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13 results on '"Ruggero, Katia"'

4. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Author

Peirs, Sofie, Matthijssens, Filip, Goossens, Steven, Van de Walle, Inge, Ruggero, Katia, de Bock, Charles E., Degryse, Sandrine, Canté-Barrett, Kirsten, Briot, Delphine, Clappier, Emmanuelle, Lammens, Tim, De Moerloose, Barbara, Benoit, Yves, Poppe, Bruce, Meijerink, Jules P., Cools, Jan, Soulier, Jean, Rabbitts, Terence H., Taghon, Tom, Speleman, Frank, and Van Vlierberghe, Pieter

Published
2014
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6. MicroRNA expression in HTLV-1 infection and pathogenesis

Author

Zanovello Paola, Corti Giorgio, De Bellis Gianluca, Guffanti Alessandro, Basso Katia, Corradin Alberto, Pise-Masison Cynthia A, Bortoluzzi Stefania, Biasiolo Marta, Ruggero Katia, D'Agostino Donna M, Bronte Vincenzo, and Ciminale Vincenzo

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2011
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8. A circulating miRNA assay as a first-line test for prostate cancer screening

Author

Sharova, Evgeniya, Grassi, Angela, Marcer, Anna, Ruggero, Katia, Pinto, Francesco, Bassi, Pierfrancesco, Zanovello, Paola, Zattoni, Filiberto, D'Agostino, Donna M., Iafrate, Massimo, Ciminale, Vincenzo, Bassi, Pierfrancesco (ORCID:0000-0002-4313-8427), Sharova, Evgeniya, Grassi, Angela, Marcer, Anna, Ruggero, Katia, Pinto, Francesco, Bassi, Pierfrancesco, Zanovello, Paola, Zattoni, Filiberto, D'Agostino, Donna M., Iafrate, Massimo, Ciminale, Vincenzo, and Bassi, Pierfrancesco (ORCID:0000-0002-4313-8427)

Abstract

Background:Prostate cancer (PCa) screening currently relies on prostate-specific antigen (PSA) testing and digital rectal examination. However, recent large-scale studies have questioned the long-term efficacy of these tests, and biomarkers that accurately identify PCa are needed.Methods:We analysed the levels of circulating microRNAs (miRNAs) in patients with elevated PSA who were diagnosed with either localised PCa (n=36) or benign prostatic hyperplasia (BPH, n=31) upon biopsy. Real-time RT-PCR with Taqman probes was used to measure plasma levels of miRNAs. To circumvent problems associated with circulating miRNA quantitation, we computed the expression ratios of upregulated and downregulated miRNAs.Results:The miR-106a/miR-130b and miR-106a/miR-223 ratios were significantly different between the biopsy-positive and BPH groups (P<0.0001), and yielded statistical power values that were >0.99. Both miRNA ratios were highly sensitive and more specific than PSA in discriminating localised PCa from BPH. Receiver operating characteristic curve analysis revealed area under curve values of 0.81 (miR-106a/miR-130b) and 0.77 (miR-106a/miR-223).Conclusions:Testing for circulating miR-106a/miR-130b and miR-106a/miR-223 ratios may reduce the costs and morbidity of unnecessary biopsies and is feasible for large-scale screening, as it requires measuring only three miRNAs.

Published
2016

9. A circulating miRNA assay as a first-line test for prostate cancer screening

Author

Sharova, Evgeniya, primary, Grassi, Angela, additional, Marcer, Anna, additional, Ruggero, Katia, additional, Pinto, Francesco, additional, Bassi, Pierfrancesco, additional, Zanovello, Paola, additional, Zattoni, Filiberto, additional, D'Agostino, Donna M, additional, Iafrate, Massimo, additional, and Ciminale, Vincenzo, additional

Published
2016
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11. Small Noncoding RNAs in Cells Transformed by Human T-Cell Leukemia Virus Type 1: a Role for a tRNA Fragment as a Primer for Reverse Transcriptase

Author

Ruggero, Katia, primary, Guffanti, Alessandro, additional, Corradin, Alberto, additional, Sharma, Varun Kumar, additional, De Bellis, Gianluca, additional, Corti, Giorgio, additional, Grassi, Angela, additional, Zanovello, Paola, additional, Bronte, Vincenzo, additional, Ciminale, Vincenzo, additional, and D'Agostino, Donna M., additional

Published
2014
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12. MicroRNA expression in HTLV-1 infection and pathogenesis

Author

D'Agostino, Donna M, primary, Ruggero, Katia, additional, Biasiolo, Marta, additional, Bortoluzzi, Stefania, additional, Pise-Masison, Cynthia A, additional, Corradin, Alberto, additional, Basso, Katia, additional, Guffanti, Alessandro, additional, De Bellis, Gianluca, additional, Corti, Giorgio, additional, Zanovello, Paola, additional, Bronte, Vincenzo, additional, and Ciminale, Vincenzo, additional

Published
2011
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13. Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150.

Author

Margherita Ghisi, Alberto Corradin, Katia Basso, Chiara Frasson, Valentina Serafin, Subhamoy Mukherjee, Mussolin, Lara, Ruggero, Katia, Bonanno, Laura, Guffanti, Alessandro, de Bellis, Gianluca, Gerosa, Gino, Stellin, Giovanni, D'Agostino, Donna M., Basso, Giuseppe, Bronte, Vincenzo, Indraccolo, Stefano, Amadori, Alberto, and Zanovello, Paola

Subjects
*T-cell receptor genes, *ONTOGENY, *THYMUS, *CELL physiology, *CELL differentiation
Abstract

Ontogenesis of T cells in the thymus is a complex process whose molecular control is poorly understood. The present study investigated microRNAs involved in human thymocyte differentiation by comparing the microRNA expression profiles of thymocytes at the double-positive, single-positive CD4+ and single-positive CD8+ maturation stages. Microarray analysis showed that each thymocyte population displays a distinct microRNA expression profile that reflects their developmental relationships. Moreover, analysis of small-RNA libraries generated from human unsorted and double-positive thymocytes and from mature peripheral CD4+ and CD8+ T lymphocytes, together with the microarray data, indicated a trend toward up-regulation of microRNA expression during T-cell maturation after the double-positive stage and revealed a group of microRNAs regulated during normal T-cell development, including miR-150, which is strongly up-regulated as maturation progresses. We showed that miR-150 targets NOTCH3, a member of the Notch receptor family that plays important roles both in T-cell differentiation and leukemogenesis. Forced expression of miR-150 reduces NOTCH3 levels in T-cell lines and has adverse effects on their proliferation and survival. Overall, these findings suggest that control of the Notch pathway through miR-150 may have an important impact on T-cell development and physiology. [ABSTRACT FROM AUTHOR]

Published
2011
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