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Your search keyword '"Perez, Geovanny F."' showing total 24 results
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24 results on '"Perez, Geovanny F."'

9. Airway Remodeling Factors During Early-Life Rhinovirus Infection and the Effect of Premature Birth

Author

XuChen, Xilei, primary, Weinstock, Jered, additional, Arroyo, Maria, additional, Salka, Kyle, additional, Chorvinsky, Elizabeth, additional, Abutaleb, Karima, additional, Aguilar, Hector, additional, Kahanowitch, Ryan, additional, Rodríguez-Martínez, Carlos E., additional, Perez, Geovanny F., additional, Gutierrez, Maria J., additional, and Nino, Gustavo, additional

Published
2021
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10. Phenotypical sub-setting of the first episode of severe viral respiratory infection based on clinical assessment and underlying airway disease: a pilot study

Author

Arroyo, Maria A., Salka, Kyle P., Perez, Geovanny F., Rodríguez-Martínez, Carlos E., Castro-Rodriguez, Jose A., Gutierrez, Maria Jimena, and Niño, Gustavo

Subjects
Wheezing, Pediatría, Infecciones del sistema respiratorio, Cytokines, Bronquiolitis, Respiratory viral
Abstract

Introduction: Viral bronchiolitis is a term often used to group all infants with the first episode of severe viral respiratory infection. However, this term encompasses a collection of different clinical and biological processes. We hypothesized that the first episode of severe viral respiratory infection in infants can be subset into clinical phenotypes with distinct outcomes and underlying airway disease patterns. Methods: We included children (≤2 years old) hospitalized for the first time due to PCR-confirmed viral respiratory infection. All cases were categorized based on primary manifestations (wheezing, sub-costal retractions and hypoxemia) into mild, hypoxemia or wheezing phenotypes. We characterized these phenotypes using lung-X-rays, respiratory outcomes and nasal protein levels of antiviral and type 2 cytokines (IFNγ, IL-10, IL-4, IL-13, IL-1β, and TNFα). Results: A total of 50 young children comprising viral respiratory infection cases (n = 41) and uninfected controls (n = 9) were included. We found that 22% of viral respiratory infection cases were classified as mild (n = 9), 39% as hypoxemia phenotype (n = 16) and 39% as wheezing phenotype (n = 16). Individuals in the hypoxemia phenotype had more lung opacities, higher probability of PICU admission and prolonged hospitalizations. Subjects in the wheezing phenotype had higher probability of recurrent sick visits. Nasal cytokine profiles showed that individuals with recurrent sick visits in the wheezing phenotype had increased nasal airway levels of type 2 cytokines (IL-13/IL-4). Conclusion: Clinically-based classification of the first episode of severe viral respiratory infection into mild, hypoxemia or wheezing phenotypes provides critical information about respiratory outcomes, lung disease patterns and underlying airway immunobiology.

Published
2020

20. Directional Secretory Response of Double Stranded RNA-Induced Thymic Stromal Lymphopoetin (TSLP) and CCL11/Eotaxin-1 in Human Asthmatic Airways

Author

Nino, Gustavo, primary, Huseni, Shehlanoor, additional, Perez, Geovanny F., additional, Pancham, Krishna, additional, Mubeen, Humaira, additional, Abbasi, Aleeza, additional, Wang, Justin, additional, Eng, Stephen, additional, Colberg-Poley, Anamaris M., additional, Pillai, Dinesh K., additional, and Rose, Mary C., additional

Published
2014
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23. Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children.

Author

Restrepo-Gualteros, Sonia M., Jaramillo-Barberi, Lina E., Gonzalez-Santos, Monica, Rodriguez-Martinez, Carlos E., Perez, Geovanny F., Gutierrez, Maria J., and Nino, Gustavo

Subjects
CYTOMEGALOVIRUS diseases, HIV infections, SOCIAL indicators, IMMUNOCOMPROMISED patients, PNEUMONIA, IMMUNOHISTOCHEMISTRY
Abstract

Cytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2-4.9 years), using current molecular and imaging diagnostic modalities, in combination with respiratory signs and symptoms. The most prominent clinical and laboratory findings included cough (100%), hypoxemia (100%), diffuse adventitious breath sounds (100%) and increased respiratory effort (93%). All patients had abnormal lung images characterized by ground glass opacity/consolidation in 80% of cases. CMV was detected in the lung either by CMV PCR in bronchoalveolar lavage (82% detection rate) or histology/immunohistochemistry in lung biopsy (100% detection rate). CMV caused respiratory failure in 47% of children infected and the overall mortality rate was 13.3%. Conclusion: CMV pneumonia is a potential lethal disease in non-HIV infected children that requires a high-index of suspicion. Common clinical and radiological patterns such as hypoxemia, diffuse adventitious lung sounds and ground-glass pulmonary opacities may allow early identification of CMV lung infection in the pediatric population, which may lead to prompt initiation of antiviral therapy and better clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2014
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24. Age-Related Effect of Viral-Induced Wheezing in Severe Prematurity.

Author

Perez GF, Jain A, Kurdi B, Megalaa R, Pancham K, Huseni S, Isaza N, Rodriguez-Martinez CE, Rose MC, Pillai D, and Nino G

Abstract

Premature children are prone to severe viral respiratory infections in early life, but the age at which susceptibility peaks and disappears for each pathogen is unclear. Methods: A retrospective analysis was performed of the age distribution and clinical features of acute viral respiratory infections in full-term and premature children, aged zero to seven years. Results: The study comprised of a total of 630 hospitalizations (n = 580 children). Sixty-seven percent of these hospitalizations occurred in children born full-term (>37 weeks), 12% in preterm (32-37 weeks) and 21% in severely premature children (<32 weeks). The most common viruses identified were rhinovirus (RV; 60%) and respiratory syncytial virus (RSV; 17%). Age-distribution analysis of each virus identified that severely premature children had a higher relative frequency of RV and RSV in their first three years, relative to preterm or full-term children. Additionally, the probability of RV- or RSV-induced wheezing was higher overall in severely premature children less than three years old. Conclusions: Our results indicate that the vulnerability to viral infections in children born severely premature is more specific for RV and RSV and persists during the first three years of age. Further studies are needed to elucidate the age-dependent molecular mechanisms that underlie why premature infants develop RV- and RSV-induced wheezing in early life., Competing Interests: The authors declare no conflict of interest.

Published
2016
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