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1. 2024 European Society of Hypertension clinical practice guidelines for the management of arterial hypertension

Author: Kreutz, R, Brunström, M, Burnier, M, Grassi, G, Januszewicz, A, Muiesan, M, Tsioufis, K, de Pinho, R, Albini, F, Boivin, J, Doumas, M, Nemcsik, J, Rodilla, E, Agabiti-Rosei, E, Algharably, E, Agnelli, G, Benetos, A, Hitij, J, Cífková, R, Cornelissen, V, Danser, A, Delles, C, Huelgas, R, Járai, Z, Palatini, P, Pathak, A, Persu, A, Polonia, J, Sarafidis, P, Stergiou, G, Thomopoulos, C, Wanner, C, Weber, T, Williams, B, Kjeldsen, S, Mancia, G, Kreutz, Reinhold, Brunström, Mattias, Burnier, Michel, Grassi, Guido, Januszewicz, Andrzej, Muiesan, Maria Lorenza, Tsioufis, Konstantinos, de Pinho, Rosa Maria, Albini, Fabio Lucio, Boivin, Jean-Marc, Doumas, Michalis, Nemcsik, János, Rodilla, Enrique, Agabiti-Rosei, Enrico, Algharably, Engi Abd Elhady, Agnelli, Giancarlo, Benetos, Athanase, Hitij, Jana Brguljan, Cífková, Renata, Cornelissen, Véronique, Danser, A H Jan, Delles, Christian, Huelgas, Ricardo Gómez, Járai, Zoltán, Palatini, Paolo, Pathak, Atul, Persu, Alexandre, Polonia, Jorge, Sarafidis, Pantelis, Stergiou, George, Thomopoulos, Costas, Wanner, Christoph, Weber, Thomas, Williams, Bryan, Kjeldsen, Sverre E, Mancia, Giuseppe, Kreutz, R, Brunström, M, Burnier, M, Grassi, G, Januszewicz, A, Muiesan, M, Tsioufis, K, de Pinho, R, Albini, F, Boivin, J, Doumas, M, Nemcsik, J, Rodilla, E, Agabiti-Rosei, E, Algharably, E, Agnelli, G, Benetos, A, Hitij, J, Cífková, R, Cornelissen, V, Danser, A, Delles, C, Huelgas, R, Járai, Z, Palatini, P, Pathak, A, Persu, A, Polonia, J, Sarafidis, P, Stergiou, G, Thomopoulos, C, Wanner, C, Weber, T, Williams, B, Kjeldsen, S, Mancia, G, Kreutz, Reinhold, Brunström, Mattias, Burnier, Michel, Grassi, Guido, Januszewicz, Andrzej, Muiesan, Maria Lorenza, Tsioufis, Konstantinos, de Pinho, Rosa Maria, Albini, Fabio Lucio, Boivin, Jean-Marc, Doumas, Michalis, Nemcsik, János, Rodilla, Enrique, Agabiti-Rosei, Enrico, Algharably, Engi Abd Elhady, Agnelli, Giancarlo, Benetos, Athanase, Hitij, Jana Brguljan, Cífková, Renata, Cornelissen, Véronique, Danser, A H Jan, Delles, Christian, Huelgas, Ricardo Gómez, Járai, Zoltán, Palatini, Paolo, Pathak, Atul, Persu, Alexandre, Polonia, Jorge, Sarafidis, Pantelis, Stergiou, George, Thomopoulos, Costas, Wanner, Christoph, Weber, Thomas, Williams, Bryan, Kjeldsen, Sverre E, and Mancia, Giuseppe
Published: 2024

2. Twenty-four-hour central (aortic) systolic blood pressure: Reference values and dipping patterns in untreated individuals

Author: Weber, T, Protogerou, A, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Binder, R, Blacher, J, Brandao, A, Cruz, J, Danninger, K, Giannatasio, C, Graciani, A, Hametner, B, Jankowski, P, Li, Y, Maloberti, A, Mayer, C, Mcdonnell, B, Mceniery, C, Gomes, M, Gomes, A, Muiesan, M, Nemcsik, J, Paini, A, Rodilla, E, Schutte, A, Sfikakis, P, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman, J, Wassertheurer, S, Weber T., Protogerou A. D., Agharazii M., Argyris A., Bahous S. A., Banegas J. R., Binder R. K., Blacher J., Brandao A. A., Cruz J. J., Danninger K., Giannatasio C., Graciani A., Hametner B., Jankowski P., Li Y., Maloberti A., Mayer C. C., McDonnell B. J., McEniery C. M., Gomes M. A. M., Gomes A. M., Muiesan M. L., Nemcsik J., Paini A., Rodilla E., Schutte A. E., Sfikakis P. P., Terentes-Printzios D., Vallee A., Vlachopoulos C., Ware L., Wilkinson I., Zweiker R., Sharman J. E., Wassertheurer S., Weber, T, Protogerou, A, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Binder, R, Blacher, J, Brandao, A, Cruz, J, Danninger, K, Giannatasio, C, Graciani, A, Hametner, B, Jankowski, P, Li, Y, Maloberti, A, Mayer, C, Mcdonnell, B, Mceniery, C, Gomes, M, Gomes, A, Muiesan, M, Nemcsik, J, Paini, A, Rodilla, E, Schutte, A, Sfikakis, P, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman, J, Wassertheurer, S, Weber T., Protogerou A. D., Agharazii M., Argyris A., Bahous S. A., Banegas J. R., Binder R. K., Blacher J., Brandao A. A., Cruz J. J., Danninger K., Giannatasio C., Graciani A., Hametner B., Jankowski P., Li Y., Maloberti A., Mayer C. C., McDonnell B. J., McEniery C. M., Gomes M. A. M., Gomes A. M., Muiesan M. L., Nemcsik J., Paini A., Rodilla E., Schutte A. E., Sfikakis P. P., Terentes-Printzios D., Vallee A., Vlachopoulos C., Ware L., Wilkinson I., Zweiker R., Sharman J. E., and Wassertheurer S.
Abstract: Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18-94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBPMAP/DBPcal), or bSBP/diastolic blood pressure (cSBPSBP/DBPcal), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBPMAP/DBPcal were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBPSBP/DBPcal, respectively. We pragmatically propose as upper normal limit for 24-hour cSBPMAP/DBPcal 135 mm Hg and for 24-hour cSBPSBP/DBPcal 120 mm Hg. bSBP dipping (nighttimedaytime/ daytime SBP) was -10.6 % in young participants and decreased with increasing age. Central SBPSBP/DBPcal dipping was less pronounced (-8.7% in young participants). In contrast, cSBPMAP/DBPcal dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation.
Published: 2022

3. Management of Patients with Suspected or Confirmed Antibiotic Allergy. Executive Summary of Guidance from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Allergy and Clinical Immunology (SEAIC), the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Intensive Medicine and Coronary Care Units (SEMICYUC)

Author: Paño-Pardo, JR, primary, Moreno Rodilla, E, additional, Cobo Sacristan, S, additional, Cubero Saldaña, JL, additional, Periañez Párraga, L, additional, del Pozo León, JL, additional, Retamar Genti, P, additional, Rodríguez Oviedo, A, additional, Torres Jaén, MJ, additional, Vidal-Cortes, P, additional, and Colás Sanz, C, additional
Published: 2022
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4. DRESS Syndrome Induced by a Gadolinium-Based Contrast Agent in a 13-Year-Old Boy

Author: Macías-Iglesias, EM, primary, Campanón-Toro, MV, additional, Moreno Rodilla, E, additional, de Arriba-Méndez, S, additional, Sobrino-García, M, additional, Gallardo-Higueras, A, additional, and Dávila, I, additional
Published: 2022
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5. ROLE OF ESTIMATING PULSE WAVE VELOCITY IN COMMUNITY PHARMACIES IN SPAIN COMPARED TO SCORE

Author: Rodilla E, Adell M, Vicente B, Oton B, Lidon C, Santiago C, Edelmira C, Rosario H, Sara M, Zeneida P, Rosa P, Javier R, Desire R, Fanny R, Luis S, Jose-Antonio C, Jose C, Ana G, Andrea M, and Teresa C
Published: 2022

6. Brachial-ankle pulse wave velocity with a custom device

Author: Bacaicoa C, Rico-Martin S, Morales E, Cunha P, Rodilla E, Lozano J, Bacaicoa M, and Munoz-Torrero J
Subjects: Brachial-ankle pulse wave velocity, abiPWV, Arterial stiffness, Cardiovascular risk factors
Abstract: Background and objectives: The brachial-ankle pulse wave velocity (baPWV) is one of the most widely used arterial stiffness variables for assessing vascular risk. The abiPWV is a device that calculates various PWVs and the blood pressure ankle-brachial index (ABI). The device can also determine baPWV. The aim of this study was to calculate the baPWV with abiPWV, validate it with a reference device (VaSera) and study its clinical usefulness. Patients and methods: We studied 113 patients (mean age, 53 +/- 12 years), 59 (52%) of whom were women, and 10 (8.8%) of whom had a previous cardiovascular event. The participants C. Sanchez Bacaicoa, S. Rico-Martin, E. Morales et al. were classified according to cardiovascular risk factors (CRFs) into group I (none), group II (1 or 2 CRFs) and group III (3 or more CRFs). The patients with a previous cardiovascular event were included in group III. All participants had their baPWV measured with abiPWV and VaSera. Results: The baPWV correlation between the 2 devices was r = 0.93 (p< .001), and the percentage error calculated with the Bland-Altman analysis was 4.5%. The baPWV measured with abiPWV (in m/s) was as follows: group I, 10.5 +/- 1.6; group II, 13.8 +/- 2.9 (p < .001 when compared with group I); and group III, 14.1 +/- 2.7 (p < .001 when compared with group I). There were no differences between groups II and III. The results with VaSera were comparable to those of abiPWV. Conclusions: Measuring baPWV with the abiPWV is safe and has a similar clinical utility to that of VaSera. Incorporating this function into the options of abiPWV makes it a complete device for assessing arterial stiffness. (C) 2020 Published by Elsevier Espana, S.L.U.
Published: 2021

7. May measurement month 2019: The global blood pressure screening campaign of the international society of hypertension

Author: Thomas, B, Aletta E, S, George S, S, Claudio, B, Dylan, B, Fadi, C, Suzie, C, Alejandro, D, Albertino, D, Walter, E, Arun Pulikkottil, J, Nadia, K, Yoshihiro, K, Anuj, M, Marcos J, M, Arun, M, Dinesh, N, Peter, N, Mansi, P, Dorairaj, P, Agustin, R, Pablo, R, Markus, S, Ulrike M, S, Maciej, T, Thomas, U, Richard, W, Jiguang, W, Bryan, W, Neil R, P, H Olsen, M, T West-Gustave, K, D Levy, P, Lee, V, L Connell, K, Hammoudi, N, Bovet, P, Viswanathan, B, Perl, S, K Kramer, B, Brady, A, O Oladapo, O, Chifamba, J, Y Goshu, D, M Kassie, D, A Gebru, S, A Ibrahim, T, Kabirou, S, Tavassoli, E, Zolfaghari, M, Yavari, V, Mishchenko, L, Matova, O, Kolenyk, T, Zelenenka, L, Fedorov, S, Dorobantu, M, Paval, A, Bittman, J, Mangat, B, Melville, S, Leung, A, Jessen, N, Dolan, E, Itoh, H, Pathak, A, De Backer, T, S Postadzhiyan, A, V Valoy-Tiburcio, O, R Gonzalez-Medina, A, G Valdez-Valoy, L, S Wyss, F, Mirrakhimov, E, K Nadar, S, I Barrientos, A, R Nwokocha, C, I Nwokocha, M, Picone, D, Yang, J, C Chia, Y, M Ching, S, F Ellenga Mbolla, B, M Kouala Landa, C, Y Houehanou, C, W Wahab, K, B Omotoso, A, Ortellado, J, Gonzales, G, M Ruilope, L, Rodilla, E, Molinero, A, J Woodiwiss, A, Orchard, A, Kruger, R, Brguljan, J, Bozic, N, O Konradi, A, P Rotar, O, Chazova, I, K Masupe, T, T Tlhakanelo, J, Motlhatlhedi, K, Stergiou, G, Doumas, M, Zebekakis, P, P Cappuccio, F, Barciela, C, Tay, T, Dashdorj, N, Tuvdendarjaa, K, Boldbaatar, K, T Lanas, F, Paccot, M, Ishaq, M, Sidique, S, Memon, F, N Najem, R, K Abu Alfa, A, Mallat, S, J Jozwiak, J, Banach, M, Janowski, P, Twumasi-Ankrah, B, A Myers-Hansen, G, K Tannor, E, F Neto, M, Kowlessur, S, Ori, B, Heecharan, J, A Fageh, H, A Derbi, H, M Msalam, O, M Goma, F, Syatalimi, C, Jr Tembo, P, Mukupa, M, L Ndhlovu, H, L Chirwa, M, M Mbeba, M, H Zelveian, P, N Hakobyan, Z, Gourgenyan, S, Cho, M, Lee, H, Shin, J, Parati, G, Grassi, G, Ferri, C, Tsinamdzgvrishvili, B, Gamkrelidze, A, Trapaidze, D, Barbosa, E, S Barroso, W, M Feitosa, A, M Azevedo, V, A Dias, L, N Garcia, G, Delgado, I, Burazeri, G, Qirjako, G, Ylli, A, Cumashi, R, P Costantini-Olmos, A, Morr, I, Chuki, E, Wang, T, Chen, W, Lin, H, Malik, F, R Choudhury, S, Abdullah Al Mamun, M, Ishraquzzaman, M, S Aljuraiban, G, Y Al Slail, F, K Aldhwailea, S, A Badawi, A, L Viet, N, A Tien, H, Dong, N, T Sinh, C, V Minh, H, K Son, T, K Katamba, F, B Buila, N, Dzudie, A, Kingue, S, Epie, N, Njomou, A, S Ndom, M, M Yusufali, A, M Bazargani, N, Bin Belaila, B, Agrawal, A, M Suhail, A, N Ogola, E, M Gitura, B, Mbau, L, K Nguchu, H, A Barasa, F, Gomez, E, A Alcocer, L, Rosas, M, Palomo, S, J Estrada, A, Lopez-Jaramillo, P, Sanchez-Vallejo, G, E Casanova, M, Arcos, E, Aroca, G, Koirala, B, Bhattarai, H, Pandey, G, Devkota, S, Koirala, S, Ranabhat, K, Khanal, P, B Adhikari, T, D Bonzon, D, D Ona, D, M Asis, L, A Balmores Jr, B, C Castillo, R, J Stisman, D, G Espeche, W, J Marin, M, L Ennis, I, Chen, X, Wang, H, Liu, M, Yin, X, Wang, X, Bhalla, S, Gupta, P, Verma, N, K Gupta, B, Sheikh, S, Wuerzner, G, Garré, L, Boggia, J, M Houenassi, D, A OctavioSeijas, J, M'buyamba-Kabangu, J, M Tshiswaka, T, Páll, D, Járai, Z, Hernández, R, Garcia Vásquez, F, A Lopez-Rivera, J, L Gúzman-Franolic, M, Victoria Pereira, S, J Fernandes, M, S Garcia, M, Gijon, T, Meira Da Cunha, V, Beaney, Thomas, Schutte, Aletta E, Stergiou, George S, Borghi, Claudio, Burger, Dylan, Charchar, Fadi, Cro, Suzie, Diaz, Alejandro, Damasceno, Albertino, Espeche, Walter, Jose, Arun Pulikkottil, Khan, Nadia, Kokubo, Yoshihiro, Maheshwari, Anuj, Marin, Marcos J, More, Arun, Neupane, Dinesh, Nilsson, Peter, Patil, Mansi, Prabhakaran, Dorairaj, Ramirez, Agustin, Rodriguez, Pablo, Schlaich, Markus, Steckelings, Ulrike M, Tomaszewski, Maciej, Unger, Thomas, Wainford, Richard, Wang, Jiguang, Williams, Bryan, Poulter, Neil R, Michael H Olsen, Kristin T West-Gustave, Phillip D Levy, Vivian W. Y. Lee, Kenneth L Connell, Naima N. H. Hammoudi, Pascal Bovet, Bharathi Viswanathan, Sabine Perl, Bernard K Kramer, Adrian J. B. Brady, Olulola O Oladapo, Jephat Chifamba, Dejuma Y Goshu, Desalew M Kassie, Sintayehu A Gebru, Toure A Ibrahim, Soumana Kabirou, Elham Tavassoli, Mahsa Zolfaghari, Vahideh Yavari, Larysa Mishchenko, Olena Matova, Tetiana Kolenyk, Liliiya Zelenenka, Sergiy Fedorov, Maria Dorobantu, Alexandra Paval, Jesse Bittman, Biri Mangat, Sarah Melville, Alexander Leung, Neusa Jessen, Eamon Dolan, Hiroshi N. A. Itoh, Atul Pathak, Tine L. M. De Backer, Arman S Postadzhiyan, Osiris V Valoy-Tiburcio, Angel R Gonzalez-Medina, Laura G Valdez-Valoy, Fernando S Wyss, Erkin Mirrakhimov, Sunil K Nadar, Ana I Barrientos, Chukwuemeka R Nwokocha, Magdalene I Nwokocha, Dean Picone, Jun Yang, Yook C Chia, Siew M Ching, Bertrand F Ellenga Mbolla, Christian M Kouala Landa, Corine Y Houehanou, Kolawole W Wahab, Ayodele B Omotoso, Jose Ortellado, Graciela Gonzales, Luis M Ruilope, Enrique Rodilla, Ana Molinero, Angela J Woodiwiss, Ane Orchard, Ruan Kruger, Jana Brguljan, Nina Bozic, Aleksandra O Konradi, Oxana P Rotar, Irian Chazova, Tiny K Masupe, John T Tlhakanelo, Keneilwe Motlhatlhedi, George Stergiou, Michalis Doumas, Pantelis Zebekakis, Francesco P Cappuccio, Carolina Barciela, Tricia Tay, Naranjargal Dashdorj, Khulan Tuvdendarjaa, Khatantuul Boldbaatar, Fernando T Lanas, Melanie Paccot, Mohammed Ishaq, Saulat Sidique, Feroz Memon, Robert N Najem, Ali K Abu Alfa, Samir M. J. Mallat, Jacek J Jozwiak, Maciej Banach, Piotr Janowski, Betty Twumasi-Ankrah, Gustavus A Myers-Hansen, Elliot K Tannor, Marisa F Neto, Sudhirsen Kowlessur, Bhooshun Ori, Jaysing Heecharan, Hatem A Fageh, Hawa A Derbi, Omara M Msalam, Fastone M Goma, Charity Syatalimi, Penias Jr Tembo, Musawa Mukupa, Henry L Ndhlovu, Maureen L Chirwa, Mary M Mbeba, Parounak H Zelveian, Zoya N Hakobyan, Svetlana Gourgenyan, Myeong-Chan Cho, Hae-Young Lee, Jinho Shin, Gianfranco Parati, Guido Grassi, Claudio Ferri, Bezhan Tsinamdzgvrishvili, Amiran Gamkrelidze, Dali Trapaidze, Eduardo C. D. Barbosa, Weimar S Barroso, Audes M Feitosa, Vanda M Azevedo, Luis A Dias, Glenda N Garcia, Isaulina Delgado, Genc Burazeri, Gentiana Qirjako, Alban Ylli, Rudina Cumashi, Antonieta P Costantini-Olmos, Igor Morr, Elias Chuki, Tzung-Dau Wang, Wen-Jone Chen, Hung-Ju Lin, Fazila-Tun-Nesa Malik, Sohel R Choudhury, Mohammad Abdullah Al Mamun, Mir Ishraquzzaman, Ghadeer S Aljuraiban, Fatima Y Al Slail, Shatha K Aldhwailea, Ann A Badawi, Nguyen L Viet, Hoang A Tien, Nguyen T. A. Dong, Cao T Sinh, Huynh V Minh, Tran K Son, Fortunat K Katamba, Nathan B Buila, Anastase Dzudie, Samuel Kingue, Njume Epie, Armel Njomou, Marie S Ndom, Afzalhussein M Yusufali, Nooshin M Bazargani, Buthaina A. Bin Belaila, Amrish Agrawal, Aisha M Suhail, Elijah N Ogola, Bernard M Gitura, Lilian Mbau, Hellen K Nguchu, Felix A Barasa, Enrique Gomez, Luis A Alcocer, Martin Rosas, Silvia Palomo, Alfredo J Estrada, Patricio Lopez-Jaramillo, Gregorio Sanchez-Vallejo, Maria E Casanova, Edgar Arcos, Gustavo Aroca, Bhagawan Koirala, Harikrishna Bhattarai, Ghanashyam Pandey, Surya Devkota, Sweta Koirala, Kamal Ranabhat, Pratik Khanal, Tara B Adhikari, Dolores D Bonzon, Deborah Ignacia D Ona, Leilani M Asis, Benjamin A Balmores Jr, Rafael C Castillo, Diego J Stisman, Walter G Espeche, Marcos J Marin, Irene L Ennis, Xin Chen, Hongyu Wang, Min Liu, Xinhua Yin, Xiaolong Wang, Sandeep Bhalla, Priyanka Gupta, Narsingh Verma, Bal K Gupta, Shehla Sheikh, Gregoire Wuerzner, Laura Garré, José Boggia, Dédonougbo M Houenassi, José A OctavioSeijas, Jean-René M'buyamba-Kabangu, Trésor M Tshiswaka, Dénes Páll, Zoltán Járai, Rafael Hernández, Fortunato Garcia Vásquez, Jesús A Lopez-Rivera, Monica L Gúzman-Franolic, Savarino Victoria Pereira, Mário J Fernandes, Maria S Garcia, Teresa Gijon, Vitoria V. B. Meira Da Cunha, Thomas, B, Aletta E, S, George S, S, Claudio, B, Dylan, B, Fadi, C, Suzie, C, Alejandro, D, Albertino, D, Walter, E, Arun Pulikkottil, J, Nadia, K, Yoshihiro, K, Anuj, M, Marcos J, M, Arun, M, Dinesh, N, Peter, N, Mansi, P, Dorairaj, P, Agustin, R, Pablo, R, Markus, S, Ulrike M, S, Maciej, T, Thomas, U, Richard, W, Jiguang, W, Bryan, W, Neil R, P, H Olsen, M, T West-Gustave, K, D Levy, P, Lee, V, L Connell, K, Hammoudi, N, Bovet, P, Viswanathan, B, Perl, S, K Kramer, B, Brady, A, O Oladapo, O, Chifamba, J, Y Goshu, D, M Kassie, D, A Gebru, S, A Ibrahim, T, Kabirou, S, Tavassoli, E, Zolfaghari, M, Yavari, V, Mishchenko, L, Matova, O, Kolenyk, T, Zelenenka, L, Fedorov, S, Dorobantu, M, Paval, A, Bittman, J, Mangat, B, Melville, S, Leung, A, Jessen, N, Dolan, E, Itoh, H, Pathak, A, De Backer, T, S Postadzhiyan, A, V Valoy-Tiburcio, O, R Gonzalez-Medina, A, G Valdez-Valoy, L, S Wyss, F, Mirrakhimov, E, K Nadar, S, I Barrientos, A, R Nwokocha, C, I Nwokocha, M, Picone, D, Yang, J, C Chia, Y, M Ching, S, F Ellenga Mbolla, B, M Kouala Landa, C, Y Houehanou, C, W Wahab, K, B Omotoso, A, Ortellado, J, Gonzales, G, M Ruilope, L, Rodilla, E, Molinero, A, J Woodiwiss, A, Orchard, A, Kruger, R, Brguljan, J, Bozic, N, O Konradi, A, P Rotar, O, Chazova, I, K Masupe, T, T Tlhakanelo, J, Motlhatlhedi, K, Stergiou, G, Doumas, M, Zebekakis, P, P Cappuccio, F, Barciela, C, Tay, T, Dashdorj, N, Tuvdendarjaa, K, Boldbaatar, K, T Lanas, F, Paccot, M, Ishaq, M, Sidique, S, Memon, F, N Najem, R, K Abu Alfa, A, Mallat, S, J Jozwiak, J, Banach, M, Janowski, P, Twumasi-Ankrah, B, A Myers-Hansen, G, K Tannor, E, F Neto, M, Kowlessur, S, Ori, B, Heecharan, J, A Fageh, H, A Derbi, H, M Msalam, O, M Goma, F, Syatalimi, C, Jr Tembo, P, Mukupa, M, L Ndhlovu, H, L Chirwa, M, M Mbeba, M, H Zelveian, P, N Hakobyan, Z, Gourgenyan, S, Cho, M, Lee, H, Shin, J, Parati, G, Grassi, G, Ferri, C, Tsinamdzgvrishvili, B, Gamkrelidze, A, Trapaidze, D, Barbosa, E, S Barroso, W, M Feitosa, A, M Azevedo, V, A Dias, L, N Garcia, G, Delgado, I, Burazeri, G, Qirjako, G, Ylli, A, Cumashi, R, P Costantini-Olmos, A, Morr, I, Chuki, E, Wang, T, Chen, W, Lin, H, Malik, F, R Choudhury, S, Abdullah Al Mamun, M, Ishraquzzaman, M, S Aljuraiban, G, Y Al Slail, F, K Aldhwailea, S, A Badawi, A, L Viet, N, A Tien, H, Dong, N, T Sinh, C, V Minh, H, K Son, T, K Katamba, F, B Buila, N, Dzudie, A, Kingue, S, Epie, N, Njomou, A, S Ndom, M, M Yusufali, A, M Bazargani, N, Bin Belaila, B, Agrawal, A, M Suhail, A, N Ogola, E, M Gitura, B, Mbau, L, K Nguchu, H, A Barasa, F, Gomez, E, A Alcocer, L, Rosas, M, Palomo, S, J Estrada, A, Lopez-Jaramillo, P, Sanchez-Vallejo, G, E Casanova, M, Arcos, E, Aroca, G, Koirala, B, Bhattarai, H, Pandey, G, Devkota, S, Koirala, S, Ranabhat, K, Khanal, P, B Adhikari, T, D Bonzon, D, D Ona, D, M Asis, L, A Balmores Jr, B, C Castillo, R, J Stisman, D, G Espeche, W, J Marin, M, L Ennis, I, Chen, X, Wang, H, Liu, M, Yin, X, Wang, X, Bhalla, S, Gupta, P, Verma, N, K Gupta, B, Sheikh, S, Wuerzner, G, Garré, L, Boggia, J, M Houenassi, D, A OctavioSeijas, J, M'buyamba-Kabangu, J, M Tshiswaka, T, Páll, D, Járai, Z, Hernández, R, Garcia Vásquez, F, A Lopez-Rivera, J, L Gúzman-Franolic, M, Victoria Pereira, S, J Fernandes, M, S Garcia, M, Gijon, T, Meira Da Cunha, V, Beaney, Thomas, Schutte, Aletta E, Stergiou, George S, Borghi, Claudio, Burger, Dylan, Charchar, Fadi, Cro, Suzie, Diaz, Alejandro, Damasceno, Albertino, Espeche, Walter, Jose, Arun Pulikkottil, Khan, Nadia, Kokubo, Yoshihiro, Maheshwari, Anuj, Marin, Marcos J, More, Arun, Neupane, Dinesh, Nilsson, Peter, Patil, Mansi, Prabhakaran, Dorairaj, Ramirez, Agustin, Rodriguez, Pablo, Schlaich, Markus, Steckelings, Ulrike M, Tomaszewski, Maciej, Unger, Thomas, Wainford, Richard, Wang, Jiguang, Williams, Bryan, Poulter, Neil R, Michael H Olsen, Kristin T West-Gustave, Phillip D Levy, Vivian W. Y. Lee, Kenneth L Connell, Naima N. H. Hammoudi, Pascal Bovet, Bharathi Viswanathan, Sabine Perl, Bernard K Kramer, Adrian J. B. Brady, Olulola O Oladapo, Jephat Chifamba, Dejuma Y Goshu, Desalew M Kassie, Sintayehu A Gebru, Toure A Ibrahim, Soumana Kabirou, Elham Tavassoli, Mahsa Zolfaghari, Vahideh Yavari, Larysa Mishchenko, Olena Matova, Tetiana Kolenyk, Liliiya Zelenenka, Sergiy Fedorov, Maria Dorobantu, Alexandra Paval, Jesse Bittman, Biri Mangat, Sarah Melville, Alexander Leung, Neusa Jessen, Eamon Dolan, Hiroshi N. A. Itoh, Atul Pathak, Tine L. M. De Backer, Arman S Postadzhiyan, Osiris V Valoy-Tiburcio, Angel R Gonzalez-Medina, Laura G Valdez-Valoy, Fernando S Wyss, Erkin Mirrakhimov, Sunil K Nadar, Ana I Barrientos, Chukwuemeka R Nwokocha, Magdalene I Nwokocha, Dean Picone, Jun Yang, Yook C Chia, Siew M Ching, Bertrand F Ellenga Mbolla, Christian M Kouala Landa, Corine Y Houehanou, Kolawole W Wahab, Ayodele B Omotoso, Jose Ortellado, Graciela Gonzales, Luis M Ruilope, Enrique Rodilla, Ana Molinero, Angela J Woodiwiss, Ane Orchard, Ruan Kruger, Jana Brguljan, Nina Bozic, Aleksandra O Konradi, Oxana P Rotar, Irian Chazova, Tiny K Masupe, John T Tlhakanelo, Keneilwe Motlhatlhedi, George Stergiou, Michalis Doumas, Pantelis Zebekakis, Francesco P Cappuccio, Carolina Barciela, Tricia Tay, Naranjargal Dashdorj, Khulan Tuvdendarjaa, Khatantuul Boldbaatar, Fernando T Lanas, Melanie Paccot, Mohammed Ishaq, Saulat Sidique, Feroz Memon, Robert N Najem, Ali K Abu Alfa, Samir M. J. Mallat, Jacek J Jozwiak, Maciej Banach, Piotr Janowski, Betty Twumasi-Ankrah, Gustavus A Myers-Hansen, Elliot K Tannor, Marisa F Neto, Sudhirsen Kowlessur, Bhooshun Ori, Jaysing Heecharan, Hatem A Fageh, Hawa A Derbi, Omara M Msalam, Fastone M Goma, Charity Syatalimi, Penias Jr Tembo, Musawa Mukupa, Henry L Ndhlovu, Maureen L Chirwa, Mary M Mbeba, Parounak H Zelveian, Zoya N Hakobyan, Svetlana Gourgenyan, Myeong-Chan Cho, Hae-Young Lee, Jinho Shin, Gianfranco Parati, Guido Grassi, Claudio Ferri, Bezhan Tsinamdzgvrishvili, Amiran Gamkrelidze, Dali Trapaidze, Eduardo C. D. Barbosa, Weimar S Barroso, Audes M Feitosa, Vanda M Azevedo, Luis A Dias, Glenda N Garcia, Isaulina Delgado, Genc Burazeri, Gentiana Qirjako, Alban Ylli, Rudina Cumashi, Antonieta P Costantini-Olmos, Igor Morr, Elias Chuki, Tzung-Dau Wang, Wen-Jone Chen, Hung-Ju Lin, Fazila-Tun-Nesa Malik, Sohel R Choudhury, Mohammad Abdullah Al Mamun, Mir Ishraquzzaman, Ghadeer S Aljuraiban, Fatima Y Al Slail, Shatha K Aldhwailea, Ann A Badawi, Nguyen L Viet, Hoang A Tien, Nguyen T. A. Dong, Cao T Sinh, Huynh V Minh, Tran K Son, Fortunat K Katamba, Nathan B Buila, Anastase Dzudie, Samuel Kingue, Njume Epie, Armel Njomou, Marie S Ndom, Afzalhussein M Yusufali, Nooshin M Bazargani, Buthaina A. Bin Belaila, Amrish Agrawal, Aisha M Suhail, Elijah N Ogola, Bernard M Gitura, Lilian Mbau, Hellen K Nguchu, Felix A Barasa, Enrique Gomez, Luis A Alcocer, Martin Rosas, Silvia Palomo, Alfredo J Estrada, Patricio Lopez-Jaramillo, Gregorio Sanchez-Vallejo, Maria E Casanova, Edgar Arcos, Gustavo Aroca, Bhagawan Koirala, Harikrishna Bhattarai, Ghanashyam Pandey, Surya Devkota, Sweta Koirala, Kamal Ranabhat, Pratik Khanal, Tara B Adhikari, Dolores D Bonzon, Deborah Ignacia D Ona, Leilani M Asis, Benjamin A Balmores Jr, Rafael C Castillo, Diego J Stisman, Walter G Espeche, Marcos J Marin, Irene L Ennis, Xin Chen, Hongyu Wang, Min Liu, Xinhua Yin, Xiaolong Wang, Sandeep Bhalla, Priyanka Gupta, Narsingh Verma, Bal K Gupta, Shehla Sheikh, Gregoire Wuerzner, Laura Garré, José Boggia, Dédonougbo M Houenassi, José A OctavioSeijas, Jean-René M'buyamba-Kabangu, Trésor M Tshiswaka, Dénes Páll, Zoltán Járai, Rafael Hernández, Fortunato Garcia Vásquez, Jesús A Lopez-Rivera, Monica L Gúzman-Franolic, Savarino Victoria Pereira, Mário J Fernandes, Maria S Garcia, Teresa Gijon, and Vitoria V. B. Meira Da Cunha
Abstract: Elevated blood pressure remains the single biggest risk factor contributing to the global burden of disease and mortality. May Measurement Month is an annual global screening campaign aiming to improve awareness of blood pressure at the individual and population level. Adults (≥18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally, 3 blood pressure readings were measured for each participant, and data on lifestyle factors and comorbidities were collected. Hypertension was defined as a systolic blood pressure ≥140 mm Hg, or a diastolic blood pressure ≥90 mm Hg (mean of the second and third readings) or taking antihypertensive medication. When necessary, multiple imputation was used to estimate participants' mean blood pressure. Mixed-effects models were used to evaluate associations between blood pressure and participant characteristics. Of 1 508 130 screenees 482 273 (32.0%) had never had a blood pressure measurement before and 513 337 (34.0%) had hypertension, of whom 58.7% were aware, and 54.7% were on antihypertensive medication. Of those on medication, 57.8% were controlled to <140/90 mm Hg, and 28.9% to <130/80 mm Hg. Of all those with hypertension, 31.7% were controlled to <140/90 mm Hg, and 350 825 (23.3%) participants had untreated or inadequately treated hypertension. Of those taking antihypertensive medication, half were taking only a single drug, and 25% reported using aspirin inappropriately. This survey is the largest ever synchronized and standardized contemporary compilation of global blood pressure data. This campaign is needed as a temporary substitute for systematic blood pressure screening in many countries worldwide.
Published: 2020

8. Analysis of the efficacy of an internet-based self-administered intervention ('Living Better') to promote healthy habits in a population with obesity and hypertension: An exploratory randomized controlled trial

Author: Mensorio MS, Cebolla-Martí A, Rodilla E, Palomar G, Lisón JF, Botella C, Fernández-Aranda F, Jimenez-Murcia S, and Baños RM
Subjects: Hypertension, Obesity, Overweight, Online intervention, Lifestyle change
Abstract: Introduction: Changes in unhealthy lifestyles are key elements in the prevention and treatment of obesity and hypertension. Internet-based programs offer great potential for the implementation of evidence-based interventions focused on promoting healthy habits. We evaluate the efficacy of an Internet-based self-administered program ("Living Better") that addresses people diagnosed as being overweight or having type I obesity and hypertension. Methods: The sample was composed of a total of 106 participants (age Mean = 53; 59 males) from a public hospital in Spain, diagnosed as being overweight or having type I obesity and hypertension and randomized into two groups-the intervention group (IG; Internet-based intervention) and the control group (CG; usual medical treatment). The intervention used cognitive-behavioral strategies and psychoeducation to promote healthy habits. Anthropometric data (i.e., Body Mass Index -BMI-, waist circumference, and hip circumference) and lifestyle/psychological data (i.e., quality of life, physical activity, eating styles, motivation, mood, and self-efficacy) were assessed before and after the intervention, and at 6 and 12-month follow-ups. Results: Significant differences were observed between the IG and the CG in anthropometrical variables after intervention (i.e., BMI and waist circumference), external eating style, and anxiety and stress scores (p < 0.05). Follow-up data showed that changes were maintained in BMI, waist and hip circumference, and external eating in the IG. After receiving the Internet-based treatment, the CG also improved its clinical condition. Discussion: This study demonstrates that the Internet is a viable alternative for the delivery and dissemination of interventions focused on promoting healthy habits, and a totally self-administered intervention can produce long-term positive results.
Published: 2019

9. 24-HOUR CENTRAL BLOOD PRESSURE: REFERENCE VALUES FOR HEALTHY INDIVIDUALS. THE INTERNATIONAL 24HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Author: Weber, T. Protogerou, A. Wassertheurer, S. Agharazii, M. and Argyris, A. Bahous, S. A. Banegas, J. R. Blacher, J. and Brandao, A. A. Cruz, J. J. Giannattasio, C. Jankowski, P. and Li, Y. Maloberti, A. McDonnel, B. McEniery, C. Mota Gomes, M. A. Machado Gomes, A. Graciani, A. Muiesan, M. L. and Nemcsik, J. Rodilla, E. Schutte, A. Terentes-Printzios, D. Vallee, A. Vlachopoulos, C. Ware, L. Wilkinson, I. and Zweiker, R. Sharman, J.
Published: 2019

10. Successful Bendamustine Desensitization for a Delayed-Type Hypersensitivity Reaction

Author: Martin Garcia, C, primary, Sierra Pacho, M, additional, Moreno Rodilla, E, additional, Callejo Melgosa, AM, additional, Martinez Alonso, JC, additional, Fernández Colino, T, additional, Acevedo del Barrio, G, additional, Gil Valiño, C, additional, and Eiris Aradas, MC, additional
Published: 2019
Full Text: View/download PDF

11. May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Author: Beaney, T, Burrell, LM, Castillo, RR, Charchar, FJ, Cro, S, Damasceno, A, Kruger, R, Nilsson, PM, Prabhakaran, D, Ramirez, AJ, Schlaich, MP, Schutte, AE, Tomaszewski, M, Touyz, R, Wang, J-G, Weber, MA, Poulter, NR, Burazeri, G, Qirjako, G, Roshi, E, Cunashi, R, Fernandes, MJCC, Pereira, SSV, Neto, MFMP, Oliveira, PNM, Feijao, ACG, Cerniello, Y, Marin, MJ, Vasquez, FG, Espeche, WG, Stisman, D, Fuentes, IA, Zilberman, JM, Rodriguez, P, Babinyan, KY, Engibaryan, AH, Avagyan, AM, Minasyan, AA, Gevorkyan, AT, Carnagarin, R, Carrington, MJ, Sharman, JE, Lee, R, Perl, S, Niederl, E, Malik, F-T-N, Choudhury, SR, Al Mamun, MA, Ishraquzzaman, M, Anthony, F, Connell, K, De Backer, TLM, Krzesinski, J, Houenassi, MD, Houehanou, CY, Sokolovic, S, Bahtijarevic, R, Tiro, MB, Mosepele, M, Masupe, TK, Barroso, WS, Gomes, MAM, Feitosa, ADM, Brandao, AA, Miranda, RD, Azevedo, VMAA, Dias, LM, Garcia, GDN, Martins, IPP, Dzudie, A, Kingue, S, Djomou, FAN, Njume, E, Khan, N, Lanas, FT, Garcia, MS, Paccot, MF, Torres, PI, Li, Y, Liu, M, Xu, L, Li, L, Chen, X, Deng, J, Zhao, W, Fu, L, Zhou, Y, Lopez-Jaramillo, P, Otero, J, Camacho, PA, Accini, JL, Sanchez, G, Arcos, E, Buyamba-Kabangu, J-RM, Katamba, FK, Ngoyi, GN, Buila, NM, Bayauli, PM, Mbolla, BFE, Bakekolo, PR, Landa, CMK, Kaky, GSK, Kramoh, EK, Ngoran, YNK, Olsen, MH, Valoy, LV, Santillan, M, Medina, ARG, Penaherrera, CE, Villalba, J, Ramirez, MI, Arteaga, F, Delgado, P, Beistline, H, Cappuccio, FP, Keitley, J, Tay, T, Goshu, DY, Kassie, DM, Gebru, SA, Pathak, A, Denolle, T, Tsinamdzgvrishvili, B, Trapaidze, D, Sturua, L, Abesadze, T, Grdzelidze, N, Grabfelder, M, Kramer, BK, Schmeider, RE, Twumasi-Ankrah, B, Tannor, EK, Lincoln, MD, Deku, EM, Quintana, FSW, Kenerson, J, Baptiste, EDJ, Saintilmond, WW, Barrientos, AL, Peiger, B, Lagos, AR, Forgas, MA, Lee, VWY, Tomlinson, BWY, Jarai, Z, Pall, D, More, A, Maheshwari, A, Verma, N, Sharma, M, Mukherjee, TK, Patil, M, Jose, AP, Takalkar, A, Turana, Y, Widyantoro, B, Danny, SS, 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J, Banach, M, Mastej, M, Rodrigues, MMDC, Martins, LL, Paval, A, Dorobantu, M, Konradi, AO, Chazova, IE, Rotar, O, Spoares, MC, Viegas, D, Almustafa, BA, Alshurafa, SA, Brady, A, Bovet, P, Viswanathan, B, Oladapo, OO, Russell, JW, Brguljan-Hitij, J, Bozic, N, Knez, J, Dolenc, P, Hassan, MM, Woodiwiss, AJ, Myburgh, C, Vally, M, Ruilope, LM, Molinero, A, Rodilla, E, Gijon-Conde, T, Beheiry, HM, Ali, IA, Osman, AAA, Fahal, NAW, Osman, HA, Altahir, F, Persson, M, Wuerzner, G, Burkard, T, Wang, T-D, Lin, H-J, Pan, H-Y, Chen, W-J, Lin, E, Mondo, CK, Ingabire, PM, Khomazyuk, TTA, Krotova, VV-Y, Negresku, E, Evstigneeva, O, Bazargani, NNB, Agrawal, A, Bin Belaila, BA, Suhail, AM, Muhammed, KO, Shuri, HH, Wainford, RD, Levy, PD, Boggia, JJG, Garre, LL, Hernandez-Hernandez, R, Octavio-Seijas, JA, Lopez-Rivera, JA, Morr, I, Duin, A, Huynh, MV, Cao, ST, Nguyen, VL, To, M, Phan, HN, Cockroft, J, McDonnell, B, Goma, FM, Syatalimi, C, Chifamba, J, Gwini, R, Xia, X, Tiburcio, OV, Beaney, T, Burrell, LM, Castillo, RR, Charchar, FJ, Cro, S, Damasceno, A, Kruger, R, Nilsson, PM, Prabhakaran, D, Ramirez, AJ, Schlaich, MP, Schutte, AE, Tomaszewski, M, Touyz, R, Wang, J-G, Weber, MA, Poulter, NR, Burazeri, G, Qirjako, G, Roshi, E, Cunashi, R, Fernandes, MJCC, Pereira, SSV, Neto, MFMP, Oliveira, PNM, Feijao, ACG, Cerniello, Y, Marin, MJ, Vasquez, FG, Espeche, WG, Stisman, D, Fuentes, IA, Zilberman, JM, Rodriguez, P, Babinyan, KY, Engibaryan, AH, Avagyan, AM, Minasyan, AA, Gevorkyan, AT, Carnagarin, R, Carrington, MJ, Sharman, JE, Lee, R, Perl, S, Niederl, E, Malik, F-T-N, Choudhury, SR, Al Mamun, MA, Ishraquzzaman, M, Anthony, F, Connell, K, De Backer, TLM, Krzesinski, J, Houenassi, MD, Houehanou, CY, Sokolovic, S, Bahtijarevic, R, Tiro, MB, Mosepele, M, Masupe, TK, Barroso, WS, Gomes, MAM, Feitosa, ADM, Brandao, AA, Miranda, RD, Azevedo, VMAA, Dias, LM, Garcia, GDN, Martins, IPP, Dzudie, A, Kingue, S, Djomou, FAN, Njume, E, Khan, N, Lanas, FT, Garcia, MS, Paccot, MF, Torres, PI, Li, Y, Liu, M, Xu, L, Li, L, Chen, X, Deng, J, Zhao, W, Fu, L, Zhou, Y, Lopez-Jaramillo, P, Otero, J, Camacho, PA, Accini, JL, Sanchez, G, Arcos, E, Buyamba-Kabangu, J-RM, Katamba, FK, Ngoyi, GN, Buila, NM, Bayauli, PM, Mbolla, BFE, Bakekolo, PR, Landa, CMK, Kaky, GSK, Kramoh, EK, Ngoran, YNK, Olsen, MH, Valoy, LV, Santillan, M, Medina, ARG, Penaherrera, CE, Villalba, J, Ramirez, MI, Arteaga, F, Delgado, P, Beistline, H, Cappuccio, FP, Keitley, J, Tay, T, Goshu, DY, Kassie, DM, Gebru, SA, Pathak, A, Denolle, T, Tsinamdzgvrishvili, B, Trapaidze, D, Sturua, L, Abesadze, T, Grdzelidze, N, Grabfelder, M, Kramer, BK, Schmeider, RE, Twumasi-Ankrah, B, Tannor, EK, Lincoln, MD, Deku, EM, Quintana, FSW, Kenerson, J, Baptiste, EDJ, Saintilmond, WW, Barrientos, AL, Peiger, B, Lagos, AR, Forgas, MA, Lee, VWY, Tomlinson, BWY, Jarai, Z, Pall, D, More, A, Maheshwari, A, Verma, N, Sharma, M, Mukherjee, TK, Patil, M, Jose, AP, Takalkar, A, Turana, Y, Widyantoro, B, Danny, SS, Djono, S, Handari, SD, Tambunan, M, Tiksnadi, BB, Hermiawaty, E, Tavassoli, E, Zolfaghari, M, Dolan, E, O'Brien, E, Borghi, C, Ferri, C, Torlasco, C, Parati, G, Nwokocha, CR, Nwokocha, MI, Ogola, EN, Gitura, BM, Barasa, AL, Barasa, FA, Wairagu, AW, Nalwa, WZ, Najem, RN, Abu Alfa, AK, Fageh, HA, Msalam, OM, Derbi, HA, Bettamar, KA, Zakauskiene, U, Vickiene, A, Calmes, J, Alkerwi, A, Gantenbein, M, Ndhlovu, HLL, Masiye, JK, Chirwa, ML, Nyirenda, NM, Dhlamini, TD, Chia, YC, Ching, SM, Devaraj, NK, Ouane, N, Fane, T, Kowlessur, S, Ori, B, Heecharan, J, Alcocer, L, Chavez, A, Ruiz, G, Espinosa, C, Gomez-Alvarez, E, Neupane, D, Bhattarai, H, Ranabhat, K, Adhikari, TB, Koirala, S, Toure, IA, Soumana, KH, Wahab, K, Omotoso, AB, Sani, MU, Okubadejo, NU, Nadar, SK, Al-Riyami, HA, Ishaq, M, Memon, F, Sidique, S, Choudhry, HA, Khan, RA, Ayala, M, Maidana, AJO, Bogado, GGG, Ona, DI, Atilano, A, Granada, C, Bartolome, R, Manese, L, Mina, A, Dumlao, MC, Villaruel, MC, Gomez, L, Jozwiak, J, Malyszko, J, Banach, M, Mastej, M, Rodrigues, MMDC, Martins, LL, Paval, A, Dorobantu, M, Konradi, AO, Chazova, IE, Rotar, O, Spoares, MC, Viegas, D, Almustafa, BA, Alshurafa, SA, Brady, A, Bovet, P, Viswanathan, B, Oladapo, OO, Russell, JW, Brguljan-Hitij, J, Bozic, N, Knez, J, Dolenc, P, Hassan, MM, Woodiwiss, AJ, Myburgh, C, Vally, M, Ruilope, LM, Molinero, A, Rodilla, E, Gijon-Conde, T, Beheiry, HM, Ali, IA, Osman, AAA, Fahal, NAW, Osman, HA, Altahir, F, Persson, M, Wuerzner, G, Burkard, T, Wang, T-D, Lin, H-J, Pan, H-Y, Chen, W-J, Lin, E, Mondo, CK, Ingabire, PM, Khomazyuk, TTA, Krotova, VV-Y, Negresku, E, Evstigneeva, O, Bazargani, NNB, Agrawal, A, Bin Belaila, BA, Suhail, AM, Muhammed, KO, Shuri, HH, Wainford, RD, Levy, PD, Boggia, JJG, Garre, LL, Hernandez-Hernandez, R, Octavio-Seijas, JA, Lopez-Rivera, JA, Morr, I, Duin, A, Huynh, MV, Cao, ST, Nguyen, VL, To, M, Phan, HN, Cockroft, J, McDonnell, B, Goma, FM, Syatalimi, C, Chifamba, J, Gwini, R, Xia, X, and Tiburcio, OV
Abstract: AIMS: Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. METHODS AND RESULTS: Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. CONCLUSION: May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk.
Published: 2019

12. 24-HOUR CENTRAL BLOOD PRESSURE: REFERENCE VALUES FOR HEALTHY INDIVIDUALS. THE INTERNATIONAL 24HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Author: Weber, T, Protogerou, A, Wassertheurer, S, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Blacher, J, Brandao, A, Cruz, J, Giannattasio, C, Jankowski, P, Li, Y, Maloberti, A, Mcdonnel, B, Mceniery, C, Mota Gomes, M, Machado Gomes, A, Graciani, A, Muiesan, M, Nemcsik, J, Rodilla, E, Schutte, A, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman., J, T. Weber, A. Protogerou, S. Wassertheurer, M. Agharazii, A. Argyris, S. A. Bahous, J. R. Banegas, J. Blacher, A. A. Brandao, J. J. Cruz, C. Giannattasio, P. Jankowski, Y. Li, A. Maloberti, B. McDonnel, C. McEniery, M. A. Mota Gomes, A. Machado Gomes, A. Graciani, M. L. Muiesan, J. Nemcsik, E. Rodilla, A. Schutte, D. Terentes-Printzios, A. Vallee, C. Vlachopoulos, L. Ware, I. Wilkinson, R. Zweiker, J. Sharman., Weber, T, Protogerou, A, Wassertheurer, S, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Blacher, J, Brandao, A, Cruz, J, Giannattasio, C, Jankowski, P, Li, Y, Maloberti, A, Mcdonnel, B, Mceniery, C, Mota Gomes, M, Machado Gomes, A, Graciani, A, Muiesan, M, Nemcsik, J, Rodilla, E, Schutte, A, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman., J, T. Weber, A. Protogerou, S. Wassertheurer, M. Agharazii, A. Argyris, S. A. Bahous, J. R. Banegas, J. Blacher, A. A. Brandao, J. J. Cruz, C. Giannattasio, P. Jankowski, Y. Li, A. Maloberti, B. McDonnel, C. McEniery, M. A. Mota Gomes, A. Machado Gomes, A. Graciani, M. L. Muiesan, J. Nemcsik, E. Rodilla, A. Schutte, D. Terentes-Printzios, A. Vallee, C. Vlachopoulos, L. Ware, I. Wilkinson, R. Zweiker, and J. Sharman.
Published: 2019

13. P1.14 PWV Improvement in Previously Untreated Mild Hypertensive Patients After 1 Year of Monotherapy

Author: Rodilla, E., Millasseau, S., Escriva, M., Garcia, J., Costa, J., and Pascual, J.
Published: 2014
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14. P7.9 Elevated Arterial Stiffness Precedes Development Of Hypertension in Never Treated Prehypertensive Patients

Author: Rodilla, E., Millasseau, S., Escriva, M., Garcia, J., Costa, J., and Pascual, J.
Published: 2014
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15. Effect of physical activity on pulse wave velocity in elderly subjects with normal glucose, prediabetes or Type 2 Diabetes

Author: Metsämarttila, E. (Erja), Rodilla, E. (Enrique), Jokelainen, J. (Jari), Herrala, S. (Sauli), Leppäluoto, J. (Juhani), and Keinänen-Kiukaanniemi, S. (Sirkka)
Subjects: cardiovascular system, cardiovascular diseases, circulatory and respiratory physiology
Abstract: Carotid-femoral pulse wave velocity ((cf)PWV) is a measure of arterial stiffness, predicting cardiovascular disease. We hypothesized that the amount of physical activity (PA) is correlated with reduced arterial stiffness in Type 2 diabetic (T2D) subjects. 570 subjects from the 1945 Oulu birth cohort were included in the analysis. (cf)PWV was determined by a non-invasive applanation tonometry. Oral glucose tolerance test was performed and LDL and HDL cholesterol analyzed. PA was registered daily with a wrist-worn acceleration meter for two weeks. (cf)PWV values in subjects with impaired glucose metabolism (IGM) and T2D were higher than in normal glycemic subjects (P
Published: 2018

16. Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Contrast Media

Author: Rosado Ingelmo, A., Dona Diaz, I, Cabanas Moreno, R., Moya Quesada, M. C., Garcia-Aviles, C., Garcia Nunez, I, Martinez Tadeo, J., I, Mielgo Ballesteros, R., Ortega-Rodriguez, N., Padial Vilchez, M. A., Sanchez-Morillas, L., Vila Albelda, C., Moreno Rodilla, E., Torres Jaen, M. J., [Rosado Ingelmo, A.] Hosp Univ Fdn Alcorcon, Unidad Alergia, C Budapest 1, Madrid 28922, Spain, [Vila Albelda, C.] Hosp Univ Fdn Alcorcon, Unidad Alergia, C Budapest 1, Madrid 28922, Spain, [Dona Diaz, I] UMA, IBIMA Reg Univ Hosp Malaga, Allergy Unit, Malaga, Spain, [Torres Jaen, M. J.] UMA, IBIMA Reg Univ Hosp Malaga, Allergy Unit, Malaga, Spain, [Cabanas Moreno, R.] Hosp La Paz, Hlth Res Inst IdiPAZ, Dept Allergy, Madrid, Spain, [Moya Quesada, M. C.] Secc Alergia CH Torrecardenas, Almeria, Spain, [Garcia-Aviles, C.] Hosp Moncloa, Unidad Alergia, Madrid, Spain, [Garcia Nunez, I] Hosp Quiron Malaga, Serv Alergol, Malaga, Spain, [Martinez Tadeo, J., I] Hosp Univ Ntra Sra Candelaria, Serv Alergol, Tenerife, Spain, [Mielgo Ballesteros, R.] Hosp Univ 12 Octubre, Serv Alergol, Madrid, Spain, [Ortega-Rodriguez, N.] Hosp Univ Gran Canaria Dr Negrin, Serv Alergol, Las Palmas Gran Canaria, Spain, [Padial Vilchez, M. A.] Hosp Infanta Sofia, Serv Alergol, Madrid, Spain, [Sanchez-Morillas, L.] Hosp Clin San Carlos, Serv Alergol, Madrid, Spain, and [Moreno Rodilla, E.] Complejo Asistencial Univ Salamanca, Serv Alergol, Salamanca, Spain
Subjects: Allergy, Drug-reactions, Contrast media, Radiocontrast media, Basophil activation test, Cross-reactivity, Gadolinium, Nonimmediate reactions, Adverse-reactions, Immediate reactions, Anaphylactoid reactions, Gadopentetate dimeglumine, Gadobenate dimeglumine, Hypersensitivity, Negative skin-tests, Iodinated, Anaphylaxis, Immediate allergic reactions
Abstract: The objective of these guidelines is to ensure efficient and effective clinical practice. The panel of experts who produced this consensus document developed a research protocol based on a review of the literature.The prevalence of allergic reactions to iodinated contrast media (ICM) is estimated to be 1:170 000, that is, 0.05%-0.1% of patients undergoing radiologic studies with ICM (more than 75 million examinations per year worldwide). Hypersensitivity reactions can appear within the first hour after administration (immediate reactions) or from more than 1 hour to several days after administration (nonimmediate or delayed reactions). The risk factors for immediate reactions include poorly controlled bronchial asthma, concomitant medication (eg, angiotensin-converting enzyme inhibitors, beta-blockers, and proton-pump inhibitors), rapid administration of the ICM, mastocytosis, autoimmune diseases, and viral infections.The most common symptoms of immediate reactions are erythema and urticaria with or without angioedema, which appear in more than 70% of patients. Maculopapular rash is the most common skin feature of nonimmediate reactions (30%-90%).Skin and in vitro tests should be performed for diagnosis of both immediate and nonimmediate reactions. The ICM to be administered will therefore be chosen depending on the results of these tests, the ICM that induced the reaction (when known), the severity of the reaction, the availability of alternative ICM, and the information available on potential ICM cross-reactivity.Another type of contrast media, gadolinium derivatives, is used used for magnetic resonance imaging. Although rare, IgE-mediated reactions to gadolinium derivatives have been reported.
Published: 2016

17. Adherence to Anaphylaxis Guidelines: Real-World Data From the Emergency Department of a Tertiary Hospital

Author: Ponce Guevara, LV, primary, Laffond Yges, E, additional, Gracia Bara, MT, additional, Moreno Rodilla, E, additional, Muñoz Bellido, FJ, additional, Lázaro Sastre, M, additional, Macías Iglesias, EM, additional, de Arriba Méndez, S, additional, Campanón Toro, MV, additional, and Dávila Gónzalez, I, additional
Published: 2018
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18. P4.07 Relationship Between Central and Peripheral Ambulatory and Office Blood Pressure with Left Ventricular Mass in Hypertensive Patients

Author: Rodilla, E., Costa, J. A., Tejero, S., and Pascual, J. M.
Published: 2012
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19. Arterial Destiffening in Previously Untreated Mild Hypertensives After 1 Year of Routine Clinical Management

Author: Rodilla E, Millasseau S, Costa JA, and Pascual JM
Subjects: arterial stiffness, hypertension, pulse wave velocity, target organ damage, real-life clinical practice, blood pressure
Abstract: BACKGROUND Arterial stiffness, measured with pulse wave velocity (PWV), is now classified as a marker of target organ damage (TOD) alongside left ventricular hypertrophy and moderately increased albuminuria. Interventional studies on treated hypertensive patients have shown that PWV could be improved. Our aim was to assess changes in arterial stiffness after 1 year of routine clinical practice in never-treated hypertensive patients. PATIENTS AND METHODS We studied 356 never-treated patients with suspected hypertension. After standard clinical assessment during which presence of TOD was evaluated, hypertension diagnosis was confirmed in 231 subjects who subsequently received standard routine care. Both hypertensive and the 125 controls came back for a follow-up visit after 1 year. RESULTS Hypertensive patients were slightly older (46 +/- 12 vs. 50 +/- 12 years, P < 0.001), with higher mean arterial pressure (MAP)-adjusted PWV compared to controls (8.6 +/- 2.0 vs. 8.0 +/- 1.7 m/s, P < 0.001) and 47% of them presented 1 or more TOD. After 1 year of treatment, MAP was similar in both groups (94.9 vs. 96.2 mm Hg; P = ns), but adjusted PWV remained significantly higher in the hypertensive patients (7.8 +/- 1.4 vs. 8.3 +/- 1.7 m/s, P = 0.004). The prevalence of elevated PWV was reduced from 20% to 12%. All antihypertensive drugs achieved the same blood pressure (BP) and PWV reduction with the exception of vasodilating beta-blockers which gave slightly better results probably due to heart rate reduction. CONCLUSION BP reduction in newly diagnosed hypertensive patients improves arterial stiffness within a year of real-life clinical practice. Patients with the highest PWV and the largest reduction of BP "destiffened" the most whatever antihypertensive class was used.
Published: 2017

20. Emotional eating as a mediator between anxiety and cholesterol in population with overweight and hypertension

Author: Mensorio MS, Cebolla A, Lison JF, Rodilla E, Palomar G, Miragall M, and Banos RM
Subjects: obesity, Cholesterol, hypertension, emotional eating, lipids (amino acids, peptides, and proteins), anxiety
Abstract: Although the relationship between cholesterol and mood states (especially anxiety) has been well studied, few researches have included the role of eating styles in this relationship. This study explored the associations among eating styles, negative emotional symptoms, and levels of cholesterol (and other medical variables) in a population with hypertension and overweight or obesity, analyzing the possible mediation mechanisms involved. A cross-sectional study was conducted in 68 adults with hypertension and overweight/obesity, and stepwise multiple regression analysis and mediation analyses were carried out to test the hypothesis that eating styles mediate the relationship between negative emotional symptoms and cholesterol. Several significant correlations among age, anthropometric, medical, and psychological variables (eating styles and negative emotional symptoms) were found. There was a significant indirect effect of anxiety on total cholesterol and LDL cholesterol through emotional eating. Results suggest that emotional eating has a relevant role in the rise in total and LDL cholesterol, acting as a mediator in the relationship between anxiety and cholesterol. This finding could have important implications, since it introduces a new variable in the relationship between emotions and cholesterol and, therefore, changes the way of understanding this relationship, and of treating high cholesterol in a hypertensive sample.
Published: 2017

21. Relationship Between 24-Hour Ambulatory Central Systolic Blood Pressure and Left Ventricular Mass: A Prospective Multicenter Study

Author: Weber, T, Wassertheurer, S, Schmidt trucksäss, A, Rodilla, E, Ablasser, C, Jankowski, P, Lorenza Muiesan, M, Giannattasio, C, Mang, C, Wilkinson, I, Kellermair, J, Hametner, B, Pascual, J, Zweiker, R, Czarnecka, D, Paini, A, Salvetti, M, Maloberti, A, Mceniery, C, GIANNATTASIO, CRISTINA, MALOBERTI, ALESSANDRO, Mceniery, C., Weber, T, Wassertheurer, S, Schmidt trucksäss, A, Rodilla, E, Ablasser, C, Jankowski, P, Lorenza Muiesan, M, Giannattasio, C, Mang, C, Wilkinson, I, Kellermair, J, Hametner, B, Pascual, J, Zweiker, R, Czarnecka, D, Paini, A, Salvetti, M, Maloberti, A, Mceniery, C, GIANNATTASIO, CRISTINA, MALOBERTI, ALESSANDRO, and Mceniery, C.
Abstract: We investigated the relationship between left ventricular mass and brachial office as well as brachial and central ambulatory systolic blood pressure in 7 European centers. Central systolic pressure was measured with a validated oscillometric device, using a transfer function, and mean/diastolic pressure calibration. M-mode images were obtained by echocardiography, and left ventricular mass was determined by one single reader blinded to blood pressure. We studied 289 participants (137 women) free from antihypertensive drugs (mean age: 50.8 years). Mean office blood pressure was 145/88 mm Hg and mean brachial and central ambulatory systolic pressures were 127 and 128 mm Hg, respectively. Mean left ventricular mass was 93.3 kg/m(2), and 25.6% had left ventricular hypertrophy. The correlation coefficient between left ventricular mass and brachial office, brachial ambulatory, and central ambulatory systolic pressure was 0.29, 0.41, and 0.47, respectively (P=0.003 for comparison between brachial office and central ambulatory systolic pressure and 0.32 for comparison between brachial and central ambulatory systolic pressure). The results were consistent for men and women, and young and old participants. The areas under the curve for prediction of left ventricular hypertrophy were 0.618, 0.635, and 0.666 for brachial office, brachial, and central ambulatory systolic pressure, respectively (P=0.03 for comparison between brachial and central ambulatory systolic pressure). In younger participants, central ambulatory systolic pressure was superior to both other measurements. Central ambulatory systolic pressure, measured with an oscillometric cuff, shows a strong trend toward a closer association with left ventricular mass and hypertrophy than brachial office/ambulatory systolic pressure
Published: 2017

22. An internet-based self-administered intervention for promoting healthy habits and weight loss in hypertensive people who are overweight or obese: a randomized controlled trial

Author: Banos RM, Mensorio MS, Cebolla A, Rodilla E, Palomar G, Lisón J, and Botella C
Subjects: Lifestyle changes, Hypertension, Internet-based interventions, Unguided interventions, Obesity and overweight
Abstract: Background: The prevalence of overweight and obesity is on the rise worldwide with severe physical and psychosocial consequences. One of the most dangerous is hypertension. Lifestyle changes related to eating behaviour and physical activity are the critical components in the prevention and treatment of hypertension and obesity. Data indicates that the usual procedures to promote these healthy habits in health services are either insufficient or not efficient enough. Internet has been shown to be an effective tool for the implementation of lifestyle interventions based on this type of problem. This study aims to assess the efficacy of a totally self-administered online intervention programme versus the usual medical care for obese and overweight participants with hypertension (from the Spanish public health care system) to promote healthy lifestyles (eating behaviour and physical activity). Method: A randomized controlled trial will be conducted with 100 patients recruited from the hypertension unit of a public hospital. Participants will be randomly assigned to one of two conditions: a) SII: a self-administered Internet-based intervention protocol; and b) MUC-medical usual care. The online intervention is an Internet-delivered, multimedia, interactive, self-administered programme, composed of nine modules designed to promote healthy eating habits and increase physical activity. The first five modules will be activated at a rate of one per week, and access for modules 5 to 9 will open every two weeks. Patients will be assessed at four points: before the intervention, after the intervention (3 months), and at 6 and 12 months (follow-up). The outcome variables will include blood pressure, and Body Mass Index, as primary outcome measures, and quality of life and other lifestyle and anthropometrical variables as secondary outcome measures. Discussion: The literature highlights the need for more studies on the benefits of using the Internet to promote lifestyle interventions. This study aims to investigate the efficiency of a totally self-administered Internet -+based programme for promoting healthy habits and improving the medical indicators of a hypertensive and overweight population.
Published: 2015

23. Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors

Author: Herbert A., Cruickshank J.K., Laurent S., Boutouyrie P., Shimada K., Kario K., Miyashita H., Eguchi K., Kohara K., Tabara Y., Imai Y., Ito S., Hashimoto J., Uchiba K., Suzuki H., Takenaka T., Takazawa K., Kino M., Yamashina A., Tomiyama H., Dohi Y., Takase H., Jouven X., Empana J.P., Pannier B., Thomas F., Prescott E., Janner J., McEniery C., Cockcroft J., Wilkinson I., Roman M.J., Devereux R.B., Teal V., Townsend R., Vermeersch S., Rietzschel E.R., Van Bortel L., De Buyzere M.L., Segers P., Gillebert T.C., Wang J.-G., Li Y., Lazar J., Salciccioli L., Cunha P., Oliveira P., Cotter J., Vila I., Sousa N., Chirinos J., Medina-Lezama J., Weber T., Rammer M., O'Rourke M.F., Bernd E., Lassnig E., Porodko M., Ammer M., Wassertheurer S., Adji A., Rosenkranz S., Punzengruber C., Kvas E., Dufouil C., Tzourio C., Nijpels G., Dekker J.M., Stehouwer C.D.A., Ferreira I., Twisk J.W., Smulders Y.M., Van De Laar R.J., Van Kallen C.J., Van Greevenbroek M.M., Schalkwijk C.G., Vlachopoulos C., Aznaouridis C., Terentes-Printzios D., Xaplanteris P., Stefanadis C., Schutte A.E., Fourie C.M.T., Van Rooyen J.M., Mahmud A., Feely J., Ghiadoni L., Stea F., Bruno R.M., Cartoni G., Armenia S., Taddei S., Seidlerova J., Vanek J., Filipovsky J., Mayer O., Jr., Lind L., Soveri I., Fellström B., Zilmer M., Cavallini M.C., Pini R., Di Bari M., Marchionni N., Masotti G., Schillaci G., Pucci G., Battista F., Settimi L., Crilly M.A., Kumar V., Clark H.J., Scott N.W., Macdonald A.G., Williams D.J., Hillis G.S., Lee A.J., De Vries A., Small G.R., Zanchetti A., Bilo G., Taurino C., McClure J.D., Schneider M.P., Kawecka-Jaszcz K., Stolarz-Skrzypek K., Klima L., Staessen J.A., Kuznetsova T., Redon J., Martinez F., Rosei E.A., Melander O., Zannad F., Rossignol P., Collin C., Lonati L., Dominiczak A.F., O'Rourke M., Petrak O., Štrauch B., Rosa J., Widimsky J., Pipingas A., Pase M.P., Grima N.A., Stough C., Harris E., Sellick L., Macpherson H., Pascualab J.M., Rodilla E., Costa J.A., Simon T., Delles C., Dymott J.A., Neisius U., Carty D.M., Fesler P., Muiesan M.L., Salvettia M., Paini A., Tisler A., Zofi, Nemeth K., Marton A., El Haj Othmane T., Cseprekal O., Studinger P., Ibrahim N.N.I.N., Rasool A.H.G., Rahman A.R.A., Wong A.R., Protogerou A.D., Papaioannou T.G., Sfikakis P.P., Fu Y., Hu J., Zhao L., Li N., Jiang X., Ok E., Demirci M.S., Gungor O., Orlova I.A., Blankova Z.N., Seredenina E.M., Ageev F.T., Barinova I.V., Bellien J., Iacob M., Thuillez C., Joannides, Erglis A., Mintale I., Latkovskis G., Berzina M., Zabunova M., Krallisa A., Smulyan H., Safar M., Zhadan A., Tselukyo V., Bregvadze T., Aydin A., Von Kodolitsch Y., MUMC+: HVC Pieken Maastricht Studie (9), Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), Promovendi ODB, Epidemiologie, RS: CARIM - R3 - Vascular biology, MUMC+: KIO Kemta (9), Obstetrie & Gynaecologie, The Reference Values for Arterial Measurements Collaboration, Universidade do Minho, and Ege Üniversitesi
Subjects: Adult, Male, medicine.medical_specialty, Percentile, Central pressure, Arteriosclerosis, Systole, Medicina Básica [Ciências Médicas], Population, Aged, Aorta, Arteries, Blood pressure, Humans, Pulse, Age Distribution, Blood Pressure, Blood Pressure Determination, Cardiovascular Diseases, Female, Healthy Volunteers, Middle Aged, Reference Values, Risk Factors, Sex Distribution, Young Adult, Disease, Internal medicine, Diabetes mellitus, Medicine, Young adult, education, Cardiology and Cardiovascular Medicine, education.field_of_study, business.industry, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, medicine.disease, Pulse pressure, Surgery, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, ComputingMethodologies_PATTERNRECOGNITION, Ciências Médicas::Medicina Básica, InformationSystems_MISCELLANEOUS, business
Abstract: PubMed ID: 25112663, Aims: Estimated central systolic blood pressure (cSBP) and amplification (Brachial SBP-cSBP) are non-invasive measures potentially prognostic of cardiovascular (CV) disease. No worldwide, multiple-device reference values are available. We aimed to establish reference values for a worldwide general population standardizing between the different available methods of measurement. How these values were significantly altered by cardiovascular risk factors (CVRFs) was then investigated. Methods and results: Existing data from population surveys and clinical trials were combined, whether published or not. Reference values of cSBP and amplification were calculatedas percentiles for 'Normal' (no CVRFs) and 'Reference' (any CVRFs) populations. We included 45 436 subjects out of 82 930 that were gathered from 77 studies of 53 centres. Included subjects were apparently healthy, not treated for hypertension or dyslipidaemia, and free from overt CV disease and diabetes. Values of cSBP and amplification were stratified by brachial blood pressure categories and age decade in turn, both being stratifiedbysex. Amplification decreased with age and more so in males than in females. Sex was the most powerful factor associated with amplification with 6.6 mmHg (5.8-7.4) higher amplification in males than in females. Amplification was marginally but significantly influenced by CVRFs, with smoking and dyslipidaemia decreasing amplification, but increased with increasing levels of blood glucose. Conclusion: Typical values of cSBP and amplification in a healthy population and a population free of traditional CVRFs are now available according to age, sex, and brachial BP, providing values included from different devices with a wide geographical representation. Amplification is significantly influenced by CVRFs, but differently in men and women. © 2014 Published on behalf of the European Society of Cardiology.
Published: 2014

24. Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Contrast Media

Author: Rosado Ingelmo, A, primary, Doña Diaz, I, additional, Cabañas Moreno, R, additional, Moya Quesada, M, additional, García-Avilés, C, additional, García Nuñez, I, additional, Martínez Tadeo, J, additional, Mielgo Ballesteros, R, additional, Ortega-Rodríguez, N, additional, Padial Vilchez, M, additional, Sánchez-Morillas, L, additional, Vila Albelda, C, additional, Moreno Rodilla, E, additional, and Torres Jaén, M, additional
Published: 2016
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25. Experience on Series Production of the Superconducting Magnet Package for the Linear Accelerator of the European XFEL

Author: Martinez, T., primary, Abramian, P., additional, Calero, J., additional, Garcia-Tabares, L., additional, Rodriguez, E., additional, Sanchez, L., additional, Toral, F., additional, Brueck, H., additional, Bandelmann, R., additional, Iturbe, R., additional, Lopez, B., additional, Gomez, J., additional, and Rodilla, E., additional
Published: 2014
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26. Experimental analysis of direct thermal methane cracking

Author: Abánades Velasco, Alberto, Martínez-Val Peñalosa, José María, Ruíz, E., Ferruelo, E. M., Hernández, F., Cabanillas, A., Rubio, J. A., López, C., Gavela, R., Barrera, G., Rubbia, C., Salmieri, D., Rodilla, E., Gutiérrez, D., Abánades Velasco, Alberto, Martínez-Val Peñalosa, José María, Ruíz, E., Ferruelo, E. M., Hernández, F., Cabanillas, A., Rubio, J. A., López, C., Gavela, R., Barrera, G., Rubbia, C., Salmieri, D., Rodilla, E., and Gutiérrez, D.
Abstract: The analysis of the viability of Hydrogen production without CO2 emissions is one of the most challenging activities that have been initiated for a sustainable energy supply. As one of the tracks to fulfil such objective, direct methane cracking has been analysed experimentally to assess the scientific viability and reaction characterization in a broad temperature range, from 875 to 1700 ?C. The effect of temperature, sweeping/carrier gas fraction proposed in some concepts, methane flow rate, residence time, and tube material and porosity has been analysed. The aggregation of carbon black particles to the reaction tube is the main technological show-stopper that has been identified.
Published: 2011

27. Elevated arterial stiffness precedes development of hypertension in never treated prehypertensive patients

Author: Rodilla, E., Millasseau, S., Escriva, M., Garcia, J., Costa, J., and Pascual, J.
Published: 2014
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28. Relationship between central and peripheral ambulatory and office blood pressure with left ventricular mass in hypertensive patients

Author: Rodilla, E., Costa, J.A., Tejero, S., and Pascual, J.M.
Published: 2012
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29. PWV improvement in previously untreated mild hypertensive patients after 1 year of monotherapy.

Author: Rodilla, E., Millasseau, S., Escriva, M., Garcia, J., Costa, J., and Pascual, J.
Published: 2014
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30. Twenty-fourhour central (aortic) systolic blood pressure : reference values and dipping patterns in untreated individuals

Author: James E. Sharman, José R. Banegas, Anna Paini, János Nemcsik, Ronald K. Binder, Marco Antonio Mota Gomes, Thomas Weber, Yan Li, Maria Lorenza Muiesan, Alessandro Maloberti, Jacques Blacher, Alexandre Vallée, Aletta E. Schutte, Bernhard Hametner, Annelise Costa Machado Gomes, Cristina Giannatasio, Piotr Jankowski, Barry J. McDonnell, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Carmel M. McEniery, Petros P. Sfikakis, Christopher C. Mayer, Juan J. de la Cruz, Athanase D. Protogerou, Siegfried Wassertheurer, Enrique Rodilla, Sola Aoun Bahous, Mohsen Agharazii, Auxiliadora Graciani, Kathrin Danninger, Andréa Araujo Brandão, Lisa J. Ware, Antonis Argyris, Ian B. Wilkinson, Robert Zweiker, Weber, T, Protogerou, A, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Binder, R, Blacher, J, Brandao, A, Cruz, J, Danninger, K, Giannatasio, C, Graciani, A, Hametner, B, Jankowski, P, Li, Y, Maloberti, A, Mayer, C, Mcdonnell, B, Mceniery, C, Gomes, M, Gomes, A, Muiesan, M, Nemcsik, J, Paini, A, Rodilla, E, Schutte, A, Sfikakis, P, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman, J, Wassertheurer, S, Producción Científica UCH 2022, and UCH. Departamento de Medicina y Cirugía
Subjects: Adult, Male, medicine.medical_specialty, Hipertensión, hypertension, Ritmo cardíaco, Adolescent, Brachial Artery, Young Adult, Reference Values, Internal medicine, Heart rate, Hypertension, Internal Medicine, medicine, heart rate, 80 and over, Humans, Arterial Pressure, Blood pressure, Aged, Aged, 80 and over, Pulse, arterial pressure, blood pressure, Blood Pressure, Blood Pressure Determination, Circadian Rhythm, Female, Middle Aged, business.industry, Original Articles, Presión sanguínea, Reference values, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Cardiology, business
Abstract: Supplemental Digital Content is available in the text., Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18–94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBPMAP/DBPcal), or bSBP/diastolic blood pressure (cSBPSBP/DBPcal), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBPMAP/DBPcal were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBPSBP/DBPcal, respectively. We pragmatically propose as upper normal limit for 24-hour cSBPMAP/DBPcal 135 mm Hg and for 24-hour cSBPSBP/DBPcal 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was −10.6 % in young participants and decreased with increasing age. Central SBPSBP/DBPcal dipping was less pronounced (−8.7% in young participants). In contrast, cSBPMAP/DBPcal dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation.
Published: 2022

31. Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19

Author: Andrea Mendizabal, Marcos Guzmán-García, Elisa Rabadán-Pejenaute, Jose D Torres-Peña, Marta Nataya Solís-Marquínez, María Dolores Martín-Escalante, Araceli Pineda-Cantero, Maria Del Pilar Fidalgo-Montero, Francisco Javier Carrasco-Sánchez, Enrique Rodilla, Joaquín Fernandez López-Cuervo, María Esther Guisado-Espartero, Ricardo Gil-Sánchez, Lucy Abella-Vázquez, Ángel Luis Martínez-González, Ricardo Gómez-Huelgas, José Manuel Casas-Rojo, Elizabeth Lorenzo-Hernández, Joaquín Escobar-Sevilla, Julio González-Moraleja, Andrés de la Peña-Fernández, Vicente Giner-Galvañ, Alberto Saura, Ramon Boixeda, Iratxe Jimenez, UCH. Departamento de Medicina y Cirugía, Producción Científica UCH 2020, [Rodilla,E, Saura,A, Jiménez,I, Mendizábal,A] Internal Medicine Department, University Hospital of Sagunto, Universidad Cardenal Herrera-CEU, CEU Universities, Sagunto, Spain. [Pineda-Cantero,A, Lorenzo-Hernández,E, and Gómez-Huelgas,R] Internal Medicine Department, Regional University Hospital of Málaga, Málaga, Spain. [Fidalgo-Montero,MP] Internal Medicine Department, Henares Hospital, Coslada (Madrid), Spain. [Fernandez López-Cuervo,J] Internal Medicine Department, Torrevieja University Hospital, Torrevieja (Alicante), Spain. [Gil-Sánchez,R] Internal Medicine Department, La Fe University Hospital, Valencia, Spain. [Rabadán-Pejenaute,E] Internal Medicine Department, San Pedro Hospital, Logroño (La Rioja), Spain. [Abella-Vázquez,L] Internal Medicine Department, Ntra Sra Candelaria University Hospital, Santa Cruz de Tenerife, Spain. [Giner-Galvañ,V] Internal Medicine Department, Hypertension and Cardiometabolic Risk Unit, San Juan de Alicante University Hospital, Miguel Hernández University, San Juan de Alicante (Alicante), Spain. [Solís-Marquínez,MN] Internal Medicine Department, San Agustin University Hospital, Avilés (Asturias), Spain. [Boixeda,R] Internal Medicine Department, Mataró Hospital, Mataró, Barcelona, Spain. [de la Peña-Fernández,A] Internal Medicine Department, Son Llàtzer University Hospital, Palma de Mallorca, Spain. [Carrasco-Sánchez,FJ] Internal Medicine Department, Juan Ramón Jiménez Hospital, Huelva, Spain. [González-Moraleja,J] Internal Medicine Department, Virgen de la Salud Hospital, Toledo, Spain. [Torres-Peña,JD] Internal Medicine Department, Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain. [Guisado-Espartero,ME] Internal Medicine Department, Infanta Margarita Hospital, Cabra (Córdoba), Spain. [Escobar-Sevilla,J] Internal Medicine Department, Virgen de las Nieves University Hospital, Granada, Spain. [Guzmán-García,M] Internal Medicine Department, San Juan de la Cruz Hospital, Úbeda (Jaén), Spain. [Martín-Escalante,MD] Internal Medicine Department, Costa del Sol Hospital, Marbella (Málaga), Spain. [Martínez-González,AL] Internal Medicine Department, León University Hospital Complex, León, Spain. [Casas-Rojo,JM] Internal Medicine Department, Infanta Cristina University Hospital, Parla (Madrid), Spain.
Subjects: Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Cardiovascular Agents::Antihypertensive Agents [Medical Subject Headings], Hipertensión, Multivariate analysis, Physiology, lcsh:Medicine, Disease, 030204 cardiovascular system & hematology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, SARS-CoV-2 (Virus) - Pacientes - Mortalidad, 030212 general & internal medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Cause of Death [Medical Subject Headings], Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Vital Statistics::Mortality [Medical Subject Headings], Atrial fibrillation, General Medicine, Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity [Medical Subject Headings], humanities, Population study, all-cause mortality, Inhibidores de la enzima convertidora de angiotensina, Cardiology and Cardiovascular Medicine, angiotensin-converting enzyme inhibitors (ACEIs), medicine.medical_specialty, angiotensin II receptor blockers (ARBs), hypertension, Infecciones por coronavirus, Antagonistas de receptores de angiotensina, COVID-19 (Disease) - Patients - Mortality, Lower risk, Article, Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension [Medical Subject Headings], 03 medical and health sciences, Internal medicine, Diabetes mellitus, Hypertension, Internal Medicine, medicine, Risk factor, COVID-19, all-cause mortality, angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitors (ACEIs), hypertension, COVID-19 - Pacientes - Mortalidad, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, lcsh:R, COVID-19, medicine.disease, Comorbidity, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], SARS-CoV-2 (Virus) - Patients - Mortality, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Hospital Mortality [Medical Subject Headings], Observational study, business, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protease Inhibitors::Angiotensin-Converting Enzyme Inhibitors [Medical Subject Headings]
Abstract: It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 &plusmn, 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs.
Published: 2020

32. May Measurement Month 2019: The Global Blood Pressure Screening Campaign of the International Society of Hypertension

Author: Beaney, Thomas, Schutte, Aletta E, Stergiou, George S, Borghi, Claudio, Burger, Dylan, Charchar, Fadi, Cro, Suzie, Diaz, Alejandro, Damasceno, Albertino, Espeche, Walter, Jose, Arun Pulikkottil, Khan, Nadia, Kokubo, Yoshihiro, Maheshwari, Anuj, Marin, Marcos J, More, Arun, Neupane, Dinesh, Nilsson, Peter, Patil, Mansi, Prabhakaran, Dorairaj, Ramirez, Agustin, Rodriguez, Pablo, Schlaich, Markus, Steckelings, Ulrike M, Tomaszewski, Maciej, Unger, Thomas, Wainford, Richard, Wang, Jiguang, Williams, Bryan, Poulter, Neil R, Michael H Olsen, Kristin T West-Gustave, Phillip D Levy, Vivian W. Y. Lee, Kenneth L Connell, Naima N. H. Hammoudi, Pascal Bovet, Bharathi Viswanathan, Sabine Perl, Bernard K Kramer, Adrian J. B. Brady, Olulola O Oladapo, Jephat Chifamba, Dejuma Y Goshu, Desalew M Kassie, Sintayehu A Gebru, Toure A Ibrahim, Soumana Kabirou, Elham Tavassoli, Mahsa Zolfaghari, Vahideh Yavari, Larysa Mishchenko, Olena Matova, Tetiana Kolenyk, Liliiya Zelenenka, Sergiy Fedorov, Maria Dorobantu, Alexandra Paval, Jesse Bittman, Biri Mangat, Sarah Melville, Alexander Leung, Neusa Jessen, Eamon Dolan, Hiroshi N. A. Itoh, Atul Pathak, Tine L. M. De Backer, Arman S Postadzhiyan, Osiris V Valoy-Tiburcio, Angel R Gonzalez-Medina, Laura G Valdez-Valoy, Fernando S Wyss, Erkin Mirrakhimov, Sunil K Nadar, Ana I Barrientos, Chukwuemeka R Nwokocha, Magdalene I Nwokocha, Dean Picone, Jun Yang, Yook C Chia, Siew M Ching, Bertrand F Ellenga Mbolla, Christian M Kouala Landa, Corine Y Houehanou, Kolawole W Wahab, Ayodele B Omotoso, Jose Ortellado, Graciela Gonzales, Luis M Ruilope, Enrique Rodilla, Ana Molinero, Angela J Woodiwiss, Ane Orchard, Ruan Kruger, Jana Brguljan, Nina Bozic, Aleksandra O Konradi, Oxana P Rotar, Irian Chazova, Tiny K Masupe, John T Tlhakanelo, Keneilwe Motlhatlhedi, George Stergiou, Michalis Doumas, Pantelis Zebekakis, Francesco P Cappuccio, Carolina Barciela, Tricia Tay, Naranjargal Dashdorj, Khulan Tuvdendarjaa, Khatantuul Boldbaatar, Fernando T Lanas, Melanie Paccot, Mohammed Ishaq, Saulat Sidique, Feroz Memon, Robert N Najem, Ali K Abu Alfa, Samir M. J. Mallat, Jacek J Jozwiak, Maciej Banach, Piotr Janowski, Betty Twumasi-Ankrah, Gustavus A Myers-Hansen, Elliot K Tannor, Marisa F Neto, Sudhirsen Kowlessur, Bhooshun Ori, Jaysing Heecharan, Hatem A Fageh, Hawa A Derbi, Omara M Msalam, Fastone M Goma, Charity Syatalimi, Penias Jr Tembo, Musawa Mukupa, Henry L Ndhlovu, Maureen L Chirwa, Mary M Mbeba, Parounak H Zelveian, Zoya N Hakobyan, Svetlana Gourgenyan, Myeong-Chan Cho, Hae-Young Lee, Jinho Shin, Gianfranco Parati, Guido Grassi, Claudio Ferri, Bezhan Tsinamdzgvrishvili, Amiran Gamkrelidze, Dali Trapaidze, Eduardo C. D. Barbosa, Weimar S Barroso, Audes M Feitosa, Vanda M Azevedo, Luis A Dias, Glenda N Garcia, Isaulina Delgado, Genc Burazeri, Gentiana Qirjako, Alban Ylli, Rudina Cumashi, Antonieta P Costantini-Olmos, Igor Morr, Elias Chuki, Tzung-Dau Wang, Wen-Jone Chen, Hung-Ju Lin, Fazila-Tun-Nesa Malik, Sohel R Choudhury, Mohammad Abdullah Al Mamun, Mir Ishraquzzaman, Ghadeer S Aljuraiban, Fatima Y Al Slail, Shatha K Aldhwailea, Ann A Badawi, Nguyen L Viet, Hoang A Tien, Nguyen T. A. Dong, Cao T Sinh, Huynh V Minh, Tran K Son, Fortunat K Katamba, Nathan B Buila, Anastase Dzudie, Samuel Kingue, Njume Epie, Armel Njomou, Marie S Ndom, Afzalhussein M Yusufali, Nooshin M Bazargani, Buthaina A. Bin Belaila, Amrish Agrawal, Aisha M Suhail, Elijah N Ogola, Bernard M Gitura, Lilian Mbau, Hellen K Nguchu, Felix A Barasa, Enrique Gomez, Luis A Alcocer, Martin Rosas, Silvia Palomo, Alfredo J Estrada, Patricio Lopez-Jaramillo, Gregorio Sanchez-Vallejo, Maria E Casanova, Edgar Arcos, Gustavo Aroca, Bhagawan Koirala, Harikrishna Bhattarai, Ghanashyam Pandey, Surya Devkota, Sweta Koirala, Kamal Ranabhat, Pratik Khanal, Tara B Adhikari, Dolores D Bonzon, Deborah Ignacia D Ona, Leilani M Asis, Benjamin A Balmores Jr, Rafael C Castillo, Diego J Stisman, Walter G Espeche, Marcos J Marin, Irene L Ennis, Xin Chen, Hongyu Wang, Min Liu, Xinhua Yin, Xiaolong Wang, Sandeep Bhalla, Priyanka Gupta, Narsingh Verma, Bal K Gupta, Shehla Sheikh, Gregoire Wuerzner, Laura Garré, José Boggia, Dédonougbo M Houenassi, José A OctavioSeijas, Jean-René M'buyamba-Kabangu, Trésor M Tshiswaka, Dénes Páll, Zoltán Járai, Rafael Hernández, Fortunato Garcia Vásquez, Jesús A Lopez-Rivera, Monica L Gúzman-Franolic, Savarino Victoria Pereira, Mário J Fernandes, Maria S Garcia, Teresa Gijon, Vitoria V. B. Meira Da Cunha, Beaney T, Schutte AE, Stergiou GS, Borghi C, Burger D, Charchar F, Cro S, Diaz A, Damasceno A, Espeche W, Jose AP, Khan N, Kokubo Y, Maheshwari A, Marin MJ, More A, Neupane D, Nilsson P, Patil M, Prabhakaran D, Ramirez A, Rodriguez P, Schlaich M, Steckelings UM, Tomaszewski M, Unger T, Wainford R, Wang J, Williams B, Poulter NR, Thomas, B, Aletta E, S, George S, S, Claudio, B, Dylan, B, Fadi, C, Suzie, C, Alejandro, D, Albertino, D, Walter, E, Arun Pulikkottil, J, Nadia, K, Yoshihiro, K, Anuj, M, Marcos J, M, Arun, M, Dinesh, N, Peter, N, Mansi, P, Dorairaj, P, Agustin, R, Pablo, R, Markus, S, Ulrike M, S, Maciej, T, Thomas, U, Richard, W, Jiguang, W, Bryan, W, Neil R, P, H Olsen, M, T West-Gustave, K, D Levy, P, Lee, V, L Connell, K, Hammoudi, N, Bovet, P, Viswanathan, B, Perl, S, K Kramer, B, Brady, A, O Oladapo, O, Chifamba, J, Y Goshu, D, M Kassie, D, A Gebru, S, A Ibrahim, T, Kabirou, S, Tavassoli, E, Zolfaghari, M, Yavari, V, Mishchenko, L, Matova, O, Kolenyk, T, Zelenenka, L, Fedorov, S, Dorobantu, M, Paval, A, Bittman, J, Mangat, B, Melville, S, Leung, A, Jessen, N, Dolan, E, Itoh, H, Pathak, A, De Backer, T, S Postadzhiyan, A, V Valoy-Tiburcio, O, R Gonzalez-Medina, A, G Valdez-Valoy, L, S Wyss, F, Mirrakhimov, E, K Nadar, S, I Barrientos, A, R Nwokocha, C, I Nwokocha, M, Picone, D, Yang, J, C Chia, Y, M Ching, S, F Ellenga Mbolla, B, M Kouala Landa, C, Y Houehanou, C, W Wahab, K, B Omotoso, A, Ortellado, J, Gonzales, G, M Ruilope, L, Rodilla, E, Molinero, A, J Woodiwiss, A, Orchard, A, Kruger, R, Brguljan, J, Bozic, N, O Konradi, A, P Rotar, O, Chazova, I, K Masupe, T, T Tlhakanelo, J, Motlhatlhedi, K, Stergiou, G, Doumas, M, Zebekakis, P, P Cappuccio, F, Barciela, C, Tay, T, Dashdorj, N, Tuvdendarjaa, K, Boldbaatar, K, T Lanas, F, Paccot, M, Ishaq, M, Sidique, S, Memon, F, N Najem, R, K Abu Alfa, A, Mallat, S, J Jozwiak, J, Banach, M, Janowski, P, Twumasi-Ankrah, B, A Myers-Hansen, G, K Tannor, E, F Neto, M, Kowlessur, S, Ori, B, Heecharan, J, A Fageh, H, A Derbi, H, M Msalam, O, M Goma, F, Syatalimi, C, Jr Tembo, P, Mukupa, M, L Ndhlovu, H, L Chirwa, M, M Mbeba, M, H Zelveian, P, N Hakobyan, Z, Gourgenyan, S, Cho, M, Lee, H, Shin, J, Parati, G, Grassi, G, Ferri, C, Tsinamdzgvrishvili, B, Gamkrelidze, A, Trapaidze, D, Barbosa, E, S Barroso, W, M Feitosa, A, M Azevedo, V, A Dias, L, N Garcia, G, Delgado, I, Burazeri, G, Qirjako, G, Ylli, A, Cumashi, R, P Costantini-Olmos, A, Morr, I, Chuki, E, Wang, T, Chen, W, Lin, H, Malik, F, R Choudhury, S, Abdullah Al Mamun, M, Ishraquzzaman, M, S Aljuraiban, G, Y Al Slail, F, K Aldhwailea, S, A Badawi, A, L Viet, N, A Tien, H, Dong, N, T Sinh, C, V Minh, H, K Son, T, K Katamba, F, B Buila, N, Dzudie, A, Kingue, S, Epie, N, Njomou, A, S Ndom, M, M Yusufali, A, M Bazargani, N, Bin Belaila, B, Agrawal, A, M Suhail, A, N Ogola, E, M Gitura, B, Mbau, L, K Nguchu, H, A Barasa, F, Gomez, E, A Alcocer, L, Rosas, M, Palomo, S, J Estrada, A, Lopez-Jaramillo, P, Sanchez-Vallejo, G, E Casanova, M, Arcos, E, Aroca, G, Koirala, B, Bhattarai, H, Pandey, G, Devkota, S, Koirala, S, Ranabhat, K, Khanal, P, B Adhikari, T, D Bonzon, D, D Ona, D, M Asis, L, A Balmores Jr, B, C Castillo, R, J Stisman, D, G Espeche, W, J Marin, M, L Ennis, I, Chen, X, Wang, H, Liu, M, Yin, X, Wang, X, Bhalla, S, Gupta, P, Verma, N, K Gupta, B, Sheikh, S, Wuerzner, G, Garré, L, Boggia, J, M Houenassi, D, A OctavioSeijas, J, M'buyamba-Kabangu, J, M Tshiswaka, T, Páll, D, Járai, Z, Hernández, R, Garcia Vásquez, F, A Lopez-Rivera, J, L Gúzman-Franolic, M, Victoria Pereira, S, J Fernandes, M, S Garcia, M, Gijon, T, Meira Da Cunha, V, and RS: CARIM other
Subjects: Male, Population level, Comorbidity, 030204 cardiovascular system & hematology, 0302 clinical medicine, Prevalence, adults, Medicine, Mass Screening, awareness, 030212 general & internal medicine, 1102 Cardiorespiratory Medicine and Haematology, Aged, 80 and over, Aspirin, treatment, adults, awareness, blood pressure, hypertension, risk factor, screening, treatment, blood pressure, Middle Aged, Lifestyle factors, risk factor, Female, Life Sciences & Biomedicine, medicine.drug, Adult, medicine.medical_specialty, hypertension, Adolescent, awarene, Opportunistic Sampling, Elevated blood, 1117 Public Health and Health Services, 03 medical and health sciences, Young Adult, Internal Medicine, Humans, Risk factor, Antihypertensive Agents, Aged, Science & Technology, business.industry, screening, Blood Pressure Determination, 1103 Clinical Sciences, Mean blood pressure, Blood pressure, Peripheral Vascular Disease, Cardiovascular System & Hematology, Emergency medicine, Cardiovascular System & Cardiology, business, MMM Investigators
Abstract: Elevated blood pressure remains the single biggest risk factor contributing to the global burden of disease and mortality. May Measurement Month is an annual global screening campaign aiming to improve awareness of blood pressure at the individual and population level. Adults ({greater than or equal to}18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally three blood pressure readings were measured for each participant, and data on lifestyle factors and co-morbidities were collected. Hypertension was defined as a systolic BP {greater than or equal to} 140 mmHg, and/or a diastolic BP {greater than or equal to} 90 mmHg (mean of the second and third readings) or taking antihypertensive medication. When necessary, multiple imputation was used to estimate participants' mean blood pressure. Mixed-effects models were used to evaluate associations between blood pressure and participant characteristics. Of 1,508,130 screenees 482,273 (32.0%) had never had a blood pressure measurement before and 513,337 (34.0%) had hypertension, of whom 58.7% were aware and 54.7% were on antihypertensive medication. Of those on medication, 57.8% were controlled to
Published: 2020
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33. 24-HOUR CENTRAL BLOOD PRESSURE

Author: Robert Zweiker, Piotr Jankowski, Ian B. Wilkinson, Charalambos Vlachopoulos, Antonis Argyris, Andréa Araujo Brandão, Lisa J. Ware, A. Machado Gomes, José R. Banegas, M.L. Muiesan, János Nemcsik, Jacques Blacher, C. M. McEniery, Sola Aoun Bahous, Siegfried Wassertheurer, Enrique Rodilla, Mota Gomes, Mohsen Agharazii, Dimitrios Terentes-Printzios, Alexandre Vallée, Aletta E. Schutte, James E. Sharman, B. McDonnel, Cristina Giannattasio, Thomas Weber, Juan J. de la Cruz, Athanase D. Protogerou, Alessandro Maloberti, You Li, Auxiliadora Graciani, Weber, T, Protogerou, A, Wassertheurer, S, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Blacher, J, Brandao, A, Cruz, J, Giannattasio, C, Jankowski, P, Li, Y, Maloberti, A, Mcdonnel, B, Mceniery, C, Mota Gomes, M, Machado Gomes, A, Graciani, A, Muiesan, M, Nemcsik, J, Rodilla, E, Schutte, A, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman., J, 10922180 - Schutte, Aletta Elisabeth, and 24398330 - Ware, Lisa Jayne
Subjects: medicine.medical_specialty, Physiology, business.industry, 24-hour central blood pressure, reference values, Blood pressure, Central blood pressure, Reference values, Internal medicine, Healthy individuals, Ambulatory, Internal Medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: Objective: Central systolic blood pressure (cSBP) differs from peripheral SBP (pSBP) and may have higher prognostic relevance, but the normal values in ambulatory conditions are unknown. We present reference values for 24-hour central BP profiles, obtained in apparently healthy adult individuals from 20 centers in 14 countries and 5 continents, and compare the findings with peripheral BP. Design and method: 24-hour ambulatory BP monitoring, using a validated oscillometric device (Mobilograph, I.E.M, Stolberg, Germany), was performed in 2527 individuals (1206 men, 1321 women). Central pressures were assessed, using brachial waveforms, calibrated with mean/diastolic BP, and a transfer function. Participants were divided into 6 age groups (18–29, 30–39, 40–49, 50–59, 60–69, 70–99 years). Nighttime/daytime difference (N/D) was defined as nighttime (01.00 - 06.00) minus daytime (09.00 - 21.00) values / daytime values. Results: Averaged 24-hour central BP across all individuals was 128/79 mm Hg (daytime 128/81 mm Hg, nighttime 125/72 mm Hg), with slightly higher BP in men, compared to women. In contrast, central pulse pressure (PP; mean value 48 mm Hg, daytime 46 mm Hg, nighttime 52 mm Hg) was higher in women, compared to men. Mean values for cSBP, diastolic BP, and heart rate were highest in middle age, whereas mean values for cPP were highest in old age. Peripheral SBP N/D was −11% in the youngest age group, and decreased with increasing age, reaching −6% in the oldest age group. In contrast, cSBP N/D was less pronounced, even inverse (1 %) in the youngest age group, reaching −2 % in the oldest age group. Peripheral PP N/D was negligible across all age groups, and central PP N/D was inverse and highest (31 %) in the youngest age group. Conclusions: We provide reference values for apparently healthy individuals across the adult life span for central SBP and PP, comprising 24-hour mean BPs and 24-hour variability. Both differ from peripheral BP. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management
Published: 2019
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34. Relationship Between 24-Hour Ambulatory Central Systolic Blood Pressure and Left Ventricular Mass A Prospective Multicenter Study

Author: Jörg Kellermair, Ian B. Wilkinson, Claudia Mang, Anna Paini, Carmel M. McEniery, Jose Maria Pascual, Massimo Salvetti, Thomas Weber, Danuta Czarnecka, Bernhard Hametner, Maria Lorenza Muiesan, Siegfried Wassertheurer, Enrique Rodilla, Piotr Jankowski, Cornelia Ablasser, Alessandro Maloberti, Robert Zweiker, Cristina Giannattasio, Arno Schmidt-Trucksäss, Weber, T, Wassertheurer, S, Schmidt trucksäss, A, Rodilla, E, Ablasser, C, Jankowski, P, Lorenza Muiesan, M, Giannattasio, C, Mang, C, Wilkinson, I, Kellermair, J, Hametner, B, Pascual, J, Zweiker, R, Czarnecka, D, Paini, A, Salvetti, M, Maloberti, A, and Mceniery, C
Subjects: Male, Brachial Artery, blood pressure, blood pressure monitoring, ambulatory, echocardiography, hypertrophy, left ventricular, multicenter study, Adolescent, Adult, Aged, Aged, 80 and over, Arterial Pressure, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Circadian Rhythm, Echocardiography, Female, Follow-Up Studies, Heart Ventricles, Humans, Hypertrophy, Left Ventricular, Middle Aged, Prospective Studies, Systole, Young Adult, Internal Medicine, ambulatory, 030204 cardiovascular system & hematology, Left ventricular hypertrophy, Muscle hypertrophy, 0302 clinical medicine, Blood Pressure Monitoring, 80 and over, 030212 general & internal medicine, Left Ventricular, Ambulatory, Cuff, cardiovascular system, Cardiology, medicine.medical_specialty, Left ventricular mass, 03 medical and health sciences, Internal medicine, medicine, cardiovascular diseases, business.industry, Mean age, Hypertrophy, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, medicine.disease, Blood pressure, Multicenter study, business
Abstract: We investigated the relationship between left ventricular mass and brachial office as well as brachial and central ambulatory systolic blood pressure in 7 European centers. Central systolic pressure was measured with a validated oscillometric device, using a transfer function, and mean/diastolic pressure calibration. M-mode images were obtained by echocardiography, and left ventricular mass was determined by one single reader blinded to blood pressure. We studied 289 participants (137 women) free from antihypertensive drugs (mean age: 50.8 years). Mean office blood pressure was 145/88 mm Hg and mean brachial and central ambulatory systolic pressures were 127 and 128 mm Hg, respectively. Mean left ventricular mass was 93.3 kg/m 2 , and 25.6% had left ventricular hypertrophy. The correlation coefficient between left ventricular mass and brachial office, brachial ambulatory, and central ambulatory systolic pressure was 0.29, 0.41, and 0.47, respectively ( P =0.003 for comparison between brachial office and central ambulatory systolic pressure and 0.32 for comparison between brachial and central ambulatory systolic pressure). The results were consistent for men and women, and young and old participants. The areas under the curve for prediction of left ventricular hypertrophy were 0.618, 0.635, and 0.666 for brachial office, brachial, and central ambulatory systolic pressure, respectively ( P =0.03 for comparison between brachial and central ambulatory systolic pressure). In younger participants, central ambulatory systolic pressure was superior to both other measurements. Central ambulatory systolic pressure, measured with an oscillometric cuff, shows a strong trend toward a closer association with left ventricular mass and hypertrophy than brachial office/ambulatory systolic pressure. Clinical Trial Registration— URL: https://www.clinicaltrials.gov . Unique identifier: NCT01278732.
Published: 2017

35. [Documento de consenso de la Sociedad Española de Obstetricia y Ginecologia (SEGO) y el Comité Español Interdisciplinario para la Prevención Vascular (CEIPV). Ventana de oportunidad: prevención del riesgo vascular en la mujer. Resultados adversos del embarazo y riesgo de enfermedad vascular.]

Author: Goya M, Miserachs M, Suy Franch A, Burgos J, de la Calle M, Brotons C, Castellanos M, Cortés Rico O, Díaz Rodriguez Á, Elosúa R, Freijo MDM, González Fondado M, Gorostidi M, Grau M, Hernández Martínez AM, Lahoz C, Muñoz-Rivas N, Pallares-Carratalá V, Pedro-Botet J, Rodilla E, Goya E, Royo Bordonada MÁ, Santamaría R, Torres Fonseca M, Velescu A, Zamora A, and Armario P
Subjects: Humans, Pregnancy, Female, Infant, Newborn, Placenta, Spain, Fetal Growth Retardation, Retrospective Studies, Premature Birth, Hypertension drug therapy
Abstract: This document summarises the evidence regarding the association between adverse pregnancy outcomes (APOs), such as hypertensive disorders, preterm birth, gestational diabetes, fetal growth defects (small for gestational age and/or fetal growth restriction), placental abruption, fetal loss, and the risk that a pregnant individual in developing vascular risk factors (VR) that may lead to future vascular disease (VD): coronary heart disease, stroke, peripheral vascular disease, and heart failure. Furthermore, this document emphasises the importance of recognising APOs when assessing VR in women. A history of APOs serves as a sufficient indicator for primary prevention of VD. In fact, adopting a healthy diet and increasing physical activity among women with APOs, starting during pregnancy and/or postpartum, and maintaining it throughout life are significant interventions that can reduce VR. On the other hand, breastfeeding can also reduce the future VR of women, including a lower risk of mortality. Future studies evaluating the use of aspirin, statins, and metformin, among others, in women with a history of APOs could strengthen recommendations regarding pharmacotherapy for primary prevention of VD in these patients. Various healthcare system options exist to improve the transition of care for women with APOs between different healthcare professionals and implement long-term VR reduction strategies. One potential process could involve incorporating the fourth-trimester concept into clinical recommendations and healthcare policies.
Published: 2023

36. Management of Patients with Suspected or Confirmed Antibiotic Allergy: Executive Summary of Guidelines from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Allergy and Clinical Immunology (SEAIC), the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Intensive Medicine and Coronary Care Units (SEMICYUC).

Author: Paño-Pardo JR, Moreno Rodilla E, Cobo Sacristan S, Cubero Saldaña JL, Periañez Párraga L, Del Pozo León JL, Retamar-Gentil P, Rodríguez Oviedo A, Torres Jaén MJ, Vidal-Cortes P, and Colás Sanz C
Subjects: Humans, Coronary Care Units, Anti-Bacterial Agents adverse effects, Pharmacy Service, Hospital, Communicable Diseases drug therapy, Drug Hypersensitivity therapy, Drug Hypersensitivity drug therapy, Hypersensitivity drug therapy
Abstract: Suspected or confirmed antibiotic allergy is a frequent clinical circumstance that influences antimicrobial prescription and often leads to the avoidable use of less efficacious and/or more toxic or costly drugs than first-line antimicrobials. Optimizing antimicrobial therapy in patients with antibiotic allergy labels has become one of the priorities of antimicrobial stewardship programs in several countries. These guidelines aim to make recommendations for the systematic approach to patients with suspected or confirmed antibiotic allergy based on current evidence. An expert panel (11 members of various scientific societies) formulated questions about the management of patients with suspected or confirmed antibiotic allergy. A systematic literature review was performed by a medical librarian. The questions were distributed among panel members who selected the most relevant references, summarized the evidence, and formulated graded recommendations when possible. The answers to all the questions were finally reviewed by all panel members. A systematic approach to patients with suspected or confirmed antibiotic allergy was recommended to improve antibiotic selection and, consequently, clinical outcomes. A clinically oriented, 3-category risk-stratification strategy was recommended for patients with suspected antibiotic allergy. Complementary assessments should consider both clinical risk category and preferred antibiotic agent. Empirical therapy recommendations for the most relevant clinical syndromes in patients with suspected or confirmed ß-lactam allergy were formulated, as were recommendations on the implementation and monitoring of the impact of the guidelines. Antimicrobial stewardship programs and allergists should design and implement activities that facilitate the most appropriate use of antibiotics in these patients.
Published: 2023
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37. How the Presence of a Doctor Known to Patients Impacts a Web-Based Intervention to Promote Physical Activity and Healthy Eating Behaviour in Individuals with an Overweight/Obesity-Hypertension Phenotype: A Randomised Clinical Trial.

Author: Ruiz-Cortés M, Múzquiz-Barberá P, Herrero R, Vara MD, Escrivá-Martínez T, Carcelén R, Rodilla E, Baños RM, and Lisón JF
Subjects: Humans, Overweight psychology, Obesity, Exercise, Feeding Behavior, Internet-Based Intervention, Hypertension
Abstract: (1) Background: The 'Living Better' web-based programme has shown short- and long-term benefits for body composition and psychological variables in obese patients with hypertension by promoting a healthier lifestyle. To further explore the potential of this programme, in this work we aimed to explore the possible effect of the patient's 'own doctor' appearing in the video content of the Living Better intervention. (2) Methods: A total of 132 patients were randomly assigned either to the experimental (EG, n = 70) or control (CG, n = 62) group (with a doctor the patient knew as 'their own' or an 'unknown doctor', respectively). The body mass index (BMI), motivation towards physical activity (PA), PA levels, motivation to change one's eating habits, adherence to the Mediterranean diet, and eating behaviour were all assessed and compared at baseline and post-intervention (12 weeks). (3) Results: The results of this study confirmed the positive effects of the Living Better programme on BMI and external eating style, with significant improvements in these variables in both groups. In addition, in the EG there was higher intrinsic motivation to change eating behaviour (mean difference of 0.9, 95% CI [0.1, 1.6], p = 0.032) and lower amotivation (mean difference of -0.6, 95% CI [-1.2, -0.1], p = 0.027) compared to the CG. (4) Conclusions: This study suggests that the presence of the patients' own doctor in the audiovisual content of the Living Better intervention did not have significant additional benefits in terms of BMI or external eating style. However, their presence did improve intrinsic motivation and amotivation related to eating habits.
Published: 2023
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38. "Own doctor" presence in a web-based lifestyle intervention for adults with obesity and hypertension: A randomized controlled trial.

Author: Múzquiz-Barberá P, Ruiz-Cortés M, Herrero R, Vara MD, Escrivá-Martínez T, Baños RM, Rodilla E, and Lisón JF
Subjects: Humans, Adult, Quality of Life, Obesity therapy, Life Style, Internet-Based Intervention, Hypertension therapy
Abstract: Introduction: Online interventions have long been shown to be an effective means to promote a healthy lifestyle, thereby helping to control body weight and blood pressure figures. Likewise, using video modeling is also considered an effective way to guide patients through behavioral interventions. Nonetheless, to the best of our knowledge, this study is the first to analyze how the presence of patients' "own doctor" in the audiovisual content of a web-based lifestyle program (" Living Better" ) aimed at promoting regular physical exercise and healthy eating behavior, compared with an "unknown doctor," influences the outcomes of adults with obesity and hypertension., Materials and Methods: A total of 132 patients were randomly assigned either to the experimental ( n = 70) or control ( n = 62) group ("own doctor" or "unknown doctor", respectively). The body mass index, systolic and diastolic blood pressure, number of antihypertensive drugs used, physical activity level, and quality of life was assessed and compared at baseline and post-intervention (12 weeks)., Results: The intention-to-treat analysis showed intragroup significant improvements in both groups in terms of the body mass index (control group: mean difference -0.3, 95% CI [-0.5, -0.1], p = 0.002; experimental group: -0.4 [-0.6, -0.2], p < 0.001) and systolic blood pressure (control group: -2.3 [-4.4, -0.2], p = 0.029; experimental group: -3.6 [-5.5, -1.6], p < 0.001). In addition, there were also significant improvements in the experimental group for the diastolic blood pressure (-2.5 [-3.7, -1.2], p < 0.001), physical activity (479 [9, 949], p = 0.046), and quality of life (5.2 [2.3, 8.2], p = 0.001). However, when comparing the experimental with the control group, no between-group significant differences were found in these variables., Conclusions: This study suggests that the presence of patients' "own doctor" in the audiovisual content of a web-based intervention, aimed at promoting a healthy lifestyle among adults with obesity and hypertension, do not show significant additional benefits over the efficacy of e-counseling., Trial Registration: ClinicalTrials.gov NCT04426877. First Posted: 11/06/2020. https://clinicaltrials.gov/ct2/show/NCT04426877., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Múzquiz-Barberá, Ruiz-Cortés, Herrero, Vara, Escrivá-Martínez, Baños, Rodilla and Lisón.)
Published: 2023
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39. Changes in Sensitization Patterns in the Last 25 Years in 619 Patients with Confirmed Diagnoses of Immediate Hypersensitivity Reactions to Beta-Lactams.

Author: Campanón Toro MDV, Moreno Rodilla E, Gallardo Higueras A, Laffond Yges E, Muñoz Bellido FJ, Gracia Bara MT, Martin García C, Moreno Rodilla V, Macías Iglesias EM, Arriba Méndez S, Sobrino García M, and Dávila I
Abstract: Beta-lactam (BL) drugs are the antibiotics most prescribed worldwide due to their broad spectrum of action. They are also the most frequently implied in hypersensitivity reactions with a known specific immunological mechanism. Since the commercialization of benzylpenicillin, allergic reactions have been described; over the years, other new BL drugs provided alternative treatments to penicillin, and amoxicillin is now the most prescribed BL in Europe. Diagnosis of BL allergy is mainly based on skin tests and drug provocation tests, defining different sensitization patterns or phenotypes. In this study, we evaluated 619 patients with a confirmed diagnosis of BL-immediate allergy during the last 25 years, using the same diagnostic procedures with minor adaptations to the successive guidelines. The initial eliciting drug was benzylpenicillin, which changed to amoxicillin with or without clavulanic acid and cephalosporins in recent years. In skin tests, we found a decrease in sensitivity to major and minor penicillin determinants and an increase in sensitivity to amoxicillin and others; this might reflect that the changes in prescription could have influenced the sensitization patterns, thus increasing the incidence of specific reactions to side-chain selective reactions.
Published: 2022
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40. The Impact of a Web-Based Lifestyle Educational Program ('Living Better') Reintervention on Hypertensive Overweight or Obese Patients.

Author: Múzquiz-Barberá P, Ruiz-Cortés M, Herrero R, Vara MD, Escrivá-Martínez T, Carcelén R, Baños RM, Rodilla E, and Lisón JF
Subjects: Body Mass Index, Humans, Internet, Life Style, Obesity epidemiology, Obesity therapy, Overweight epidemiology, Overweight therapy, Pandemics, COVID-19, Hypertension therapy
Abstract: ‘Living Better’, a self-administered web-based intervention, designed to facilitate lifestyle changes, has already shown positive short- and medium-term health benefits in patients with an obesity−hypertension phenotype. The objectives of this study were: (1) to examine the long-term (3-year) evolution of a group of hypertensive overweight or obese patients who had already followed the ‘Living Better’ program; (2) to analyze the effects of completing this program a second time (reintervention) during the COVID-19 pandemic. A quasi-experimental design was used. We recruited 29 individuals from the 105 who had participated in our first study. We assessed and compared their systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI), eating behavior, and physical activity (PA) level (reported as METs-min/week), at Time 0 (first intervention follow-up), Time 1 (before the reintervention), and Time 2 (post-reintervention). Our results showed significant improvements between Time 1 and Time 2 in SBP (−4.7 (−8.7 to −0.7); p = 0.017), DBP (−3.5 (−6.2 to −0.8); p = 0.009), BMI (−0.7 (−1.0 to −0.4); p < 0.001), emotional eating (−2.8 (−5.1 to −0.5); p = 0.012), external eating (−1.1 (−2.1 to −0.1); p = 0.039), and PA (Time 1: 2308 ± 2266; Time 2: 3203 ± 3314; p = 0.030, Z = −2.17). Statistical analysis showed no significant differences in SPB, DBP, BMI, and eating behavior between Time 0 and Time 1 (p > 0.24). Implementation of the ‘Living Better’ program maintained positive long-term (3-year) health benefits in patients with an obesity−hypertension phenotype. Moreover, a reintervention with this program during the COVID-19 pandemic produced significant improvements in blood pressure, BMI, eating behavior, and PA.
Published: 2022
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41. Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals.

Author: Weber T, Protogerou AD, Agharazii M, Argyris A, Aoun Bahous S, Banegas JR, Binder RK, Blacher J, Araujo Brandao A, Cruz JJ, Danninger K, Giannatasio C, Graciani A, Hametner B, Jankowski P, Li Y, Maloberti A, Mayer CC, McDonnell BJ, McEniery CM, Antonio Mota Gomes M, Machado Gomes A, Lorenza Muiesan M, Nemcsik J, Paini A, Rodilla E, Schutte AE, Sfikakis PP, Terentes-Printzios D, Vallée A, Vlachopoulos C, Ware L, Wilkinson I, Zweiker R, Sharman JE, and Wassertheurer S
Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Arterial Pressure physiology, Blood Pressure Determination, Brachial Artery physiology, Female, Humans, Male, Middle Aged, Reference Values, Young Adult, Blood Pressure physiology, Circadian Rhythm physiology
Abstract: Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18-94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBP MAP/DBPcal ), or bSBP/diastolic blood pressure (cSBP SBP/DBPcal ), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBP MAP/DBPcal were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBP SBP/DBPcal , respectively. We pragmatically propose as upper normal limit for 24-hour cSBP MAP/DBPcal 135 mm Hg and for 24-hour cSBP SBP/DBPcal 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was -10.6 % in young participants and decreased with increasing age. Central SBP SBP/DBPcal dipping was less pronounced (-8.7% in young participants). In contrast, cSBP MAP/DBPcal dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation.
Published: 2022
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42. May Measurement Month 2019: an analysis of blood pressure screening results from Spain.

Author: Molinero A, Calvo E, Beaney T, Day E, Prats-Mas R, Fornos JA, Mera-Gallego I, Tous S, de Andrés NF, Rodilla E, Gijón T, Pérez-Manchon D, Poulter NR, Ruiz-Hurtado G, and Ruilope LM
Abstract: The aim of the May Measurement Month (MMM) is devoted to better understanding the awareness, treatment, and control rates of hypertension in Spain. Presented here are the data corresponding to 2019 campaign. In 2019, a total of 4433 patients (61.5% males) with a mean age of 54.8 years were included. Of all, 96.0% were Caucasian, and 3294 were recruited in pharmacies. The mean values of systolic blood pressure (BP) were 125.6 and of diastolic 76.7 mmHg in the whole population. The most recent previous BP measurement took place more than 1 year before in 27.6% of participants. A total of 1883 were hypertensive (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg or taking antihypertensive medication), of whom 77.2%/were aware and 71.1% were on medication. Of all, 64.9% of those on medication and 46.1% of all hypertensive participants had a BP controlled to <140/90 mmHg. These data from MMM 2019 continue to indicate the need for an improvement in the awareness, treatment, and control of hypertension in Spain., (Published on behalf of the European Society of Cardiology. © The Author(s) 2021.)
Published: 2021
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43. Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain.

Author: Rodilla E, López-Carmona MD, Cortes X, Cobos-Palacios L, Canales S, Sáez MC, Campos Escudero S, Rubio-Rivas M, Díez Manglano J, Freire Castro SJ, Vázquez Piqueras N, Mateo Sanchis E, Pesqueira Fontan PM, Magallanes Gamboa JO, González García A, Madrid Romero V, Tamargo Chamorro L, González Moraleja J, Villanueva Martínez J, González Noya A, Suárez-Lombraña A, Gracia Gutiérrez A, López Reboiro ML, Ramos Rincón JM, and Gómez Huelgas R
Subjects: Age Factors, Aged, Aged, 80 and over, Blood Pressure, COVID-19 mortality, Cardiovascular Diseases epidemiology, Cause of Death, Comorbidity, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Obesity epidemiology, Odds Ratio, Prognosis, Pulmonary Disease, Chronic Obstructive epidemiology, Registries, Retrospective Studies, Spain epidemiology, COVID-19 epidemiology, Hospital Mortality, Hypertension epidemiology, Pandemics, SARS-CoV-2, Vascular Stiffness
Abstract: Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P <0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P =0.0001; ORadj: 1.48, P =0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P =0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P =0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P =0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization.
Published: 2021
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44. Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19.

Author: Rodilla E, Saura A, Jiménez I, Mendizábal A, Pineda-Cantero A, Lorenzo-Hernández E, Fidalgo-Montero MDP, López-Cuervo JF, Gil-Sánchez R, Rabadán-Pejenaute E, Abella-Vázquez L, Giner-Galvañ V, Solís-Marquínez MN, Boixeda R, Peña-Fernández A, Carrasco-Sánchez FJ, González-Moraleja J, Torres-Peña JD, Guisado-Espartero ME, Escobar-Sevilla J, Guzmán-García M, Martín-Escalante MD, Martínez-González ÁL, Casas-Rojo JM, and Gómez-Huelgas R
Abstract: It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ± 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs.
Published: 2020
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45. May Measurement Month 2018: an analysis of blood pressure screening results from Spain.

Author: Rodilla E, Molinero A, Gijón-Conde T, Tous S, Fornós JA, Mera I, Martínez F, Carreras B, de Berardinis B, Beaney T, Ster AC, Poulter NR, Xia X, and Ruilope LM
Abstract: Elevated blood pressure (BP) is the single most important contributing risk factor to the global disease burden, leading to over 10 million deaths each year. In Spain, hypertension (HTN) affects around 20% of the adult population and remains the greatest attributable cause of cardiovascular mortality. May Measurement Month (MMM) is a worldwide initiative aimed at increasing awareness of HTN and to improve the lack of screening programmes worldwide. An opportunistic cross-sectional survey of volunteers aged 18 and over was carried out in May 2018. Blood pressure measurement, the definition of HTN and statistical analysis followed the standard MMM protocol. Anthropometric data and responses to questionnaires on demographic, lifestyle, and environmental factors were obtained as additional information. Screening sites mainly in community pharmacies, universities, primary care centres, HTN units, and cardiovascular departments in hospitals were set up across Spain as part of this initiative. In total, 7646 individuals (63.5% female) were screened during MMM18. After multiple imputation, 40.0% had HTN, of whom 74.4% were aware of their diagnosis and 69.6% were taking antihypertensive medication. Of individuals not receiving antihypertensive medication, 16.9% were hypertensive. Of individuals receiving antihypertensive medication, 36.4% had uncontrolled BP. MMM18 almost doubled the number of participants of MMM17 and was the largest BP screening campaign ever undertaken in Spain, showing that in the absence of systematic screening programmes for HTN, MMM can identify a great number of individuals at risk, increasing their awareness and attracting the interest of the healthcare system in Spain., (Published on behalf of the European Society of Cardiology. © The Author(s) 2020.)
Published: 2020
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46. Impact of a Web-Based Exercise and Nutritional Education Intervention in Patients Who Are Obese With Hypertension: Randomized Wait-List Controlled Trial.

Author: Lisón JF, Palomar G, Mensorio MS, Baños RM, Cebolla-Martí A, Botella C, Benavent-Caballer V, and Rodilla E
Subjects: Adolescent, Adult, Aged, Female, Humans, Internet, Male, Middle Aged, Prospective Studies, Waiting Lists, Young Adult, Exercise physiology, Health Education methods, Hypertension therapy, Nutrition Assessment, Obesity therapy
Abstract: Background: Internet-based interventions are a promising strategy for promoting healthy lifestyle behaviors. These have a tremendous potential for delivering electronic health interventions in scalable and cost-effective ways. There is strong evidence that the use of these programs can lead to weight loss and can lower patients' average blood pressure (BP) levels. So far, few studies have investigated the effects of internet-based programs on patients who are obese with hypertension (HTN)., Objective: The aim of this study is to investigate the short- and long-term efficacy, in terms of body composition and BP parameters, of a self-administered internet-based intervention involving different modules and learning techniques aimed at promoting lifestyle changes (both physical activity and healthy eating) in patients who are obese with HTN., Methods: A randomized wait-list controlled trial design was used. We recruited 105 adults with HTN who were overweight or obese and randomly assigned them to either a 3-month internet-based intervention group (n=55) or the wait-list control group (n=50). We assessed BMI (primary outcome), body fat mass (BFM), systolic (S)BP and diastolic (D)BP, blood glucose and insulin levels, physical activity levels, and functional capacity for aerobic exercise at Time 0 (preintervention) and Time 1 (postintervention). All the patients in the wait-list control group subsequently received the intervention, and a secondary within-group analysis, which also included these participants, was conducted at Time 2 (12-month follow-up)., Results: A 2-way mixed analysis of covariance showed a significant decrease in BMI, BFM, and blood glucose at 3 months in the internet-based intervention group; the effect size for the BMI and BFM parameters was moderate to large, and there was also a borderline significant trend for DBP and insulin. These results were either maintained or improved upon at Time 2 and showed significant changes for BMI (mean difference -0.4, 95% CI -0.1 to -0.6; P=.005), BFM (mean difference -2.4, 95% CI -1.1 to -3.6; P<.001), DBP (mean difference -1.8, 95% CI -0.2 to -3.3; P=.03), and blood glucose (mean difference -2, 95% CI 0 to -4; P=.04)., Conclusions: Implementation of our self-administered internet-based intervention, which involved different learning techniques aimed to promote lifestyle changes, resulted in positive short- and long-term health benefits in patients who are obese with HTN., Trial Registration: ClinicalTrials.gov NCT03396302; https://clinicaltrials.gov/ct2/show/NCT03396302., (©Juan Francisco Lisón, Gonzalo Palomar, Marinna S Mensorio, Rosa M Baños, Ausiàs Cebolla-Martí, Cristina Botella, Vicent Benavent-Caballer, Enrique Rodilla. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 14.04.2020.)
Published: 2020
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47. May Measurement Month 2017: an analysis of blood pressure screening in Spain-Europe.

Author: Molinero A, Ruilope LM, Tous S, Fornos JA, Mera I, Andrés NF, Iracheta M, Xia X, Beaney T, Poulter NR, Rodilla E, Martínez F, and Gijón-Conde T
Abstract: May Measurement Month 2017 is a global initiative aimed at raising awareness of high blood pressure (BP) and to act as a temporary solution to the lack of screening programs worldwide, in which Spain participated actively. The primary objective was to raise awareness and increase control of BP in Spain. An opportunistic cross-sectional survey of volunteers aged ≥18 was set up in May 2017. Following the design of the International Society of Hypertension, data were collected from the 17 autonomous communities in which Spain is divided, mainly in community pharmacies, primary care centres and some hypertension (HT) units, and cardiovascular departments in hospitals. No additional training of volunteers was necessary. A total of 3849 individuals were screened. After multiple imputation, our data showed that 1923 (50.0%) had HT. In those not receiving antihypertensive medication, 17.5% were hypertensives, in individuals receiving antihypertensive medication, 33.9% had uncontrolled BP. May Measurement Month 2017 was the largest BP screening campaign undertaken in Spain. In total, 17.5% of people with HT did not receive medication. One-third of hypertensive participants receiving treatment did not have their BP controlled. These results confirm that an opportunistic screening can identify a significant number of subjects with and untreated and inadequately treated BP.
Published: 2019
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48. Effect of physical activity on pulse wave velocity in elderly subjects with normal glucose, prediabetes or Type 2 Diabetes.

Author: Metsämarttila E, Rodilla E, Jokelainen J, Herrala S, Leppäluoto J, Keinänen-Kiukaanniemi S, and Herzig KH
Subjects: Aged, Blood Flow Velocity, Cardiovascular Diseases etiology, Cardiovascular Diseases pathology, Case-Control Studies, Cohort Studies, Diabetes Mellitus, Type 2 physiopathology, Female, Humans, Male, Prediabetic State physiopathology, Risk Factors, Blood Glucose metabolism, Cardiovascular Diseases prevention & control, Diabetes Mellitus, Type 2 complications, Exercise Therapy, Prediabetic State complications, Pulse Wave Analysis, Vascular Stiffness
Abstract: Carotid-femoral pulse wave velocity ((cf)PWV) is a measure of arterial stiffness, predicting cardiovascular disease. We hypothesized that the amount of physical activity (PA) is correlated with reduced arterial stiffness in Type 2 diabetic (T2D) subjects. 570 subjects from the 1945 Oulu birth cohort were included in the analysis. (cf)PWV was determined by a non-invasive applanation tonometry. Oral glucose tolerance test was performed and LDL and HDL cholesterol analyzed. PA was registered daily with a wrist-worn acceleration meter for two weeks. (cf)PWV values in subjects with impaired glucose metabolism (IGM) and T2D were higher than in normal glycemic subjects (P < 0.001). PA, fasting and 2 h glucose and HbA1c correlated significantly with (cf)PWV, but HDL or LDL cholesterol did not. The 2 h glucose, heart rate and alcohol consumption in T2D subjects had independent effects on (cf)PWV in multiple regression analysis. T2D and IGM were significantly associated to (cf)PWV. Interestingly, lipids did not have an additional effect on (cf)PWV. Subjects walking more than 10 000 steps/day had 0.2 m/s lower (cf)PWV than those walking less than 6000 steps/day. Presence of T2D, elevated heart rate and alcohol consumption in males were associated with increased aortic stiffening in elderly subjects.
Published: 2018
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49. Relationship Between 24-Hour Ambulatory Central Systolic Blood Pressure and Left Ventricular Mass: A Prospective Multicenter Study.

Author: Weber T, Wassertheurer S, Schmidt-Trucksäss A, Rodilla E, Ablasser C, Jankowski P, Lorenza Muiesan M, Giannattasio C, Mang C, Wilkinson I, Kellermair J, Hametner B, Pascual JM, Zweiker R, Czarnecka D, Paini A, Salvetti M, Maloberti A, and McEniery C
Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Blood Pressure Monitoring, Ambulatory methods, Brachial Artery, Echocardiography, Female, Follow-Up Studies, Heart Ventricles physiopathology, Humans, Hypertrophy, Left Ventricular diagnosis, Male, Middle Aged, Prospective Studies, Systole, Young Adult, Arterial Pressure physiology, Blood Pressure physiology, Circadian Rhythm physiology, Heart Ventricles diagnostic imaging, Hypertrophy, Left Ventricular physiopathology
Abstract: We investigated the relationship between left ventricular mass and brachial office as well as brachial and central ambulatory systolic blood pressure in 7 European centers. Central systolic pressure was measured with a validated oscillometric device, using a transfer function, and mean/diastolic pressure calibration. M-mode images were obtained by echocardiography, and left ventricular mass was determined by one single reader blinded to blood pressure. We studied 289 participants (137 women) free from antihypertensive drugs (mean age: 50.8 years). Mean office blood pressure was 145/88 mm Hg and mean brachial and central ambulatory systolic pressures were 127 and 128 mm Hg, respectively. Mean left ventricular mass was 93.3 kg/m 2 , and 25.6% had left ventricular hypertrophy. The correlation coefficient between left ventricular mass and brachial office, brachial ambulatory, and central ambulatory systolic pressure was 0.29, 0.41, and 0.47, respectively ( P =0.003 for comparison between brachial office and central ambulatory systolic pressure and 0.32 for comparison between brachial and central ambulatory systolic pressure). The results were consistent for men and women, and young and old participants. The areas under the curve for prediction of left ventricular hypertrophy were 0.618, 0.635, and 0.666 for brachial office, brachial, and central ambulatory systolic pressure, respectively ( P =0.03 for comparison between brachial and central ambulatory systolic pressure). In younger participants, central ambulatory systolic pressure was superior to both other measurements. Central ambulatory systolic pressure, measured with an oscillometric cuff, shows a strong trend toward a closer association with left ventricular mass and hypertrophy than brachial office/ambulatory systolic pressure., Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01278732., (© 2017 American Heart Association, Inc.)
Published: 2017
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50. Prognostic value of microalbuminuria during antihypertensive treatment in essential hypertension.

Author: Pascual JM, Rodilla E, Costa JA, Garcia-Escrich M, Gonzalez C, and Redon J
Subjects: Aged, Albuminuria physiopathology, Albuminuria urine, Biomarkers blood, Biomarkers urine, Blood Pressure Determination, Creatinine blood, Essential Hypertension, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Hypertension complications, Hypertension physiopathology, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Albuminuria etiology, Antihypertensive Agents therapeutic use, Blood Pressure, Hypertension drug therapy
Abstract: Whether changes over time of urinary albumin excretion have prognostic value is a matter of discussion. The objective was to assess the prognostic value of changes in urinary albumin excretion over time in cardiovascular risk during antihypertensive treatment. Follow-up study of 2835 hypertensives in the absence of previous cardiovascular disease (mean age 55 years, 47% men, BP 138/80 mm Hg, 19.1% diabetics, and calibrated systemic coronary risk estimation 5 or >10.6%). Usual-care of antihypertensive treatment was implemented to maintain blood pressure<140/90 mm Hg. Urinary albumin excretion was assessed yearly, and the values were expressed as the creatinine ratio. Incidence of cardiovascular events, fatal and nonfatal, was recorded during the follow-up. During a median follow-up of 4.7 years (17 028 patients-year), 294 fatal and first nonfatal cardiovascular events were recorded (1.73 CVD per 100 patients/year). Independently of blood pressure, estimated glomerular filtration rate, level of cardiovascular risk, and antihypertensive treatment, microalbuminuria at baseline and at any time during the follow-up resulted in higher risk for events, hazard ratio (HR) 1.35 (95% confidence interval [CI], 1.08-1.79) and HR 1.49 (95% CI, 1.14-1.94), respectively. Likewise, development of microalbuminuria (HR 1.60; 95% CI, 1.04-2.46) or persistence from the beginning (1.53; 95% CI, 1.13-2.06) had a significantly higher rate of events than if remained normoalbuminuric (HR 1) or regress to normoalbuminuria (HR 1.37; 95% CI, 0.92-2.06) with an 18%, 18%, 8%, and 11% events, respectively, P<0.001. The study supports the value of urinary albumin excretion assessment as a prognostic factor for cardiovascular risk, but also opens the way to consider it as an intermediate objective in hypertension., (© 2014 American Heart Association, Inc.)
Published: 2014
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