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1. ComPair-2: A Next Generation Medium Energy Gamma-ray Telescope Prototype

Author

Caputo, Regina, Kierans, Carolyn, Cannady, Nicholas, Falcone, Abe, Fukazawa, Yasushi, Jadhav, Manoj, Kerr, Matthew, Kirschner, Nicholas, Kumar, Kavic, Laviron, Adrien, Leys, Richard, Liceaga-Indart, Iker, McEnery, Julie, Metcalfe, Jessica, Metzler, Zachary, Miller, Nathan, Mitchell, John, Parker, Lucas, Peric, Ivan, Perkins, Jeremy, Phlips, Bernard, Racusin, Judith, Sasaki, Makoto, Segal, Kenneth N., Shy, Daniel, Steinhebel, Amanda L., Striebig, Nicolas, Suda, Yusuke, Tajima, Hiroyasu, Valverde, Janeth, Violette, Daniel P., Woolf, Richard, and Zoglauer, Andreas

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Many questions posed in the Astro2020 Decadal survey in both the New Messengers and New Physics and the Cosmic Ecosystems science themes require a gamma-ray mission with capabilities exceeding those of existing (e.g. Fermi, Swift) and planned (e.g. COSI) observatories. ComPair, the Compton Pair telescope, is a prototype of such a next-generation gamma-ray mission. It had its inaugural balloon flight from Ft. Sumner, New Mexico in August 2023. To continue the goals of the ComPair project to develop technologies that will enable a future gamma-ray mission, the next generation of ComPair (ComPair-2) will be upgraded to increase the sensitivity and low-energy transient capabilities of the instrument. These advancements are enabled by AstroPix, a silicon monolithic active pixel sensor, in the tracker and custom dual-gain silicon photomultipliers and front-end electronics in the calorimeter. This effort builds on design work for the All-sky Medium Energy Gamma-ray Observatory eXplorer (AMEGO-X) concept that was submitted the 2021 MIDEX Announcement of Opportunity. Here we describe the ComPair-2 prototype design and integration and testing plans to advance the readiness level of these novel technologies., Comment: 11 pages, 7 figures, SPIE Astronomical Telescopes and Instrumentation 2004 conference proceedings

Published
2024
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2. The 2023 Balloon Flight of the ComPair Instrument

Author

Smith, Lucas D., Cannady, Nicholas, Caputo, Regina, Kierans, Carolyn, Kirschner, Nicholas, Liceaga-Indart, Iker, McEnery, Julie, Metzler, Zachary, Moiseev, A. A., Parker, Lucas, Perkins, Jeremy, Sasaki, Makoto, Schoenwald, Adam J., Shy, Daniel, Valverde, Janeth, Wasti, Sambid, Woolf, Richard, Bolotnikov, Aleksey, Caligiure, Thomas J., Crosier, A. Wilder, Fried, Jack, Ghosh, Priyarshini, Griffin, Sean, Grove, J. Eric, Hays, Elizabeth, Kong, Emily, Mitchell, John, Phlips, Bernard, Sleator, Clio, Thompson, D. J., Wulf, Eric, and Zajczyk, Anna

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The ComPair balloon instrument is a prototype gamma-ray telescope that aims to further develop technology for observing the gamma-ray sky in the MeV regime. ComPair combines four detector subsystems to enable parallel Compton scattering and pair-production detection, critical for observing in this energy range. This includes a 10 layer double-sided silicon strip detector tracker, a virtual Frisch grid low energy CZT calorimeter, a high energy CsI calorimeter, and a plastic scintillator anti-coincidence detector. The inaugural balloon flight successfully launched from the Columbia Scientific Balloon Facility site in Fort Sumner, New Mexico, in late August 2023, lasting approximately 6.5 hours in duration. In this proceeding, we discuss the development of the ComPair Since balloon payload, the performance during flight, and early results., Comment: 13 pages, 12 figures

Published
2024
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4. Results from the CsI Calorimeter onboard the 2023 ComPair Balloon Flight

Author

Shy, Daniel, Woolf, Richard S., Sleator, Clio, Phlips, Bernard, Grove, J. Eric, Wulf, Eric A., Johnson-Rambert, Mary, Davis, Mitch, Kong, Emily, Caligiure, Thomas, Crosier, A. Wilder, Bolotnikov, Aleksey, Cannady, Nicholas, Carini, Gabriella A., Caputo, Regina, Fried, Jack, Ghosh, Priyarshini, Griffin, Sean, Hays, Elizabeth, Herrmann, Sven, Kierans, Carolyn, Kirschner, Nicholas, Liceaga-Indart, Iker, Metzler, Zachary, McEnery, Julie, Mitchell, John, Moiseev, A. A., Parker, Lucas, Dellapenna, Alfred, Perkins, Jeremy S., Sasaki, Makoto, Schoenwald, Adam J., Smith, Lucas D., Valverde, Janeth, Wasti, Sambid, and Zajczyk, Anna

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Nuclear Experiment
Abstract

The ComPair gamma-ray telescope is a technology demonstrator for a future gamma-ray telescope called the All-sky Medium Energy Gamma-ray Observatory (AMEGO). The instrument is composed of four subsystems, a double-sided silicon strip detector, a virtual Frisch grid CdZnTe calorimeter, a CsI:Tl based calorimeter, and an anti-coincidence detector (ACD). The CsI calorimeter's goal is to measure the position and energy deposited from high-energy events. To demonstrate the technological readiness, the calorimeter has flown onboard a NASA scientific balloon as part of the GRAPE-ComPair mission and accumulated around 3 hours of float time at an altitude of 40 km. During the flight, the CsI calorimeter observed background radiation, Regener-Pfotzer Maximum, and several gamma-ray activation lines originating from aluminum.

Published
2024

5. The Compton-Pair telescope: A prototype for a next-generation MeV $\gamma$-ray observatory

Author

Valverde, Janeth, Kirschner, Nicholas, Metzler, Zachary, Smith, Lucas D., Cannady, Nicholas, Caputo, Regina, Kierans, Carolyn, Liceaga-Indart, Iker, Moiseev, Alexander, Parker, Lucas, Sasaki, Makoto, Schoenwald, Adam, Shy, Daniel, Wasti, Sambid, Woolf, Richard, Bolotnikov, Aleksey, Carini, Gabriella, Crosier, A. W., Caligure, T., Dellapenna Jr, Alfred, Fried, Jack, Ghosh, P., Griffin, Sean, Grove, J. Eric, Hays, Elizabeth, Herrmann, Sven, Kong, Emily, McEnery, Julie, Mitchell, John, Perkins, Jeremy S., Phlips, Bernard, Sleator, Clio, Wulf, Eric, and Zajczyk, Anna

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The Compton Pair (ComPair) telescope is a prototype that aims to develop the necessary technologies for future medium energy gamma-ray missions and to design, build, and test the prototype in a gamma-ray beam and balloon flight. The ComPair team has built an instrument that consists of 4 detector subsystems: a double-sided silicon strip detector Tracker, a novel high-resolution virtual Frisch-grid cadmium zinc telluride Calorimeter, and a high-energy hodoscopic cesium iodide Calorimeter, all of which are surrounded by a plastic scintillator anti-coincidence detector. These subsystems together detect and characterize photons via Compton scattering and pair production, enable a veto of cosmic rays, and are a proof-of-concept for a space telescope with the same architecture. A future medium-energy gamma-ray mission enabled through ComPair will address many questions posed in the Astro2020 Decadal survey in both the New Messengers and New Physics and the Cosmic Ecosystems themes. In this contribution, we will give an overview of the ComPair project and steps forward to the balloon flight., Comment: Proceedings for the 38th International Cosmic Ray Conference (ICRC2023)

Published
2023
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7. Development of the ComPair gamma-ray telescope prototype

Author

Shy, Daniel, Kierans, Carolyn, Cannady, Nicolas, Caputo, Regina, Griffin, Sean, Grove, J. Eric, Hays, Elizabeth, Kong, Emily, Kirschner, Nicholas, Liceaga-Indart, Iker, McEnery, Julie, Mitchell, John, Moiseev, A. A., Parker, Lucas, Perkins, Jeremy S., Phlips, Bernard, Sasaki, Makoto, Schoenwald, Adam J., Sleator, Clio, Smith, Jacob, Smith, Lucas D., Wasti, Sambid, Woolf, Richard, Wulf, Eric, and Zajczyk, Anna

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Physics - Instrumentation and Detectors
Abstract

There is a growing interest in the science uniquely enabled by observations in the MeV range, particularly in light of multi-messenger astrophysics. The Compton Pair (ComPair) telescope, a prototype of the AMEGO Probe-class concept, consists of four subsystems that together detect and characterize gamma rays in the MeV regime. A double-sided strip silicon Tracker gives a precise measure of the first Compton scatter interaction and tracks pair-conversion products. A novel cadmium zinc telluride (CZT) detector with excellent position and energy resolution beneath the Tracker detects the Compton-scattered photons. A thick cesium iodide (CsI) calorimeter contains the high-energy Compton and pair events. The instrument is surrounded by a plastic anti-coincidence (ACD) detector to veto the cosmic-ray background. In this work, we will give an overview of the science motivation and a description of the prototype development and performance.

Published
2022
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8. Theoretical Analysis of SIRVVD Model to Provide Insight on the Target Rate of COVID-19/SARS-CoV-2 Vaccination in Japan

Author

Omae, Yuto, Sasaki, Makoto, Toyotani, Jun, Hara, Kazuyuki, and Takahashi, Hirotaka

Subjects
Quantitative Biology - Populations and Evolution, Mathematics - Dynamical Systems, Quantitative Biology - Quantitative Methods
Abstract

The effectiveness of the first and second dose vaccinations are different for COVID-19; therefore, a susceptible-infected-recovered-vaccination1-vaccination2-death (SIRVVD) model that can represent the states of the first and second vaccination doses has been proposed. By the previous study, we can carry out simulating the spread of infectious disease considering the effects of the first and second doses of the vaccination based on the SIRVVD model. However, theoretical analysis of the SIRVVD Model is insufficient. Therefore, we obtained an analytical expression of the infectious number, by treating the numbers of susceptible persons and vaccinated persons as parameters. We used the solution to determine the target rate of the vaccination for decreasing the infection numbers of the COVID-19 Delta variant (B.1.617) in Japan. Further, we investigated the target vaccination rates for cases with strong or weak variants by comparison with the COVID-19 Delta variant (B.1.617). This study contributes to the mathematical development of the SIRVVD model and provides insight into the target rate of the vaccination to decrease the number of infections., Comment: 9 pages, 6 figures

Published
2022
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9. Exploring the MeV Sky with a Combined Coded Mask and Compton Telescope: The Galactic Explorer with a Coded Aperture Mask Compton Telescope (GECCO)

Author

Orlando, Elena, Bottacini, Eugenio, Moiseev, Alexander, Bodaghee, Arash, Collmar, Werner, Ensslin, Torsten, Moskalenko, Igor V., Negro, Michela, Profumo, Stefano, Baring, Matthew G., Bolotnikov, Aleksey, Cannady, Nicholas, Carini, Gabriella A., Digel, Seth, Grenier, Isabelle A., Harding, Alice K., Hartmann, Dieter, Herrmann, Sven, Kerr, Matthew, Krivonos, Roman, Laurent, Philippe, Longo, Francesco, Morselli, Aldo, Sasaki, Makoto, Shawhan, Peter, Skinner, Gerry, Smith, Lucas D., Stecker, Floyd W., Strong, Andrew, Sturner, Steven, Thompson, David J., Tomsick, John A., Wadiasingh, Zorawar, Woolf, Richard S., Yates, Eric, and Zoglauer, Andreas

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The sky at MeV energies is currently poorly explored. Here we present an innovative mission concept that builds on and improves past and currently proposed missions at such energies. We outline the motivations for combining a coded mask and a Compton telescope and we define the scientific goals of such a mission. The Galactic Explorer with a Coded Aperture Mask Compton Telescope (GECCO) is a novel concept for a next-generation telescope covering hard X-ray and soft gamma-ray energies. The potential and importance of this approach that bridges the observational gap in the MeV energy range are presented. With the unprecedented angular resolution of the coded mask telescope combined with the sensitive Compton telescope, a mission such as GECCO can disentangle the discrete sources from the truly diffuse emission. Individual Galactic and extragalactic sources are detected. This also allows to understand the gamma-ray Galactic center excess and the Fermi Bubbles, and to trace the low-energy cosmic rays, and their propagation in the Galaxy. Nuclear and annihilation lines are spatially and spectrally resolved from the continuum emission and from sources, addressing the role of low-energy cosmic rays in star formation and galaxy evolution, the origin of the 511 keV positron line, fundamental physics, and the chemical enrichment in the Galaxy. Such an instrument also detects explosive transient gamma-ray sources, which enable identifying and studying the astrophysical objects that produce gravitational waves and neutrinos in a multi-messenger context. By looking at a poorly explored energy band it also allows discoveries of new astrophysical phenomena., Comment: 16 pages. Contact authors: Elena Orlando, Eugenio Bottacini

Published
2021
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10. Bayesian inference of ion velocity distribution function from laser-induced fluorescence spectra

Author

Tokuda, Satoru, Kawachi, Yuichi, Sasaki, Makoto, Arakawa, Hiroyuki, Yamasaki, Kotaro, Terasaka, Kenichiro, and Inagaki, Shigeru

Subjects
Physics - Plasma Physics, Condensed Matter - Statistical Mechanics, Physics - Data Analysis, Statistics and Probability
Abstract

The velocity distribution function is a statistical description that connects particle kinetics and macroscopic parameters in many-body systems. Laser-induced fluorescence (LIF) spectroscopy is utilized to measure the local velocity distribution function in spatially inhomogeneous plasmas. However, the analytic form of such a function for the system of interest is not always clear under the intricate factors in non-equilibrium states. Here, we propose a novel approach to select the valid form of the velocity distribution function based on Bayesian statistics. We formulate the Bayesian inference of ion velocity distribution function and apply it to LIF spectra locally observed at several positions in a linear magnetized plasma. We demonstrate evaluating the spatial inhomogeneity by verifying each analytic form of the local velocity distribution function. Our approach is widely applicable to experimentally establish the velocity distribution function in plasmas and fluids, including gases and liquids.

Published
2021
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11. Effects of sawtooth heat pulses on edge flows and turbulence in a tokamak plasma

Author

Kaijun, ZHAO, NAGASHIMA, Yoshihiko, Zhibin, GUO, DIAMOND, Patrick H, Jiaqi, DONG, Longwen, YAN, Kimitaka, ITOH, ITOH, Sanae-I, Xiaobo, LI, Jiquan, LI, FUJISAWA, Akihide, INAGAKI, Shigeru, CHENG, Jun, Jianqiang, XU, KOSUGA, Yusuke, SASAKI, Makoto, Zhengxiong, WANG, ZHANG, Huaiqiang, Yuqian, CHEN, Xiaogang, CAO, Deliang, YU, Yi, LIU, Xianming, SONG, Fan, XIA, and Shuo, WANG

Subjects
tokamak, Langmuir probe arrays, edge flows and turbulence, sawtooth heat pulses, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Fluids & Plasmas
Abstract

Abstract Enhancements of edge zonal flows, radial electric fields, and turbulence are observed in electron cyclotron resonance heating-heated plasmas (Zhao et al 2013 Nucl. Fusion 53 083011). In this paper, the effects of sawtooth heat pulses on flows and turbulence are presented. These experiments are performed using multiple Langmuir probe arrays in the edge plasmas of the HL-2A tokamak. The edge zonal flows, radial electric fields, and turbulence are all enhanced by sawteeth. Propagation of the zonal flow and turbulence intensities is also observed. The delay time of the maximal intensity of the electric fields, zonal flows, and turbulence with respect to the sawtooth crashes is estimated as ∼1 ms and comparable to that of the sawtooth-triggered intermediate phases. Not only the zonal flows but also the radial electric fields lag behind the turbulence. Furthermore, the intensities of both the zonal flows and electric fields nearly linearly increase/decrease with the increase/decrease of the turbulence intensity. A double-source predator–prey model analysis suggests that a relatively strong turbulence source may contribute to the dominant zonal flow formation during sawtooth cycles.

Published
2022

16. Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation

Author

Hanyuda, Akiko, Goto, Atsushi, Katagiri, Ryoko, Koyanagi, Yuriko N., Nakatochi, Masahiro, Sutoh, Yoichi, Nakano, Shiori, Oze, Isao, Ito, Hidemi, Yamaji, Taiki, Sawada, Norie, Iwagami, Masao, Kadota, Aya, Koyama, Teruhide, Katsuura-Kamano, Sakurako, Ikezaki, Hiroaki, Tanaka, Keitaro, Takezaki, Toshiro, Imoto, Issei, Suzuki, Midori, Momozawa, Yukihide, Takeuchi, Kenji, Narita, Akira, Hozawa, Atsushi, Kinoshita, Kengo, Shimizu, Atsushi, Tanno, Kozo, Matsuo, Keitaro, Tsugane, Shoichiro, Wakai, Kenji, Sasaki, Makoto, Yamamoto, Masayuki, and Iwasaki, Motoki

Published
2023
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20. Final Analysis of COVID-19 Patients With Inflammatory Bowel Disease in Japan (J-COSMOS): A Multicenter Registry Cohort Study

Author

Sasaki, Makoto, Iizuka, Masahiro, Fujiya, Mikihiro, Matsumoto, Takayuki, Kinjo, Fukunori, Nakamura, Shiro, Kamata, Noriko, Iijima, Hideki, Etani, Yuri, Ueno, Fumiaki, Hiraoka, Sakiko, Kondo, Takeo, Kagaya, Takashi, Naganuma, Makoto, Kobayashi, Kiyonori, Kobayashi, Taku, Yamamoto, Shuji, Naito, Yuji, Hisamatsu, Tadakazu, Furuta, Yoki, Mitsuyama, Keichi, Hashimoto, Yu, Arai, Katsuhiro, Kato, Shingo, Iwama, Itaru, Esaki, Motohiro, Tanaka, Hiroki, Nakase, Hiroshi, Motoya, Satoshi, Maemoto, Atsuo, Ashida, Toshifumi, Nishimata, Nobuaki, Aono, Shigeaki, Andoh, Akira, Yamamoto, Hironori, Ishihara, Shunji, Shimizu, Toshiaki, Yasuharu, Maeda, Kinoshita, Kenji, Fukuda, Katuyuki, Kato, Jun, Takeuchi, Ken, Nagahori, Masakazu, Fukuzawa, Masakatsu, Saruta, Masayuki, Suzuki, Takayoshi, Itabashi, Michio, Shinozaki, Masaru, Ishihara, Soichiro, Yoshimura, Naoki, Matsuoka, Katsuyoshi, Kakuta, Yoichi, Takahashi, Kenichi, Tominaga, Keiichi, Sakemi, Ryosuke, Nanjo, Sohachi, Yoshikawa, Shusaku, Ozeki, Keiji, Fuchigami, Ayako, Katsurada, Takehiko, Watanabe, Kenji, Sakuraba, Hirotake, Hirai, Fumihito, Hisabe, Takashi, Iwase, Shigeru, Ohmiya, Naoki, Hokari, Ryota, Nakai, Katsuhiko, Ueda, Takeshi, Abukawa, Daiki, Yamamoto, Shojiro, Koganei, Kazutaka, Kunisaki, Reiko, Hokama, Akira, Hayashi, Yuki, Yokoyama, Yoshihiro, and Matsuura, Minoru

Published
2023
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21. Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Jager, Phil L., de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Børge G., O’Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Trégouët, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjærg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Irvin, Marguerite R., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, França, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Paré, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Anderson, Christopher D., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernández-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie

Published
2022
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22. SuperTIGER instrument abundances of galactic cosmic rays for the charge interval [formula omitted]

Author

Walsh, Nathan Elliot, Akaike, Yosui, Binns, Walter Robert, Bose, Richard G., Brandt, Terri J., Braun, Dana L., Cannady, Nicholas W., Dowkontt, Paul F., Hams, Thomas, Israel, Martin H., Krizmanic, John F., Labrador, Allan W., Mewaldt, Richard A., Mitchell, John W., Murphy, Ryan P., de Nolfo, Georgia A., Nutter, Scott, Olevitch, Martin A., Rauch, Brian. F., Sakai, Kenichi, Sasaki, Makoto, Simburger, Garry E., Stone, Ed C., Tatoli, Teresa, Ward, John Ennis, Wiedenbeck, Mark E., and Zober, Wolfgang V.

Published
2022
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25. Peripheral nerve regeneration using a bioresorbable silk fibroin-based artificial nerve conduit fabricated via a novel freeze–thaw process.

Author

Matsuo, Tomoki, Kimura, Hiroo, Nishijima, Takayuki, Kiyota, Yasuhiro, Suzuki, Taku, Nagoshi, Narihito, Shibata, Shinsuke, Shindo, Tomoko, Moritoki, Nobuko, Sasaki, Makoto, Noguchi, Sarara, Tamada, Yasushi, Nakamura, Masaya, and Iwamoto, Takuji

Abstract

While silk fibroin (SF) obtained from silkworm cocoons is expected to become a next-generation natural polymer, a fabrication method for SF-based artificial nerve conduits (SFCs) has not yet been established. Here, we report a bioresorbable SFC, fabricated using a novel freeze–thaw process, which ensures biosafety by avoiding any harmful chemical additives. The SFC demonstrated favorable biocompatibility (high hydrophilicity and porosity with a water content of > 90%), structural stability (stiffness, toughness, and elasticity), and biodegradability, making it an ideal candidate for nerve regeneration. We evaluated the nerve-regenerative effects of the SFC in a rat sciatic-nerve-defect model, including its motor and sensory function recovery as well as histological regeneration. We found that SFC transplantation significantly promoted functional recovery and nerve regeneration compared to silicone tubes and was almost equally effective as autologous nerve transplantation. Histological analyses indicated that vascularization and M2 macrophage recruitment were pronounced inside the SFC. These results suggest that the unique properties of the SFC further enhanced the peripheral nerve regeneration mechanism. As no SFC has been applied in clinical practice, the SFC reported herein may be a promising candidate for repairing extensive peripheral nerve defects. [ABSTRACT FROM AUTHOR]

Published
2025
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27. Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

Author

Temprano‐Sagrera, Gerard, Sitlani, Colleen M., Bone, William P., Martin‐Bornez, Miguel, Voight, Benjamin F., Morrison, Alanna C., Damrauer, Scott M., de Vries, Paul S., Smith, Nicholas L., Sabater‐Lleal, Maria, Dehghan, Abbas, Heath, Adam S, Morrison, Alanna C, Reiner, Alex P, Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M, Hayward, Caroline, Ward‐Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P, Tregouet, David A, Mook‐Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W, Leebeek, Frank W.G., Rosendaal, Frits R, Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A, Bressler, Jan, Huffman, Jennifer E, Rotter, Jerome I, Yao, Jie, Wilson, James F, Bis, Joshua C, Hahn, Julie M, Desch, Karl C, Wiggins, Kerri L, Raffield, Laura M, Bielak, Lawrence F, Yanek, Lisa R, Kleber, Marcus E, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Liu, Melissa, Brown, Michael R, Conomos, Matthew P, Jhun, Min‐A, Chen, Ming‐Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L, Peyser, Patricia A, Elliot, Paul, de Vries, Paul S, Wei, Peng, Wild, Philipp S, Morange, Pierre E, van der Harst, Pim, Yang, Qiong, Le, Ngoc‐Quynh, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M, Cox, Simon R, Trompet, Stella, Felix, Stephan B, Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Haessler, Jeffrey, Brumpton, Ben M, Chasman, Daniel I, Suchon, Pierre, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Jackson, Rabecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, Frazer, Kelly A, McCauley, Bryan M, Taylor, Kent, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean‐François, O’Donnell, Chris J, Kim, Jihye, Kraft, Peter, Hansen, John‐Bjarne, Heit, John A, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M, Morange, Pierre‐Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, Trégouët, David‐Alexandre, Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten‐Jacobs, Loes, Giese, Anne‐Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chen, Wei‐Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Holliday, Elizabeth G, Howard, George, Hsu, Fang‐Chi, Hyacinth, Hyacinth I, Arfan Ikram, M, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez‐Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin‐Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei‐Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O’Donnell, Martin J, Pulit, Sara L, Rannikmäe, Kristiina, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Rost, Natalia S, Rothwell, Peter M, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil‐Smoller, Sylvia, Wilson, James G, Yusuf, Salim, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu‐Ching, Hoan Choi, Seung, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean‐François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Mei Liu, Yong, Lopez, Oscar L, Makoto, Hirata, Martinez‐Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller‐Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Reddy Peddareddygari, Leema, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba‐Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti‐Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano‐Tárraga, Carolina, Stanne, Tara, Colin Stine, O, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres‐Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez‐Cadenas, Israel, Longstreth, W T, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin

Published
2022
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29. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project

Author

Kawame, Hiroshi, Fukushima, Akimune, Fuse, Nobuo, Nagami, Fuji, Suzuki, Yoichi, Sakurai-Yageta, Mika, Yasuda, Jun, Yamaguchi-Kabata, Yumi, Kinoshita, Kengo, Ogishima, Soichi, Takai, Takako, Kuriyama, Shinichi, Hozawa, Atsushi, Nakaya, Naoki, Nakamura, Tomohiro, Minegishi, Naoko, Sugawara, Junichi, Suzuki, Kichiya, Tomita, Hiroaki, Uruno, Akira, Kobayashi, Tomoko, Aizawa, Yayoi, Tokutomi, Tomoharu, Yamamoto, Kayono, Ohneda, Kinuko, Kure, Shigeo, Aoki, Yoko, Katagiri, Hideki, Ishigaki, Yasushi, Sawada, Shojiro, Sasaki, Makoto, and Yamamoto, Masayuki

Published
2022
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32. Background factors involved in the epidemiology of functional constipation in the Japanese population: a cross-sectional study

Author

Yamamoto, Sayuri, Ohashi, Wataru, Yamaguchi, Yoshiharu, Inamoto, Shunsuke, Koshino, Akira, Sugiyama, Tomoya, Nagao, Kazuhiro, Tamura, Yasuhiro, Izawa, Shinya, Ebi, Masahide, Usami, Jun, Hamano, Koichi, Izumi, Junko, Wakita, Yoshinori, Funaki, Yasushi, Ogasawara, Naotaka, Sasaki, Makoto, Maekawa, Masato, and Kasugai, Kunio

Published
2022
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37. Real-world status of treatment for lymphoid neoplasms developed during the course of myeloproliferative neoplasms in Japan.

Author

Edahiro, Yoko, Ochiai, Tomonori, Hashimoto, Yoshinori, Ichii, Michiko, Okatani, Takeshi, Omura, Hiromi, Nakajima, Kei, Sasaki, Makoto, Ando, Jun, Takaku, Tomoiku, Koike, Michiaki, Izumiyama, Koh, Hiraga, Junji, Yano, Tomofumi, Usuki, Kensuke, Ohtsuka, Eiichi, Yokoyama, Kenji, Oyake, Tatsuo, Takahashi, Naoki, and Nishida, Tetsuya

Subjects
DIFFUSE large B-cell lymphomas, GRANULOCYTE-colony stimulating factor, CHRONIC lymphocytic leukemia, POLYCYTHEMIA vera, MYELOPROLIFERATIVE neoplasms
Abstract

Objectives: Patients with myeloproliferative neoplasms (MPNs) are at higher risk of developing secondary malignancies. In this study, we focused on patients with MPNs that complicated lymphoid neoplasms. To analyze the real-world status of lymphoid neoplasm treatment in patients with pre-existing MPNs in Japan, we conducted a multicenter retrospective study. Methods: Questionnaires were sent to collect the data on patients who were first diagnosed with either polycythemia vera, essential thrombocythemia or myelofibrosis and who later were complicated with lymphoid neoplasms defined as malignant lymphoma, multiple myeloma, or chronic lymphocytic leukemia/small cell lymphoma. Results: Twenty-four patients with MPNs complicated by lymphoid neoplasms were enrolled (polycythemia vera, n = 8; essential thrombocythemia, n = 14; and primary myelofibrosis, n = 2). Among these, diffuse large B-cell lymphoma (DLBCL) was the most frequently observed (n = 13, 54.1%). Twelve (92.3%) of the patients with DLBCL received conventional chemotherapy. Among these 12 patients, regarding cytoreductive therapy for MPNs, 8 patients stopped treatment, one continued treatment, and two received a reduced dose. Consequently, most patients were able to receive conventional chemotherapy for DLBCL with a slightly higher dose of granulocyte colony-stimulating factor support than usual without worse outcomes. All 3 patients with multiple myeloma received a standard dose of chemotherapy. Conclusion: Our data indicate that if aggressive lymphoid neoplasms develop during the course of treatment in patients with MPNs, it is acceptable to prioritize chemotherapy for lymphoma. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Significance of Conducting 2 Types of Fecal Tests in Patients With Ulcerative Colitis

Author

Naganuma, Makoto, Kobayashi, Taku, Nasuno, Masanao, Motoya, Satoshi, Kato, Shingo, Matsuoka, Katsuyoshi, Hokari, Ryota, Watanabe, Chikako, Sakamoto, Hirotsugu, Yamamoto, Hironori, Sasaki, Makoto, Watanabe, Kenji, Iijima, Hideki, Endo, Yutaka, Ichikawa, Hitoshi, Ozeki, Keiji, Tanida, Satoshi, Ueno, Nobuhiro, Fujiya, Mikihiro, Sako, Minako, Takeuchi, Ken, Sugimoto, Shinya, Abe, Takayuki, Hibi, Toshifumi, Suzuki, Yasuo, and Kanai, Takanori

Published
2020
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39. Dose Evaluation in Two-Phase Method for Advanced Esophageal Cancer by Hybrid Irradiation Techniques

Author

Sasaki, Makoto, primary, Tamamura, Hiroyasu, additional, Tameshige, Yuji, additional, Azuma, Yuya, additional, Maeda, Yoshikazu, additional, Matsushita, Keiichiro, additional, Sato, Yoshitaka, additional, Takamatsu, Shigeyuki, additional, Inoue, Kazuya, additional, Tabata, Yoji, additional, Yoshimura, Hitoshi, additional, and Yamamoto, Kazutaka, additional

Published
2024
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40. Neutrino Telescope Array Letter of Intent: A Large Array of High Resolution Imaging Atmospheric Cherenkov and Fluorescence Detectors for Survey of Air-showers from Cosmic Tau Neutrinos in the PeV-EeV Energy Range

Author

Sasaki, Makoto and Hou, George Wei-Shu

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

This Letter of Intent (LoI) describes the outline and plan for the Neutrino Telescope Array (NTA) project. High-energy neutrinos provide unique and indisputable evidence for hadronic acceleration. Recently, IceCube has reported astronomical neutrino candidates in excess of expectation from atmospheric secondaries, but is limited by the water Cherenkov detection method. A next generation high-energy neutrino telescope should be capable of establishing indisputable evidence for cosmic high-energy neutrinos. It should not only have orders-of-magnitude larger sensitivity, but also enough pointing accuracy to probe known or unknown astronomical objects, without suffering from atmospheric secondaries. The proposed installation is a large array of compound eye stations of imaging atmospheric Cherenkov and fluorescence detectors, with wide field of view and refined observational ability of air showers from cosmic tau neutrinos in the PeV-EeV energy range. This advanced optical complex system is based substantially on the development of All-sky Survey High Resolution Air-shower detector (Ashra) and applies the tau shower Earth-skimming method to survey PeV-EeV tau neutrinos. It allows wide (30 deg x 360 deg) and deep (~400 Mpc) survey observation for PeV-EeV tau neutrinos assuming the standard GRB neutrino fluence.In addition, it enjoys the pointing accuracy of better than 0.2 deg in essentially background-free conditions. With the advanced imaging of Earth-skimming tau showers in the wide field of view, we aim for clear discovery and identification of astronomical tau neutrino sources, providing inescapable evidence of the astrophysical hadronic model for acceleration and/or propagation of extremely high energy protons in the precisely determined direction., Comment: 33 pages, 22 figures

Published
2014

43. M. Wintermark et al.

Author

Wintermark, Max, Luby, Marie, Bornstein, Natan M, Demchuk, Andrew, Fiehler, Jens, Kudo, Kohsuke, Lees, Kennedy R, Liebeskind, David S, Michel, Patrik, Nogueira, Raul G, Parsons, Mark W, Sasaki, Makoto, Wardlaw, Joanna M, Wu, Ona, Zhang, Weiwei, Zhu, Guangming, and Warach, Steven J

Subjects
Clinical Research, Brain Disorders, Stroke, Clinical Trials and Supportive Activities, Decision Making, Diagnostic Imaging, Female, Follow-Up Studies, Humans, International Cooperation, Male, Randomized Controlled Trials as Topic, Surveys and Questionnaires, Thrombolytic Therapy, Time Factors, CT, MRI, penumbra, perfusion imaging, stroke, vascular imaging, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract

BackgroundTo assess the differences across continental regions in terms of stroke imaging obtained for making acute revascularization therapy decisions, and to identify obstacles to participating in randomized trials involving multimodal imaging.MethodsSTroke Imaging Repository (STIR) and Virtual International Stroke Trials Archive (VISTA)-Imaging circulated an online survey through its website, through the websites of national professional societies from multiple countries as well as through email distribution lists from STIR and the above mentioned societies.ResultsWe received responses from 223 centers (2 from Africa, 38 from Asia, 10 from Australia, 101 from Europe, 4 from Middle East, 55 from North America, 13 from South America). In combination, the sites surveyed administered acute revascularization therapy to a total of 25,326 acute stroke patients in 2012. Seventy-three percent of these patients received intravenous (i.v.) tissue plasminogen activator (tPA), and 27%, endovascular therapy. Vascular imaging was routinely obtained in 79% (152/193) of sites for endovascular therapy decisions, and also as part of standard IV tPA treatment decisions at 46% (92/198) of sites. Modality, availability and use of acute vascular and perfusion imaging before revascularization varied substantially between geographical areas. The main obstacles to participate in randomized trials involving multimodal imaging included: mainly insufficient research support and staff (50%, 79/158) and infrequent use of multimodal imaging (27%, 43/158) .ConclusionThere were significant variations among sites and geographical areas in terms of stroke imaging work-up used tomake decisions both for intravenous and endovascular revascularization. Clinical trials using advanced imaging as a selection tool for acute revascularization therapy should address the need for additional resources and technical support, and take into consideration the lack of routine use of such techniques in trial planning.

Published
2015

45. Cherenkov Tau Shower Earth-Skimming Method for PeV-EeV Tau Neutrino Observation with Ashra

Author

Asaoka, Yoichi and Sasaki, Makoto

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We describe a method of observation for PeV--EeV tau neutrinos using Cherenkov light from the air showers of decayed taus produced by tau neutrino interactions in the Earth. Aiming for the realization of neutrino astronomy utilizing the Earth-skimming tau neutrino detection technique, highly precise determination of arrival direction is key due to the following issues: (1) Clear identification of neutrinos by identifying those vertices originating within the Earth's surface; (2) Identification of very high energy neutrino sources. The Ashra detector uses newly developed light collectors which realize both a 42 degree-diameter field-of-view and arcminute resolution. Therefore, it has superior angular resolution for imaging Cherenkov air showers. In this paper, we estimate the sensitivity of and cosmic-ray background resulting from application of the Ashra-1 Cherenkov tau shower observation method. Both data from a commissioning run and a long-term observation (with fully equipped trigger system and one light collector) are presented. Our estimates are based on a detailed Monte Carlo simulation which describes all relevant shower processes from neutrino interaction to Cherenkov photon detection produced by tau air showers. In addition, the potential to determine the arrival direction of Cherenkov showers is evaluated by using the maximum likelihood method. We conclude that the Ashra-1 detector is a unique probe into detection of very high energy neutrinos and their accelerators., Comment: 15 pages, 7 figures, accepted for publication in Astroparticle Physics

Published
2012
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46. Performance of a 20-in. photoelectric lens image intensifier tube

Author

Asaoka, Yoichi and Sasaki, Makoto

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

We have evaluated a 20-in. photoelectric lens image intensifier tube (PLI) to be mounted on the spherical focal surface of the Ashra light collectors, where Ashra stands for All-sky Survey High Resolution Air-shower Detector, an unconventional optical collector complex that images air showers produced by very high energy cosmic-ray particles in a 42$^\circ$-diameter field of view with a resolution of a few arcminutes. The PLI, the worlds largest image intensifier, has a very large effective photocathode area of 20-in. diameter and reduces an image size to less than 1-inch diameter using the electric lens effect. This enables us to use a solid-state imager to take focal surface images in the Ashra light collector. Thus, PLI is a key technology for the Ashra experiment to realize a much lower pixel cost in comparison with other experiments using photomultiplier arrays at the focal surface. In this paper we present the design and performance of the 20-in. PLI., Comment: 12 pages, 7 fugres

Published
2011
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47. Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Jager, Phil L., de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Børge G., O’Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Trégouët, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjærg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Irvin, Marguerite R., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, França, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Paré, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Anderson, Christopher D., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernández-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie

Published
2022
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49. Protocol of a phase II study to evaluate the efficacy and safety of deep-inspiration breath-hold daily online adaptive radiotherapy for centrally located lung tumours (PUDDING study)

Author

Kishi, Noriko, primary, Yoneyama, Masahiro, additional, Inoo, Hiroyuki, additional, Inoue, Minoru, additional, Iramina, Hiraku, additional, Nakakura, Akiyoshi, additional, Ono, Tomohiro, additional, Hirashima, Hideaki, additional, Adachi, Takanori, additional, Matsushita, Norimasa, additional, Sasaki, Makoto, additional, Fujimoto, Takahiro, additional, Nakamura, Mitsuhiro, additional, Matsuo, Yukinori, additional, and Mizowaki, Takashi, additional

Published
2024
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