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Two new mixed-ligand-based compounds, namely [Co(1,3-pde)(4-bpmh)]n (1) and [Zn3(3,3���-bpdc)3(4-bpmh)1.5]n (2) (1,3-H2pde = 1,3-phenylenediacetic acid, 3,3���-H2bpdc = biphenyl-3,3'-dicarboxylic acid, 4-bpmh = N,N-bis-pyridin-4-ylmethylene-hydrazine) have been prepared under hydrothermal conditions. The obtained compounds were determined by singe crystalX-ray diffraction analyses, elemental analyses, powder X-ray diffraction analyses and thermogravimetric analyses. Moreover, the photocatalytic activity of 1 and luminescent property of 2 have also been investigated. This presented research estimate their treatment activity of the polycystic ovary syndrome, also the mechanism was measured as well. Firstly, a relative expression of the estrogen receptor on the ovarian epithelial cells was determined with real time RT-PCR. In addition, the amount of progesterone of the plasma was measured with ELISA detection kit after indicated treatment.

Optic-electric responsive materials have attracted much attention for their applications in temperature-sensing, actuators, and memory switches. However, it is a challenge to integrate various functions to form multifunctional responsive materials. As molecule-based hybrid materials usually consist of organic and inorganic components, the introduction of multiple functions can be achieved through structural construction. Thus far, even though full-temperature cover is required for device applications, full-temperature covered multi-switchable hybrid materials have rarely been successfully synthesized. Herein, the dynamic [(CH3)3NOH]+ cation and luminous center Mn(II) were introduced to form a hybrid material [(CH3)3NOH][MnCl3], showing multiple temperature-responsive behaviors. Upon temperature change, it exhibits multi-state dielectric switching response and intensity or peak shift response of luminous in full-temperature range (low, room, and high temperatures). These responsive behaviors are triggered by the motion or reorientation of [(CH3)3NOH]+ cations and inorganic framework. Overall, the switchable photoelectric material has potential applications in multiple encrypted storage and sensor devices.

Molecular ferroelectrics are attracting tremendous interest because of their low cost, mechanical flexibility, easy processing, low weight, and low acoustical impedance. Moreover, their combination of ferroelectric and optical properties has led to investigations of their many potential applications, such as low-energy electron excitation and field emission displays. However, luminescent molecular ferroelectrics have rarely been reported, except for several AMnX3-type or lanthanide ion-based luminescent ferroelectrics. Here, we report the first above-room-temperature phosphonium-based molecular ferroelectric perovskite, [(CH3)4P]CdCl3 (1), with a high Curie temperature (Tc = 348 K) and moderate remanent polarization (Pr = 0.43 μC/cm2). Using piezoresponse force microscopy (PFM), the typical stripe-like domains of ferroelectrics can be observed. Moreover, 1 exhibits orange luminescence under UV excitation after doping with Sb3+, which represents a first step toward realizing luminescence-enhanced molecular ferroelectrics with various wavelengths. These results will inspire the further exploration of phosphonium-based ferroelectrics and pave the way toward practical applications in ferroelectric luminescence and/or multifunctional devices. A molecule that can be manipulated with electric fields while simultaneously acting as a light-emitting phosphor could find use in next-generation photovoltaics. Ferroelectric materials are positively charged on one end and negatively on the other. Recent work suggests that the spontaneous dipoles formed by these charges can help engineer high outputs in solar cells. Lin Zhou from Southeast University in Nanjing, China, and colleagues have developed a ferroelectric with improved characteristics for device manufacturing. The team combined organo-phosphorus cations with trichlorocadmate anions to produce an organic–inorganic composite that can be synthesized at room temperature, instead of the energetically intense conditions needed for conventional all-inorganic ferroelectrics. Adding small portions of antimony ions to the molecule generated strong luminescent emissions that may be used to concentrate and direct solar radiation. A phosphonium-based perovskite, [(CH3)4P]CdCl3, is designed and synthesized, which shows ferroelectric characteristics below 348 K as revealed by the observation of typical stripe-like domains and hysteresis loops. By doping with Sb3+, this material exhibits orange luminescence under UV excitation. This work will open new avenues in designing multifunctional luminescent molecular ferroelectrics.

Peroxisome proliferator-activated receptor γ (PPAR-γ) has a protective role in several neurological diseases. The present study investigated the effect of the PPAR-γ agonist, pioglitazone, on the mammalian target of rapamycin (mTOR) signaling pathway in a rat model of pentylenetetrazol (PTZ)-induced status epilepticus (SE). The investigation proceeded in two stages. First, the course of activation of the mTOR signaling pathway in PTZ-induced SE was examined to determine the time-point of peak activity, as reflected by phopshorylated (p)-mTOR/mTOR and p-S6/S6 ratios. Subsequently, pioglitazone was administrated intragastrically to investigate its effect on the mTOR signaling pathway, through western blot and immunochemical analyses. The levels of the interleukin (IL)-1β and IL-6 inflammatory cytokines were detected using ELISA, and neuronal loss was observed via Nissl staining. In the first stage of experimentation, the mTOR signaling pathway was activated, and the p-mTOR/mTOR and p-S6/S6 ratios peaked on the third day. Compared with the vehicle treated-SE group, pretreatment with pioglitazone was associated with the loss of fewer neurons, lower levels of IL-1β and IL-6, and inhibition of the activation of the mTOR signaling pathway. Therefore, the mTOR signaling pathway was activated in the PTZ-induced SE rat model, and the PPAR-γ agonist, pioglitazone, had a neuroprotective effect, by inhibiting activation of the mTOR pathway and preventing the increase in the levels of IL-1β and IL-6.

The reaction of dimethylamine, 18-crown-6, and perchloric acid in methanol yields the title compound, C2H8N+·ClO4−·C12H24O6·H2O. The dimethylammonium cation and the water molecule interact with the 18-crown-6 unit: N—H...O hydrogen bonds are formed between the ammonium NH2+ group and four O atoms of the crown ether, while the water molecule on the other side of 18-crown-6 ring forms O—H...O hydrogen bonds with two other O atoms of the crown ether. All conventional donors and acceptors in the cations are thus engaged in hydrogen bonding. The ClO4− anion is disordered over two sites, and occupancies for the disordered O atoms were fixed at 0.5. In the crystal, the cations and anions are arranged in alternating layers.

The crystal structure of the title compound, (C6H7FN)2[CuCl4], consists of parallel two-dimensional perovskite-type layers of corner-sharing CuCl6 octahedra. These are bonded together via N—H...Cl hydrogen bonds from the 4-fluoroanilinium chains, which are almost perpendicular to the layers. The CuCl4 dianions have two short Cu—Cl bonds [2.2657 (15) and 2.2884 (13) Å] and two longer bonds [2.8868 (15) Å], giving highly Jahn–Teller-distorted CuCl6 octahedra. The Cu atoms are situated on crystallographic centers of inversion.

The reaction of 1-bromo-methyl-1,4-diazo-niabicyclo-[2.2.2]octane bromide, zinc chloride and hydro-chloric acid in water yields the title compound, (C(7)H(15)BrN(2))[ZnCl(4)]. In the crystal, the components are linked by N-H⋯Cl hydrogen bonds. The Zn(II) atom has an approximately tetra-hedral coordination geometry.

The reaction of dimethylamine hydrochloride, 18-crown-6 and ferric chloride in ethanol yields the title compound, (C2H8N)[FeCl4]·C12H24O6, which exhibits an unusual supramolecular structure. The protonated dimethylamine contains one NH2+ group, resulting in a 1:1 supramolecular rotator–stator structure (CH3—NH2+—CH3)(18-crown-6), through N—H...O hydrogen-bonding interactions between the ammonium group of the cation and the O atoms of the crown ether. In the crystal, all three components lie on a common crystallographic mirror plane normal to [010].

In the title hydrated salt, 2,4,6-triamino-1,3,5-triazin-1-ium perchlorate monohydrate, C3H7N6+·ClO4−·H2O, the constituents are linked via hydrogen bonds of the O—H...O, N—H...O, N—H...N and N—H...Cl types. All the H atoms of the melaminium cation are involved in the hydrogen bonds. The melaminium residues are interconnected by four N—H...N hydrogen bonds, forming chains parallel to (111). The ribbons are interconnected by other hydrogen bonds as well as by π–π interactions [centroid–centroid distance = 3.8097 (7) Å].

In the title melaminium salt, 2,4,6-triamino-1,3,5-triazin-1-ium iodide monohydrate, C3H7N6+·I−·H2O, the components are linked via N—H...O, N—H...N, O—H...I and N—H...I hydrogen bonds. All of the H atoms of the melaminium cation are involved in hydrogen bonds. The melaminium cations are interconnected by four N—H...N hydrogen bonds, forming ribbons along [111]. The water molecules connected by N—H...O hydrogen bonds also form part of these ribbons. The ribbons are interconnected by other hydrogen bonds (O—H...I and N—H...I), as well as by π–π interactions [centroid–centroid distance = 3.6597 (17) Å].

There are two independent molecules in the asymmetric unit of the title compound, C21H21NO2, which was synthesized by the one-pot reaction of 2-naphthol, morpholine and benzaldehyde. The dihedral angles between the naphthalene ring systems and the benzene rings are 84.03 (7) and 75.76 (8)° in the two molecules and an intramolecular O—H...N hydrogen bond occurs in each independent molecule.