30 results on '"Pinto AG"'
Search Results
2. Perceval Less Invasive Aortic Replacement Register: multicentric Spanish experience with the Perceval S bioprosthesis in moderate-high-risk aortic surgery
- Author
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Garcia, EB, Rosell, MLC, Cid, FE, Dominguez, ES, Barrera, RR, Sbraga, F, Puente, JG, Diez, ER, Caballero, GPC, Munguira, JB, Copa, GR, Pajuelo, MT, Fiz, SS, Minano, JAB, Martin, IG, Castillo, JC, Lopez, SC, Pinto, AG, and Baliarda, XR
- Subjects
Transcatheter aortic valve implantation ,Sutureless ,Moderate-high risk ,Aortic valve stenosis - Abstract
OBJECTIVES: The development of new percutaneous and surgical techniques has reduced the risk associated with aortic valve replacement procedures. We present the results of a Spanish register after initiating a programme for sutureless prostheses in moderate-high-risk patients. METHODS: This prospective multicentre study was carried out from November 2013 to November 2016. Data were obtained from 448 patients in whom a Perceval S prosthesis was implanted. RESULTS: The mean age was 79.24 (standard deviation [SD] 4.1) years, and 61.2% were women. The estimated EuroSCORE I log risk was 11.15% (SD 7.6), with an observed mortality of 4.4% (20 patients). Isolated aortic valve replacement was performed on 69.26% of patients, with 64% involving ministernotomy. The incidence of neurological events was 2%, with 2 permanent cerebrovascular accidents, and 41 (9.2%) patients were implanted with a permanent endocavitary pacemaker. At discharge, 12 (2.6%) patients presented minimal periprosthetic leakage, and 4 (0.89%) patients had moderate leakage. There were 3 reinterventions during follow-up (2 endocarditis and 1 dysfunction due to periprosthetic leak progression). The mean gradient at discharge, 6 months and 1 year was 12.94 (SD 5.3) mmHg, 12.19 (SD 4.7) mmHg and 11.77 (SD 4.7) mmHg, respectively; 59.4% of the patients were octogenarians, with a survival rate of 98% at both 6 months and 1 year at discharge. There was neither valve migration nor early structural degeneration. The mean follow-up was 12 +/- 3 months. The 6-month and 1-year mortality was 1.4% and 2.1%, respectively. CONCLUSIONS: This is a prospective multicentric study on the largest cohort of patients with sutureless valves conducted in Spain to date. It is a reproducible procedure that has enabled surgery on patients with a moderate-high risk with low morbidity and mortality, providing good haemodynamic results.
- Published
- 2018
3. Resumption Of Postpartum Fecundability In Rural Guatemala: A Multistate Approach
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Pinto Aguirre, Guido
- Subjects
Post-partum fecundity ,breast feeding ,maternal and child health ,Economic theory. Demography ,HB1-3840 - Abstract
The purpose of this paper is to investigate and re-estimate the effects of breastfeeding patterns, women's nutritional and health status, and energy expenditure on the timing of resumption of postpartum fecundability (i.e. resumption of postpartum menses) using all the relevant information in the Instituto de Nutrición de Centroamérica y Panamá longitudinal study and a more adequate estimation procedure (hazard models). The data used in this study come from a Longitudinal Study carried out in Guatemala between 1967 and 1979. In this article we use a multi-state hazard model that recognizes different pathways and states in the process of returning to the postpartum fecundability. The model relies on the existence of five states (fully breastfeeding, partial breastfeeding, weaning, infant mortality and menses). It also includes explicitly maternal nutrition and women's energy expenditure as strategic elements of the model. The study shows that the estimated effects of breastfeeding patterns, maternal nutrition and women's work patterns (energy expenditure) on resumption of fecundability in rural Guatemala are strong and significant. The contribution of this paper is to show that application of hazard models with multiple states provides estimates that are consistent with hypotheses relating lactation patterns, maternal nutritional status and maternal external stressors to processes that accelerate (decelerate) resumption of normal menstrual cycles.
- Published
- 2008
4. The Relationship between Domestic Violence and Reproductive Health and Family Planning Services in Bolivia, 2003
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Pinto Aguirre, Guido, Kincaid, Mary, and Murillo Gutiérrez, Beatriz
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Domestic Violence ,Family Planning Services ,Reproductive Health ,Economic theory. Demography ,HB1-3840 - Abstract
The main purpose of this paper is to understand the relationship existing between Gender-Based Violence (GVB) and the Use of Reproductive Health and Family Planning services. To carry out this task, we use multivariate logit regression models to explore the direction and strength of the relationship, using a population-based sample for Bolivian women during 2003-2004. Results show a strong, negative and significant relationship between GVB and use of RH/FP services at the population-level, after adjusting for respondent’s and partner’s individual and household characteristics. That is, GBV is strongly and significantly associated with the use of RH/FP services, in a way that women experiencing domestic violence are less likely to use those services.
- Published
- 2010
5. Child Mortality and Reproductive Patterns in Bolivia, 1993-1998
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Pinto Aguirre, Guido
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Infant mortality ,Reproductive patterns ,Economic theory. Demography ,HB1-3840 - Abstract
The objective of the present study is to examine the effects of several reproductive and demographic factors on child survival in Bolivia, one of the most impoverished nations in all of Latin America. We model the joint effects of maternal age, parity, pace of childbearing, duration of breastfeeding, and use of modern contraception on child mortality. Data for this research come from “Demographic and Health Survey” (DHS) carried out during 1998. The results obtained in this paper support the evidence found in other studies: breastfeeding and the pace of childbearing are the most important reproductive patterns affecting child mortality risks, and their strong, consistent effects tend to persist even after the introduction of various socioeconomic variables as controls: short preceding birth intervals and short durations of breastfeeding increase the risk of death during the first two years of life.
- Published
- 2007
6. Breastfeeding and Postpartum Amenorrhea in Rural Guatemala
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Pinto Aguirre, Guido and Jones, Robert E.
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Amenorrea post-partum ,Breast feeding ,Economic theory. Demography ,HB1-3840 - Abstract
The association between breastfeeding patterns and resumption of postpartum menstruation was examined in rural Guatemalan women from the INCAP longitudinal study (1969-1977). It was distinguished among women who experienced infant mortality before menses resumed, women who weaned before menses resumed, and women who had return of menses while still breastfeeding. Weaning and infant mortality before menses resumes are significant risk factors for resumption of postpartum menstruation. Among those women whose menses resumed while still nursing or who remained amenorrheic and nursing at lose to follow-up or the end of the study, low number of nursing bouts per 24-hr day and the early introduction of supplements to the child were significant risk factors for the return of postpartum menstruation.
- Published
- 2005
7. The David Versus the Bentall Procedure for Acute Type A Aortic Dissection.
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Biancari F, Mastroiacovo G, Rinaldi M, Ferrante L, Mäkikallio T, Juvonen T, Mariscalco G, El-Dean Z, Pettinari M, Rodriguez Lega J, Pinto AG, Perrotti A, Onorati F, Wisniewski K, Demal T, Kacer P, Rocek J, Di Perna D, Vendramin I, Piani D, Quintana E, Pruna-Guillen R, Buech J, Radner C, Kuduvalli M, Harky A, Fiore A, Dell'Aquila AM, Gatti G, Conradi L, Field M, Galotta A, Fileccia D, Nanci G, and Peterss S
- Abstract
Background : Type A aortic dissection (TAAD) is a life-threatening condition which requires prompt diagnosis and surgical treatment. When TAAD involves the aortic root, aortic valve-sparing or Bentall procedures are the main surgical treatment options. Method: The subjects of this analysis were 3735 patients included in the European Registry of Type A Aortic Dissection (ERTAAD). Propensity score matching was performed by estimating a propensity score from being treated with the Bentall or the David procedure using multilevel mixed-effects logistics, considering the cluster effect of the participating hospitals. Results: A Bentall procedure was performed in 862 patients, while a David operation was performed in 139 patients. The proportion of aortic root replacement, as well as the different techniques of aortic root replacement, varied significantly between the participating hospitals ( p < 0.001). After propensity score matching, we obtained two groups of 115 patients each, and no statistical differences were reported in terms of postoperative outcomes, except for the rate of dialysis, which was higher in the patients requiring a Bentall procedure (17.4% vs. 7.0%, p -value 0.016). In the unmatched cohorts, the David procedure was associated with a lower 10-year mortality rate compared to the Bentall procedure (30.1% vs. 45.6%, p -value 0.004), but no difference was observed after matching (30.0% vs. 43.9%, p -value 0.082). After 10 years, no differences were observed in terms of proximal aortic reoperation (3.9% vs. 4.1%, p -value 0.954), even after propensity score matching (2.8% vs. 1.8%, p -value 0.994). Conclusions: The David and Bentall procedures are durable treatment methods for TAAD. When feasible, it is advisable that the David procedure is performed for acute TAAD by surgeons with experience with this demanding surgical technique.
- Published
- 2024
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8. Aortic arch surgery for DeBakey type 1 aortic dissection in patients aged 60 years or younger.
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Biancari F, Lega JR, Mariscalco G, Peterss S, Buech J, Fiore A, Perrotti A, Rukosujew A, Pinto AG, Demal T, Wisniewski K, Pol M, Gatti G, Vendramin I, Rinaldi M, Pruna-Guillen R, Di Perna D, El-Dean Z, Sherzad H, Nappi F, Field M, Pettinari M, Jormalainen M, Dell'Aquila AM, Onorati F, Quintana E, Juvonen T, and Mäkikallio T
- Subjects
- Humans, Male, Female, Middle Aged, Aortic Aneurysm, Thoracic surgery, Aortic Aneurysm, Thoracic mortality, Adult, Retrospective Studies, Treatment Outcome, Europe epidemiology, Propensity Score, Aortic Dissection surgery, Aortic Dissection mortality, Aorta, Thoracic surgery, Reoperation statistics & numerical data, Postoperative Complications epidemiology, Blood Vessel Prosthesis Implantation methods, Blood Vessel Prosthesis Implantation adverse effects, Blood Vessel Prosthesis Implantation mortality
- Abstract
Background: Extended aortic repair is considered a key issue for the long-term durability of surgery for DeBakey type 1 aortic dissection. The risk of aortic degeneration may be higher in young patients due to their long life expectancy. The early outcome and durability of aortic surgery in these patients were investigated in the present study., Methods: The subjects of the present analysis were patients under 60 years old who underwent surgical repair for acute DeBakey type 1 aortic dissection at 18 cardiac surgery centres across Europe between 2005 and 2021. Patients underwent ascending aortic repair or total aortic arch repair using the conventional technique or the frozen elephant trunk technique. The primary outcome was 5-year cumulative incidence of reoperation on the distal aorta., Results: Overall, 915 patients underwent surgical ascending aortic repair and 284 patients underwent surgical total aortic arch repair. The frozen elephant trunk procedure was performed in 128 patients. Among 245 propensity score-matched pairs, total aortic arch repair did not decrease the rate of distal aortic reoperation compared to ascending aortic repair (5-year cumulative incidence, 6.7% versus 6.7%, subdistributional hazard ratio 1.127, 95% c.i. 0.523 to 2.427). Total aortic arch repair increased the incidence of postoperative stroke/global brain ischaemia (25.7% versus 18.4%, P = 0.050) and dialysis (19.6% versus 12.7%, P = 0.003). Five-year mortality was comparable after ascending aortic repair and total aortic arch repair (22.8% versus 27.3%, P = 0.172)., Conclusions: In patients under 60 years old with DeBakey type 1 aortic dissection, total aortic arch replacement compared with ascending aortic repair did not reduce the incidence of distal aortic operations at 5 years. When feasible, ascending aortic repair for DeBakey type 1 aortic dissection is associated with satisfactory early and mid-term outcomes., Trial Registration: ClinicalTrials.gov Identifier: NCT04831073., (© The Author(s) 2024. Published by Oxford University Press on behalf of BJS Foundation Ltd.)
- Published
- 2024
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9. Baseline risk factors of in-hospital mortality after surgery for acute type A aortic dissection: an ERTAAD study.
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Biancari F, Demal T, Nappi F, Onorati F, Francica A, Peterss S, Buech J, Fiore A, Folliguet T, Perrotti A, Hervé A, Conradi L, Rukosujew A, Pinto AG, Lega JR, Pol M, Rocek J, Kacer P, Wisniewski K, Mazzaro E, Vendramin I, Piani D, Ferrante L, Rinaldi M, Quintana E, Pruna-Guillen R, Gerelli S, Di Perna D, Acharya M, Mariscalco G, Field M, Kuduvalli M, Pettinari M, Rosato S, D'Errigo P, Jormalainen M, Mustonen C, Mäkikallio T, Dell'Aquila AM, Juvonen T, and Gatti G
- Abstract
Background: Surgery for type A aortic dissection (TAAD) is associated with high risk of mortality. Current risk scoring methods have a limited predictive accuracy., Methods: Subjects were patients who underwent surgery for acute TAAD at 18 European centers of cardiac surgery from the European Registry of Type A Aortic Dissection (ERTAAD)., Results: Out of 3,902 patients included in the ERTAAD, 2,477 fulfilled the inclusion criteria. In the validation dataset (2,229 patients), the rate of in-hospital mortality was 18.4%. The rate of composite outcome (in-hospital death, stroke/global ischemia, dialysis, and/or acute heart failure) was 41.2%, and 10-year mortality rate was 47.0%. Logistic regression identified the following patient-related variables associated with an increased risk of in-hospital mortality [area under the curve (AUC), 0.755, 95% confidence interval (CI), 0.729-0.780; Brier score 0.128]: age; estimated glomerular filtration rate; arterial lactate; iatrogenic dissection; left ventricular ejection fraction ≤50%; invasive mechanical ventilation; cardiopulmonary resuscitation immediately before surgery; and cerebral, mesenteric, and peripheral malperfusion. The estimated risk score was associated with an increased risk of composite outcome (AUC, 0.689, 95% CI, 0.667-0.711) and of late mortality [hazard ratio (HR), 1.035, 95% CI, 1.031-1.038; Harrell's C 0.702; Somer's D 0.403]. In the validation dataset (248 patients), the in-hospital mortality rate was 16.1%, the composite outcome rate was 41.5%, and the 10-year mortality rate was 49.1%. The estimated risk score was predictive of in-hospital mortality (AUC, 0.703, 95% CI, 0.613-0.793; Brier score 0.121; slope 0.905) and of composite outcome (AUC, 0.682, 95% CI, 0.614-0.749). The estimated risk score was predictive of late mortality (HR, 1.035, 95% CI, 1.031-1.038; Harrell's C 0.702; Somer's D 0.403), also when hospital deaths were excluded from the analysis (HR, 1.024, 95% CI, 1.018-1.031; Harrell's C 0.630; Somer's D 0.261)., Conclusions: The present analysis identified several baseline clinical risk factors, along with preoperative estimated glomerular filtration rate and arterial lactate, which are predictive of in-hospital mortality and major postoperative adverse events after surgical repair of acute TAAD. These risk factors may be valuable components for risk adjustment in the evaluation of surgical and anesthesiological strategies aiming to improve the results of surgery for TAAD., Clinical Trial Registration: https://clinicaltrials.gov, identifier NCT04831073., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (© 2024 Biancari, Demal, Nappi, Onorati, Francica, Peterss, Buech, Fiore, Folliguet, Perrotti, Hervé, Conradi, Rukosujew, Pinto, Lega, Pol, Rocek, Kacer, Wisniewski, Mazzaro, Vendramin, Piani, Ferrante, Rinaldi, Quintana, Pruna-Guillen, Gerelli, Di Perna, Acharya, Mariscalco, Field, Kuduvalli, Pettinari, Rosato, D'Errigo, Jormalainen, Mustonen, Mäkikallio, Dell'aquila, Juvonen and Gatti.)
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- 2024
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10. Infectious complications following major heart surgery from the day of the surgery to hospital discharge.
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Pérez-Granda MJ, Barrio JM, Cuerpo G, Valerio M, Muñoz P, Hortal J, Pinto AG, and Bouza E
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- Humans, Aged, Patient Discharge, Retrospective Studies, Heart, Hospitals, Cardiac Surgical Procedures adverse effects, Cross Infection epidemiology, Cross Infection etiology
- Abstract
Background: At some point in their lives, many people will require major heart surgery (MHS). Patients are generally older adults with various risk factors for infection. However, the incidence of infection after MHS is poorly known, as reported infection data are frequently biased due to different factors like the surgical procedure, postoperative timing, and infectious syndromes or etiologic agents, among others. In addition, most patient data are retrospectively obtained., Purpose and Methods: Data were prospectively collected regarding the incidence of all nosocomial infections produced from the time of surgery to hospital discharge in a cohort of 800 adults consecutively undergoing a MHS procedure., Results: During postoperative hospitalization, 124 of the 800 participants developed one or more infections (15.5%): during their ICU stay in 68 patients (54.8%), during their stay on the general ward post ICU in 50 (40.3%), and during their stay in both wards in 6 (4.8%). The most common infections were pneumonia (related or not to mechanical ventilation), surgical site and bloodstream. As etiological agents, 193 pathogens were isolated: mostly Gram-negative bacilli (54.4%), followed by Gram-positive bacteria (30%), viruses (4.6%) and fungi (1.5%). In our cohort, all-cause mortality was recorded in 33 participants (4.1%) and 9 infection-related deaths (1.1%) were produced. Among subjects who developed infections, overall mortality was 13.7% and in those who did not, this was only 2.3%., Conclusion: Infection following MHS remains frequent and severe. Our data suggest that hospital-acquired infection studies should consider episodes of infection in all populations during their entire hospital stay and not only those related to specific clinical syndromes or acquired while the patient is in intensive care., (© 2024. The Author(s).)
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- 2024
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11. Chemiluminescence of a Firefly Luciferin Analogue Reveals that Formation of the Key Intermediate Responsible for Excited State Generation Occurs on a Fully Concerted Step.
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Melo DU, Bergonzini de Lima H, Reis RA, Boaro A, Gonçalves Costa Pinto AG, Monteiro Leite Ciscato LF, Homem-de-Mello P, and Bartoloni FH
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The chemiluminescence (CL) reaction of eight different 2-(4-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylate esters with an organic superbase and oxygen was investigated through a kinetic and computational study. These esters are all analogues to the luciferin substrate involved in efficient firefly bioluminescence. The kinetic data obtained from CL emission and light absorption assays were used in the context of linear free energy relationships (LFER); we obtained the Hammett reaction constant ρ = +1.62 ± 0.09 and the Brønsted constant β
lg = -0.39 ± 0.04. These observations from LFER, together with activation parameters obtained from Arrhenius plots, suggest that the formation of the high-energy intermediate (HEI) 1,2-dioxetanone occurs via a concerted mechanism during the rate-determining step of the reaction. Calculations performed using density functional theory support a late transition state for HEI formation within the reaction mechanism pathway, which was described considering geometric parameters, Wiberg bond indices from natural bond order analysis, and the atomic charges derived from the electrostatic potential.- Published
- 2024
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12. Preoperative arterial lactate and outcome after surgery for type A aortic dissection: The ERTAAD multicenter study.
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Biancari F, Nappi F, Gatti G, Perrotti A, Hervé A, Rosato S, D'Errigo P, Pettinari M, Peterss S, Buech J, Juvonen T, Jormalainen M, Mustonen C, Demal T, Conradi L, Pol M, Kacer P, Dell'Aquila AM, Wisniewski K, Vendramin I, Piani D, Ferrante L, Mäkikallio T, Quintana E, Pruna-Guillen R, Fiore A, Folliguet T, Mariscalco G, Acharya M, Field M, Kuduvalli M, Onorati F, Rossetti C, Gerelli S, Di Perna D, Mazzaro E, Pinto AG, Lega JR, and Rinaldi M
- Abstract
Background: Acute type A aortic dissection (TAAD) is associated with significant mortality and morbidity. In this study we evaluated the prognostic significance of preoperative arterial lactate concentration on the outcome after surgery for TAAD., Methods: The ERTAAD registry included consecutive patients who underwent surgery for acute type A aortic dissection (TAAD) at 18 European centers of cardiac surgery., Results: Data on arterial lactate concentration immediately before surgery were available in 2798 (71.7 %) patients. Preoperative concentration of arterial lactate was an independent predictor of in-hospital mortality (mean, 3.5 ± 3.2 vs 2.1 ± 1.8 mmol/L, adjusted OR 1.181, 95%CI 1.129-1.235). The best cutoff value preoperative arterial lactate concentration was 1.8 mmol/L (in-hospital mortality, 12.0 %, vs. 26.6 %, p < 0.0001). The rates of in-hospital mortality increased along increasing quintiles of arterial lactate and it was 12.1 % in the lowest quintile and 33.6 % in the highest quintile (p < 0.0001). The difference between multivariable models with and without preoperative arterial lactate was statistically significant (p = 0.0002). The NRI was 0.296 (95%CI 0.200-0.391) (p < 0.0001) with -17 % of events correctly reclassified (p = 0.0002) and 46 % of non-events correctly reclassified (p < 0.0001). The IDI was 0.025 (95%CI 0.016-0.034) (p < 0.0001). Six studies from a systematic review plus the present one provided data for a pooled analysis which showed that the mean difference of preoperative arterial lactate between 30-day/in-hospital deaths and survivors was 1.85 mmol/L (95%CI 1.22-2.47, p < 0.0001, I
2 64 %)., Conclusions: Hyperlactatemia significantly increased the risk of mortality after surgery for acute TAAD and should be considered in the clinical assessment of these critically ill patients., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Fausto Biancari reports financial support was provided by 10.13039/501100005633Finnish Foundation for Cardiovascular Research. Fausto Biancari reports financial support was provided by Sigrid Jusélius Foundation., (© 2023 The Authors.)- Published
- 2023
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13. Studying the Degradation of Three Polymers under Different Chlorine Concentrations and Exposure Times.
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Barbosa MLS, Costa RDFS, Silva FJG, Sousa SR, Pinto AG, and Ferreira BO
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Due to chlorine's ability to kill bacteria and fungi through a chemical reaction, chlorine solutions are commonly used to clean and disinfect numerous public facilities, although these actions are also dependent to the equipment present in those facilities. Accordingly, the interest in studying its effect when in contact with different materials is obvious. This study was carried out through accelerated degradation tests and various analysis methods (optical microscope, scanning electron microscope, and tensile tests). The objective was to observe the wear presented by three polymeric materials, polyvinyl chloride (PVC), high-density polyethylene (HDPE), and polypropylene (PP), when exposed to chlorine's action in swimming pools and drinking water treatment plants. The resulting effect depends on the chlorine content and the type of contact between the chemical agent and the material. The aim was to select the material less likely to be affected by chlorine through tests and analyses, allowing a longer component life. The use of certain more resistant polymeric materials can drastically reduce maintenance, reducing fundamental factors such as costs, the downtime of municipal facilities, and also the risk to public health. It was concluded that PVC has the most stable behaviour overall when in contact with chlorine solutions.
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- 2023
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14. The Impact of the Deterioration on Wood by Chlorine: An Experimental Study.
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Costa RDFS, Barbosa MLS, Silva FJG, Sousa SR, Pinto AG, Sousa VFC, and Ferreira BO
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The use of disinfection and cleaning chemicals in several municipal facilities, such as swimming pools and drinking water treatment plants, causes the degradation of various types of wood, which leads to failures in equipment and the corresponding need for maintenance. This degradation creates added costs for municipalities, as well as the closure of certain facilities due to curative or preventive maintenance and, in many cases, public health issues, due to the water being contaminated with deteriorating products. Through a thorough study of the degradation effect on the products, more resistant materials can be found which are able to withstand these adversities and increase the lifespan of wood in regular contact with chemical agents. This is achievable by the determination of the cost-effectiveness of the substitute material to replace these components with alternative ones, with properties that better resist the deterioration effects promoted by aggressive environments. No studies have been found so far strictly focused on this matter. The objective of this study is to evaluate the degradation presented by two types of wood, beech and oak, which are exposed to the action of chlorine in municipal facilities. This degradation varies according to the chlorine content and the materials' time of contact with the chemical agent, allowing the selection of new materials which will provide an extended lifetime of the components, reducing maintenance drastically, as well as costs for the facilities and the risk to public health. The performed experimental tests have shown that the oak wood has the best results regarding chlorine degradation resistance.
- Published
- 2023
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15. Digital Forms of Commensality in the 21st Century: A Scoping Review.
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Pereira-Castro MR, Pinto AG, Caixeta TR, Monteiro RA, Bermúdez XPD, and Mendonça AVM
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- Humans, Feeding Behavior psychology, Food, Publications, Pandemics, COVID-19 epidemiology
- Abstract
The social act of eating together has been influenced and mediated by technologies in recent decades. This phenomenon has been investigated in different academic fields, but the topic is still in an incipient dimension, and there is a lack of consensus regarding terminology and definitions. The study aimed to characterize the main scientific findings regarding digital forms of commensality in the 21st century and to identify possible relationships between these practices and public health. A scoping review was conducted to identify papers published in different languages between 2001 and 2021. A total of 104 publications that combined commensality and technology in all contexts were included. Most studies were qualitative; from the Design and Technology field; used social media and video platforms or prototypes/augmented reality gadgets; and used different terms to refer to digital forms of commensality, allowing the analysis of the construction of field definitions over time. The intersections with health were observed from impacts on family/community engagement, culinary skills development, and mental health and eating habits. These practices also structured specific social interactions, such as virtual food communities and commensality, during the COVID-19 pandemic. This paper indicates the consistent growth of these practices and recommends the development of future research for theoretically and longitudinally deeper evaluations of the impacts of these new ways of eating together, especially regarding their effects on human health.
- Published
- 2022
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16. Outcome after Surgery for Iatrogenic Acute Type A Aortic Dissection.
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Biancari F, Pettinari M, Mariscalco G, Mustonen C, Nappi F, Buech J, Hagl C, Fiore A, Touma J, Dell'Aquila AM, Wisniewski K, Rukosujew A, Perrotti A, Hervé A, Demal T, Conradi L, Pol M, Kacer P, Onorati F, Rossetti C, Vendramin I, Piani D, Rinaldi M, Ferrante L, Quintana E, Pruna-Guillen R, Rodriguez Lega J, Pinto AG, Mäkikallio T, Acharya M, El-Dean Z, Field M, Harky A, Gerelli S, Di Perna D, Jormalainen M, Gatti G, Mazzaro E, Juvonen T, and Peterss S
- Abstract
(1) Background: Acute Stanford type A aortic dissection (TAAD) may complicate the outcome of cardiovascular procedures. Data on the outcome after surgery for iatrogenic acute TAAD is scarce. (2) Methods: The European Registry of Type A Aortic Dissection (ERTAAD) is a multicenter, retrospective study including patients who underwent surgery for acute TAAD at 18 hospitals from eight European countries. The primary outcomes were in-hospital mortality and 5-year mortality. Twenty-seven secondary outcomes were evaluated. (3) Results: Out of 3902 consecutive patients who underwent surgery for acute TAAD, 103 (2.6%) had iatrogenic TAAD. Cardiac surgery (37.8%) and percutaneous coronary intervention (36.9%) were the most frequent causes leading to iatrogenic TAAD, followed by diagnostic coronary angiography (13.6%), transcatheter aortic valve replacement (10.7%) and peripheral endovascular procedure (1.0%). In hospital mortality was 20.5% after cardiac surgery, 31.6% after percutaneous coronary intervention, 42.9% after diagnostic coronary angiography, 45.5% after transcatheter aortic valve replacement and nihil after peripheral endovascular procedure (p = 0.092), with similar 5-year mortality between different subgroups of iatrogenic TAAD (p = 0.710). Among 102 propensity score matched pairs, in-hospital mortality was significantly higher among patients with iatrogenic TAAD (30.4% vs. 15.7%, p = 0.013) compared to those with spontaneous TAAD. This finding was likely related to higher risk of postoperative heart failure (35.3% vs. 10.8%, p < 0.0001) among iatrogenic TAAD patients. Five-year mortality was comparable between patients with iatrogenic and spontaneous TAAD (46.2% vs. 39.4%, p = 0.163). (4) Conclusions: Iatrogenic origin of acute TAAD is quite uncommon but carries a significantly increased risk of in-hospital mortality compared to spontaneous TAAD.
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- 2022
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17. Goldilocks at the dawn of complex life: mountains might have damaged Ediacaran-Cambrian ecosystems and prompted an early Cambrian greenhouse world.
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Caxito F, Lana C, Frei R, Uhlein GJ, Sial AN, Dantas EL, Pinto AG, Campos FC, Galvão P, Warren LV, Okubo J, and Ganade CE
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- Carbon Cycle, Ecosystem, Fossils, Geologic Sediments, Geology, Oceans and Seas, Paleontology, Biological Evolution, Climate, Geological Phenomena
- Abstract
We combine U-Pb in-situ carbonate dating, elemental and isotope constraints to calibrate the synergy of integrated mountain-basin evolution in western Gondwana. We show that deposition of the Bambuí Group coincides with closure of the Goiás-Pharusian (630-600 Ma) and Adamastor (585-530 Ma) oceans. Metazoans thrived for a brief moment of balanced redox and nutrient conditions. This was followed, however, by closure of the Clymene ocean (540-500 Ma), eventually landlocking the basin. This hindered seawater renewal and led to uncontrolled nutrient input, shallowing of the redoxcline and anoxic incursions, fueling positive productivity feedbacks and preventing the development of typical Ediacaran-Cambrian ecosystems. Thus, mountains provide the conditions, such as oxygen and nutrients, but may also preclude life development if basins become too restricted, characterizing a Goldilocks or optimal level effect. During the late Neoproterozoic-Cambrian fan-like transition from Rodinia to Gondwana, the newborn marginal basins of Laurentia, Baltica and Siberia remained open to the global sea, while intracontinental basins of Gondwana became progressively landlocked. The extent to which basin restriction might have affected the global carbon cycle and climate, e.g. through the input of gases such as methane that could eventually have collaborated to an early Cambrian greenhouse world, needs to be further considered., (© 2021. The Author(s).)
- Published
- 2021
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18. Influence of smoking isolated and associated to multifactorial aspects in vocal acoustic parameters.
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Pinto AG, Crespo AN, and Mourão LF
- Subjects
- Adult, Case-Control Studies, Cohort Studies, Cross-Sectional Studies, Educational Status, Female, Humans, Male, Middle Aged, Smoking adverse effects, Speech Production Measurement, Smoking physiopathology, Speech Acoustics, Voice Quality physiology
- Abstract
Introduction: Smoking affect voice quality in a long period of time, but other factors may compromise it, such as professional using of voice, habits, alcohol dependence and GERD. The aim was associate the influence of these factors on vocal parameters., Study Design: Contemporary cohort study with cross-sectional., Materials and Methods: Eighty adults of 35 to 60 years old had participated in this study, they had been divided into two groups, smokers (GF) and control (GC). There was application of questionnaire and voices were recorded. Praat software has been used for voice assessment and Man-Whitney, chi-square and logistic regression has been used for statistical analysis., Results: The GF had a higher incidence of alcohol dependence, coughing, throat clearing and professional voice using. Respecting to the acoustic parameters: noise-to-harmonic ratio (NHR), jitter and shimmer, the GF presented higher values. Relating these data to the questionnaire, it's noticed that female gender have influence over all acoustic parameters, GERD have influence over jitter and smoking can affect fundamental frequency, jitter, shimmer and NHR., Conclusion: Smoking interferes in acoustics parameters isolated and associated with alcohol dependence, GERD, cough, throat clearing, gender and professional using of voice.
- Published
- 2014
- Full Text
- View/download PDF
19. Geriatric assessment of a giant splenic artery aneurysm accidentally diagnosed.
- Author
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Orsitto G, Fulvio F, Pinto AG, Turi V, Tria D, Venezia A, Colucci C, Castellana R, and Manca C
- Subjects
- Aged, Female, Humans, Middle Aged, Tomography, X-Ray Computed, Ultrasonography, Aneurysm diagnostic imaging, Aneurysm surgery, Geriatric Assessment, Splenic Artery diagnostic imaging, Splenic Artery surgery
- Abstract
Giant splenic artery aneurysms (GSAAs) larger than 8 cm in diameter have rarely been reported, particularly in older people. They are clinically important lesions, often asymptomatic and related to an increased risk of complications such as abrupt rupture, requiring emergency surgical treatment. Comprehensive geriatric assessment (CGA), originally developed for multidimensional clinical evaluation in several geriatric settings, was recently proposed as a fundamental preoperative aid for treatment planning of older patients undergoing elective surgery and preventing adverse post-operative outcomes. We present the first case of an asymptomatic 9-cm partially thrombosed GSAA, accidentally diagnosed during abdominal ultrasound in a 63-year-old woman from the Apulia region in Southern Italy. She successfully underwent aneurysmectomy, highlighting the usefulness of CGA in elective surgical patients.
- Published
- 2011
- Full Text
- View/download PDF
20. A proteomic focus on the alterations occurring at the human atherosclerotic coronary intima.
- Author
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de la Cuesta F, Alvarez-Llamas G, Maroto AS, Donado A, Zubiri I, Posada M, Padial LR, Pinto AG, Barderas MG, and Vivanco F
- Subjects
- Annexin A4 metabolism, Apoferritins metabolism, Case-Control Studies, Coronary Vessels metabolism, HSP27 Heat-Shock Proteins metabolism, Hemoglobins metabolism, Humans, Myosin Light Chains metabolism, Principal Component Analysis, Tandem Mass Spectrometry, Tunica Intima metabolism, Two-Dimensional Difference Gel Electrophoresis methods, Vimentin metabolism, Coronary Artery Disease metabolism, Coronary Vessels pathology, Proteome metabolism, Tunica Intima pathology
- Abstract
Coronary atherosclerosis still represents the major cause of mortality in western societies. Initiation of atherosclerosis occurs within the intima, where major histological and molecular changes are produced during pathogenesis. So far, proteomic analysis of the atherome plaque has been mainly tackled by the analysis of the entire tissue, which may be a challenging approach because of the great complexity of this sample in terms of layers and cell type composition. Based on this, we aimed to study the intimal proteome from the human atherosclerotic coronary artery. For this purpose, we analyzed the intimal layer from human atherosclerotic coronaries, which were isolated by laser microdissection, and compared with those from preatherosclerotic coronary and radial arteries, using a two-dimensional Differential-In-Gel-Electrophoresis (DIGE) approach. Results have pointed out 13 proteins to be altered (seven up-regulated and six down-regulated), which are implicated in the migrative capacity of vascular smooth muscle cells, extracellular matrix composition, coagulation, apoptosis, heat shock response, and intraplaque hemorrhage deposition. Among these, three proteins (annexin 4, myosin regulatory light 2, smooth muscle isoform, and ferritin light chain) constitute novel atherosclerotic coronary intima proteins, because they were not previously identified at this human coronary layer. For this reason, these novel proteins were validated by immunohistochemistry, together with hemoglobin and vimentin, in an independent cohort of arteries.
- Published
- 2011
- Full Text
- View/download PDF
21. Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level.
- Author
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Strasser AA, Benowitz NL, Pinto AG, Tang KZ, Hecht SS, Carmella SG, Tyndale RF, and Lerman CE
- Subjects
- Adolescent, Adult, Aged, Aryl Hydrocarbon Hydroxylases genetics, Biomarkers blood, Biomarkers urine, Cytochrome P-450 CYP2A6, Female, Genotype, Humans, Male, Middle Aged, Prognosis, Risk Assessment, Smoking genetics, Survival Rate, Young Adult, Cotinine analogs & derivatives, Cotinine blood, Nicotine pharmacokinetics, Nitrosamines urine, Pyridines urine, Smoking metabolism
- Abstract
Background: Variability in smoking behavior is partly attributable to heritable individual differences in nicotine clearance rates. This can be assessed as the ratio of the metabolites cotinine and 3'-hydroxycotinine (referred to as the nicotine metabolism ratio; NMR). We hypothesized that faster NMR would be associated with greater cigarette puff volume and higher levels of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a carcinogen biomarker., Methods: Current smokers (n = 109) smoked one of their preferred brand cigarettes through a smoking topography device and provided specimens for NMR and total NNAL assays., Results: Faster nicotine metabolizers (third and fourth quartiles versus first quartile) based on the NMR exhibited significantly greater total puff volume and total NNAL; the total puff volume by daily cigarette consumption interaction was a significant predictor of total NNAL level., Conclusion: A heritable biomarker of nicotine clearance predicts total cigarette puff volume and total NNAL., Impact: If validated, the NMR could contribute to smoking risk assessment in epidemiologic studies and potentially in clinical practice., (2011 AACR.)
- Published
- 2011
- Full Text
- View/download PDF
22. Right coronary artery injury as a complication of de Vega tricuspid annuloplasty.
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Cuerpo GP, Stuart JR, Ruiz M, and Pinto AG
- Subjects
- Aged, Cardiac Surgical Procedures methods, Female, Humans, Coronary Vessels injuries, Tricuspid Valve Insufficiency surgery
- Published
- 2009
- Full Text
- View/download PDF
23. [Report on natural infection of bats by trypanosomatid flagellates in different municipalities in the State of Rio de Janeiro].
- Author
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Barros JH, Romijn PC, Baptista C, Pinto AG, and Madeira Mde F
- Subjects
- Animals, Brazil, Urban Population, Chiroptera parasitology, Trypanosomatina isolation & purification
- Abstract
This study aimed to evaluate natural infection of bats by trypanosomatids. Using blood culturing, 86 specimens from different genera were examined, and 22 samples (25.58%) of Desmodus rotundus and Lonchorhina aurita were isolated. These results contribute towards knowledge of the occurrence of trypanosomatids in bats in the State of Rio de Janeiro.
- Published
- 2008
- Full Text
- View/download PDF
24. [Percutaneous aortic valve implantation: initial experience in Spain].
- Author
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García E, Pinto AG, Sarnago Cebada F, Pello AM, Paz M, García-Fernández MA, and Ortal J
- Subjects
- Aged, Aged, 80 and over, Aortic Valve diagnostic imaging, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Electrocardiography, Humans, Male, Spain, Treatment Outcome, Ultrasonography, Aortic Valve surgery, Heart Valve Prosthesis adverse effects, Heart Valve Prosthesis Implantation
- Abstract
Patients with symptomatic aortic stenosis have a very poor prognosis on medical treatment. In those with contraindications to surgery, percutaneous valve replacement has been proposed as an alternative. We report on physicians' initial experience in Spain with percutaneous aortic valve replacement. We analyzed inhospital and short-to-medium-term findings in four patients who underwent percutaneous implantation of a Cribier-Edwards prosthetic aortic valve. In all four cases, the Cribier-Edwards prosthetic valves were successfully implanted via the femoral artery. The procedures were guided by angiography and transesophageal echocardiography. Patients were discharged 3 to 5 days after the procedure and were still in a satisfactory clinical condition 3 months later. In summary, early experience in Spain with the percutaneous implantation of Cribier-Edwards prosthetic aortic valves indicates that it is a suitable alternative for patients for whom replacement surgery is contraindicated or would place them at a high risk.
- Published
- 2008
25. Diltiazem inhibits human intestinal cytochrome P450 3A (CYP3A) activity in vivo without altering the expression of intestinal mRNA or protein.
- Author
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Pinto AG, Horlander J, Chalasani N, Hamman M, Asghar A, Kolwankar D, and Hall SD
- Subjects
- Adult, Aged, Aryl Hydrocarbon Hydroxylases drug effects, Cytochrome P-450 CYP3A, Female, Humans, Immunoblotting methods, Male, Middle Aged, Oxidoreductases, N-Demethylating drug effects, Polymerase Chain Reaction methods, Aryl Hydrocarbon Hydroxylases antagonists & inhibitors, Calcium Channel Blockers pharmacology, Cytochrome P-450 Enzyme System metabolism, Diltiazem pharmacology, Duodenum metabolism, Oxidoreductases, N-Demethylating antagonists & inhibitors, RNA, Messenger metabolism
- Abstract
Aims: To determine the effect of diltiazem on intestinal CYP3A activity and protein and mRNA expression in vivo in healthy subjects., Methods: Intestinal biopsies were obtained from ten healthy controls and from ten healthy subjects after receiving diltiazem 120 mg bid for 7 days. Intestinal CYP3A activity, CYP3A4 protein and mRNA concentrations were quantified in both groups. Intestinal CYP3A activity was determined by incubation of small bowel homogenate with midazolam (25 microM) and NADPH for 5 min and the rate of formation of 1'-hydroxymidazolam was quantified., Results: All subjects in the treatment group had detectable diltiazem concentration in the serum. While there was no significant difference in CYP3A4 protein and mRNA expression between the control and treatment groups, the formation of 1'-hydroxymidazolam (446 pmol min(-1) mg(-1) 6 (control) vs. 170 (CI 112, 228) pmol min(-1) mg(-1) 95% confidence interval (CI 269, 623) (diltiazem group)) was significantly reduced (P < 0.05)., Conclusion: Diltiazem decreased small bowel CYP3A activity by 62% as a result of irreversible inhibition with no corresponding change in intestinal CYP3A4 mRNA or protein concentrations.
- Published
- 2005
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- View/download PDF
26. [Hematological and histopathological evaluation of BALB/c and C57BL/6 mice exposed to Cytoplasmic Repetitive Antigen and Flagellar Repetitive Antigen recombinant antigens of Trypanosoma cruzi].
- Author
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Pereira VR, de Lorena VM, Galvão-da Silva AP, Nakazawa M, da Silva ED, Ferreira AG, Montarroyos U, Coutinho Ede M, and Gomes Yde M
- Subjects
- Animals, Antigens, Protozoan administration & dosage, Chagas Disease blood, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Recombinant Proteins administration & dosage, Recombinant Proteins immunology, Antigens, Protozoan immunology, Chagas Disease immunology, Trypanosoma cruzi immunology
- Abstract
The Cytoplasmic Repetitive Antigen and Flagellar Repetitive Antigen recombinant antigens of Trypanosoma cruzi were inoculated into BALB/c and C57BL/6 mice and its effects evaluated at hematological and histopathological levels. The results showed that the histological pattern of the organs and the hematological profile of mice were not modified suggesting that these antigens are not harmful for the animal.
- Published
- 2003
- Full Text
- View/download PDF
27. Periannular extension of infective endocarditis.
- Author
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Graupner C, Vilacosta I, SanRomán J, Ronderos R, Sarriá C, Fernández C, Mújica R, Sanz O, Sanmartín JV, and Pinto AG
- Subjects
- Cohort Studies, Echocardiography, Echocardiography, Transesophageal, Female, Heart Block epidemiology, Heart Valve Prosthesis adverse effects, Heart Valves pathology, Humans, Male, Middle Aged, Myocardium pathology, Predictive Value of Tests, Prospective Studies, Prosthesis-Related Infections diagnostic imaging, Prosthesis-Related Infections microbiology, Prosthesis-Related Infections pathology, Risk Factors, Sensitivity and Specificity, Staphylococcal Infections diagnostic imaging, Staphylococcal Infections pathology, Endocarditis, Bacterial diagnostic imaging, Endocarditis, Bacterial microbiology, Endocarditis, Bacterial pathology
- Abstract
Objectives: This prospective study was designed to assess the current clinical course, risk factors, microbiologic profile and echocardiographic findings of patients with left-sided endocarditis and perivalvular complications., Background: Periannular complications worsen the prognosis of patients with endocarditis. The relation between these complications and the clinical and microbiologic data has not been clearly defined., Methods: In this clinical cohort study, 211 patients with left-sided endocarditis, according to the Duke criteria, were prospectively recruited. All patients underwent conventional and transesophageal echocardiography. The mean follow-up interval was 151 days., Results: Perivalvular complications were detected in 78 patients (37%). The incidence of periannular extension of infection in native and prosthetic valves was 29% and 55%, respectively. The presence of prosthesis (relative risk [RR] 1.88, 95% confidence interval [CI] 1.35 to 2.64) and previous endocarditis (RR 1.78, 95% CI 1.16 to 2.7) were the only pre-existing heart conditions associated with perivalvular complications. Aortic infection (RR 1.8, 95% CI 1.23 to 2.66) and the development of atrioventricular (AV) block (RR 2.55, 95% CI 1.91 to 3.41) were related with the existence of these complications. Coagulase-negative staphylococci were very common in patients with perivalvular complications (RR 1.77, 95% CI 1.21 to 2.59), and small vegetations were more frequent in these patients (RR l.45, 95% CI 0.95 to 2.22). An operation was more frequently performed in patients with perivalvular complications, but mortality was similar in patients with and without these complications., Conclusions: Aortic infection, prosthetic endocarditis, new AV block and coagulase-negative staphylococci were independent risk factors of periannular complications. The period between symptom onset and diagnosis, the incidence of pericardial effusion and persistent signs of infection were similar between patients with and without perivalvular complications. Patients with perivalvular complications did not demonstrate a difference in the presence or size of vegetations or the frequency of embolism. An operation was more frequently performed in these patients, but mortality was similar in both groups.
- Published
- 2002
- Full Text
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28. [Midterm results of coronary bypass surgery exclusively with arterial revascularization].
- Author
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Silva J, Malillos S, Villaseñor M, Marín M, Villacosta I, Martín de Dios R, and Pinto AG
- Subjects
- Arteries surgery, Female, Follow-Up Studies, Humans, Male, Middle Aged, Survival Analysis, Coronary Artery Bypass, Coronary Vessels surgery, Myocardial Revascularization
- Abstract
Introduction and Objectives: In recent years, the exclusive use of arterial grafts in coronary surgery has been the surgical option to achieve maximum survival and minimum recurrence of coronary events. The aim of this study was to analyze the surgical results and follow up of this approach., Patients and Methods: Over a period of six and a half years, 87 patients underwent coronary surgery using arterial grafts alone for revascularization. The mean age of the patients was 62 +/- 1 years with 78 men and 9 women; 22 patients (25%) were clinically unstable. The number of vessels affected per patient was 1.83 +/- 0.1, and the number of patients with one, two and three affected vessels, were 38 (44%), 26 (30%) and 23 (26%), respectively. The mean ejection fraction was 63 +/- 1.6. Emergency surgery was carried out in 13 cases (16%)., Results: A total of 1.9 +/- 0.1 grafts were implanted per patient and complete revascularization was achieved in 65 cases (75%). The left mammary artery was used in 87 cases (100%), the right mammary artery in 31 (35.6%) and the radial artery in 20 cases (23%). Hospital mortality was 1.1% (one case). During the postoperative period, 3 patients (3.4%) presented myocardial infarction, 12 (13.8%) atrial fibrillation and there were 3 cases of sternal dehiscence.A total of 86 patients (98.9%) were followed over a mean period of 24.5 +/- 0.5 months. Survival, angina-free period and period free of any coronary event at 5 years were 97 +/- 0.05%, 89 +/- 0.1% and 87 +/- 0.1% respectively (mean +/- standard error, CI 95%). On multivariate analysis, the presence of peripheral vascular disease (p < 0.015) and the development of low cardiac output (p < 0.04) or atrial fibrillation (p < 0.04) during the postoperative period were predictive factors for the appearance of coronary events during follow-up., Conclusions: Surgery exclusively with arterial grafts achieves good medium term results in relation to survival and time free of coronary events.
- Published
- 2000
- Full Text
- View/download PDF
29. Compound grafts of xenopericardium and Dacron fabric for repair or replacement of great vessels: a method to avoid interstitial and suture hole bleeding.
- Author
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Nuñez L, Gil-Aguado M, Pinto AG, Larrea JL, and Tamames S
- Subjects
- Adolescent, Adult, Aged, Aorta, Thoracic surgery, Child, Female, Hemorrhage prevention & control, Humans, Male, Middle Aged, Pericardium transplantation, Polyethylene Terephthalates therapeutic use, Postoperative Complications prevention & control, Transplantation, Heterologous, Aortic Aneurysm surgery, Aortic Diseases surgery
- Abstract
Compound grafts constructed by wrapping pericardial xenografts around fabric grafts were used for replacement or repair of the great vessels. After cardiopulmonary bypass (CPB), bleeding through the compound graft is nil. Nine patients had the intrathoracic aorta replaced with a compound graft, and eight patients had patch repair of the ascending aorta or the right ventricular outflow tract. Bleeding in all patients was minimal because the nonporous nature of the xenopericardium avoids interstitial and suture hole hemorrhage until normal hemostasis is obtained.
- Published
- 1984
30. Enlargement of the aortic annulus by resecting the commissure between the left and noncoronary cusps.
- Author
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Nuñez L, Aguado MG, Pinto AG, and Larrea JL
- Published
- 1983
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