13 results on '"Pesqueira Fontan, Paula Maria"'
Search Results
2. Influence of chronic use of corticosteroids and calcineurin inhibitors on COVID-19 clinical outcomes: analysis of a nationwide registry
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Calderón-Parra, Jorge, Cuervas-Mons, Valentín, Moreno-Torres, Victor, Rubio-Rivas, Manuel, Blas, Paloma Agudo-de, Pinilla-Llorente, Blanca, Helguera-Amezua, Cristina, Jiménez-García, Nicolás, Pesqueira-Fontan, Paula-María, Méndez-Bailón, Manuel, Artero, Arturo, Gilabert, Noemí, Ibánez-Estéllez, Fátima, Freire-Castro, Santiago-Jesús, Lumbreras-Bermejo, Carlos, and Antón-Santos, Juan-Miguel
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- 2022
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3. Predicting critical illness on initial diagnosis of COVID-19 based on easily obtained clinical variables: development and validation of the PRIORITY model
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Abrego-Vaca, Luis F., Andreu-Arnanz, Ana, Arce-García, Octavio A., Bajo-González, Marta, Borque-Sanz, Pablo, Cózar-Llistó, Alberto, Del Hoyo-Cuenda, Beatriz, Gamboa-Osorio, Alejandra, García-Sánchez, Isabel, López-Cisneros, Óscar A., Merino-Ortiz, Borja, Riera-González, Elisa, Rey-García, Jimena, Sánchez-Díaz, Cristina, Starita-Fajardo, Grisell, Suárez-Carantoña, Cecilia, Zhilina, Svetlana Zhilina, Martínez-Lacalzada, Miguel, Viteri-Noël, Adrián, Manzano, Luis, Fabregate, Martin, Rubio-Rivas, Manuel, Luis García, Sara, Arnalich-Fernández, Francisco, Beato-Pérez, José Luis, Vargas-Núñez, Juan Antonio, Calvo-Manuel, Elpidio, Espiño-Álvarez, Alexia Constanza, Freire-Castro, Santiago J., Loureiro-Amigo, Jose, Pesqueira Fontan, Paula Maria, Pina, Adela, Álvarez Suárez, Ana María, Silva-Asiain, Andrea, García-López, Beatriz, Luque del Pino, Jairo, Sanz-Cánovas, Jaime, Chazarra-Pérez, Paloma, García-García, Gema María, Núñez-Cortés, Jesús Millán, Casas-Rojo, José Manuel, and Gómez-Huelgas, Ricardo
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- 2021
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4. Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy
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Bendala Estrada, Alejandro David, Calderón Parra, Jorge, Fernández Carracedo, Eduardo, Muiño Míguez, Antonio, Ramos Martínez, Antonio, Muñez Rubio, Elena, Rubio-Rivas, Manuel, Agudo, Paloma, Arnalich Fernández, Francisco, Estrada Perez, Vicente, Taboada Martínez, María Luisa, Crestelo Vieitez, Anxela, Pesqueira Fontan, Paula Maria, Bustamante, Marta, Freire, Santiago J., Oriol-Bermúdez, Isabel, Artero, Arturo, Olalla Sierra, Julián, Areses Manrique, María, Carrasco-Sánchez, H. Francisco Javier, Vento, Vanessa Carolina, García García, Gema María, Cubero-Morais, Pablo, Casas-Rojo, José-Manuel, and Núñez-Cortés, Jesús Millán
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- 2021
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5. Grado de control metabólico en pacientes ambulatorios con diabetes mellitus tipo 2 en Medicina Interna. Estudio BARVI
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Pesqueira Fontán, Paula María, Grandes Ibáñez, Jesús, Rodríguez-Gallego López, Carolina, Molinos Castro, Sonia, González Vázquez, Laura, de La Cruz Álvarez, Julio, Puerta Louro, Rubén, Gayol Fernández, María del Carmen, and Díaz Peromingo, José Antonio
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- 2012
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6. Predicting critical illness on initial diagnosis of COVID-19 based on easily obtained clinical variables: development and validation of the PRIORITY model
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Martínez-Lacalzada, Miguel, primary, Viteri-Noël, Adrián, additional, Manzano, Luis, additional, Fabregate, Martin, additional, Rubio-Rivas, Manuel, additional, Luis García, Sara, additional, Arnalich-Fernández, Francisco, additional, Beato-Pérez, José Luis, additional, Vargas-Núñez, Juan Antonio, additional, Calvo-Manuel, Elpidio, additional, Espiño-Álvarez, Alexia Constanza, additional, Freire-Castro, Santiago J., additional, Loureiro-Amigo, Jose, additional, Pesqueira Fontan, Paula Maria, additional, Pina, Adela, additional, Álvarez Suárez, Ana María, additional, Silva-Asiain, Andrea, additional, García-López, Beatriz, additional, Luque del Pino, Jairo, additional, Sanz-Cánovas, Jaime, additional, Chazarra-Pérez, Paloma, additional, García-García, Gema María, additional, Núñez-Cortés, Jesús Millán, additional, Casas-Rojo, José Manuel, additional, Gómez-Huelgas, Ricardo, additional, Abrego-Vaca, Luis F., additional, Andreu-Arnanz, Ana, additional, Arce-García, Octavio A., additional, Bajo-González, Marta, additional, Borque-Sanz, Pablo, additional, Cózar-Llistó, Alberto, additional, Del Hoyo-Cuenda, Beatriz, additional, Gamboa-Osorio, Alejandra, additional, García-Sánchez, Isabel, additional, López-Cisneros, Óscar A., additional, Merino-Ortiz, Borja, additional, Riera-González, Elisa, additional, Rey-García, Jimena, additional, Sánchez-Díaz, Cristina, additional, Starita-Fajardo, Grisell, additional, Suárez-Carantoña, Cecilia, additional, and Zhilina, Svetlana Zhilina, additional
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- 2021
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7. Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain
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Rodilla Sala, Enrique, López Carmona, Maria Dolores, Cortes, Xavi, Cobos Palacios, Lidia, Canales, Sergio, Sáez, Maria Carmen, Campos Escudero, Samara, Rubio-Rivas, Manuel, Díez Manglano, Jesús, Freire Castro, Santiago, Vázquez Piqueras, Nuria, Mateo Sanchis, Elisabeth, Pesqueira Fontan, Paula Maria, Magallanes Gamboa, Jeffrey Oskar, González García, Andrés, Madrid Romero, Victor, Tamargo Chamorro, Lara, González Moraleja, Julio, Villanueva Martínez, Javier, González Noya, Amara, Suárez Lombraña, Ana, Gracia Gutiérrez, Anyuli, López Reboiro, Manuel Lorenzo, Ramos Rincón, José Manuel, Gómez Huelgas, Ricardo, and SEMI-COVID-19 Network
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Male ,heart failure ,Blood Pressure ,Comorbidity ,Kaplan-Meier Estimate ,Insuficiència cardíaca ,030204 cardiovascular system & hematology ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,blood pressure ,Cause of Death ,Epidemiology ,Odds Ratio ,Hospital Mortality ,Registries ,030212 general & internal medicine ,Cause of death ,Aged, 80 and over ,Age Factors ,Middle Aged ,Prognosis ,arterial stiffness ,Cardiovascular diseases ,Cardiovascular Diseases ,Female ,COVID-19 ,hypertension ,medicine.medical_specialty ,Heart failure ,pulse pressure ,03 medical and health sciences ,Vascular Stiffness ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Obesity ,Pandemics ,Aged ,Retrospective Studies ,SARS-CoV-2 ,business.industry ,Malalties cardiovasculars ,Retrospective cohort study ,Original Articles ,Odds ratio ,medicine.disease ,Blood pressure ,Spain ,Arterial stiffness ,business - Abstract
Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) P P =0.0001; ORadj: 1.48, P =0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P =0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P =0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P =0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP
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- 2021
8. Gender-Based Differences by Age Range in Patients Hospitalized with COVID-19: A Spanish Observational Cohort Study
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Josa Laorden, Claudia, Crestelo Vieitez, Anxela, García Andreu, María, Rubio-Rivas, Manuel, Sánchez, Marcos, Toledo Samaniego, Neera, Arnalich Fernández, Francisco, Iguaran Bermudez, Rosario, Fonseca Aizpuru, Eva, Vargas Núñez, Juan Antonio, Pesqueira Fontan, Paula Maria, Serrano Ballesteros, Jorge, Freire Castro, Santiago, Pestaña Fernández, Melani, Viana García, Alba, Nuñez Rodriguez, Victoria, Giner Galvañ, Vicente, Carrasco Sánchez, Francisco, Hernández Milián, Almudena, Cobos Siles, Marta, Napal Lecumberri, Jose, Herrero García, Virginia, Pascual Pérez, Maria, Millán Núñez-Cortés, Jesús, Casas Rojo, José, SEMI-COVID-19 Network, UAM. Departamento de Medicina, and Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)
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medicine.medical_specialty ,Multivariate analysis ,Medicina ,medicine.medical_treatment ,coronavirus ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Lower risk ,Article ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,medicine ,Factors sexuals en les malalties ,030212 general & internal medicine ,Espanya ,Mechanical ventilation ,business.industry ,SARS-CoV-2 ,Mortality rate ,lcsh:R ,COVID-19 ,General Medicine ,Intensive care unit ,gender differences ,Spain ,Sex factors in disease ,Observational study ,Complication ,business ,Cohort study - Abstract
There is some evidence that male gender could have a negative impact on the prognosis and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of the present study was to compare the characteristics of coronavirus disease 2019 (COVID-19) between hospitalized men and women with confirmed SARS-CoV-2 infection. This multicenter, retrospective, observational study is based on the SEMI-COVID-19 Registry. We analyzed the differences between men and women for a wide variety of demographic, clinical, and treatment variables, and the sex distribution of the reported COVID-19 deaths, as well as intensive care unit (ICU) admission by age subgroups. This work analyzed 12,063 patients (56.8% men). The women in our study were older than the men, on average (67.9 vs. 65.7 years; p < 001). Bilateral condensation was more frequent among men than women (31.8% vs. 29.9%; p = 0.007). The men needed non-invasive and invasive mechanical ventilation more frequently (5.6% vs. 3.6%, p < 0.001, and 7.9% vs. 4.8%, p < 0.001, respectively). The most prevalent complication was acute respiratory distress syndrome, with severe cases in 19.9% of men (p < 0.001). In men, intensive care unit admission was more frequent (10% vs. 6.1%; p < 0.001) and the mortality rate was higher (23.1% vs. 18.9%; p < 0.001). Regarding mortality, the differences by gender were statistically significant in the age groups from 55 years to 89 years of age. A multivariate analysis showed that female sex was significantly and independently associated with a lower risk of mortality in our study. Male sex appears to be related to worse progress in COVID-19 patients and is an independent prognostic factor for mortality. In order to fully understand its prognostic impact, other factors associated with sex must be considered.
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- 2021
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9. Inappropriate antibiotic use in the COVID-19 era: Factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID
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Calderón Parra, Jorge, Muiño Míguez, Antonio, Bendala Estrada, Alejandro David, Ramos Martínez, Antonio, Muñez Rubio, Elena, Fernández Carracedo, Eduardo, Tejada Montes, Javier, Rubio-Rivas, Manuel, Arnalich Fernández, Francisco, Beato Pérez, Jose Luis, García Bruñén, Jose Miguel, Corral-Beamonte, Esther del, Pesqueira Fontan, Paula Maria, Carmona, Maria Del Mar, Fernández-Madera Martínez, Rosa, González García, Andrés, Salazar Mosteiro, Cristina, Tuñón de Almeida, Carlota, González Moraleja, Julio, Deodati, Francesco, Martín Escalante, María Dolores, Asensio Tomás, María Luisa, Gómez Huelgas, Ricardo, Casas Rojo, José, Millán Núñez-Cortés, Jesús, and For The Semi-covid-19 Network
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0301 basic medicine ,Male ,Viral Diseases ,Epidemiology ,Physiology ,Antibiotics ,Fevers ,Inappropriate Prescribing ,Comorbidity ,medicine.disease_cause ,Medical Conditions ,0302 clinical medicine ,Risk Factors ,Medicine and Health Sciences ,Coughing ,Odds Ratio ,Medicine ,030212 general & internal medicine ,Registries ,Multidisciplinary ,Antimicrobials ,Drugs ,Acute Kidney Injury ,Middle Aged ,Anti-Bacterial Agents ,Infectious Diseases ,C-Reactive Protein ,Superinfection ,Cohort ,Female ,Research Article ,medicine.medical_specialty ,Fever ,medicine.drug_class ,Science ,Immunology ,030106 microbiology ,Pharmacy practice ,Microbiology ,Autoimmune Diseases ,03 medical and health sciences ,Signs and Symptoms ,Antibiotic resistance ,Microbial Control ,Internal medicine ,Humans ,Medical prescription ,Aged ,Retrospective Studies ,Atenció farmacèutica ,Pharmacology ,business.industry ,SARS-CoV-2 ,Pharmacy--Practice ,Biology and Life Sciences ,COVID-19 ,Covid 19 ,Retrospective cohort study ,Odds ratio ,medicine.disease ,Dyspnea ,Logistic Models ,Cough ,Antibiotic Resistance ,Medical Risk Factors ,Clinical Immunology ,Antimicrobial Resistance ,Clinical Medicine ,Physiological Processes ,business - Abstract
Background Most patients with COVID-19 receive antibiotics despite the fact that bacterial co-infections are rare. This can lead to increased complications, including antibacterial resistance. We aim to analyze risk factors for inappropriate antibiotic prescription in these patients and describe possible complications arising from their use. Methods The SEMI-COVID-19 Registry is a multicenter, retrospective patient cohort. Patients with antibiotic were divided into two groups according to appropriate or inappropriate prescription, depending on whether the patient fulfill any criteria for its use. Comparison was made by means of multilevel logistic regression analysis. Possible complications of antibiotic use were also identified. Results Out of 13,932 patients, 3047 (21.6%) were prescribed no antibiotics, 6116 (43.9%) were appropriately prescribed antibiotics, and 4769 (34.2%) were inappropriately prescribed antibiotics. The following were independent factors of inappropriate prescription: February-March 2020 admission (OR 1.54, 95%CI 1.18–2.00), age (OR 0.98, 95%CI 0.97–0.99), absence of comorbidity (OR 1.43, 95%CI 1.05–1.94), dry cough (OR 2.51, 95%CI 1.94–3.26), fever (OR 1.33, 95%CI 1.13–1.56), dyspnea (OR 1.31, 95%CI 1.04–1.69), flu-like symptoms (OR 2.70, 95%CI 1.75–4.17), and elevated C-reactive protein levels (OR 1.01 for each mg/L increase, 95% CI 1.00–1.01). Adverse drug reactions were more frequent in patients who received ANTIBIOTIC (4.9% vs 2.7%, p < .001). Conclusion The inappropriate use of antibiotics was very frequent in COVID-19 patients and entailed an increased risk of adverse reactions. It is crucial to define criteria for their use in these patients. Knowledge of the factors associated with inappropriate prescribing can be helpful.
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- 2021
10. Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry.
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Carrasco-Sánchez, Francisco Javier, López-Carmona, Mª Dolores, Martínez-Marcos, Francisco Javier, Pérez-Belmonte, Luis M., Hidalgo-Jiménez, Alicia, Buonaiuto, Verónica, Suárez Fernández, Carmen, Freire Castro, Santiago Jesús, Luordo, Davide, Pesqueira Fontan, Paula Maria, Blázquez Encinar, Julio César, Magallanes Gamboa, Jeffrey Oskar, de la Peña Fernández, Andrés, Torres Peña, José David, Fernández Solà, Joaquim, Napal Lecumberri, Jose Javier, Amorós Martínez, Francisco, Guisado Espartero, María Esther, Jorge Ripper, Carlos, and Gómez Méndez, Raquel
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COVID-19 ,DIABETES ,MORTALITY risk factors ,INTENSIVE care units ,HOSPITAL mortality - Abstract
Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: <140 mg/dL, 140–180 mg/dL and >180 mg/dL. The primary endpoint was all-cause in-hospital mortality. Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (<140 mg/dL), 33.7% (140–180 mg) and 41.1% (>180 mg/dL), p<.001. The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia (log rank, p<.001), independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality (BG >180 mg/dL: HR 1.50; 95% confidence interval (CI): 1.31–1.73) (BG 140–180 mg/dL; HR 1.48; 95%CI: 1.29–1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality. Admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes. Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19. Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19. Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes. [ABSTRACT FROM AUTHOR]
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- 2021
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11. The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals.
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Mateos González, María, Sierra Gonzalo, Elena, Casado Lopez, Irene, Arnalich Fernández, Francisco, Beato Pérez, José Luis, Monge Monge, Daniel, Vargas Núñez, Juan Antonio, García Fenoll, Rosa, Suárez Fernández, Carmen, Freire Castro, Santiago Jesús, Mendez Bailon, Manuel, Perales Fraile, Isabel, Madrazo, Manuel, Pesqueira Fontan, Paula Maria, Magallanes Gamboa, Jeffrey Oskar, González García, Andrés, Crestelo Vieitez, Anxela, Fonseca Aizpuru, Eva María, Aranguren Arostegui, Asier, and Coduras Erdozain, Ainara
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COVID-19 ,PROGNOSIS ,BLOOD cell count ,ADULT respiratory distress syndrome ,BLOOD cells - Abstract
Objectives: A decrease in blood cell counts, especially lymphocytes and eosinophils, has been described in patients with serious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but there is no knowledge of their potential role of the recovery in these patients' prognosis. This article aims to analyse the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Design: This work was a retrospective, multicentre cohort study of 9644 hospitalised patients with confirmed COVID-19 from the Spanish Society of Internal Medicine's SEMI-COVID-19 Registry. Setting: This study examined patients hospitalised in 147 hospitals throughout Spain. Participants: This work analysed 9644 patients (57.12% male) out of a cohort of 12,826 patients ≥18 years of age hospitalised with COVID-19 in Spain included in the SEMI-COVID-19 Registry as of 29 May 2020. Main outcome measures: The main outcome measure of this work is the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Univariate analysis was performed to determine possible predictors of death, and then multivariate analysis was carried out to control for potential confounders. Results: An increase in the eosinophil count on the seventh day of hospitalisation was associated with a better prognosis, including lower mortality rates (5.2% vs. 22.6% in non-recoverers, OR 0.234; 95% CI, 0.154 to 0.354) and lower complication rates, especially regarding the development of acute respiratory distress syndrome (8% vs. 20.1%, p = 0.000) and ICU admission (5.4% vs. 10.8%, p = 0.000). Lymphocyte recovery was found to have no effect on prognosis. Treatment with inhaled or systemic glucocorticoids was not found to be a confounding factor. Conclusion: Eosinophil recovery in patients with COVID-19 who required hospitalisation had an independent prognostic value for all-cause mortality and a milder course. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Inappropriate antibiotic use in the COVID-19 era: Factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID.
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Calderón-Parra J, Muiño-Miguez A, Bendala-Estrada AD, Ramos-Martínez A, Muñez-Rubio E, Fernández Carracedo E, Tejada Montes J, Rubio-Rivas M, Arnalich-Fernandez F, Beato Pérez JL, García Bruñén JM, Del Corral Beamonte E, Pesqueira Fontan PM, Carmona MDM, Fernández-Madera Martínez R, González García A, Salazar Mosteiro C, Tuñón de Almeida C, González Moraleja J, Deodati F, Martín Escalante MD, Asensio Tomás ML, Gómez Huelgas R, Casas Rojo JM, and Millán Núñez-Cortés J
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- Acute Kidney Injury etiology, Aged, Anti-Bacterial Agents administration & dosage, C-Reactive Protein analysis, COVID-19 complications, COVID-19 virology, Comorbidity, Cough etiology, Dyspnea etiology, Female, Fever etiology, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Registries, Retrospective Studies, Risk Factors, SARS-CoV-2 isolation & purification, Anti-Bacterial Agents adverse effects, COVID-19 pathology, Inappropriate Prescribing adverse effects
- Abstract
Background: Most patients with COVID-19 receive antibiotics despite the fact that bacterial co-infections are rare. This can lead to increased complications, including antibacterial resistance. We aim to analyze risk factors for inappropriate antibiotic prescription in these patients and describe possible complications arising from their use., Methods: The SEMI-COVID-19 Registry is a multicenter, retrospective patient cohort. Patients with antibiotic were divided into two groups according to appropriate or inappropriate prescription, depending on whether the patient fulfill any criteria for its use. Comparison was made by means of multilevel logistic regression analysis. Possible complications of antibiotic use were also identified., Results: Out of 13,932 patients, 3047 (21.6%) were prescribed no antibiotics, 6116 (43.9%) were appropriately prescribed antibiotics, and 4769 (34.2%) were inappropriately prescribed antibiotics. The following were independent factors of inappropriate prescription: February-March 2020 admission (OR 1.54, 95%CI 1.18-2.00), age (OR 0.98, 95%CI 0.97-0.99), absence of comorbidity (OR 1.43, 95%CI 1.05-1.94), dry cough (OR 2.51, 95%CI 1.94-3.26), fever (OR 1.33, 95%CI 1.13-1.56), dyspnea (OR 1.31, 95%CI 1.04-1.69), flu-like symptoms (OR 2.70, 95%CI 1.75-4.17), and elevated C-reactive protein levels (OR 1.01 for each mg/L increase, 95% CI 1.00-1.01). Adverse drug reactions were more frequent in patients who received ANTIBIOTIC (4.9% vs 2.7%, p < .001)., Conclusion: The inappropriate use of antibiotics was very frequent in COVID-19 patients and entailed an increased risk of adverse reactions. It is crucial to define criteria for their use in these patients. Knowledge of the factors associated with inappropriate prescribing can be helpful., Competing Interests: The authors have declared that no competing interests exist.
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- 2021
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13. Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain.
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Rodilla E, López-Carmona MD, Cortes X, Cobos-Palacios L, Canales S, Sáez MC, Campos Escudero S, Rubio-Rivas M, Díez Manglano J, Freire Castro SJ, Vázquez Piqueras N, Mateo Sanchis E, Pesqueira Fontan PM, Magallanes Gamboa JO, González García A, Madrid Romero V, Tamargo Chamorro L, González Moraleja J, Villanueva Martínez J, González Noya A, Suárez-Lombraña A, Gracia Gutiérrez A, López Reboiro ML, Ramos Rincón JM, and Gómez Huelgas R
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- Age Factors, Aged, Aged, 80 and over, Blood Pressure, COVID-19 mortality, Cardiovascular Diseases epidemiology, Cause of Death, Comorbidity, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Obesity epidemiology, Odds Ratio, Prognosis, Pulmonary Disease, Chronic Obstructive epidemiology, Registries, Retrospective Studies, Spain epidemiology, COVID-19 epidemiology, Hospital Mortality, Hypertension epidemiology, Pandemics, SARS-CoV-2, Vascular Stiffness
- Abstract
Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P <0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P =0.0001; ORadj: 1.48, P =0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P =0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P =0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P =0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization.
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- 2021
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