5 results on '"Ricardo C. -H. del Rosario"'
Search Results
2. Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection
- Author
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Ricardo C. H. del Rosario, Jeremie Poschmann, Carey Lim, Catherine Y. Cheng, Pavanish Kumar, Catherine Riou, Seow Theng Ong, Sherif Gerges, Hajira Shreen Hajan, Dilip Kumar, Mardiana Marzuki, Xiaohua Lu, Andrea Lee, Giovani Claresta Wijaya, Nirmala Arul Rayan, Zhong Zhuang, Elsa Du Bruyn, Cynthia Bin Eng Chee, Bernett Lee, Josephine Lum, Francesca Zolezzi, Michael Poidinger, Olaf Rotzschke, Chiea Chuen Khor, Robert J. Wilkinson, Yee T. Wang, George K Chandy, Gennaro De Libero, Amit Singhal, Shyam Prabhakar, and Wellcome Trust
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EXPRESSION ,Adult ,Male ,Microbiology (medical) ,THP-1 Cells ,Quantitative Trait Loci ,Immunology ,VARIANTS ,Proof of Concept Study ,Applied Microbiology and Biotechnology ,Microbiology ,Monocytes ,Cohort Studies ,Histones ,South Africa ,Young Adult ,1108 Medical Microbiology ,Genetics ,Humans ,Tuberculosis ,Longitudinal Studies ,CHROMATIN STATES ,SIGNATURES ,Genetic Association Studies ,Singapore ,Science & Technology ,IDENTIFICATION ,Acetylation ,Mycobacterium tuberculosis ,Cell Biology ,GENE ,Chromatin ,APOPTOSIS ,K+ CHANNEL ,AUTOPHAGY ,Female ,MACROPHAGE ,Life Sciences & Biomedicine ,Granulocytes ,0605 Microbiology - Abstract
Host cell chromatin changes are thought to play an important role in the pathogenesis of infectious diseases. Here we describe a histone acetylome-wide association study (HAWAS) of an infectious disease, on the basis of genome-wide H3K27 acetylation profiling of peripheral blood granulocytes and monocytes from persons with active Mycobacterium tuberculosis (Mtb) infection and healthy controls. We detected >2,000 differentially acetylated loci in either cell type in a Singapore Chinese discovery cohort (n = 46), which were validated in a subsequent multi-ethnic Singapore cohort (n = 29), as well as a longitudinal cohort from South Africa (n = 26), thus demonstrating that HAWAS can be independently corroborated. Acetylation changes were correlated with differential gene expression. Differential acetylation was enriched near potassium channel genes, including KCNJ15, which modulates apoptosis and promotes Mtb clearance in vitro. We performed histone acetylation quantitative trait locus (haQTL) analysis on the dataset and identified 69 candidate causal variants for immune phenotypes among granulocyte haQTLs and 83 among monocyte haQTLs. Our study provides proof-of-principle for HAWAS to infer mechanisms of host response to pathogens.
- Published
- 2022
3. Author Correction: Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection
- Author
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Ricardo C. H. del Rosario, Jeremie Poschmann, Carey Lim, Catherine Y. Cheng, Pavanish Kumar, Catherine Riou, Seow Theng Ong, Sherif Gerges, Hajira Shreen Hajan, Dilip Kumar, Mardiana Marzuki, Xiaohua Lu, Andrea Lee, Giovani Claresta Wijaya, Nirmala Arul Rayan, Zhong Zhuang, Elsa Du Bruyn, Cynthia Bin Eng Chee, Bernett Lee, Josephine Lum, Francesca Zolezzi, Michael Poidinger, Olaf Rotzschke, Chiea Chuen Khor, Robert J. Wilkinson, Yee T. Wang, George K Chandy, Gennaro De Libero, Amit Singhal, Shyam Prabhakar, KERANDEL-DION, Céline, Genome Institute of Singapore (GIS), Stanley Center for Psychiatric Research [Cambridge, MA, USA], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Harvard Medical School [Boston] (HMS), Team 6 : Impact of acute inflammation on host pathogen interactions and lung homeostasis (U1064 Inserm - CR2TI), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Singapore Immunology Network (SIgN), Biomedical Sciences Institute (BMSI), University of Cape Town, Nanyang Technological University [Singapour], Massachusetts General Hospital [Boston], Tan Tock Seng Hospital, Imperial College London, The Francis Crick Institute [London], University of Basel (Unibas), Data Storage Institute - A*STAR, and Agency for science, technology and research [Singapore] (A*STAR)
- Subjects
Microbiology (medical) ,[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,Immunology ,Genetics ,Cell Biology ,Applied Microbiology and Biotechnology ,Microbiology - Abstract
International audience; No abstract available
- Published
- 2022
4. Model Construction and Analysis of Respiration in Halobacterium salinarum.
- Author
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Cherryl O Talaue, Ricardo C H del Rosario, Friedhelm Pfeiffer, Eduardo R Mendoza, and Dieter Oesterhelt
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Medicine ,Science - Abstract
The archaeon Halobacterium salinarum can produce energy using three different processes, namely photosynthesis, oxidative phosphorylation and fermentation of arginine, and is thus a model organism in bioenergetics. Compared to its bacteriorhodopsin-driven photosynthesis, less attention has been devoted to modeling its respiratory pathway. We created a system of ordinary differential equations that models its oxidative phosphorylation. The model consists of the electron transport chain, the ATP synthase, the potassium uniport and the sodium-proton antiport. By fitting the model parameters to experimental data, we show that the model can explain data on proton motive force generation, ATP production, and the charge balancing of ions between the sodium-proton antiporter and the potassium uniport. We performed sensitivity analysis of the model parameters to determine how the model will respond to perturbations in parameter values. The model and the parameters we derived provide a resource that can be used for analytical studies of the bioenergetics of H. salinarum.
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- 2016
- Full Text
- View/download PDF
5. Multiplex precise base editing in cynomolgus monkeys
- Author
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Wenhui Zhang, Tomomi Aida, Ricardo C. H. del Rosario, Jonathan J. Wilde, Chenhui Ding, Xiaohui Zhang, Zulqurain Baloch, Yan Huang, Yu Tang, Duanduan Li, Hongyu Lu, Yang Zhou, Minqing Jiang, Dongdong Xu, Zhihao Fang, Zhanhong Zheng, Qunshan Huang, Guoping Feng, and Shihua Yang
- Subjects
Science - Abstract
Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey embryos with high specificity.
- Published
- 2020
- Full Text
- View/download PDF
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