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Odontogenic lesions are well described in domestic cats, but published literature describing these lesions in nondomestic felids is limited. This study reports oral lesions in 109 captive, non-domestic felids. Ten cases of odontogenic lesions were diagnosed, including 9 with fibromatous epulis of periodontal ligament origin (FEPLO) and one odontogenic cyst in a cougar. FEPLO was common in lions. FEPLO did not recur after surgical removal in any of the 3 cases for which follow-up information was available. Increased occurrences of oral papillomas in snow leopards and eosinophilic granulomas in tigers were identified, which is consistent with the reported literature. With the exception of oral papillomas in snow leopards and FEPLO in lions, the spectrum of oral lesions in nondomestic felids was similar to what is reported in domestic cats, with squamous cell carcinoma being the most common oral malignancy, and stomatitis/gingivitis/glossitis accounting for approximately one third of all cases. Rare diagnoses with one case each included hemangioma, fibrosarcoma, melanoma, cleft palate, and glossal amyloidosis.

A case of peripheral ossifying fibroma (POF) in the anterior mandible of a 63-year-old woman is described. The 17 x 23 x 16mm nodular mass was sessile, displaced teeth and had a non-ulcerated, pink surface. Due to the variations in radiographic, clinical and pathological appearance, initially the diagnosis of peripheral odontogenic fibroma was reached. Complex nomenclature and variation in clinical, radiological and pathological appearance of POF and similar masses is discussed.

Summary: Fibromatous epulis is a rare tumour in horses which is analogous to the same condition in dogs and peripheral odontogenic fibromas in man. The nomenclature is varied throughout the veterinary literature, but these tumours are most correctly known as peripheral odontogenic fibromas. Although these lesions are benign, they have a high recurrence rate in other species, so wide local excision is important to give the best possible prognosis.

Peripheral ossifying fibromas (POFs) and peripheral odontogenic fibromas (POdFs) appear clinically similar but of different histogenesis. The novel marker SATB2 is involved in regulation of osteoblastic differentiation and phenotype. However, SATB2 expression has not been previously explored in POFs and POdFs. Given the potential for mineralized tissue formation in POFs and POdFs, and to more clarify the phenotype of the lesional cells, this study was aimed to immunohistochemically investigate SATB2 expression in POFs and POdFs. Fourteen cases of POF and POdF (7 cases each) were selected, stained for SATB2 immunohistochemically, and scored according to the percentage of positive lesional cells (0, no staining; 1 +

Background: The incidence and frequency of odontogenic cysts and tumors depends on the different geographic location. Odontogenic cysts and tumors are lesions that arise from the tooth apparatus or its remnants. The purpose of this study was to determine the prevalence of odontogenic cysts and tumors over a period of 5 years 9 months and to compare our results with other published studies. Aim and Objective: The purpose of this study was to evaluate the prevalence of odontogenic cysts and tumors diagnosed at the Department of Oral Pathology, M.M. College of Dental Sciences & Research, Mullana (Ambala) and to compare the results with findings in the literature. Materials and Method: Data of odontogenic cysts and tumors diagnosed during 2014 to 2019 (till September) w4ere collected from the files of the Oral Pathology Department, M.M. College of Dental Sciences & Research, Mullana (Ambala). Results: Out of the total 71 cases of odontogenic cysts, most prevalent odontogenic cysts were found to be radicular cysts (n=42, %= 59.1%), followed by dentigerous cysts (n=17, %=23.9%) and odontogenic keratocyst (n=12, %=16.9%). Among the odontogenic tumors out of 49 cases reported, the most prevalent was ameloblastoma (n=28, %=57.1%) followed by, ameloblastic fibroma (n=06, %=12.2%), odontoma (n=05,%=10.2%), adenomatoid odontogenic tumor (n=03, %=6.1%), peripheral odontogenic fibroma (n=02, %=4.08%), ameloblastic carcinoma (n=02, %=4.08%), odontogenic fibroma (n=02, %=4.08%) and odontogenic myxofibroma (n=01, %=2.04%). The anterior and posterior portion of the body of mandible was the most common site for both odontogenic cysts and tumors. The age group for odontogenic cysts ranged from 07 to 72 years of age, whereas for the odontogenic cysts the range was 10 to 75 years of age. The male to female ratio for the odontogenic cysts was 1:1.2, whereas for the odontogenic tumors it was found to be having more female predilection with the ratio of 1:1.3. Conclusion: The prevalence of odontogenic cysts was similar to that reported in the literature, with incidence of radicular cysts seen most frequently. In case of odontogenic tumors the findings vary to the reported literature with ameloblastoma being more commonly reported.

To present the clinical presence, histopathological features, and management of a rare peripheral odontogenic fibroma (POF) case. A 32-year-old male patient was referred to the clinic complaining of a localized gingival enlargement of the anterior maxillary region. Initial periodontal treatment was delivered and the patient was informed about proper oral hygiene. After the initial periodontal treatment, the lesion was surgically excised while preserving the marginal line. POF was diagnosed based on clinical and histopathological findings. Normal mechanical oral hygiene was established in the postoperative period. No recurrence was observed during this follow-up period, and the patient was included in the maintenance phase. POF was treated with local excision and the prognosis was excellent. Regular follow-ups are very important for such patients after surgery. How to cite this article: Alan R, Can B, Kilinc F. Peripheral Odontogenic Fibroma: A Rare Case Report. Int Dent Res 2018;8(1):45-9. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

The extraosseous/peripheral odontogenic fibroma (E/POF) is a benign mesenchymal odontogenic tumour found on the gingival surface with clinical characteristics identical to those of reactive lesions. A histopathological analysis is the only method for determining the difference between reactive lesions and these neoplastic lesions, whose recurrence potential varies between 38.9% and 50%, highlighting the importance of correct diagnosis. The following report describes an E/POF case with a clear cells component, as well as a long-term follow-up treatment, which we emphasise due to its potential for recurrence.

Gingival growths are one of the most frequently encountered lesions in the oral cavity. A plethora of lesions can be seen having similar clinical presentation, making diagnosis a dilemma. Peripheral odontogenic tumors are rare neoplasms to occur on gingiva, the most common among them being the peripheral odontogenic fibroma (POdF). The POdF is a benign, slow-growing, exophytic lesion. Although considered to have a recurrence potential after excision, the actual recurrence rate is not known due to paucity of reported cases. Presented here is a case of a rare neoplasm mimicking an inflammatory gingival lesion with review of the available literature. How to cite this article Khot K, Deshmane S, Bagri-Manjrekar K, Khot P. Peripheral Odontogenic Fibroma: A Rare Tumor mimicking a Gingival Reactive Lesion. Int J Clin Pediatr Dent 2017;10(1):103-106.

There appears to be similarities between the clinical appearances of different types of gingival overgrowths. The WHO type peripheral odontogenic fibroma (POdF) is an unusual benign odontogenic neoplasma of the gingiva. It is considered to be an extraosseous counterpart of the central odontogenic fibroma (COF). Among all biopsy specimens, POdF comprehend only upto 0.05%. Odontogenic fibromas are rare but still they provide a noteworthy diagnostic and therapeutic challenge. Along with clinical, radiographic appearance, and histologic features, a sound knowledge on biologic behavior of rare gingival overgrowths would ensure an accurate diagnosis of tumor pathology. We present here a case report of POdF that occurred in a young female patient in anterior interdental region displacing the tooth. Platelet rich fibrin (PRF) was used to stimulate soft tissue healing. Two year follow up showed satisfactory healing with no recurrence.

Peripheral odontogenic fIbroma (POF) is a rare odontogenic tumor. It resembles clinically with other peripheral exophytic lesions like pyogenic granuloma, peripheral ossifying fibroma, and peripheral giant cell granuloma. Hence, needs to be differentiated from such other lesions. Histopathological examination being the only diagnostic approach for peripheral odontogenic fibroma, which can provide a basis for treatment and prognosis evaluation. This case report presents a rare clinical case of a 14-year-old female patient with a palatal overgrowth along the maxillary incisors, which was diagnosed as peripheral odontogenic fibroma.

Congenital granular cell epulis (CGCE) is an uncommon lesion of unclear pathogenesis. It occurs predominantly in female newborns with a predilection site of the maxillary alveolar ridge. The mass enlarges prenatally but the growth arrests after birth. Histologically, CGCE is characterized by a proliferation of polygonal cells with eosinophilic, granular cytoplasm and eccentric, bland-appearing nuclei. It closely resembles adult granular cell tumor (GCT) microscopically and S-100 immunostain is often helpful in distinguishing the two (S-100-positive in GCT and S-100-negative in CGCE). Clinically, the lesion should also be distinguished from entities such as infantile myofibroma, rhabdomyoma, melanotic neuroectodermal tumor of infancy, peripheral odontogenic fibroma, and neurofibroma. CGCE demonstrates an excellent prognosis and has not been associated with any syndromes/genetic defects or malignant transformation. Clinicians and pathologists should be familiar with this rare entity and its differential diagnosis for accurate diagnosis and management.

Isolated lesions of gingiva arise in succession to the hyperinflammatory reactions in response to the underlying local irritants. Despite their overlapping clinical and histological features, these lesions are distinctive regarding their biological behavior. Recurrence has been reported after surgical excision because of the incomplete removal of underlying local irritants. This article describes the clinical and histological features of four localized gingival lesions, adding a note on their molecular pathogenesis and surgical management.

Patient: Male, 35-year-old Final Diagnosis: Central odontogenic fibroma Symptoms: Asymptomatic Medication:— Clinical Procedure: Enucleation • surgery removal Specialty: Dentistry Objective: Rare disease Background: Odontogenic fibroma is a rare mesenchymal odontogenic tumor. It can be classified as central odontogenic fibroma (COF) or peripheral odontogenic fibroma (POF) based on clinical features. There are several variants of COF, including amyloid, ossifying, and giant cell. It grows slowly and exhibits painless cortical expansion of the jawbone. Radiographically, COF appears as a radiolucent unilocular or multilocular lesion with well-defined borders. COF may be associated with unerupted or displaced teeth and root resorption. Case Report: A 35-year-old man was referred to our hospital for submandibular swelling. Panoramic radiography and contrast-enhanced computed tomography revealed a unilocular area of bone resorption with a well-defined border and equal enhancement from the canine to first molar on the right side of the mandible. Root resorption of the first premolar and root separation of the first and second premolars were also evident. The lesion was asymptomatic. Histopathological examination of a biopsy of the lesion was suggestive of OF. Enucleation of the tumor, curettage of the bone around the tumor, and extraction of the premolar were then performed. Histopathological examination of the tumor showed fibrous connective tissue with inactive-looking odontogenic epithelial islands and strands, amyloid deposit, intercalation of Langerhans cells into the tumor epithelium, and no calcification. The final diagnosis of amyloid variant of COF was made. The postoperative course is going well. Conclusions: Herein we describe and discuss the clinical, radiological, and pathological features of the amyloid variant of COF. This report will enhance understanding of this extremely rare variant.

Peripheral odontogenic fibroma (POF) is defined as a benign neoplasm of the jaws of odontogenic ectomesenchymal origin. It is considered an uncommon neoplasm that affects patients in a wide age group, with certain predominance in girls and women. It appears as a firm, slow-growing, and usually sessile mass that affects the gingiva, is of firm consistency, and is covered by apparently normal mucosa. The objective of this study was to report a case of FOP in a 17-year-old male patient with a localized gingival swelling in the region of the left canine. It was present for 3 years and had slowly grown, causing displacement of the teeth. Radiography of the involved area did not reveal bone loss. The lesion was removed by surgical excision, and the POF was diagnosed based on clinical and histopathologic findings. Regular follow-ups are very important for such patients after surgery.

The use of the term “fibroma” for any soft-tissue lesion or gingival lesion by general practitioners has led to inadequate diagnosis of quite a few rare entities. The occurrence of gingival lesions in adolescent female patients is a routine clinical finding. The site of occurrence of such a lesion is of prime significance, as the rarity of these lesions is determined by the site and size of the lesion. On the other hand, the dilemma over the diagnosis of peripheral ossifying fibroma (POF) versus peripheral odontogenic fibroma still continues. Commonly used synonyms for POF include calcifying fibroblastic granuloma, peripheral fibroma with calcification, peripheral cementifying fibroma, and calcifying or ossifying fibrous epulis. The present case report deals with the management of a unique case of POF between two maxillary central incisors in an adolescent female child patient, followed up to 2-year postsurgical excision.

Em cães, os neoplasmas na cavidade oral correspondem a cerca de 4 a 6% de todas os neoplasmas e destes, 65% são malignos. Este trabalho teve como objetivo realizar um estudo retrospectivo e reclassificação histológica dos casos de neoplasmas orais em cães diagnosticados no Setor de Patologia Veterinária (SPV) da Universidade Federal do Rio Grande do Sul (UFRGS), entre janeiro de 2004 a dezembro de 2016. Neste período, foram computados 14.222 casos de neoplasmas em cães, 735 eram da cavidade oral, dos quais 379 amostras foram incluídas neste estudo para a revisão histológica atualizada. Os cães SRD (sem raça definida) foram os mais frequentes, seguidos das raças Poodle, Cocker, Labrador e Boxer. A idade variou de um ano a 20 anos, com média de 9,85 anos e predomínio de cães machos. A localização principal foi a gengiva (55,67%), seguida de cavidade oral (região não especificada) (26,12%) e palato (5,8%). O melanoma foi a neoplasia mais frequente (31,93%), seguida pelo fibroma odontogênico periférico (24,01%), o ameloblastoma acantomatoso (15,57%) e o carcinoma de células escamosas. O presente estudo apresenta dados epidemiológicos e histológicos atuais a respeito dos neoplasmas orais em cães no Rio Grande do Sul. In dogs, neoplasms in the oral cavity correspond to about 4 to 6% of all neoplasms and of these, 65% are malignant. The objective of this study was to conduct a retrospective study and histological reclassification of cases of oral neoplasms in dogs diagnosed in the Setor de Patologia Veterinária (SPV) of the Universidade Federal do Rio Grande do Sul (UFRGS), between January 2004 and December 2016. In this period, 14,222 cases of neoplasms were counted in dogs, 735 were from the oral cavity, of which 379 samples were included in this study for the updated histological revision. Mixed-breed dogs were the most frequent, followed by Poodle, Cocker, Labrador and Boxer breeds. The age ranged from one year to 20 years, with a mean of 9.85 years and a predominance of male dogs. The main location was the gingiva (55,67%), followed by oral cavity (unspecified region) (26,12%) and palate (5,8%). Melanoma was the most frequent neoplasm (31.93%), followed by peripheral odontogenic fibroma (24.01%), acanthomatous ameloblastoma (15.57%) and squamous cell carcinoma. The present study supports and promotes current epidemiological and histological data regarding oral neoplasms in dogs in Rio Grande do Sul.

The purpose of the study is to document a rare case of a peripheral odontogenic fibroma with associated cervical and coronal tooth resorption in a 38 year old woman. Histopathological features are described, the clinical management outlined and follow-up observations over 27 years detailed. The exophytic firm lesion, coral pink in appearance, located on the labial aspect of a maxillary right lateral incisor was excised, fixed in formalin and prepared for histological evaluation. The resorption cavity and adjacent soft tissue were treated by the topical application of trichloroacetic acid prior to restoration with a glass-ionomer cement and subsequent root canal treatment. Histologically, the body of the lesion was characterized by the presence of odontogenic epithelium embedded in a mature fibrous stroma. Areas of dystrophic calcification could also be identified. The features were consistent with a diagnosis of a peripheral odontogenic fibroma. The clinical result of treatment assessed 27 years postoperatively showed no evidence of recurrence of the peripheral odontogenic fibroma. External cervical and coronal tooth resorption can, on rare occasions, prove to be a clinical feature associated with peripheral odontogenic fibroma. Treatment of the tumour mass and the resorptive lesion can provide a successful outcome.

El Fibroma Odontogénico Periférico fue definido por la OMS en el año 2005 como una neoplasia benigna rara constituida por tejido fibroso maduro y una cantidad variable de epitelio odontogénico inactivo. Dada su presentación clínica, localización y baja prevalencia suele ser mal diagnosticado como una lesión reaccional. Se presenta un caso clínico de fibroma odontogénico periférico tratado mediante remoción quirúrgica y se realiza una revisión de la bibliografía respecto a la patología con el propósito de esclarecer algunos aspectos de esta lesión, además de incluirla dentro de los posibles diagnósticos diferenciales de lesiones reaccionales gingivales. El objetivo del siguiente artículo es presentar un caso clínico de FOP tratado mediante remoción quirúrgica y aportar en el diagnóstico diferencial de las lesiones reaccionales gingivales. Peripheral odontogenic fibroma was described by the World Health Organization (WHO) in 2005, as a rare benign tumor containing mature fibrous connective tissue with a varying amount of inactive odontogenic epithelium. Though its clinical presentation, localization and low prevalence, it tends to be misdiagnosed as a reactive lesion. We present a case report of a Peripheral Odontogenic Fibroma treated by surgical resection and a narrative review of the literature with the purpose of clarifying different aspects of this lesion besides considering it as a possible differential diagnosis of reactive gingival lesions. The purpose of this article is to present a case report of peripheral odontogenic fibroma treated by surgical resection. Also to contribute to the differential diagnosis of gingival reactive lesions.

Peripheral odontogenic fibroma (POdF) is a rare benign odontogenic neoplasm. It represents the soft tissue counterpart of central odontogenic fibroma. The embryonic source of POdF has been suggested by many as arising from the rest of dental lamina that has persisted in the gingiva following its disintegration. It presents clinically as a firm, slow growing and sessile gingival mass, which is difficult to distinguish with more common inflammatory lesions. Very few cases of recurrence have been documented. It has been stated that histological budding of basal cell layer of the surface squamous epithelium is associated with higher recurrence and the presence of calcification in direct apposition to the epithelial rest is associated with lower recurrence. Hereby, we present a case which histologically exhibited budding of the basal cell layer, which could have been the reason for its recurrence.

Peripheral odontogenic fibroma (POF) is a rare odontogenic tumor. It commonly mimics other peripheral exophytic lesions like pyogenic granuloma, peripheral ossifying fibroma, and peripheral giant cell granuloma. It needs to be differentiated from other lesions by its different clinical behavior.

PERIPHERAL ODONTOGENIC FIBROMA: AN UNUSUAL CASE ABSTRACT Peripheral odontogenic fibroma (POF) is a benign odontogenic neoplasm of fibroblastic origin characterized by relatively mature collagenous fibrous tissue and varying amounts of odontogenic epithelium. The lesions are treated by conservative surgical excision. However, it is considered to be with a potential to recur. This paper presents a peripheral odontogenic fibroma case report and emphasizes the accurate diagnosis and importance of patient follow-up. Keywords: Peripheral odontogenic fibroma, benign neoplazm, periodontal surgery PERIFERIAL ODONTOJENIK FIBROMA: NADIR BIR OLGU OZET Periferal odontojenik fibroma (POF) degisik miktarlarda odontojenik epitel ve kismen olgun kollojenoz fibroz doku icermesiyle karekterize fibroblastik orjinli benign odontojenik neoplazmdir. Lezyonlar konservatif cerrahi eksizyonla tedavi edilir. Bununla birlikte tekrar olusma potansiyeliyle dikkate alinir. Bu makale periferal odontojenik fibroma olgusu takdim etmekte ve dogru tani ve hasta takibinin onemini vurgulamaktadir. Anahtar Kelimeler: Periferial odontojenik fibroma, benign neoplazm, periodontal cerrahi

Central odontogenic fibroma has been defined as a benign odontogenic tumor, representing the intraosseous counterpart of a peripheral odontogenic fibroma. The odontogenic fibroma is a rare tumor. Differential diagnosis of radiolucent lesions in the molar-premolar region of mandible which involve impacted tooth may include central odontogenic fibroma, hyperplastic dental follicle, dentigerous cyst, unicystic ameloblastoma, and keratocystic odontogenic tumor. We describe an example of a small central odontogenic fibroma mimicking hyperplastic dental follicle and dentigerous cyst, resulting in uneruption of a primary tooth.

Objective—To characterize clinicopathologic features of the most common odontogenic tumors and focal fibrous hyperplasia (FFH) in dogs. Design—Retrospective case series. Animals—152 dogs evaluated for oral tumors of possible odontogenic origin at the William R. Pritchard Veterinary Medical Teaching Hospital of the University of California-Davis between 1995 and 2005. Procedures—Information was collected from records, including dog breed, age, reproductive status, and location of lesion in the oral cavity. Histologic slides pertaining to each dog were reviewed by 3 investigators. Data regarding clinicopathologic features of the 3 most common lesions (canine acanthomatous ameloblastoma [CAA], peripheral odontogenic fibroma [POF], and FFH) were summarized. Results—152 dogs with odontogenic tumors or FFH were identified. Sixty-eight (45%) dogs had CAA, 47 (31 %) had POF, 24 (16%) had FFH, and 13 (9%) had other odontogenic tumors. Canine acanthomatous ameloblastoma was present most commonly in the rostral aspect of the mandible, with POF and FFH more common in the rostral aspect of the maxilla. Males and females were equally represented among dogs with CAA and FFH. Castrated males were overrepresented among dogs with POF. Golden Retrievers, Akitas, Cocker Spaniels, and Shetland Sheepdogs were overrepresented among dogs with CAA. No breed predisposition was detected for FFH or POF. Dogs with FFH had a greater mean age at initial evaluation than did dogs with CAA or POF. Conclusions and Clinical Relevance—CAA, POF, and FFH have distinct clinical patterns that may help clinicians and pathologists identify such lesions more readily.

Background/Purpose Odontogenic fibroma (ODF) is a rare odontogenic tumor. It can be further divided into peripheral odontogenic fibroma (PODF) and central odontogenic fibroma (CODF). This retrospective study evaluated the clinical and histopathological features of 15 ODFs in Taiwanese patients. Methods Fifteen consecutive cases of ODF were collected from 1984 to 2009. The clinical data and microscopic features of these cases were reviewed and analyzed. Results Twelve PODFs were excised from six male and six female patients (mean age: 35 years) and three CODFs from two male and one female patients (mean age: 11 years). Eight of the 12 PODFs were found on the mandibular gingiva and four on the maxillary gingiva, with the most common site being the mandibular anterior and premolar region (5 cases). Two CODFs were located in the molar region of the mandible and one in the anterior maxilla. Two CODFs showed a mixed lesion and one a radiolucent lesion. No recurrence of the 15 ODFs was found after total excision or enucleation. Microscopically 58.3% of the PODFs showed surface ulceration. Calcified foci composed of osteoid, cementoid, or cementicle-like materials were noted in all 15 ODFs. Nests or strands of odontogenic epithelium were found in all 15 ODFs. The stromal component was mainly fibro-collagenous in nine of the 12 PODFs, whereas two of the three CODFs contained predominantly myxomatous stroma. Conclusion PODFs occurred more commonly than CODFs. PODF showed an equal sex distribution and was found more frequently in patients in the third to fourth decades of life. The most commonly affected site was the mandibular gingiva, especially the anterior and premolar gingiva. Only three CODFs were found; therefore, we could not draw any conclusions about CODF in Taiwanese patients.

Here, we present a case report of peripheral ossifying fibroma (POF) in an adult lady in her fourth decade of life. This case report comprises the growth that occurred in the mandibular anterior region with displacement of anterior teeth, its satisfactory management and literature review. POF represents a reactive benign lesion of connective tissue and is not the soft tissue counterpart of ossifying fibroma and is also not related anyhow to peripheral odontogenic fibroma. POF in the age of 45 years, arising in the mandibular anterior region, is an occasional entity. Careful clinical examination and histopathology findings should be correlated to conclude the final diagnosis.

) was evaluated because of right-sided facial swelling and a recent history of dysphagia and stridor. The squirrel was anesthetized to allow for phys-ical examination and collection of blood samples. Physical examination revealed a fracture of the maxillary right third premolar tooth and an associated abscess. Results of hematologic and serum biochemical testing were with-in reference limits for this species. While the squirrel was anesthetized, radiographs of the skull were obtained

A case of peripheral odontogenic fibroma occurring in the posterior region of the maxilla in a 7-year-old girl is presented. The patient was referred to our hospital because of a painless swelling in the buccal gingiva at 6 1. Physical examination revealed a localized elastic-hard tumor, with no radiological abnormalities in the adjacent alveolar bone. A biopsy specimen showed proliferation of fibroblastic cells in the submucosal layer. With the patient under general anesthesia, the tumor was resected subperiosteally, and the underlying bone surface was smoothened with a bur. Histologically, the lesion was composed of cellular fibrous connective tissue with scattered regions of cellular strands interwoven with less cellular areas and islands of odontogenic epithelium. The final diagnosis was peripheral odontogenic fibroma. Specific staining demonstrated that the tumor stroma contained large amounts of oxytalan fibers and tenascin. A positive reaction for tenascin was found to be a valuable pathohistological marker that could distinguish between peripheral odontogenic fibroma and calcifying fibrous epulis.As of about 9 years after the operation, there has been no evidence of recurrence.