1. Impaired Coronary Flow Reserve as a Marker of Microvascular Dysfunction to Predict Long-Term Cardiovascular Outcomes, Acute Coronary Syndrome and the Development of Heart Failure
- Author
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Kumiko Maeda, Takahiko Kawarabayashi, Reiko Miyahana, Junichi Yoshikawa, Kenichiro Otsuka, Kenei Shimada, Hiroyuki Watanabe, Chinami Miyazaki, Minoru Yoshiyama, Shota Fukuda, and Koki Nakanishi
- Subjects
Male ,medicine.medical_specialty ,Acute coronary syndrome ,Doppler echocardiography ,Coronary artery disease ,Predictive Value of Tests ,Risk Factors ,Coronary Circulation ,Internal medicine ,medicine ,Humans ,Acute Coronary Syndrome ,Risk factor ,Aged ,Aged, 80 and over ,Heart Failure ,medicine.diagnostic_test ,business.industry ,Microcirculation ,Area under the curve ,Coronary flow reserve ,General Medicine ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Echocardiography ,Heart failure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
Background: In the absence of obstructive coronary narrowing, impaired coronary flow reserve (CFR) represents coronary microvascular dysfunction. Transthoracic Doppler echocardiography (TTDE) allows non-invasive measurement of CFR in the left anterior descending (LAD) artery. This study aimed to assess the prognostic value of TTDE-derived CFR (as a marker of microvascular function) in predicting long-term cardiovascular events, acute coronary syndrome (ACS) events, and the development of heart failure (HF). Methods and Results: This study consisted of 272 patients with coronary artery disease not involving obstructive narrowing (≥50%) in the LAD. Patients underwent TTDE examination for CFR measurement in the LAD. During the follow-up period of 4.0±1.9 years, 32 patients (12%) had cardiovascular events. Cox proportional hazard analysis identified lower CFR as an independent risk factor of cardiovascular events (P
- Published
- 2012
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