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8 results on '"Sarah Hinds"'

1. Systemic inflammatory markers of persistent cerebral edema after aneurysmal subarachnoid hemorrhage

Author

Sung-Ho Ahn, Angela Burkett, Atzhiry Paz, Jude P. Savarraj, Sarah Hinds, Georgene Hergenroeder, Aaron M. Gusdon, Xuefeng Ren, Jeong-Ho Hong, and Huimahn A. Choi

Subjects
Subarachnoid hemorrhage, Cerebral edema, Cytokine, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Cerebral edema (CE) at admission is a surrogate marker of ‘early brain injury’ (EBI) after subarachnoid hemorrhage (SAH). Only recently has the focus on the changes in CE after SAH such as delayed resolution or newly developed CE been examined. Among several factors, an early systemic inflammatory response has been shown to be associated with CE. We investigate inflammatory markers in subjects with early CE which does not resolve, i.e., persistent CE after SAH. Methods Computed tomography scans of SAH patients were graded at admission and at 7 days after SAH for CE using the 0–4 ‘subarachnoid hemorrhage early brain edema score’ (SEBES). SEBES ≤ 2 and SEBES ≥ 3 were considered good and poor grade, respectively. Serum samples from the same subject cohort were collected at 4 time periods (at

Published
2022
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4. English Medieval Probate Inventories

Author

Sarah Hinds

Subjects
narratology, material culture, household objects, domestic spaces, medieval inventories, narratives, History (General) and history of Europe
Abstract

Taking English medieval probate inventories as a case study this article introduces a methodological approach to inventories adapted from the narratological frameworks of Gérard Genette. Using this novel methodology this study explores how we might identify narrative elements within inventories and in so doing better our understanding of the objects and spaces of late medieval houses. It outlines how legal frameworks, the inventorying genre, and the organizational techniques of individual appraisers contributed to processes of narrativization. Moreover, it demonstrates how in praxis this narratological approach can recover traces of hidden objects, spaces, and the movement of appraisers, which have been preserved within the text of these documents. Finally, it highlights the potential of this methodology to be adapted in future work in order to examine systems of classification employed by appraisers, or the contexts of production for inventory corpora.

Published
2022
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5. Leucine-Rich Alpha-2-Glycoprotein 1 is a Systemic Biomarker of Early Brain Injury and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

Author

Jude P. J. Savarraj, Devin W. McBride, Eunsu Park, Sarah Hinds, Atzhiry Paz, Aaron Gusdon, Ren Xuefang, Sheng Pan, Hilda Ahnstedt, Gabriela Delevati Colpo, Eunhee Kim, Zhongming Zhao, Louise McCullough, and Huimahn Alex Choi

Subjects
Neurology (clinical), Critical Care and Intensive Care Medicine, Article
Abstract

BACKGROUND: After subarachnoid hemorrhage (SAH), early brain injury (EBI) and delayed cerebral ischemia (DCI) lead to poor outcomes. Discovery of biomarkers indicative of disease severity and predictive of DCI is important. We tested whether leucine-rich alpha-2-glycoprotein 1 (LRG1) is a marker of severity, DCI, and functional outcomes after SAH. METHODS: We performed untargeted proteomics using mass spectrometry in plasma samples collected at < 48 h of SAH in two independent discovery cohorts (n = 27 and n = 45) and identified LRG1 as a biomarker for DCI. To validate our findings, we used enzyme-linked immunosorbent assay and confirmed this finding in an internal validation cohort of plasma from 72 study participants with SAH (22 DCI and 50 non-DCI). Further, we investigated the relationship between LRG1 and markers of EBI, DCI, and poor functional outcomes (quantified by the modified Rankin Scale). We also measured cerebrospinal fluid (CSF) levels of LRG1 and investigated its relationship to EBI, DCI, and clinical outcomes. RESULTS: Untargeted proteomics revealed higher plasma LRG1 levels across EBI severity and DCI in both discovery cohorts. In the validation cohort, the levels of LRG1 were higher in the DCI group compared with the non-DCI group (mean (SD): 95 [44] vs. 72 [38] pg/ml, p < 0.05, Student’s t-test) and in study participants who proceeded to have poor functional outcomes (84 [39.3] vs. 72 [43.2] pg/ml, p < 0.05). Elevated plasma LRG1 levels were also associated with markers of EBI. However, CSF levels of LRG1 were not associated with EBI severity or the occurrence of DCI. CONCLUSIONS: Plasma LRG1 is a biomarker for EBI, DCI, and functional outcomes after SAH. Further studies to elucidate the role of LRG1 in the pathophysiology of SAH are needed.

Published
2022

8. Markers of brain and endothelial Injury and inflammation are acutely and sex specifically regulated in SARS-CoV-2 infection

Author

Jude Savarraj, Eun S. Park, Gabriela Copo, Sarah Hinds, Diego Morales, Hilda Ahnstedt, Atzhiry Paz, Andres Assing, Shivanki Juneja, Eunhee Kim, Sung-min Cho, Aaron Gusdon, Pramod Dash, Louise McCullough, and H Alex Choi

Subjects
Oncology, medicine.medical_specialty, business.industry, medicine.medical_treatment, Inflammation, Systemic inflammation, Interleukin 10, Cytokine, Interleukin 1 receptor antagonist, Internal medicine, Cohort, medicine, Tumor necrosis factor alpha, Interleukin 8, medicine.symptom, business
Abstract

ObjectiveTo investigate brain injury markers (BIM), endothelial injury markers (EIM) and cytokine/chemokine (CC) markers of systemic inflammation in coronavirus disease 2019 (COVID-19) and across sex.MethodsPlasma samples from 57 subjects at ResultsThree BIMs: MAP2, NSE and S100B, two EIMs: sICAM1 and sVCAM1 and seven CCs: GRO IL10, sCD40L, IP10, IL1Ra, MCP1 and TNFα were significantly (pConclusionThe acute elevation of BIMs, CCs, and EIMs and the robust associations among them at COVID-19 hospitalization suggest that brain injury is mediated by endotheliopathy and inflammation. Higher BIM and inflammatory markers in men additionally suggest that men are more susceptible to the risk compared to women.

Published
2021
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