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2. Assessment of the Psychometric Characteristics of the Italian Version of the Nurse Manager Actions Scale

Author

Lommi, Marzia, primary, Caruso, Rosario, additional, Conte, Gianluca, additional, Magon, Arianna, additional, Porcelli, Barbara, additional, Stievano, Alessandro, additional, Rocco, Gennaro, additional, Notarnicola, Ippolito, additional, Sabatino, Laura, additional, Latina, Roberto, additional, De Maria, Maddalena, additional, Di Simone, Emanuele, additional, De Benedictis, Anna, additional, Gualandi, Raffaella, additional, Tartaglini, Daniela, additional, and Ivziku, Dhurata, additional

Published
2023
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3. Psychometric Properties of the Italian Version of the Leader Member Exchange Scale (LMX-7): A Validation Study

Author

Lommi, Marzia, primary, Notarnicola, Ippolito, additional, Caruso, Rosario, additional, Iacorossi, Laura, additional, Gambalunga, Francesca, additional, Sabatino, Laura, additional, Latina, Roberto, additional, Rea, Teresa, additional, Guillari, Assunta, additional, De Maria, Maddalena, additional, Mazzotta, Rocco, additional, Rocco, Gennaro, additional, Stievano, Alessandro, additional, Gualandi, Raffaella, additional, Tartaglini, Daniela, additional, and Ivziku, Dhurata, additional

Published
2023
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5. Evaluation of Standard Precautions Compliance Instruments: A Systematic Review Using COSMIN Methodology

Author

Lommi, Marzia, primary, De Benedictis, Anna, additional, Porcelli, Barbara, additional, Raffaele, Barbara, additional, Latina, Roberto, additional, Montini, Graziella, additional, Tolentino Diaz, Maria Ymelda, additional, Guarente, Luca, additional, De Maria, Maddalena, additional, Ricci, Simona, additional, Giovanniello, Dominique, additional, Rocco, Gennaro, additional, Stievano, Alessandro, additional, Sabatino, Laura, additional, Notarnicola, Ippolito, additional, Gualandi, Raffaella, additional, Tartaglini, Daniela, additional, and Ivziku, Dhurata, additional

Published
2023
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7. Appraisal and Evaluation of the Learning Environment Instruments of the Student Nurse: A Systematic Review Using COSMIN Methodology

Author

Lommi, Marzia, primary, De Benedictis, Anna, additional, Ricci, Simona, additional, Guarente, Luca, additional, Latina, Roberto, additional, Covelli, Giuliana, additional, Pozzuoli, Gianluca, additional, De Maria, Maddalena, additional, Giovanniello, Dominique, additional, Rocco, Gennaro, additional, Stievano, Alessandro, additional, Sabatino, Laura, additional, Notarnicola, Ippolito, additional, Gualandi, Raffaella, additional, Tartaglini, Daniela, additional, and Ivziku, Dhurata, additional

Published
2023
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10. Vitamin D Determinants, Status, and Antioxidant/Anti-inflammatory-Related Effects in Cardiovascular Risk and Disease: Not the Last Word in the Controversy.

Author

Della Nera, Giulia, Sabatino, Laura, Gaggini, Melania, Gorini, Francesca, and Vassalle, Cristina

Subjects
VITAMIN D, CARDIOVASCULAR diseases risk factors, CARDIOVASCULAR diseases
Abstract

Beyond its key role in calcium homeostasis, vitamin D has been found to significantly affect the cardiovascular (CV) system. In fact, low vitamin D levels have been associated with increased CV risk, as well as increased CV morbidity and mortality. The majority of effects of this molecule are related directly or indirectly to its antioxidative and anti-inflammatory properties. Generally, vitamin D insufficiency is considered for 25-hydroxyvitamin D (25(OH)D) levels between 21–29 ng/mL (corresponding to 52.5–72.5 nmol/L), deficiency as 25(OH)D levels less than 20 ng/mL (<50 nmol/L), and extreme deficiency as 25(OH)D less than 10 ng/mL (<25 nmol/L). However, the definition of an optimal vitamin D status, as defined by 25(OH)D, remains controversial for many extra-bone conditions, including CV disease. In this review, confounding factors affecting the 25(OH)D measurement and status will be discussed. In particular, available evidence on the mechanism and role of vitamin D in relation to CV risk and disease through its antioxidant effect will be reported, also facing the aspect regarding the debate on the minimum blood 25(OH)D level required to ensure optimal CV health. [ABSTRACT FROM AUTHOR]

Published
2023
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32. T3 enhances Ang2 in rat aorta in myocardial I/R: comparison with left ventricle.

Author

Sabatino, Laura, Kusmic, Claudia, Nicolini, Giuseppina, Amato, Rosario, Casini, Giovanni, Iervasi, Giorgio, and Balzan, Silvana

Subjects
*CORONARY heart disease treatment, *ANGIOPOIETINS, *NEOVASCULARIZATION, *LEFT heart ventricle diseases, ANIMAL models of coronary heart disease
Abstract

Angiogenesis is important for recovery after tissue damage in myocardial ischemia/ reperfusion, and tri-iodothyronine (T3) has documented effects on angiogenesis. The angiopoietins 1/2 and tyrosine kinase receptor represent an essential system in angiogenesis controlling endothelial cell survival and vascular maturation. Recently, in a 3-day ischemia/reperfusion rat model, the infusion of a low dose of T3 improved the post-ischemic recovery of cardiac function. Adopting this model, our study aimed to investigate the effects of T3 on the capillary index and the expression of angiogenic genes as the angiopoietins 1/2 and tyrosine kinase receptor system, in the thoracic aorta and in the left ventricle. In the thoracic aorta, T3 infusion significantly improved the angiogenic sprouting and angiopoietin 2 expression. Instead, Sham-T3 group did not show any significant increment of capillary density and angiopoietin 2 expression. In the area at risk (AAR) of the left ventricle, T3 infusion did not increase capillary density but restored levels of angiopoietin 1, which were reduced in I/R group. Angiopoietin 2 levels were similar to Sham group and unchanged by T3 administration. In the remote zone, T3 induced a significant increment of both angiopoietin 1/2. In conclusion, T3 infusion induced a different response of angiopoietin 1/2 between the ventricle (the AAR and the remote zone) and the thoracic aorta, probably reflecting the different action of angiopoietin 1/2 in cardiomyocytes and endothelial cells. Overall, these data suggest a new aspect of T3-mediated cardioprotection through angiogenesis. [ABSTRACT FROM AUTHOR]

Published
2016
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34. Atrial Natriuretic Peptide Is Not Degraded by the Lungs in Humans

Author

Iervasi, Giorgio, primary, Clerico, Aldo, additional, Pilo, Alessandro, additional, Sabatino, Laura, additional, Manfredi, Cristina, additional, Forini, Francesca, additional, Del Chicca, Maria Grazia, additional, Palmieri, Cataldo, additional, Ravani, Marcello, additional, and Donato, Luigi, additional

Published
1998
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35. H 2 S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?

Author

Gorini, Francesca, Del Turco, Serena, Sabatino, Laura, Gaggini, Melania, and Vassalle, Cristina

Subjects
SARS-CoV-2, ENDOTHELIUM diseases, THERAPEUTICS, BIOLOGY, VASCULAR endothelium, CARDIOVASCULAR diseases
Abstract

The endothelium controls vascular homeostasis through a delicate balance between secretion of vasodilators and vasoconstrictors. The loss of physiological homeostasis leads to endothelial dysfunction, for which inflammatory events represent critical determinants. In this context, therapeutic approaches targeting inflammation-related vascular injury may help for the treatment of cardiovascular disease and a multitude of other conditions related to endothelium dysfunction, including COVID-19. In recent years, within the complexity of the inflammatory scenario related to loss of vessel integrity, hydrogen sulfide (H2S) has aroused great interest due to its importance in different signaling pathways at the endothelial level. In this review, we discuss the effects of H2S, a molecule which has been reported to demonstrate anti-inflammatory activity, in addition to many other biological functions related to endothelium and sulfur-drugs as new possible therapeutic options in diseases involving vascular pathobiology, such as in SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Subclinical Carotid Atherosclerosis and Early Vascular Aging From Long-Term Low-Dose Ionizing Radiation Exposure A Genetic, Telomere, and Vascular Ultrasound Study in Cardiac Catheterization Laboratory Staff

Author

Andreassi, Maria Grazia, Piccaluga, Emanuela, Gargani, Luna, Sabatino, Laura, Borghini, Andrea, Faita, Francesco, Bruno, Rosa Maria, Padovani, Renato, Guagliumi, Giulio, and Picano, Eugenio

Subjects
catheterization laboratory, vascular aging, ionizing radiation exposure
Abstract

ObjectivesThis study sought to assess the association between long-term radiation exposure in the catheterization laboratory (cath lab) and early signs of subclinical atherosclerosis.BackgroundThere is growing evidence of an excess risk of cardiovascular disease at low-dose levels of ionizing radiation exposure.MethodsLeft and right carotid intima-media thickness (CIMT) was measured in 223 cath lab personnel (141 male; age, 45 ± 8 years) and 222 unexposed subjects (113 male; age, 44 ± 10 years). Leukocyte telomere length (LTL) was evaluated by quantitative reverse transcriptase polymerase chain reaction. The DNA repair gene XRCC3 Thr241Met polymorphism was also analyzed to explore the possible interaction with radiation exposure. The occupational radiological risk score (ORRS) was computed for each subject on the basis of the length of employment, individual caseload, and proximity to the radiation source. A complete lifetime effective dose (mSv) was recorded for 57 workers.ResultsLeft, right, and averaged CIMTs were significantly increased in high-exposure workers compared with both control subjects and low-exposure workers (all p values

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37. Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells

Author

Angela Papa, Paola Parlanti, Valentina Cappello, Virgilio Mattoli, Serena Del Turco, Gianni Ciofani, Chiara Caselli, Laura Sabatino, Rosetta Ragusa, Debora Battaglia, Giuseppina Basta, Mauro Gemmi, Del Turco, Serena, Ciofani, Gianni, Cappello, Valentina, Parlanti, Paola, Gemmi, Mauro, Caselli, Chiara, Ragusa, Rosetta, Papa, Angela, Battaglia, Debora, Sabatino, Laura, Basta, Giuseppina, and Mattoli, Virgilio

Subjects
senescence, Platelet Aggregation, medicine.medical_treatment, 02 engineering and technology, Fibrinogen, medicine.disease_cause, Antioxidants, Platelet, Cellular Senescence, nanoparticle, Metals and Alloys, Cerium, hemocompatibility, 021001 nanoscience & nanotechnology, endothelial cells, Cell biology, Endothelial stem cell, Cytokine, endothelial cell, 0210 nano-technology, medicine.drug, Blood Platelets, Materials science, Cell Survival, 0206 medical engineering, Biomedical Engineering, Vascular Cell Adhesion Molecule-1, Ceramics and Composite, Hemolysis, Fluorescence, Thromboplastin, Biomaterials, Tissue factor, Human Umbilical Vein Endothelial Cells, medicine, Humans, coagulation, nanoparticles, RNA, Messenger, Viability assay, Blood Coagulation, Hemostasis, Interleukin-6, Interleukin-8, DNA, Biomaterial, 020601 biomedical engineering, Ceramics and Composites, Reactive Oxygen Species, Oxidative stress
Abstract

Cerium oxide nanoparticles (nanoceria [NC]) have attracted much attention in biomedicine due to their surface composition that confers interesting redox activities and regenerative properties. Studies have demonstrated that the application of NPs in biomedicine can influence components of hemostatic system, inducing blood clotting, alterations of blood cells, and endothelial cell functions. NC were tested in vitro to assess their hemocompatibility and anticoagulant, anti-inflammatory, and anti-senescence activity in human endothelial cells. Hemocompatibility has been evaluated in vitro looking at the impact of NC on coagulation times, fibrinogen, and platelet aggregation. The effect of NC on vascular endothelial cells were assayed by testing cell viability, antioxidant activity, anticoagulant (tissue factor [TF]-mRNA expression) and anti-inflammatory properties (VCAM-1 exposure, cytokine release), and senescence (telomere shortening). NC did not show significant effects on coagulation process, hemolysis, or platelet aggregation. In endothelial cells, NC did not affect cell viability, reduced oxidative stress, inhibited mRNA-TF expression, VCAM-1 expression, and cytokine release. Moreover, NC reduce telomere shortening, possibly counteracting premature senescence. The hemocompatibility combined with anticoagulant and anti-inflammatory phenotype and the ability of counteract the premature senescence in vascular cells make NC a promising therapeutic tool in oxidative stress-related conditions. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

Published
2019

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