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10. Preoperative levels of physical activity can be increased in pancreatectomy patients via a remotely monitored, telephone-based intervention: a randomized trial

Author

Rodriguez, Jorge G. Zarate, primary, Cos, Heidy, additional, Srivastava, Rohit, additional, Bewley, Alice, additional, Raper, Lacey, additional, Li, Dingwen, additional, Dai, Ruixuan, additional, Williams, Gregory A., additional, Fields, Ryan C., additional, Hawkins, William G., additional, Lu, Chenyang, additional, Sanford, Dominic E., additional, and Hammill, Chet W., additional

Published
2023
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11. Utility of a multidisciplinary tumor board in the management of pancreatic and upper gastrointestinal diseases: an observational study

Author

Brauer, David G., Strand, Matthew S., Sanford, Dominic E., Kushnir, Vladimir M., Lim, Kian-Huat, Mullady, Daniel K., Tan, Benjamin R., Jr., Wang-Gillam, Andrea, Morton, Ashley E., Ruzinova, Marianna B., Parikh, Parag J., Narra, Vamsi R., Fowler, Kathryn J., Doyle, Majella B., Chapman, William C., Strasberg, Steven S., Hawkins, William G., and Fields, Ryan C.

Published
2017
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14. In Silico Epitope Prediction Analyses Highlight the Potential for Distracting Antigen Immunodominance with Allogeneic Cancer Vaccines

Author

James, C. Alston, primary, Ronning, Peter, additional, Cullinan, Darren, additional, Cotto, Kelsy C., additional, Barnell, Erica K., additional, Campbell, Katie M., additional, Skidmore, Zachary L., additional, Sanford, Dominic E., additional, Goedegebuure, S. Peter, additional, Gillanders, William E., additional, Griffith, Obi L., additional, Hawkins, William G., additional, and Griffith, Malachi, additional

Published
2021
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17. A 22-year experience with pancreatic resection for metastatic renal cell carcinoma

Author

Anderson, Blaire, primary, Williams, Gregory A., additional, Sanford, Dominic E., additional, Liu, Jingxia, additional, Dageforde, Leigh A., additional, Hammill, Chet W., additional, Fields, Ryan C., additional, Hawkins, William G., additional, Strasberg, Steven M., additional, Doyle, Majella B., additional, Chapman, William C., additional, and Khan, Adeel S., additional

Published
2020
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18. Long term exocrine and endocrine function after pancreatectomy

Author

Anderson, Blaire, primary, Kusakabe, Jiro, additional, Liu, Jingxia, additional, Williams, Greg, additional, Chapman, William C., additional, Doyle, Majella M.B., additional, Khan, Adeel S., additional, Sanford, Dominic E., additional, Hammill, Chet W., additional, Strasberg, Steven M., additional, Hawkins, William G., additional, and Fields, Ryan C., additional

Published
2018
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20. Are readmission rates on a neurosurgical service indicators of quality of care?

Author

Shah, Manish N., Stoev, Ivan T., Sanford, Dominic E., Gao, Feng, Santiago, Paul, Jaques, David P., and Dacey, Ralph G.

Subjects
Adult, Aged, 80 and over, Male, Time Factors, Adolescent, Neurosurgery, Length of Stay, Middle Aged, Patient Readmission, Article, Neurosurgical Procedures, Humans, Female, Aged, Quality of Health Care
Abstract

The goal of this study was to examine the reasons for early readmissions within 30 days of discharge to a major academic neurosurgical service.A database of readmissions within 30 days of discharge between April 2009 and September 2010 was retrospectively reviewed. Clinical and administrative variables associated with readmission were examined, including age, sex, race, days between discharge and readmission, and insurance type. The readmissions were then assigned independently by 2 neurosurgeons into 1 of 3 categories: scheduled, adverse event, and unrelated. The adverse event readmissions were further subcategorized into patients readmitted although best practices were followed, those readmitted due to progression of their underlying disease, and those readmitted for preventable causes. These variables were compared descriptively.A total of 348 patients with 407 readmissions were identified, comprising 11.5% of the total 3552 admissions. The median age of readmitted patients was 55 years (range 16-96 years) and patients older than 65 years totaled 31%. There were 216 readmissions (53% of 407) for management of an adverse event that was classified as either preventable (149 patients; 37%) or unpreventable (67 patients; 16%). There were 113 patients (28%) who met readmission criteria but who were having an electively scheduled neurosurgical procedure. Progression of disease (48 patients; 12%) and treatment unrelated to primary admission (30 patients; 7%) were additional causes for readmission. There was no significant difference in the proportion of early readmissions by payer status when comparing privately insured patients and those with public or no insurance (p = 0.09).The majority of early readmissions within 30 days of discharge to the neurosurgical service were not preventable. Many of these readmissions were for adverse events that occurred even though best practices were followed, or for progression of the natural history of the neurosurgical disease requiring expected but unpredictably timed subsequent treatment. Judicious care often requires readmission to prevent further morbidity or death in neurosurgical patients, and penalties for readmission will not change these patient care obligations.

Published
2013

22. Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis

Author

Sanford, Dominic E., primary, Belt, Brian A., additional, Panni, Roheena Z., additional, Mayer, Allese, additional, Deshpande, Anjali D., additional, Carpenter, Danielle, additional, Mitchem, Jonathan B., additional, Plambeck-Suess, Stacey M., additional, Worley, Lori A., additional, Goetz, Brian D., additional, Wang-Gillam, Andrea, additional, Eberlein, Timothy J., additional, Denardo, David G., additional, Goedegebuure, Simon Peter, additional, and Linehan, David C., additional

Published
2013
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23. Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

Author

Mitchem, Jonathan B., primary, Brennan, Donal J., additional, Knolhoff, Brett L., additional, Belt, Brian A., additional, Zhu, Yu, additional, Sanford, Dominic E., additional, Belaygorod, Larisa, additional, Carpenter, Danielle, additional, Collins, Lynne, additional, Piwnica-Worms, David, additional, Hewitt, Stephen, additional, Udupi, Girish Mallya, additional, Gallagher, William M., additional, Wegner, Craig, additional, West, Brian L., additional, Wang-Gillam, Andrea, additional, Goedegebuure, Peter, additional, Linehan, David C., additional, and DeNardo, David G., additional

Published
2013
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24. Abstract B83: Targeting tumor-infiltrating macrophages decreases pancreatic tumor-initiating cells and improves chemotherapeutic responses by relieving immune suppression.

Author

Mitchem, Jonathan B., primary, Brennan, Donal J., additional, Sanford, Dominic E., additional, Knolhoff, Brett L., additional, Zhu, Yu, additional, Brian, Belt, additional, Wang-Gillam, Andrea, additional, Goedegebuure, Peter, additional, Linehan, David C., additional, and DeNardo, David G., additional

Published
2013
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26. The impact of recent hospitalization on surgical site infection after a pancreatectomy.

Author

Sanford DE, Strasberg SM, Hawkins WG, and Fields RC

Subjects
California epidemiology, Female, Follow-Up Studies, Hospitalization economics, Humans, Length of Stay economics, Male, Middle Aged, Morbidity trends, Retrospective Studies, Risk Factors, Surgical Wound Infection economics, Surgical Wound Infection epidemiology, Time Factors, Hospital Costs trends, Hospitalization trends, Pancreatectomy adverse effects, Surgical Wound Infection etiology
Abstract

Background: Surgical site infections (SSI) are a major cause of increased morbidity and cost after a pancreatectomy. Patients undergoing a pancreatectomy frequently have had recent inpatient hospital admissions prior to their surgical admission (recent pre-surgical admission, RPSA), which could increase the risk of SSI., Methods: The 2009-2011 Healthcare Cost Utilization Project California State Inpatient Database was used. Chi-square tests, Student's t-tests and multivariable logistic regression were used., Results: Three thousand three hundred and seventy-six patients underwent a pancreatectomy, and 444 (13.2%) had RPSA. One hundred and eighty (40.5%) RPSAs were to different hospitals other than where patients' pancreatectomy took place. In univariate analysis, patients with RPSA had a significantly higher rate of post-operative SSIs, and this was associated with a longer length of post-operative stay, higher post-operative hospital costs and increased postoperative 30-day readmission rates (Table 1). In Multivariate analysis, RPSA was an independent predictor of post-operative SSI [odds ratio (OR) = 1.68, P = 0.013], and the risk of SSI increased with increasing RPSA length of stay (OR = 1.07 per day, P = 0.001)., Conclusions: Recent pre-surgical admission is an important risk factor for SSI after a pancreatectomy. Many patients with RPSA are not admitted pre-operatively to the same hospital where the pancreatectomy occurs; in such circumstances, SSI rates may not be a sole reflection of the care provided by operating hospitals., (© 2015 International Hepato-Pancreato-Biliary Association.)

Published
2015
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27. Improved peri-operative outcomes with epidural analgesia in patients undergoing a pancreatectomy: a nationwide analysis.

Author

Sanford DE, Hawkins WG, and Fields RC

Subjects
Aged, Chi-Square Distribution, Cost Savings, Databases, Factual, Female, Hospital Costs, Hospital Mortality, Humans, Length of Stay, Linear Models, Logistic Models, Male, Middle Aged, Multivariate Analysis, Postoperative Complications diagnosis, Postoperative Complications economics, Postoperative Complications mortality, Propensity Score, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, United States, Analgesia, Epidural adverse effects, Analgesia, Epidural economics, Analgesia, Epidural mortality, Pancreatectomy adverse effects, Pancreatectomy economics, Pancreatectomy mortality, Postoperative Complications prevention & control
Abstract

Background: In spite of limited evidence demonstrating a benefit, epidural analgesia (EA) is often used for patients undergoing a pancreatectomy. In the present study, the impact of epidural analgesia on post-operative outcomes after a pancreatectomy is examined., Methods: Utilizing the Nationwide Inpatient Sample, the effect of EA on peri-operative outcomes after a pancreatectomy was examined. Multivariable logistic and linear regression with propensity score matching were utilized for risk adjustment., Results: From 2008-2011, 12,440 patients underwent a pancreatectomy. Of these, 1130 (9.1%) patients received epidural analgesia. Using univariate comparison, patients receiving EA had a significantly decreased length of stay (LOS), hospital charges and post-operative inpatient mortality. In multivariate analyses, EA was independently associated with a decreased post-operative LOS (adjusted mean difference = -1.19 days, P < 0.001), decreased hospital charges (adjusted mean difference = -$16,814, P = 0.002) and decreased post-operative inpatient mortality [adjusted odds ratio (OR) = 0.42, P < 0.001]. Using 1:1 propensity score matching, patients who received an EA (n = 1070) had significantly decreased post-operative LOS (11.0 versus 12.1 days, P = 0.011), lower hospital charges ($112,086 versus $128,939, P = 0.001) and decreased post-operative inpatient mortality (1.5% versus 3.6%, P = 0.002) compared with matched controls without EA (n = 1070)., Conclusion: Analysis of a large hospital database reveals that EA is associated with improved peri-operative outcomes after a pancreatectomy. Additional studies are required to understand fully if this relationship is causal., (© 2015 International Hepato-Pancreato-Biliary Association.)

Published
2015
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