255 results on '"Peitzman, Andrew B."'
Search Results
2. 2023 WSES guidelines for the prevention, detection, and management of iatrogenic urinary tract injuries (IUTIs) during emergency digestive surgery
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de’Angelis, Nicola, Schena, Carlo Alberto, Marchegiani, Francesco, Reitano, Elisa, De Simone, Belinda, Wong, Geoffrey Yuet Mun, Martínez-Pérez, Aleix, Abu-Zidan, Fikri M., Agnoletti, Vanni, Aisoni, Filippo, Ammendola, Michele, Ansaloni, Luca, Bala, Miklosh, Biffl, Walter, Ceccarelli, Graziano, Ceresoli, Marco, Chiara, Osvaldo, Chiarugi, Massimo, Cimbanassi, Stefania, Coccolini, Federico, Coimbra, Raul, Di Saverio, Salomone, Diana, Michele, Dioguardi Burgio, Marco, Fraga, Gustavo, Gavriilidis, Paschalis, Gurrado, Angela, Inchingolo, Riccardo, Ingels, Alexandre, Ivatury, Rao, Kashuk, Jeffry L., Khan, Jim, Kirkpatrick, Andrew W., Kim, Fernando J., Kluger, Yoram, Lakkis, Zaher, Leppäniemi, Ari, Maier, Ronald V., Memeo, Riccardo, Moore, Ernest E., Ordoñez, Carlos A., Peitzman, Andrew B., Pellino, Gianluca, Picetti, Edoardo, Pikoulis, Manos, Pisano, Michele, Podda, Mauro, Romeo, Oreste, Rosa, Fausto, Tan, Edward, Ten Broek, Richard P., Testini, Mario, Tian Wei Cheng, Brian Anthony, Weber, Dieter, Sacco, Emilio, Sartelli, Massimo, Tonsi, Alfredo, Dal Moro, Fabrizio, and Catena, Fausto
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- 2023
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3. Prediction of morbidity and mortality after early cholecystectomy for acute calculous cholecystitis: results of the S.P.Ri.M.A.C.C. study
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Fugazzola, Paola, Cobianchi, Lorenzo, Di Martino, Marcello, Tomasoni, Matteo, Dal Mas, Francesca, Abu-Zidan, Fikri M., Agnoletti, Vanni, Ceresoli, Marco, Coccolini, Federico, Di Saverio, Salomone, Dominioni, Tommaso, Farè, Camilla Nikita, Frassini, Simone, Gambini, Giulia, Leppäniemi, Ari, Maestri, Marcello, Martín-Pérez, Elena, Moore, Ernest E., Musella, Valeria, Peitzman, Andrew B., de la Hoz Rodríguez, Ángela, Sargenti, Benedetta, Sartelli, Massimo, Viganò, Jacopo, Anderloni, Andrea, Biffl, Walter, Catena, Fausto, and Ansaloni, Luca
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- 2023
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4. Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group
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ten Broek, Richard PG, Krielen, Pepijn, Di Saverio, Salomone, Coccolini, Federico, Biffl, Walter L, Ansaloni, Luca, Velmahos, George C, Sartelli, Massimo, Fraga, Gustavo P, Kelly, Michael D, Moore, Frederick A, Peitzman, Andrew B, Leppaniemi, Ari, Moore, Ernest E, Jeekel, Johannes, Kluger, Yoram, Sugrue, Michael, Balogh, Zsolt J, Bendinelli, Cino, Civil, Ian, Coimbra, Raul, De Moya, Mark, Ferrada, Paula, Inaba, Kenji, Ivatury, Rao, Latifi, Rifat, Kashuk, Jeffry L, Kirkpatrick, Andrew W, Maier, Ron, Rizoli, Sandro, Sakakushev, Boris, Scalea, Thomas, Søreide, Kjetil, Weber, Dieter, Wani, Imtiaz, Abu-Zidan, Fikri M, De’Angelis, Nicola, Piscioneri, Frank, Galante, Joseph M, Catena, Fausto, and van Goor, Harry
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Patient Safety ,Prevention ,Digestive Diseases ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,7.3 Management and decision making ,6.4 Surgery ,Management of diseases and conditions ,Oral and gastrointestinal ,Disease Management ,General Surgery ,Guidelines as Topic ,Humans ,Intestinal Obstruction ,Tissue Adhesions ,Treatment Outcome ,Small bowel obstruction ,Adhesions ,Surgery ,Laparoscopy ,Laparotomy - Abstract
BackgroundAdhesive small bowel obstruction (ASBO) is a common surgical emergency, causing high morbidity and even some mortality. The adhesions causing such bowel obstructions are typically the footprints of previous abdominal surgical procedures. The present paper presents a revised version of the Bologna guidelines to evidence-based diagnosis and treatment of ASBO. The working group has added paragraphs on prevention of ASBO and special patient groups.MethodsThe guideline was written under the auspices of the World Society of Emergency Surgery by the ASBO working group. A systematic literature search was performed prior to the update of the guidelines to identify relevant new papers on epidemiology, diagnosis, and treatment of ASBO. Literature was critically appraised according to an evidence-based guideline development method. Final recommendations were approved by the workgroup, taking into account the level of evidence of the conclusion.RecommendationsAdhesion formation might be reduced by minimally invasive surgical techniques and the use of adhesion barriers. Non-operative treatment is effective in most patients with ASBO. Contraindications for non-operative treatment include peritonitis, strangulation, and ischemia. When the adhesive etiology of obstruction is unsure, or when contraindications for non-operative management might be present, CT is the diagnostic technique of choice. The principles of non-operative treatment are nil per os, naso-gastric, or long-tube decompression, and intravenous supplementation with fluids and electrolytes. When operative treatment is required, a laparoscopic approach may be beneficial for selected cases of simple ASBO.Younger patients have a higher lifetime risk for recurrent ASBO and might therefore benefit from application of adhesion barriers as both primary and secondary prevention.DiscussionThis guideline presents recommendations that can be used by surgeons who treat patients with ASBO. Scientific evidence for some aspects of ASBO management is scarce, in particular aspects relating to special patient groups. Results of a randomized trial of laparoscopic versus open surgery for ASBO are awaited.
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- 2018
5. Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery
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Bala, Miklosh, Catena, Fausto, Kashuk, Jeffry, De Simone, Belinda, Gomes, Carlos Augusto, Weber, Dieter, Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Abu-Zidan, Fikri M., Picetti, Edoardo, Ansaloni, Luca, Augustin, Goran, Biffl, Walter L., Ceresoli, Marco, Chiara, Osvaldo, Chiarugi, Massimo, Coimbra, Raul, Cui, Yunfeng, Damaskos, Dimitris, Di Saverio, Salomone, Galante, Joseph M., Khokha, Vladimir, Kirkpatrick, Andrew W., Inaba, Kenji, Leppäniemi, Ari, Litvin, Andrey, Peitzman, Andrew B., Shelat, Vishal G., Sugrue, Michael, Tolonen, Matti, Rizoli, Sandro, Sall, Ibrahima, Beka, Solomon G., Di Carlo, Isidoro, Ten Broek, Richard, Mircea, Chirika, Tebala, Giovanni, Pisano, Michele, van Goor, Harry, Maier, Ronald V., Jeekel, Hans, Civil, Ian, Hecker, Andreas, Tan, Edward, Soreide, Kjetil, Lee, Matthew J., Wani, Imtiaz, Bonavina, Luigi, Malangoni, Mark A., Koike, Kaoru, Velmahos, George C., Fraga, Gustavo P., Fette, Andreas, de’Angelis, Nicola, Balogh, Zsolt J., Scalea, Thomas M., Sganga, Gabriele, Kelly, Michael D., Khan, Jim, Stahel, Philip F., and Moore, Ernest E.
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- 2022
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6. WSES guidelines on blunt and penetrating bowel injury: diagnosis, investigations, and treatment
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Smyth, Luke, Bendinelli, Cino, Lee, Nicholas, Reeds, Matthew G., Loh, Eu Jhin, Amico, Francesco, Balogh, Zsolt J., Di Saverio, Salomone, Weber, Dieter, ten Broek, Richard Peter, Abu-Zidan, Fikri M., Campanelli, Giampiero, Beka, Solomon Gurmu, Chiarugi, Massimo, Shelat, Vishal G., Tan, Edward, Moore, Ernest, Bonavina, Luigi, Latifi, Rifat, Hecker, Andreas, Khan, Jim, Coimbra, Raul, Tebala, Giovanni D., Søreide, Kjetil, Wani, Imtiaz, Inaba, Kenji, Kirkpatrick, Andrew W., Koike, Kaoru, Sganga, Gabriele, Biffl, Walter L., Chiara, Osvaldo, Scalea, Thomas M., Fraga, Gustavo P., Peitzman, Andrew B., and Catena, Fausto
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- 2022
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7. The WSES/SICG/ACOI/SICUT/AcEMC/SIFIPAC guidelines for diagnosis and treatment of acute left colonic diverticulitis in the elderly
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Fugazzola, Paola, Ceresoli, Marco, Coccolini, Federico, Gabrielli, Francesco, Puzziello, Alessandro, Monzani, Fabio, Amato, Bruno, Sganga, Gabriele, Sartelli, Massimo, Menichetti, Francesco, Puglisi, Gabriele Adolfo, Tartaglia, Dario, Carcoforo, Paolo, Avenia, Nicola, Kluger, Yoram, Paolillo, Ciro, Zago, Mauro, Leppäniemi, Ari, Tomasoni, Matteo, Cobianchi, Lorenzo, Dal Mas, Francesca, Improta, Mario, Moore, Ernest E., Peitzman, Andrew B., Sugrue, Michael, Agnoletti, Vanni, Fraga, Gustavo P., Weber, Dieter G., Damaskos, Dimitrios, Abu-Zidan, Fikri M., Wani, Imtiaz, Kirkpatrick, Andrew W., Pikoulis, Manos, Pararas, Nikolaos, Tan, Edward, Broek, Richard Ten, Maier, Ronald V., Davies, R. Justin, Kashuk, Jeffry, Shelat, Vishal G., Mefire, Alain Chicom, Augustin, Goran, Magnone, Stefano, Poiasina, Elia, De Simone, Belinda, Chiarugi, Massimo, Biffl, Walt, Baiocchi, Gian Luca, Catena, Fausto, and Ansaloni, Luca
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- 2022
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8. WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections
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Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Agastra, Ervis, Abu-Zidan, Fikri M., Abbas, Ashraf El Sayed, Ansaloni, Luca, Adesunkanmi, Abdulrashid Kayode, Augustin, Goran, Bala, Miklosh, Baraket, Oussama, Biffl, Walter L., Ceresoli, Marco, Cerutti, Elisabetta, Chiara, Osvaldo, Cicuttin, Enrico, Chiarugi, Massimo, Coimbra, Raul, Corsi, Daniela, Cortese, Francesco, Cui, Yunfeng, Damaskos, Dimitris, de’Angelis, Nicola, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, de Jonge, Stijn W., Di Bella, Stefano, Di Saverio, Salomone, Duane, Therese M., Fugazzola, Paola, Galante, Joseph M., Ghnnam, Wagih, Gkiokas, George, Gomes, Carlos Augusto, Griffiths, Ewen A., Hardcastle, Timothy C., Hecker, Andreas, Herzog, Torsten, Karamarkovic, Aleksandar, Khokha, Vladimir, Kim, Peter K., Kim, Jae Il, Kirkpatrick, Andrew W., Kong, Victor, Koshy, Renol M., Inaba, Kenji, Isik, Arda, Ivatury, Rao, Labricciosa, Francesco M., Lee, Yeong Yeh, Leppäniemi, Ari, Litvin, Andrey, Luppi, Davide, Maier, Ronald V., Marinis, Athanasios, Marwah, Sanjay, Mesina, Cristian, Moore, Ernest E., Moore, Frederick A., Negoi, Ionut, Olaoye, Iyiade, Ordoñez, Carlos A., Ouadii, Mouaqit, Peitzman, Andrew B., Perrone, Gennaro, Pintar, Tadeja, Pipitone, Giuseppe, Podda, Mauro, Raşa, Kemal, Ribeiro, Julival, Rodrigues, Gabriel, Rubio-Perez, Ines, Sall, Ibrahima, Sato, Norio, Sawyer, Robert G., Shelat, Vishal G., Sugrue, Michael, Tarasconi, Antonio, Tolonen, Matti, Viaggi, Bruno, Celotti, Andrea, Casella, Claudio, Pagani, Leonardo, Dhingra, Sameer, Baiocchi, Gian Luca, and Catena, Fausto
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- 2022
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9. Splenic trauma: WSES classification and guidelines for adult and pediatric patients
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Coccolini, Federico, Montori, Giulia, Catena, Fausto, Kluger, Yoram, Biffl, Walter, Moore, Ernest E, Reva, Viktor, Bing, Camilla, Bala, Miklosh, Fugazzola, Paola, Bahouth, Hany, Marzi, Ingo, Velmahos, George, Ivatury, Rao, Soreide, Kjetil, Horer, Tal, ten Broek, Richard, Pereira, Bruno M, Fraga, Gustavo P, Inaba, Kenji, Kashuk, Joseph, Parry, Neil, Masiakos, Peter T, Mylonas, Konstantinos S, Kirkpatrick, Andrew, Abu-Zidan, Fikri, Gomes, Carlos Augusto, Benatti, Simone Vasilij, Naidoo, Noel, Salvetti, Francesco, Maccatrozzo, Stefano, Agnoletti, Vanni, Gamberini, Emiliano, Solaini, Leonardo, Costanzo, Antonio, Celotti, Andrea, Tomasoni, Matteo, Khokha, Vladimir, Arvieux, Catherine, Napolitano, Lena, Handolin, Lauri, Pisano, Michele, Magnone, Stefano, Spain, David A, de Moya, Marc, Davis, Kimberly A, De Angelis, Nicola, Leppaniemi, Ari, Ferrada, Paula, Latifi, Rifat, Navarro, David Costa, Otomo, Yashuiro, Coimbra, Raul, Maier, Ronald V, Moore, Frederick, Rizoli, Sandro, Sakakushev, Boris, Galante, Joseph M, Chiara, Osvaldo, Cimbanassi, Stefania, Mefire, Alain Chichom, Weber, Dieter, Ceresoli, Marco, Peitzman, Andrew B, Wehlie, Liban, Sartelli, Massimo, Di Saverio, Salomone, and Ansaloni, Luca
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Physical Injury - Accidents and Adverse Effects ,Childhood Injury ,Emergency Care ,Patient Safety ,Pediatric ,Hematology ,Injuries and accidents ,Abdominal Injuries ,Adult ,Conservative Treatment ,Guidelines as Topic ,Hemodynamics ,Humans ,Spleen ,Wounds and Injuries ,Trauma ,Classification ,Guidelines ,Embolization ,Surgery ,Non-operative ,Conservative - Abstract
Spleen injuries are among the most frequent trauma-related injuries. At present, they are classified according to the anatomy of the injury. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic derangement, and the associated injuries. The management of splenic trauma patients aims to restore the homeostasis and the normal physiopathology especially considering the modern tools for bleeding management. Thus, the management of splenic trauma should be ultimately multidisciplinary and based on the physiology of the patient, the anatomy of the injury, and the associated lesions. Lastly, as the management of adults and children must be different, children should always be treated in dedicated pediatric trauma centers. In fact, the vast majority of pediatric patients with blunt splenic trauma can be managed non-operatively. This paper presents the World Society of Emergency Surgery (WSES) classification of splenic trauma and the management guidelines.
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- 2017
10. Development and Validation of the Air Medical Prehospital Triage Score for Helicopter Transport of Trauma Patients
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Brown, Joshua B, Gestring, Mark L, Guyette, Francis X, Rosengart, Matthew R, Stassen, Nicole A, Forsythe, Raquel M, Billiar, Timothy R, Peitzman, Andrew B, and Sperry, Jason L
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Adult ,Aged ,Air Ambulances ,Female ,Humans ,Injury Severity Score ,Male ,Middle Aged ,Patient Selection ,Reproducibility of Results ,Retrospective Studies ,Survival Rate ,Triage ,Wounds and Injuries ,Young Adult ,air medical ,emergency medical services ,helicopter ,injury ,prehospital ,scene ,transport ,trauma ,triage ,Medical and Health Sciences ,Surgery ,Clinical sciences - Abstract
ObjectiveThe aim of this study was to develop and internally validate a triage score that can identify trauma patients at the scene who would potentially benefit from helicopter emergency medical services (HEMS).Summary background dataAlthough survival benefits have been shown at the population level, identification of patients most likely to benefit from HEMS transport is imperative to justify the risks and cost of this intervention.MethodsRetrospective cohort study of subjects undergoing scene HEMS or ground emergency medical services (GEMS) in the National Trauma Databank (2007-2012). Data were split into training and validation sets. Subjects were grouped by triage criteria in the training set and regression used to determine which criteria had a survival benefit associated with HEMS. Points were assigned to these criteria to develop the Air Medical Prehospital Triage (AMPT) score. The score was applied in the validation set to determine whether subjects triaged to HEMS had a survival benefit when actually transported by helicopter.ResultsThere were 2,086,137 subjects included. Criteria identified for inclusion in the AMPT score included GCS 29, flail chest, hemo/pneumothorax, paralysis, and multisystem trauma. The optimal cutoff for triage to HEMS was ≥2 points. In subjects triaged to HEMS, actual transport by HEMS was associated with an increased odds of survival (AOR 1.28; 95% confidence interval [CI] 1.21-1.36, P
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- 2016
11. Not all prehospital time is equal
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Brown, Joshua B, Rosengart, Matthew R, Forsythe, Raquel M, Reynolds, Benjamin R, Gestring, Mark L, Hallinan, William M, Peitzman, Andrew B, Billiar, Timothy R, and Sperry, Jason L
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Public Health ,Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Physical Injury - Accidents and Adverse Effects ,Clinical Research ,Good Health and Well Being ,Adolescent ,Adult ,Aged ,Ambulances ,Emergency Medical Services ,Female ,Humans ,Injury Severity Score ,Male ,Middle Aged ,Pennsylvania ,Registries ,Time Factors ,Transportation of Patients ,Trauma Centers ,Triage ,Wounds and Injuries ,Outcome ,prehospital time ,emergency medical services ,intubation ,extrication ,Clinical sciences ,Nursing - Abstract
BackgroundTrauma is time sensitive, and minimizing prehospital (PH) time is appealing. However, most studies have not linked increasing PH time with worse outcomes because raw PH times are highly variable. It is unclear whether specific PH time patterns affect outcomes. Our objective was to evaluate the association of PH time interval distribution with mortality.MethodsPatients transported by emergency medical services in the Pennsylvania trauma registry from 2000 to 2013 with a total PH time (TPT) of 20 minutes or longer were included. TPT was divided into three PH time intervals: response, scene, and transport time. The number of minutes in each PH time interval was divided by TPT to determine the relative proportion each interval contributed to TPT. A prolonged interval was defined as any one PH interval contributing equal to or greater than 50% of TPT. Patients were classified by prolonged PH interval or no prolonged PH interval (all intervals < 50% of TPT). Patients were matched for TPT, and conditional logistic regression determined the association of mortality with PH time pattern, controlling for confounders. PH interventions were explored as potential mediators, and PH triage criteria used identify patients with time-sensitive injuries.ResultsThere were 164,471 patients included. Patients with prolonged scene time had increased odds of mortality (odds ratio, 1.21; 95% confidence interval, 1.02-1.44; p = 0.03). Prolonged response, transport, and no prolonged interval were not associated with mortality. When adjusting for mediators including extrication and PH intubation, prolonged scene time was no longer associated with mortality (odds ratio, 1.06; 95% confidence interval, 0.90-1.25; p = 0.50). Together, these factors mediated 61% of the effect between prolonged scene time and mortality. Mortality remained associated with prolonged scene time in patients with hypotension, penetrating injury, and flail chest.ConclusionProlonged scene time is associated with increased mortality. PH interventions partially mediate this association. Further study should evaluate whether these interventions drive increased mortality because they prolong scene time or by another mechanism, as reducing scene time may be a target for intervention.Level of evidencePrognostic/epidemiologic study, level III.
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- 2016
12. Helicopters and injured kids
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Brown, Joshua B, Leeper, Christine M, Sperry, Jason L, Peitzman, Andrew B, Billiar, Timothy R, Gaines, Barbara A, and Gestring, Mark L
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Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Clinical Research ,Pediatric ,Physical Injury - Accidents and Adverse Effects ,Good Health and Well Being ,Adolescent ,Air Ambulances ,Child ,Child ,Preschool ,Emergency Medical Services ,Female ,Follow-Up Studies ,Humans ,Injury Severity Score ,Male ,Multiple Trauma ,Odds Ratio ,Propensity Score ,Retrospective Studies ,Survival Rate ,Time Factors ,Time-to-Treatment ,Transportation of Patients ,Triage ,United States ,Young Adult ,Helicopter ,children ,outcomes ,prehospital ,emergency medical services ,Clinical sciences ,Nursing - Abstract
BackgroundHelicopter emergency medical services (HEMS) are frequently used to transport injured children, despite unclear evidence of benefit. The study objective was to evaluate the association of HEMS compared with ground emergency medical services (GEMS) transport with outcomes in a national sample of pediatric trauma patients.MethodsPatients 15 years or younger undergoing scene transport by HEMS or GEMS in the National Trauma Data Bank from 2007 to 2012 were included. Propensity score matching was used to match HEMS and GEMS patients for likelihood of HEMS transport based on demographics, prehospital physiology and time, injury severity, and geographic region. Absolute standardized differences of less than 0.1 indicated adequate covariate balance between groups after matching. The primary outcome was in-hospital survival, while the secondary outcome was discharge disposition in survivors. Conditional logistic regression determined the association between HEMS versus GEMS transport with outcomes while controlling for demographics, admission physiology, injury severity, nonaccidental trauma, and in-hospital complications not accounted for in the propensity score. Subgroup analysis was performed in patients with a transport time of greater than 15 minutes to capture patients with the potential for HEMS transport.ResultsA total of 25,700 HEMS/GEMS pairs were matched from 166,594 patients. Groups were well matched, with all propensity score variables having absolute standardized differences of less than 0.1. In matched patients, HEMS was associated with a 72% increase in odds of survival compared with GEMS (adjusted odds ratio, 1.72; 95% confidence interval, 1.26-2.36; p < 0.01). Transport mode was not associated with discharge disposition (p = 0.47). Subgroup analysis included 17,657 HEMS/GEMS pairs. HEMS was again associated with a significant increase in odds of survival (adjusted odds ratio, 1.81; 95% confidence interval, 1.24-2.65; p < 0.01), while transport mode was not associated with discharge disposition (p = 0.58).ConclusionScene transport by HEMS was associated with improved odds of survival compared with GEMS in pediatric trauma patients. Further study is warranted to understand the underlying mechanisms and develop specific triage criteria for HEMS transport in this population.Level of evidenceTherapeutic study, level III.
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- 2016
13. Helicopter transport improves survival following injury in the absence of a time-saving advantage
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Brown, Joshua B, Gestring, Mark L, Guyette, Francis X, Rosengart, Matthew R, Stassen, Nicole A, Forsythe, Raquel M, Billiar, Timothy R, Peitzman, Andrew B, and Sperry, Jason L
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Air Ambulances ,Ambulances ,Cohort Studies ,Emergency Medical Services ,Female ,Humans ,Injury Severity Score ,Logistic Models ,Male ,Multiple Trauma ,Odds Ratio ,Propensity Score ,Quality Improvement ,Retrospective Studies ,Risk Assessment ,Survival Analysis ,Time Factors ,Time-to-Treatment ,Transportation of Patients ,Surgery ,Clinical sciences - Abstract
BackgroundAlthough survival benefits have been shown at the population level, it remains unclear what drives the outcome benefits for helicopter emergency medical services (HEMS) in trauma. Although speed is often cited as the vital factor of HEMS, we hypothesized a survival benefit would exist in the absence of a time savings over ground emergency medical services (GEMS). The objective was to examine the association of survival with HEMS compared with GEMS transport across similar prehospital transport times.MethodsWe used a retrospective cohort of scene HEMS and GEMS transports in the National Trauma Databank (2007-2012). Propensity score matching was used to match HEMS and GEMS subjects on the likelihood of HEMS transport. Subjects were stratified by prehospital transport times in 5-minute increments. Conditional logistic regression determined the association of HEMS with survival across prehospital transport times strata controlling for confounders. Transport distance was estimated from prehospital transport times and average HEMS/GEMS transport speeds.ResultsThere were 155,691 HEMS/GEMS pairs matched. HEMS had a survival benefit over GEMS for prehospital transport times between 6 and 30 minutes. This benefit ranged from a 46% increase in odds of survival between 26 and 30 minutes (adjusted odds ratio [AOR], 1.46; 95% CI, 1.11-1.93; P < .01) to an 80% increase in odds of survival between 16 and 20 minutes (AOR, 1.80; 95% CI, 1.51-2.14; P < .01). This prehospital transport times window corresponds to estimated transport distance between 14.3 and 71.3 miles for HEMS and 3.3 and 16.6 miles for GEMS.ConclusionWhen stratified by prehospital transport times, HEMS had a survival benefit concentrated in a window between 6 and 30 minutes. Because there was no time-savings advantage for HEMS, these findings may reflect care delivered by HEMS providers.
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- 2016
14. Geographic Variation in Outcome Benefits of Helicopter Transport for Trauma in the United States
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Brown, Joshua B, Gestring, Mark L, Stassen, Nicole A, Forsythe, Raquel M, Billiar, Timothy R, Peitzman, Andrew B, and Sperry, Jason L
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Biomedical and Clinical Sciences ,Clinical Sciences ,Physical Injury - Accidents and Adverse Effects ,Clinical Research ,Good Health and Well Being ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Air Ambulances ,Databases ,Factual ,Female ,Healthcare Disparities ,Humans ,Logistic Models ,Male ,Middle Aged ,Outcome Assessment ,Health Care ,Propensity Score ,Retrospective Studies ,United States ,Wounds and Injuries ,Young Adult ,geographic ,helicopter ,outcome ,trauma ,variation ,Medical and Health Sciences ,Surgery ,Clinical sciences - Abstract
ObjectiveEvaluate the effect of US geographic region on outcomes of helicopter transport (HT) for trauma.BackgroundHT is an integral component of trauma systems. Evidence suggests that HT is associated with improved outcomes; however, no studies examine the impact of geographic variation on outcomes for HT.MethodsRetrospective cohort study of patients undergoing scene HT or ground transport in the National Trauma Databank (2009-2012). Subjects were divided by US census region. HT and ground transport subjects were propensity-score matched based on prehospital physiology and injury severity. Conditional logistic regression was used to evaluate the effect of HT on survival and discharge to home in each region. Region-level characteristics were assessed as potential explanatory factors.ResultsA total of 193,629 pairs were matched. HT was associated with increased odds of survival and discharge to home; however, the magnitude of these effects varied significantly across regions (P
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- 2016
15. Geographic distribution of trauma centers and injury-related mortality in the United States
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Brown, Joshua B, Rosengart, Matthew R, Billiar, Timothy R, Peitzman, Andrew B, and Sperry, Jason L
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Public Health ,Health Sciences ,Physical Injury - Accidents and Adverse Effects ,Clinical Research ,Good Health and Well Being ,Geography ,Hospital Mortality ,Humans ,Trauma Centers ,United States ,Wounds and Injuries ,Geospatial ,spatial ,trauma systems ,fatality rate ,nearest neighbor ,Clinical sciences ,Nursing - Abstract
BackgroundRegionalized trauma care improves outcomes; however, access to care is not uniform across the United States. The objective was to evaluate whether geographic distribution of trauma centers correlates with injury mortality across state trauma systems.MethodsLevel I or II trauma centers in the contiguous United States were mapped. State-level age-adjusted injury fatality rates per 100,000 people were obtained and evaluated for spatial autocorrelation. Nearest neighbor ratios (NNRs) were generated for each state. A NNR less than 1 indicates clustering, while a NNR greater than 1 indicates dispersion. NNRs were tested for difference from random geographic distribution. Fatality rates and NNRs were examined for correlation. Fatality rates were compared between states with trauma center clustering versus dispersion. Trauma center distribution and population density were evaluated. Spatial-lag regression determined the association between fatality rate and NNR, controlling for state-level demographics, population density, injury severity, trauma system resources, and socioeconomic factors.ResultsFatality rates were spatially autocorrelated (Moran's I = 0.35, p < 0.01). Nine states had a clustered pattern (median NNR, 0.55; interquartile range [IQR], 0.48-0.60), 22 had a dispersed pattern (median NNR, 2.00; IQR, 1.68-3.99), and 10 had a random pattern (median NNR, 0.90; IQR, 0.85-1.00) of trauma center distribution. Fatality rate and NNR were correlated (ρ = 0.34, p = 0.03). Clustered states had a lower median injury fatality rate compared with dispersed states (56.9 [IQR, 46.5-58.9] vs. 64.9 [IQR, 52.5-77.1]; p = 0.04). Dispersed compared with clustered states had more counties without a trauma center that had higher population density than counties with a trauma center (5.7% vs. 1.2%, p < 0.01). Spatial-lag regression demonstrated that fatality rates increased by 0.02 per 100,000 persons for each unit increase in NNR (p < 0.01).ConclusionGeographic distribution of trauma centers correlates with injury mortality, with more clustered state trauma centers associated with lower fatality rates. This may be a result of access relative to population density. These results may have implications for trauma system planning and require further study to investigate underlying mechanisms.Level of evidenceTherapeutic/care management study, level IV.
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- 2016
16. 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy
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de’Angelis, Nicola, Catena, Fausto, Memeo, Riccardo, Coccolini, Federico, Martínez-Pérez, Aleix, Romeo, Oreste M., De Simone, Belinda, Di Saverio, Salomone, Brustia, Raffaele, Rhaiem, Rami, Piardi, Tullio, Conticchio, Maria, Marchegiani, Francesco, Beghdadi, Nassiba, Abu-Zidan, Fikri M., Alikhanov, Ruslan, Allard, Marc-Antoine, Allievi, Niccolò, Amaddeo, Giuliana, Ansaloni, Luca, Andersson, Roland, Andolfi, Enrico, Azfar, Mohammad, Bala, Miklosh, Benkabbou, Amine, Ben-Ishay, Offir, Bianchi, Giorgio, Biffl, Walter L., Brunetti, Francesco, Carra, Maria Clotilde, Casanova, Daniel, Celentano, Valerio, Ceresoli, Marco, Chiara, Osvaldo, Cimbanassi, Stefania, Bini, Roberto, Coimbra, Raul, Luigi de’Angelis, Gian, Decembrino, Francesco, De Palma, Andrea, de Reuver, Philip R., Domingo, Carlos, Cotsoglou, Christian, Ferrero, Alessandro, Fraga, Gustavo P., Gaiani, Federica, Gheza, Federico, Gurrado, Angela, Harrison, Ewen, Henriquez, Angel, Hofmeyr, Stefan, Iadarola, Roberta, Kashuk, Jeffry L., Kianmanesh, Reza, Kirkpatrick, Andrew W., Kluger, Yoram, Landi, Filippo, Langella, Serena, Lapointe, Real, Le Roy, Bertrand, Luciani, Alain, Machado, Fernando, Maggi, Umberto, Maier, Ronald V., Mefire, Alain Chichom, Hiramatsu, Kazuhiro, Ordoñez, Carlos, Patrizi, Franca, Planells, Manuel, Peitzman, Andrew B., Pekolj, Juan, Perdigao, Fabiano, Pereira, Bruno M., Pessaux, Patrick, Pisano, Michele, Puyana, Juan Carlos, Rizoli, Sandro, Portigliotti, Luca, Romito, Raffaele, Sakakushev, Boris, Sanei, Behnam, Scatton, Olivier, Serradilla-Martin, Mario, Schneck, Anne-Sophie, Sissoko, Mohammed Lamine, Sobhani, Iradj, ten Broek, Richard P., Testini, Mario, Valinas, Roberto, Veloudis, Giorgos, Vitali, Giulio Cesare, Weber, Dieter, Zorcolo, Luigi, Giuliante, Felice, Gavriilidis, Paschalis, Fuks, David, and Sommacale, Daniele
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- 2021
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17. WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections
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Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Agastra, Ervis, Abu-Zidan, Fikri M., Abbas, Ashraf El Sayed, Ansaloni, Luca, Adesunkanmi, Abdulrashid Kayode, Atanasov, Boyko, Augustin, Goran, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Biffl, Walter L., Boermeester, Marja A., Ceresoli, Marco, Cerutti, Elisabetta, Chiara, Osvaldo, Cicuttin, Enrico, Chiarugi, Massimo, Coimbra, Raul, Colak, Elif, Corsi, Daniela, Cortese, Francesco, Cui, Yunfeng, Damaskos, Dimitris, de’ Angelis, Nicola, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, de Jonge, Stijn W., Dhingra, Sameer, Di Bella, Stefano, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Duane, Therese M., Enani, Mushira Abdulaziz, Fugazzola, Paola, Galante, Joseph M., Gachabayov, Mahir, Ghnnam, Wagih, Gkiokas, George, Gomes, Carlos Augusto, Griffiths, Ewen A., Hardcastle, Timothy C., Hecker, Andreas, Herzog, Torsten, Kabir, Syed Mohammad Umar, Karamarkovic, Aleksandar, Khokha, Vladimir, Kim, Peter K., Kim, Jae Il, Kirkpatrick, Andrew W., Kong, Victor, Koshy, Renol M., Kryvoruchko, Igor A., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao, Labricciosa, Francesco M., Lee, Yeong Yeh, Leppäniemi, Ari, Litvin, Andrey, Luppi, Davide, Machain, Gustavo M., Maier, Ronald V., Marinis, Athanasios, Marmorale, Cristina, Marwah, Sanjay, Mesina, Cristian, Moore, Ernest E., Moore, Frederick A., Negoi, Ionut, Olaoye, Iyiade, Ordoñez, Carlos A., Ouadii, Mouaqit, Peitzman, Andrew B., Perrone, Gennaro, Pikoulis, Manos, Pintar, Tadeja, Pipitone, Giuseppe, Podda, Mauro, Raşa, Kemal, Ribeiro, Julival, Rodrigues, Gabriel, Rubio-Perez, Ines, Sall, Ibrahima, Sato, Norio, Sawyer, Robert G., Segovia Lohse, Helmut, Sganga, Gabriele, Shelat, Vishal G., Stephens, Ian, Sugrue, Michael, Tarasconi, Antonio, Tochie, Joel Noutakdie, Tolonen, Matti, Tomadze, Gia, Ulrych, Jan, Vereczkei, Andras, Viaggi, Bruno, Gurioli, Chiara, Casella, Claudio, Pagani, Leonardo, Baiocchi, Gian Luca, and Catena, Fausto
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- 2021
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18. Diagnosis and management of small bowel obstruction in virgin abdomen: a WSES position paper
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Amara, Yousef, Leppaniemi, Ari, Catena, Fausto, Ansaloni, Luca, Sugrue, Michael, Fraga, Gustavo P., Coccolini, Federico, Biffl, Walter L., Peitzman, Andrew B., Kluger, Yoram, Sartelli, Massimo, Moore, Ernest E., Di Saverio, Salomone, Darwish, Esfo, Endo, Chikako, van Goor, Harry, and ten Broek, Richard P.
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- 2021
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19. Pretrauma Center Red Blood Cell Transfusion Is Associated With Reduced Mortality and Coagulopathy in Severely Injured Patients With Blunt Trauma
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Brown, Joshua B, Cohen, Mitchell J, Minei, Joseph P, Maier, Ronald V, West, Michaela A, Billiar, Timothy R, Peitzman, Andrew B, Moore, Ernest E, Cuschieri, Joseph, and Sperry, Jason L
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Biomedical and Clinical Sciences ,Clinical Sciences ,Physical Injury - Accidents and Adverse Effects ,Clinical Research ,Good Health and Well Being ,Adult ,Blood Coagulation Disorders ,Emergency Medical Services ,Endopeptidase Clp ,Erythrocyte Transfusion ,Female ,Heat-Shock Proteins ,Humans ,Injury Severity Score ,Male ,Middle Aged ,Propensity Score ,Prospective Studies ,Protozoan Proteins ,Shock ,Hemorrhagic ,Treatment Outcome ,Wounds ,Nonpenetrating ,blood ,prehospital ,resuscitation ,trauma ,transfusion ,Inflammation and the Host Response to Injury Investigators ,Medical and Health Sciences ,Surgery ,Clinical sciences - Abstract
ObjectiveTo evaluate the association of pretrauma center (PTC) red blood cell (RBC) transfusion with outcomes in severely injured patients.BackgroundHemorrhage remains a major driver of mortality. Little evidence exists supporting PTC interventions to mitigate this.MethodsBlunt injured patients in shock arriving at a trauma center within 2 hours of injury were included from the Glue Grant database. Subjects were dichotomized by PTC RBC transfusion. Outcomes included 24-hour mortality, 30-day mortality, and trauma-induced coagulopathy [(TIC), admission international normalized ratio >1.5]. Cox regression and logistic regression determined the association of PTC RBC transfusion with outcomes. To address baseline differences, propensity score matching was used.ResultsOf 1415 subjects, 50 received PTC RBC transfusion. Demographics and injury severity score were similar. The PTC RBC group received 1.3 units of RBCs (median), and 52% were scene transports. PTC RBC transfusion was associated with a 95% reduction in odds of 24-hour mortality [odds ratio (OR) = 0.05; 95% confidence interval (CI), 0.01-0.48; P < 0.01], 64% reduction in the risk of 30-day mortality [hazard ratio = 0.36; 95% CI, 0.15-0.83; P = 0.02], and 88% reduction in odds of TIC (OR = 0.12; 95% CI, 0.02-0.79; P = 0.03). The matched cohort included 113 subjects (31% PTC RBC group). Baseline characteristics were similar. PTC RBC transfusion was associated with a 98% reduction in odds of 24-hour mortality (OR = 0.02; 95% CI, 0.01-0.69; P = 0.04), 88% reduction in the risk of 30-day mortality (hazard ratio = 0.12; 95% CI, 0.03-0.61; P = 0.01), and 99% reduction in odds of TIC (OR = 0.01; 95% CI, 0.01-0.95; P = 0.05).ConclusionsPTC RBC administration was associated with a lower risk of 24-hour mortality, 30-day mortality, and TIC in severely injured patients with blunt trauma, warranting further prospective study.
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- 2015
20. Prehospital Use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Is Associated With a Reduced Incidence of Trauma-Induced Coagulopathy
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Neal, Matthew D, Brown, Joshua B, Moore, Ernest E, Cuschieri, Joseph, Maier, Ronald V, Minei, Joseph P, Billiar, Timothy R, Peitzman, Andrew B, Cohen, Mitchell J, and Sperry, Jason L
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Physical Injury - Accidents and Adverse Effects ,Aetiology ,2.1 Biological and endogenous factors ,Adult ,Anti-Inflammatory Agents ,Non-Steroidal ,Blood Coagulation Disorders ,Blood Transfusion ,Comorbidity ,Female ,Humans ,Incidence ,International Normalized Ratio ,Male ,Middle Aged ,Risk Assessment ,Risk Factors ,Trauma Severity Indices ,Wounds and Injuries ,acute coagulopathy of trauma ,Glue Grant ,inflammation ,NSAID ,trauma ,Inflammation and Host Response to Injury Investigators ,Medical and Health Sciences ,Surgery ,Clinical sciences - Abstract
ObjectiveTo determine whether prehospital nonsteroidal anti-inflammatory drug (NSAID) use may lead to a reduced incidence of trauma-induced coagulopathy (TIC) in severely injured patients.BackgroundTIC is present in up to a quarter of severely injured trauma patients and is linked to worse outcomes after injury. Evidence linking TIC to inflammation has emerged; however, the mechanism behind this association is still under investigation. NSAIDs are commonly used anti-inflammatory drugs, but their effects on TIC and outcomes after injury are largely unexplored.MethodsWe performed a secondary analysis of the Inflammation and the Host Response to Injury Large Scale Collaborative Program (Glue Grant) data set. Prehospital medications and comorbidities were analyzed by logistic regression analysis for association with TIC as defined by laboratory (international normalized ratio >1.5) or clinical (transfusion >2 units of fresh frozen plasma or >1 pack of platelets in 6 hours) parameters.ResultsPrehospital NSIAD use was independently associated with a 72% lower risk of TIC and was the only medication among 15 analyzed to retain significance in the model. Stepwise logistic regression also demonstrated that preadmission use of NSAIDs was independently associated with a 66% lower risk of clinically significant coagulopathy. These findings were independent of comorbid conditions linked to NSAID use.ConclusionsNSAID use before admission for severe injury is associated with a reduced incidence of TIC. These findings provide further evidence to a potential leak between TIC and inflammation.
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- 2014
21. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines
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Di Saverio, Salomone, Podda, Mauro, De Simone, Belinda, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, de’ Angelis, Nicola, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Ten Broek, Richard, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppäniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, de’ Angelis, Gian Luigi, Tan, Edward, Van Goor, Harry, Pata, Francesco, Di Carlo, Isidoro, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Abu-Zidan, Fakri, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, and Catena, Fausto
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- 2020
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22. 2023 WSES guidelines for the prevention, detection, and management of iatrogenic urinary tract injuries (IUTIs) during emergency digestive surgery
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De'Angelis, Nicola, Schena, Carlo Alberto, Marchegiani, Francesco, Reitano, Elisa, De Simone, Belinda, Wong, Geoffrey Yuet Mun, Martínez-Pérez, Aleix, Abu-Zidan, Fikri M, Agnoletti, Vanni, Aisoni, Filippo, Ammendola, Michele, Ansaloni, Luca, Bala, Miklosh, Biffl, Walter, Ceccarelli, Graziano, Ceresoli, Marco, Chiara, Osvaldo, Chiarugi, Massimo, Cimbanassi, Stefania, Coccolini, Federico, Coimbra, Raul, Di Saverio, Salomone, Diana, Michele, Dioguardi Burgio, Marco, Fraga, Gustavo, Gavriilidis, Paschali, Gurrado, Angela, Inchingolo, Riccardo, Ingels, Alexandre, Ivatury, Rao, Kashuk, Jeffry L, Khan, Jim, Kirkpatrick, Andrew W, Kim, Fernando J, Kluger, Yoram, Lakkis, Zaher, Leppäniemi, Ari, Maier, Ronald V, Memeo, Riccardo, Moore, Ernest E, Ordoñez, Carlos A, Peitzman, Andrew B, Pellino, Gianluca, Picetti, Edoardo, Pikoulis, Mano, Pisano, Michele, Podda, Mauro, Romeo, Oreste, Rosa, Fausto, Tan, Edward, Ten Broek, Richard P, Testini, Mario, Tian Wei Cheng, Brian Anthony, Weber, Dieter, Sacco, Emilio, Sartelli, Massimo, Tonsi, Alfredo, Dal Moro, Fabrizio, Catena, Fausto, Rosa, Fausto (ORCID:0000-0002-7280-8354), Sacco, Emilio (ORCID:0000-0003-4640-8354), De'Angelis, Nicola, Schena, Carlo Alberto, Marchegiani, Francesco, Reitano, Elisa, De Simone, Belinda, Wong, Geoffrey Yuet Mun, Martínez-Pérez, Aleix, Abu-Zidan, Fikri M, Agnoletti, Vanni, Aisoni, Filippo, Ammendola, Michele, Ansaloni, Luca, Bala, Miklosh, Biffl, Walter, Ceccarelli, Graziano, Ceresoli, Marco, Chiara, Osvaldo, Chiarugi, Massimo, Cimbanassi, Stefania, Coccolini, Federico, Coimbra, Raul, Di Saverio, Salomone, Diana, Michele, Dioguardi Burgio, Marco, Fraga, Gustavo, Gavriilidis, Paschali, Gurrado, Angela, Inchingolo, Riccardo, Ingels, Alexandre, Ivatury, Rao, Kashuk, Jeffry L, Khan, Jim, Kirkpatrick, Andrew W, Kim, Fernando J, Kluger, Yoram, Lakkis, Zaher, Leppäniemi, Ari, Maier, Ronald V, Memeo, Riccardo, Moore, Ernest E, Ordoñez, Carlos A, Peitzman, Andrew B, Pellino, Gianluca, Picetti, Edoardo, Pikoulis, Mano, Pisano, Michele, Podda, Mauro, Romeo, Oreste, Rosa, Fausto, Tan, Edward, Ten Broek, Richard P, Testini, Mario, Tian Wei Cheng, Brian Anthony, Weber, Dieter, Sacco, Emilio, Sartelli, Massimo, Tonsi, Alfredo, Dal Moro, Fabrizio, Catena, Fausto, Rosa, Fausto (ORCID:0000-0002-7280-8354), and Sacco, Emilio (ORCID:0000-0003-4640-8354)
- Abstract
Iatrogenic urinary tract injury (IUTI) is a severe complication of emergency digestive surgery. It can lead to increased postoperative morbidity and mortality and have a long-term impact on the quality of life. The reported incidence of IUTIs varies greatly among the studies, ranging from 0.3 to 1.5%. Given the high volume of emergency digestive surgery performed worldwide, there is a need for well-defined and effective strategies to prevent and manage IUTIs. Currently, there is a lack of consensus regarding the prevention, detection, and management of IUTIs in the emergency setting. The present guidelines, promoted by the World Society of Emergency Surgery (WSES), were developed following a systematic review of the literature and an international expert panel discussion. The primary aim of these WSES guidelines is to provide evidence-based recommendations to support clinicians and surgeons in the prevention, detection, and management of IUTIs during emergency digestive surgery. The following key aspects were considered: (1) effectiveness of preventive interventions for IUTIs during emergency digestive surgery; (2) intra-operative detection of IUTIs and appropriate management strategies; (3) postoperative detection of IUTIs and appropriate management strategies and timing; and (4) effectiveness of antibiotic therapy (including type and duration) in case of IUTIs.
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- 2023
23. Prehospital low titer group O whole blood is feasible and safe: Results of a prospective randomized pilot trial
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Guyette, Frank X., Zenati, Mazen, Triulzi, Darrell J., Yazer, Mark H., Skroczky, Hunter, Early, Barbara J., Adams, Peter W., Brown, Joshua B., Alarcon, Louis, Neal, Matthew D., Forsythe, Raquel M., Zuckerbraun, Brian S., Peitzman, Andrew B., Billiar, Timothy R., and Sperry, Jason L.
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Surgery ,Critical Care and Intensive Care Medicine ,Article - Abstract
INTRODUCTION: Low titer group O whole blood (LTOWB) resuscitation is increasingly common in both military and civilian settings. Data regarding the safety and efficacy of prehospital LTOWB remains limited. METHODS: We performed a single center, prospective, cluster randomized, prehospital thru in-hospital whole blood pilot trial for injured air medical patients. We compared standard prehospital air medical care including red cell transfusion and crystalloids followed by in-hospital component transfusion to prehospital and in-hospital LTOWB resuscitation. Prehospital vital signs were used as inclusion criteria (SBP ≤ 90 mmHg and HR ≥ 108 bpm) or (SBP ≤ 70 mmHg) for patients at risk of hemorrhage. Primary outcome was feasibility. Secondary outcomes included 28-day and 24 hour mortality, multiple organ failure, nosocomial infection, 24hr transfusion requirements and arrival coagulation parameters. RESULTS: Between November 2018 thru October 2020, 86 injured patients were cluster randomized by helicopter base. The trial has halted early at 77% enrollment. Overall, 28-day mortality for the cohort was 26%. Injured patients randomized to prehospital LTOWB (n=40) relative to standard care (n=46) were similar in demographics and injury characteristics. Intent to treat Kaplan-Meier survival analysis demonstrated no statistical mortality benefit at 28 days (25.0% vs. 26.1%, p= 0.85). Patients randomized to prehospital LTOWB relative to standard care had lower red cell transfusion requirements at 24 hours (p
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- 2022
24. Additional file 1 of Prediction of morbidity and mortality after early cholecystectomy for acute calculous cholecystitis: results of the S.P.Ri.M.A.C.C. study
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Fugazzola, Paola, Cobianchi, Lorenzo, Di Martino, Marcello, Tomasoni, Matteo, Dal Mas, Francesca, Abu-Zidan, Fikri M., Agnoletti, Vanni, Ceresoli, Marco, Coccolini, Federico, Di Saverio, Salomone, Dominioni, Tommaso, Farè, Camilla Nikita, Frassini, Simone, Gambini, Giulia, Leppäniemi, Ari, Maestri, Marcello, Martín-Pérez, Elena, Moore, Ernest E., Musella, Valeria, Peitzman, Andrew B., de la Hoz Rodríguez, Ángela, Sargenti, Benedetta, Sartelli, Massimo, Viganò, Jacopo, Anderloni, Andrea, Biffl, Walter, Catena, Fausto, and Ansaloni, Luca
- Abstract
Additional file 1. Centers included in S.P.Ri.M.A.C.C. study with number of patients.
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- 2023
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25. Lipidomic signatures align with inflammatory patterns and outcomes in critical illness
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Wu, Junru, Cyr, Anthony, Gruen, Danielle S., Lovelace, Tyler C., Benos, Panayiotis V., Das, Jishnu, Kar, Upendra K., Chen, Tianmeng, Guyette, Francis X., Yazer, Mark H., Daley, Brian J., Miller, Richard S., Harbrecht, Brian G., Claridge, Jeffrey A., Phelan, Herb A., Zuckerbraun, Brian S., Neal, Matthew D., Johansson, Pär I., Stensballe, Jakob, Namas, Rami A., Vodovotz, Yoram, Sperry, Jason L., Billiar, Timothy R., Zenati, Mazen S., Brown, Joshua B., Triulzi, Darrell J., Young, Barbara J.Early, Adams, Peter W., Alarcon, Louis H., Callaway, Clifton W., Forsythe, Raquel M., Yealy, Donald M., Peitzman, Andrew B., Buck, Meghan L., Ryman, Ashley M., Gimbel, Elizabeth A., Gilchrist, Erin G., Buhay, Meghan, Chang, Chung Chou H., Talisa, Victor B., Xu, Tianyuan, Kalloway, Kyle, Yates, Andrew, Rawn, Susan, Jenkins, Judith M., Trachtenberg, Laura S., Eden, Randi K., Fraifogl, Joanne, Bates, Craig, and Howard, Christina
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Inflammation ,Inflammation biomarkers ,Multidisciplinary ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Critical Illness ,Clinical course ,COVID-19 ,General Physics and Astronomy ,Lipid metabolism ,General Chemistry ,Lipidome ,Bioinformatics ,Article ,General Biochemistry, Genetics and Molecular Biology ,Critical illness ,Lipogenesis ,Lipidomics ,Medicine ,Humans ,Fresh frozen plasma ,business ,Biomarkers - Abstract
Alterations in lipid metabolism have the potential to be markers as well as drivers of the pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. Early in the clinical course, Fresh Frozen Plasma administration led to improved survival in association with preserved lipid levels that related to favorable changes in coagulation and inflammation biomarkers. Late over-representation of phosphatidylethanolamines with critical illness led to the validation of a Lipid Reprogramming Score that was prognostic not only in trauma but also severe COVID-19 patients. Our lipidomic findings provide a new paradigm for the lipid response underlying critical illness.
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- 2022
26. Blunt cerebrovascular injury in elderly fall patients: are we screening enough?
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Anto, Vincent P., Brown, Joshua B., Peitzman, Andrew B., Zuckerbraun, Brian S., Neal, Matthew D., Watson, Gregory, Forsythe, Raquel, Billiar, Timothy R., and Sperry, Jason L.
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- 2018
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27. Acute mesenteric ischemia:updated guidelines of the World Society of Emergency Surgery
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Bala, Miklosh, Catena, Fausto, Kashuk, Jeffry, De Simone, Belinda, Gomes, Carlos Augusto, Weber, Dieter, Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Abu-Zidan, Fikri M., Picetti, Edoardo, Ansaloni, Luca, Augustin, Goran, Biffl, Walter L., Ceresoli, Marco, Chiara, Osvaldo, Chiarugi, Massimo, Coimbra, Raul, Cui, Yunfeng, Damaskos, Dimitris, Di Saverio, Salomone, Galante, Joseph M., Khokha, Vladimir, Kirkpatrick, Andrew W., Inaba, Kenji, Leppäniemi, Ari, Litvin, Andrey, Peitzman, Andrew B., Shelat, Vishal G., Sugrue, Michael, Tolonen, Matti, Rizoli, Sandro, Sall, Ibrahima, Beka, Solomon G., Di Carlo, Isidoro, Ten Broek, Richard, Mircea, Chirika, Tebala, Giovanni, Pisano, Michele, van Goor, Harry, Maier, Ronald V., Jeekel, Hans, Civil, Ian, Hecker, Andreas, Tan, Edward, Soreide, Kjetil, Lee, Matthew J., Wani, Imtiaz, Bonavina, Luigi, Malangoni, Mark A., Koike, Kaoru, Velmahos, George C., Fraga, Gustavo P., Fette, Andreas, de’Angelis, Nicola, Balogh, Zsolt J., Scalea, Thomas M., Sganga, Gabriele, Kelly, Michael D., Khan, Jim, Stahel, Philip F., Moore, Ernest E., Bala, Miklosh, Catena, Fausto, Kashuk, Jeffry, De Simone, Belinda, Gomes, Carlos Augusto, Weber, Dieter, Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Abu-Zidan, Fikri M., Picetti, Edoardo, Ansaloni, Luca, Augustin, Goran, Biffl, Walter L., Ceresoli, Marco, Chiara, Osvaldo, Chiarugi, Massimo, Coimbra, Raul, Cui, Yunfeng, Damaskos, Dimitris, Di Saverio, Salomone, Galante, Joseph M., Khokha, Vladimir, Kirkpatrick, Andrew W., Inaba, Kenji, Leppäniemi, Ari, Litvin, Andrey, Peitzman, Andrew B., Shelat, Vishal G., Sugrue, Michael, Tolonen, Matti, Rizoli, Sandro, Sall, Ibrahima, Beka, Solomon G., Di Carlo, Isidoro, Ten Broek, Richard, Mircea, Chirika, Tebala, Giovanni, Pisano, Michele, van Goor, Harry, Maier, Ronald V., Jeekel, Hans, Civil, Ian, Hecker, Andreas, Tan, Edward, Soreide, Kjetil, Lee, Matthew J., Wani, Imtiaz, Bonavina, Luigi, Malangoni, Mark A., Koike, Kaoru, Velmahos, George C., Fraga, Gustavo P., Fette, Andreas, de’Angelis, Nicola, Balogh, Zsolt J., Scalea, Thomas M., Sganga, Gabriele, Kelly, Michael D., Khan, Jim, Stahel, Philip F., and Moore, Ernest E.
- Abstract
Acute mesenteric ischemia (AMI) is a group of diseases characterized by an interruption of the blood supply to varying portions of the intestine, leading to ischemia and secondary inflammatory changes. If untreated, this process may progress to life-threatening intestinal necrosis. The incidence is low, estimated at 0.09–0.2% of all acute surgical admissions, but increases with age. Although the entity is an uncommon cause of abdominal pain, diligence is required because if untreated, mortality remains in the range of 50%. Early diagnosis and timely surgical intervention are the cornerstones of modern treatment to reduce the high mortality associated with this entity. The advent of endovascular approaches in parallel with modern imaging techniques is evolving and provides new treatment options. Lastly, a focused multidisciplinary approach based on early diagnosis and individualized treatment is essential. Thus, we believe that updated guidelines from World Society of Emergency Surgery are warranted, in order to provide the most recent and practical recommendations for diagnosis and treatment of AMI.
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- 2022
28. Additional file 1 of Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery
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Bala, Miklosh, Catena, Fausto, Kashuk, Jeffry, De Simone, Belinda, Gomes, Carlos Augusto, Weber, Dieter, Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Abu-Zidan, Fikri M., Picetti, Edoardo, Ansaloni, Luca, Augustin, Goran, Biffl, Walter L., Ceresoli, Marco, Chiara, Osvaldo, Chiarugi, Massimo, Coimbra, Raul, Cui, Yunfeng, Damaskos, Dimitris, Di Saverio, Salomone, Galante, Joseph M., Khokha, Vladimir, Kirkpatrick, Andrew W., Inaba, Kenji, Leppäniemi, Ari, Litvin, Andrey, Peitzman, Andrew B., Shelat, Vishal G., Sugrue, Michael, Tolonen, Matti, Rizoli, Sandro, Sall, Ibrahima, Beka, Solomon G., Di Carlo, Isidoro, Ten Broek, Richard, Mircea, Chirika, Tebala, Giovanni, Pisano, Michele, van Goor, Harry, Maier, Ronald V., Jeekel, Hans, Civil, Ian, Hecker, Andreas, Tan, Edward, Soreide, Kjetil, Lee, Matthew J., Wani, Imtiaz, Bonavina, Luigi, Malangoni, Mark A., Koike, Kaoru, Velmahos, George C., Fraga, Gustavo P., Fette, Andreas, de’Angelis, Nicola, Balogh, Zsolt J., Scalea, Thomas M., Sganga, Gabriele, Kelly, Michael D., Khan, Jim, Stahel, Philip F., and Moore, Ernest E.
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Additional file 1: Table S3. Summary of the updated 2022 guidelines for AMI: statements and recommendations.
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- 2022
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29. WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections
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Sartelli, Massimo Coccolini, Federico Kluger, Yoram Agastra, Ervis Abu-Zidan, Fikri M. Abbas, Ashraf El Sayed Ansaloni, Luca Adesunkanmi, Abdulrashid Kayode Augustin, Goran Bala, Miklosh Baraket, Oussama Biffl, Walter L. Ceresoli, Marco and Cerutti, Elisabetta Chiara, Osvaldo Cicuttin, Enrico and Chiarugi, Massimo Coimbra, Raul Corsi, Daniela Cortese, Francesco Cui, Yunfeng Damaskos, Dimitris de'Angelis, Nicola and Delibegovic, Samir Demetrashvili, Zaza De Simone, Belinda and de Jonge, Stijn W. Di Bella, Stefano Di Saverio, Salomone and Duane, Therese M. Fugazzola, Paola Galante, Joseph M. and Ghnnam, Wagih Gkiokas, George Gomes, Carlos Augusto and Griffiths, Ewen A. Hardcastle, Timothy C. Hecker, Andreas and Herzog, Torsten Karamarkovic, Aleksandar Khokha, Vladimir and Kim, Peter K. Kim, Jae Il Kirkpatrick, Andrew W. Kong, Victor Koshy, Renol M. Inaba, Kenji Isik, Arda Ivatury, Rao Labricciosa, Francesco M. Lee, Yeong Yeh Leppaniemi, Ari and Litvin, Andrey Luppi, Davide Maier, Ronald V. Marinis, Athanasios Marwah, Sanjay Mesina, Cristian Moore, Ernest E. and Moore, Frederick A. Negoi, Ionut Olaoye, Iyiade Ordonez, Carlos A. Ouadii, Mouaqit Peitzman, Andrew B. Perrone, Gennaro Pintar, Tadeja Pipitone, Giuseppe Podda, Mauro and Rasa, Kemal Ribeiro, Julival Rodrigues, Gabriel Rubio-Perez, Ines Sall, Ibrahima Sato, Norio Sawyer, Robert G. and Shelat, Vishal G. Sugrue, Michael Tarasconi, Antonio and Tolonen, Matti Viaggi, Bruno Celotti, Andrea Casella, Claudio Pagani, Leonardo Dhingra, Sameer Baiocchi, Gian Luca and Catena, Fausto
- Abstract
Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections. Together, the World Society of Emergency Surgery, the Global Alliance for Infections in Surgery, the Surgical Infection Society-Europe, The World Surgical Infection Society, and the American Association for the Surgery of Trauma have jointly completed an international multi-society document to promote global standards of care in SSTIs guiding clinicians by describing reasonable approaches to the management of SSTIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting evidence was shared by an international task force with different clinical backgrounds.
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- 2022
30. The WSES/SICG/ACOI/SICUT/AcEMC/SIFIPAC guidelines for diagnosis and treatment of acute left colonic diverticulitis in the elderly
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Fugazzola, Paola Ceresoli, Marco Coccolini, Federico and Gabrielli, Francesco Puzziello, Alessandro Monzani, Fabio and Amato, Bruno Sganga, Gabriele Sartelli, Massimo Menichetti, Francesco Puglisi, Gabriele Adolfo Tartaglia, Dario and Carcoforo, Paolo Avenia, Nicola Kluger, Yoram Paolillo, Ciro and Zago, Mauro Leppaniemi, Ari Tomasoni, Matteo Cobianchi, Lorenzo Dal Mas, Francesca Improta, Mario Moore, Ernest E. and Peitzman, Andrew B. Sugrue, Michael Agnoletti, Vanni and Fraga, Gustavo P. Weber, Dieter G. Damaskos, Dimitrios and Abu-Zidan, Fikri M. Wani, Imtiaz Kirkpatrick, Andrew W. and Pikoulis, Manos Pararas, Nikolaos Tan, Edward Ten Broek, Richard Maier, V, Ronald Davies, R. Justin Kashuk, Jeffry and Shelat, Vishal G. Mefire, Alain Chicom Augustin, Goran and Magnone, Stefano Poiasina, Elia De Simone, Belinda Chiarugi, Massimo Biffl, Walt Baiocchi, Gian Luca Catena, Fausto and Ansaloni, Luca
- Abstract
Acute left colonic diverticulitis (ALCD) in the elderly presents with unique epidemiological features when compared with younger patients. The clinical presentation is more nuanced in the elderly population, having higher in-hospital and postoperative mortality. Furthermore, geriatric comorbidities are a risk factor for complicated diverticulitis. Finally, elderly patients have a lower risk of recurrent episodes and, in case of recurrence, a lower probability of requiring urgent surgery than younger patients. The aim of the present work is to study age-related factors that may support a unique approach to the diagnosis and treatment of this problem in the elderly when compared with the WSES guidelines for the management of acute left-sided colonic diverticulitis. During the 1 degrees Pisa Workshop of Acute Care & Trauma Surgery held in Pisa (Italy) in September 2019, with the collaboration of the World Society of Emergency Surgery (WSES), the Italian Society of Geriatric Surgery (SICG), the Italian Hospital Surgeons Association (ACOI), the Italian Emergency Surgery and Trauma Association (SICUT), the Academy of Emergency Medicine and Care (AcEMC) and the Italian Society of Surgical Pathophysiology (SIFIPAC), three panel members presented a number of statements developed for each of the four themes regarding the diagnosis and management of ALCD in older patients, formulated according to the GRADE approach, at a Consensus Conference where a panel of experts participated. The statements were subsequently debated, revised, and finally approved by the Consensus Conference attendees. The current paper is a summary report of the definitive guidelines statements on each of the following topics: diagnosis, management, surgical technique and antibiotic therapy.
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- 2022
31. Making the Call in the Field: Validating EMS Identification of Anatomic Trauma Triage Criteria
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Deeb, Andrew-Paul, Phelos, Heather M., Peitzman, Andrew B., Billiar, Timothy R., Sperry, Jason L., and Brown, Joshua B.
- Subjects
Adult ,Male ,Emergency Medical Services ,Trauma Severity Indices ,Clinical Coding ,Middle Aged ,Article ,Trauma Centers ,Predictive Value of Tests ,Practice Guidelines as Topic ,Humans ,Wounds and Injuries ,Female ,Triage ,Aged ,Retrospective Studies - Abstract
The National Field Triage Guidelines were created to inform triage decisions by emergency medical services (EMS) providers and include eight anatomic injuries that prompt transportation to a Level I/II trauma center. It is unclear how accurately EMS providers recognize these injuries. Our objective was to compare EMS-identified anatomic triage criteria with International Classification of Diseases-10th revision (ICD-10) coding of these criteria, as well as their association with trauma center need (TCN).Scene patients 16 years and older in the NTDB during 2017 were included. National Field Triage Guidelines anatomic criteria were classified based on EMS documentation and ICD-10 diagnosis codes. The primary outcome was TCN, a composite of Injury Severity Score greater than 15, intensive care unit admission, urgent surgery, or emergency department death. Prevalence of anatomic criteria and their association with TCN was compared in EMS-identified versus ICD-10-coded criteria. Diagnostic performance to predict TCN was compared.There were 669,795 patients analyzed. The ICD-10 coding demonstrated a greater prevalence of injury detection. Emergency medical service-identified versus ICD-10-coded anatomic criteria were less sensitive (31% vs. 59%), but more specific (91% vs. 73%) and accurate (71% vs. 68%) for predicting TCN. Emergency medical service providers demonstrated a marked reduction in false positives (9% vs. 27%) but higher rates of false negatives (69% vs. 42%) in predicting TCN from anatomic criteria. Odds of TCN were significantly greater for EMS-identified criteria (adjusted odds ratio, 4.5; 95% confidence interval, 4.46-4.58) versus ICD-10 coding (adjusted odds ratio 3.7; 95% confidence interval, 3.71-3.79). Of EMS-identified injuries, penetrating injury, flail chest, and two or more proximal long bone fractures were associated with greater TCN than ICD-10 coding.When evaluating the anatomic criteria, EMS demonstrate greater specificity and accuracy in predicting TCN, as well as reduced false positives compared with ICD-10 coding. Emergency medical services identification is less sensitive for anatomic criteria; however, EMS identify the most clinically significant injuries. Further study is warranted to identify the most clinically important anatomic triage criteria to improve our triage protocols.Care management, Level IV; Prognostic, Level III.
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- 2021
32. Necrotizing Soft Tissue Infections, the Challenge Remains
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Nawijn, Femke, primary, Hietbrink, Falco, additional, Peitzman, Andrew B., additional, and Leenen, Luke P. H., additional
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- 2021
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33. WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections
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Sartelli, Massimo Coccolini, Federico Kluger, Yoram Agastra, Ervis Abu-Zidan, Fikri M. Abbas, Ashraf El Sayed Ansaloni, Luca Adesunkanmi, Abdulrashid Kayode Atanasov, Boyko and Augustin, Goran Bala, Miklosh Baraket, Oussama Baral, Suman and Biffl, Walter L. Boermeester, Marja A. Ceresoli, Marco and Cerutti, Elisabetta Chiara, Osvaldo Cicuttin, Enrico and Chiarugi, Massimo Coimbra, Raul Colak, Elif Corsi, Daniela and Cortese, Francesco Cui, Yunfeng Damaskos, Dimitris and Angelis, Nicola De' Delibegovic, Samir Demetrashvili, Zaza and De Simone, Belinda de Jonge, Stijn W. Dhingra, Sameer Di Bella, Stefano Di Marzo, Francesco Di Saverio, Salomone and Dogjani, Agron Duane, Therese M. Enani, Mushira Abdulaziz and Fugazzola, Paola Galante, Joseph M. Gachabayov, Mahir and Ghnnam, Wagih Gkiokas, George Gomes, Carlos Augusto and Griffiths, Ewen A. Hardcastle, Timothy C. Hecker, Andreas and Herzog, Torsten Kabir, Syed Mohammad Umar Karamarkovic, Aleksandar Khokha, Vladimir Kim, Peter K. Il Kim, Jae and Kirkpatrick, Andrew W. Kong, Victor Koshy, Renol M. and Kryvoruchko, Igor A. Inaba, Kenji Isik, Arda Iskandar, Katia and Ivatury, Rao Labricciosa, Francesco M. Lee, Yeong Yeh and Leppaniemi, Ari Litvin, Andrey Luppi, Davide Machain, Gustavo M. Maier, V, Ronald Marinis, Athanasios Marmorale, Cristina Marwah, Sanjay Mesina, Cristian Moore, Ernest E. and Moore, Frederick A. Negoi, Ionut Olaoye, Iyiade Ordonez, Carlos A. Ouadii, Mouaqit Peitzman, Andrew B. Perrone, Gennaro Pikoulis, Manos Pintar, Tadeja Pipitone, Giuseppe and Podda, Mauro Rasa, Kemal Ribeiro, Julival Rodrigues, Gabriel Rubio-Perez, Ines Sall, Ibrahima Sato, Norio and Sawyer, Robert G. Lohse, Helmut Segovia Sganga, Gabriele and Shelat, Vishal G. Stephens, Ian Sugrue, Michael Tarasconi, Antonio Tochie, Joel Noutakdie Tolonen, Matti Tomadze, Gia and Ulrych, Jan Vereczkei, Andras Viaggi, Bruno Gurioli, Chiara Casella, Claudio Pagani, Leonardo Baiocchi, Gian Luca and Catena, Fausto
- Subjects
embryonic structures - Abstract
Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in hospitals worldwide. The cornerstones of effective treatment of IAIs include early recognition, adequate source control, appropriate antimicrobial therapy, and prompt physiologic stabilization using a critical care environment, combined with an optimal surgical approach. Together, the World Society of Emergency Surgery (WSES), the Global Alliance for Infections in Surgery (GAIS), the Surgical Infection Society-Europe (SIS-E), the World Surgical Infection Society (WSIS), and the American Association for the Surgery of Trauma (AAST) have jointly completed an international multi-society document in order to facilitate clinical management of patients with IAIs worldwide building evidence-based clinical pathways for the most common IAIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting information was shared by an international task force from 46 countries with different clinical backgrounds. The aim of the document is to promote global standards of care in IAIs providing guidance to clinicians by describing reasonable approaches to the management of IAIs.
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- 2021
34. 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy
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DeAngelis, Nicola, Catena, Fausto, Memeo, Riccardo, Coccolini, Federico, Martinez-Perez, Aleix, Romeo, Oreste M., De Simone, Belinda, Di Saverio, Salomone, Brustia, Raffaele, Rhaiem, Rami, Piardi, Tullio, Conticchio, Maria, Marchegiani, Francesco, Beghdadi, Nassiba, Abu-Zidan, Fikri M., Alikhanov, Ruslan, Allard, Marc-Antoine, Allievi, Niccolo, Amaddeo, Giuliana, Ansaloni, Luca, Andersson, Roland, Andolfi, Enrico, Azfar, Mohammad, Bala, Miklosh, Benkabbou, Amine, Ben-Ishay, Offir, Bianchi, Giorgio, Biffl, Walter L., Brunetti, Francesco, Carra, Maria Clotilde, Casanova, Daniel, Celentano, Valerio, Ceresoli, Marco, Chiara, Osvaldo, Cimbanassi, Stefania, Bini, Roberto, Coimbra, Raul, Luigi deAngelis, Gianm, Decembrino, Francesco, De Palma, Andrea, de Reuver, Philip R., Domingo, Carlos, Cotsoglou, Christian, Ferrero, Alessandro, Fraga, Gustavo P., Gaiani, Federica, Gheza, Federico, Gurrado, Angela, Harrison, Ewen, Henriquez, Angel, Hofmeyr, Stefan, Iadarola, Roberta, Kashuk, Jeffry L., Kianmanesh, Reza, Kirkpatrick, Andrew W., Kluger, Yoram, Landi, Filippo, Langella, Serena, Lapointe, Real, Le Roy, Bertrand, Luciani, Alain, Machado, Fernando, Maggi, Umberto, Maier, Ronald V., Mefire, Alain Chichom, Hiramatsu, Kazuhiro, Ordonez, Carlos, Patrizi, Franca, Planells, Manuel, Peitzman, Andrew B., Pekolj, Juan, Perdigao, Fabiano, Pereira, Bruno M., Pessaux, Patrick, Pisano, Michele, Puyana, Juan Carlos, Rizoli, Sandro, Portigliotti, Luca, Romito, Raffaele, Sakakushev, Boris, Sanei, Behnam, Scatton, Olivier, Serradilla-Martin, Mario, Schneck, Anne-Sophie, Sissoko, Mohammed Lamine, Sobhani, Iradj, ten Broek, Richard P., Testini, Mario, Valinas, Roberto, Veloudis, Giorgos, Vitali, Giulio Cesare, Weber, Dieter, Zorcolo, Luigi, Giuliante, Felice, Gavriilidis, Paschalis, Fuks, David, Sommacale, Daniele, DeAngelis, Nicola, Catena, Fausto, Memeo, Riccardo, Coccolini, Federico, Martinez-Perez, Aleix, Romeo, Oreste M., De Simone, Belinda, Di Saverio, Salomone, Brustia, Raffaele, Rhaiem, Rami, Piardi, Tullio, Conticchio, Maria, Marchegiani, Francesco, Beghdadi, Nassiba, Abu-Zidan, Fikri M., Alikhanov, Ruslan, Allard, Marc-Antoine, Allievi, Niccolo, Amaddeo, Giuliana, Ansaloni, Luca, Andersson, Roland, Andolfi, Enrico, Azfar, Mohammad, Bala, Miklosh, Benkabbou, Amine, Ben-Ishay, Offir, Bianchi, Giorgio, Biffl, Walter L., Brunetti, Francesco, Carra, Maria Clotilde, Casanova, Daniel, Celentano, Valerio, Ceresoli, Marco, Chiara, Osvaldo, Cimbanassi, Stefania, Bini, Roberto, Coimbra, Raul, Luigi deAngelis, Gianm, Decembrino, Francesco, De Palma, Andrea, de Reuver, Philip R., Domingo, Carlos, Cotsoglou, Christian, Ferrero, Alessandro, Fraga, Gustavo P., Gaiani, Federica, Gheza, Federico, Gurrado, Angela, Harrison, Ewen, Henriquez, Angel, Hofmeyr, Stefan, Iadarola, Roberta, Kashuk, Jeffry L., Kianmanesh, Reza, Kirkpatrick, Andrew W., Kluger, Yoram, Landi, Filippo, Langella, Serena, Lapointe, Real, Le Roy, Bertrand, Luciani, Alain, Machado, Fernando, Maggi, Umberto, Maier, Ronald V., Mefire, Alain Chichom, Hiramatsu, Kazuhiro, Ordonez, Carlos, Patrizi, Franca, Planells, Manuel, Peitzman, Andrew B., Pekolj, Juan, Perdigao, Fabiano, Pereira, Bruno M., Pessaux, Patrick, Pisano, Michele, Puyana, Juan Carlos, Rizoli, Sandro, Portigliotti, Luca, Romito, Raffaele, Sakakushev, Boris, Sanei, Behnam, Scatton, Olivier, Serradilla-Martin, Mario, Schneck, Anne-Sophie, Sissoko, Mohammed Lamine, Sobhani, Iradj, ten Broek, Richard P., Testini, Mario, Valinas, Roberto, Veloudis, Giorgos, Vitali, Giulio Cesare, Weber, Dieter, Zorcolo, Luigi, Giuliante, Felice, Gavriilidis, Paschalis, Fuks, David, and Sommacale, Daniele
- Abstract
Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estimated incidence of 0.4-1.5%, but considering the number of cholecystectomies performed worldwide, mostly by laparoscopy, surgeons must be prepared to manage this surgical challenge. Most BDIs are recognized either during the procedure or in the immediate postoperative period. However, some BDIs may be discovered later during the postoperative period, and this may translate to delayed or inappropriate treatments. Providing a specific diagnosis and a precise description of the BDI will expedite the decision-making process and increase the chance of treatment success. Subsequently, the choice and timing of the appropriate reconstructive strategy have a critical role in long-term prognosis. Currently, a wide spectrum of multidisciplinary interventions with different degrees of invasiveness is indicated for BDI management. These World Society of Emergency Surgery (WSES) guidelines have been produced following an exhaustive review of the current literature and an international expert panel discussion with the aim of providing evidence-based recommendations to facilitate and standardize the detection and management of BDIs during cholecystectomy. In particular, the 2020 WSES guidelines cover the following key aspects: (1) strategies to minimize the risk of BDI during cholecystectomy; (2) BDI rates in general surgery units and review of surgical practice; (3) how to classify, stage, and report BDI once detected; (4) how to manage an intraoperatively detected BDI; (5) indications for antibiotic treatment; (6) indications for clinical, biochemical, and imaging investigations for suspected BDI; and (7) how to manage a postoperatively detected BDI.
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- 2021
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35. Necrotizing Soft Tissue Infections, the Challenge Remains
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Zorgeenheid Traumatologie, Infection & Immunity, Nawijn, Femke, Hietbrink, Falco, Peitzman, Andrew B., Leenen, Luke P.H., Zorgeenheid Traumatologie, Infection & Immunity, Nawijn, Femke, Hietbrink, Falco, Peitzman, Andrew B., and Leenen, Luke P.H.
- Published
- 2021
36. Technical Challenges and Utility of Anterior Exposure for Thoracic Spine Pathology
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Pettiford, Brian L., Schuchert, Matthew J., Jeyabalan, Geetha, Landreneau, James R., Kilic, Arman, Landreneau, Joshua P., Awais, Omar, Kent, Michael S., Ferson, Peter F., Luketich, James D., Peitzman, Andrew B., and Landreneau, Rodney J.
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- 2008
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37. Additional file 1 of Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines
- Author
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Salomone Di Saverio, Podda, Mauro, Simone, Belinda De, Ceresoli, Marco, Augustin, Goran, Gori, Alice, Boermeester, Marja, Sartelli, Massimo, Coccolini, Federico, Tarasconi, Antonio, Angelis, Nicola De’, Weber, Dieter G., Tolonen, Matti, Birindelli, Arianna, Biffl, Walter, Moore, Ernest E., Kelly, Michael, Soreide, Kjetil, Kashuk, Jeffry, Broek, Richard Ten, Gomes, Carlos Augusto, Sugrue, Michael, Davies, Richard Justin, Damaskos, Dimitrios, Leppäniemi, Ari, Kirkpatrick, Andrew, Peitzman, Andrew B., Fraga, Gustavo P., Maier, Ronald V., Coimbra, Raul, Chiarugi, Massimo, Sganga, Gabriele, Pisanu, Adolfo, Angelis, Gian Luigi De’, Tan, Edward, Goor, Harry Van, Pata, Francesco, Carlo, Isidoro Di, Chiara, Osvaldo, Litvin, Andrey, Campanile, Fabio C., Sakakushev, Boris, Tomadze, Gia, Demetrashvili, Zaza, Latifi, Rifat, Fakri Abu-Zidan, Romeo, Oreste, Segovia-Lohse, Helmut, Baiocchi, Gianluca, Costa, David, Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Scalea, Thomas, Ivatury, Rao, Velmahos, George, Andersson, Roland, Kluger, Yoram, Ansaloni, Luca, and Catena, Fausto
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TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES ,Data_FILES ,Software_PROGRAMMINGLANGUAGES - Abstract
Additional file 1. Search Syntaxes.
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- 2020
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38. Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients
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Liu, Dongmei, primary, Namas, Rami A., additional, Vodovotz, Yoram, additional, Peitzman, Andrew B., additional, Simmons, Richard L., additional, Yuan, Hong, additional, Mi, Qi, additional, and Billiar, Timothy R., additional
- Published
- 2020
- Full Text
- View/download PDF
39. Kidney and uro-trauma: WSES-AAST guidelines
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Coccolini, Federico Moore, Ernest E. Kluger, Yoram Biffl, Walter Leppaniemi, Ari Matsumura, Yosuke Kim, Fernando and Peitzman, Andrew B. Fraga, Gustavo P. Sartelli, Massimo and Ansaloni, Luca Augustin, Goran Kirkpatrick, Andrew and Abu-Zidan, Fikri Wani, Imitiaz Weber, Dieter Pikoulis, Emmanouil Larrea, Martha Arvieux, Catherine Manchev, Vassil and Reva, Viktor Coimbra, Raul Khokha, Vladimir Mefire, Alain Chichom Ordonez, Carlos Chiarugi, Massimo Machado, Fernando Sakakushev, Boris Matsumoto, Junichi Maier, Ron and di Carlo, Isidoro Catena, Fausto Fugazzola, Paola Stommel, Martijn Rajashekar, Mohan Tan, Edward Tolonen, Matti and Ceresoli, Marco Gomez, Carlos Augusto Allievi, Niccolo and Chirica, Mircea Salvetti, Francesco Bertelli, Riccardo and Ben-Ishay, Offir Bahouth, Hany Baiocchi, Gianluca Tarasconi, Antonio Cimbanassi, Stefania Chiara, Osvaldo Ten-Broek, Richard Montori, Giulia Picariello, Erika Solaini, Leonardo and Hecker, Andreas Tomasoni, Matteo Perfetti, Paola Parry, Neil DeAngelis, Nicola Pereira, Bruno M. Bado, Joaquin and Romeo, Oreste Pikoulis, Andreas Bala, Miklosh Napolitano, Lena Galante, Joseph Rizoli, Sandro Ferrada, Paula and Horer, Tal Brenner, Megan Ivatury, Rao WSES-AAST Expert Panel
- Abstract
Renal and urogenital injuries occur in approximately 10-20% of abdominal trauma in adults and children. Optimal management should take into consideration the anatomic injury, the hemodynamic status, and the associated injuries. The management of urogenital trauma aims to restore homeostasis and normal physiology especially in pediatric patients where non-operative management is considered the gold standard. As with all traumatic conditions, the management of urogenital trauma should be multidisciplinary including urologists, interventional radiologists, and trauma surgeons, as well as emergency and ICU physicians. The aim of this paper is to present the World Society of Emergency Surgery (WSES) and the American Association for the Surgery of Trauma (AAST) kidney and urogenital trauma management guidelines.
- Published
- 2019
40. Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO) : 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group
- Author
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Ten Broek, Richard P. G., Krielen, Pepijn, Di Saverio, Salomone, Coccolini, Federico, Biffl, Walter L., Ansaloni, Luca, Velmahos, George C., Sartelli, Massimo, Fraga, Gustavo P., Kelly, Michael D., Moore, Frederick A., Peitzman, Andrew B., Leppaniemi, Ari, Moore, Ernest E., Jeekel, Johannes, Kluger, Yoram, Sugrue, Michael, Balogh, Zsolt J., Bendinelli, Cino, Civil, Ian, Coimbra, Raul, De Moya, Mark, Ferrada, Paula, Inaba, Kenji, Ivatury, Rao, Latifi, Rifat, Kashuk, Jeffry L., Kirkpatrick, Andrew W., Maier, Ron, Rizoli, Sandro, Sakakushev, Boris, Scalea, Thomas, Soreide, Kjetil, Weber, Dieter, Wani, Imtiaz, Abu-Zidan, Fikri M., De'Angelis, Nicola, Piscioneri, Frank, Galante, Joseph M., Catena, Fausto, van Goor, Harry, II kirurgian klinikka, Department of Surgery, Clinicum, and HUS Abdominal Center
- Subjects
Laparotomy ,Adhesions ,GENERAL-SURGERY ,ICODEXTRIN 4-PERCENT SOLUTION ,Small bowel obstruction ,POSTOPERATIVE ADHESIONS ,LAPAROSCOPIC MANAGEMENT ,3126 Surgery, anesthesiology, intensive care, radiology ,SOLUBLE CONTRAST AGENT ,QUALITY-OF-LIFE ,LOWER ABDOMINAL-SURGERY ,SURGICAL-TREATMENT ,RISK-FACTORS ,Surgery ,Laparoscopy ,INTESTINAL-OBSTRUCTION - Abstract
Background: Adhesive small bowel obstruction (ASBO) is a common surgical emergency, causing high morbidity and even some mortality. The adhesions causing such bowel obstructions are typically the footprints of previous abdominal surgical procedures. The present paper presents a revised version of the Bologna guidelines to evidence-based diagnosis and treatment of ASBO. The working group has added paragraphs on prevention of ASBO and special patient groups. Methods: The guideline was written under the auspices of the World Society of Emergency Surgery by the ASBO working group. A systematic literature search was performed prior to the update of the guidelines to identify relevant new papers on epidemiology, diagnosis, and treatment of ASBO. Literature was critically appraised according to an evidence-based guideline development method. Final recommendations were approved by the workgroup, taking into account the level of evidence of the conclusion. Recommendations: Adhesion formation might be reduced by minimally invasive surgical techniques and the use of adhesion barriers. Non-operative treatment is effective in most patients with ASBO. Contraindications for non-operative treatment include peritonitis, strangulation, and ischemia. When the adhesive etiology of obstruction is unsure, or when contraindications for non-operative management might be present, CT is the diagnostic technique of choice. The principles of non-operative treatment are nil per os, naso-gastric, or long-tube decompression, and intravenous supplementation with fluids and electrolytes. When operative treatment is required, a laparoscopic approach may be beneficial for selected cases of simple ASBO. Younger patients have a higher lifetime risk for recurrent ASBO and might therefore benefit from application of adhesion barriers as both primary and secondary prevention. Discussion: This guideline presents recommendations that can be used by surgeons who treat patients with ASBO. Scientific evidence for some aspects of ASBO management is scarce, in particular aspects relating to special patient groups. Results of a randomized trial of laparoscopic versus open surgery for ASBO are awaited.
- Published
- 2018
41. Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries
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Almahmoud, Khalid, primary, Abboud, Andrew, additional, Namas, Rami A., additional, Zamora, Ruben, additional, Sperry, Jason, additional, Peitzman, Andrew B., additional, Truitt, Michael S., additional, Gaski, Greg E., additional, McKinley, Todd O., additional, Billiar, Timothy R., additional, and Vodovotz, Yoram, additional
- Published
- 2019
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42. Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock
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Hierholzer, Christian, Harbrecht, Brian, Menezes, John M., Kane, John, MacMicking, John, Nathan, Carl F., Peitzman, Andrew B., Billiar, Timothy R., and Tweardy, David J.
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- 1998
43. WSES SM (World Society of Emergency Surgery Summer Meeting) highlights: emergency surgery around the world (Brazil, Finland, USA)
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Catena Fausto, Ansaloni Luca, Peitzman Andrew B, Puyana Juan, Ferrada Paula, Leppanemi Ari, Poggetti Renato, Pinna Antonio D, and Moore Ernest E
- Subjects
Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Emergency surgery is performed in every hospital with a A and E unit all around the world. However it is organized in different ways with different results. Aim of this paper is to present history, current scope, current training program and new politics for training national program of 3 countries of different continents. Brazil, Finland and US emergency surgery models are presented discussing all criticisms showed during the WSES Summer Meeting 2008.
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- 2009
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- View/download PDF
44. The open abdomen in trauma and non-trauma patients : WSES guidelines
- Author
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Coccolini, Federico, Roberts, Derek, Ansaloni, Luca, Ivatury, Rao, Gamberini, Emiliano, Kluger, Yoram, Moore, Ernest E., Coimbra, Raul, Kirkpatrick, Andrew Wallace, Pereira, Bruno M., Montori, Giulia, Ceresoli, Marco, Abu-Zidan, Fikri M., Sartelli, Massimo, Velmahos, George C., Fraga, Gustavo Pereira, Leppaniemi, Ari, Tolonen, Matti, Galante, Joseph, Razek, Tarek, Maier, Ron, Bala, Miklosh, Sakakushev, Boris, Khokha, Vladimir, Malbrain, Manu, Agnoletti, Vanni, Peitzman, Andrew B., Demetrashvili, Zaza, Sugrue, Michael, Di Saverio, Salomone, Martzi, Ingo, Soreide, Kjetil, Biffl, Walter, Ferrada, Paula, Parry, Neil, Montravers, Philippe, Melotti, Rita Maria, Salvetti, Francesco, Valetti, Tino M., Scalea, Thomas, Chiara, Osvaldo, Cimbanassi, Stefania, Kashuk, Jeffry L., Larrea, Martha, Martinez Hernandez, Juan Alberto, Lin, Heng-Fu, Chirica, Mircea, Arvieux, Catherine, Bing, Camilla, Horer, Tal, Simone, Belinda De, Masiakos, Peter T., Reva, Viktor, De Angelis, Nicola, Kike, Kaoru, Balogh, Zsolt J., Fugazzola, Paola, Tomasoni, Matteo, Latifi, Rifat, Naidoo, Noel, Weber, Dieter, Handolin, Lauri, Inaba, Kenji, Hecker, Andreas, Yuan, Kuo-Ching, Ordoñez, Carlos A., Rizoli, Sandro, Gomes, Carlos Augusto, De Moya, Marc, Wani, Imtiaz, Mefire, Alain Chichom, Boffard, Ken, Napolitano, Lena, Catena, Fausto, Coccolini, Federico, Roberts, Derek, Ansaloni, Luca, Ivatury, Rao, Gamberini, Emiliano, Kluger, Yoram, Moore, Ernest E., Coimbra, Raul, Kirkpatrick, Andrew Wallace, Pereira, Bruno M., Montori, Giulia, Ceresoli, Marco, Abu-Zidan, Fikri M., Sartelli, Massimo, Velmahos, George C., Fraga, Gustavo Pereira, Leppaniemi, Ari, Tolonen, Matti, Galante, Joseph, Razek, Tarek, Maier, Ron, Bala, Miklosh, Sakakushev, Boris, Khokha, Vladimir, Malbrain, Manu, Agnoletti, Vanni, Peitzman, Andrew B., Demetrashvili, Zaza, Sugrue, Michael, Di Saverio, Salomone, Martzi, Ingo, Soreide, Kjetil, Biffl, Walter, Ferrada, Paula, Parry, Neil, Montravers, Philippe, Melotti, Rita Maria, Salvetti, Francesco, Valetti, Tino M., Scalea, Thomas, Chiara, Osvaldo, Cimbanassi, Stefania, Kashuk, Jeffry L., Larrea, Martha, Martinez Hernandez, Juan Alberto, Lin, Heng-Fu, Chirica, Mircea, Arvieux, Catherine, Bing, Camilla, Horer, Tal, Simone, Belinda De, Masiakos, Peter T., Reva, Viktor, De Angelis, Nicola, Kike, Kaoru, Balogh, Zsolt J., Fugazzola, Paola, Tomasoni, Matteo, Latifi, Rifat, Naidoo, Noel, Weber, Dieter, Handolin, Lauri, Inaba, Kenji, Hecker, Andreas, Yuan, Kuo-Ching, Ordoñez, Carlos A., Rizoli, Sandro, Gomes, Carlos Augusto, De Moya, Marc, Wani, Imtiaz, Mefire, Alain Chichom, Boffard, Ken, Napolitano, Lena, and Catena, Fausto
- Abstract
Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome. These conditions may result in a vicious, self-perpetuating cycle leading to severe physiologic derangements and multiorgan failure unless interrupted by abdominal (surgical or other) decompression. Further, in some clinical situations, the abdomen cannot be closed due to the visceral edema, the inability to control the compelling source of infection or the necessity to re-explore (as a “planned second-look” laparotomy) or complete previously initiated damage control procedures or in cases of abdominal wall disruption. The open abdomen in trauma and non-trauma patients has been proposed to be effective in preventing or treating deranged physiology in patients with severe injuries or critical illness when no other perceived options exist. Its use, however, remains controversial as it is resource consuming and represents a non-anatomic situation with the potential for severe adverse effects. Its use, therefore, should only be considered in patients who would most benefit from it. Abdominal fascia-to-fascia closure should be done as soon as the patient can physiologically tolerate it. All precautions to minimize complications should be implemented.
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- 2018
45. Pelvic trauma : WSES classification and guidelines
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Coccolini, Federico, Stahel, Philip F., Montori, Giulia, Biffl, Walter, Horer, Tal M., Catena, Fausto, Kluger, Yoram, Moore, Ernest E., Peitzman, Andrew B., Ivatury, Rao, Coimbra, Raul, Fraga, Gustavo Pereira, Pereira, Bruno, Rizoli, Sandro, Kirkpatrick, Andrew, Leppäniemi, Ari, Manfredi, Roberto, Magnone, Stefano, Chiara, Osvaldo, Solaini, Leonardo, Ceresoli, Marco, Allievi, Niccolo, Arvieux, Catherine, Velmahos, George, Balogh, Zsolt, Naidoo, Noel, Weber, Dieter, Abu-Zidan, Fikri, Sartelli, Massimo, Ansaloni, Luca, II kirurgian klinikka, Clinicum, Department of Surgery, and HUS Abdominal Center
- Subjects
ABO ,Angiography ,Injury ,REBOA ,Guidelines ,Internal fixation ,HEMODYNAMICALLY UNSTABLE PATIENTS ,TRANSFORAMINAL SACRAL FRACTURES ,RING INJURIES ,3126 Surgery, anesthesiology, intensive care, radiology ,Trauma ,Preperitoneal pelvic packing ,Management ,X-ray ,External fixation ,NONCOMPRESSIBLE TORSO HEMORRHAGE ,ENDOVASCULAR BALLOON OCCLUSION ,Mechanic ,RANDOMIZED-CLINICAL-TRIAL ,Pelvic ring fractures ,C-CLAMP ,BLUNT TRAUMA ,AORTA REBOA ,DAMAGE CONTROL ORTHOPEDICS ,Pelvic - Abstract
Complex pelvic injuries are among the most dangerous and deadly trauma related lesions. Different classification systems exist, some are based on the mechanism of injury, some on anatomic patterns and some are focusing on the resulting instability requiring operative fixation. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic impairment of pelvic ring function and the associated injuries. The management of pelvic trauma patients aims definitively to restore the homeostasis and the normal physiopathology associated to the mechanical stability of the pelvic ring. Thus the management of pelvic trauma must be multidisciplinary and should be ultimately based on the physiology of the patient and the anatomy of the injury. This paper presents the World Society of Emergency Surgery (WSES) classification of pelvic trauma and the management Guidelines.
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- 2017
46. 2017 WSES guidelines for the management of iatrogenic colonoscopy perforation
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de’Angelis, Nicola, primary, Di Saverio, Salomone, additional, Chiara, Osvaldo, additional, Sartelli, Massimo, additional, Martínez-Pérez, Aleix, additional, Patrizi, Franca, additional, Weber, Dieter G., additional, Ansaloni, Luca, additional, Biffl, Walter, additional, Ben-Ishay, Offir, additional, Bala, Miklosh, additional, Brunetti, Francesco, additional, Gaiani, Federica, additional, Abdalla, Solafah, additional, Amiot, Aurelien, additional, Bahouth, Hany, additional, Bianchi, Giorgio, additional, Casanova, Daniel, additional, Coccolini, Federico, additional, Coimbra, Raul, additional, de’Angelis, Gian Luigi, additional, De Simone, Belinda, additional, Fraga, Gustavo P., additional, Genova, Pietro, additional, Ivatury, Rao, additional, Kashuk, Jeffry L., additional, Kirkpatrick, Andrew W., additional, Le Baleur, Yann, additional, Machado, Fernando, additional, Machain, Gustavo M., additional, Maier, Ronald V., additional, Chichom-Mefire, Alain, additional, Memeo, Riccardo, additional, Mesquita, Carlos, additional, Salamea Molina, Juan Carlos, additional, Mutignani, Massimiliano, additional, Manzano-Núñez, Ramiro, additional, Ordoñez, Carlos, additional, Peitzman, Andrew B., additional, Pereira, Bruno M., additional, Picetti, Edoardo, additional, Pisano, Michele, additional, Puyana, Juan Carlos, additional, Rizoli, Sandro, additional, Siddiqui, Mohammed, additional, Sobhani, Iradj, additional, ten Broek, Richard P., additional, Zorcolo, Luigi, additional, Carra, Maria Clotilde, additional, Kluger, Yoram, additional, and Catena, Fausto, additional
- Published
- 2018
- Full Text
- View/download PDF
47. Damage Control Management in the Polytrauma Patient
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Pape, Hans-Christoph., editor, Peitzman, Andrew B., editor, Rotondo, Michael F., editor, Giannoudis, Peter V., editor, Pape, Hans-Christoph., editor, Peitzman, Andrew B., editor, Rotondo, Michael F., editor, and Giannoudis, Peter V., editor
- Published
- 2017
48. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis
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Di Saverio, Salomone, Birindelli, Arianna, Kelly, Micheal D., Catena, Fausto, Weber, Dieter G., Sartelli, Massimo, Sugrue, Michael, De Moya, Mark, Gomes, Carlos Augusto, Bhangu, Aneel, Agresta, Ferdinando, Moore, Ernest E., Soreide, Kjetil, Griffiths, Ewen, De Castro, Steve, Kashuk, Jeffry, Kluger, Yoram, Leppaniemi, Ari, Ansaloni, Luca, Andersson, Manne, Coccolini, Federico, Coimbra, Raul, Gurusamy, Kurinchi S., Campanile, Fabio Cesare, Biffl, Walter, Chiara, Osvaldo, Moore, Fred, Peitzman, Andrew B., Fraga, Gustavo P., Costa, David, Maier, Ronald V., Rizoli, Sandro, Balogh, Zsolt J., Bendinelli, Cino, Cirocchi, Roberto, Tonini, Valeria, Piccinini, Alice, Tugnoli, Gregorio, Jovine, Elio, Persiani, Roberto, Biondi, Antonio, Scalea, Thomas, Stahel, Philip, Ivatury, Rao, Velmahos, George, Andersson, Roland, II kirurgian klinikka, Department of Surgery, and Clinicum
- Subjects
UNCOMPLICATED ACUTE APPENDICITIS ,Complicated appendicitis ,RANDOMIZED CONTROLLED-TRIALS ,Non-operative management ,PERFORATED APPENDICITIS ,ILIAC FOSSA PAIN ,PREDICTING ACUTE APPENDICITIS ,Guidelines ,3126 Surgery, anesthesiology, intensive care, radiology ,INFLAMMATORY RESPONSE SCORE ,Consensus Conference ,COMPUTED-TOMOGRAPHY USE ,LAPAROSCOPIC-APPENDECTOMY ,Alvarado Score ,COMPLICATED ACUTE APPENDICITIS ,Laparoscopic appendectomy ,Acute Appendicitis ,Antibiotics ,LOWER QUADRANT PAIN ,Appendectomy ,Appendicitis diagnosis score ,Appendiceal abscess ,Phlegmon - Abstract
Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several scoring systems proposed for suggesting the probability of AA and the possible subsequent management pathway. The role of imaging in the diagnosis of AA is still debated, with variable use of US, CT and MRI in different settings worldwide. Up to date, comprehensive clinical guidelines for diagnosis and management of AA have never been issued. In July 2015, during the 3rd World Congress of the WSES, held in Jerusalem (Israel), a panel of experts including an Organizational Committee and Scientific Committee and Scientific Secretariat, participated to a Consensus Conference where eight panelists presented a number of statements developed for each of the eight main questions about diagnosis and management of AA. The statements were then voted, eventually modified and finally approved by the participants to The Consensus Conference and lately by the board of co-authors. The current paper is reporting the definitive Guidelines Statements on each of the following topics: 1) Diagnostic efficiency of clinical scoring systems, 2) Role of Imaging, 3) Non-operative treatment for uncomplicated appendicitis, 4) Timing of appendectomy and in-hospital delay, 5) Surgical treatment 6) Scoring systems for intra-operative grading of appendicitis and their clinical usefulness 7) Non-surgical treatment for complicated appendicitis: abscess or phlegmon 8) Pre-operative and post-operative antibiotics.
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- 2016
49. Complete Title: Helicopters and injured kids: Improved survival with scene air medical transport in the pediatric trauma population
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Brown, Joshua B., Leeper, Christine M., Sperry, Jason L., Peitzman, Andrew B., Billiar, Timothy R., Gaines, Barbara A., and Gestring, Mark L.
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Male ,Emergency Medical Services ,Time Factors ,Adolescent ,Multiple Trauma ,Air Ambulances ,Article ,United States ,Time-to-Treatment ,Survival Rate ,Young Adult ,Injury Severity Score ,Transportation of Patients ,Child, Preschool ,Odds Ratio ,Humans ,Female ,Triage ,Child ,Propensity Score ,Follow-Up Studies ,Retrospective Studies - Abstract
Helicopter emergency medical services (HEMS) are frequently used to transport injured children, despite unclear evidence of benefit. The study objective was to evaluate the association of HEMS compared with ground emergency medical services (GEMS) transport with outcomes in a national sample of pediatric trauma patients.Patients 15 years or younger undergoing scene transport by HEMS or GEMS in the National Trauma Data Bank from 2007 to 2012 were included. Propensity score matching was used to match HEMS and GEMS patients for likelihood of HEMS transport based on demographics, prehospital physiology and time, injury severity, and geographic region. Absolute standardized differences of less than 0.1 indicated adequate covariate balance between groups after matching. The primary outcome was in-hospital survival, while the secondary outcome was discharge disposition in survivors. Conditional logistic regression determined the association between HEMS versus GEMS transport with outcomes while controlling for demographics, admission physiology, injury severity, nonaccidental trauma, and in-hospital complications not accounted for in the propensity score. Subgroup analysis was performed in patients with a transport time of greater than 15 minutes to capture patients with the potential for HEMS transport.A total of 25,700 HEMS/GEMS pairs were matched from 166,594 patients. Groups were well matched, with all propensity score variables having absolute standardized differences of less than 0.1. In matched patients, HEMS was associated with a 72% increase in odds of survival compared with GEMS (adjusted odds ratio, 1.72; 95% confidence interval, 1.26-2.36; p0.01). Transport mode was not associated with discharge disposition (p = 0.47). Subgroup analysis included 17,657 HEMS/GEMS pairs. HEMS was again associated with a significant increase in odds of survival (adjusted odds ratio, 1.81; 95% confidence interval, 1.24-2.65; p0.01), while transport mode was not associated with discharge disposition (p = 0.58).Scene transport by HEMS was associated with improved odds of survival compared with GEMS in pediatric trauma patients. Further study is warranted to understand the underlying mechanisms and develop specific triage criteria for HEMS transport in this population.Therapeutic study, level III.
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- 2016
50. Pelvic trauma: WSES classification and guidelines
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Coccolini, Federico, primary, Stahel, Philip F., additional, Montori, Giulia, additional, Biffl, Walter, additional, Horer, Tal M, additional, Catena, Fausto, additional, Kluger, Yoram, additional, Moore, Ernest E., additional, Peitzman, Andrew B., additional, Ivatury, Rao, additional, Coimbra, Raul, additional, Fraga, Gustavo Pereira, additional, Pereira, Bruno, additional, Rizoli, Sandro, additional, Kirkpatrick, Andrew, additional, Leppaniemi, Ari, additional, Manfredi, Roberto, additional, Magnone, Stefano, additional, Chiara, Osvaldo, additional, Solaini, Leonardo, additional, Ceresoli, Marco, additional, Allievi, Niccolò, additional, Arvieux, Catherine, additional, Velmahos, George, additional, Balogh, Zsolt, additional, Naidoo, Noel, additional, Weber, Dieter, additional, Abu-Zidan, Fikri, additional, Sartelli, Massimo, additional, and Ansaloni, Luca, additional
- Published
- 2017
- Full Text
- View/download PDF
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