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11 results on '"Ritter, Mathilde"'

1. Establishing standardized immune phenotyping of metastatic melanoma by digital pathology

Author

Sobottka, Bettina, Nowak, Marta, Frei, Anja Laura, Haberecker, Martina, Merki, Samuel, Levesque, Mitchell P., Dummer, Reinhard, Moch, Holger, Koelzer, Viktor Hendrik, Aebersold, Rudolf, Ak, Melike, Al-Quaddoomi, Faisal S., Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Beerenwinkel, Niko, Beisel, Christian, Bernasconi, Lara, Bertolini, Anne, Bodenmiller, Bernd, Bonilla, Ximena, Casanova, Ruben, Chevrier, Stéphane, Chicherova, Natalia, D'Costa, Maya, Danenberg, Esther, Davidson, Natalie, Drăganmoch, Monica-Andreea, Engler, Stefanie, Erkens, Martin, Eschbach, Katja, Esposito, Cinzia, Fedier, André, Ferreira, Pedro, Ficek, Joanna, Frey, Bruno, Goetze, Sandra, Grob, Linda, Gut, Gabriele, Günther, Detlef, Haeuptle, Pirmin, Heinzelmann-Schwarz, Viola, Herter, Sylvia, Holtackers, Rene, Huesser, Tamara, Irmisch, Anja, Jacob, Francis, Jacobs, Andrea, Jaeger, Tim M., Jahn, Katharina, James, Alva R., Jermann, Philip M., Kahles, André, Kahraman, Abdullah, Kuebler, Werner, Kuipers, Jack, Kunze, Christian P., Kurzeder, Christian, Lehmann, Kjong-Van, Lugert, Sebastian, Maass, Gerd, Manz, Markus G., Markolin, Philipp, Mena, Julien, Menzel, Ulrike, Metzler, Julian M., Miglino, Nicola, Milani, Emanuela S., Muenst, Simone, Murri, Riccardo, Ng, Charlotte K.Y., Nicolet, Stefan, Pedrioli, Patrick G.A., Pelkmans, Lucas, Piscuoglio, Salvatore, Prummer, Michael, Ritter, Mathilde, Rommel, Christian, Rosano-González, María L., Rätsch, Gunnar, Santacroce, Natascha, del Castillo, Jacobo Sarabia, Schlenker, Ramona, Schwalie, Petra C., Schwan, Severin, Schär, Tobias, Senti, Gabriela, Singer, Franziska, Sivapatham, Sujana, Snijder, Berend, Sreedharan, Vipin T., Stark, Stefan, Stekhoven, Daniel J., Theocharides, Alexandre P.A., Thomas, Tinu M., Tolnay, Markus, Tosevski, Vinko, Toussaint, Nora C., Tuncel, Mustafa A., Tusup, Marina, Van Drogen, Audrey, Vetter, Marcus, Vlajnic, Tatjana, Weber, Sandra, Weber, Walter P., Wegmann, Rebekka, Weller, Michael, Wendt, Fabian, Wey, Norbert, Wicki, Andreas, Wildschut, Mattheus HE, Wollscheid, Bernd, Yu, Shuqing, Ziegler, Johanna, Zimmermann, Marc, Zoche, Martin, and Zuend, Gregor

Published
2021
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2. Detection of clustered circulating tumour cells in early breast cancer

Author

Krol, Ilona, Schwab, Fabienne D., Carbone, Roberta, Ritter, Mathilde, Picocci, Sabrina, De Marni, Marzia L., Stepien, Grazyna, Franchi, Gian M., Zanardi, Andrea, Rissoglio, Marco D., Covelli, Alfredo, Guidi, Guido, Scarinci, Daniele, Castro-Giner, Francesc, Mazzarella, Luca, Doglioni, Claudio, Borghi, Francesca, Milani, Paolo, Kurzeder, Christian, Weber, Walter P., and Aceto, Nicola

Published
2021
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3. ASO Visual Abstract : Retrospective Multicenter Analysis Comparing Conventional with Oncoplastic Breast-Conserving Surgery: Oncological and Surgical Outcomes in Women with High-Risk Breast Cancer from the OPBC-01/iTOP2 Study

Author

Fitzal, Florian, Bolliger, Michael, Dunkler, Daniela, Geroldinger, Angelika, Gambone, Luca, Heil, Jörg, Riedel, Fabian, de Boniface, Jana, André, Camilla, Matrai, Zoltan, Pukancsik, David, Paulinelli, Regis R., Ostapenko, Valerijus, Burneckis, Arvydas, Ostapenko, Andrej, Ostapenko, Edvin, Meani, Francesco, Harder, Yves, Bonollo, Marta, Alberti, Andrea S. M., Tausch, Christoph, Papassotiropoulos, Bärbel, Helfgott, Ruth, Heck, Dietmar, Fehrer, Hans-Jörg, Acko, Markus, Schrenk, Peter, Trapp, Elisabeth, Gunda, Pristauz-Telsnigg, Clara, Paliczek, Montagna, Giacomo, Ritter, Mathilde, Blohmer, Jens-Uwe, Steffen, Sander, Romics, Laszlo, Morrow, Elizabeth, Lorenz, Katharina, Fehr, Mathias, Weber, Walter Paul, Fitzal, Florian, Bolliger, Michael, Dunkler, Daniela, Geroldinger, Angelika, Gambone, Luca, Heil, Jörg, Riedel, Fabian, de Boniface, Jana, André, Camilla, Matrai, Zoltan, Pukancsik, David, Paulinelli, Regis R., Ostapenko, Valerijus, Burneckis, Arvydas, Ostapenko, Andrej, Ostapenko, Edvin, Meani, Francesco, Harder, Yves, Bonollo, Marta, Alberti, Andrea S. M., Tausch, Christoph, Papassotiropoulos, Bärbel, Helfgott, Ruth, Heck, Dietmar, Fehrer, Hans-Jörg, Acko, Markus, Schrenk, Peter, Trapp, Elisabeth, Gunda, Pristauz-Telsnigg, Clara, Paliczek, Montagna, Giacomo, Ritter, Mathilde, Blohmer, Jens-Uwe, Steffen, Sander, Romics, Laszlo, Morrow, Elizabeth, Lorenz, Katharina, Fehr, Mathias, and Weber, Walter Paul

Published
2022
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4. Retrospective, Multicenter Analysis Comparing Conventional with Oncoplastic Breast Conserving Surgery : Oncological and Surgical Outcomes in Women with High-Risk Breast Cancer from the OPBC-01/iTOP2 Study

Author

Fitzal, Florian, Bolliger, Michael, Dunkler, Daniela, Geroldinger, Angelika, Gambone, Luca, Heil, Joerg, Riedel, Fabian, de Boniface, Jana, André, Camilla, Matrai, Zoltan, Pukancsik, David, Paulinelli, Regis R., Ostapenko, Valerijus, Burneckis, Arvydas, Ostapenko, Andrej, Ostapenko, Edvin, Meani, Francesco, Harder, Yves, Bonollo, Marta, Alberti, Andrea S. M., Tausch, Christoph, Papassotiropoulos, Baerbel, Helfgott, Ruth, Heck, Dietmar, Fehrer, Hans-Joerg, Acko, Markus, Schrenk, Peter, Trapp, Elisabeth K., Gunda, Pristauz-Telsnigg, Clara, Paliczek, Montagna, Giacomo, Ritter, Mathilde, Blohmer, Jens-Uwe, Steffen, Sander, Romics, Laszlo, Morrow, Elizabeth, Lorenz, Katharina, Fehr, Mathias, Weber, Walter Paul, Fitzal, Florian, Bolliger, Michael, Dunkler, Daniela, Geroldinger, Angelika, Gambone, Luca, Heil, Joerg, Riedel, Fabian, de Boniface, Jana, André, Camilla, Matrai, Zoltan, Pukancsik, David, Paulinelli, Regis R., Ostapenko, Valerijus, Burneckis, Arvydas, Ostapenko, Andrej, Ostapenko, Edvin, Meani, Francesco, Harder, Yves, Bonollo, Marta, Alberti, Andrea S. M., Tausch, Christoph, Papassotiropoulos, Baerbel, Helfgott, Ruth, Heck, Dietmar, Fehrer, Hans-Joerg, Acko, Markus, Schrenk, Peter, Trapp, Elisabeth K., Gunda, Pristauz-Telsnigg, Clara, Paliczek, Montagna, Giacomo, Ritter, Mathilde, Blohmer, Jens-Uwe, Steffen, Sander, Romics, Laszlo, Morrow, Elizabeth, Lorenz, Katharina, Fehr, Mathias, and Weber, Walter Paul

Abstract

Introduction Recent data suggest that margins >= 2 mm after breast-conserving surgery may improve local control in invasive breast cancer (BC). By allowing large resection volumes, oncoplastic breast-conserving surgery (OBCII; Clough level II/Tubingen 5-6) may achieve better local control than conventional breast conserving surgery (BCS; Tubingen 1-2) or oncoplastic breast conservation with low resection volumes (OBCI; Clough level I/Tubingen 3-4). Methods Data from consecutive high-risk BC patients treated in 15 centers from the Oncoplastic Breast Consortium (OPBC) network, between January 2010 and December 2013, were retrospectively reviewed. Results A total of 3,177 women were included, 30% of whom were treated with OBC (OBCI n = 663; OBCII n = 297). The BCS/OBCI group had significantly smaller tumors and smaller resection margins compared with OBCII (pT1: 50% vs. 37%, p = 0.002; proportion with margin <1 mm: 17% vs. 6%, p < 0.001). There were significantly more re-excisions due to R1 ("ink on tumor") in the BCS/OBCI compared with the OBCII group (11% vs. 7%, p = 0.049). Univariate and multivariable regression analysis adjusted for tumor biology, tumor size, radiotherapy, and systemic treatment demonstrated no differences in local, regional, or distant recurrence-free or overall survival between the two groups. Conclusions Large resection volumes in oncoplastic surgery increases the distance from cancer cells to the margin of the specimen and reduces reexcision rates significantly. With OBCII larger tumors are resected with similar local, regional and distant recurrence-free as well as overall survival rates as BCS/OBCI.

Published
2022
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5. Bisfenol A, um dos fatores envolvidos na etiologia da Hipomineralização Incisivo-Molar? Uma revisão sistemática

Author

Ritter, Mathilde Brigitte Jacqueline and BRAZ, MARIA DO PRANTO VALENTE

Subjects
Molar Incisor Hypomineralization, Bisphenol A, Amelogenesis, Perinatal factor(s), Dental Enamel Hypoplasia, Endocrine Disruptors
Abstract

A hipomineralização incisivo-molar (MIH) é uma patologia caracterizada pela diminuição da mineralização dos primeiros molares permanentes frequentemente associada aos incisivos permanentes. Clinicamente, apresenta como opacidades demarcadas do esmalte (mole e poroso) de cor diferente nos dentes afetados, que ocasionalmente sofrem uma quebra pós eruptiva. Embora a etiologia desta doença, que afeta cerca de 18% das crianças, seja incerta, existem algumas dúvidas sobre o bisfenol A (BPA). Esta molécula exibe efeitos que mimetizam o estrogênio (E2), poderá ter um papel na perturbação da amelogénese. O objetivo deste estudo consiste em avaliar o conhecimento que a literatura científica atual nos traz sobre a possível influência do BPA na etiologia da MIH. Formulou-se uma questão segundo a estratégica PICOS e como orientação o PRISMA. Uma pesquisa bibliográfica foi realizada na base de dados: PubMed, Cochrane Library e ScienceDirect utilizando combinações das palavras-chave e abrangendo artigos entre 2010 e 2021 de idioma inglês. Mais de 83% da população apresenta concentração superior ao LOD nas suas urinas. A mediana das concentrações de BPA observadas é inferior à TDI. Correlação com: idade, inter-familiar, sócio-económico e localização. A hipomineralização do esmalte por BPA deve-se à perturbação de um pequeno número de genes que controlam a qualidade do esmalte, por EMPs, proteases e reguladores de homeostasia. A contaminação por BPA é principalmente oral. A exposição ao BPA durante o período crítico da mineralização dentária, enfraquece o esmalte, tornando-o mais propenso a gerar defeitos de mineralização frequentes, tais como MIH. Palavras-chave: Hipoplasia do Esmalte Dentário, Hipomineralização Incisivo-Molar, Amelogénese, Desreguladores Endócrinos, Bisfenol A, Factor(es) Perinatal.

Published
2021

6. Breast conservation and axillary management after primary systemic therapy in patients with early-stage breast cancer: the Lucerne toolbox

Author

Dubsky, Peter, Pinker, Katja, Cardoso, Fatima, Montagna, Giacomo, Ritter, Mathilde, Denkert, Carsten, Rubio, Isabel Teresa, de Azambuja, Evandro, Curigliano, Giuseppe, Gentilini, Oreste, Gnant, Michael, Günthert, Andreas, Hauser, Nik, Heil, Jörg, Knauer, Michael, Knotek-Roggenbauerc, Mona, Knox, Susan, Kovacs, Tibor, Kuerer, Henry, Loibl, Sibylle, Mannhart, Meinrad, Meattini, Icro, Penault-Llorca, Frederique, Radosevic-Robin, Nina, Sager, Patrizia, Španić, Tanja, Steyerova, Petra, Tausch, Christoph, Peeters, Marie Jeanne M.J.T.F.D.V., Weber, Walter Paul, Cardoso, Maria João, Poortmans, Philipp, Dubsky, Peter, Pinker, Katja, Cardoso, Fatima, Montagna, Giacomo, Ritter, Mathilde, Denkert, Carsten, Rubio, Isabel Teresa, de Azambuja, Evandro, Curigliano, Giuseppe, Gentilini, Oreste, Gnant, Michael, Günthert, Andreas, Hauser, Nik, Heil, Jörg, Knauer, Michael, Knotek-Roggenbauerc, Mona, Knox, Susan, Kovacs, Tibor, Kuerer, Henry, Loibl, Sibylle, Mannhart, Meinrad, Meattini, Icro, Penault-Llorca, Frederique, Radosevic-Robin, Nina, Sager, Patrizia, Španić, Tanja, Steyerova, Petra, Tausch, Christoph, Peeters, Marie Jeanne M.J.T.F.D.V., Weber, Walter Paul, Cardoso, Maria João, and Poortmans, Philipp

Abstract

Primary systemic therapy is increasingly used in the treatment of patients with early-stage breast cancer, but few guidelines specifically address optimal locoregional therapies. Therefore, we established an international consortium to discuss clinical evidence and to provide expert advice on technical management of patients with early-stage breast cancer. The steering committee prepared six working packages to address all major clinical questions from diagnosis to surgery. During a consensus meeting that included members from European scientific oncology societies, clinical trial groups, and patient advocates, statements were discussed and voted on. A consensus was reached in 42% of statements, a majority in 38%, and no decision in 21%. Based on these findings, the panel developed clinical guidance recommendations and a toolbox to overcome many clinical and technical requirements associated with the diagnosis, response assessment, surgical planning, and surgery of patients with early-stage breast cancer. This guidance could convince clinicians and patients of the major clinical advancements purported by primary systemic therapy, the use of less extensive and more targeted surgery to improve the lives of patients with breast cancer., SCOPUS: re.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2021

7. SCIM: universal single-cell matching with unpaired feature sets

Author

Stark, Stefan G, Ficek, Joanna, Locatello, Francesco, Bonilla, Ximena, Chevrier, Stéphane, Singer, Franziska, Aebersold, Rudolf, Al-Quaddoomi, Faisal S, Albinus, Jonas, Alborelli, Ilaria, Andani, Sonali, Attinger, Per-Olof, Bacac, Marina, Baumhoer, Daniel, Beck-Schimmer, Beatrice, Beerenwinkel, Niko, Beisel, Christian, Bernasconi, Lara, Bertolini, Anne, Bodenmiller, Bernd, Casanova, Ruben, Chicherova, Natalia, D'Costa, Maya, Danenberg, Esther, Davidson, Natalie, gan, Monica-Andreea Dră, Dummer, Reinhard, Engler, Stefanie, Erkens, Martin, Eschbach, Katja, Esposito, Cinzia, Fedier, André, Ferreira, Pedro, Frei, Anja L, Frey, Bruno, Goetze, Sandra, Grob, Linda, Gut, Gabriele, Günther, Detlef, Haberecker, Martina, Haeuptle, Pirmin, Heinzelmann-Schwarz, Viola, Herter, Sylvia, Holtackers, Rene, Huesser, Tamara, Irmisch, Anja, Jacob, Francis, Jacobs, Andrea, Jaeger, Tim M, Jahn, Katharina, James, Alva R, Jermann, Philip M, Kahles, André, Kahraman, Abdullah, Koelzer, Viktor H, Kuebler, Werner, Kuipers, Jack, Kunze, Christian P, Kurzeder, Christian, Lehmann, Kjong-Van, Levesque, Mitchell, Lugert, Sebastian, Maass, Gerd, Manz, Markus, Markolin, Philipp, Mena, Julien, Menzel, Ulrike, Metzler, Julian M, Miglino, Nicola, Milani, Emanuela S, Moch, Holger, Muenst, Simone, Murri, Riccardo, Ng, Charlotte KY, Nicolet, Stefan, Nowak, Marta, Pedrioli, Patrick GA, Pelkmans, Lucas, Piscuoglio, Salvatore, Prummer, Michael, Ritter, Mathilde, Rommel, Christian, Rosano-González, María L, Rätsch, Gunnar, Santacroce, Natascha, Castillo, Jacobo Sarabia del, Schlenker, Ramona, Schwalie, Petra C, Schwan, Severin, Schär, Tobias, Senti, Gabriela, Sivapatham, Sujana, Snijder, Berend, Sobottka, Bettina, Sreedharan, Vipin T, Stark, Stefan, Stekhoven, Daniel J, Theocharides, Alexandre PA, Thomas, Tinu M, Tolnay, Markus, Tosevski, Vinko, Toussaint, Nora C, Tuncel, Mustafa A, Tusup, Marina, Drogen, Audrey Van, Vetter, Marcus, Vlajnic, Tatjana, Weber, Sandra, Weber, Walter P, Wegmann, Rebekka, Weller, Michael, Wendt, Fabian, Wey, Norbert, Wicki, Andreas, Wollscheid, Bernd, Yu, Shuqing, Ziegler, Johanna, Zimmermann, Marc, Zoche, Martin, Zuend, Gregor, and University of Zurich

Subjects
Statistics and Probability, 1303 Biochemistry, AcademicSubjects/SCI01060, Computer science, 610 Medicine & health, computer.software_genre, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Text mining, 1312 Molecular Biology, 1706 Computer Science Applications, Humans, Profiling (information science), 2613 Statistics and Probability, Molecular Biology, 030304 developmental biology, Data, 0303 health sciences, Sequence Analysis, RNA, business.industry, Gene Expression Profiling, Autoencoder, Computer Science Applications, Computational Mathematics, Computational Theory and Mathematics, 10032 Clinic for Oncology and Hematology, Bipartite graph, Data mining, Single-Cell Analysis, business, computer, 2605 Computational Mathematics, Algorithms, Software, 030217 neurology & neurosurgery, Data integration, 1703 Computational Theory and Mathematics
Abstract

Motivation: Recent technological advances have led to an increase in the production and availability of single-cell data. The ability to integrate a set of multi-technology measurements would allow the identification of biologically or clinically meaningful observations through the unification of the perspectives afforded by each technology. In most cases, however, profiling technologies consume the used cells and thus pairwise correspondences between datasets are lost. Due to the sheer size single-cell datasets can acquire, scalable algorithms that are able to universally match single-cell measurements carried out in one cell to its corresponding sibling in another technology are needed. Results: We propose Single-Cell data Integration via Matching (SCIM), a scalable approach to recover such correspondences in two or more technologies. SCIM assumes that cells share a common (low-dimensional) underlying structure and that the underlying cell distribution is approximately constant across technologies. It constructs a technology-invariant latent space using an autoencoder framework with an adversarial objective. Multi-modal datasets are integrated by pairing cells across technologies using a bipartite matching scheme that operates on the low-dimensional latent representations. We evaluate SCIM on a simulated cellular branching process and show that the cell-to-cell matches derived by SCIM reflect the same pseudotime on the simulated dataset. Moreover, we apply our method to two real-world scenarios, a melanoma tumor sample and a human bone marrow sample, where we pair cells from a scRNA dataset to their sibling cells in a CyTOF dataset achieving 90% and 78% cell-matching accuracy for each one of the samples, respectively., Bioinformatics, 36 (S2), ISSN:1367-4803, ISSN:1460-2059

Published
2020

8. The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support

Author

Irmisch, Anja, primary, Bonilla, Ximena, additional, Chevrier, Stéphane, additional, Lehmann, Kjong-Van, additional, Singer, Franziska, additional, Toussaint, Nora C., additional, Esposito, Cinzia, additional, Mena, Julien, additional, Milani, Emanuela S., additional, Casanova, Ruben, additional, Stekhoven, Daniel J., additional, Wegmann, Rebekka, additional, Jacob, Francis, additional, Sobottka, Bettina, additional, Goetze, Sandra, additional, Kuipers, Jack, additional, Sarabia del Castillo, Jacobo, additional, Prummer, Michael, additional, Tuncel, Mustafa A., additional, Menzel, Ulrike, additional, Jacobs, Andrea, additional, Engler, Stefanie, additional, Sivapatham, Sujana, additional, Frei, Anja L., additional, Gut, Gabriele, additional, Ficek, Joanna, additional, Miglino, Nicola, additional, Aebersold, Rudolf, additional, Bacac, Marina, additional, Beerenwinkel, Niko, additional, Beisel, Christian, additional, Bodenmiller, Bernd, additional, Dummer, Reinhard, additional, Heinzelmann-Schwarz, Viola, additional, Koelzer, Viktor H., additional, Manz, Markus G., additional, Moch, Holger, additional, Pelkmans, Lucas, additional, Snijder, Berend, additional, Theocharides, Alexandre P.A., additional, Tolnay, Markus, additional, Wicki, Andreas, additional, Wollscheid, Bernd, additional, Rätsch, Gunnar, additional, Levesque, Mitchell P., additional, Ak, Melike, additional, Al-Quaddoomi, Faisal S., additional, Albinus, Jonas, additional, Alborelli, Ilaria, additional, Andani, Sonali, additional, Attinger, Per-Olof, additional, Baumhoer, Daniel, additional, Beck-Schimmer, Beatrice, additional, Bernasconi, Lara, additional, Bertolini, Anne, additional, Chicherova, Natalia, additional, D'Costa, Maya, additional, Danenberg, Esther, additional, Davidson, Natalie, additional, Drăgan, Monica-Andreea, additional, Erkens, Martin, additional, Eschbach, Katja, additional, Fedier, André, additional, Ferreira, Pedro, additional, Frey, Bruno, additional, Grob, Linda, additional, Günther, Detlef, additional, Haberecker, Martina, additional, Haeuptle, Pirmin, additional, Herter, Sylvia, additional, Holtackers, Rene, additional, Huesser, Tamara, additional, Jaeger, Tim M., additional, Jahn, Katharina, additional, James, Alva R., additional, Jermann, Philip M., additional, Kahles, André, additional, Kahraman, Abdullah, additional, Kuebler, Werner, additional, Kunze, Christian P., additional, Kurzeder, Christian, additional, Lugert, Sebastian, additional, Maass, Gerd, additional, Markolin, Philipp, additional, Metzler, Julian M., additional, Muenst, Simone, additional, Murri, Riccardo, additional, Ng, Charlotte K.Y., additional, Nicolet, Stefan, additional, Nowak, Marta, additional, Pedrioli, Patrick G.A., additional, Piscuoglio, Salvatore, additional, Ritter, Mathilde, additional, Rommel, Christian, additional, Rosano-González, María L., additional, Santacroce, Natascha, additional, Schlenker, Ramona, additional, Schwalie, Petra C., additional, Schwan, Severin, additional, Schär, Tobias, additional, Senti, Gabriela, additional, Sreedharan, Vipin T., additional, Stark, Stefan, additional, Thomas, Tinu M., additional, Tosevski, Vinko, additional, Tusup, Marina, additional, Van Drogen, Audrey, additional, Vetter, Marcus, additional, Vlajnic, Tatjana, additional, Weber, Sandra, additional, Weber, Walter P., additional, Weller, Michael, additional, Wendt, Fabian, additional, Wey, Norbert, additional, Wildschut, Mattheus H.E., additional, Yu, Shuqing, additional, Ziegler, Johanna, additional, Zimmermann, Marc, additional, Zoche, Martin, additional, and Zuend, Gregor, additional

Published
2021
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9. Knowledge Gaps in Oncoplastic Breast Surgery

Author

Weber, Walter, Morrow, Monica, de Boniface, Jana, Pusic, Andrea L., Montagna, Giacomo, Kappos, Elizabeth A., Ritter, Mathilde, Saccilotto, Ramon, Schulz, Alexandra, Benson, John R., Fitzal, Florian, Matrai, Zoltan, Vrancken-Peeters, Marie-Jeanne, Potter, Shelley, and Heil, Joerg

Published
2020

10. Impact of Oncoplastic Breast Surgery on Rate of Complications, Time to Adjuvant Treatment, and Risk of Recurrence

Author

Oberhauser, Ida, primary, Zeindler, Jasmin, additional, Ritter, Mathilde, additional, Levy, Jeremy, additional, Montagna, Giacomo, additional, Mechera, Robert, additional, Soysal, Savas Deniz, additional, Castrezana López, Liliana, additional, D’Amico, Veronica, additional, Kappos, Elisabeth Artemis, additional, Schwab, Fabienne Dominique, additional, Müller, Madleina, additional, Kurzeder, Christian, additional, Haug, Martin, additional, and Weber, Walter Paul, additional

Published
2020
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11. Impact of Oncoplastic Breast Surgery on Rate of Complications, Time to Adjuvant Treatment, and Risk of Recurrence.

Author

Oberhauser, Ida, Zeindler, Jasmin, Ritter, Mathilde, Levy, Jeremy, Montagna, Giacomo, Mechera, Robert, Soysal, Savas Deniz, Castrezana López, Liliana, D'Amico, Veronica, Kappos, Elisabeth Artemis, Schwab, Fabienne Dominique, Müller, Madleina, Kurzeder, Christian, Haug, Martin, and Weber, Walter Paul

Subjects
SURGICAL complication risk factors, WOUND healing, CHRONIC pain, LYMPHEDEMA, ACADEMIC medical centers, CONFIDENCE intervals, TIME, PLASTIC surgery, CANCER relapse, RETROSPECTIVE studies, DISEASE incidence, DISEASES, RISK assessment, TUMOR classification, DESCRIPTIVE statistics, ONCOLOGIC surgery, COMBINED modality therapy, MASTECTOMY, ODDS ratio, BREAST tumors, NECROSIS, PROPORTIONAL hazards models, DISEASE risk factors
Abstract

Background: The aim of this study was to compare the risk of complications and recurrence between oncoplastic and conventional breast surgery. Methods: This is a retrospective analysis of a consecutive series of 436 patients with stage I–III breast cancer who underwent surgery at the University Hospital of Basel between 2011 and 2018. Results: The nipple/skin-sparing mastectomy (NSM/SSM) group showed significantly more delayed wound healing (32.7 vs. 5.8%, p < 0.001) and skin necrosis (13.9 vs. 1.9%, p = 0.020) compared to conventional mastectomy (CM), which corresponded to significantly higher odds of short-term complications (OR 2.34, 95% CI 1.02–5.35, p = 0.044). The incidence rate of long-term morbidity in oncoplastic breast-conserving surgery (OBCS) was significantly higher compared to conventional breast-conserving surgery (CBCS; 25.5 vs. 11.3 per 100 patient years [PY], p < 0.001), in particular concerning chronic pain (13.3 vs. 6.6, p = 0.011) and lymphedema (4.1 vs. 0.4, p = 0.003). Seroma as a long-term morbidity occurred more often in the CM group compared to the NSM/SSM group (5.8 vs. 0.5 per 100 PY, p = 0.004). Patients received adjuvant treatment earlier after CM compared to NSM/SSM (HR 1.83, 95% CI 1.05–3.19, p = 0.034). There were no significant differences in the incidence of positive margins nor in the odds of recurrence after OBCS versus CBCS and after NSM/SSM versus CM. Conclusions: Even though the present study confirmed expected differences in complications and morbidity, it suggested that oncoplastic surgery is oncologically safe. Patients undergoing NSM/SSM should be followed closely to allow early detection and treatment of frequently associated complications and ensure timely start of adjuvant therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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