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1. Accuracy of Computer-aided Diagnosis in Colonoscopy Varies According to Polyp Location: A Systematic Review and Meta-analysis

Author

Rizkala, Tommy, Hassan, Cesare, Mori, Yuichi, Spadaccini, Marco, Antonelli, Giulio, Dekker, Evelien, Houwen, Britt B.S.L., Pech, Oliver, Baumer, Sebastian, Rondonotti, Emanuele, Radaelli, Franco, Li, James Weiquan, von Renteln, Daniel, Misawa, Masashi, Facciorusso, Antonio, Maselli, Roberta, Carrara, Silvia, Fugazza, Alessandro, Capogreco, Antonio, Khalaf, Kareem, Patel, Harsh, Sharma, Prateek, Rex, Douglas, and Repici, Alessandro

Published
2024
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2. Expert assessment of infiltration depth and recommendation of endoscopic resection technique in early Barrett cancer

Author

Younis, Fadi, Rösch, Thomas, Beyna, Torsten, Ebigbo, Alanna, Faiss, Siegbert, May, Andrea, Pech, Oliver, Dautel, Philip, Anders, Mario, Clauditz, Till, Zimmermann‐Fraedrich, Katharina, Sehner, Susanne, and Schachschal, Guido

Abstract

Early Barrett cancer can be curatively treated by endoscopic resection. The choice of the resection technique, however—endoscopic mucosal resection (EMR) or submucosal dissection (ESD)—largely depends on the assumed infiltration depth as judged by the endoscopist. However, the accuracy of endoscopic diagnosis of the degree of cancer infiltration is not known. Three to four high‐quality images (both in overview and close‐up) from 202 of early Barrett esophagus cancer cases (82% men, mean age 66.9 years) were selected from our endoscopy database (73.3% stage T1a and 26.7% in stage T1b). Images were shown to 9 Barrett esophagus experts, with patients' clinical data (age, sex, Barrett esophagus length) and biopsy results. The experts were asked to predict infiltration depth (T1b vs. T1a), and to suggest the appropriate endoscopic resection technique (EMR or ESD, or surgery). Interobserver variability (kappa values) was also determined for these parameters. Overall positive (PPV) and negative predictive values (NPV) to diagnose T1b versus T1a infiltration were 40.7% (95% CI: 36.7, 44.8) and 79.8% (95% CI: 77.5, 81.9), respectively; kappa value was 0.41. Paris classification (kappa 0.51) and suggested treatment also varied between experts. In a post hoc analysis, only the correlation between lesions classified as invisible or flat according to the Paris classification (IIB; 25% of all cases) and the suggested resection technique was better: In this subgroup, EMR was recommended in >80% of cases, with a high complete (basal R0) resection rate (mean of 88.1%). Precise endoscopic distinction between mucosal and submucosal involvement of Barrett esophagus cancer by experts as a basis for choosing the resection technique has limited predictive values and high interobserver variability. It seems that mainly invisible/flat lesions may result in good resection outcomes when treated by EMR, but this stratification strategy has to be assessed in further studies.

Published
2024
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3. A deep learning system for detection of early Barrett's neoplasia: a model development and validation study

Author

Fockens, K N, primary, Jong, M R, additional, Jukema, J B, additional, Boers, T G W, additional, Kusters, C H J, additional, van der Putten, J A, additional, Pouw, R E, additional, Duits, L C, additional, Montazeri, N S M, additional, van Munster, S N, additional, Weusten, B L A M, additional, Alvarez Herrero, L, additional, Houben, M H M G, additional, Nagengast, W B, additional, Westerhof, J, additional, Alkhalaf, A, additional, Mallant-Hent, R C, additional, Scholten, P, additional, Ragunath, K, additional, Seewald, S, additional, Elbe, P, additional, Baldaque-Silva, F, additional, Barret, M, additional, Ortiz Fernández-Sordo, J, additional, Villarejo, G Moral, additional, Pech, O, additional, Beyna, T, additional, van der Sommen, F, additional, de With, P H, additional, de Groof, A J, additional, Bergman, J J, additional, Alkhalaf, Alaa, additional, Alvarez Herrero, Lorenza, additional, Baldaque-Silva, Francisco, additional, Barret, Maximilien, additional, Bergman, Jacques J, additional, Beyna, Torsten, additional, Bisschops, Raf, additional, Boers, Tim G, additional, Curvers, Wouter, additional, Deprez, Pierre H, additional, Duits, Lucas C, additional, Elbe, Peter, additional, Esteban, Jose M, additional, Falk, Gary W, additional, Fockens, Kiki N, additional, Ganguly, Eric, additional, Ginsberg, Gregory G, additional, de Groof, Albert J, additional, Haidry, Rehan, additional, Houben, Martin H, additional, Infantolino, Anthony, additional, Iyer, Prasad G, additional, Jong, Martijn R, additional, De Jonge, Pieter-Jan, additional, Jukema, Jelmer B, additional, Koch, Arjun K, additional, Komanduri, Srinadh, additional, Konda, Vani, additional, Kusters, Carolus H J, additional, Leclercq, Philippe, additional, Leggett, Cadman L, additional, Lemmers, Arnaud, additional, Lightdale, Charles J, additional, Mallant-Hent, Rosalie C, additional, Moral Villarejo, Guiomar, additional, Muthusamy, V Raman, additional, Nagengast, Wouter, additional, Ortiz Fernández-Sordo, Jacobo, additional, Pech, Oliver, additional, Penman, Ian, additional, Pleskow, Douglas K, additional, Pouw, Roos E, additional, van der Putten, Joost A, additional, Ragunath, Krish, additional, Scholten, Pieter, additional, Seewald, Stefan, additional, Sethi, Amritha, additional, Smith, Michael S, additional, Van der Sommen, Fons, additional, Trindade, Arvind, additional, Wani, Sachin, additional, Waxman, Irving, additional, Westerhof, Jessie, additional, Weusten, Bas L, additional, de With, Peter H N, additional, and Wolfsen, Herbert C, additional

Published
2023
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4. Accuracy of polyp characterization by artificial intelligence and endoscopists: a prospective, non-randomized study in a tertiary endoscopy center

Author

Baumer, Sebastian, primary, Streicher, Kilian, primary, Alqahtani, Saleh A., additional, Brookman-Amissah, Dominic, additional, Brunner, Monika, additional, Federle, Christoph, additional, Muehlenberg, Klaus, additional, Pfeifer, Lukas, additional, Salzberger, Andrea, additional, Schorr, Wolfgang, additional, Zustin, Jozef, additional, and Pech, Oliver, additional

Published
2023
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5. Updated German guideline on diagnosis and treatment of squamous cell carcinoma and adenocarcinoma of the esophagus

Author

Porschen, Rainer, Fischbach, Wolfgang, Gockel, Ines, Hollerbach, Stephan, Hölscher, Arnulf, Jansen, Petra Lynen, Miehlke, Stephan, Pech, Oliver, Stahl, Michael, Vanhoefer, Udo, and Ebert, Matthias P. A.

Abstract

Diagnosis and therapy of esophageal carcinoma is challenging and requires a multidisciplinary approach. The purpose of the updated German guideline “Diagnosis and Treatment of Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus—version 3.1” is to provide practical and evidence‐based advice for the management of patients with esophageal cancer. Recommendations were developed by a multidisciplinary expert panel based on an extensive and systematic evaluation of the published medical literature and the application of well‐established methodologies (e.g. Oxford evidence grading scheme, grading of recommendations). Accurate diagnostic evaluation of the primary tumor as well as lymph node and distant metastases is required in order to guide patients to a stage‐appropriate therapy after the initial diagnosis of esophageal cancer. In high‐grade intraepithelial neoplasia or mucosal carcinoma endoscopic resection shall be performed. Whether endoscopic resection is the definitive therapeutic measure depends on the histopathological evaluation of the resection specimen. Esophagectomy should be performed minimally invasive or in combination with open procedures (hybrid technique). Because the prognosis in locally advanced esophageal carcinoma is poor with surgery alone, multimodality therapy is recommended. In locally advanced adenocarcinomas of the esophagus or esophagogastric junction, perioperative chemotherapy or preoperative radiochemotherapy should be administered. In locally advanced squamous cell carcinomas of the esophagus, preoperative radiochemotherapy followed by complete resection or definitive radiochemotherapy without surgery should be performed. In the case of residual tumor in the resection specimen after neoadjuvant radiochemotherapy and R0 resection of squamous cell carcinoma or adenocarcinoma, adjuvant immunotherapy with nivolumab should be given. Systemic palliative treatment options (chemotherapy, chemotherapy plus immunotherapy, immunotherapy alone) in unresectable or metastastic esophageal cancer depend on histology and are stratified according to PD‐L1 and/or Her2 expression.

Published
2024
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6. Towards a robust and compact deep learning system for primary detection of early Barrett’s neoplasia: Initial image‐based results of training on a multi‐center retrospectively collected data set

Author

Fockens, Kiki N., primary, Jukema, Jelmer B., additional, Boers, Tim, additional, Jong, Martijn R., additional, van der Putten, Joost A., additional, Pouw, Roos E., additional, Weusten, Bas L. A. M., additional, Alvarez Herrero, Lorenza, additional, Houben, Martin H. M. G., additional, Nagengast, Wouter B., additional, Westerhof, Jessie, additional, Alkhalaf, Alaa, additional, Mallant, Rosalie, additional, Ragunath, Krish, additional, Seewald, Stefan, additional, Elbe, Peter, additional, Barret, Maximilien, additional, Ortiz Fernández‐Sordo, Jacobo, additional, Pech, Oliver, additional, Beyna, Torsten, additional, van der Sommen, Fons, additional, de With, Peter H., additional, de Groof, A. Jeroen, additional, and Bergman, Jacques J., additional

Published
2023
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7. Wide-area transepithelial sampling with computer-assisted analysis to detect high grade dysplasia and cancer in Barrett's esophagus: a multicenter randomized study

Author

van Munster, Sanne N, Leclercq, Philippe, Haidry, Rehan, Messmann, Helmut, Probst, Andreas, Ragunath, Krish, Bhandari, Pradeep, Repici, Alessandro, Munoz-Navas, Miguel, Seewald, Stefan, Lemmers, Arnaud, Fernández-Esparrach, Glòria, Pech, Oliver, Schoon, Erik J, Kariv, Revital, Neuhaus, Horst, Weusten, Bas L A M, Siersema, Peter D, Correale, Loredana, Meijer, Sybren L, de Hertogh, Gert, Bergman, Jacques J G H M, Hassan, Cesare, Bisschops, Raf, van Munster, Sanne N, Leclercq, Philippe, Haidry, Rehan, Messmann, Helmut, Probst, Andreas, Ragunath, Krish, Bhandari, Pradeep, Repici, Alessandro, Munoz-Navas, Miguel, Seewald, Stefan, Lemmers, Arnaud, Fernández-Esparrach, Glòria, Pech, Oliver, Schoon, Erik J, Kariv, Revital, Neuhaus, Horst, Weusten, Bas L A M, Siersema, Peter D, Correale, Loredana, Meijer, Sybren L, de Hertogh, Gert, Bergman, Jacques J G H M, Hassan, Cesare, and Bisschops, Raf

Abstract

BACKGROUND: Current surveillance for Barrett's esophagus (BE), consisting of four-quadrant random forceps biopsies (FBs), has an inherent risk of sampling error. Wide-area transepithelial sampling (WATS) may increase detection of high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC). In this multicenter randomized trial, we aimed to evaluate WATS as a substitute for FB.METHODS: Patients with known BE and a recent history of dysplasia, without visible lesions, at 17 hospitals were randomized to receive either WATS followed by FB or vice versa. All WATS samples were examined, with computer assistance, by at least two experienced pathologists at the CDx Diagnostics laboratory. Similarly, all FBs were examined by two expert pathologists. The primary end point was concordance/discordance for detection of HGD/EAC between the two techniques.RESULTS: 172 patients were included, of whom 21 had HGD/EAC detected by both modalities, 18 had HGD/EAC detected by WATS but missed by FB, and 12 were detected by FB but missed by WATS. The detection rate of HGD/EAC did not differ between WATS and FB (P = 0.36). Using WATS as an adjunct to FB significantly increased the detection of HGD/EAC vs. FB alone (absolute increase 10 % [95 %CI 6 % to 16 %]). Mean procedural times in minutes for FB alone, WATS alone, and the combination were 6.6 (95 %CI 5.9 to 7.1), 4.9 (95 %CI 4.1 to 5.4), and 11.2 (95 %CI 10.5 to 14.0), respectively.CONCLUSIONS: Although the combination of WATS and FB increases dysplasia detection in a population of BE patients enriched for dysplasia, we did not find a statistically significant difference between WATS and FB for the detection of HGD/EAC as single modality.

Published
2023

8. Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Author

MS MDL 1, Cancer, Weusten, Bas L.A.M., Bisschops, Raf, Dinis-Ribeiro, Mario, Di Pietro, Massimiliano, Pech, Oliver, Spaander, Manon C.W., Baldaque-Silva, Francisco, Barret, Maximilien, Coron, Emmanuel, Fernández-Esparrach, Glòria, Fitzgerald, Rebecca C., Jansen, Marnix, Jovani, Manol, Marques-De-Sa, Ines, Rattan, Arti, Tan, W. Keith, Verheij, Eva P.D., Zellenrath, Pauline A., Triantafyllou, Konstantinos, Pouw, Roos E., MS MDL 1, Cancer, Weusten, Bas L.A.M., Bisschops, Raf, Dinis-Ribeiro, Mario, Di Pietro, Massimiliano, Pech, Oliver, Spaander, Manon C.W., Baldaque-Silva, Francisco, Barret, Maximilien, Coron, Emmanuel, Fernández-Esparrach, Glòria, Fitzgerald, Rebecca C., Jansen, Marnix, Jovani, Manol, Marques-De-Sa, Ines, Rattan, Arti, Tan, W. Keith, Verheij, Eva P.D., Zellenrath, Pauline A., Triantafyllou, Konstantinos, and Pouw, Roos E.

Published
2023

9. Endoscopic submucosal dissection techniques and technology: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review

Author

MS MDL 1, Cancer, Libânio, Diogo, Pimentel-Nunes, Pedro, Bastiaansen, Barbara, Bisschops, Raf, Bourke, Michael J, Deprez, Pierre H, Esposito, Gianluca, Lemmers, Arnaud, Leclercq, Philippe, Maselli, Roberta, Messmann, Helmut, Pech, Oliver, Pioche, Mathieu, Vieth, Michael, Weusten, Bas L A M, Fuccio, Lorenzo, Bhandari, Pradeep, Dinis-Ribeiro, Mario, MS MDL 1, Cancer, Libânio, Diogo, Pimentel-Nunes, Pedro, Bastiaansen, Barbara, Bisschops, Raf, Bourke, Michael J, Deprez, Pierre H, Esposito, Gianluca, Lemmers, Arnaud, Leclercq, Philippe, Maselli, Roberta, Messmann, Helmut, Pech, Oliver, Pioche, Mathieu, Vieth, Michael, Weusten, Bas L A M, Fuccio, Lorenzo, Bhandari, Pradeep, and Dinis-Ribeiro, Mario

Published
2023

10. Towards a robust and compact deep learning system for primary detection of early Barrett’s neoplasia: Initial image-based results of training on a multi-center retrospectively collected data set

Author

MS MDL 1, Cancer, Fockens, Kiki N., Jukema, Jelmer B., Boers, Tim, Jong, Martijn R., van der Putten, Joost A., Pouw, Roos E., Weusten, Bas L.A.M., Alvarez Herrero, Lorenza, Houben, Martin H.M.G., Nagengast, Wouter B., Westerhof, Jessie, Alkhalaf, Alaa, Mallant, Rosalie, Ragunath, Krish, Seewald, Stefan, Elbe, Peter, Barret, Maximilien, Ortiz Fernández-Sordo, Jacobo, Pech, Oliver, Beyna, Torsten, van der Sommen, Fons, de With, Peter H., de Groof, A. Jeroen, Bergman, Jacques J., MS MDL 1, Cancer, Fockens, Kiki N., Jukema, Jelmer B., Boers, Tim, Jong, Martijn R., van der Putten, Joost A., Pouw, Roos E., Weusten, Bas L.A.M., Alvarez Herrero, Lorenza, Houben, Martin H.M.G., Nagengast, Wouter B., Westerhof, Jessie, Alkhalaf, Alaa, Mallant, Rosalie, Ragunath, Krish, Seewald, Stefan, Elbe, Peter, Barret, Maximilien, Ortiz Fernández-Sordo, Jacobo, Pech, Oliver, Beyna, Torsten, van der Sommen, Fons, de With, Peter H., de Groof, A. Jeroen, and Bergman, Jacques J.

Published
2023

12. eQTL Set–Based Association Analysis Identifies Novel Susceptibility Loci for Barrett Esophagus and Esophageal Adenocarcinoma

Author

Wang, Xiaoyu, primary, Gharahkhani, Puya, additional, Levine, David M., additional, Fitzgerald, Rebecca C., additional, Gockel, Ines, additional, Corley, Douglas A., additional, Risch, Harvey A., additional, Bernstein, Leslie, additional, Chow, Wong-Ho, additional, Onstad, Lynn, additional, Shaheen, Nicholas J., additional, Lagergren, Jesper, additional, Hardie, Laura J., additional, Wu, Anna H., additional, Pharoah, Paul D.P., additional, Liu, Geoffrey, additional, Anderson, Lesley A., additional, Iyer, Prasad G., additional, Gammon, Marilie D., additional, Caldas, Carlos, additional, Ye, Weimin, additional, Barr, Hugh, additional, Moayyedi, Paul, additional, Harrison, Rebecca, additional, Watson, R.G. Peter, additional, Attwood, Stephen, additional, Chegwidden, Laura, additional, Love, Sharon B., additional, MacDonald, David, additional, deCaestecker, John, additional, Prenen, Hans, additional, Ott, Katja, additional, Moebus, Susanne, additional, Venerito, Marino, additional, Lang, Hauke, additional, Mayershofer, Rupert, additional, Knapp, Michael, additional, Veits, Lothar, additional, Gerges, Christian, additional, Weismüller, Josef, additional, Reeh, Matthias, additional, Nöthen, Markus M., additional, Izbicki, Jakob R., additional, Manner, Hendrik, additional, Neuhaus, Horst, additional, Rösch, Thomas, additional, Böhmer, Anne C., additional, Hölscher, Arnulf H., additional, Anders, Mario, additional, Pech, Oliver, additional, Schumacher, Brigitte, additional, Schmidt, Claudia, additional, Schmidt, Thomas, additional, Noder, Tania, additional, Lorenz, Dietmar, additional, Vieth, Michael, additional, May, Andrea, additional, Hess, Timo, additional, Kreuser, Nicole, additional, Becker, Jessica, additional, Ell, Christian, additional, Tomlinson, Ian, additional, Palles, Claire, additional, Jankowski, Janusz A., additional, Whiteman, David C., additional, MacGregor, Stuart, additional, Schumacher, Johannes, additional, Vaughan, Thomas L., additional, Buas, Matthew F., additional, and Dai, James Y., additional

Published
2022
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14. Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2022

Author

UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de gastro-entérologie, Pimentel-Nunes, Pedro, Libânio, Diogo, Bastiaansen, Barbara A. J., Bhandari, Pradeep, Bisschops, Raf, Bourke, Michael J., Esposito, Gianluca, Lemmers, Arnaud, Maselli, Roberta, Messmann, Helmut, Pech, Oliver, Pioche, Mathieu, Vieth, Michael, Weusten, Bas L. A. M., van Hooft, Jeanin E., Deprez, Pierre H., Dinis-Ribeiro, Mario, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de gastro-entérologie, Pimentel-Nunes, Pedro, Libânio, Diogo, Bastiaansen, Barbara A. J., Bhandari, Pradeep, Bisschops, Raf, Bourke, Michael J., Esposito, Gianluca, Lemmers, Arnaud, Maselli, Roberta, Messmann, Helmut, Pech, Oliver, Pioche, Mathieu, Vieth, Michael, Weusten, Bas L. A. M., van Hooft, Jeanin E., Deprez, Pierre H., and Dinis-Ribeiro, Mario

Abstract

no abstract available

Published
2022

15. eQTL Set-Based Association Analysis Identifies Novel Susceptibility Loci for Barrett Esophagus and Esophageal Adenocarcinoma

Author

Wang, Xiaoyu, Gharahkhani, Puya, Levine, David M., Fitzgerald, Rebecca C., Gockel, Ines, Corley, Douglas A., Risch, Harvey A., Bernstein, Leslie, Chow, Wong-Ho, Onstad, Lynn, Shaheen, Nicholas J., Lagergren, Jesper, Hardie, Laura J., Wu, Anna H., Pharoah, Paul D. P., Liu, Geoffrey, Anderson, Lesley A., Iyer, Prasad G., Gammon, Marilie D., Caldas, Carlos, Ye, Weimin, Barr, Hugh, Moayyedi, Paul, Harrison, Rebecca, Watson, R. G. Peter, Attwood, Stephen, Chegwidden, Laura, Love, Sharon B., MacDonald, David, DeCaestecker, John, Prenen, Hans, Ott, Katja, Moebus, Susanne, Venerito, Marino, Lang, Hauke, Mayershofer, Rupert, Knapp, Michael, Veits, Lothar, Gerges, Christian, Weismueller, Josef, Reeh, Matthias, Noethen, Markus M., Izbicki, Jakob R., Manner, Hendrik, Neuhaus, Horst, Roesch, Thomas, Boehmer, Anne C., Hoelscher, Arnulf H., Anders, Mario, Pech, Oliver, Schumacher, Brigitte, Schmidt, Claudia, Schmidt, Thomas, Noder, Tania, Lorenz, Dietmar, Vieth, Michael, May, Andrea, Hess, Timo, Kreuser, Nicole, Becker, Jessica, Ell, Christian, Tomlinson, Ian, Palles, Claire, Jankowski, Janusz A., Whiteman, David C., MacGregor, Stuart, Schumacher, Johannes, Vaughan, Thomas L., Buas, Matthew F., Dai, James Y., Wang, Xiaoyu, Gharahkhani, Puya, Levine, David M., Fitzgerald, Rebecca C., Gockel, Ines, Corley, Douglas A., Risch, Harvey A., Bernstein, Leslie, Chow, Wong-Ho, Onstad, Lynn, Shaheen, Nicholas J., Lagergren, Jesper, Hardie, Laura J., Wu, Anna H., Pharoah, Paul D. P., Liu, Geoffrey, Anderson, Lesley A., Iyer, Prasad G., Gammon, Marilie D., Caldas, Carlos, Ye, Weimin, Barr, Hugh, Moayyedi, Paul, Harrison, Rebecca, Watson, R. G. Peter, Attwood, Stephen, Chegwidden, Laura, Love, Sharon B., MacDonald, David, DeCaestecker, John, Prenen, Hans, Ott, Katja, Moebus, Susanne, Venerito, Marino, Lang, Hauke, Mayershofer, Rupert, Knapp, Michael, Veits, Lothar, Gerges, Christian, Weismueller, Josef, Reeh, Matthias, Noethen, Markus M., Izbicki, Jakob R., Manner, Hendrik, Neuhaus, Horst, Roesch, Thomas, Boehmer, Anne C., Hoelscher, Arnulf H., Anders, Mario, Pech, Oliver, Schumacher, Brigitte, Schmidt, Claudia, Schmidt, Thomas, Noder, Tania, Lorenz, Dietmar, Vieth, Michael, May, Andrea, Hess, Timo, Kreuser, Nicole, Becker, Jessica, Ell, Christian, Tomlinson, Ian, Palles, Claire, Jankowski, Janusz A., Whiteman, David C., MacGregor, Stuart, Schumacher, Johannes, Vaughan, Thomas L., Buas, Matthew F., and Dai, James Y.

Abstract

Background: Over 20 susceptibility single-nucleotide poly-morphisms (SNP) have been identified for esophageal adenocarcinoma (EAC) and its precursor, Barrett esophagus (BE), explaining a small portion of heritability.Methods: Using genetic data from 4,323 BE and 4,116 EAC patients aggregated by international consortia including the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), we conducted a comprehensive transcriptome-wide association study (TWAS) for BE/EAC, leveraging Genotype Tissue Expression (GTEx) gene-expression data from six tissue types of plausible relevance to EAC etiology: mucosa and muscularis from the esophagus, gastroesophageal (GE) junction, stomach, whole blood, and visceral adipose. Two analytical approaches were taken: standard TWAS using the predicted gene expression from local expression quantitative trait loci (eQTL), and set-based SKAT association using selected eQTLs that predict the gene expression. Results: Although the standard approach did not identify significant signals, the eQTL set-based approach identified eight novel associations, three of which were validated in independent external data (eQTL SNP sets for EXOC3, ZNF641, and HSP90AA1). Conclusions: This study identified novel genetic susceptibility loci for EAC and BE using an eQTL set-based genetic association approach.Impact: This study expanded the pool of genetic susceptibility loci for EAC and BE, suggesting the potential of the eQTL set-based genetic association approach as an alternative method for TWAS analysis.

Published
2022

16. Wide-area transepithelial sampling with computer-assisted analysis to detect high grade dysplasia and cancer in Barrettʼs esophagus: A Multi-Center, Randomized Study

Author

MS MDL 1, Cancer, Van Munster, Sanne, Leclercq, Philippe, Haidry, Rehan, Messmann, Helmut, Probst, Andreas, Ragunath, Krish, Bhandari, Pradeep, Repici, Alessandro, Munoz-Navas, Miguel, Seewald, Stefan, Lemmers, Arnaud, Fernández-Esparrach, Glòria, Pech, Oliver, Schoon, Erik J., Kariv, Revital, Neuhaus, Horst, Weusten, Bas L.A.M., Siersema, Peter D., Correale, Loredana, Meijer, Sybren L., De Hertogh, Gert, Bergman, Jacques Jghm, Hassan, Cesare, Bisschops, Raf, MS MDL 1, Cancer, Van Munster, Sanne, Leclercq, Philippe, Haidry, Rehan, Messmann, Helmut, Probst, Andreas, Ragunath, Krish, Bhandari, Pradeep, Repici, Alessandro, Munoz-Navas, Miguel, Seewald, Stefan, Lemmers, Arnaud, Fernández-Esparrach, Glòria, Pech, Oliver, Schoon, Erik J., Kariv, Revital, Neuhaus, Horst, Weusten, Bas L.A.M., Siersema, Peter D., Correale, Loredana, Meijer, Sybren L., De Hertogh, Gert, Bergman, Jacques Jghm, Hassan, Cesare, and Bisschops, Raf

Published
2022

17. Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022

Author

MS MDL 1, Cancer, Pimentel-Nunes, Pedro, Libânio, Diogo, Bastiaansen, Barbara A J, Bhandari, Pradeep, Bisschops, Raf, Bourke, Michael J, Esposito, Gianluca, Lemmers, Arnaud, Maselli, Roberta, Messmann, Helmut, Pech, Oliver, Pioche, Mathieu, Vieth, Michael, Weusten, Bas L A M, van Hooft, Jeanin E, Deprez, Pierre H, Dinis-Ribeiro, Mario, MS MDL 1, Cancer, Pimentel-Nunes, Pedro, Libânio, Diogo, Bastiaansen, Barbara A J, Bhandari, Pradeep, Bisschops, Raf, Bourke, Michael J, Esposito, Gianluca, Lemmers, Arnaud, Maselli, Roberta, Messmann, Helmut, Pech, Oliver, Pioche, Mathieu, Vieth, Michael, Weusten, Bas L A M, van Hooft, Jeanin E, Deprez, Pierre H, and Dinis-Ribeiro, Mario

Published
2022

18. Consensus Statements for Management of Barrett's Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process

Author

Bennett, Cathy, Vakil, Nimish, Bergman, Jacques, Harrison, Rebecca, Odze, Robert, Vieth, Michael, Sanders, Scott, Gay, Laura, Pech, Oliver, Longcroft–Wheaton, Gaius, Romero, Yvonne, Inadomi, John, Tack, Jan, Corley, Douglas A., Manner, Hendrik, Green, Susi, Al Dulaimi, David, Ali, Haythem, Allum, Bill, Anderson, Mark, Curtis, Howard, Falk, Gary, Fennerty, M. Brian, Fullarton, Grant, Krishnadath, Kausilia, Meltzer, Stephen J., Armstrong, David, Ganz, Robert, Cengia, Gianpaolo, Going, James J., Goldblum, John, Gordon, Charles, Grabsch, Heike, Haigh, Chris, Hongo, Michio, Johnston, David, Forbes–Young, Ricky, Kay, Elaine, Kaye, Philip, Lerut, Toni, Lovat, Laurence B., Lundell, Lars, Mairs, Philip, Shimoda, Tadakuza, Spechler, Stuart, Sontag, Stephen, Malfertheiner, Peter, Murray, Iain, Nanji, Manoj, Poller, David, Ragunath, Krish, Regula, Jaroslaw, Cestari, Renzo, Shepherd, Neil, Singh, Rajvinder, Stein, Hubert J., Talley, Nicholas J., Galmiche, Jean–Paul, Tham, Tony C.K., Watson, Peter, Yerian, Lisa, Rugge, Massimo, Rice, Thomas W., Hart, John, Gittens, Stuart, Hewin, David, Hochberger, Juergen, Kahrilas, Peter, Preston, Sean, Sampliner, Richard, Sharma, Prateek, Stuart, Robert, Wang, Kenneth, Waxman, Irving, Abley, Chris, Loft, Duncan, Penman, Ian, Shaheen, Nicholas J., Chak, Amitabh, Davies, Gareth, Dunn, Lorna, Falck–Ytter, Yngve, Decaestecker, John, Bhandari, Pradeep, Ell, Christian, Griffin, S. Michael, Attwood, Stephen, Barr, Hugh, Allen, John, Ferguson, Mark K., Moayyedi, Paul, and Jankowski, Janusz A.Z.

Published
2012
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20. Материалы конференции Gastro Update Eвропа 2020, 4–5 сентября 2020 г

Author

Tytgat, N. J. Guido, Malfertheiner, Peter, Rogler, Gerhard, Regula, Jaroslaw, Pech, Oliver, Bruno, Marco, Kaminski, Michal, Layer, Peter, Tack, Jan, and Gastroenterology and Hepatology

Abstract

This narrative review summarizes a selection of clinically-important novel gastrointestinal developments, presented and discussed at the virtual Gastro Update Europe. The selected topics, fully referenced, reflect what the distinguished faculty considered of vital importance to be communicated to the astute busy gastro-hep clinician who is eager to stay abreast of important novel developments. Whenever appropriate a personal comment or addition was added to further raise the educational value of this review. Given its narrative character, statements and conclusions are largely expert opinion-based, and referencing within this summary is limited to the included slide images.

Published
2021

21. Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma

Author

Dighe, Shruti G., Chen, Jianhong, Yan, Li, He, Qianchuan, Gharahkhani, Puya, Onstad, Lynn, Levine, David M., Palles, Claire, Ye, Weimin, Gammon, Marilie D., Iyer, Prasad G., Anderson, Lesley A., Liu, Geoffrey, Wu, Anna H., Dai, James Y., Chow, Wong-Ho, Risch, Harvey A., Lagergren, Jesper, Shaheen, Nicholas J., Bernstein, Leslie, Corley, Douglas A., Prenen, Hans, DeCaestecker, John, MacDonald, David, Moayyedi, Paul, Barr, Hugh, Love, Sharon B., Chegwidden, Laura, Attwood, Stephen, Watson, Peter, Harrison, Rebecca, Ott, Katja, Moebus, Susanne, Venerito, Marino, Lang, Hauke, Mayershofer, Rupert, Knapp, Michael, Veits, Lothar, Gerges, Christian, Weismueller, Josef, Gockel, Ines, Vashist, Yogesh, Noethen, Markus M., Izbicki, Jakob R., Manner, Hendrik, Neuhaus, Horst, Roesch, Thomas, Boehmer, Anne C., Hoelscher, Arnulf H., Anders, Mario, Pech, Oliver, Schumacher, Brigitte, Schmidt, Claudia, Schmidt, Thomas, Noder, Tania, Lorenz, Dietmar, Vieth, Michael, May, Andrea, Hess, Timo, Kreuser, Nicole, Becker, Jessica, Ell, Christian, Ambrosone, Christine B., Moysich, Kirsten B., MacGregor, Stuart, Tomlinson, Ian, Whiteman, David C., Jankowski, Janusz, Schumacher, Johannes, Vaughan, Thomas L., Madeleine, Margaret M., Hardie, Laura J., Buas, Matthew F., Dighe, Shruti G., Chen, Jianhong, Yan, Li, He, Qianchuan, Gharahkhani, Puya, Onstad, Lynn, Levine, David M., Palles, Claire, Ye, Weimin, Gammon, Marilie D., Iyer, Prasad G., Anderson, Lesley A., Liu, Geoffrey, Wu, Anna H., Dai, James Y., Chow, Wong-Ho, Risch, Harvey A., Lagergren, Jesper, Shaheen, Nicholas J., Bernstein, Leslie, Corley, Douglas A., Prenen, Hans, DeCaestecker, John, MacDonald, David, Moayyedi, Paul, Barr, Hugh, Love, Sharon B., Chegwidden, Laura, Attwood, Stephen, Watson, Peter, Harrison, Rebecca, Ott, Katja, Moebus, Susanne, Venerito, Marino, Lang, Hauke, Mayershofer, Rupert, Knapp, Michael, Veits, Lothar, Gerges, Christian, Weismueller, Josef, Gockel, Ines, Vashist, Yogesh, Noethen, Markus M., Izbicki, Jakob R., Manner, Hendrik, Neuhaus, Horst, Roesch, Thomas, Boehmer, Anne C., Hoelscher, Arnulf H., Anders, Mario, Pech, Oliver, Schumacher, Brigitte, Schmidt, Claudia, Schmidt, Thomas, Noder, Tania, Lorenz, Dietmar, Vieth, Michael, May, Andrea, Hess, Timo, Kreuser, Nicole, Becker, Jessica, Ell, Christian, Ambrosone, Christine B., Moysich, Kirsten B., MacGregor, Stuart, Tomlinson, Ian, Whiteman, David C., Jankowski, Janusz, Schumacher, Johannes, Vaughan, Thomas L., Madeleine, Margaret M., Hardie, Laura J., and Buas, Matthew F.

Abstract

Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. Central obesity, a key BE/EAC risk factor, is linked to systemic inflammation, altered hormonal signaling and insulin-like growth factor (IGF) axis dysfunction. Here, we assessed IGF-related genetic variation and risk of BE and EAC. Principal component analysis was employed to evaluate pathway-level and gene-level associations with BE/EAC, using genotypes for 270 single-nucleotide polymorphisms (SNPs) in or near 12 IGF-related genes, ascertained from 3295 BE cases, 2515 EAC cases and 3207 controls in the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) GWAS. Gene-level signals were assessed using Multi-marker Analysis of GenoMic Annotation (MAGMA) and SNP summary statistics from BEACON and an expanded GWAS meta-analysis (6167 BE cases, 4112 EAC cases, 17 159 controls). Global variation in the IGF pathway was associated with risk of BE (P = 0.0015). Gene-level associations with BE were observed for GHR (growth hormone receptor; P = 0.00046, false discovery rate q = 0.0056) and IGF1R (IGF1 receptor; P = 0.0090, q = 0.0542). These gene-level signals remained significant at q < 0.1 when assessed using data from the largest available BE/EAC GWAS metaanalysis. No significant associations were observed for EAC. This study represents the most comprehensive evaluation to date of inherited genetic variation in the IGF pathway and BE/EAC risk, providing novel evidence that variation in two genes encoding cell-surface receptors, GHR and IGF1R, may influence risk of BE.

Published
2021

24. Endoscopic resection of early oesophageal cancer

Author

Pech, Oliver, May, Andrea, Rabenstein, Thomas, and Ell, Christian

Subjects
Esophageal cancer -- Care and treatment, Esophageal cancer -- Diagnosis, Esophagoscopy -- Usage, Endoscopic surgery -- Usage, Squamous cell carcinoma -- Diagnosis, Health
Published
2007

25. Germline variation in the insulin-like growth factor pathway and risk of Barrett’s esophagus and esophageal adenocarcinoma

Author

Dighe, Shruti G, primary, Chen, Jianhong, additional, Yan, Li, additional, He, Qianchuan, additional, Gharahkhani, Puya, additional, Onstad, Lynn, additional, Levine, David M, additional, Palles, Claire, additional, Ye, Weimin, additional, Gammon, Marilie D, additional, Iyer, Prasad G, additional, Anderson, Lesley A, additional, Liu, Geoffrey, additional, Wu, Anna H, additional, Dai, James Y, additional, Chow, Wong-Ho, additional, Risch, Harvey A, additional, Lagergren, Jesper, additional, Shaheen, Nicholas J, additional, Bernstein, Leslie, additional, Corley, Douglas A, additional, Prenen, Hans, additional, deCaestecker, John, additional, MacDonald, David, additional, Moayyedi, Paul, additional, Barr, Hugh, additional, Love, Sharon B, additional, Chegwidden, Laura, additional, Attwood, Stephen, additional, Watson, Peter, additional, Harrison, Rebecca, additional, Ott, Katja, additional, Moebus, Susanne, additional, Venerito, Marino, additional, Lang, Hauke, additional, Mayershofer, Rupert, additional, Knapp, Michael, additional, Veits, Lothar, additional, Gerges, Christian, additional, Weismüller, Josef, additional, Gockel, Ines, additional, Vashist, Yogesh, additional, Nöthen, Markus M, additional, Izbicki, Jakob R, additional, Manner, Hendrik, additional, Neuhaus, Horst, additional, Rösch, Thomas, additional, Böhmer, Anne C, additional, Hölscher, Arnulf H, additional, Anders, Mario, additional, Pech, Oliver, additional, Schumacher, Brigitte, additional, Schmidt, Claudia, additional, Schmidt, Thomas, additional, Noder, Tania, additional, Lorenz, Dietmar, additional, Vieth, Michael, additional, May, Andrea, additional, Hess, Timo, additional, Kreuser, Nicole, additional, Becker, Jessica, additional, Ell, Christian, additional, Ambrosone, Christine B, additional, Moysich, Kirsten B, additional, MacGregor, Stuart, additional, Tomlinson, Ian, additional, Whiteman, David C, additional, Jankowski, Janusz, additional, Schumacher, Johannes, additional, Vaughan, Thomas L, additional, Madeleine, Margaret M, additional, Hardie, Laura J, additional, and Buas, Matthew F, additional

Published
2020
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26. 1016 DOMAIN-SPECIFIC PRETRAINING OF DEEP LEARNING SYSTEMS IN GASTROINTESTINAL ENDOSCOPY IMPROVES PERFORMANCE OVER CURRENT STATE-OF-THE-ART PRETRAINING METHODS

Author

Fockens, Kiki, Boers, Tim G., Jukema, Jelmer, Jong, Martijn R., Kusters, Koen C., Van Der Putten, Joost, Struyvenberg, Maarten, Pouw, Roos E., Duits, Lucas C., Weusten, Bas L., Herrero, L. Alvarez, Houben, Martin H., Nagengast, Wouter B., Westerhof, Jessie, Alkhalaf, A., Mallant-Hent, Rosalie, Scholten, Pieter, Ragunath, Krish, Seewald, Stefan, Elbe, Peter, Baldaque-Silva, Francisco, Barret, Maximilien, Fernández-Sordo, Jacobo Ortiz, Villarejo, Guiomar Moral, Pech, Oliver, Beyna, Torsten, Van Der Sommen, Fons, De With, P.H.N., De Groof, Jeroen, and Bergman, Jacques

Published
2023
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28. Deep-Learning System Detects Neoplasia in Patients With Barrett’s Esophagus With Higher Accuracy Than Endoscopists in a Multistep Training and Validation Study With Benchmarking

Author

de Groof, Albert J., primary, Struyvenberg, Maarten R., additional, van der Putten, Joost, additional, van der Sommen, Fons, additional, Fockens, Kiki N., additional, Curvers, Wouter L., additional, Zinger, Sveta, additional, Pouw, Roos E., additional, Coron, Emmanuel, additional, Baldaque-Silva, Francisco, additional, Pech, Oliver, additional, Weusten, Bas, additional, Meining, Alexander, additional, Neuhaus, Horst, additional, Bisschops, Raf, additional, Dent, John, additional, Schoon, Erik J., additional, de With, Peter H., additional, and Bergman, Jacques J., additional

Published
2020
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32. The Argos project: the development of a computer-aided detection system to improve detection of Barrett's neoplasia on white light endoscopy

Author

Groof, Jeroen de, van der Sommen, Fons, van der Putten, Joost, Struyvenberg, Maarten R., Zinger, Sveta, Curvers, Wouter L., Pech, Oliver, Meining, Alexander, Neuhaus, Horst, Bisschops, Raf, Schoon, Erik J., de With, Peter H., Bergman, Jacques J., Groof, Jeroen de, van der Sommen, Fons, van der Putten, Joost, Struyvenberg, Maarten R., Zinger, Sveta, Curvers, Wouter L., Pech, Oliver, Meining, Alexander, Neuhaus, Horst, Bisschops, Raf, Schoon, Erik J., de With, Peter H., and Bergman, Jacques J.

Abstract

Background: Computer-aided detection (CAD) systems might assist endoscopists in the recognition of Barrett's neoplasia. Aim: To develop a CAD system using endoscopic images of Barrett's neoplasia. Methods: White light endoscopy (WLE) overview images of 40 neoplastic Barrett's lesions and 20 non-dysplastic Barret's oesophagus (NDBO) patients were prospectively collected. Experts delineated all neoplastic images. The overlap area of at least four delineations was labelled as the ‘sweet spot’. The area with at least one delineation was labelled as the ‘soft spot’. The CAD system was trained on colour and texture features. Positive features were taken from the sweet spot and negative features from NDBO images. Performance was evaluated using leave-one-out cross-validation. Outcome parameters were diagnostic accuracy of the CAD system per image, and localization of the expert soft spot by CAD delineation (localization score) and its indication of preferred biopsy location (red-flag indication score). Results: Accuracy, sensitivity and specificity for detection were 92, 95 and 85%, respectively. The system localized and red-flagged the soft spot in 100 and 90%, respectively. Conclusion: This uniquely trained and validated CAD system detected and localized early Barrett's neoplasia on WLE images with high accuracy. This is an important step towards real-time automated detection of Barrett's neoplasia.

Published
2019

33. Quality indicators for Barrett’s endotherapy (QBET): UK consensus statements for patients undergoing endoscopic therapy for Barrett’s neoplasia

Author

Alzoubaidi, Durayd, primary, Ragunath, Krish, additional, Wani, Sachin, additional, Penman, Ian D, additional, Trudgill, Nigel John, additional, Jansen, Marnix, additional, Banks, Matthew, additional, Bhandari, Pradeep, additional, Morris, Allan John, additional, Willert, Robert, additional, Boger, Phil, additional, Smart, Howard L, additional, Ravi, Narayanasamy, additional, Dunn, Jason, additional, Gordon, Charles, additional, Mannath, Jayan, additional, Mainie, Inder, additional, di Pietro, Massi, additional, Veitch, Andrew M, additional, Thorpe, Sally, additional, Magee, Cormac, additional, Everson, Martin, additional, Sami, Sarmed, additional, Bassett, Paul, additional, Graham, David, additional, Attwood, Stephen, additional, Pech, Oliver, additional, Sharma, Prateek, additional, Lovat, Laurence B, additional, and Haidry, Rehan, additional

Published
2019
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34. The Argos project: The development of a computer‐aided detection system to improve detection of Barrett's neoplasia on white light endoscopy

Author

de Groof, Jeroen, primary, van der Sommen, Fons, additional, van der Putten, Joost, additional, Struyvenberg, Maarten R, additional, Zinger, Sveta, additional, Curvers, Wouter L, additional, Pech, Oliver, additional, Meining, Alexander, additional, Neuhaus, Horst, additional, Bisschops, Raf, additional, Schoon, Erik J, additional, de With, Peter H, additional, and Bergman, Jacques J, additional

Published
2019
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35. Optical diagnosis of colorectal polyps with Blue Light Imaging using a new international classification

Author

Subramaniam, Sharmila, primary, Hayee, Bu, additional, Aepli, Patrick, additional, Schoon, Erik, additional, Stefanovic, Milan, additional, Kandiah, Kesavan, additional, Thayalasekaran, Sreedhari, additional, Alkandari, Asma, additional, Bassett, Paul, additional, Coron, Emmanuel, additional, Pech, Oliver, additional, Hassan, Cesare, additional, Neumann, Helmut, additional, Bisschops, Raf, additional, Repici, Alessandro, additional, and Bhandari, Pradeep, additional

Published
2019
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37. Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

Author

Heinrichs, Sophie K. M., Hess, Timo, Becker, Jessica, Hamann, Lutz, Vashist, Yogesh K., Butterbach, Katja, Schmidt, Thomas, Alakus, Hakan, Krasniuk, Iurii, Hoeblinger, Aksana, Lingohr, Philipp, Ludwig, Monika, Hagel, Alexander F., Schildberg, Claus W., Veits, Lothar, Gyvyte, Ugne, Weise, Katharina, Schueller, Vitalia, Boehmer, Anne C., Schroeder, Julia, Gehlen, Jan, Kreuser, Nicole, Hofer, Sebastian, Lang, Hauke, Lordick, Florian, Malfertheiner, Peter, Moehler, Markus, Pech, Oliver, Vassos, Nikolaos, Rodermann, Ernst, Izbicki, Jakob R., Kruschewski, Martin, Ott, Katja, Schumann, Ralf R., Vieth, Michael, Mangold, Elisabeth, Gasenko, Evita, Kupcinskas, Limas, Brenner, Hermann, Grimminger, Peter, Bujanda, Luis, Sopena, Federico, Espinel, Jesus, Thomson, Concha, Perez-Aisa, Angeles, Campo, Rafael, Geijo, Fernando, Collette, Daniela, Bruns, Christiane, Messerle, Katharina, Gockel, Ines, Noethen, Markus M., Lippert, Hans, Ridwelski, Karsten, Lanas, Angel, Keller, Gisela, Knapp, Michael, Leja, Marcis, Kupcinskas, Juozas, Garcia-Gonzalez, Maria A., Venerito, Marino, Schumacher, Johannes, Heinrichs, Sophie K. M., Hess, Timo, Becker, Jessica, Hamann, Lutz, Vashist, Yogesh K., Butterbach, Katja, Schmidt, Thomas, Alakus, Hakan, Krasniuk, Iurii, Hoeblinger, Aksana, Lingohr, Philipp, Ludwig, Monika, Hagel, Alexander F., Schildberg, Claus W., Veits, Lothar, Gyvyte, Ugne, Weise, Katharina, Schueller, Vitalia, Boehmer, Anne C., Schroeder, Julia, Gehlen, Jan, Kreuser, Nicole, Hofer, Sebastian, Lang, Hauke, Lordick, Florian, Malfertheiner, Peter, Moehler, Markus, Pech, Oliver, Vassos, Nikolaos, Rodermann, Ernst, Izbicki, Jakob R., Kruschewski, Martin, Ott, Katja, Schumann, Ralf R., Vieth, Michael, Mangold, Elisabeth, Gasenko, Evita, Kupcinskas, Limas, Brenner, Hermann, Grimminger, Peter, Bujanda, Luis, Sopena, Federico, Espinel, Jesus, Thomson, Concha, Perez-Aisa, Angeles, Campo, Rafael, Geijo, Fernando, Collette, Daniela, Bruns, Christiane, Messerle, Katharina, Gockel, Ines, Noethen, Markus M., Lippert, Hans, Ridwelski, Karsten, Lanas, Angel, Keller, Gisela, Knapp, Michael, Leja, Marcis, Kupcinskas, Juozas, Garcia-Gonzalez, Maria A., Venerito, Marino, and Schumacher, Johannes

Abstract

Genetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine-mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants. On chromosome 5p13 the strongest association was observed at rs6872282 (P = 2.53 x 10(-04)) and on chromosome 8q24 at rs2585176 (P = 1.09 x 10(-09)). On chromosome 5p13 we found cis-eQTL effects with an up-regulation of PTGER4 expression in GC risk allele carrier (P = 9.27 x 10(-11)). On chromosome 8q24 we observed cis-eQTL effects with an upregulation of PSCA expression in GC risk allele carrier (P = 2.17 x 10(-47)). In addition, we found trans-eQTL effects for the same variants on 8q24 with a downregulation of MBOAT7 expression in GC risk allele carrier (P = 3.11 x 10(-09)). In summary, we confirmed and refined the previously reported GC associations at both chromosomal regions. Our data point to shared etiological factors between Asians and Europeans. Furthermore, our data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk-conferring GC pathomechanisms.

Published
2018

38. Evidence for PTGER4 ,PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

Author

Heinrichs, Sophie K. M., primary, Hess, Timo, additional, Becker, Jessica, additional, Hamann, Lutz, additional, Vashist, Yogesh K., additional, Butterbach, Katja, additional, Schmidt, Thomas, additional, Alakus, Hakan, additional, Krasniuk, Iurii, additional, Höblinger, Aksana, additional, Lingohr, Philipp, additional, Ludwig, Monika, additional, Hagel, Alexander F., additional, Schildberg, Claus W., additional, Veits, Lothar, additional, Gyvyte, Ugne, additional, Weise, Katharina, additional, Schüller, Vitalia, additional, Böhmer, Anne C., additional, Schröder, Julia, additional, Gehlen, Jan, additional, Kreuser, Nicole, additional, Hofer, Sebastian, additional, Lang, Hauke, additional, Lordick, Florian, additional, Malfertheiner, Peter, additional, Moehler, Markus, additional, Pech, Oliver, additional, Vassos, Nikolaos, additional, Rodermann, Ernst, additional, Izbicki, Jakob R., additional, Kruschewski, Martin, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Vieth, Michael, additional, Mangold, Elisabeth, additional, Gasenko, Evita, additional, Kupcinskas, Limas, additional, Brenner, Hermann, additional, Grimminger, Peter, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Espinel, Jesús, additional, Thomson, Concha, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Geijo, Fernando, additional, Collette, Daniela, additional, Bruns, Christiane, additional, Messerle, Katharina, additional, Gockel, Ines, additional, Nöthen, Markus M., additional, Lippert, Hans, additional, Ridwelski, Karsten, additional, Lanas, Angel, additional, Keller, Gisela, additional, Knapp, Michael, additional, Leja, Marcis, additional, Kupcinskas, Juozas, additional, García-González, Maria A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2018
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39. Tu2011 - The Argos Project: Evaluation of Results of a Clinicallyinspired Algorithm vs. a Deep Learning Algorithm for the Detection and Delineation of Barrett's Neoplasia

Author

de Groof, Jeroen, primary, van der Putten, Joost, additional, van der Sommen, Fons, additional, Zinger, S., additional, Curvers, Wouter, additional, Bisschops, Raf, additional, Pech, Oliver, additional, Meining, Alexander, additional, Neuhaus, Horst, additional, Schoon, Erik. J., additional, de With, P.H.N., additional, and Bergman, Jacques, additional

Published
2018
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40. 1079 - Blue Light Imaging (Bli) Has an Additional Value to White Light Endoscopy (Wle) in Visualization of Early Barrett's Neoplasia. an International Multicenter Cohort Study

Author

de Groof, Jeroen, primary, Swager, Anne-Fré, additional, Pouw, Roos E., additional, Schoon, Erik. J., additional, Bisschops, Raf, additional, Pech, Oliver, additional, Meining, Alexander, additional, Neuhaus, Horst, additional, Curvers, Wouter, additional, and Bergman, Jacques, additional

Published
2018
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41. Development of quality indicators for endoscopic eradication therapies in Barrett's esophagus: the TREAT-BE (Treatment with Resection and Endoscopic Ablation Techniques for Barrett's Esophagus) Consortium

Author

Wani, Sachin, Muthusamy, V Raman, Shaheen, Nicholas J, Yadlapati, Rena, Wilson, Robert, Abrams, Julian A, Bergman, Jacques, Chak, Amitabh, Chang, Kenneth, Das, Ananya, Dumot, John, Edmundowicz, Steven A, Eisen, Glenn, Falk, Gary W, Fennerty, M Brian, Gerson, Lauren, Ginsberg, Gregory G, Grande, David, Hall, Matt, Harnke, Ben, Inadomi, John, Jankowski, Janusz, Lightdale, Charles J, Makker, Jitin, Odze, Robert D, Pech, Oliver, Sampliner, Richard E, Spechler, Stuart, Triadafilopoulos, George, Wallace, Michael B, Wang, Kenneth, Waxman, Irving, Komanduri, Srinadh, Wani, Sachin, Muthusamy, V Raman, Shaheen, Nicholas J, Yadlapati, Rena, Wilson, Robert, Abrams, Julian A, Bergman, Jacques, Chak, Amitabh, Chang, Kenneth, Das, Ananya, Dumot, John, Edmundowicz, Steven A, Eisen, Glenn, Falk, Gary W, Fennerty, M Brian, Gerson, Lauren, Ginsberg, Gregory G, Grande, David, Hall, Matt, Harnke, Ben, Inadomi, John, Jankowski, Janusz, Lightdale, Charles J, Makker, Jitin, Odze, Robert D, Pech, Oliver, Sampliner, Richard E, Spechler, Stuart, Triadafilopoulos, George, Wallace, Michael B, Wang, Kenneth, Waxman, Irving, and Komanduri, Srinadh

Published
2017

42. Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus

Author

Gharahkhani, Puya, Fitzgerald, Rebecca C., Vaughan, Thomas L., Tomlinson, Ian, Gockel, Ines, Palles, Claire, Buas, Matthew F., May, Andrea, Gerges, Christian, Anders, Mario, Becker, Jessica, Kreuser, Nicole, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Manner, Hendrik, Schmidt, Claudia, Hess, Timo, Bohmer, Anne C., Izbicki, Jakob R., Holscher, Arnulf H., Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Hackelsberger, Andreas, Mayershofer, Rupert, Pech, Oliver, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismuller, Josef, Nothen, Markus M., Attwood, Stephen, Barr, Hugh, Chegwidden, Laura, deCaestecker, John, Harrison, Rebecca, Love, Sharon B., MacDonald, David, Moayyedi, Paul, Prenen, Hans, Watson, RG Peter, Iyer, Prasad G., Anderson, Lesley A., Bernstein, Leslie, Chow, Wong-Ho, Hardie, Laura J., Lagergren, Jesper, Liu, Geoffrey, Risch, Harvey A., Wu, Anna H., Ye, Weimin, Bird, Nigel C., Shaheen, Nicholas J., Gammon, Marilie D., Corley, Douglas A., Caldas, Carlos, Moebus, Susanne, Knapp, Michael, Peters, Wilbert H. M., Neuhaus, Horst, Rosch, Thomas, Ell, Christian, MacGregor, Stuart, Pharoah, Paul, Whiteman, David C., Jankowski, Janusz, Schumacher, Johannes, Gharahkhani, Puya, Fitzgerald, Rebecca C., Vaughan, Thomas L., Tomlinson, Ian, Gockel, Ines, Palles, Claire, Buas, Matthew F., May, Andrea, Gerges, Christian, Anders, Mario, Becker, Jessica, Kreuser, Nicole, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Manner, Hendrik, Schmidt, Claudia, Hess, Timo, Bohmer, Anne C., Izbicki, Jakob R., Holscher, Arnulf H., Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Hackelsberger, Andreas, Mayershofer, Rupert, Pech, Oliver, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismuller, Josef, Nothen, Markus M., Attwood, Stephen, Barr, Hugh, Chegwidden, Laura, deCaestecker, John, Harrison, Rebecca, Love, Sharon B., MacDonald, David, Moayyedi, Paul, Prenen, Hans, Watson, RG Peter, Iyer, Prasad G., Anderson, Lesley A., Bernstein, Leslie, Chow, Wong-Ho, Hardie, Laura J., Lagergren, Jesper, Liu, Geoffrey, Risch, Harvey A., Wu, Anna H., Ye, Weimin, Bird, Nigel C., Shaheen, Nicholas J., Gammon, Marilie D., Corley, Douglas A., Caldas, Carlos, Moebus, Susanne, Knapp, Michael, Peters, Wilbert H. M., Neuhaus, Horst, Rosch, Thomas, Ell, Christian, MacGregor, Stuart, Pharoah, Paul, Whiteman, David C., Jankowski, Janusz, and Schumacher, Johannes

Abstract

SUMMARY Background: Esophageal adenocarcinoma (EA) represents one of the fastest rising oncological diseases in western countries. Barrett’s Esophagus (BE) is the premalignant precursor of EA. However, only a subset of BE patients develop EA, which complicates the clinical management in the absence of valid predictors. Methods: Within an international consortium of groups involved in the genetics of BE/EA, we performed the first meta-analysis of all genome-wide association studies (GWAS) available (>10,000 BE/EA patients, >17,000 controls, all of European descent). The entire GWAS-data set was also analyzed using bioinformatics approaches in order to identify pathophysiologically relevant cellular pathways. Findings: We identified nine new disease loci for BE/EA (P<5×10-8) and thereby doubled the number of known risk loci. The strongest new risk locus implicates CFTR as BE/EA risk gene. Mutations in CFTR cause cystic fibrosis (CF), the most common recessive disorder in Europeans. Gastroesophageal reflux (GER) belongs to the phenotypic CF-spectrum and represents the main risk factor for BE/EA. Thus, the CFTR locus may trigger a common GER-mediated pathophysiology. The strongest disease pathways identified (P<10-6) belong to muscle cell differentiation and to mesenchyme development/differentiation, which fit with current pathophysiological BE/EA concepts. Furthermore, for the first time we identified an EA-specific association (P=1·6×10-8) near HTR3C/ABCC5 which is independent of BE development (P=0·45). Interpretation: The identified disease loci and pathways reveal new insights into the etiology of BE and EA. Furthermore, the EA-specific association at HTR3C/ABCC5 may constitute a novel genetic marker for the prediction of transition from BE to EA. Funding: US National Cancer Institute, US National Institutes of Health, National Health and Medical Research Council of Australia, Swedish Cancer Society, Medical Research Council of UK, Cambridge NIHR biomedical researc

Published
2017

43. Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis

Author

Gharahkhani, Puya, Fitzgerald, Rebecca C, Vaughan, Thomas L, Palles, Claire, Gockel, Ines, Tomlinson, Ian, Buas, Matthew F, May, Andrea, Gerges, Christian, Anders, Mario, Becker, Jessica, Kreuser, Nicole, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Manner, Hendrik, Schmidt, Claudia, Hess, Timo, Böhmer, Anne C, Izbicki, Jakob R, Hölscher, Arnulf H, Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Hackelsberger, Andreas, Mayershofer, Rupert, Pech, Oliver, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismüller, Josef, Nöthen, Markus M, Barrett's And Esophageal Adenocarcinoma Consortium (BEACON), Esophageal Adenocarcinoma GenEtics Consortium (EAGLE), Wellcome Trust Case Control Consortium 2 (WTCCC2), Attwood, Stephen, Barr, Hugh, Chegwidden, Laura, De Caestecker, John, Harrison, Rebecca, Love, Sharon B, MacDonald, David, Moayyedi, Paul, Prenen, Hans, Watson, RG Peter, Iyer, Prasad G, Anderson, Lesley A, Bernstein, Leslie, Chow, Wong-Ho, Hardie, Laura J, Lagergren, Jesper, Liu, Geoffrey, Risch, Harvey A, Wu, Anna H, Ye, Weimin, Bird, Nigel C, Shaheen, Nicholas J, Gammon, Marilie D, Corley, Douglas A, Caldas, Carlos, Moebus, Susanne, Knapp, Michael, Peters, Wilbert HM, Neuhaus, Horst, Rösch, Thomas, Ell, Christian, MacGregor, Stuart, Pharoah, Paul, Whiteman, David C, Jankowski, Janusz, Schumacher, Johannes, Fitzgerald, Rebecca [0000-0002-3434-3568], Caldas, Carlos [0000-0003-3547-1489], Pharoah, Paul [0000-0001-8494-732X], and Apollo - University of Cambridge Repository

Subjects
Risk, Barrett Esophagus, Esophageal Neoplasms, Humans, Adenocarcinoma, Polymorphism, Single Nucleotide, digestive system diseases, Genome-Wide Association Study
Abstract

BACKGROUND: Oesophageal adenocarcinoma represents one of the fastest rising cancers in high-income countries. Barrett's oesophagus is the premalignant precursor of oesophageal adenocarcinoma. However, only a few patients with Barrett's oesophagus develop adenocarcinoma, which complicates clinical management in the absence of valid predictors. Within an international consortium investigating the genetics of Barrett's oesophagus and oesophageal adenocarcinoma, we aimed to identify novel genetic risk variants for the development of Barrett's oesophagus and oesophageal adenocarcinoma. METHODS: We did a meta-analysis of all genome-wide association studies of Barrett's oesophagus and oesophageal adenocarcinoma available in PubMed up to Feb 29, 2016; all patients were of European ancestry and disease was confirmed histopathologically. All participants were from four separate studies within Europe, North America, and Australia and were genotyped on high-density single nucleotide polymorphism (SNP) arrays. Meta-analysis was done with a fixed-effects inverse variance-weighting approach and with a standard genome-wide significance threshold (p

Published
2016

44. The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk

Author

Becker, Jessica, May, Andrea, Gerges, Christian, Anders, Mario, Schmidt, Claudia, Veits, Lothar, Noder, Tania, Mayershofer, Rupert, Kreuser, Nicole, Manner, Hendrik, Venerito, Marino, Hofer, Jan-Hinnerk, Lyros, Orestis, Ahlbrand, Constantin J., Arras, Michael, Hofer, Sebastian, Heinrichs, Sophie K. M., Weise, Katharina, Hess, Timo, Boehmer, Anne C., Kosiol, Nils, Kiesslich, Ralf, Izbicki, Jakob R., Hoelscher, Arnulf H., Bollschweiler, Elfriede, Malfertheiner, Peter, Lang, Hauke, Moehler, Markus, Lorenz, Dietmar, Ott, Katja, Schmidt, Thomas, Noethen, Markus M., Hackelsberger, Andreas, Schumacher, Brigitte, Pech, Oliver, Vashist, Yogesh, Vieth, Michael, Weismueller, Josef, Knapp, Michael, Neuhaus, Horst, Roesch, Thomas, Ell, Christian, Gockel, Ines, Schumacher, Johannes, Becker, Jessica, May, Andrea, Gerges, Christian, Anders, Mario, Schmidt, Claudia, Veits, Lothar, Noder, Tania, Mayershofer, Rupert, Kreuser, Nicole, Manner, Hendrik, Venerito, Marino, Hofer, Jan-Hinnerk, Lyros, Orestis, Ahlbrand, Constantin J., Arras, Michael, Hofer, Sebastian, Heinrichs, Sophie K. M., Weise, Katharina, Hess, Timo, Boehmer, Anne C., Kosiol, Nils, Kiesslich, Ralf, Izbicki, Jakob R., Hoelscher, Arnulf H., Bollschweiler, Elfriede, Malfertheiner, Peter, Lang, Hauke, Moehler, Markus, Lorenz, Dietmar, Ott, Katja, Schmidt, Thomas, Noethen, Markus M., Hackelsberger, Andreas, Schumacher, Brigitte, Pech, Oliver, Vashist, Yogesh, Vieth, Michael, Weismueller, Josef, Knapp, Michael, Neuhaus, Horst, Roesch, Thomas, Ell, Christian, Gockel, Ines, and Schumacher, Johannes

Abstract

Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE/EAC sequence. In contrast, rs3784262 at ALDH1A2 was highly significantly associated with BE, but showed no association with EAC. Our data do not provide evidence that the ALDH1A2 locus confers equal risk in early and late stages of BE/EAC sequence.

Published
2016

45. Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus

Author

Gharahkhani, Puya, Fitzgerald, Rebecca C., Vaughan, Thomas L., Tomlinson, Ian, Gockel, Ines, Palles, Claire, Buas, Matthew F., May, Andrea, Gerges, Christian, Anders, Mario, Becker, Jessica, Kreuser, Nicole, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Manner, Hendrik, Schmidt, Claudia, Hess, Timo, Bohmer, Anne C., Izbicki, Jakob R., Holscher, Arnulf H., Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Hackelsberger, Andreas, Mayershofer, Rupert, Pech, Oliver, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismuller, Josef, Nothen, Markus M., Attwood, Stephen, Barr, Hugh, Chegwidden, Laura, deCaestecker, John, Harrison, Rebecca, Love, Sharon B., MacDonald, David, Moayyedi, Paul, Prenen, Hans, Watson, RG Peter, Iyer, Prasad G., Anderson, Lesley A., Bernstein, Leslie, Chow, Wong-Ho, Hardie, Laura J., Lagergren, Jesper, Liu, Geoffrey, Risch, Harvey A., Wu, Anna H., Ye, Weimin, Bird, Nigel C., Shaheen, Nicholas J., Gammon, Marilie D., Corley, Douglas A., Caldas, Carlos, Moebus, Susanne, Knapp, Michael, Peters, Wilbert H. M., Neuhaus, Horst, Rosch, Thomas, Ell, Christian, MacGregor, Stuart, Pharoah, Paul, Whiteman, David C., Jankowski, Janusz, Schumacher, Johannes, Gharahkhani, Puya, Fitzgerald, Rebecca C., Vaughan, Thomas L., Tomlinson, Ian, Gockel, Ines, Palles, Claire, Buas, Matthew F., May, Andrea, Gerges, Christian, Anders, Mario, Becker, Jessica, Kreuser, Nicole, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Manner, Hendrik, Schmidt, Claudia, Hess, Timo, Bohmer, Anne C., Izbicki, Jakob R., Holscher, Arnulf H., Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Hackelsberger, Andreas, Mayershofer, Rupert, Pech, Oliver, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismuller, Josef, Nothen, Markus M., Attwood, Stephen, Barr, Hugh, Chegwidden, Laura, deCaestecker, John, Harrison, Rebecca, Love, Sharon B., MacDonald, David, Moayyedi, Paul, Prenen, Hans, Watson, RG Peter, Iyer, Prasad G., Anderson, Lesley A., Bernstein, Leslie, Chow, Wong-Ho, Hardie, Laura J., Lagergren, Jesper, Liu, Geoffrey, Risch, Harvey A., Wu, Anna H., Ye, Weimin, Bird, Nigel C., Shaheen, Nicholas J., Gammon, Marilie D., Corley, Douglas A., Caldas, Carlos, Moebus, Susanne, Knapp, Michael, Peters, Wilbert H. M., Neuhaus, Horst, Rosch, Thomas, Ell, Christian, MacGregor, Stuart, Pharoah, Paul, Whiteman, David C., Jankowski, Janusz, and Schumacher, Johannes

Abstract

SUMMARY Background: Esophageal adenocarcinoma (EA) represents one of the fastest rising oncological diseases in western countries. Barrett’s Esophagus (BE) is the premalignant precursor of EA. However, only a subset of BE patients develop EA, which complicates the clinical management in the absence of valid predictors. Methods: Within an international consortium of groups involved in the genetics of BE/EA, we performed the first meta-analysis of all genome-wide association studies (GWAS) available (>10,000 BE/EA patients, >17,000 controls, all of European descent). The entire GWAS-data set was also analyzed using bioinformatics approaches in order to identify pathophysiologically relevant cellular pathways. Findings: We identified nine new disease loci for BE/EA (P<5×10-8) and thereby doubled the number of known risk loci. The strongest new risk locus implicates CFTR as BE/EA risk gene. Mutations in CFTR cause cystic fibrosis (CF), the most common recessive disorder in Europeans. Gastroesophageal reflux (GER) belongs to the phenotypic CF-spectrum and represents the main risk factor for BE/EA. Thus, the CFTR locus may trigger a common GER-mediated pathophysiology. The strongest disease pathways identified (P<10-6) belong to muscle cell differentiation and to mesenchyme development/differentiation, which fit with current pathophysiological BE/EA concepts. Furthermore, for the first time we identified an EA-specific association (P=1·6×10-8) near HTR3C/ABCC5 which is independent of BE development (P=0·45). Interpretation: The identified disease loci and pathways reveal new insights into the etiology of BE and EA. Furthermore, the EA-specific association at HTR3C/ABCC5 may constitute a novel genetic marker for the prediction of transition from BE to EA. Funding: US National Cancer Institute, US National Institutes of Health, National Health and Medical Research Council of Australia, Swedish Cancer Society, Medical Research Council of UK, Cambridge NIHR biomedical researc

Published
2016

46. Performance measures for upper gastrointestinal endoscopy: A European Society of Gastrointestinal Endoscopy quality improvement initiative

Author

Bisschops, Raf, primary, Areia, Miguel, additional, Coron, Emmanuel, additional, Dobru, Daniela, additional, Kaskas, Bernd, additional, Kuvaev, Roman, additional, Pech, Oliver, additional, Ragunath, Krish, additional, Weusten, Bas, additional, Familiari, Pietro, additional, Domagk, Dirk, additional, Valori, Roland, additional, Kaminski, Michal F, additional, Spada, Cristiano, additional, Bretthauer, Michael, additional, Bennett, Cathy, additional, Senore, Carlo, additional, Dinis‐Ribeiro, Mário, additional, and Rutter, Matthew D, additional

Published
2016
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47. The Barrett‐associated variants atGDF 7andTBX 5also increase esophageal adenocarcinoma risk

Author

Becker, Jessica, primary, May, Andrea, additional, Gerges, Christian, additional, Anders, Mario, additional, Schmidt, Claudia, additional, Veits, Lothar, additional, Noder, Tania, additional, Mayershofer, Rupert, additional, Kreuser, Nicole, additional, Manner, Hendrik, additional, Venerito, Marino, additional, Hofer, Jan‐Hinnerk, additional, Lyros, Orestis, additional, Ahlbrand, Constantin J., additional, Arras, Michael, additional, Hofer, Sebastian, additional, Heinrichs, Sophie K. M., additional, Weise, Katharina, additional, Hess, Timo, additional, Böhmer, Anne C., additional, Kosiol, Nils, additional, Kiesslich, Ralf, additional, Izbicki, Jakob R., additional, Hölscher, Arnulf H., additional, Bollschweiler, Elfriede, additional, Malfertheiner, Peter, additional, Lang, Hauke, additional, Moehler, Markus, additional, Lorenz, Dietmar, additional, Ott, Katja, additional, Schmidt, Thomas, additional, Nöthen, Markus M., additional, Hackelsberger, Andreas, additional, Schumacher, Brigitte, additional, Pech, Oliver, additional, Vashist, Yogesh, additional, Vieth, Michael, additional, Weismüller, Josef, additional, Knapp, Michael, additional, Neuhaus, Horst, additional, Rösch, Thomas, additional, Ell, Christian, additional, Gockel, Ines, additional, and Schumacher, Johannes, additional

Published
2016
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48. Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma

Author

Becker, Jessica, May, Andrea, Gerges, Christian, Anders, Mario, Veits, Lothar, Weise, Katharina, Czamara, Darina, Lyros, Orestis, Manner, Hendrik, Terheggen, Grischa, Venerito, Marino, Noder, Tania, Mayershofer, Rupert, Hofer, Jan-Hinnerk, Karch, Hans-Werner, Ahlbrand, Constantin J., Arras, Michael, Hofer, Sebastian, Mangold, Elisabeth, Heilmann-Heimbach, Stefanie, Heinrichs, Sophie K. M., Hess, Timo, Kiesslich, Ralf, Izbicki, Jakob R., Hoelscher, Arnulf H., Bollschweiler, Elfriede, Malfertheiner, Peter, Lang, Hauke, Moehler, Markus, Lorenz, Dietmar, Mueller-Myhsok, Bertram, Ott, Katja, Schmidt, Thomas, Whiteman, David C., Vaughan, Thomas L., Noethen, Markus M., Hackelsberger, Andreas, Schumacher, Brigitte, Pech, Oliver, Vashist, Yogesh, Vieth, Michael, Weismueller, Josef, Neuhaus, Horst, Roesch, Thomas, Ell, Christian, Gockel, Ines, Schumacher, Johannes, Becker, Jessica, May, Andrea, Gerges, Christian, Anders, Mario, Veits, Lothar, Weise, Katharina, Czamara, Darina, Lyros, Orestis, Manner, Hendrik, Terheggen, Grischa, Venerito, Marino, Noder, Tania, Mayershofer, Rupert, Hofer, Jan-Hinnerk, Karch, Hans-Werner, Ahlbrand, Constantin J., Arras, Michael, Hofer, Sebastian, Mangold, Elisabeth, Heilmann-Heimbach, Stefanie, Heinrichs, Sophie K. M., Hess, Timo, Kiesslich, Ralf, Izbicki, Jakob R., Hoelscher, Arnulf H., Bollschweiler, Elfriede, Malfertheiner, Peter, Lang, Hauke, Moehler, Markus, Lorenz, Dietmar, Mueller-Myhsok, Bertram, Ott, Katja, Schmidt, Thomas, Whiteman, David C., Vaughan, Thomas L., Noethen, Markus M., Hackelsberger, Andreas, Schumacher, Brigitte, Pech, Oliver, Vashist, Yogesh, Vieth, Michael, Weismueller, Josef, Neuhaus, Horst, Roesch, Thomas, Ell, Christian, Gockel, Ines, and Schumacher, Johannes

Abstract

The Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) recently performed a genome-wide association study (GWAS) on esophageal adenocarcinoma (EAC) and Barrett's esophagus. They identified genome-wide significant association for variants at three genes, namely CRTC1, FOXP1, and BARX1. Furthermore, they replicated an association at the FOXF1 gene that has been previously found in a GWAS on Barrett's esophagus. We aimed at further replicating the association at these and other loci that showed suggestive association with P< 10(-4) in the BEACON sample. In total, we tested 88 SNPs in an independent sample consisting of 1065 EAC cases and 1019 controls of German descent. We could replicate the association at FOXP1, BARX1, and FOXF1 with nominal significance and thereby confirm that genetic variants at these genes confer EAC risk. In addition, we found association of variants near the genes XRCC2 and GATA6 that were strongly (P<10(-5)) although not genome-wide significantly associated with the BEACON GWAS. Therefore, both variants and corresponding genes represent promising candidates for future EAC association studies on independent samples.

Published
2015

49. BOB CAT: a Large-Scale Review and Delphi Consensus for Management of Barrett’s Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia

Author

Bennett, Cathy, Moayyedi, Paul, Corley, Douglas A, DeCaestecker, John, Falck-Ytter, Yngve, Falk, Gary, Vakil, Nimish, Sanders, Scott, Vieth, Michael, Inadomi, John, Aldulaimi, David, Ho, Khek-Yu, Odze, Robert, Meltzer, Stephen J, Quigley, Eamonn, Gittens, Stuart, Watson, Peter, Zaninotto, Giovanni, Iyer, Prasad G, Alexandre, Leo, Ang, Yeng, Callaghan, James, Harrison, Rebecca, Singh, Rajvinder, Bhandari, Pradeep, Bisschops, Raf, Geramizadeh, Bita, Kaye, Philip, Krishnadath, Sheila, Fennerty, M Brian, Manner, Hendrik, Nason, Katie S, Pech, Oliver, Konda, Vani, Ragunath, Krish, Rahman, Imdadur, Romero, Yvonne, Sampliner, Richard, Siersema, Peter D, Tack, Jan, Tham, Tony C K, Trudgill, Nigel, Weinberg, David S, Wang, Jean, Wang, Kenneth, Wong, Jennie Y Y, Attwood, Stephen, Malfertheiner, Peter, MacDonald, David, Barr, Hugh, Ferguson, Mark K, Jankowski, Janusz, Bennett, Cathy, Moayyedi, Paul, Corley, Douglas A, DeCaestecker, John, Falck-Ytter, Yngve, Falk, Gary, Vakil, Nimish, Sanders, Scott, Vieth, Michael, Inadomi, John, Aldulaimi, David, Ho, Khek-Yu, Odze, Robert, Meltzer, Stephen J, Quigley, Eamonn, Gittens, Stuart, Watson, Peter, Zaninotto, Giovanni, Iyer, Prasad G, Alexandre, Leo, Ang, Yeng, Callaghan, James, Harrison, Rebecca, Singh, Rajvinder, Bhandari, Pradeep, Bisschops, Raf, Geramizadeh, Bita, Kaye, Philip, Krishnadath, Sheila, Fennerty, M Brian, Manner, Hendrik, Nason, Katie S, Pech, Oliver, Konda, Vani, Ragunath, Krish, Rahman, Imdadur, Romero, Yvonne, Sampliner, Richard, Siersema, Peter D, Tack, Jan, Tham, Tony C K, Trudgill, Nigel, Weinberg, David S, Wang, Jean, Wang, Kenneth, Wong, Jennie Y Y, Attwood, Stephen, Malfertheiner, Peter, MacDonald, David, Barr, Hugh, Ferguson, Mark K, and Jankowski, Janusz

Abstract

OBJECTIVES: Barrett’s esophagus (BE) is a common premalignant lesion for which surveillance is recommended. This strategy is limited by considerable variations in clinical practice. We conducted an international, multidisciplinary, systematic search and evidence-based review of BE and provided consensus recommendations for clinical use in patients with nondysplastic, indefinite, and low-grade dysplasia (LGD). METHODS: We defined the scope, proposed statements, and searched electronic databases, yielding 20,558 publications that were screened, selected online, and formed the evidence base. We used a Delphi consensus process, with an 80% agreement threshold, using GRADE (Grading of Recommendations Assessment, Development and Evaluation) to categorize the quality of evidence and strength of recommendations. RESULTS: In total, 80% of respondents agreed with 55 of 127 statements in the final voting rounds. Population endoscopic screening is not recommended and screening should target only very high-risk cases of males aged over 60 years with chronic uncontrolled reflux. A new international definition of BE was agreed upon. For any degree of dysplasia, at least two specialist gastrointestinal (GI) pathologists are required. Risk factors for cancer include male gender, length of BE, and central obesity. Endoscopic resection should be used for visible, nodular areas. Surveillance is not recommended for <5 years of life expectancy. Management strategies for indefinite dysplasia (IND) and LGD were identified, including a de-escalation strategy for lower-risk patients and escalation to intervention with follow-up for higher-risk patients. CONCLUSIONS: In this uniquely large consensus process in gastroenterology, we made key clinical recommendations for the escalation/de-escalation of BE in clinical practice. We made strong recommendations for the prioritization of future research.

Published
2015

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