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1. Comparison of automated segmentation techniques for magnetic resonance images of the prostate

Author

Isaksson, Lars Johannes, Pepa, Matteo, Summers, Paul, Zaffaroni, Mattia, Vincini, Maria Giulia, Corrao, Giulia, Mazzola, Giovanni Carlo, Rotondi, Marco, Lo Presti, Giuliana, Raimondi, Sara, Gandini, Sara, Volpe, Stefania, Haron, Zaharudin, Alessi, Sarah, Pricolo, Paola, Mistretta, Francesco Alessandro, Luzzago, Stefano, Cattani, Federica, Musi, Gennaro, Cobelli, Ottavio De, Cremonesi, Marta, Orecchia, Roberto, Marvaso, Giulia, Petralia, Giuseppe, and Jereczek-Fossa, Barbara Alicja

Published
2023
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2. High-performance prediction models for prostate cancer radiomics

Author

Isaksson, Lars Johannes, Repetto, Marco, Summers, Paul Eugene, Pepa, Matteo, Zaffaroni, Mattia, Vincini, Maria Giulia, Corrao, Giulia, Mazzola, Giovanni Carlo, Rotondi, Marco, Bellerba, Federica, Raimondi, Sara, Haron, Zaharudin, Alessi, Sarah, Pricolo, Paula, Mistretta, Francesco Alessandro, Luzzago, Stefano, Cattani, Federica, Musi, Gennaro, De Cobelli, Ottavio, Cremonesi, Marta, Orecchia, Roberto, La Torre, Davide, Marvaso, Giulia, Petralia, Giuseppe, and Jereczek-Fossa, Barbara Alicja

Published
2023
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3. Quality assurance for automatically generated contours with additional deep learning

Author

Isaksson, Lars Johannes, Summers, Paul, Bhalerao, Abhir, Gandini, Sara, Raimondi, Sara, Pepa, Matteo, Zaffaroni, Mattia, Corrao, Giulia, Mazzola, Giovanni Carlo, Rotondi, Marco, Lo Presti, Giuliana, Haron, Zaharudin, Alessi, Sara, Pricolo, Paola, Mistretta, Francesco Alessandro, Luzzago, Stefano, Cattani, Federica, Musi, Gennaro, De Cobelli, Ottavio, Cremonesi, Marta, Orecchia, Roberto, Marvaso, Giulia, Petralia, Giuseppe, and Jereczek-Fossa, Barbara Alicja

Published
2022
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4. Personalized Setup Optimization Strategies to Improve Clinical Workflow in Image-Guided Pediatric Particle Therapy

Author

Pepa, Matteo, primary, Pella, Andrea, additional, Sellaro, Giulia, additional, Galante, Federica, additional, Mirandola, Alfredo, additional, Ghirelli, Angelica, additional, Vennarini, Sabina, additional, Colombo, Francesca, additional, Imparato, Sara, additional, Iannalfi, Alberto, additional, Ciocca, Mario, additional, Paganelli, Chiara, additional, Orlandi, Ester, additional, and Baroni, Guido, additional

Published
2024
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5. Oligorecurrent Prostate Cancer and Stereotactic Body Radiotherapy: Where Are We Now? A Systematic Review and Meta-analysis of Prospective Studies

Author

Marvaso, Giulia, Volpe, Stefania, Pepa, Matteo, Augugliaro, Matteo, Corrao, Giulia, Biffi, Annalisa, Zaffaroni, Mattia, Bergamaschi, Luca, La Fauci, Francesco Maria, Mistretta, Francesco Alessandro, Luzzago, Stefano, Cattani, Federica, Musi, Gennaro, Petralia, Giuseppe, Pravettoni, Gabriella, De Cobelli, Ottavio, Orecchia, Roberto, and Jereczek-Fossa, Barbara Alicja

Published
2021
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6. Setup Optimization in Ocular Proton Therapy at the National Centre for Oncological Hadrontherapy: Comparison of Two Approaches to Refine the Position of an Eye-Tracking Device

Author

Sellaro, Giulia, primary, Pella, Andrea, additional, Pepa, Matteo, additional, Galante, Federica, additional, Ciocca, Mario, additional, Fiore, Maria Rosaria, additional, Chalaszczyk, Agnieszka, additional, Paganelli, Chiara, additional, Rotondi, Marco, additional, Vai, Alessandro, additional, Orlandi, Ester, additional, and Baroni, Guido, additional

Published
2024
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9. Blood- and Imaging-Derived Biomarkers for Oncological Outcome Modelling in Oropharyngeal Cancer: Exploring the Low-Hanging Fruit

Author

Volpe, Stefania, primary, Gaeta, Aurora, additional, Colombo, Francesca, additional, Zaffaroni, Mattia, additional, Mastroleo, Federico, additional, Vincini, Maria Giulia, additional, Pepa, Matteo, additional, Isaksson, Lars Johannes, additional, Turturici, Irene, additional, Marvaso, Giulia, additional, Ferrari, Annamaria, additional, Cammarata, Giulio, additional, Santamaria, Riccardo, additional, Franzetti, Jessica, additional, Raimondi, Sara, additional, Botta, Francesca, additional, Ansarin, Mohssen, additional, Gandini, Sara, additional, Cremonesi, Marta, additional, Orecchia, Roberto, additional, Alterio, Daniela, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2023
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10. Impact of image filtering and assessment of volume-confounding effects on CT radiomic features and derived survival models in non-small cell lung cancer

Author

Volpe, Stefania, primary, Isaksson, Lars Johannes, additional, Zaffaroni, Mattia, additional, Pepa, Matteo, additional, Raimondi, Sara, additional, Botta, Francesca, additional, Presti, Giuliana Lo, additional, Vincini, Maria Giulia, additional, Rampinelli, Cristiano, additional, Cremonesi, Marta, additional, de Marinis, Filippo, additional, Spaggiari, Lorenzo, additional, Gandini, Sara, additional, Guckenberger, Matthias, additional, Orecchia, Roberto, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2022
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11. Virtual and Augmented Reality as a Novel Opportunity to Unleash the Power of Radiotherapy in the Digital Era: A Scoping Review

Author

Marvaso, Giulia, primary, Pepa, Matteo, additional, Volpe, Stefania, additional, Mastroleo, Federico, additional, Zaffaroni, Mattia, additional, Vincini, Maria Giulia, additional, Corrao, Giulia, additional, Bergamaschi, Luca, additional, Mazzocco, Ketti, additional, Pravettoni, Gabriella, additional, Orecchia, Roberto, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2022
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12. Dosimetric Evaluation of the Inter-Fraction Motion of Organs at Risk in SBRT for Nodal Oligometastatic Prostate Cancer

Author

La Fauci, Francesco, primary, Augugliaro, Matteo, additional, Mazzola, Giovanni Carlo, additional, Comi, Stefania, additional, Pepa, Matteo, additional, Zaffaroni, Mattia, additional, Vincini, Maria Giulia, additional, Corrao, Giulia, additional, Mistretta, Francesco Alessandro, additional, Luzzago, Stefano, additional, Fodor, Cristiana, additional, Musi, Gennaro, additional, Gallo, Salvatore, additional, Petralia, Giuseppe, additional, De Cobelli, Ottavio, additional, Orecchia, Roberto, additional, Cattani, Federica, additional, Marvaso, Giulia, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2022
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14. Establishing a benchmark of diversity, equity, inclusion and workforce engagement in radiation oncology in Europe - an ESTRO collaborative project

Author

Gasnier, Anne, Alicja Jereczek-Fossa, Barbara, Pepa, Matteo, Bagnardi, Vincenzo, Frassoni, Samuele, Perryck, Sophie, Spalek, Mateusz, Petit, Steven F, Bertholet, Jenny, Dubois, Ludwig J, Franco, Pierfrancesco, Gasnier, Anne, Alicja Jereczek-Fossa, Barbara, Pepa, Matteo, Bagnardi, Vincenzo, Frassoni, Samuele, Perryck, Sophie, Spalek, Mateusz, Petit, Steven F, Bertholet, Jenny, Dubois, Ludwig J, and Franco, Pierfrancesco

Abstract

BACKGROUND AND PURPOSE: Diversity, Equity and Inclusion (DEI) in the medical workforce is linked to improved patient care and innovation, as well as employee retention and engagement. The European Society for Radiotherapy and Oncology launched a survey to provide a benchmark of DEI and engagement among radiation oncology (RO) professionals in Europe.METHODS: An anonymous survey was disseminated among RO professionals in Europe. The survey collected demographics and professional information, and participants were asked if they felt they belonged to a minority group. A DEI and workforce engagement questionnaire by Person et al. evaluated 8 inclusion factors. A favourable score was calculated by adding the percentage of "strongly agreed" or "agreed" answers.RESULTS: A total of 812 complete responses were received from 35 European countries. 21% of respondents felt they belonged to a minority group, mostly based on race/ethnicity (5.9%), nationality (4.8%) and age (4.3%). Compared to benchmark data from the United States, scores were lower for most inclusion factors, and to a greater extent for minority groups. The overall favourable score was 58% for those belonging to a minority group, significantly lower than for other respondents (71%, p<0.001). Those belonging to a minority group because of their gender or age had the lowest overall favourable score (47% and 51% respectively).CONCLUSIONS: Our work indicates that actions to improve DEI and workforce engagement among RO professionals in Europe are urgently needed, in particular among minority groups. This would potentially improve employee wellbeing and retention, promoting high quality care and innovation.

Published
2022

15. Impact of image filtering and assessment of volume-confounding effects on CT radiomic features and derived survival models in non-small cell lung cancer

Author

Volpe, Stefania, Isaksson, Lars Johannes, Zaffaroni, Mattia, Pepa, Matteo, Raimondi, Sara, Botta, Francesca, Lo Presti, Giuliana, Vincini, Maria Giulia, Rampinelli, Cristiano, Cremonesi, Marta, de Marinis, Filippo, Spaggiari, Lorenzo, Gandini, Sara, Guckenberger, Matthias, Orecchia, Roberto, Jereczek-Fossa, Barbara Alicja, Volpe, Stefania, Isaksson, Lars Johannes, Zaffaroni, Mattia, Pepa, Matteo, Raimondi, Sara, Botta, Francesca, Lo Presti, Giuliana, Vincini, Maria Giulia, Rampinelli, Cristiano, Cremonesi, Marta, de Marinis, Filippo, Spaggiari, Lorenzo, Gandini, Sara, Guckenberger, Matthias, Orecchia, Roberto, and Jereczek-Fossa, Barbara Alicja

Abstract

BACKGROUND No evidence supports the choice of specific imaging filtering methodologies in radiomics. As the volume of the primary tumor is a well-recognized prognosticator, our purpose is to assess how filtering may impact the feature/volume dependency in computed tomography (CT) images of non-small cell lung cancer (NSCLC), and if such impact translates into differences in the performance of survival modeling. The role of lesion volume in model performances was also considered and discussed. METHODS Four-hundred seventeen CT images NSCLC patients were retrieved from the NSCLC-Radiomics public repository. Pre-processing and features extraction were implemented using Pyradiomics v3.0.1. Features showing high correlation with volume across original and filtered images were excluded. Cox proportional hazards (PH) with least absolute shrinkage and selection operator (LASSO) regularization and CatBoost models were built with and without volume, and their concordance (C-) indices were compared using Wilcoxon signed-ranked test. The Mann Whitney U test was used to assess model performances after stratification into two groups based on low- and high-volume lesions. RESULTS Radiomic models significantly outperformed models built on only clinical variables and volume. However, the exclusion/inclusion of volume did not generally alter the performances of radiomic models. Overall, performances were not substantially affected by the choice of either imaging filter (overall C-index 0.539-0.590 for Cox PH and 0.589-0.612 for CatBoost). The separation of patients with high-volume lesions resulted in significantly better performances in 2/10 and 7/10 cases for Cox PH and CatBoost models, respectively. Both low- and high-volume models performed significantly better with the inclusion of radiomic features (P<0.0001), but the improvement was largest in the high-volume group (+10.2% against +8.7% improvement for CatBoost models and +10.0% against +5.4% in Cox PH models). CONCLUSIONS Rad

Published
2022

16. Stereotactic Radiotherapy Ablation and Atrial Fibrillation: Technical Issues and Clinical Expectations Derived From a Systematic Review

Author

Franzetti, Jessica, primary, Volpe, Stefania, additional, Catto, Valentina, additional, Conte, Edoardo, additional, Piccolo, Consiglia, additional, Pepa, Matteo, additional, Piperno, Gaia, additional, Camarda, Anna Maria, additional, Cattani, Federica, additional, Andreini, Daniele, additional, Tondo, Claudio, additional, Jereczek-Fossa, Barbara Alicja, additional, and Carbucicchio, Corrado, additional

Published
2022
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17. Recent Advances in the Management of Hormone-Sensitive Oligometastatic Prostate Cancer

Author

Marvaso,Giulia, Volpe,Stefania, Pepa,Matteo, Zaffaroni,Mattia, Corrao,Giulia, Augugliaro,Matteo, Nolè,Franco, De Cobelli,Ottavio, and Jereczek-Fossa,Barbara Alicja

Subjects
Cancer Management and Research, digestive system, digestive system diseases
Abstract

Giulia Marvaso,1,2,&ast; Stefania Volpe,1,2,&ast; Matteo Pepa,1,&ast; Mattia Zaffaroni,1,&ast; Giulia Corrao,1,2,&ast; Matteo Augugliaro,1,&ast; Franco Nolè,3,&ast; Ottavio De Cobelli,2,4,&ast; Barbara Alicja Jereczek-Fossa1,2,&ast; 1Division of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy; 2Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy; 3Medical Oncology Division of Urogenital & Head & Neck Tumors, IEO European Institute of Oncology IRCCS, Milan, Italy; 4Department of Urology, IEO, European Institute of Oncology IRCCS, Milan, Italy&ast;These authors contributed equally to this workCorrespondence: Matteo PepaDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, Milan, ItalyEmail matteo.pepa@ieo.itAbstract: After primary treatment for prostate cancer with either radical prostatectomy or radiotherapy, a significant proportion of patients are at risk of developing metastases. In recent years, a deeper understanding of the underlying biology together with improved imaging techniques and the advent of new therapeutic options including metastases-directed therapies and new drugs have revolutionized the management of low-burden metastatic disease, also known as oligometastatic state. The purpose of this narrative review is to report the recent developments in the management of hormone-sensitive oligometastatic prostate cancer patients.Keywords: oligometastatic prostate cancer, metastasis-directed therapies, narrative review, imaging, biology

Published
2022

18. Machine Learning for Head and Neck Cancer: A Safe Bet?—A Clinically Oriented Systematic Review for the Radiation Oncologist

Author

Volpe, Stefania, primary, Pepa, Matteo, additional, Zaffaroni, Mattia, additional, Bellerba, Federica, additional, Santamaria, Riccardo, additional, Marvaso, Giulia, additional, Isaksson, Lars Johannes, additional, Gandini, Sara, additional, Starzyńska, Anna, additional, Leonardi, Maria Cristina, additional, Orecchia, Roberto, additional, Alterio, Daniela, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2021
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19. Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300

Author

Marvaso, Giulia, primary, Vischioni, Barbara, additional, Pepa, Matteo, additional, Zaffaroni, Mattia, additional, Volpe, Stefania, additional, Patti, Filippo, additional, Bellerba, Federica, additional, Gandini, Sara, additional, Comi, Stefania, additional, Corrao, Giulia, additional, Zerini, Dario, additional, Augugliaro, Matteo, additional, Fodor, Cristiana, additional, Russo, Stefania, additional, Molinelli, Silvia, additional, Ciocca, Mario, additional, Ricotti, Rosalinda, additional, Valvo, Francesca, additional, Giandini, Tommaso, additional, Avuzzi, Barbara, additional, Valdagni, Riccardo, additional, De Cobelli, Ottavio, additional, Cattani, Federica, additional, Orlandi, Ester, additional, Jereczek-Fossa, Barbara Alicja, additional, and Orecchia, Roberto, additional

Published
2021
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20. Dosimetric Impact of Inter-Fraction Anatomical Changes in Carbon Ion Boost Treatment for High-Risk Prostate Cancer (AIRC IG 14300)

Author

Russo, Stefania, primary, Ricotti, Rosalinda, additional, Molinelli, Silvia, additional, Patti, Filippo, additional, Barcellini, Amelia, additional, Mastella, Edoardo, additional, Pella, Andrea, additional, Paganelli, Chiara, additional, Marvaso, Giulia, additional, Pepa, Matteo, additional, Comi, Stefania, additional, Zaffaroni, Mattia, additional, Avuzzi, Barbara, additional, Giandini, Tommaso, additional, Pignoli, Emanuele, additional, Valdagni, Riccardo, additional, Baroni, Guido, additional, Cattani, Federica, additional, Ciocca, Mario, additional, Jereczek-Fossa, Barbara Alicja, additional, Orlandi, Ester, additional, Orecchia, Roberto, additional, and Vischioni, Barbara, additional

Published
2021
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21. Therapeutic Sequences in the Treatment of High-Risk Prostate Cancer: Paving the Way Towards Multimodal Tailored Approaches

Author

Marvaso, Giulia, primary, Corrao, Giulia, additional, Zaffaroni, Mattia, additional, Pepa, Matteo, additional, Augugliaro, Matteo, additional, Volpe, Stefania, additional, Musi, Gennaro, additional, Luzzago, Stefano, additional, Mistretta, Francesco Alessandro, additional, Verri, Elena, additional, Cossu Rocca, Maria, additional, Ferro, Matteo, additional, Petralia, Giuseppe, additional, Nolè, Franco, additional, De Cobelli, Ottavio, additional, Orecchia, Roberto, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2021
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22. Exploring miRNA Signature and Other Potential Biomarkers for Oligometastatic Prostate Cancer Characterization: The Biological Challenge behind Clinical Practice. A Narrative Review

Author

Corrao, Giulia, primary, Zaffaroni, Mattia, additional, Bergamaschi, Luca, additional, Augugliaro, Matteo, additional, Volpe, Stefania, additional, Pepa, Matteo, additional, Bonizzi, Giuseppina, additional, Pece, Salvatore, additional, Amodio, Nicola, additional, Mistretta, Francesco Alessandro, additional, Luzzago, Stefano, additional, Musi, Gennaro, additional, Alessi, Sarah, additional, La Fauci, Francesco Maria, additional, Tordonato, Chiara, additional, Tosoni, Daniela, additional, Cattani, Federica, additional, Gandini, Sara, additional, Petralia, Giuseppe, additional, Pravettoni, Gabriella, additional, De Cobelli, Ottavio, additional, Viale, Giuseppe, additional, Orecchia, Roberto, additional, Marvaso, Giulia, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2021
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23. Oligorecurrent Prostate Cancer and Stereotactic Body Radiotherapy: Where Are We Now? A Systematic Review and Meta-analysis of Prospective Studies

Author

Marvaso, G, Volpe, S, Pepa, M, Augugliaro, M, Corrao, G, Biffi, A, Zaffaroni, M, Bergamaschi, L, La Fauci, F, Mistretta, F, Luzzago, S, Cattani, F, Musi, G, Petralia, G, Pravettoni, G, De Cobelli, O, Orecchia, R, Jereczek-Fossa, B, Marvaso, Giulia, Volpe, Stefania, Pepa, Matteo, Augugliaro, Matteo, Corrao, Giulia, Biffi, Annalisa, Zaffaroni, Mattia, Bergamaschi, Luca, La Fauci, Francesco Maria, Mistretta, Francesco Alessandro, Luzzago, Stefano, Cattani, Federica, Musi, Gennaro, Petralia, Giuseppe, Pravettoni, Gabriella, De Cobelli, Ottavio, Orecchia, Roberto, Jereczek-Fossa, Barbara Alicja, Marvaso, G, Volpe, S, Pepa, M, Augugliaro, M, Corrao, G, Biffi, A, Zaffaroni, M, Bergamaschi, L, La Fauci, F, Mistretta, F, Luzzago, S, Cattani, F, Musi, G, Petralia, G, Pravettoni, G, De Cobelli, O, Orecchia, R, Jereczek-Fossa, B, Marvaso, Giulia, Volpe, Stefania, Pepa, Matteo, Augugliaro, Matteo, Corrao, Giulia, Biffi, Annalisa, Zaffaroni, Mattia, Bergamaschi, Luca, La Fauci, Francesco Maria, Mistretta, Francesco Alessandro, Luzzago, Stefano, Cattani, Federica, Musi, Gennaro, Petralia, Giuseppe, Pravettoni, Gabriella, De Cobelli, Ottavio, Orecchia, Roberto, and Jereczek-Fossa, Barbara Alicja

Abstract

Context: The optimal management of oligometastatic prostate cancer (PCa) is still debated. Objective: The purpose of the present systematic review and meta-analysis is to collect the available evidence to date to better define the role of stereotactic body radiotherapy (SBRT) in selected patients with oligorecurrent PCa. Evidence acquisition: Study methodology complied with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). All prospective studies including PCa patients with nodal and/or bone oligometastases (one to five lesions) were considered eligible. Heterogeneity between study-specific estimates was tested using chi-square statistics and measured with the I2 index. A pooled estimate was obtained by fitting both fixed-effect and DerSimonian and Laird random-effect model. Evidence synthesis: Overall, six works (two randomized and the remainder observational) published between 2013 and 2020 were considered eligible. Globally, data from 445 patients were incorporated, of whom 396 were treated with SBRT (329 in observational studies and the remaining 67 in randomized ones). Regarding local progression-free survival (PFS), five studies reported values close to 100%, while one reported a value of 80% in the observation arm. The benefit in terms of biochemical PFS brought by SBRT was evident in all considered studies. Such a difference in cumulative probabilities between the intervention arm and the comparator arm is maintained even 24 mo after the baseline. All studies but one considered toxicity among the endpoints of interest. Most events were classified as either G1 or G2, and the only G ≥ 3 adverse event was reported in one trial. Conclusions: SBRT is highly cost effective, safe, and with an almost inexistent toxicity risk that makes it the perfect candidate for the optimal management of PCa oligometastatic patients. However, more solid data and a higher level of evidence are needed to affirm its role in the management of these patie

Published
2021

24. Machine Learning-Based Models for Prediction of Toxicity Outcomes in Radiotherapy

Author

Isaksson, Lars J., primary, Pepa, Matteo, additional, Zaffaroni, Mattia, additional, Marvaso, Giulia, additional, Alterio, Daniela, additional, Volpe, Stefania, additional, Corrao, Giulia, additional, Augugliaro, Matteo, additional, Starzyńska, Anna, additional, Leonardi, Maria C., additional, Orecchia, Roberto, additional, and Jereczek-Fossa, Barbara A., additional

Published
2020
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25. The emerging role of radiation therapists in the contouring of organs at risk in radiotherapy: analysis of inter-observer variability with radiation oncologists for the chest and upper abdomen

Author

Arculeo, Simona, primary, Miglietta, Eleonora, additional, Nava, Fabrizio, additional, Morra, Anna, additional, Leonardi, Maria Cristina, additional, Comi, Stefania, additional, Ciardo, Delia, additional, Sarra Fiore, Massimo, additional, Gerardi, Marianna Alessandra, additional, Pepa, Matteo, additional, Gugliandolo, Simone Giovanni, additional, Livi, Lorenzo, additional, Orecchia, Roberto, additional, Jereczek-Fossa, Barbara Alicja, additional, and Dicuonzo, Samantha, additional

Published
2020
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