., Semenka, J., Serra, L. A., Sesana, M., Sethi, A., Sgueglia, G. A., Shaheen, S., Shahri, H., Sheiban, I., Shyu, K. G., Silva, C. E. F., Sionis, D., Siqueira, D. A., Siqueira, M. J., Smits, P., Sobhy, M., Sokolov, M., Soliman, S., Somani, A. N., Sridhar, G., Stakos, D., Stasek, J., Stefanini, G., Steigen, T. K., Stewart, Stipal, R., Stochino, M. L., Stoel, M. G., Subla, R. M., Suliman, A., Summaria, F., Stoyanov, N., Syed, A. A., Tanaka, Y., Tashani, A., Tauzin, S., Tawade, N., Tawfik, M., Tayeh, O., Terzic, I., Testa, L., Thevan, B., Thiam, M., Tiecco, F., Tierala, I., Tilea, I., Tilsted, H. H., Tomasik, A. R., Tonev, I., Torres Bosco, A., Tousek, P., Townend, J., Tran Ngoc, T., Triantafyllou, K., Tsigkas, G., Tsioufis, C., Turri, M., Tyligadis, G., Ugo, F., Ultramari, F. T., Urban, P., Uren, N., Uretsky, B. F., Uribe, C. E., Usman, B., Valadez Molina, F., Van Houwelingen, K. G., Vandormael, M., Varvarovsky, I., Vassilis, V., Velasquez, D., Verdoia, M., Vermeersch, P., Vidal-Perez, R., Vinesh, J., Violini, R., Vista, J. H., Vogt, F., Vogt, M., Vokac, D., Vom Dahl, J., Vranckx, P., Wahab, A., Wang, R., Wang, T. D., Wani, S., Weisz, S. H., Werner, G. S., Wilkinson, J. R., Wolf, A., Youssef, A., Yumoto, K., Zaderenko, N., Zaghloul Darwish, A. M., Zahn, R., Zaro, T., Zavalloni, D., Zbinden, R., Zekanovic, D., Zhang, B., Zhang, C., Zhang, Y. J., Zhonghan, N., Zingarelli, A., Zueco, J., Zuhairy, H., Abbate, A., Abdel Hamid, M., Abdelmegid, M. A. F., Acuna-Valerio, J., Adriaenssens, T., Agostoni, P., Aikot, H., Alameda, M., Alcaraz, H., Almendro-Delia, M., Altug Cakmak, H., Amir, A., Arjomand, A., Assomull, R., Atalar, E., Avramides, D., Aytek Simsek, M., Aznaouridis, K., Azpeitia, Y., Barnabas, C., Barsness, G. W., Bartorelli, A. L., Basoglu, A., Benezet, J., Benincasa, S., Berland, J., Berrocal, D. H., Bett, N., Boskovic, S., Brandao, V., Caporale, R., Caprotta, F., Carrabba, N., Cazaux, P., Cheniti, G., Chinchilla Calix, H., Chung, W. Y., Cicco, N. A., Cieza, T., Clapp, B., Commeau, P., Cuellar, C., De Benedictis, M., De La Torre Hernandez, J. M., De Vroey, F., Degertekin, M., Eberli, F. R., Eggebrecht, H., Ekicibasi, E., Elmaraghi, M., Elod, P., Ergene, A. O., Fadlalla, V. F., Farah, M. A., Fernandez Vina, R., Ferro, A., Fischer, D., Flore, V., Foley, D. P., Gafoor, S., Gallo, S., Gaspardone, A., Gavrilescu, D., Gentiletti, A., Gilard, M., Giovannelli, F., Gonzalez Pacheco, I., Gonzalo, N., Grajek, S., Gurgel De Medeiros, J. P., Haine, S., Hakim, D., Hakim Vista, J. J., Hallani, H., Hamid, M., Helft, G., Heppell, R. M., Hernandez-Enriquez, M., Hlinomaz, O., Ho Choo, E., Huqi, A., Hurtado, E. O., Iakovou, I., Iosseliani, D., Janssens, L., Jean, M., Jensen, J. K., Jesudason, P., Jimenez Diaz, V. A., Karchevsky, D., Karpovskii, A., Katsimagklis, G., Kereiakes, D., Kersanova, N. C., Kesavan, S., Khaled, H., Khalil, S. A., Kiatchoosakun, S., Kim, K. S., Kirma, C., Koltowski, L., Konteva, M., Kozinski, L., Kuehn, C. R., Kumar, S., Kyriakakis, C. G., Laanmets, P., Labrunie, A., Ladwiniec, A., Lai, G., Laine, M., Latib, A., Lattuca, B., Lazarevic, A. M., Lee, K. S., Legrand, V., Leiva, G., Lester, N., Levchyshyna, O., Livia, G., Londero, H. F., Luha, O., Lupi, A., Lupkovics, G., Maaliki, S., Maeng, M., Mahr, N. C., Mantyla, P., Mariano, E., Marsit, N., Mcdonough, T. J., Medda, M., Mejia Viana, S., Merigo Azpir, C. A., Mitreski, S., Moreno, R., Moreu, J., Muehler, M., Muir, D., Munoz Molina, R., Musilli, N., Myc, J., Nadra, I., Nagy, C. D., Narayanan, A., Neugebauer, P., Nguyen, M., Nick, H., Nicolino, A., Obradovic, S. D., Paizis, I., Panagiotis, P., Park, S. D., Park, S. J., Pasquetto, G., Patel, D., Paunovic, D., Pedon, L., Pereira Machado, F., Pershukov, H., Petrou, E., Pinton, F. A., Preti, G., Puri, R., Pyxaras, S. A., Quintanilla, J., Rhouati, A., Ribeiro De Oliveira, I., Rivetti, L., Rodriguez, A. E., Rotevatn, S., Rubartelli, P., Sachdeva, R., Sanchez-Perez, H., Sangiorgi, G., Santoro, G. M., Saporito, F., Scappaticci, M., Schmermund, A., Schmidt, J. E., Schmitz, T., Schneider, T. I., Schuchlenz, H., Sepulveda Varela, P., Shaw, E., Silva Marques, J., Skalidis, E., Slhessarenko, J., Spaulding, C., Stankovic, G., Suwannasom, P., Synetos, A., Szuster, E., Taha, S., Tavano, D., Tebet, M., Thury, A., Toutouzas, K., Triantafyllis, A. S., Tsikaderis, D., Tumscitz, C., Tzanogiorgis, I., Udovichenko, A., Ulrike, N., Unikas, R., Valerio, M. G., Van Mieghem, C., Vandendriessche, T., Vavlukis, M., Vigna, C., Vilar, J. V., Vizzari, G., Voudris, V., Wafa, S., Wagner, D. R., Wichter, T., Wiedemann, S., Williams, P. D., Woody, W., Yding, A., Zachow, G., Webster, M., Burzotta F. (ORCID:0000-0002-6569-9401), Valgimigli, M., Costa, F., Byrne, R., Haude, M., Baumbach, A., Windecker, S., Aaroe, J., Aasa, M., Abdel-Salam, A. M., Alaarag, A. F., Accardi, R., Adel, A., Alcazar De La Torre, E., Alejos, R., Alfonso Jimenez, V., Alhashimi, H. M. M., Aljeboury, A., Almeida De Sousa, J., Almusawi, A., Alshaikha, M., Altaf, S., Altahmody, K. E. A., Alvarez Contreras, L. R., Amarasena, N., Amoroso, G., Anderson, R., Ando, G., Andrade, J., Andreou, A. Y., Angulo, J., Antonio, T., Aprigliano, G., Aquilina, M., Arafa, S. E. O., Aramberry, L., Arampatzis, C. A., Araujo, J. J., Asher, E., Ates, I., Athanasias, D., Auer, J., Auffret, V., Ayala, F. J., Baba, C., Baglioni, P., Bagur, R., Balam-Ortiz, E., Balducelli, M., Bam Pas, G., Barbash, I. M., Barbosa, A. H. P., Barbosa, R., Barnay, P., Barroso, L., Basti, A., Bax, M., Bayet, G., Beijk, M. A., Beltran, R., Berenguer Jofresa, A., Berroth, R., Berti, S., Berumen Dominguez, L. E., Bhasin, A., Bhaya, M., Bianco, M., Biasco, L., Bikicki, M., Bonarjee, V. V. S., Bonechi, F., Borges Santos, M., Boshev, M., Bouferrouk, A., Bounartzidi, M., Bousoula, E., Brie, D., Brtko, M., Brugaletta, S., Brull, D. J., Buchter, B., Buendia, R., Burzotta, Francesco, Butz, T., Buzzetti, F., Bychowiec, B., Cadeddu, M., Campanile, A., Carneiro, J. G., Carrilho-Ferreira, P., Carrillo Guevara, J. E., Carter, A. J., Casal-Heredia, H., Castiglioni, B., Castro Fabiano, L., Cavalcante Silva, R., Cavalcanti De Oliveira, D., Cavalcanti, R. C., Cavazza, C., Centemero, M. P., Chabane, H. K., Chamie, D., Chatzis, D., Chaves, A. J., Cheng, S., Chinchilla, H., Ciabatti, N., Cirillo, P., Citaku, H., Claeys, M. J., Clifford, C., Coceani, M., Coggiola, J., Cohen, D. J., Conway, D. S. G., Cornelis, K., Coroleu, S. F., Corral, J. M., Cortese, B., Coskun, U., Costa, R. A., Coste, P., Coufal, Z., Cox, S., Cozma, A., Crean, P., Crenshaw, M. H., Cristian, U., Cruz-Alvarado, J. E., Cuculi, F., Cuenza, L., Cyrne Carvalho, H., D'Ascenzo, F., D'Urbano, M., Damonte, A., Dan Florin, F., Dana, A., Dangoisse, V., De Backer, O., De Cock, D., De Vita, M., Debski, A., Delgado, A., Devadathan, S., Dhamrait, S., Di Lorenzo, E., Di Serafino, D., Diego-Nieto, A., Dievart, F., Diez, J. L., Dimitriadis, K., Dina, C., Doerner, O., Donahue, M., Donis, J., Drieghe, B., Drissi, M. F., Du Fretay, H., Dziewierz, A., Echavarria-Pinto, M., Echeverria Romero, R. G., Economou, F., Eftychiou, C., Egdell, R., El Hosieny, A., El Meguid, K., Elabbassi, W., Elesgerli, S., Elghetany, H., Elizondo, J. C., Elkahlout, A., Elrowiny, R., Elserafy, A. S., Emam, A., Emara, A., Emmanouil, P., Ercilla, J., Erglis, A., Eslam Taha, E., Esmaeil, S., Esposito, G., Ettori, F., Eugenio, N., Everaert, B., Ezquerra Aguilar, W., Falu, R., Farag, E., Farjalla, J., Feldman, L., Feldman, M., Felice, H., Fernandez-Nofrerias, E., Fernandez-Rodriguez, D., Ferranti, F., Ferreira, Q., Ferrone, M., Fleischmann, C., Flessas, D., Formigli, D., Fozilov, H., Fraccaro, C., Freitas, J. O., Fresco, C., Fridrich, V., Furmaniuk, J., Gagnor, A., Galasso, G., Galeazzi, G. L., Galli, S., Galvez Villacorta, V., Gandolfo, C., Garcia, E., Garcia-Blas, S., Garducci, S., Garg, S., Garro, N., Gatto, L., Georgiou, M. G., Ghanem, I., Ghose, T., Giacchi, G., Giang, P. T., Giesler, T., Giovino, M., Girardi, P., Girasis, C., Giunio, L., Giustino, G., Glatthor, C., Glogar, H. D., Golledge, P., Gomez Moreno, J., Gomez Recio, M., Gommeaux, A., Grantalis, G., Greco, F., Grundeken, M. J., Grunert, S., Gudmundsdottir, I., Guenoun, M., Guerios, E., Gupta, R., Gupta, S., Gutierrez, C., Hafeez, I., Halvorsen, S., Hamed Hussein, G. A., Hammoudeh, A., Hansen, P. R., Harb, S., Hawas, J. M., Hayrapetyan, H., Heintzen, M. P., Hengstenberg, C., Herity, N., Hernandez, F., Heyse, A., Hicham, D., Hildick-Smith, D., Hill, J., Hillani, A., Hiltrop, N., Hiramori, A., Hobson, A. R., Homan, D. J., Hooda, A., Ielasi, A., Ierna, S., Iftikhar, A. K., Ilic, I., Imai, Y., Imperadore, F., Indolfi, C., Iorga, V., Ipek, E., Ito, S., Jacksch, R., Jae-Sik, J., James, S., Jamshidi, P., Jerbi, J., Jimenez Quevedo, P., Jimenez-Navarro, M., Jimenez-Santos, M., Jin, Q. H., Joksas, V., Jovic, D., Junejo, S., Kallel, R., Kamal, A., Kamiya, H., Kannan, D., Kantaria, M., Kapetanopoulos, A., Kara Ali, B., Karjalainen, P. P., Karthikeyan, V. J., Kato, R., Katsikis, A., Kefer, J., Keta, D., Ketteler, T., Khan, M., Kharlamov, A., Kinani, A., Kinani, T., Kinnaird, T., Kislo, A., Kiviniemi, T., Kleiban, A., Kluck, B., Kocayigit, I., Kokis, A., Komiyama, N., Konstantinos, L., Kordalis, A., Kozak, M., Krecki, R., Kristensen, S. D., Krizanic, F., Krsticevic, L., Kuex, H., Kukreja, N., Kulic, M., Kulikovskikh, Y. V., Kulkarni, P., Kumar, N., Kumar Soni, A., Kuzmenko, E., L'Allier, P. L., Langner, O., Lapin, O., Lauer, B., Leclercq, F., Leibundgut, G., Leon Aliz, E., Leon, C., Leon, K., Leoncini, M., Leone, A. M., Leroux, L., Lesiak, M., Letilovic, T., Lev, E., Linares Vicente, J. A., Lindsay, S., Loh, P. H., Loncar, G., Loo, B., Lopez, M. B., Lopez-Cuellar, J., Lozano, I., Luigia, P., Lunde, K., Lyczywek, M., Macdougall, D., Mafrici, A., Magni, V., Magro, M., Mainar, V., Makarovic, Z., Malik, N., Maly, M., Mansour, S., Marenco, R. E., Maresta, A., Marinho, G. E., Marino, R. L., Marinucci, L., Martins, H. C., Martins, J., Mashayekhi, K., Masood, A., Maurer, E., Mavrogianni, A. D., Mazurek, T., Medina, A., Mehilli, J., Mellwig, K. P., Mendez, M., Mendiz, O. A., Meneses, A., Mercado, L. A., Mereuta, A., Mezzapelle, G., Milanovic, N., Mohamed, S. M., Mohanad, A., Mohanty, A., Moorthy, N., Morales, F. J., More, R., Moreno Samos, J. C., Moreno-Martinez, F. L., Moscato, F., Mossmann, M., Mrevlje, B., Muller-Eichelberg, A., Musumeci, G., Nadir Khan, M., Najim, S., Nakamura, S., Nakao, F., Naveri, H., Negus, B., Nerla, R., Nguyen, H. T., Niess, G. S., Nikas, D. N., Niroomand, F., Niva, J., Nogueira, J. W., Nombela-Franco, L., Notrica, M., Nouri, B., Nugue, O., Nunes, G. L., Ober, M., Ochoa, J., Oh, J. H., Ojeda, S., Oktay Tureli, H., Olowe, Y., Oluseun, A., Opolski, G., Ornelas, C. E., Otasevic, P., Ozturk, A., Padilla, F., Pagny, J. Y., Paolantonio, D., Papaioannou, G. I., Parodi, G., Patil, S. N., Pavei, A., Pavia, A., Pavlidis, A., Pell, A., Percoco, G. F., Pernasetti, L. V., Pescoller, F., Petropoulakis, P., Piatti, L., Picardi, E., Pieroni, D. M., Pina, J., Pinheiro, L. F., Pinto, F. J., Pipa, J. L., Piroth, Z., Pisano, F., Podbregar, M., Polak, G., Polimeni, A., Postadzhiyan, A., Postu, M., Poulimenos, L. E., Pow Chon Long, F., Poyet, R., Pradhan, A., Predescu, L. M., Prida, X. E., Saad, A., Prog, R., Pulikal, D. G. A., Qiangzhong, P. I., Radu, M. D., Rajendran, D., Ram Anil Raj, M. R., Ramazzotti, V., Rapacciuolo, A., Ratib, K., Raungaard, B., Raviola, E., Reppas, E., Reyes, J. A., Rezek, M., Riess, G. J., Rifaie, O., Rigattieri, S., Rissanen, T., Ristic, A. D., Rittger, H., Roberts, J., Rodriguez Saavedra, A., Roik, M., Roshan Rao, K., Routledge, H., Rubboli, A., Rudolph, T., Rudzitis, A., Ruiters, A., Ruiz Ros, J. A., Ruiz-Garcia, J., Ruiz-Nodar, J. M., Sabate, M., Sabnis, G., Sabouret, P., Sacra, C., Saghatelyan, M., Sahin, M., Said, S., Salachas, A. J., Salas Llamas, J. P., Salih, A., Sanchez, O. D., Sanchez-Gila, J., Sanchez-Perez, I., Santarelli, A., Sardovski, Sarenac, D., Sarma, J., Sarno, G., Savonitto, S., Sayied Abdullah, A., Schafer, A., Scherillo, M., Schneider, H., Schuhlen, H., Sciahbasi, A., Seca, L., Sedlon, P., Semenka, J., Serra, L. A., Sesana, M., Sethi, A., Sgueglia, G. A., Shaheen, S., Shahri, H., Sheiban, I., Shyu, K. G., Silva, C. E. F., Sionis, D., Siqueira, D. A., Siqueira, M. J., Smits, P., Sobhy, M., Sokolov, M., Soliman, S., Somani, A. N., Sridhar, G., Stakos, D., Stasek, J., Stefanini, G., Steigen, T. K., Stewart, Stipal, R., Stochino, M. L., Stoel, M. G., Subla, R. M., Suliman, A., Summaria, F., Stoyanov, N., Syed, A. A., Tanaka, Y., Tashani, A., Tauzin, S., Tawade, N., Tawfik, M., Tayeh, O., Terzic, I., Testa, L., Thevan, B., Thiam, M., Tiecco, F., Tierala, I., Tilea, I., Tilsted, H. H., Tomasik, A. R., Tonev, I., Torres Bosco, A., Tousek, P., Townend, J., Tran Ngoc, T., Triantafyllou, K., Tsigkas, G., Tsioufis, C., Turri, M., Tyligadis, G., Ugo, F., Ultramari, F. T., Urban, P., Uren, N., Uretsky, B. F., Uribe, C. E., Usman, B., Valadez Molina, F., Van Houwelingen, K. G., Vandormael, M., Varvarovsky, I., Vassilis, V., Velasquez, D., Verdoia, M., Vermeersch, P., Vidal-Perez, R., Vinesh, J., Violini, R., Vista, J. H., Vogt, F., Vogt, M., Vokac, D., Vom Dahl, J., Vranckx, P., Wahab, A., Wang, R., Wang, T. D., Wani, S., Weisz, S. H., Werner, G. S., Wilkinson, J. R., Wolf, A., Youssef, A., Yumoto, K., Zaderenko, N., Zaghloul Darwish, A. M., Zahn, R., Zaro, T., Zavalloni, D., Zbinden, R., Zekanovic, D., Zhang, B., Zhang, C., Zhang, Y. J., Zhonghan, N., Zingarelli, A., Zueco, J., Zuhairy, H., Abbate, A., Abdel Hamid, M., Abdelmegid, M. A. F., Acuna-Valerio, J., Adriaenssens, T., Agostoni, P., Aikot, H., Alameda, M., Alcaraz, H., Almendro-Delia, M., Altug Cakmak, H., Amir, A., Arjomand, A., Assomull, R., Atalar, E., Avramides, D., Aytek Simsek, M., Aznaouridis, K., Azpeitia, Y., Barnabas, C., Barsness, G. W., Bartorelli, A. L., Basoglu, A., Benezet, J., Benincasa, S., Berland, J., Berrocal, D. H., Bett, N., Boskovic, S., Brandao, V., Caporale, R., Caprotta, F., Carrabba, N., Cazaux, P., Cheniti, G., Chinchilla Calix, H., Chung, W. Y., Cicco, N. A., Cieza, T., Clapp, B., Commeau, P., Cuellar, C., De Benedictis, M., De La Torre Hernandez, J. M., De Vroey, F., Degertekin, M., Eberli, F. R., Eggebrecht, H., Ekicibasi, E., Elmaraghi, M., Elod, P., Ergene, A. O., Fadlalla, V. F., Farah, M. A., Fernandez Vina, R., Ferro, A., Fischer, D., Flore, V., Foley, D. P., Gafoor, S., Gallo, S., Gaspardone, A., Gavrilescu, D., Gentiletti, A., Gilard, M., Giovannelli, F., Gonzalez Pacheco, I., Gonzalo, N., Grajek, S., Gurgel De Medeiros, J. P., Haine, S., Hakim, D., Hakim Vista, J. J., Hallani, H., Hamid, M., Helft, G., Heppell, R. M., Hernandez-Enriquez, M., Hlinomaz, O., Ho Choo, E., Huqi, A., Hurtado, E. O., Iakovou, I., Iosseliani, D., Janssens, L., Jean, M., Jensen, J. K., Jesudason, P., Jimenez Diaz, V. A., Karchevsky, D., Karpovskii, A., Katsimagklis, G., Kereiakes, D., Kersanova, N. C., Kesavan, S., Khaled, H., Khalil, S. A., Kiatchoosakun, S., Kim, K. S., Kirma, C., Koltowski, L., Konteva, M., Kozinski, L., Kuehn, C. R., Kumar, S., Kyriakakis, C. G., Laanmets, P., Labrunie, A., Ladwiniec, A., Lai, G., Laine, M., Latib, A., Lattuca, B., Lazarevic, A. M., Lee, K. S., Legrand, V., Leiva, G., Lester, N., Levchyshyna, O., Livia, G., Londero, H. F., Luha, O., Lupi, A., Lupkovics, G., Maaliki, S., Maeng, M., Mahr, N. C., Mantyla, P., Mariano, E., Marsit, N., Mcdonough, T. J., Medda, M., Mejia Viana, S., Merigo Azpir, C. A., Mitreski, S., Moreno, R., Moreu, J., Muehler, M., Muir, D., Munoz Molina, R., Musilli, N., Myc, J., Nadra, I., Nagy, C. D., Narayanan, A., Neugebauer, P., Nguyen, M., Nick, H., Nicolino, A., Obradovic, S. D., Paizis, I., Panagiotis, P., Park, S. D., Park, S. J., Pasquetto, G., Patel, D., Paunovic, D., Pedon, L., Pereira Machado, F., Pershukov, H., Petrou, E., Pinton, F. A., Preti, G., Puri, R., Pyxaras, S. A., Quintanilla, J., Rhouati, A., Ribeiro De Oliveira, I., Rivetti, L., Rodriguez, A. E., Rotevatn, S., Rubartelli, P., Sachdeva, R., Sanchez-Perez, H., Sangiorgi, G., Santoro, G. M., Saporito, F., Scappaticci, M., Schmermund, A., Schmidt, J. E., Schmitz, T., Schneider, T. I., Schuchlenz, H., Sepulveda Varela, P., Shaw, E., Silva Marques, J., Skalidis, E., Slhessarenko, J., Spaulding, C., Stankovic, G., Suwannasom, P., Synetos, A., Szuster, E., Taha, S., Tavano, D., Tebet, M., Thury, A., Toutouzas, K., Triantafyllis, A. S., Tsikaderis, D., Tumscitz, C., Tzanogiorgis, I., Udovichenko, A., Ulrike, N., Unikas, R., Valerio, M. G., Van Mieghem, C., Vandendriessche, T., Vavlukis, M., Vigna, C., Vilar, J. V., Vizzari, G., Voudris, V., Wafa, S., Wagner, D. R., Wichter, T., Wiedemann, S., Williams, P. D., Woody, W., Yding, A., Zachow, G., Webster, M., and Burzotta F. (ORCID:0000-0002-6569-9401)

Abstract

Aims: Our aim was to report on a survey initiated by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) concerning opinion on the evidence relating to dual antiplatelet therapy (DAPT) duration after coronary stenting. Methods and results: Results from three randomised clinical trials were scheduled to be presented at the American Heart Association Scientific Sessions 2014 (AHA 2014). A web-based survey was distributed to all individuals registered in the EuroIntervention mailing list (n=15,200) both before and after AHA 2014. A total of 1,134 physicians responded to the first (i.e., before AHA 2014) and 542 to the second (i.e., after AHA 2014) survey. The majority of respondents interpreted trial results consistent with a substantial equipoise regarding the benefits and risks of an extended versus a standard DAPT strategy. Two respondents out of ten believed extended DAPT should be implemented in selected patients. After AHA 2014, 46.1% of participants expressed uncertainty about the available evidence on DAPT duration, and 40.0% the need for clinical guidance. Conclusions: This EAPCI survey highlights considerable uncertainty within the medical community with regard to the optimal duration of DAPT after coronary stenting in the light of recent reported trial results. Updated recommendations for practising physicians to guide treatment decisions in routine clinical practice should be provided by international societies.

Published
2015

38. Poster Session 3

Author

Fabbri, G. M. T., primary, Baldasseroni, S., additional, Panuccio, D., additional, Zoni Berisso, M., additional, Scherillo, M., additional, Lucci, D., additional, Di Pasquale, G., additional, Mathieu, G., additional, Burazor, I., additional, Burazor, M., additional, Perisic, Z., additional, Atanaskovic, V., additional, Erakovic, V., additional, Stojkovic, A., additional, Vogtmann, T., additional, Schoebel, C., additional, Sogorski, S., additional, Sebert, M., additional, Schaarschmidt, J., additional, Fietze, I., additional, Baumann, G., additional, Penzel, T., additional, Mornos, C., additional, Ionac, A., additional, Cozma, D., additional, Dragulescu, D., additional, Mornos, A., additional, Petrescu, L., additional, Pescariu, L., additional, Brembilla-Perrot, B., additional, Khachab, H., additional, Lamberti, F., additional, Bellini, C., additional, Remoli, R., additional, Cogliandro, T., additional, Nardo, R., additional, Bellusci, F., additional, Mazzuca, V., additional, Gaspardone, A., additional, Aguinaga Arrascue, L. E., additional, Bravo, A., additional, Garcia Freire, P., additional, Gallardo, P., additional, Hasbani, E., additional, Quintana, R., additional, Dantur, J., additional, Inoue, K., additional, Ueoka, A., additional, Tsubakimoto, Y., additional, Sakatani, T., additional, Matsuo, A., additional, Fujita, H., additional, Kitamura, M., additional, Wegrzynowska, M., additional, Konduracka, E., additional, Pietrucha, A. Z., additional, Mroczek-Czernecka, D., additional, Paradowski, A., additional, Bzukala, I., additional, Nessler, J., additional, Igawa, O., additional, Adachi, M., additional, Atarashi, H., additional, Kusama, Y., additional, Kodani, E., additional, Okazaki, R., additional, Nakagomi, A., additional, Endoh, Y., additional, Baez-Escudero, J. L., additional, Dave, A. S., additional, Sasaridis, C. M., additional, Valderrabano, M., additional, Tilz, R., additional, Bai, R., additional, Di Biase, L., additional, Gallinghouse, G. 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L., additional, Merino Llorens, J. L., additional, Kaitani, K., additional, Hanazawa, K., additional, Izumi, C., additional, Nakagawa, Y., additional, Yamanaka, I., additional, Hirahara, T., additional, Sugawara, Y., additional, Suga, C., additional, Ako, J., additional, Momomura, S., additional, Galizio, N., additional, Gonzalez, J., additional, Robles, F., additional, Palazzo, A., additional, Favaloro, L., additional, Diez, M., additional, Guevara, E., additional, Fernandez, A., additional, Greenberg, S., additional, Epstein, A., additional, Goldman, D. S., additional, Sangli, C., additional, Keeney, J. A., additional, Lee, K., additional, Piers, S. R. D., additional, Van Rees, J. B., additional, Thijssen, J., additional, Borleffs, C. J. W., additional, Van Der Velde, E. T., additional, Leclercq, C. H., additional, Hero, M., additional, Mizobuchi, M., additional, Enjoji, Y., additional, Yazaki, Y., additional, Shibata, K., additional, Funatsu, A., additional, Kobayashi, T., additional, Nakamura, S., additional, Amit, G., additional, Pertzov, B., additional, Zahger, D., additional, Medesani, L., additional, Rana, R., additional, Albano, F., additional, Fraguas, H., additional, Pedersen, S. S., additional, Hoogwegt, M. T., additional, Theuns, D. A. M. J., additional, Van Den Broek, K. C., additional, Tekle, F. B., additional, Habibovic, M., additional, Alings, M., additional, Van Der Voort, P., additional, Denollet, J., additional, Vrazic, H., additional, Jilek, C., additional, Lesevic, H., additional, Tzeis, S., additional, Semmler, V., additional, Gold, M. R., additional, Burke, M. C., additional, Bardy, G. H., additional, Varma, N., additional, Pavri, B., additional, Stambler, B., additional, Michalski, J., additional, Investigators, T. R. U. S. 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X., additional, Mutch, E., additional, Brashaw-Smith, J., additional, Ball, L., additional, Leyva, F., additional, Kim, D. H., additional, Lee, M. J., additional, Lee, W. S., additional, Park, S. D., additional, Shin, S. H., additional, Woo, S. I., additional, Kwan, J., additional, Park, K. S., additional, Munetsugu, Y., additional, Tanno, K., additional, Kikuchi, M., additional, Ito, H., additional, Miyoshi, F., additional, Kawamura, M., additional, Kobayashi, Y., additional, Man, S., additional, Algra, A. M., additional, Schreurs, C. A., additional, Van Der Wall, E. E., additional, Cannegieter, S. C., additional, Swenne, C. A., additional, Iitsuka, K., additional, Kondo, T., additional, Goebbert, K., additional, Karossiene, Z., additional, Goldman, D., additional, Kallen, B., additional, Kerpi, E., additional, Sardo, J., additional, Arsenos, P., additional, Gatzoulis, K., additional, Manis, G., additional, Dilaveris, P., additional, Tsiachris, D., additional, Mytas, D., additional, Asimakopoulos, S., additional, Stefanadis, C., additional, Sideris, S., additional, Kartsagoulis, E., additional, Barbosa, O., additional, Marocolo Junior, M., additional, Silva Cortes, R., additional, Moraes Brandolis, R. A., additional, Oliveira, L. F., additional, Pertili Rodrigues De Resende, L. A., additional, Vieira Da Silva, M. A., additional, Dias Da Silva, V. J., additional, Hegazy, R. A., additional, Sharaf, I. A., additional, Fadel, F., additional, Bazaraa, H., additional, Esam, R., additional, Deshko, M. S., additional, Snezhitsky, V. A., additional, Stempen, T. P., additional, Kuroki, K., additional, Igawa, M., additional, Kuga, K., additional, Ferreira Santos, L., additional, Dionisio, T., additional, Nunes, L., additional, Machado, J., additional, Castedo, S., additional, Henriques, C., additional, Matos, A., additional, Oliveira Santos, J., additional, Kraaier, K., additional, Olimulder, M. A. G. M., additional, Galjee, M. A., additional, Van Dessel, P. F. H. M., additional, Van Der Palen, J., additional, Wilde, A. A. M., additional, Scholten, M. F., additional, Chouchou, F., additional, Poupard, L., additional, Philippe, C., additional, Court-Fortune, I., additional, Barthelemy, J.- C., additional, Roche, F., additional, Dolgoshey, T. S., additional, Madekina, G. 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G., additional, Franceschi, F., additional, Prevot, S., additional, Koutbi, L., additional, Ricard, P., additional, Saoudi, N., additional, Nazari, N., additional, Alizadeh, A., additional, Sayah, S., additional, Hekmat, M., additional, Assadian, M., additional, Ahmadzadeh, A., additional, Wnuk, M., additional, Jedrzejczyk-Spaho, J., additional, Kruszelnicka, O., additional, Piwowarska, W., additional, Fedorowski, A., additional, Burri, P., additional, Juul-Moller, S., additional, Melander, O., additional, Mitro, P., additional, Murin, P., additional, Kirsch, P., additional, Habalova, V., additional, Slaba, E., additional, Matyasova, E., additional, Barlow, M. A., additional, Blake, R. J., additional, Rostoff, P., additional, Wojewodka Zak, E., additional, Froidevaux, L., additional, Sarasin, F. P., additional, Louis-Simonet, M., additional, Hugli, O., additional, Yersin, B., additional, Schlaepfer, J., additional, Mischler, C., additional, Pruvot, E., additional, Occhetta, E., additional, Frascarelli, F., additional, Burali, A., additional, and Dovellini, E., additional

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2011
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39. Poster Session 2

Author

Andersson, T., primary, Magnusson, A., additional, Bryngelsson, I.- L., additional, Frobert, O., additional, Henriksson, K. M., additional, Edvardsson, N., additional, Poci, D., additional, Polovina, M., additional, Potpara, T., additional, Licina, M., additional, Mujovic, N., additional, Kocijancic, A., additional, Simic, D., additional, Ostojic, M. C., additional, Providencia, R. A., additional, Botelho, A., additional, Trigo, J., additional, Nascimento, J., additional, Quintal, N., additional, Mota, P., additional, Leitao-Marques, A. M., additional, Bosch, R. F., additional, Kirch, W., additional, Rosin, L., additional, Willich, S. N., additional, Pittrow, D., additional, Bonnemeier, H., additional, Valenza, M. C., additional, Martin, L., additional, Munoz Casaubon, T., additional, Valenza, G., additional, Botella, M., additional, Serrano, M., additional, Valenza, B., additional, Cabrera, I., additional, Anderson, K., additional, Benzaquen, B. S., additional, Koziolova, N., additional, Nikonova, J., additional, Shilova, Y., additional, Scherr, D., additional, Narayan, S., additional, Wright, M., additional, Krummen, D., additional, Jadidi, A., additional, Jais, P., additional, Haissaguerre, M., additional, Hocini, M., additional, Hunter, R., additional, Liu, Y., additional, Lu, Y., additional, Wang, W., additional, Schilling, R. J., additional, Bernstein, S., additional, Wong, B., additional, Rooke, R., additional, Vasquez, C., additional, Shah, R., additional, Rosenberg, S., additional, Chinitz, L., additional, Morley, G., additional, Bashir Choudhary, M., additional, Holmqvist, F., additional, Carlson, J., additional, Nilsson, H.- J., additional, Platonov, P. G., additional, Jadidi, A. S., additional, Cochet, H., additional, Miyazaki, S., additional, Shah, A. J., additional, Marrouche, N., additional, Calvo, N., additional, Nadal, M., additional, Andreu, D., additional, Tamborero, D., additional, Diaz, F. E., additional, Berruezo, A., additional, Brugada, J., additional, Mont, L., additional, Fichtner, S., additional, Hessling, G., additional, Estner, H. L., additional, Jilek, C., additional, Reents, T., additional, Ammar, S., additional, Wu, J., additional, Deisenhofer, I., additional, Nakanishi, H., additional, Kashiwase, K., additional, Hirata, A., additional, Wada, M., additional, Ueda, Y., additional, Skoda, J., additional, Neuzil, P., additional, Popelova, J., additional, Petru, J., additional, Sediva, L., additional, Reddy, V. Y., additional, Uldry, L., additional, Forclaz, A., additional, Virag, N., additional, Vesin, J.- M., additional, Kappenberger, L., additional, Sehra, R., additional, Briggs, C., additional, Rappel, W.- J., additional, Janotka, M., additional, Chovanec, M., additional, Yamashiro, K., additional, Takami, K., additional, Sakamoto, Y., additional, Satoh, K., additional, Suzuki, T., additional, Nakagawa, H., additional, Romanov, A., additional, Pokushalov, E., additional, Artemenko, S., additional, Shabanov, V., additional, Stenin, I., additional, Elesin, D., additional, Turov, A., additional, Yakubov, A., additional, Hioki, M., additional, Matsuo, S., additional, Ito, K., additional, Narui, R., additional, Yamashita, S., additional, Sugimoto, K., additional, Yoshimura, M., additional, Yamane, T., additional, Di Biase, L., additional, Gallinghouse, J. D., additional, Rajappan, K., additional, Kautzner, J., additional, Dello Russo, A., additional, Tondo, C., additional, Lorgat, F., additional, Natale, A., additional, Balta, O., additional, Buenz, K., additional, Paessler, M., additional, Anders, H., additional, Horlitz, M., additional, Deneke, T., additional, Lickfett, L., additional, Liberman, I., additional, Linhart, M., additional, Andrie, R., additional, Mittmann-Braun, E., additional, Stockigt, F., additional, Nickenig, G., additional, Schrickel, J., additional, Tilz, R., additional, Rillig, A., additional, Feige, B., additional, Metzner, A., additional, Fuernkranz, A., additional, Burchard, A., additional, Wissner, E., additional, Ouyang, F., additional, Betts, T. R., additional, Jones, M. A., additional, Wong, K. C. K., additional, Qureshi, N., additional, Bashir, Y., additional, Corbucci, G., additional, Losik, D., additional, Selina, V., additional, Crandall, M. A., additional, Daniels, C., additional, Daoud, E., additional, Kalbfleisch, S., additional, Yamaji, H., additional, Murakami, T., additional, Kawamura, H., additional, Murakami, M., additional, Hina, K., additional, Kusachi, S., additional, Dakos, G., additional, Vassilikos, V., additional, Paraskevaidis, S., additional, Mantziari, A., additional, Theophylogiannakos, S., additional, Chouvarda, I., additional, Chatzizisis, I., additional, Styliadis, I., additional, Kimura, T., additional, Fukumoto, K., additional, Nishiyama, N., additional, Aizawa, Y., additional, Fukuda, Y., additional, Sato, T., additional, Miyoshi, S., additional, Takatsuki, S., additional, Navarrete Casas, A. J., additional, Ali, I., additional, Conte, F. C., additional, Moran, M., additional, Graham, B. G., additional, Kalejs, O., additional, Lacis, R., additional, Stradins, P., additional, Koris, A., additional, Putnins, I., additional, Vikmane, M., additional, Lejnieks, A., additional, Erglis, A., additional, Estrada, A., additional, Perez Silva, A., additional, Castrejon, S., additional, Doiny, D., additional, Merino, J. L., additional, Baranchuk, A., additional, Greiss, I., additional, Simpson, C. S., additional, Abdollah, H., additional, Redfearn, D. P., additional, Buys-Topart, M., additional, Nitzsche, R., additional, Thibault, B., additional, Kathan, S., additional, Kolb, C., additional, Reif, S., additional, Schade, S., additional, Taggeselle, J., additional, Frey, A., additional, Birkenhagen, A., additional, Kohler, S., additional, Schmidt, M., additional, Cano Perez, O., additional, Buendia, F., additional, Igual, B., additional, Osca, J. M., additional, Sanchez, J. M., additional, Sancho-Tello, M. J., additional, Olague, J. M., additional, Salvador, A., additional, Tolosana, J. M., additional, Fernandez-Armenta, J., additional, Matas, M., additional, Barbarin, M. C., additional, Habibovic, M., additional, Van Den Broek, K. C., additional, Theuns, D. A. M. J., additional, Jordaens, L., additional, Alings, M., additional, Van Der Voort, P. H., additional, Pedersen, S. S., additional, Pupita, G., additional, Molini, S., additional, Brambatti, M., additional, Capucci, A., additional, Molodykh, S., additional, Idov, E. M., additional, Belyaev, O. V., additional, Segreti, L., additional, Soldati, E., additional, Zucchelli, G., additional, Di Cori, A., additional, Viani, S., additional, Paperini, L., additional, De Lucia, R., additional, Bongiorni, M. G., additional, Binner, L., additional, Taborsky, M., additional, Bello, D., additional, Heuer, H., additional, Ramza, B., additional, Jenniskens, I., additional, Johnson, W. B., additional, Silvetti, M. S., additional, Rava', L., additional, Russo, M. S., additional, Di Mambro, C., additional, Ammirati, A., additional, Gimigliano, G., additional, Prosperi, M., additional, Drago, F., additional, Santos, A. R., additional, Picarra, B., additional, Semedo, P., additional, Dionisio, P., additional, Matos, R., additional, Leitao, M., additional, Jacinto, A., additional, Trinca, M., additional, Mazzone, P., additional, Ciconte, G., additional, Marzi, A., additional, Paglino, G., additional, Vergara, P., additional, Sora, N., additional, Gulletta, S., additional, Della Bella, P., additional, Koppitz, P., additional, Fach, A., additional, Hobbiesiefken, S., additional, Fiehn, E., additional, Hambrecht, R., additional, Sperzel, J., additional, Jung, M., additional, Schmitt, J., additional, Pajitnev, D., additional, Burger, H., additional, Goebel, G., additional, Ehrlich, W., additional, Walther, T., additional, Ziegelhoeffer, T., additional, Vancura, V., additional, Wichterle, D., additional, Melenovsky, V., additional, Glikson, M., additional, Goldenberg, G., additional, Segev, A., additional, Dvir, D., additional, Kuzniec, J., additional, Finkelstein, A., additional, Hay, I., additional, Guetta, V., additional, Choo, W. K., additional, Gupta, S., additional, Kirkfeldt, R., additional, Johansen, J., additional, Nohr, E., additional, Moller, M., additional, Arnsbo, P., additional, Nielsen, J., additional, Banha, M., additional, Stojanov, P., additional, Raspopovic, S., additional, Vasic, D., additional, Savic, D., additional, Nikcevic, G., additional, Jovanovic, V., additional, Defaye, P., additional, Mondesert, B., additional, Mbaye, A., additional, Cassagneau, R., additional, Gagniere, V., additional, Jacon, J., additional, Sanfins, V., additional, Reis, H. R., additional, Nobre, J. N., additional, Martins, V. M., additional, Duarte, L. D., additional, Morais, C. M., additional, Conceicao, J. C., additional, Hero, M., additional, Rey, J. L., additional, Ducharme, A., additional, Simpson, C., additional, Stuglin, C., additional, Blier, L., additional, Senaratne, M., additional, Khaykin, Y., additional, Pinter, A., additional, Mlynarska, A., additional, Mlynarski, R., additional, Sosnowski, M., additional, Wilczek, J., additional, Iorgulescu, C., additional, Bogdan, S., additional, Constantinescu, D., additional, Caldararu, C., additional, Dorobantu, M., additional, Radu, A., additional, Vatasescu, R.- G., additional, Yusu, S., additional, Ikeda, T., additional, Mera, H., additional, Miwa, Y., additional, Abe, A., additional, Miyakoshi, M., additional, Tsukada, T., additional, Yoshino, H., additional, Nayar, V., additional, Cantelon, P., additional, Rawling, A., additional, Belham, M. R. D., additional, Pugh, P. J., additional, Osca Asensi, J., additional, Cano, O., additional, Tejada, D., additional, Munoz, B., additional, Rodriguez, M., additional, Olague, J., additional, Wecke, L., additional, Van Hunnik, A., additional, Thompson, T., additional, Di Carlo, L., additional, Zdeblick, M., additional, Auricchio, A., additional, Prinzen, F., additional, Doltra Magarolas, A., additional, Bijnens, B., additional, Silva, E., additional, Penela, D., additional, Sitges, M., additional, Ofman, P., additional, Navaravong, L., additional, Leng, J., additional, Peralta, A., additional, Hoffmeister, P., additional, Levine, R., additional, Cook, J., additional, Stoenescu, M., additional, Tettamanti, M. E., additional, Revilla Orodea, A., additional, Lopez Diaz, J., additional, De La Fuente Galan, L., additional, Arnold, R., additional, Garcia Moran, E., additional, San Roman Calvar, J. A., additional, Gomez Salvador, I., additional, Nakamura, K., additional, Takami, M., additional, Keida, T., additional, Mesato, A., additional, Higa, S., additional, Shimabukuro, M., additional, Masuzaki, H., additional, Proietti, R., additional, Sagone, A., additional, Domenichini, G., additional, Burri, H., additional, Valzania, C., additional, Biffi, M., additional, Sunthorn, H., additional, Gavaruzzi, G., additional, Foulkes, H., additional, Boriani, G., additional, Koh, S., additional, Hou, W., additional, Snell, J., additional, Poore, J., additional, Dalal, N., additional, Bornzin, G., additional, Kloppe, A., additional, Mijic, D., additional, Bogossian, H., additional, Ninios, I., additional, Zarse, M., additional, Lemke, B., additional, Guedon-Moreau, L., additional, Kouakam, C., additional, Klug, D., additional, Marquie, C., additional, Ziglio, F., additional, Kacet, S., additional, Mohamed Fereig Hamed, H., additional, Hamdy, A. M. A. L., additional, Abd El Aziz, A. H. M. E. D., additional, Nabih, M. R. V. A. T., additional, Hamdy, R. E. H. A. B., additional, Yaminisaharif, A., additional, Davoudi, G. H., additional, Kasemisaeid, A., additional, Sadeghian, S., additional, Vasheghani Farahani, A., additional, Yazdanifard, P., additional, Shafiee, A., additional, Alonso, C., additional, Grimard, C., additional, Jauvert, G., additional, Lazarus, A., additional, Mont, L. L., additional, Ortiz-Perez, J., additional, Caralt, T., additional, Escudero, J., additional, Perez, F., additional, Griffith, K. M., additional, Ferreyra, R., additional, Urena, P., additional, Demas, M., additional, Muratore, C., additional, Mazzetti, H., additional, Guardado, J., additional, Fernandes, M., additional, Pereira, V. H., additional, Canario-Almeida, F., additional, Ferreira, F., additional, Rodrigues, B., additional, Almeida, J., additional, Sokal, A., additional, Jedrzejczyk, E., additional, Lenarczyk, R., additional, Pluta, S., additional, Kowalski, O., additional, Pruszkowska, P., additional, Swiatkowski, A., additional, Kalarus, Z., additional, Heinke, M., additional, Ismer, B., additional, Kuehnert, H., additional, Heinke, T., additional, Surber, R., additional, Osypka, N., additional, Prochnau, D., additional, Figulla, H. R., additional, Iacopino, S., additional, Landolina, M., additional, Proclemer, A., additional, Padeletti, L., additional, Calvi, V., additional, Pierantozzi, A., additional, Di Stefano, P., additional, Bauer, A., additional, Bode, F., additional, Le Gal, F., additional, Deharo, J. C., additional, Delay, M., additional, Clementy, J., additional, Kawamura, M., additional, Munetsugu, Y., additional, Tanno, K., additional, Kobayashi, Y., additional, Cannom, D., additional, Hosoda, J., additional, Ishikawa, T., additional, Andoh, K., additional, Nobuyoshi, M., additional, Fujii, S., additional, Shizuta, S., additional, Isshiki, T., additional, Castel, M. A., additional, Perez-Villa, F., additional, Vidal, B., additional, Pruszkowska-Skrzep, P., additional, Szulik, M., additional, Kukulski, T., additional, Gianfranchi, L., additional, Bettiol, K., additional, Pacchioni, F., additional, Alboni, P., additional, Abu Sham'a, R., additional, Buber, J., additional, Nof, E., additional, Kuperstein, R., additional, Feinberg, M., additional, Luria, D., additional, Eldar, M., additional, Parks, K., additional, Stone, J. R., additional, Singh, J. P., additional, Hatzinikolaou-Kotsakou, E., additional, Kotsakou, M., additional, Beleveslis, T. H., additional, Moschos, G., additional, Reppas, E., additional, Latsios, P., additional, Tsakiridis, K., additional, Kazemisaeid, A., additional, Davoodi, G., additional, Yamini Sharif, A., additional, Sheikhvatan, M., additional, Toniolo, M., additional, Zanotto, G., additional, Rossi, A., additional, Tomasi, L., additional, Vassanelli, C., additional, Versteeg, H., additional, Mommersteeg, P. M. C., additional, Vergara, G., additional, Blauer, J., additional, Ranjan, R., additional, Vijayakumar, S., additional, Kholmovski, E., additional, Volland, N., additional, Macleod, R., additional, Aguinaga Arrascue, L. E., additional, Bravo, A., additional, Garcia Freire, P., additional, Gallardo, P., additional, Hasbani, E., additional, Dantur, J., additional, Quintana, R., additional, Adragao, P. P., additional, Cavaco, D., additional, Parreira, L., additional, Reis Santos, K., additional, Carmo, P., additional, Miranda, R., additional, Marcelino, S., additional, Cabrita, D., additional, Sommer, P., additional, Gaspar, T., additional, Rolf, S., additional, Arya, A., additional, Piorkowski, C., additional, Hindricks, G., additional, Valles Gras, E., additional, Bazan, V., additional, Portillo, L., additional, Suarez, F., additional, Bruguera, J., additional, Marti, J., additional, Huo, Y., additional, Richter, S., additional, Schoenbauer, R., additional, Rivas, N., additional, Casaldaliga, J., additional, Roca, I., additional, Dos, L., additional, Perez-Rodon, J., additional, Pijuan, A., additional, Garcia-Dorado, D., additional, Moya, A., additional, Carter, H. B., additional, Garg, A., additional, Hegrenes, J., additional, Sih, H. J., additional, Teplitsky, L. R., additional, Kuroki, K., additional, Tada, H., additional, Seo, Y., additional, Ishizu, T., additional, Igawa, M., additional, Sekiguchi, Y., additional, Kuga, K., additional, Aonuma, K., additional, Rodriguez A, C., additional, Mejias, J., additional, Hidalgo, P., additional, Hidalgo L, J. A., additional, Orczykowski, M., additional, Derejko, P., additional, Walczak, F., additional, Szufladowicz, E., additional, Urbanek, P., additional, Bodalski, R., additional, Bieganowska, K., additional, Szumowski, L., additional, Peichl, P., additional, Cihak, R., additional, Skalsky, I., additional, Kubus, P., additional, Vit, P., additional, Zaoral, L., additional, Gebauer, R. A., additional, Fiala, M., additional, Janousek, J., additional, Hiroshima, K., additional, Goya, M., additional, Ohe, M., additional, Hayashi, K., additional, Makihara, Y., additional, Nagashima, M., additional, An, Y., additional, Schloesser, M., additional, Lawrenz, T., additional, Meyer Zu Vilsendorf, D., additional, Strunk-Mueller, C., additional, Stellbrink, C., additional, Papagiannis, J., additional, Avramidis, D., additional, Kokkinakis, C., additional, Kirvassilis, G., additional, Eidelman, G., additional, Arenal, A., additional, Datino, T., additional, Atienza, F., additional, Gonzalez Torrecilla, E., additional, Miracle, A., additional, Hernandez, J., additional, Fernandez Aviles, F., additional, Ene, E., additional, Insulander, P., additional, Bastani, H., additional, Braunschweig, F., additional, Drca, N., additional, Kenneback, G., additional, Schwieler, J., additional, Tapanainen, J., additional, Jensen-Urstad, M., additional, Andrea, B., additional, Andrea, E. M. A., additional, Maciel, W. M., additional, Siqueira, L. S., additional, Cosenza, R. C., additional, Mittidieri, F. M., additional, Farah, S. F., additional, Atie, J. A., additional, Kanoupakis, E., additional, Kallergis, E., additional, Mavrakis, H., additional, Goudis, C., additional, Saloustros, I., additional, Malliaraki, N., additional, Chlouverakis, G., additional, Vardas, P., additional, Bonnes, J. L., additional, Jaspers Focks, J., additional, Westra, S. W., additional, Brouwer, M. A., additional, Smeets, J. L. R. M., additional, Inama, G., additional, Pedrinazzi, C., additional, Oliva, F., additional, Senni, M., additional, Zoni Berisso, M., additional, Mostov, S., additional, Haim, M., additional, Nevzorov, R., additional, Hasadi, D., additional, Starsberg, B., additional, Porter, A., additional, Kuschyk, J., additional, Schoene, A., additional, Streitner, F., additional, Veltmann, C. G., additional, Schimpf, R., additional, Borggrefe, M., additional, Luesebrink, U., additional, Gardiwal, A., additional, Oswald, H., additional, Koenig, T., additional, Duncker, D., additional, Klein, G., additional, Bastiaenen, R., additional, Batchvarov, V., additional, Atty, O., additional, Cheng, J. H., additional, Behr, E. R., additional, Gallagher, M. M., additional, Starrenburg, A. H., additional, Kraaier, K., additional, Scholten, M. F., additional, Van Der Palen, J., additional, Adhya, S., additional, Smith, L. A., additional, Zhao, T., additional, Bannister, C., additional, Kamdar, R. H., additional, Martinelli, M., additional, Siqueira, S., additional, Greco, R., additional, Nishioka, S. A. D., additional, Pedrosa, A. A. A., additional, Alkmim-Teixeira, R., additional, Peixoto, G. L., additional, Costa, R., additional, Nielsen, J. C., additional, Mortensen, P. T., additional, Johansen, J. B., additional, Kwasniewski, W., additional, Filipecki, A., additional, Urbanczyk-Swic, D., additional, Orszulak, W., additional, Trusz - Gluza, M., additional, Jimenez-Candil, J., additional, Morinigo, J., additional, Ledesma, C., additional, Martin-Luengo, C., additional, Vogtmann, T., additional, Gomer, M., additional, Stiller, S., additional, Kuehlkamp, V., additional, Zach, G., additional, Loescher, S., additional, Kespohl, S., additional, Baumann, G., additional, Snell, J. D., additional, Korsun, N., additional, Snell, J. R., additional, Morley, B., additional, Bharmi, R., additional, Nabutovsky, Y., additional, Mollerus, M., additional, Naslund, L., additional, Meyer, A., additional, Lipinski, M., additional, Libey, B., additional, Dornfeld, K., additional, Martin, A., additional, Gallego, M., additional, De Bie, M. K., additional, Van Rees, J. B., additional, Borleffs, C. J., additional, Thijssen, J., additional, Jukema, J. W., additional, Schalij, M. J., additional, Van Erven, L., additional, Van Der Velde, E. T., additional, Witteman, T. A., additional, Foeken, H., additional, Szili-Torok, T., additional, Akca, F., additional, Caliskan, K., additional, Ten Cate, F., additional, Michels, M., additional, Cozma, D. C., additional, Petrescu, L., additional, Mornos, C., additional, Dragulescu, S. I., additional, Groeneweg, J. A., additional, Velthuis, B. K., additional, Cox, M. G. P. J., additional, Loh, P., additional, Dooijes, D., additional, Cramer, M. J., additional, De Bakker, J. M. T., additional, Hauer, R. N. W., additional, Park, S. D., additional, Shin, S. H., additional, Woo, S. I., additional, Kwan, J., additional, Park, K. S., additional, Kim, D. H., additional, Iorio, A., additional, Vitali Serdoz, L., additional, Brun, F., additional, Daleffe, E., additional, Zecchin, M., additional, Dal Ferro, M., additional, Santangelo, S., additional, Sinagra, G. F., additional, Ouali, S., additional, Hammemi, R., additional, Hammas, S., additional, Kacem, S., additional, Gribaa, R., additional, Neffeti, E., additional, Remedi, F., additional, Boughzela, E., additional, Korantzopoulos, P., additional, Letsas, K., additional, Christogiannis, Z., additional, Kalantzi, K., additional, Ntorkos, A., additional, Goudevenos, J., additional, Foley, P. W. X., additional, Yung, L., additional, Barnes, E., additional, Kikuchi, M., additional, Ito, H., additional, Miyoshi, F., additional, Pecini, R., additional, Marott, J. M., additional, Jensen, G. B., additional, Theilade, J., additional, Mine, T., additional, Kodani, T., additional, Masuyama, T., additional, Mozos, I. M., additional, Serban, C., additional, Costea, C., additional, Susan, L., additional, Barthel, P., additional, Mueller, A., additional, Malik, M., additional, Schmidt, G., additional, Karakurt, O., additional, Kilic, H., additional, Munevver Sari, D. R., additional, Mroczek-Czernecka, D., additional, Pietrucha, A. Z., additional, Borowiec, A., additional, Wnuk, M., additional, Bzukala, I., additional, Kruszelnicka, O., additional, Konduracka, E., additional, Nessler, J., additional, Kikuchi, Y., additional, Meireles, A., additional, Gomes, C., additional, Anjo, D., additional, Roque, C., additional, Pinheiro Vieira, A., additional, Lagarto, V., additional, Hipolito Reis, A., additional, Torres, S., additional, Miller, L., additional, Vedrenne, G., additional, Bruguiere, E., additional, Redheuil, A., additional, Lavergne, T., additional, Le Heuzey, J. Y., additional, Mousseaux, E., additional, Hersi, A., additional, Alhabib, K., additional, Alfaleh, H., additional, Sulaiman, K., additional, Almahmeed, W., additional, Alsuwidi, J., additional, Amin, H., additional, Almotarreb, A., additional, Pang, H. W. K., additional, Michael, K., additional, Pereira, E. J., additional, Munt, P. W., additional, Fitzpatrick, M. F., additional, Revishvili, A. S., additional, Simonyan, G., additional, Dzhordzhikiya, T., additional, Sopov, O., additional, Kalinin, V., additional, Locati, E. T., additional, Vecchi, A. M., additional, Cattafi, G., additional, Sachero, A., additional, Lunati, M., additional, Sayah, S., additional, Alizadeh, A., additional, Nazari, N., additional, Hekmat, M., additional, Moradi, M., additional, Zeighami, M., additional, Ghanji, H., additional, Suzuki, K., additional, Takagi, M., additional, Maeda, K., additional, Tatsumi, H., additional, Vieira, P., additional, Reis, H., additional, Toth, A., additional, Vago, H., additional, Takacs, P., additional, Edes, E., additional, Marki, A., additional, Balazs, G. Y., additional, Huttl, K., additional, Merkely, B., additional, Lainis, F., additional, Buckley, M. M., additional, Johns, E. J., additional, Seifer, C. M., additional, Daba, L., additional, Liebrecht, K., additional, Piwowarska, W., additional, Toquero Ramos, J., additional, Perez Pereira, E., additional, Mitroi, C., additional, Castro Urda, V., additional, Fernandez Villanueva, J. M., additional, Corona Figueroa, A., additional, Hernandez Reina, L., additional, Fernandez Lozano, I., additional, Bartoletti, A., additional, Bocconcelli, P., additional, Giuli, S., additional, Massa, R., additional, Svetlich, C., additional, Tarsi, G., additional, Tronconi, F., additional, Vitale, E., additional, Stryjewski, P., additional, Wegrzynowska, M., additional, Lousinha, A., additional, Labandeiro, J., additional, Antunes, E., additional, Silva, S., additional, Alves, S., additional, Timoteo, A., additional, Oliveira, M., additional, Cruz Ferreira, R., additional, and Jedrzejczyk-Spaho, J., additional

Published
2011
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43. A catalogue of validated single nucleotide polymorphisms in bovine orthologs of mammalian imprinted genes and associations with beef production traits.

Author

Magee, D. A., Berkowicz, E. W., Sikora, K. M., Berry, D. P., Park, S. D. E., Kelly, A. K., Sweeney, T., Kenny, D. A., Evans, R. D., Wickham, B. W., Spillane, C., and MacHugh, D. E.

Subjects
GENOMIC imprinting, GENETIC polymorphisms, NUCLEOTIDE sequence, RAS proteins, GENE expression, CATTLE genetics, GENETIC markers, BIOLOGICAL variation
Published
2010
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46. The Short Oesophagus.

Author

Rennie, J. Basil, Land, Frank T., and Park, S. D. Scott

Published
1949

47. Gain- and loss-of-function of Rhp51, a Rad51 homolog in fission yeast, reveals dissimilarities in chromosome integrity.

Author

Kim, W J, Lee, H, Park, E J, Park, J K, and Park, S D

Abstract

Rad51 is crucial not only in homologous recombination and recombinational repair but also in normal cellular growth. To address the role of Rad51 in normal cell growth we investigated morphological changes of cells after overexpression of wild-type and a dominant negative form of Rad51 in fission yeast. Rhp51, a Rad51 homolog in Schizosaccharomyces pombe, has a highly conserved ATP-binding motif. Rhp51 K155A, which has a single substitution in this motif, failed to rescue hypersensitivity of a rhp51 mutant to methyl methanesulfonate (MMS) and UV, whereas it binds normally to Rhp51 and Rad22, a Rad52 homolog. Two distinct cellular phenotypes were observed when Rhp51 or Rhp51 K155A was overexpressed in normal cells. Overexpression of Rhp51 caused lethality in the absence of DNA-damaging agents, with acquisition of a cell cycle mutant phenotype and accumulation of a 1C DNA population. On the other hand, overexpression of Rhp51 K155A led to a delay in G(2) with decondensed nuclei, which resembled the phenotype of rhp51. The latter also exhibited MMS and UV sensitivity, indicating that Rhp51 K155A has a dominant negative effect. These results suggest an association between DNA replication and Rad51 function.

Published
2001
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48. The stress-activated MAP kinase Sty1/Spc1 and a 3'-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level.

Author

Kim, M, Lee, W, Park, J, Kim, J B, Jang, Y K, Seong, R H, Choe, S Y, and Park, S D

Abstract

Exposure of Schizosaccharomyces pombe cells to UV light results in increased uvi15(+) gene expression at both the mRNA and protein levels, leading to elevated cell survival. This UV-induced expression of the uvi15(+) gene was reduced in Deltasty1 and Deltawis1 cells lacking the stress-activated protein kinase pathway, but not in DNA damage checkpoint mutants. To further understand the cellular mechanisms responsible for this UV-induced expression, the transcription rate and mRNA half-life were investigated. Transcription run-on assays revealed that the rate of uvi15(+) transcription was increased 1.8-fold regardless of Sty1 when cells were UV irradiated. The half-life of uvi15(+) mRNA was also increased 1.5-fold after UV irradiation, but it was decreased in the Deltasty1 background for both basal and UV-induced mRNAs, indicating that the stress-activated MAPK cascade can mediate UV-induced gene expression by increasing mRNA half-life. Deletion analyses identified a 54 nt element downstream of the distal poly(A) site, which was involved in the increased half-life of uvi15(+) mRNA. These results suggest that both Sty1 and the 3'-regulatory element regulate UV-induced expression of the uvi15(+) gene at the post-transcriptional level.

Published
2000
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49. Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells.

Author

Park, E J, Kim, J H, Seong, R H, Kim, C G, Park, S D, and Hong, S H

Abstract

Using the modified screening approach in combination with expressed sequence tags, we have identified several novel cDNAs from mouse embryonic stem (ES) cells, whose expression is tissue-restricted and/or developmentally regulated. One of the cDNAs, ES18, is preferentially expressed in lymph node and thymus, and contains noteworthy features of transcriptional regulator. The expression of ES18 transcript was selectively regulated during the apoptosis of T-cell thymoma S49.1 induced by several stimuli. Interestingly, the ES18 transcript was differently regulated in the mutually antagonistic process, between dexamethasone- and A23187-induced cell death of T-cells. Moreover, the message level of ES18 was selectively enhanced by staurosporine, a broad protein kinase inhibitor, but not by other protein kinase inhibitors such as GF109203X and H89. In addition, ES18 transcript was induced by C2-ceramide, which is a mediator of both dexamethasone- and staurosporine-induced apoptotic signaling. We further showed that transient overexpression of ES18 in mouse T-cell lymphoma increased the apoptotic cell death. These data suggest that ES18 may be selectively involved in specific apoptotic processes in mouse T-cells.

Published
1999
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50. Postreplication repair: questions of its definition and possible alteration in xeroderma pigmentosum cell strains.

Author

Park, S D and Cleaver, J E

Abstract

DNA synthesis in normal cells and in excision-defective and variant xeroderma pigmentosum cells was investigated after irradiation with ultraviolet light. The sizes of DNA synthesized during brief pulses of [3H]thymidine 1-2 hr after irradiation were decreased, the xeroderma pigmentosum variant showing the smallest molecular weight. Once synthesized, however, labeled DNA increased in size at the same rat as control in all cell strains, and the rate was relatively insensitive to caffeine. After 2-3 hr, labeled DNA in each cell type reached a maximum size that was less than that in control cells, indicating the presence of long-lived blocks to DNA chain growth. This kind of experiment (pulse-chase) has in the past been used to investigate a repair process believed to be associated with the bypass of damaged sites in parental DNA: postreplication repair. We present an alternative model that does not involve a specific postreplication repair mechanism, but involve a specific postreplication repair mechanism, but involves normal chain elongation and termination mechanisms in which we conceive that dimers and other damaged sites act as well-or-nothing blocks to the progress of replication forks. No evidence could be found for any inducible process that enhanced the bypass of damaged sites.

Published
1979
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