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Objectives: Circular RNA&#95;0003489 (Circ&#95;0003489) promotes multiple myeloma (MM) progression and bortezomib resistance in MM cells, while its potential as a biomarker in newly diagnosed MM (NDMM) patients is unclear. Thus, this study aimed to investigate the association of circ&#95;0003489 expression with treatment response and survival in NDMM patients who received bortezomib-based induction therapy., Methods: Bone marrow (BM) specimens from 85 NDMM patients at diagnosis or before treatment and from 15 donor controls during BM examination were retrieved in this retrospective study. Circ&#95;0003489 derived from BM plasma cells was detected by reverse transcription-quantitative polymerase chain reaction and cut by quartile and median for further analysis., Results: Circ&#95;0003489 expression was increased in NDMM patients versus donor controls ( P  < 0.001). Circ&#95;0003489 quartile was positively correlated with BM plasma cells ( P  = 0.040), international staging system (ISS) stage ( P  = 0.007), the revision of ISS stage ( P  = 0.003), beta-2-microglobulin ( P  = 0.011), and lactate dehydrogenase ( P  = 0.042) in NDMM patients. Increased circ&#95;0003489 quartile was linked with a lower possibility of achieving complete response ( P  = 0.020) and partial response or better ( P  = 0.041) in NDMM patients. Elevated circ&#95;0003489 expression cut by quartile ( P  = 0.020) and cut by median ( P  = 0.006) were linked with decreased progression-free survival (PFS) in NDMM patients. Increased circ&#95;0003489 expression cut by median was associated with shortened overall survival (OS) in NDMM patients ( P  = 0.038). Meanwhile, higher circ&#95;0003489 quartile independently forecasted poorer PFS (hazard ratio = 1.342, P  = 0.045), but not OS in NDMM patients., Conclusion: Circ&#95;0003489 expression is increased and reflects unfavorable treatment response and survival in NDMM patients who receive bortezomib-based induction therapy.