40 results on '"Rajagopal, Mogana"'
Search Results
2. Review: An Overview on the Pathogenesis of Cervical Cancer
- Author
-
Tan, Lee Fang, Rajagopal, Mogana, and Selvaraja, Malarvili
- Published
- 2023
- Full Text
- View/download PDF
3. Review of Malaysian medicinal plants with potential wound healing activity
- Author
-
Wiart, Christophe, Tan, Puay Luan, Rajagopal, Mogana, Chew, Yik-Ling, Leong, Mun Yee, Tan, Lee Fang, and Yap, Vi Lien
- Published
- 2024
- Full Text
- View/download PDF
4. Evaluation of phytochemicals and antioxidant potential of a new polyherbal formulation TC-16: additive, synergistic or antagonistic?
- Author
-
Yap, Vi Lien, Tan, Lee Fang, Rajagopal, Mogana, Wiart, Christophe, Selvaraja, Malarvili, Leong, Mun Yee, and Tan, Puay Luan
- Published
- 2023
- Full Text
- View/download PDF
5. Quantitative methods in the analysis of clozapine in human matrices – A scoping review
- Author
-
Lim Jia Le, Rajagopal Mogana, Akowuah Gabriel Akyirem, Keshavarzi Fazlollah, and Alakhali Khaled Mohammed Ahmed
- Subjects
clozapine ,scoping review ,analysis ,quantification ,chromatography ,Chemistry ,QD1-999 - Abstract
Clozapine (CLZ) has retained its clinical utility in the management of schizophrenia despite the discovery of novel antipsychotics, as it possesses unique efficacy in the setting of treatment resistant schizophrenia while causing minimal extrapyramidal symptoms. However, these benefits are offset by the risk of agranulocytosis and other side effects, and therapeutic drug monitoring (TDM) is routinely recommended for patients undergoing treatment with CLZ. A multitude of approaches for the quantification of CLZ have been developed for different settings such as TDM, quality control of pharmaceutical dosage forms, and toxicology studies. Primarily, these approaches fall under one of three branches of analysis, namely, chromatography, electrochemical analysis, and spectrophotometry. This study provides a scoping review of the recent advances in the methods of quantification for CLZ and highlights the potential utility of novel methods in the field of drug quantification.
- Published
- 2024
- Full Text
- View/download PDF
6. COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens
- Author
-
Raj, Sterlin T., primary, Bruce, Alexander W., additional, Anbalagan, Muralidharan, additional, Srinivasan, Hemalatha, additional, Chinnappan, Sasikala, additional, Rajagopal, Mogana, additional, Khanna, Kushagra, additional, Chandramoorthy, Harish C., additional, and Mani, Ravishankar Ram, additional
- Published
- 2024
- Full Text
- View/download PDF
7. Exploration of biomarkers for the diagnosis, treatment and prognosis of cervical cancer: a review
- Author
-
Arip, Masita, Tan, Lee Fang, Jayaraj, Rama, Abdullah, Maha, Rajagopal, Mogana, and Selvaraja, Malarvili
- Published
- 2022
- Full Text
- View/download PDF
8. Assessment of prevalence, knowledge and health-related practices of dysmenorrhea among Malaysian women in Kuala Lumpur: a cross-sectional survey
- Author
-
Mohamad Bakro, Rana, primary, Farrukh, Muhammad Junaid, additional, Rajagopal, Mogana Sundari, additional, Kristina, Susi Ari, additional, Ramatillah, Diana Laila, additional, Ming, Long Chiau, additional, Paneerselvam, Ganesh Sritheran, additional, and Hadi, Muhammad Abdul, additional
- Published
- 2023
- Full Text
- View/download PDF
9. Canarium patentinervium Miq. (Burseraceae kunth.) : a phytochemical and pharmacological study
- Author
-
Rajagopal, Mogana Sundari
- Subjects
615.1 ,RS Pharmacy and materia medica - Abstract
Canarium patentinervium Miq. belongs to the family of Burseraceae best known for producing resins of economic, medicinal, and cultural values such as frankincense, myrrh, and copal. This family consists of 18 genera and 700 species of trees. In the Asia-Pacific region, about 20 species of Burseraceae are used to treat haemorrhoids, heal wounds and to treat skin infections. This plant has been used to heal wounds amongst the indigenous people of Malaysia. Furthermore no pharmacological and phytochemical studies have been reported on this species. This study was undertaken to screen the phytochemical and pharmacological aspects of this plant. Qualitative phytochemical properties of the crude extract was determined for the presence of tannins, flavonoids, alkaloids, saponins or sterols. Phytochemical analysis of Canarium patentinervium Miq. revealed presence of tannins and flavonoids in the ethanol extract of leaves and barks. Bioassay guided fractionation led to isolation of eight secondary metabolites by chromatography which were identified by NMR techniques. Two coumarins (scopoletin and scoparone), five phenols (cynaroside, hyperin, (+)-catechin, lioxin and syringic acid) and a norsesquiterpene with cyclohexenone ring (vomifoliol). The latter three compounds were isolated for the first time from the genus Canarium. The plant and the isolated compounds were then subjected to six biological assays comprising of antibacterial, antioxidant, anticancer, anti-inflammatory, anti-acetylcholinesterase and anti-parasitic activities. Infectious diseases remain the leading cause of death worldwide and bacteria have become more resistant to conventional antibiotic and the search for novel antimicrobial agents from medicinal plants has become crucial. Antibacterial test was done using disc diffusion method, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and death kinetic assay with ampicillin as the positive control. The ethanol extract of leaves and the hexane extract of bark displayed remarkable antibacterial activity against both Gram-positive bacteria and Gram-negative bacteria. All isolated compounds tested against S.aureus ATCC 11632 showed bacterial growth inhibition. Scopoletin, scoparone, hyperin, cynaroside and syringic acid had bactericidal effect <100 µg/ml. Only scopoletin had bactericidal effect and complete kill at MBC 50.00 µg/ml. Bacterial infections have been known to generate extensive formation of free radicals which is becoming increasingly recognized in the pathogenesis of the many human diseases. The role of free radicals and active oxygen is becoming increasingly recognized in the pathogenesis of the many human diseases, including cancer, neurodegenerative diseases, ageing, and atherosclerosis. Five various antioxidant assays with different mode of action [2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), β-carotene bleaching assay and superoxide dismutase (SOD) assay] were used to test the antioxidant scavenging abilities of this plant. Vitamin C (L-ascorbic acid), quercetin and trolox were used as positive controls. The ethanol extract of leaves and barks displayed superior antioxidant capacities. The EC50 values of the samples were consistently low in SET methods (ABTS, DPPH and FRAP) superior to standard as opposed to HAT method (β-carotene bleaching assay). Hyperin and (+)-catechin exhibited the most consistent free radical scavenging capability across the five antioxidant assay. Hyperin and (+)-catechin have significantly lower IC50 (0.75±0.03 µg/ml and 0.94±0.27 µg/ml respectively) compared to SOD enzyme (IC50 1.59±04 µg/ml). Scopoletin exhibited potent antioxidant activity compared to scoparone with significantly lower EC50 values in ABTS (IC50 1.08±0.03 µg/ml) compared to ascorbic acid (EC50 1.54±0.03 µg/ml) and lower values in FRAP assay (FRAP value 49.00±0.64 µg/ml) than quercetin (FRAP value 86.00±0.24 µg/ml) and ascorbic acid (FRAP value 347.00±0.23 µg/ml). Vomifoliol had potent β-carotene bleaching activity with IC50 6.85±0.37 µg/ml. Infections and free radical generation are recognized in the pathogenesis of cancer. The ethanol and chloroform extract of barks showed significant anticancer activities with GI50 values of 34.40µg/ml and 23.44µg/ml. The most susceptible cell lines were found to be the breast cancer cell line, MDA 468. Scopoletin displayed potent anticancer effect against breast cancer cell line MDA 468 (GI50 0.09±0.25 µg/ml) and colorectal cancer cell line HT-29 (GI50 0.17±0.05 µg/ml), the latter being more significant that positive control doxorubicin (GI50 0.66±0.60 µg/ml). In recent years, roles have been identified for several inflammatory cells and for a large number of inflammatory mediators in important pathologies not previously linked to inflammation, such as Alzheimer’s disease and cardiovascular disorders including atherosclerosis, as well as cancer. Recently, reports have appeared regarding so-called “dual inhibitors,” agents that inhibit not only cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), but also 5-lipoxygenase (5-LOX). Chloroform extract of the barks had the lowest 5-LOX inhibition (IC50=29.53±0.0 3μg/ml) when compared to NDGA (IC50=29.19±0.02 μg/ml). Ethanol extract of leaves had superior COX-1 inhibition (IC50 = 0.60±0.01µg/ml) compared to COX-2 inhibition (IC50 = 1.07±0.01 µg/ml), whereas the barks had superior COX-2 inhibition (IC50 = 9.39±0.03 µg/ml) as opposed to COX-1 (IC50 = 11.41±0.03 µg/ml). All isolated compounds exhibited significantly lower 5-LOX inhibition than NDGA. Scopoletin and scoparone were potent inhibitors of 5-LOX recording lowest IC50 values (IC50 0.34±0.01 µg/ml and 0.20±0.01 µg/ml respectively). However (+)-catechin had a more comprehensive anti-inflammatory activity with dual inhibition of 5-LOX (IC50 16.10±0.03 µg/ml) and COX (COX-1; IC50 12.08±0.02 µg/ml, COX-2; IC50 83.89±0.03 µg/ml). Syringic acid exhibited potent 5-LOX inhibition (IC50 1.38±0.03 µg/ml) and moderate COX-1 inhibition (IC50 34.89±0.02 µg/ml). Furthermore, oxidative and inflammatory processes are among the pathological features associated with the central nervous system in Alzheimer’s disease. There is evidence that acetyl cholinesterase (AChE) inhibitors have an anti-inflammatory role through action against free radicals and amyloid toxicity, as well as through decreasing release of cytokines from activated microglia in the brain and blood. Chloroform extract of the barks displayed the best activity (IC50 = 88.59±0.14 μg/ml) as opposed to positive control, galanthamine (IC50 = 0.74±0.06 μg/ml). The ethanol extract of barks and leaves follow through with IC50 = 186.00±0.15 μg/ml and IC50 = 201.24±0.15 μg/ml respectively. Only scopoletin, scoparone, vomifoliol and syringic acid showed AChE inhibition at IC50 <100 µg/ml. Syringic acid exhibited good AChE inhibition (IC50 29.53±0.19 µg/ml), lowest of all compounds tested. Choline is the precursor of phosphatidylcholine (PC), a main component of Leishmania promastigote membranes. Therefore, inhibition of choline formation may de¬crease Leishmania survival. This hypothesis can be tested by using inhibitors of the acetylcholinesterase enzyme (AChE), which catalyzes the hydrolysis of acetylcholine to choline and acetic acid, as leishmanicidal compounds. The hexane extract of leaves showed moderate antileshmanial activity with IC50 values of 257.40±0.30 μg/ml. Only ethanol extracts showed activity against Giardia intestinalis and Entamoeba histolytica at concentration of 500 μg/ml. Scopoletin was tested against all three parasite amd it was more potent against Leishmania donovani (IC50 163.30±0.32 µg/ml) and MIC of >200 µg/ml for both Giardia intestinalis and Entamoeba histolytica. Six kinds of major biological effects were evident in the crude and compounds namely, antioxidant, antibacterial, anti-inflammatory, anti-AChE, anti-parasitic, and anticancer all of which were reported for the first time from this plant. Given the aforementioned evidence it is tempting to speculate that Canarium patentinervium Miq. represents an exciting scaffold from which to develop leads for treatment of inflammatory and oxidative stress related diseases.
- Published
- 2014
10. Antibacterial and Antifungal Terpenes from the Medicinal Angiosperms of Asia and the Pacific: Haystacks and Gold Needles
- Author
-
Wiart, Christophe, primary, Kathirvalu, Geethanjali, additional, Raju, Chandramathi Samudi, additional, Nissapatorn, Veeranoot, additional, Rahmatullah, Mohammed, additional, Paul, Alok K., additional, Rajagopal, Mogana, additional, Sathiya Seelan, Jaya Seelan, additional, Rusdi, Nor Azizun, additional, Lanting, Scholastica, additional, and Sulaiman, Mazdida, additional
- Published
- 2023
- Full Text
- View/download PDF
11. Development of SARS-CoV-2 Vaccine: Challenges and Prospects
- Author
-
Mahboob, Tooba, primary, Ismail, Amni Adilah, additional, Shah, Muhammad Raza, additional, Rahmatullah, Mohammed, additional, Paul, Alok K., additional, Pereira, Maria de Lourdes, additional, Wiart, Christophe, additional, Wilairatana, Polrat, additional, Rajagopal, Mogana, additional, Dolma, Karma G., additional, and Nissapatorn, Veeranoot, additional
- Published
- 2023
- Full Text
- View/download PDF
12. Herbs with Acute Wound Healing Potential: A Review.
- Author
-
Jie Chen Chow, Rajagopal, Mogana, and Choo Shiuan Por
- Subjects
- *
WOUND healing , *CHRONIC wounds & injuries , *DRUG resistance in bacteria , *HERBS , *MEDICINAL plants , *HEALING - Abstract
Wound healing is a timely and orderly process comprised of coagulation, inflammation, proliferative, and remodeling. Any disruption in the physiological process will delay the healing process and result in chronic wounds. Wound cleansing is the standard management for acute wounds to provide an optimal environment for healing. Besides wound cleansers, topical antimicrobials are commonly used to reduce microbial load and prevent microbial infection. However, they are associated with adverse reactions and antibiotic resistance, resulting in delayed wound healing. To overcome the limitations of conventional wound treatment, herbal therapy as an alternative is implemented for wound management with antimicrobial, anti-inflammatory, and antioxidant properties. Following the increased demands of herbal therapy in wound management, the innovative polyherbal formulation has gained popularity and has been extensively studied to promote better wound healing. The combined use of multiple herbs is comparatively cost-effective in providing synergistic effects with minimal side effects. This review provides insight into the role and mechanism of diverse medicinal plants with wound healing potential for acute wound management. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
13. Development of Computational In Silico Model for Nano Lipid Carrier Formulation of Curcumin
- Author
-
Albasri, Omar Waleed Abduljaleel, primary, Kumar, Palanirajan Vijayaraj, additional, and Rajagopal, Mogana Sundari, additional
- Published
- 2023
- Full Text
- View/download PDF
14. Plant as an Alternative Source of Antifungals against Aspergillus Infections: A Review
- Author
-
Tan, Lee Fang, primary, Yap, Vi Lien, additional, Rajagopal, Mogana, additional, Wiart, Christophe, additional, Selvaraja, Malarvili, additional, Leong, Mun Yee, additional, and Tan, Puay Luan, additional
- Published
- 2022
- Full Text
- View/download PDF
15. Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labour
- Author
-
Sulaiman, Mazdida, primary, Zarubaev, Vladimir, additional, Samudi, Chandramathi, additional, Rahmatullah, Mohammed, additional, Jannat, Khoshnur, additional, Paul, Alok, additional, Rajagopal, Mogana, additional, Selvaraja, Malarvili, additional, Nissapatorn, Veeranoot, additional, Suleiman, Monica, additional, Butler, Mark, additional, and Wiart, Christophe, additional
- Published
- 2022
- Full Text
- View/download PDF
16. Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific
- Author
-
Sulaiman, Mazdida, primary, Nissapatorn, Veeranoot, additional, Rahmatullah, Mohammed, additional, Paul, Alok K., additional, Rajagopal, Mogana, additional, Rusdi, Nor Azizun, additional, Seelan, Jaya Seelan Sathya, additional, Suleiman, Monica, additional, Zakaria, Zainul Amiruddin, additional, and Wiart, Christophe, additional
- Published
- 2022
- Full Text
- View/download PDF
17. Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials
- Author
-
Sulaiman, Mazdida, primary, Jannat, Khoshnur, additional, Nissapatorn, Veeranoot, additional, Rahmatullah, Mohammed, additional, Paul, Alok K., additional, de Lourdes Pereira, Maria, additional, Rajagopal, Mogana, additional, Suleiman, Monica, additional, Butler, Mark S., additional, Break, Mohammed Khaled Bin, additional, Weber, Jean-Frédéric, additional, Wilairatana, Polrat, additional, and Wiart, Christophe, additional
- Published
- 2022
- Full Text
- View/download PDF
18. Evidence-Based Management of Uterine Fibroids With Botanical Drugs-A Review
- Author
-
Arip, Masita, primary, Yap, Vi Lien, additional, Rajagopal, Mogana, additional, Selvaraja, Malarvili, additional, Dharmendra, K, additional, and Chinnapan, Sasikala, additional
- Published
- 2022
- Full Text
- View/download PDF
19. Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle
- Author
-
Zulkipli, Masyitah, primary, Mahbub, Nuzum, additional, Fatima, Ayesha, additional, Wan-Lin, Stefanie Lim, additional, Khoo, Teng-Jin, additional, Mahboob, Tooba, additional, Rajagopal, Mogana, additional, Samudi, Chandramathi, additional, Kathirvalu, Gheetanjali, additional, Abdullah, Nor Hayati, additional, Pinho, Ana Rita, additional, Oliveira, Sonia M. R., additional, Pereira, Maria de Lourdes, additional, Rahmatullah, Mohammed, additional, Hasan, Anamul, additional, Paul, Alok K., additional, Butler, Mark S., additional, Nawaz, Muhammad, additional, Wilairatana, Polrat, additional, Nissapatorn, Veeranoot, additional, and Wiart, Christophe, additional
- Published
- 2022
- Full Text
- View/download PDF
20. Phytochemicals and Nano-Phytopharmaceuticals Use in Skin, Urogenital and Locomotor Disorders: Are We There?
- Author
-
Rajagopal, Mogana, primary, Paul, Alok K., additional, Lee, Ming-Tatt, additional, Joykin, Anabelle Rose, additional, Por, Choo-Shiuan, additional, Mahboob, Tooba, additional, Salibay, Cristina C., additional, Torres, Mario S., additional, Guiang, Maria Melanie M., additional, Rahmatullah, Mohammed, additional, Jahan, Rownak, additional, Jannat, Khoshnur, additional, Wilairatana, Polrat, additional, de Lourdes Pereira, Maria, additional, Lim, Chooi Ling, additional, and Nissapatorn, Veeranoot, additional
- Published
- 2022
- Full Text
- View/download PDF
21. Formulation and Physicochemical Evaluation of Green Cosmeceutical Herbal Face Cream Containing Standardized Mangosteen Peel Extract
- Author
-
Tan, Puay Luan, primary, Rajagopal, Mogana, additional, Chinnappan, Sasikala, additional, Selvaraja, Malarvili, additional, Leong, Mun Yee, additional, Tan, Lee Fang, additional, and Yap, Vi Lien, additional
- Published
- 2022
- Full Text
- View/download PDF
22. Review: An Overview on the Pathogenesis of Cervical Cancer.
- Author
-
Lee Fang Tan, Rajagopal, Mogana, and Selvaraja, Malarvili
- Subjects
- *
CARCINOGENESIS , *CERVICAL cancer , *HUMAN papillomavirus , *BREAST , *BREAST cancer , *HISTONE acetylation - Abstract
Cervical cancer (CC) is one of the most common and severe malignant gynaecological tumours affecting women worldwide. It remains a global health burden especially in low- and middle-income countries. In Malaysia, CC is classified as the second most common cancer affecting women following breast cancer. The survival rate of CC in Malaysia is the lowest in Malays, followed by Indians and Chinese. This indicates several factors including age and ethnicity may significantly affect the survival rate among CC patients. Persisting infection with high-risk subtypes of the human papilloma virus (HPV) is the main aetiologic factor for the development of CC in addition to other factors that are involved in the pathogenesis of the disease. Genetic modifications such as loss of heterozygosity, mutation and amplification as well as epigenetic mechanisms such as DNA methylation and histone acetylation have been reported to contribute to CC. Besides, local microbiota and environmental factors including smoking, diet and oxidative stress have been associated with the development and progression of CC. Hormonal dysregulation in CC patients and animal models suggest the role of hormones in cervical carcinogenesis. Increased understanding of CC offers the hope to limit the burden of disease and effective prevention programmes is particularly important as the disease is highly preventable. This article aims to discuss and provide a comprehensive overview on the pathogenesis of CC. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
23. Update on Remdesivir in the Treatment of Novel Coronavirus Pneumonia.
- Author
-
Huang Feng, Lakshmi, K. Vijaya, Chin Tat Ng, Sasikumar, Murthy, Arip, Masita, Hassan, Masriana, Voon Kin Chin, Rajagopal, Mogana, Fatokun, Omotayo, Parvathi, N., and Selvaraja, Malarvili
- Subjects
REMDESIVIR ,COVID-19 pandemic ,DRUG discovery ,THERAPEUTICS ,ANTIVIRAL agents - Abstract
Worldwide epidemic prevention and control remain under significant stress due to the global novel coronavirus disease 2019 (COVID-19) pandemic and the ongoing emergence of variants like Omicron. The total confirmed COVID-19 cases globally as of now topped 620 million, while the total number of fatalities exceeded 6.6 million. The screening, drug discovery, and clinical development of novel treatments are still the hottest subjects in the treatment of COVID-19, and scientists throughout the world are dedicated to identifying prospective therapeutic agents to treat COVID19 patients, including the new uses of old medications. Remdesivir, a COVID-19 therapeutic medication developed by Gilead Sciences, exerts antiviral effects by suppressing the RNA-dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Remdesivir has maintained high inhibitory activity against all existing SARS-CoV-2 variants, including the Omicron variant. We systematically retrieved Web of Science, CNKI, PubMed, and Clinicaltrials.gov to gather information related to Remdesivir on COVID-19 treatment. In this review, we summarized and reviewed the drug targets for COVID-19 management, especially the mechanism of action and research progress of Remdesivir. More importantly, the outcome of current clinical trials of Remdesivir alone and when combined with other drugs for COVID-19 management was analyzed, and the limitations and clinical significance of each clinical trial were evaluated. From this review, we can understand the development progress of Remdesivir for COVID-19 management, deepens the current understanding of Remdesivir research status, and gives us some inspiration for better drug use in COVID-19 management. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
24. Conceptual and Statistical Interpretation of a Systematic Review and Meta-Analysis on Patient Adherence to Lung-RADS–Recommended Screening Intervals in the United States
- Author
-
Rajagopal, Mogana Sundari, Senthilnathan, Raghul, KM, Gothandam, Ram M, Ravishankar, Samiappan, Suja, and Jayaraj, Rama
- Published
- 2022
- Full Text
- View/download PDF
25. A Clinical Investigation on the Theragnostic Effect of MicroRNA Biomarkers for Survival Outcome in Cervical Cancer: A PRISMA-P Compliant Protocol for Systematic Review and Comprehensive Meta-Analysis
- Author
-
Shaw, Peter, primary, Senthilnathan, Raghul, additional, Sankar, Srivarshini, additional, Ilangovan, Ilamathi, additional, Kodiveri Muthukaliannan, Gothandam, additional, Baxi, Siddhartha, additional, Mani, Ravishankar Ram, additional, Rajagopal, Mogana, additional, Chinnappan, Sasikala, additional, Balaraman, Ashok Kumar, additional, Suresh, Deepa, additional, Krishnan, Sunil, additional, Gupta, Madanmohan, additional, Muthusamy, Thangavel, additional, Paranjothy, Chitraabaanu, additional, and Jayaraj, Rama, additional
- Published
- 2022
- Full Text
- View/download PDF
26. Molecular Investigation of miRNA Biomarkers as Chemoresistance Regulators in Melanoma: A Protocol for Systematic Review and Meta-Analysis
- Author
-
Shaw, Peter, primary, Raymond, Greg, additional, Tzou, Katherine S., additional, Baxi, Siddhartha, additional, Mani, Ravishankar Ram, additional, Kumar Govind, Suresh, additional, Chandramoorthy, Harish C., additional, Sivanandy, Palanisamy, additional, Rajagopal, Mogana, additional, Samiappan, Suja, additional, Krishnan, Sunil, additional, and Jayaraj, Rama, additional
- Published
- 2022
- Full Text
- View/download PDF
27. Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol
- Author
-
Shaw, Peter, primary, Raymond, Greg, additional, Senthilnathan, Raghul, additional, Kumarasamy, Chellan, additional, Baxi, Siddhartha, additional, Suresh, Deepa, additional, Shetty, Sameep, additional, Ram M, Ravishankar, additional, Chandramoorthy, Harish C., additional, Sivanandy, Palanisamy, additional, Samiappan, Suja, additional, Rajagopal, Mogana, additional, Krishnan, Sunil, additional, and Jayaraj, Rama, additional
- Published
- 2021
- Full Text
- View/download PDF
28. Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR)
- Author
-
Jubair, Najwan, primary, Rajagopal, Mogana, additional, Chinnappan, Sasikala, additional, Abdullah, Norhayati Binti, additional, and Fatima, Ayesha, additional
- Published
- 2021
- Full Text
- View/download PDF
29. Actitud hacia la práctica profesional entre los farmacéuticos comunitarios en Kuala Lumpur, Malasia
- Author
-
Zakour Khadari, Mohamad, Mohammed Alakhali, Khaled, Rajagopal, Mogana, Baig, Ahsan, and Helweh, Osama
- Subjects
Actitudes ,Farmacéuticos ,Comunidad ,Attitude ,Servicios ,Services ,Malaysia ,Community ,Pharmacists ,Malasia - Abstract
Objetivos: Este estudio se dirigió a evaluar las actitudes de los farmacéuticos comunitarios hacia la práctica profesional y determinar su competencia observada en diversas actividades farmacéuticas. Métodos: estudio transversal realizado en la ciudad de Kuala Lumpur. El cuestionario contenía 40 preguntas divididas en seis secciones que abordaban varios aspectos de la práctica y la información demográfica. En el estudio participaron 223 farmacéuticos con licencia que trabajan en farmacias comunitarias. Los datos se analizaron utilizando SPSS. Se utilizaron pruebas de correlación de Chi-cuadrado y Pearson para determinar la significación estadística de los datos dicotómicos. Hallazgos clave: Entre los 233 encuestados en actividades de gestión, 194 (87%) obtuvieron una puntuación buena y 5 (2,2%) obtuvieron una puntuación mala. En las actividades de dispensación, 199 (89,2%) obtuvieron la puntuación buena y 5 (2,2%) obtuvieron la puntuación mala. En las actividades de atención farmacéutica, 209 (93,7%) obtuvieron una buena puntuación y 4 (1,8%) obtuvieron una mala puntuación. En actividades inter / intraprofesionales, 108 (48,4%) puntuaron bien y 10 (4,5%) puntuaron mal. En las actividades de salud pública, 153 (68,6%) obtuvieron la puntuación buena y 6 (2,7%) obtuvieron la puntuación mala, mientras que en las actividades de mantenimiento de competencias, 160 (71,7%) obtuvieron la puntuación buena y 3 (1,3%) obtuvieron el puntaje pobre. Conclusiones: La mayor parte de los participantes obtuvo una buena actitud fue del 93,7% para las actividades de atención farmacéutica mientras que la mayor de los participantes obtuvo una mala actitud fue del 4,5% para las actividades inter / intraprofesionales. La mayoría de los participantes aceptan las actividades para mantener la competencia, Objectives: This study was directed to evaluate community pharmacists’ attitudes towards professional practice and determine their observed competence in various pharmaceutical activities. Methods: A cross-sectional study conducted in the city of Kuala Lumpur. The questionnaire contained 40 questions splitted into six sections that addressed several aspects of practice and demographic information. The study was involved in 223 licensed pharmacists who work in community pharmacies. Data were analyzed by using SPSS. Chisquare and Pearson’s correlation tests were used for statistical significance for dichotomous data. Key findings: Among the 233 respondents in managerial activities, 194 (87%) achieved the score good, and 5 (2.2%) had the score poor. In dispensing activities, 199 (89.2%) achieved the score good, and 5 (2.2%) had the score poor. In pharmaceutical care activities, 209 (93.7%) got the score good, and 4 (1.8%) got the score poor. In inter/intra professional activities, 108 (48.4%) got the score good, and 10 (4.5%) got the score poor. In public health activities, 153 (68.6%) got the score good, and 6 (2.7%) got the score poor whereas in the maintenance of competency activities, 160 (71.7%) got the score good, and 3 (1.3%) got the score poor. Conclusions: The highest of participants got a good attitude was 93.7% for pharmaceutical care activities while the highest of participants got poor attitude was 4.5% for inter/intra professional activities. The majority of the participants are accepting the activities to maintain competence., This work is supported by UCSI University, Faculty of Pharmaceutical Sciences, Kuala Lumpur Malaysia
- Published
- 2021
30. Attitude towards professional practice among community pharmacists’ in Kuala Lumpur, Malaysia
- Author
-
Alakhali, Khaled Mohammed, primary, Khadari, M Zakour, additional, Rajagopal, Mogana, additional, Baig, Ahsan, additional, and Helweh, Osama, additional
- Published
- 2021
- Full Text
- View/download PDF
31. Course Satisfaction and Perception of Malaysian Provisionally Registered Pharmacists Towards their Training: A Qualitative Study
- Author
-
Hee, Mei Qi, primary, Keshavarzi, Fazlollah, additional, and Rajagopal, Mogana, additional
- Published
- 2020
- Full Text
- View/download PDF
32. Attitude towards professional practice among community pharmacists’ in Kuala Lumpur, Malaysia.
- Author
-
Zakour Khadari, M., Alakhali, Khaled M., Rajagopal, Mogana, Baig, Ahsan, and Helweh, Osama
- Subjects
PROFESSIONAL education ,PHARMACISTS ,DEMOGRAPHIC surveys ,CHI-squared test ,PEARSON correlation (Statistics) ,PHARMACISTS' attitudes - Abstract
Copyright of Ars Pharmaceutica is the property of Facultad de Farmacia de Granada and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
33. Sensitive, Simple, and Quick Method for Simultaneous Quantification of Clozapine and Amlodipine using Reverse Phase HPLC.
- Author
-
Jia Le Lim, Rajagopal, Mogana, Akowuah, Gabriel Akyirem, and Keshavarzi, Fazlollah
- Subjects
- *
AMLODIPINE , *CLOZAPINE , *MALAYSIANS , *HIGH performance liquid chromatography , *PEOPLE with mental illness , *OLANZAPINE , *CALCIUM antagonists , *ARIPIPRAZOLE - Abstract
Hypertension is one of the most prevalent non-communicable diseases in the Malaysian population. In addition, it is associated with various mood and psychiatric disorders such as schizophrenia. Recent studies have shown that hypertension leads to worse clinical outcomes in psychiatric patients. Diverse psychosocial factors caused by schizophrenia also impact hypertension and its clinical care. Clozapine and amlodipine are the hallmark drugs for the treatment of schizophrenia and hypertension, respectively. To date, there is no analytical assay that can simultaneously determine the concentrations of these two drugs in human matrices. An Aquasil C18 column was used in the analysis, with the mobile phase consisting of acetonitrile:water (40:60 v/v) adjusted to pH 4.5 with phosphate buffer. Detection with UV spectrometer was done at 240nm. The method was validated according to the International Council for Harmonization (ICH) guidelines. The calibration curves of clozapine and amlodipine were linear in the range of 100-600 ng/mL and 2-12 ng/mL, respectively (r2>0.99). Clozapine limit of detection (LOD) and limit of quantification (LOQ) were 129.5 ng/mL and 392.4 ng/mL, respectively. Meanwhile, amlodipine achieved LOD of 0.25 ng/mL, and LOQ of 0.75 ng/mL. Overall, the study describes quick, precise and sensitive HPLC-UV method for the simultaneous determination of clozapine and amlodipine in human plasma. [ABSTRACT FROM AUTHOR]
- Published
- 2023
34. Medicinal Herbs for Uterine Fibroids: A Mechanistic Review.
- Author
-
Vi Lien Yap, Rajagopal, Mogana, Selvaraja, Malarvili, Arip, Masita, Kumar, Dharmendra, and Chinnappan, Sasikala
- Subjects
- *
HERBAL medicine , *UTERINE fibroids , *COST effectiveness , *BENIGN tumors , *SEARCH engines - Abstract
Uterine fibroids (UFs) are a common benign gynecological tumor that affect 70-80% of women over their lifetime. Several pharmacological agents are available to reduce the size of fibroids and ameliorate the symptoms of UF. However, these drugs are expensive and are usually associated with profound side effects. Thus, medicinal herbs are gaining attention in this era due to their cost effectiveness with a comparable or more potent therapeutic efficacy while demonstrating lesser adverse effects. Previous studies have extensively explored on the benefits and risks of using medicinal herbs in the treatment of uterine fibroid. However, a detailed review on the mechanism of medicinal herb extracts and polyherbal preparation have not been conducted. The objective of this review is therefore to summarize the available information on the mechanism of various medicinal herbs and polyherbal formulations with anti-uterine fibroid activity. A systematic search was performed using several search engines such as PubMed, Google Scholar, and Science Direct to identify medicinal herbs with anti-uterine fibroid activity. Based on the literatures identified, a total of five medicinal herbs and three polyherbal formulations were included and discussed in this review, which yields useful information regarding the mechanism of different medicinal herbs and polyherbal formulations in exerting anti-uterine fibroid activity for its potential use as an alternative treatment choice for uterine fibroids. [ABSTRACT FROM AUTHOR]
- Published
- 2023
35. Formulation and Physicochemical Evaluation of Green Cosmeceutical Herbal Face Cream Containing Standardized Mangosteen Peel Extract.
- Author
-
Puay Luan Tan, Rajagopal, Mogana, Yik Ling Chew, Chinnappan, Sasikala, Selvaraja, Malarvili, Mun Yee Leong, Lee Fang Tan, and Vi Lien Yap
- Subjects
- *
FACIAL creams (Cosmetics) , *MANGOSTEEN , *TOPICAL drug administration , *SYNTHETIC products , *SUSTAINABLE development , *PHASE separation - Abstract
The widely reported adverse effects of synthetic ingredients encourage the development of green cosmeceuticals to achieve Sustainable Development Goal (SDG) 3. The waste product of mangosteen (mangosteen peel) was utilized in the formulation to reduce waste production corresponding to SDG 12, in addition to its anti-aging and pigmentation control effects. This study aimed to formulate and evaluate novel herbal face creams containing standardized mangosteen peel extract. The mangosteen creams were formulated using natural ingredients and were evaluated for their organoleptic characteristics, rheology, spreadability and pH. Furthermore, an accelerated stability study, freeze-thaw stability study and centrifugation test were conducted. In addition, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays were conducted to assess its antioxidant effects, whereas tyrosinase inhibitory assay was conducted to determine its anti-tyrosinase activity. The formulated creams appeared light yellowish-brown and homogenous without phase separation. The creams displayed shear-thinning behavior and optimal pH which was ideal for topical application. The creams were stable after being subjected to various stability tests and were shown to have antioxidant and anti-tyrosinase activity. In conclusion, the development of mangosteen-based green cosmeceutical face cream is in line with SDG 3 and 12. It is expected to be used as a safe and effective alternative to synthetic products. [ABSTRACT FROM AUTHOR]
- Published
- 2023
36. Antioxidant Potential of a Novel Polyherbal Formulation: DM-15.
- Author
-
Pei Yi Loh, Rajagopal, Mogana, Selvaraja, Malarvili, Vi Lien Yap, and Lee Fang Tan
- Subjects
- *
NEEM , *CUCUMBERS , *CARDIAC glycosides , *IRON ions , *MOMORDICA charantia , *VITAMIN C , *ONE-way analysis of variance - Abstract
The study aimed to investigate the phytochemical screening and antioxidant potential of a novel polyherbal formulation DM-15, comprising Cucumis sativus L., Momordica charantia and Azadirachta indica. C. sativus, M. charantia and A. indica were blended together and preserved under -80°C for 24 hours. The crystallized DM-15 was obtained from freeze-drying. DM-15 was subjected to phytochemical screening and was tested in vitro antioxidant contents using total phenolics content (TPC) and total flavonoids content (TFC). Its antioxidant activities were also assessed using 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) radical scavenging assays. All determinations of antioxidant activities were performed in triplicates. All data were presented as mean ± SD. Analysis of variance and significant difference among means were tested by one-way ANOVA followed by Tukey's multiple comparison test. Statistical significance was accepted with (P < 0.05), indicating significant difference and 95% of confidence intervals. Statistical analysis was performed using Prism software. Preliminary phytochemical screening showed the presence of alkaloids, flavonoids, saponins, sterols and cardiac glycosides. According to ABTS, the half maximal inhibitory concentration (IC50) values of ascorbic acid (AA), trolox and DM-15 were 1.50 ± 1.15 µg/ml, 0.78 ± 0.06 µg/ml and 92.46 ± 1.78 µg/ml respectively. For DPPH, the IC50 values were 2.57 ± 1.02 µg/ml, 6.85 ± 2.32 µg/ml and 1007.33 ± 4.04 µg/ml for AA, trolox and DM-15 respectively. The FRAP values equivalent to 1 µM FeSO4 of AA, trolox and DM-15 were 52.76 ± 6.46 µg/ml, 53.28 ± 1.28 µg/ml and 22125.07 ± 41.88 µg/ml respectively. TFC of DM-15 was 2.56 ± 0.39 mg of RU/g whereas the TPC value was 10.23 ± 0.20 mg GAE/g. The antioxidant capabilities of the polyherbal DM-15 were ascertained. Knowing the antioxidant properties DM-15, further investigation suggested to investigate its roles in various ailments including cancer and diabetes mellitus. [ABSTRACT FROM AUTHOR]
- Published
- 2023
37. Canarium patentinervium miq. (burseraceae kunth.): a phytochemical and pharmacological study
- Author
-
Rajagopal, Mogana Sundari
- Abstract
Canarium patentinervium Miq. belongs to the family of Burseraceae best known for producing resins of economic, medicinal, and cultural values such as frankincense, myrrh, and copal. This family consists of 18 genera and 700 species of trees. In the Asia-Pacific region, about 20 species of Burseraceae are used to treat haemorrhoids, heal wounds and to treat skin infections. This plant has been used to heal wounds amongst the indigenous people of Malaysia. Furthermore no pharmacological and phytochemical studies have been reported on this species. This study was undertaken to screen the phytochemical and pharmacological aspects of this plant. Qualitative phytochemical properties of the crude extract was determined for the presence of tannins, flavonoids, alkaloids, saponins or sterols. Phytochemical analysis of Canarium patentinervium Miq. revealed presence of tannins and flavonoids in the ethanol extract of leaves and barks. Bioassay guided fractionation led to isolation of eight secondary metabolites by chromatography which were identified by NMR techniques. Two coumarins (scopoletin and scoparone), five phenols (cynaroside, hyperin, (+)-catechin, lioxin and syringic acid) and a norsesquiterpene with cyclohexenone ring (vomifoliol). The latter three compounds were isolated for the first time from the genus Canarium. The plant and the isolated compounds were then subjected to six biological assays comprising of antibacterial, antioxidant, anticancer, anti-inflammatory, anti-acetylcholinesterase and anti-parasitic activities. Infectious diseases remain the leading cause of death worldwide and bacteria have become more resistant to conventional antibiotic and the search for novel antimicrobial agents from medicinal plants has become crucial. Antibacterial test was done using disc diffusion method, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and death kinetic assay with ampicillin as the positive control. The ethanol extract of leaves and the hexane extract of bark displayed remarkable antibacterial activity against both Gram-positive bacteria and Gram-negative bacteria. All isolated compounds tested against S.aureus ATCC 11632 showed bacterial growth inhibition. Scopoletin, scoparone, hyperin, cynaroside and syringic acid had bactericidal effect 200 µg/ml for both Giardia intestinalis and Entamoeba histolytica. Six kinds of major biological effects were evident in the crude and compounds namely, antioxidant, antibacterial, anti-inflammatory, anti-AChE, anti-parasitic, and anticancer all of which were reported for the first time from this plant. Given the aforementioned evidence it is tempting to speculate that Canarium patentinervium Miq. represents an exciting scaffold from which to develop leads for treatment of inflammatory and oxidative stress related diseases.
38. Phytochemical Screening and Evaluation of Antioxidant Interaction in A New Polyherbal Formulation TC-16: When 1+1 ≠ 2.
- Author
-
Lee Fang Tan, Vi Lien Yap, Rajagopal, Mogana, Selvaraja, Malarvili, Mun Yee Leong, and Puay Luan Tan
- Subjects
- *
PHYTOCHEMICALS , *ABSTRACTION reactions , *GINGER , *TURMERIC , *BLACK pepper (Plant) , *FREE radicals , *SAPONINS - Abstract
Free radicals have been associated with the aetiology of many chronic illnesses. Thus, there is an increased need to identify potent antioxidants which can significantly destroy the free radicals. Combination of multiple herbs in polyherbal formulations (PHF) is often associated with greater therapeutic efficacy due to synergism. However, antagonism can occur in natural product mixtures and the resultant antioxidant potential might not always be the additive value of antioxidant properties of each component. The study aimed to evaluate the antioxidant capacity and interaction among the herbs in TC-16, a new PHF comprising Curcuma longa L., Zingiber officinale var. Bentong, Piper nigrum L., Citrofortunella microcarpa (Bunge) Wijnands and Apis dorsata honey. TC-16 was tested for the presence of phytochemicals followed by the determination of phenolic and flavonoid contents. The antioxidant properties of TC-16 and its ingredients were assessed using in vitro antioxidant assays (ABTS, DPPH, FRAP, ORAC, and β-carotene bleaching (BCB) assays). The difference in antioxidant activity and combination index were calculated to study the interactions among the herbs. Alkaloids, flavonoids, steroids, saponins, and glycosides were present in TC-16. TC-16 possessed the highest contents of phenolics (46.14 ± 1.40 mg GAE/g) and flavonoids (132.69 ± 1.43 mg CE/g) after C. longa. Phenolics and flavonoids are well-known antioxidant components that have been reported for their potential health benefits and prevention of diseases. The antioxidant mechanism of TC-16 was mainly by hydrogen atom transfer (HAT), a concerted movement of a proton and an electron in a single kinetic step. Synergism was reported in the antioxidant activity of TC-16 evaluated by ORAC and BCB assays while other assays have demonstrated antagonism. TC-16, a PHF comprising five herbs revealed that HAT is the main mechanism contributing to its antioxidant activity. Free radicals damage is associated with the development of many chronic health disorders. Hence, the antioxidant potential demonstrated by TC-16 could be beneficial in addressing this situation. A future study investigating the interaction of these herbs in combating cancer-related diseases is highly warranted, due to the multifactorial pathogenesis of cancer, which can be addressed by PHF that can act through multiple pathways. [ABSTRACT FROM AUTHOR]
- Published
- 2023
39. Course Satisfaction and Perception of Malaysian Provisionally Registered Pharmacists Towards their Training: A Nationwide Study.
- Author
-
Jing Tian Teo, Mei Qi Hee, Keshavarzi, Fazlollah, and Rajagopal, Mogana
- Subjects
- *
PUBLIC hospitals , *SATISFACTION , *PHARMACISTS , *JOB satisfaction , *DRUGSTORES , *PHARMACEUTICAL industry - Abstract
In Malaysia, all pharmacy graduates are required to undergo a one-year Provisionally Registered Pharmacist (PRP) training in either private or public premises. Due to lack of a comprehensive, nationwide study that covers both public and private of training for the PRP, including government hospital, private hospital, government health clinic, community pharmacy, manufacturing pharmaceutical industry, non-manufacturing pharmaceutical industry, research, and development (academia), a nationwide study is conducted. This study aims to assess the course satisfaction and perception of Malaysian Provisionally Registered Pharmacist towards their training in different settings. A crosssectional nationwide study was conducted among Malaysian PRP who started their PRP training at least 6 months ago and those who finished their PRP training within the past 2 years using a self-administered questionnaire. A total of 255 PRPs participated in the survey. On the basis of the response received, most of the respondents felt that the oneyear training period was sufficient. More than 30% of the respondents from government sectors opined that the logbook is too complicated and some logbook requirements are hard to achieve. Most of the respondents are required to do extended hours except for the pharmaceutical industry. In conclusion, most of the respondents were satisfied with the PRP training in Malaysia. However, there is still some inconsistency of quality in PRP training programs in different settings such as the lack of important facilities on certain premises. The findings of this study indicate some suggestions and factors that affect PRP's job satisfaction. Hence, this can be used as an indicator for further improvement of current PRP training. [ABSTRACT FROM AUTHOR]
- Published
- 2023
40. Therapeutic Effect of a Polyherbal Formulation in Chronic Dysmenorrhea-Induced Mood Disorders.
- Author
-
Ju Jin Tan, Choo Shiuan Por, Kow, Audrey Siew Foong, Rajagopal, Mogana, and Ming Tatt Lee
- Subjects
- *
AFFECTIVE disorders , *TREATMENT effectiveness , *LABORATORY mice , *OXYTOCIN , *ANXIETY , *MENSTRUATION - Abstract
Dysmenorrhea is often being neglected among women with the mindset that it is not life-threatening, treatment is sought only when present signs/symptoms. Previous studies have proven that women with dysmenorrhea are more susceptible to depression and anxiety as a result of menstrual pain. This research aims to study the potential therapeutic effect of MM-15 polyherbal formulation on chronic dysmenorrhea-associated mood disorders. Adult female ICR mice were employed in this study. Sixty non-pregnant mice were randomly grouped into six groups: estrogen + normal saline group; estrogen + oxytocin group; estrogen + oxytocin + purified water group; estrogen + oxytocin + MM-15 group (50mg/kg p.o.); estrogen + oxytocin + MM-15 group (100mg/kg p.o.); estrogen + oxytocin + MM-15 group (200mg/kg p.o.). Open field test (OFT), social interaction test (SIT) and tail suspension test (TST) were employed to measure the effect of MM-15 formulation on chronic dysmenorrhea-induced mood disorders. From the analyzed result, high dose of MM-15 formulation (200mg/kg, p.o.) increased the total distance travelled in OFT which indicated significantly reduction in anxiety-like response. In TST, the same dose of MM-15 formulation significantly showed potential antidepressant response by reducing immobility time. In SIT, all dose of MM-15 formulation does not improve social-withdrawal behavior in mice with chronic dysmenorrhea. Overall, MM-15 polyherbal formulation has a significant result in reducing chronic dysmenorrhea-induced mood disorders in mice, including depressive and anxiety-like behaviours. [ABSTRACT FROM AUTHOR]
- Published
- 2023
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.