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Provides information on the treatment of HIV-related Castleman's disease (CD) with Interferon- α, a lymphoproliferative disorder. Medical history of a man with lymphadenopathy; Physical examination of the case; Impact of anti-retroviral therapy on multicentric CD.

Background: The aim of this study was to investigate whether a candidate gene, Sciellin (SCEL), mapping to the chromosome 13q21-q31 is mutated in esophageal cancer., Materials and Methods: The coding region and intron-exon junctions of SCEL were sequenced in 13 esophageal squamous cell cancers and matching normal esophageal samples to detect mutations., Results: Three single nucleotide polymorphisms were detected in SCEL of which two were silent mutations (L640L and H654H) and one missense mutation (R366K)., Conclusion: Single nucleotide polymorphisms were detected in both matching tumor and normal esophageal tissues but no disease-associated mutations suggesting that SCEL is not a major factor in esophageal squamous cell carcinogenesis.