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208 results on '"Raffort, Juliette"'

1. Open E-survey on the Use and Perception of Chatbots in Vascular Surgery

Author

Enzmann, Florian, de Borst, Gert J., Sousa, Joel Ferreira, Meecham, Lewis, Domingos, Liliana, Teraa, Martin, Zlatanovic, Petar, Weiss, Salome, Ancetti, Stefano, Busch, Albert, Jóhannesdóttir, Bergrós, Gombert, Alexander, Noronen, Katariina, Hinchliffe, Robert, Predenciuc, Alexandru, Doukas, Panagiotis, Kukulski, Leszek, Ghulam, Qasam, Karelis, Angelos, Darwish, Maram, Barbati, Mohammad Esmaeil, Møller, Markvard, Spreadbury, Matt, van de Water, Willemien, van den Hondel, Desiree, Ebben, Harm, Croo, Alexander, Uijtterhaegen, Gilles, Trusca, Adina, Melo, Ryan Gouveia, Dabravolskaite, Vaiva, Spath, Paolo, Amlani, Vishal, Kiernan, Aoife, Zielasek, Christian, Lareyre, Fabien, D'Oria, Mario, Caradu, Caroline, Jongkind, Vincent, Di Lorenzo, Gilles, Smeds, Matthew R., Nasr, Bahaa, and Raffort, Juliette

Published
2024
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4. A Nationwide Analysis in France on Sex Difference and Outcomes Following Carotid Intervention in Asymptomatic Patients.

Author

Lareyre, Fabien, Raffort, Juliette, Tulamo, Riikka, de Borst, Gert J., Behrendt, Christian-Alexander, Pradier, Christian, Fabre, Roxane, and Bailly, Laurent

Subjects
*TRANSIENT ischemic attack, *ASYMPTOMATIC patients, *NATIONAL health insurance, *CAROTID artery, *STROKE
Abstract

Objective: The impact of sex on outcomes following carotid endarterectomy (CEA) and carotid artery stenting (CAS) is not fully elucidated. The aim of this study was to analyze the association between sex and outcomes of asymptomatic patients who underwent primary carotid interventions in France. Methods: This nationwide retrospective study was performed using the French National Health Insurance Information System and included asymptomatic patients who underwent primary carotid intervention over a 10-year period (1 January 2013 to 31 August 2023). Symptomatic patients and patients who had peri-operative neurologic events were excluded. The primary endpoints were the occurrence of death and stroke/transient ischaemic attack (TIA) at 30 days, 1 and 5 years after patients' discharge. Results: In total, 115,879 patients were admitted for an index CEA (29.4% women) and 6500 for CAS (29.8% women). In the CEA group, no significant sex-related difference was observed for 30-day mortality; however, women had significantly lower 1-year and 5-year mortality rates compared to men (1.9% vs. 2.6%, p < 0.001 and 7.9% vs. 11.1%, p < 0.001). In the CAS group, women had lower 30-day, 1-year and 5-year mortality (0.6% vs. 1.0%, p = 0.040, 3.8% vs. 4.9%, p = 0.048, and 10.4% vs. 15.0%, p < 0.001). A multivariate analysis showed that sex was not associated with the risk of stroke/TIA and mortality at 30 days (OR 0.84 (95% CI 0.67–1.04) and 1.27 (95% CI 0.98–1.64)). Male sex was associated with a higher risk of 1-year and 5-year mortality (OR 1.24 (95% CI 1.13–1.36) and 1.25 (95% CI 1.18–1.31)), but a lower risk of stroke/TIA than female sex. Conclusions: No significant sex-related difference was observed at 30 days in patients being discharged alive and without peri-operative neurologic events. Male sex was associated with a higher risk of mortality but a lower risk of stroke/TIA at 1 and 5 years. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Serum S100B Level in the Management of Pediatric Minor Head Trauma

Author

Bouvier, Damien, primary, Cantais, Aymeric, additional, Laspougeas, Alban, additional, Lorton, Fleur, additional, Plenier, Yannick, additional, Cottier, Maria, additional, Fournier, Philippe, additional, Tran, Antoine, additional, Moreau, Emilie, additional, Durif, Julie, additional, Sarret, Catherine, additional, Mourgues, Charline, additional, Sturtz, Franck, additional, Oudart, Jean-Baptiste, additional, Raffort, Juliette, additional, Gonzalo, Philippe, additional, Cristol, Jean-Paul, additional, Masson, Damien, additional, Pereira, Bruno, additional, and Sapin, Vincent, additional

Published
2024
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12. Automatic Detection of Visceral Arterial Aneurysms on Computed Tomography Angiography Using Artificial Intelligence Based Segmentation of the Vascular System

Author

Lareyre, Fabien, primary, Caradu, Caroline, additional, Chaudhuri, Arindam, additional, Lê, Cong Duy, additional, Di Lorenzo, Gilles, additional, Adam, Cédric, additional, Carrier, Marion, additional, Raffort, Juliette, additional, Coscas, Raphaël, additional, Jayet, Jérémie, additional, Soler, Raphaël, additional, and Salomon du Mont, Lucie, additional

Published
2023
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14. Artificial intelligence–based predictive models in vascular diseases

Author

Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Lareyre, Fabien, Chaudhuri, Arindam, Behrendt, Christian Alexander, Pouhin, Alexandre, Teraa, Martin, Boyle, Jonathan R., Tulamo, Riikka, Raffort, Juliette, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Lareyre, Fabien, Chaudhuri, Arindam, Behrendt, Christian Alexander, Pouhin, Alexandre, Teraa, Martin, Boyle, Jonathan R., Tulamo, Riikka, and Raffort, Juliette

Published
2023

15. TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm

Author

Vandestienne, Marie, Zhang, Yujiao, Santos-Zas, Icia, Al-Rifai, Rida, Joffre, Jeremie, Giraud, Andreas, Laurans, Ludivine, Esposito, Bruno, Pinet, Florence, Bruneval, Patrick, Raffort, Juliette, Lareyre, Fabien, Vilar, Jose, Boufenzer, Amir, Guyonnet, Lea, Guerin, Coralie, Clauser, Eric, Silvestre, Jean-Sebastien, Lang, Sylvie, Soulat-Dufour, Laurie, Tedgui, Alain, Mallat, Ziad, Taleb, Soraya, Boissonnas, Alexandre, Derive, Marc, Chinetti, Giulia, and Ait-Oufella, Hafid

Subjects
Monocytes -- Physiological aspects -- Health aspects, Abdominal aneurysm -- Development and progression -- Models, Membrane proteins -- Physiological aspects -- Health aspects, Health care industry
Abstract

The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory responses in several cardiovascular diseases but its role in abdominal aortic aneurysm (AAA) remains unknown. Our objective was to explore the role of TREM-1 in a mouse model of angiotensin Il-induced (AngII-induced) AAA. TREM-1 expression was detected in mouse aortic aneurysm and colocalized with macrophages. Treml gene deletion ([Apoe.sup.-/-] [Trem1.sup.-/-]), as well as TREM-1 pharmacological blockade with LR-12 peptide, limited both AAA development and severity. Treml gene deletion attenuated the inflammatory response in the aorta, with a reduction of Il1b, Tnfa, Mmp2, and Mmp9 mRNA expression, and led to a decreased macrophage content due to a reduction of [Ly6C.sup.hi] classical monocyte trafficking. Conversely, antibody-mediated TREM-1 stimulation exacerbated [Ly6C.sup.hi] monocyte aorta infiltration after AngII infusion through CD62L upregulation and promoted proinflammatory signature in the aorta, resulting in worsening AAA severity. AngII infusion stimulated TREM-1 expression and activation on [Ly6C.sup.hi] monocytes through AngII receptor type I ([AT.sub.1]R). In human AAA, TREM-1 was detected and TREM1 mRNA expression correlated with SELL mRNA expression. Finally, circulating levels of sTREM-1 were increased in patients with AAA when compared with patients without AAA. In conclusion, TREM-1 is involved in AAA pathophysiology and may represent a promising therapeutic target in humans., Introduction Nonsyndromic abdominal aortic aneurysm (AAA) is one of the leading causes of cardiovascular death, particularly in men and women over 60 years of age (1). Other defined risk factors [...]

Published
2021
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44. Artificial intelligence in abdominal aortic aneurysm

Author

Raffort, Juliette, primary, Adam, Cédric, additional, Carrier, Marion, additional, Ballaith, Ali, additional, Coscas, Raphael, additional, Jean-Baptiste, Elixène, additional, Hassen-Khodja, Réda, additional, Chakfé, Nabil, additional, and Lareyre, Fabien, additional

Published
2020
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49. Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates

Author

Paige, Ellie, Clément, Marc, Lareyre, Fabien, Sweeting, Michael, Raffort, Juliette, Grenier, Céline, Finigan, Alison, Harrison, James, Peters, James E, Sun, Benjamin B, Butterworth, Adam S, Harrison, Seamus C, Bown, Matthew J, Lindholt, Jes S, Badger, Stephen A, Kullo, Iftikhar J, Powell, Janet, Norman, Paul E, Scott, D Julian A, Bailey, Marc A, Rose-John, Stefan, Danesh, John, Freitag, Daniel F, Paul, Dirk S, Mallat, Ziad, Sweeting, Michael [0000-0003-0980-8965], Harrison, James [0000-0003-4960-5062], Sun, Ben [0000-0001-6347-2281], Butterworth, Adam [0000-0002-6915-9015], Harrison, Seamus Conor [0000-0003-1480-1143], Danesh, John [0000-0003-1158-6791], Paul, Dirk [0000-0002-8230-0116], Mallat, Ziad [0000-0003-0443-7878], and Apollo - University of Cambridge Repository

Subjects
Polymorphism, Single Nucleotide, Antibodies, Mice, Transforming Growth Factor beta, Animals, Humans, genetics, Interleukin-6, Angiotensin II, Original Articles, Receptors, Interleukin-6, Survival Rate, Disease Models, Animal, interleukins, inflammation, alleles, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Linear Models, cardiovascular system, aortic aneurysm, Biomarkers, Aortic Aneurysm, Abdominal, Signal Transduction
Abstract

Supplemental Digital Content is available in the text., Background: The Asp358Ala variant (rs2228145; A>C) in the IL (interleukin)-6 receptor (IL6R) gene has been implicated in the development of abdominal aortic aneurysms (AAAs), but its effect on AAA growth over time is not known. We aimed to investigate the clinical association between the IL6R-Asp358Ala variant and AAA growth and to assess the effect of blocking the IL-6 signaling pathway in mouse models of aortic aneurysm rupture or dissection. Methods: Using data from 2863 participants with AAA from 9 prospective cohorts, age- and sex-adjusted mixed-effects linear regression models were used to estimate the association between the IL6R-Asp358Ala variant and annual change in AAA diameter (mm/y). In a series of complementary randomized trials in mice, the effect of blocking the IL-6 signaling pathways was assessed on plasma biomarkers, systolic blood pressure, aneurysm diameter, and time to aortic rupture and death. Results: After adjusting for age and sex, baseline aneurysm size was 0.55 mm (95% CI, 0.13–0.98 mm) smaller per copy of the minor allele [C] of the Asp358Ala variant. Change in AAA growth was −0.06 mm per year (−0.18 to 0.06) per copy of the minor allele; a result that was not statistically significant. Although all available worldwide data were used, the genetic analyses were not powered for an effect size as small as that observed. In 2 mouse models of AAA, selective blockage of the IL-6 trans-signaling pathway, but not combined blockage of both, the classical and trans-signaling pathways, was associated with improved survival (P

Published
2019
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50. Interleukin-6 Receptor and Abdominal Aortic Aneurysm Growth Rates

Author

Paige, Ellie, Clément, Marc, Lareyre, Fabien, Sweeting, Michael, Raffort, Juliette, Grenier, Céline, Finigan, Alison, Harrison, James, Peters, James E., Sun, Benjamin B., Butterworth, Adam, Paige, Ellie, Clément, Marc, Lareyre, Fabien, Sweeting, Michael, Raffort, Juliette, Grenier, Céline, Finigan, Alison, Harrison, James, Peters, James E., Sun, Benjamin B., and Butterworth, Adam

Abstract

The Asp358Ala variant (rs2228145; A>C) in the IL (interleukin)-6 receptor (IL6R) gene has been implicated in the development of abdominal aortic aneurysms (AAAs), but its effect on AAA growth over time is not known. We aimed to investigate the clinical association between the IL6R-Asp358Ala variant and AAA growth and to assess the effect of blocking the IL-6 signaling pathway in mouse models of aortic aneurysm rupture or dissection.

Published
2019

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