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Objective: To evaluate the effect of asiaticoside on streptozotocin (STZ) and nicotinamide (NAD)-induced carbohydrate metabolism abnormalities and deregulated insulin signaling pathways in rats. Methods: Asiaticoside (50 and 100 mg/kg body weight) was administered to STZ-NAD-induced diabetic rats for 45 days, and its effects on hyperglycaemic, carbohydrate metabolic, and insulin signaling pathway markers were examined. Results: Asiaticoside increased insulin production, lowered blood glucose levels, and enhanced glycolysis by improving hexokinase activity and suppressing glucose-6-phosphatase and fructose-1,6-bisphosphatase activities. Abnormalities in glycogen metabolism were mitigated by increasing glycogen synthase activity and gluconeogenesis was decreased by decreasing glycogen phosphorylase activity. Furthermore, asiaticoside upregulated the mRNA expressions of IRS-1, IRS-2, and GLUT4 in STZ-NAD-induced diabetic rats and restored the beta cell morphology to normal. Conclusions: Asiaticoside has the potential to ameliorate type 2 diabetes by improving glycolysis, gluconeogenesis, and insulin signaling pathways. [ABSTRACT FROM AUTHOR]

BACKGROUND: Cardiovascular disease has now become the leading cause of mortality in India. The primary cause of death in most of the developed nations is CHD, despite improvements in diagnostic and therapeutic procedures. The electrocardiogram's left bundle-branch block could mask the alterations caused by MI which delays the management. MAIN TEXT AIMS AND OBJECTIVES: To understand the significance of bundle branch block. To estimate the incidence of bundle branch block and its prognosis in acute coronary syndrome. PATIENTS AND METHODS: A prospective analytical study was done on 150 patients over 18 months with patients with angina chest pain admitted to the coronary care unit. Patients with known bundle branch block and previous coronary artery disease are excluded from the study results Right bundle branch block may occur normally in healthy individuals but when it is associated with acute coronary syndrome it indicates poor prognosis compared to the left bundle branch block. [ABSTRACT FROM AUTHOR]

Background: Cleaning and shaping represent a vital step in the endodontic procedure. In routine endodontic therapy, the fracture of nickel–titanium (NiTi) instruments is a procedural problem creating a major obstacle to therapy. Aim: This study examines the life span of one Neoendo Flex and ProTaper Next (PTN) rotary file using reciprocating motion and compares the time required by both file systems for canal preparation. Materials and Methods: One hundred maxillary permanent central incisors were selected. In that, fifty teeth are utilized in a reciprocating motion (RM) with the PTN file (n = 25) and Neoendo Flex file (n = 25). To check fractured resistance and the overall root canal preparation time, fifty more teeth are employed in continuous motion (CM) with canals prepared using PTN (n = 25) and Neoendo Flex (n = 25). All canals are prepared following the sequence of respective files. Later, the fracture mechanism of the files was inspected using a scanning electron microscope. Results: In an RM motion, both PTN and Neoendo Flex files can be used in a minimum of 25 canals in single-rooted teeth. Statistical analysis using the Mann–Whitney U -test showed no significant difference in total time taken by PTN and Neoendo Flex in both motions. Conclusion: Within the limitation of this study, the RM was found to be better than CM with less incidence of instrument fracture. [ABSTRACT FROM AUTHOR]

Aim: To compare the effectiveness of Apex Locators and Endomotor with built-in Apex Locators for determining the working length in root canal treatment., Methods: A total of 120 patients were randomly assigned to three groups: Group 1 (Root ZX Mini Apex Locator), Group 2 (Minipex Apex Locator), and Group 3 (Endopilot Endomotor with built-in Apex Locator). Working length was determined using respective devices, followed by canal preparation and radiographic confirmation with a master cone., Results: There was no statistically significant difference in working length determination between Apex Locators and Endomotor with built-in Apex Locators. Acceptable working length was achieved in 105 out of 120 cases., Conclusion: The Root ZX Mini, Minipex, and Endopilot demonstrated comparable efficacy in determining working length during root canal treatment. These devices offer reliable alternatives to traditional radiographic methods, providing clinicians with accurate measurements and contributing to successful treatment outcomes., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Journal of Pharmacy and Bioallied Sciences.)