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1. Development of Quantum Limited Superconducting Amplifiers for Advanced Detection

Author

S. Pagano, C. Barone, M. Borghesi, W. Chung, G. Carapella, A. P. Caricato, I. Carusotto, A. Cian, D. Di Gioacchino, E. Enrico, P. Falferi, L. Fasolo, M. Faverzani, E. Ferri, G. Filatrella, C. Gatti, A. Giachero, D. Giubertoni, A. Greco, C. Kutlu, A. Leo, C. Ligi, G. Maccarrone, B. Margesin, G. Maruccio, A. Matlashov, C. Mauro, R. Mezzena, A. G. Monteduro, A. Nucciotti, L. Oberto, V. Pierro, L. Piersanti, M. Rajteri, A. Rettaroli, S. Rizzato, Y. K. Semertzidis, S. Uchaikin, A. Vinante, Pagano, Sergio, Barone, Carlo, Borghesi, Matteo, Chung, Woohyun, Carapella, Giovanni, Caricato, Anna Paola, Carusotto, Iacopo, Cian, Alessandro, Di Gioacchino, Daniele, Enrico, Emanuele, Falferi, Paolo, Fasolo, Luca, Faverzani, Marco, Ferri, Elena, Filatrella, Giovanni, Gatti, Claudio, Giachero, Andrea, Giubertoni, Damiano, Greco, Angelo, Kutlu, Caglar, Leo, Angelo, Ligi, C., Maccarrone, Giovanni, Margesin, Benno, Maruccio, Giuseppe, Matlashov, Andrei, Mauro, Costantino, Mezzena, Renato, Monteduro, Anna Grazia, Nucciotti, Angelo, Oberto, Luca, Pierro, Vincenzo, Piersanti, Luca, Rajteri, Mauro, Rizzato, Silvia, Semertzidis, Yannis K, Uchaikin, Sergey V., Vinante, Andrea, Pagano, S, Barone, C, Borghesi, M, Chung, W, Carapella, G, Caricato, A, Carusotto, I, Cian, A, Di Gioacchino, D, Enrico, E, Falferi, P, Fasolo, L, Faverzani, M, Ferri, E, Filatrella, G, Gatti, C, Giachero, A, Giubertoni, D, Greco, A, Kutlu, C, Leo, A, Ligi, C, Maccarrone, G, Margesin, B, Maruccio, G, Matlashov, A, Mauro, C, Mezzena, R, Monteduro, A, Nucciotti, A, Oberto, L, Pierro, V, Piersanti, L, Rajteri, M, Rizzato, S, Semertzidis, Y, Uchaikin, S, and Vinante, A

Subjects
Josephson junctions, Superconducting microwave devices, Microwave amplifiers, Physics, superconducting microwave device, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Physics, Superconducting microwave devices,Bandwidth, Power transmission lines, Josephson junctions, Microwave amplifiers, Inductance, Bandwidth, Josephson junction, Power transmission lines, Superconducting device noise, microwave amplifier, Electrical and Electronic Engineering, Inductance
Abstract

Ultralow-noise microwave amplification and detection play a central role in different applications, going from fundamental physics experiments to the deployment of quantum technologies. In many applications the necessity of reading multiple detectors, or cavities or qubits, calls for large bandwidth amplifiers with the lowest possible noise. Current technologies are based on High Electron Mobility Transistors and Josephson Parametric Amplifiers. Both have limitations, the former in terms of the minimum noise, the latter in terms of bandwidth. Superconducting Traveling Wave Parametric Amplifiers (TWPAs) have the potential of offering quantum limited noise and large bandwidth. These amplifiers are based on the parametric amplification of microwaves traveling along a transmission line with embedded nonlinear elements. We are developing superconducting TWPAs based both on Josephson junction arrays (Traveling Wave Josephson Parametric mplifiers) and on nonlinear kinetic inductance (Dispersion Engineered Traveling Wave Kinetic Inductance Amplifiers). Our goal is to achieve large bandwidth (in the 5 to 10 GHz range), large gain (more than 20 dB), large saturation power (more than -50 dBm), and near quantum limited noise (noise temperature less than 600 mK). Current achievements in the design and development of the high performance TWPAs are here reported and discussed, together with current limitations and possible future developments.

Published
2022
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2. Progress in the development of a KITWPA for the DARTWARS project

Author

M. Borghesi, C. Barone, S. Capelli, G. Carapella, A.P. Caricato, I. Carusotto, A. Cian, D. Di Gioacchino, E. Enrico, P. Falferi, L. Fasolo, M. Faverzani, E. Ferri, G. Filatrella, C. Gatti, A. Giachero, D. Giubertoni, V. Granata, A. Greco, C. Guarcello, D. Labranca, A. Leo, C. Ligi, G. Maccarrone, F. Mantegazzini, B. Margesin, G. Maruccio, C. Mauro, R. Mezzena, A.G. Monteduro, A. Nucciotti, L. Oberto, L. Origo, S. Pagano, V. Pierro, L. Piersanti, M. Rajteri, A. Rettaroli, S. Rizzato, A. Vinante, M. Zannoni, Borghesi, M, Barone, C, Capelli, S, Carapella, G, Caricato, A, Carusotto, I, Cian, A, Di Gioacchino, D, Enrico, E, Falferi, P, Fasolo, L, Faverzani, M, Ferri, E, Filatrella, G, Gatti, C, Giachero, A, Giubertoni, D, Granata, V, Greco, A, Guarcello, C, Labranca, D, Leo, A, Ligi, C, Maccarrone, G, Mantegazzini, F, Margesin, B, Maruccio, G, Mauro, C, Mezzena, R, Monteduro, A, Nucciotti, A, Oberto, L, Origo, L, Pagano, S, Pierro, V, Piersanti, L, Rajteri, M, Rettaroli, A, Rizzato, S, Vinante, A, and Zannoni, M

Subjects
Superconductivity (cond-mat.supr-con), Nuclear and High Energy Physics, Quantum Physics, KITWPA, Condensed Matter - Superconductivity, Superconducting circuit, Parametric amplifier, Readout, Superconducting circuits, FOS: Physical sciences, Quantum Physics (quant-ph), Instrumentation
Abstract

DARTWARS (Detector Array Readout with Traveling Wave AmplifieRS) is a three years project that aims to develop high-performing innovative Traveling Wave Parametric Amplifiers (TWPAs) for low temperature detectors and qubit readout (C-band). The practical development follows two different promising approaches, one based on the Josephson junctions (TWJPA) and the other one based on the kinetic inductance of a high-resistivity superconductor (KITWPA). This paper presents the advancements made by the DARTWARS collaboration to produce a first working prototype of a KITWPA., 3 pages, 4 figures. Proceeding of Pisa15th Meeting conference

Published
2022

3. Detector Array Readout with Traveling Wave Amplifiers

Author

A. Giachero, C. Barone, M. Borghesi, G. Carapella, A. P. Caricato, I. Carusotto, W. Chang, A. Cian, D. Di Gioacchino, E. Enrico, P. Falferi, L. Fasolo, M. Faverzani, E. Ferri, G. Filatrella, C. Gatti, D. Giubertoni, A. Greco, C. Kutlu, A. Leo, C. Ligi, G. Maccarrone, B. Margesin, G. Maruccio, A. Matlashov, C. Mauro, R. Mezzena, A. G. Monteduro, A. Nucciotti, L. Oberto, S. Pagano, V. Pierro, L. Piersanti, M. Rajteri, S. Rizzato, Y. K. Semertzidis, S. Uchaikin, A. Vinante, Giachero, A., Barone, C., Borghesi, M., Carapella, G., Caricato, A. P., Carusotto, I., Chang, W., Cian, A., Di Gioacchino, D., Enrico, E., Falferi, P., Fasolo, L., Faverzani, M., Ferri, E., Filatrella, G., Gatti, C., Giubertoni, D., Greco, A., Kutlu, C., Leo, A., Ligi, C., Maccarrone, G., Margesin, B., Maruccio, Giuseppe, Matlashov, A., Mauro, C., Mezzena, R., Monteduro, A. G., Nucciotti, A., Oberto, L., Pagano, S., Pierro, V., Piersanti, L., Rajteri, M., Rizzato, S., Semertzidis, Y. K., Uchaikin, S., Vinante, A., Giachero, A, Barone, C, Borghesi, M, Carapella, G, Caricato, A, Carusotto, I, Chang, W, Cian, A, Gioacchino, D, Enrico, E, Falferi, P, Fasolo, L, Faverzani, M, Ferri, E, Filatrella, G, Gatti, C, Giubertoni, D, Greco, A, Kutlu, C, Leo, A, Ligi, C, Maccarrone, G, Margesin, B, Maruccio, G, Matlashov, A, Mauro, C, Mezzena, R, Monteduro, A, Nucciotti, A, Oberto, L, Pagano, S, Pierro, V, Piersanti, L, Rajteri, M, Rizzato, S, Semertzidis, Y, Uchaikin, S, and Vinante, A

Subjects
Quantum Physics, Quantum noise, Parametric amplifer, Traveling wave, Detector array read out, Qubits read out, Physics::Instrumentation and Detectors, Condensed Matter - Superconductivity, FOS: Physical sciences, Condensed Matter Physics, Parametric amplifier, Atomic and Molecular Physics, and Optics, Superconductivity (cond-mat.supr-con), General Materials Science, Quantum Physics (quant-ph), FIS/04 - FISICA NUCLEARE E SUBNUCLEARE
Abstract

Reducing noise to the quantum limit over a large bandwidth is a fundamental requirement for future applications operating at millikelvin temperatures, such as the neutrino mass measurement, the next-generation X-ray observatory, the CMB measurement, the dark matter and axion detection, and the rapid high-fidelity readout of superconducting qubits. The read out sensitivity of arrays of microcalorimeter detectors, resonant axion-detectors, and qubits, is currently limited by the noise temperature and bandwidth of the cryogenic amplifiers. The Detector Array Readout with Traveling Wave Amplifiers project has the goal of developing high-performing innovative traveling wave parametric amplifiers with a high gain, a high saturation power, and a quantum-limited or nearly quantum-limited noise. The practical development follows two different promising approaches, one based on the Josephson junctions and the other one based on the kinetic inductance of a high-resistivity superconductor. In this contribution, we present the aims of the project, the adopted design solutions and preliminary results from simulations and measurements.

Published
2022

4. Ultra low noise readout with traveling wave parametric amplifiers: The DARTWARS project

Author

A. Rettaroli, C. Barone, M. Borghesi, S. Capelli, G. Carapella, A.P. Caricato, I. Carusotto, A. Cian, D. Di Gioacchino, E. Enrico, P. Falferi, L. Fasolo, M. Faverzani, E. Ferri, G. Filatrella, C. Gatti, A. Giachero, D. Giubertoni, V. Granata, A. Greco, C. Guarcello, D. Labranca, A. Leo, C. Ligi, G. Maccarrone, F. Mantegazzini, B. Margesin, G. Maruccio, C. Mauro, R. Mezzena, A.G. Monteduro, A. Nucciotti, L. Oberto, L. Origo, S. Pagano, V. Pierro, L. Piersanti, M. Rajteri, S. Rizzato, A. Vinante, M. Zannoni, Rettaroli, A, Barone, C, Borghesi, M, Capelli, S, Carapella, G, Caricato, A, Carusotto, I, Cian, A, Di Gioacchino, D, Enrico, E, Falferi, P, Fasolo, L, Faverzani, M, Ferri, E, Filatrella, G, Gatti, C, Giachero, A, Giubertoni, D, Granata, V, Greco, A, Guarcello, C, Labranca, D, Leo, A, Ligi, C, Maccarrone, G, Mantegazzini, F, Margesin, B, Maruccio, G, Mauro, C, Mezzena, R, Monteduro, A, Nucciotti, A, Oberto, L, Origo, L, Pagano, S, Pierro, V, Piersanti, L, Rajteri, M, Rizzato, S, Vinante, A, and Zannoni, M

Subjects
Quantum Physics, Nuclear and High Energy Physics, Josephson junctions, Microwaves, Low noise, Parametric amplification, Detector arrays, Superconductors, FOS: Physical sciences, Detector array, Josephson junction, Superconductor, Quantum Physics (quant-ph), Microwave, Instrumentation
Abstract

The DARTWARS project has the goal of developing high-performing innovative travelling wave parametric amplifiers with high gain, large bandwidth, high saturation power, and nearly quantum-limited noise. The target frequency region for its applications is 5 - 10 GHz, with an expected noise temperature of about 600 mK. The development follows two different approaches, one based on Josephson junctions and one based on kinetic inductance of superconductors. This contribution mainly focuses on the Josephson travelling wave parametric amplifier, presenting its design, preliminary measurements and the test of homogeneity of arrays of Josephson junctions., 4 pages, 5 figures. Proceeding of Pisa15th Meeting conference. arXiv admin note: text overlap with arXiv:2111.03409

Published
2023
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5. Mechanotransduction Impairment in Primary Fibroblast Model of Krabbe Disease.

Author

Mezzena R, Del Grosso A, Pellegrino RM, Alabed HBR, Emiliani C, Tonazzini I, and Cecchini M

Abstract

Krabbe disease (KD) is a genetic disorder caused by the absence of the galactosylceramidase (GALC) functional enzyme. No cure is currently available. Here, we investigate the mechanotransduction process in primary fibroblasts collected from the twitcher mouse, a natural KD murine model. Thanks to mechanotransduction, cells can sense their environment and convert external mechanical stimuli into biochemical signals that result in intracellular changes. In GALC-deficient fibroblasts, we show that focal adhesions (FAs), the protein clusters necessary to adhere and migrate, are increased, and that single-cell migration and wound healing are impaired. We also investigate the involvement of the autophagic process in this framework. We show a dysregulation in the FA turnover: here, the treatment with the autophagy activator rapamycin boosts cell migration and improves the clearance of FAs in GALC-deficient fibroblasts. We propose mechanosensing impairment as a novel potential pathological mechanism in twitcher fibroblasts, and more in general in Krabbe disease.

Published
2023
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6. Perturbation of Cortical Excitability in a Conditional Model of PCDH19 Disorder.

Author

Lamers D, Landi S, Mezzena R, Baroncelli L, Pillai V, Cruciani F, Migliarini S, Mazzoleni S, Pasqualetti M, Passafaro M, Bassani S, and Ratto GM

Subjects
Animals, Cadherins genetics, Female, Male, Mice, Mosaicism, Protocadherins, Cortical Excitability, Epilepsy genetics
Abstract

PCDH19 epilepsy (DEE9) is an X-linked syndrome associated with cognitive and behavioral disturbances. Since heterozygous females are affected, while mutant males are spared, it is likely that DEE9 pathogenesis is related to disturbed cell-to-cell communication associated with mosaicism. However, the effects of mosaic PCDH19 expression on cortical networks are unknown. We mimicked the pathology of DEE9 by introducing a patch of mosaic protein expression in one hemisphere of the cortex of conditional PCDH19 knockout mice one day after birth. In the contralateral area, PCDH19 expression was unaffected, thus providing an internal control. In this model, we characterized the physiology of the disrupted network using local field recordings and two photon Ca 2+ imaging in urethane anesthetized mice. We found transient episodes of hyperexcitability in the form of brief hypersynchronous spikes or bursts of field potential oscillations in the 9-25 Hz range. Furthermore, we observed a strong disruption of slow wave activity, a crucial component of NREM sleep. This phenotype was present also when PCDH19 loss occurred in adult mice, demonstrating that PCDH19 exerts a function on cortical circuitry outside of early development. Our results indicate that a focal mosaic mutation of PCDH19 disrupts cortical networks and broaden our understanding of DEE9.

Published
2022
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7. Chitosan Micro-Grooved Membranes with Increased Asymmetry for the Improvement of the Schwann Cell Response in Nerve Regeneration.

Author

Scaccini L, Mezzena R, De Masi A, Gagliardi M, Gambarotta G, Cecchini M, and Tonazzini I

Subjects
Cell Movement, Cell Proliferation, Humans, Neurilemmoma pathology, Chitosan chemistry, Membranes chemistry, Nerve Regeneration, Neurilemmoma therapy, Schwann Cells cytology, Wound Healing
Abstract

Peripheral nerve injuries are a common condition in which a nerve is damaged, affecting more than one million people every year. There are still no efficient therapeutic treatments for these injuries. Artificial scaffolds can offer new opportunities for nerve regeneration applications; in this framework, chitosan is emerging as a promising biomaterial. Here, we set up a simple and effective method for the production of micro-structured chitosan films by solvent casting, with high fidelity in the micro-pattern reproducibility. Three types of chitosan directional micro-grooved patterns, presenting different levels of symmetricity, were developed for application in nerve regenerative medicine: gratings (GR), isosceles triangles (ISO) and scalene triangles (SCA). The directional patterns were tested with a Schwann cell line. The most asymmetric topography (SCA), although it polarized the cell shaping less efficiently, promoted higher cell proliferation and a faster cell migration, both individually and collectively, with a higher directional persistence of motion. Overall, the use of micro-structured asymmetrical directional topographies may be exploited to enhance the nerve regeneration process mediated by chitosan scaffolds.

Published
2021
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8. Chitosan films for regenerative medicine: fabrication methods and mechanical characterization of nanostructured chitosan films.

Author

De Masi A, Tonazzini I, Masciullo C, Mezzena R, Chiellini F, Puppi D, and Cecchini M

Abstract

Regenerative medicine is continuously facing new challenges and it is searching for new biocompatible, green/natural polymer materials, possibly biodegradable and non-immunogenic. Moreover, the critical importance of the nano/microstructuring of surfaces is overall accepted for their full biocompatibility and in vitro/in vivo performances. Chitosan is emerging as a promising biopolymer for tissue engineering and its application can be further improved by exploiting its nano/microstructuration. Here, we report the state of the art of chitosan films and scaffolds nano/micro-structuration. We show that it is possible to obtain, by solvent casting, chitosan thin films with good mechanical properties and to structure them at the microscale and even nanoscale level, with resolutions down to 100 nm.

Published
2019
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