1. Novel Conformal Skin Patch with Embedded Thin-Film Electrodes for Early Detection of Extravasation
- Author
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Ming-Yuan Cheng, Swee Kim Tan, Ramona Damalerio, Choon Looi Bong, and Ruiqi Lim
- Subjects
Leak ,Early detection ,TP1-1185 ,02 engineering and technology ,010402 general chemistry ,medical ,01 natural sciences ,Biochemistry ,wearable ,Analytical Chemistry ,sensor ,In vivo ,noninvasive ,medicine ,Animals ,Humans ,Electrical and Electronic Engineering ,Vein ,Electrodes ,Instrumentation ,business.industry ,Communication ,Chemical technology ,021001 nanoscience & nanotechnology ,Atomic and Molecular Physics, and Optics ,Extravasation ,0104 chemical sciences ,Skin patch ,Early Diagnosis ,medicine.anatomical_structure ,extravasations ,Thin film electrode ,Gold ,0210 nano-technology ,business ,Extravasation of Diagnostic and Therapeutic Materials ,Subcutaneous tissue ,Biomedical engineering - Abstract
Extravasation is a complication of intravenous (IV) cannulation in which vesicant drugs leak from a vein into the surrounding subcutaneous tissue. The severity of extravasation depends on the type, concentration, and volume of drugs that accumulate in the subcutaneous tissue. Rapid detection of extravasation can facilitate prompt medical intervention, minimizing tissue damage, and preventing adverse events. In this study, we present two portable sensor patches, namely gold- and carbon-based sensing patches, for early detection of extravasation. The gold-based sensor patch detected extravasated fluid of volume as low as 2 mL in in vivo animal models and human clinical trials; the patch exhibited a resistance change of 41%. The carbon-based sensor patch exhibited a resistance change of 51% for 2 mL of extravasated fluid, and fabrication throughput and cost-effectiveness are superior for this patch compared with the gold-based sensing patch.
- Published
- 2021