Search

Your search keyword '"Sato, Fuminori"' showing total 169 results
Start Over Author "Sato, Fuminori" Search Limiters Available in Library Collection
169 results on '"Sato, Fuminori"'

6. Effect of Renal Impairment on the Pharmacokinetics of Memantine

Author

Moritoyo, Takashi, Hasunuma, Tomoko, Harada, Kazuhiro, Tateishi, Tomonori, Watanabe, Makoto, Kotegawa, Tsutomu, Nagai, Masahiro, Kumagai, Yuji, Fujitani, Tomomichi, Okura, Takahumi, Fukuoka, Tomikazu, Miyoshi, Kenichi, Matsuura, Bunzo, Furukawa, Shinya, Kobori, Tomoe, Moritoyo, Hiroyoko, Nishikawa, Noriko, Tsujii, Tomoaki, Iwaki, Hirotaka, Nakamura, Masahiko, Makino, Satoshi, Ohnuma, Kei, Yuji, Koichiro, Hashimoto, Megumi, Takasu, Masaru, Hashizume, Yutaka, You, Koji, Matsumura, Tomoko, Tanaka, Yuji, Matsumoto, Nahoko, Nakamura, Junichi, Miura, Jun, Akizawa, Tadao, Kitazawa, Kozo, Shibata, Takanori, Kuroki, Aki, Honda, Hirokazu, Mukai, Masanori, Ohashi, Kyoichi, Morimoto, Takuya, Imai, Hiromitsu, Okudaira, Toshiaki, Sato, Fuminori, Imanaga, Junko, Tanaka, Katsuhiro, and Nomoto, Masahiro

Published
2012
Full Text
View/download PDF

7. A Clinical Case of Insulinoma Presenting with Postprandial Hypoglycemia in a Patient with a History of Gastric Bypass Surgery

Author

Hayashida, Ryosuke, primary, Tsuchiya, Kyoichiro, additional, Sekine, Tetsuo, additional, Momose, Takashi, additional, Sato, Fuminori, additional, Sakurada, Maya, additional, Nishida, Kenji, additional, Hayashi, Tatsuya, additional, Morita, Yasuhiro, additional, Okada, Haruka, additional, Fukushima, Noriyoshi, additional, Yamada, Tetsuya, additional, and Tsujino, Motoyoshi, additional

Published
2022
Full Text
View/download PDF

9. CLP1 links tRNA metabolism to progressive motor-neuron loss

Author

Hanada, Toshikatsu, Weitzer, Stefan, Mair, Barbara, Bernreuther, Christian, Wainger, Brian J., Ichida, Justin, Hanada, Reiko, Orthofer, Michael, Cronin, Shane J., Komnenovic, Vukoslav, Minis, Adi, Sato, Fuminori, Mimata, Hiromitsu, Yoshimura, Akihiko, Tamir, Ido, Rainer, Johannes, Kofler, Reinhard, Yaron, Avraham, Eggan, Kevin C., Woolf, Clifford J., Glatze, Markus, Herbst, Ruth, Martinez, Javier, and Penninger, Josef M.

Subjects
Neuromuscular diseases -- Research, Motor neurons -- Observations, Phosphotransferases -- Properties, Transfer RNA -- Observations, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clpl ([Clp1.sup.K/K]) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of neuromuscular junctions, resulting in impaired motor function, muscle weakness, paralysis and fatal respiratory failure. Transgenic rescue experiments show that CLP1 functions in motor neurons. Mechanistically, loss of CLP1 activity results in accumulation of a novel set of small RNA fragments, derived from aberrant processing of tyrosine pre-transfer RNA. These tRNA fragments sensitize cells to oxidative-stress-induced p53 (also known as TRP53) activation and p53-dependent cell death. Genetic inactivation of p53 rescues [Clp1.sup.K/K] mice from the motor neuron loss, muscle denervation and respiratory failure. Our experiments uncover a mechanistic link between tRNA processing, formation of a new RNA species and progressive loss of lower motor neurons regulated by p53., RNA molecules undergo co- and post-transcriptional processing, leading to mature, functional RNAs. In mammals and archaea CLP1 proteins are kinases that phosphorylate the 5' hydroxyl ends of RNA (1-3). Human [...]

Published
2013
Full Text
View/download PDF

11. Genomic profiling of renal cell carcinoma in patients with end-stage renal disease

Author

Inoue, Toru, Matsuura, Keiko, Yoshimoto, Taichiro, Nguyen, Lam Tung, Tsukamoto, Yoshiyuki, Nakada, Chisato, Hijiya, Naoki, Narimatsu, Takahiro, Nomura, Takeo, Sato, Fuminori, Nagashima, Yoji, Kashima, Kenji, Hatakeyama, Shingo, Ohyama, Chikara, Numakura, Kazuyuki, Habuchi, Tomonori, Nakagawa, Masayuki, Seto, Masao, Mimata, Hiromitsu, and Moriyama, Masatsugu

Published
2012
Full Text
View/download PDF

17. Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma

Author

Matsuura Keiko, Nakada Chisato, Mashio Mizuho, Narimatsu Takahiro, Yoshimoto Taichiro, Tanigawa Masato, Tsukamoto Yoshiyuki, Hijiya Naoki, Takeuchi Ichiro, Nomura Takeo, Sato Fuminori, Mimata Hiromitsu, Seto Masao, and Moriyama Masatsugu

Subjects
Clear cell renal cell carcinoma, SAV1, Hippo pathway, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Clinical outcome of patients with high-grade ccRCC (clear cell renal cell carcinoma) remains still poor despite recent advances in treatment strategies. Molecular mechanism of pathogenesis in developing high-grade ccRCC must be clarified. In the present study, we found that SAV1 was significantly downregulated with copy number loss in high-grade ccRCCs. Therefore, we investigated the SAV1 function on cell proliferation and apoptosis in vitro. Furthermore, we attempted to clarify the downstream signaling which is regulated by SAV1. Methods We performed array CGH and gene expression analysis of 8 RCC cell lines (786-O, 769-P, KMRC-1, KMRC-2, KMRC-3, KMRC-20, TUHR4TKB, and Caki-2), and expression level of mRNA was confirmed by quantitative RT-PCR (qRT-PCR) analysis. We next re-expressed SAV1 in 786-O cells, and analyzed its colony-forming activity. Then, we transfected siRNAs of SAV1 into the kidney epithelial cell line HK2 and renal proximal tubule epithelial cells (RPTECs), and analyzed their proliferation and apoptosis. Furthermore, the activity of YAP1, which is a downstream molecule of SAV1, was evaluated by western blot analysis, reporter assay and immunohistochemical analysis. Results We found that SAV1, a component of the Hippo pathway, is frequently downregulated in high-grade ccRCC. SAV1 is located on chromosome 14q22.1, where copy number loss had been observed in 7 of 12 high-grade ccRCCs in our previous study, suggesting that gene copy number loss is responsible for the downregulation of SAV1. Colony-forming activity by 786-O cells, which show homozygous loss of SAV1, was significantly reduced when SAV1 was re-introduced exogenously. Knockdown of SAV1 promoted proliferation of HK2 and RPTEC. Although the phosphorylation level of YAP1 was low in 786-O cells, it was elevated in SAV1-transduced 786-O cells. Furthermore, the transcriptional activity of the YAP1 and TEAD3 complex was inhibited in SAV1-transduced 786-O cells. Immunohistochemistry frequently demonstrated nuclear localization of YAP1 in ccRCC cases with SAV1 downregulation, and it was preferentially detected in high-grade ccRCC. Conclusions Taken together, downregulation of SAV1 and the consequent YAP1 activation are involved in the pathogenesis of high-grade ccRCC. It is an attractive hypothesis that Hippo signaling could be candidates for new therapeutic target.

Published
2011
Full Text
View/download PDF

21. Integrated Simulation of the Atomization Process of a Liquid Jet Through a Cylindrical Nozzle

Author

Ishimoto, Jun, Hoshina, Hidehiro, Tsuchiyama, Tadashi, Watanabe, Hideyuki, Haga, Asako, and Sato, Fuminori

Subjects
Physics::Fluid Dynamics, Physics::Atomic and Molecular Clusters
Abstract

The 3-D structure of liquid atomization behavior through a cylindrical nozzle is numerically investigated and visualized by a new type of integrated simulation technique. CFD (Computational Fluid Dynamics) analysis focused on the consecutive breakup of a liquid column, formation of liquid film, and generation of droplets of a cylindrical flow in the outlet section of the nozzle. Utilizing the governing equations for high-speed atomizing nozzle flow based on the LES-VOF model in conjunction with the CSF model, an integrated parallel computation is performed to clarify the detailed atomization process of a cylindrical nozzle flow and to acquire data, which is difficult to confirm by experiment, such as atomization length, liquid core shape, distribution droplet sizes, spray angle and droplet velocity profiles. According to the present analysis, the atomization rate and the droplets-gas two-phase flow characteristics are found to be controlled by the turbulence perturbation upstream of the injector nozzle, hydrodynamic instabilities at the gas-liquid interface, and shear stresses between the liquid core and periphery of the jet.

Published
2007

23. Downregulation ofWDR 20due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma

Author

Takahashi, Mika, primary, Tsukamoto, Yoshiyuki, additional, Kai, Tomoki, additional, Tokunaga, Akinori, additional, Nakada, Chisato, additional, Hijiya, Naoki, additional, Uchida, Tomohisa, additional, Daa, Tsutomu, additional, Nomura, Takeo, additional, Sato, Fuminori, additional, Mimata, Hiromitsu, additional, Matsuura, Keiko, additional, and Moriyama, Masatsugu, additional

Published
2016
Full Text
View/download PDF

24. Lymphoepithelioma-Like Carcinoma of the Bladder: A Case Report and Review of the Literature

Author

Mori, Kenichi, Ando, Tadasuke, Nomura, Takeo, Sato, Fuminori, and Mimata, Hiromitsu

Subjects
Article Subject, urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

Lymphoepithelioma-like carcinoma (LELC) in the bladder is uncommon with a reported incidence of 0.4%–1.3% of all bladder carcinomas. In Japan, some occurrences of LELC have been reported in the renal pelvis and ureter but only two in the bladder. A bladder tumor was identified in a 70-year-old man suffering from macroscopic hematuria for 2 months. Sections of the transurethral tumor resection showed invasive high-grade urothelial carcinoma. The patient was diagnosed with local invasive bladder tumor, and cystectomy with ileal conduit formation was performed. The final pathological evaluation was predominant LELC with urothelial carcinoma. We present a new case of LELC in the bladder and performed a review of all published cases of LELC in the urinary tract to obtain its characteristics and prognostic guide.

Published
2013
Full Text
View/download PDF

25. Uretero-Internal Pudendal Artery Fistula with Longterm Indwelling of Ureteral Stent: A Case Report

Author

Yuki, Hideo, Takayama, Yasuhiro, Takuma, Masahisa, Takahashi, Mika, Ando, Tadasuke, Sumino, Yasuhiro, Nomura, Takeo, Sato, Fuminori, and Mimata, Hiromitsu

Subjects
Article Subject, urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

A 74-year-old woman presenting with bilateral ureteral stricture was referred to our hospital. She had undergone radical hysterectomy and adjuvant irradiation therapy for cervical cancer in 2000. Double-J stents were inserted in both the ureters and replaced at regular intervals. Eighteen months after ureteral stenting, she complained of gross hematuria and was managed with hemostatic agents. During a routine replacement of the right double-J stent, massive bleeding was observed from the urethra which continued intermittently. The source of bleeding was not identified on computed tomography and angiography. We kept her at rest, which reduced the bleeding. However, she required intermittent transfusions. Angiography was performed at the time of bleeding on March 5, 2011. A uretero-internal pudendal artery fistula was found, and coil embolization was performed. Thereafter, hematuria did not recur up to the last followup in July 2011.

Published
2012
Full Text
View/download PDF

26. Tumor-to-Tumor Metastasis to Chromophobe Renal Cell Carcinoma: A First Report

Author

Shin, Toshitaka, Kan, Tomoko, Sato, Fuminori, and Mimata, Hiromitsu

Subjects
Article Subject
Abstract

Tumor-to-tumor metastasis is a rare phenomenon. From our review of the international literature, around 150 cases have been reported since it was first documented by Campbel in 1868. Renal clear cell carcinoma is well known to be the most common recipient of tumor-to-tumor metastasis in all tumors. However, renal chromophobe cell carcinoma has not been reported to be a recipient. Here, we report a first case of colorectal carcinoma metastatic to chromophobe renal cell carcinoma.

Published
2011
Full Text
View/download PDF

27. Left Transperitoneal Adrenalectomy with a Laparoendoscopic Single-Site Surgery Combined Technique: Initial Case Reports

Author

Sumino, Yasuhiro, Nakano, Daisaku, Mori, Ken-Ichi, Nomura, Takeo, Sato, Fuminori, and Mimata, Hiromitsu

Subjects
Article Subject
Abstract

Laparoendoscopic single-site surgery (LESS) is a step toward the development of minimally invasive surgery. It is initially difficult for surgeons with limited experience to perform the surgery. We describe two cases of left adrenalectomy with a LESS combined with the addition of an accessory port. After a 2.5-cm skin incision was made at the level of the paraumbilicus to insert the primary 12-mm trocar for the laparoscope, a 5-mm nonbladed trocar was placed through the skin incision side-by-side with the primary trocar. A second 3-mm nonbladed trocar was then placed along the anterior axillary line; a multichannel trocar was not used as a single port. Both adrenalectomies were completed successfully. In patients with a minor adrenal tumor, a combined technique using LESS and an additional port is easier than LESS alone and may, therefore, be a bridge between the conventional laparoscopic approach and LESS.

Published
2011
Full Text
View/download PDF

28. Laparoendoscopic Single-Site (LESS) Retroperitoneal Radical Nephrectomy in a Patient with Renal Cell Carcinoma Receiving Hemodialysis

Author

Nomura, Takeo, Sato, Fuminori, Takahashi, Mika, Sumino, Yasuhiro, and Mimata, Hiromitsu

Subjects
Article Subject
Abstract

We present here the patient undergoing laparoendoscopic single-site (LESS) retroperitoneal radical nephrectomy while receiving hemodialysis. An 81-year-old man under hemodialysis for 6 years was incidentally discovered to have two left renal masses with acquired cystic disease of the kidney (ACDK). A 4-cm flank incision for GelPort was made. Three trocars were inserted into the retroperitoneum through GelPort. After division of the renal vessels and ureter, the kidney was placed into the extraction bag and was retrieved through flank incision without any extra skin incision. There were no intraoperative and postoperative complications. This procedure offers an effective, minimally invasive therapeutic alternative to the standard laparoscopic technique in high-risk end-stage renal disease patients.

Published
2011
Full Text
View/download PDF

35. Downregulation of NDUFB 6 due to 9p24.1‐p13.3 loss is implicated in metastatic clear cell renal cell carcinoma

Author

Narimatsu, Takahiro, primary, Matsuura, Keiko, additional, Nakada, Chisato, additional, Tsukamoto, Yoshiyuki, additional, Hijiya, Naoki, additional, Kai, Tomoki, additional, Inoue, Toru, additional, Uchida, Tomohisa, additional, Nomura, Takeo, additional, Sato, Fuminori, additional, Seto, Masao, additional, Takeuchi, Ichiro, additional, Mimata, Hiromitsu, additional, and Moriyama, Masatsugu, additional

Published
2014
Full Text
View/download PDF

36. Roles of Neuregulin, an ErbB ligand, in the maintenance of muscles

Author

Sehara-Fujisawa, Atsuko, Sato, Fuminori, Sato, Tomomi, and Iida, Atsuo

Abstract

第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス), The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan), Maintenance of skeletal muscle requires responses to mechanicals stresses caused by stretch of muscles, which was demonstrated by effects of exercise and gravity. The stress responses include factors intrinsic to muscle and extrinsic ones. The formers include IGF-1, and the latters include membrane-anchored Neuregulin/ARIA (acetylcholine receptor inducing activity) generated in neuronal cells. Some of ADAM (A Disintegrin And Metalloprotease) family proteases modulate the ectodomain shedding of various membrane proteins, such as membrane-anchored growth factors. Meltrin beta(ADAM19) is expressed in the peripheral nervous system, and mediates the ectodomain shedding of Neuregulin. We report here roles of Meltrin beta in the formation of the NMJ. The zone of acetylcholine receptor a mRNA distribution was broader and excess sprouting of motor nerve terminals was more prominent in Meltrin beta deficient than in wild-type embryonic diaphragms, suggesting roles of Meltrin beta in the regulation of Neuregulin. Neuregulin has various isoforms including Type I, II, and III. We isolated cDNAs encoding these three isoforms from zebrafish (Danio rerio). In situ hybridization revealed temporally and spatially regulated expression of each Neuregulin isoform during development. Moreover, we found that swimming caused dramatic upregulated expression of Neuregulin, suggesting that this gene is sensitive to stress. We are currently trying to clarify roles of Neuregulin in zebrafish muscle and nervous system by injecting morpholino oligonucleotides against each form of Neuregulin., 形態: カラー図版あり, 資料番号: AA0064297046

Published
2009

41. Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma.

Author

Takahashi, Mika, Tsukamoto, Yoshiyuki, Kai, Tomoki, Tokunaga, Akinori, Nakada, Chisato, Hijiya, Naoki, Uchida, Tomohisa, Daa, Tsutomu, Nomura, Takeo, Sato, Fuminori, Mimata, Hiromitsu, Matsuura, Keiko, and Moriyama, Masatsugu

Abstract

Previously, we reported that genomic loss of 14q occurs more frequently in high-grade than in low-grade clear cell renal cell carcinomas (cc RCCs), and has a significant impact on the levels of expression of genes located in this region, suggesting that such genes may be involved in the malignant transformation of cc RCCs. Here, we found that six of the genes located in the minimal common region of 14q loss were significantly downregulated in high-grade cc RCCs due to copy number loss. Using a dataset from The Cancer Genome Atlas Research Network, we found that downregulation of one of these six genes, WDR20, was significantly associated with poorer outcome in patients with cc RCC, suggesting that WDR20 downregulation may be involved in the malignant transformation of cc RCCs. In functional assays, exogenous WDR20 significantly inhibited the growth of RCC cell lines and induced apoptosis. Interestingly, the phosphorylation levels of ERK and protein kinase B/AKT, which reportedly contribute to the malignant phenotype of RCC cells, were clearly reduced by exogenous expression of WDR20. Thus, our data suggest that downregulation of WDR20 due to 14q loss may be involved in the malignant transformation of cc RCCs, in part through activation of the ERK and protein kinase B/AKT pathways. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

45. Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma.

Author

Narimatsu, Takahiro, Matsuura, Keiko, Nakada, Chisato, Tsukamoto, Yoshiyuki, Hijiya, Naoki, Kai, Tomoki, Inoue, Toru, Uchida, Tomohisa, Nomura, Takeo, Sato, Fuminori, Seto, Masao, Takeuchi, Ichiro, Mimata, Hiromitsu, and Moriyama, Masatsugu

Subjects
ONCOGENES, RENAL cell carcinoma, DOWNREGULATION, METASTASIS, GENE expression, ONCOLOGY
Abstract

This study was conducted to clarify the genomic profiles of metastatic clear cell renal cell carcinomas (ccRCCs) and identify the genes responsible for development of metastasis. We analyzed the genomic profiles of 20 cases of primary ccRCC and their corresponding metastases using array-based comparative genomic hybridization, and identified 32 chromosomal regions in which gene copy number alterations were detected more frequently in metastases than in the primary tumors. Among these 32 regions, 9p24.1-p13.3 loss was the most statistically significant alteration. Furthermore, we found that patients with 9p24.1-p13.3 loss in primary tumors exhibited significantly lower rates of recurrence-free and cancer-specific survival, suggesting that 9p loss in the primary tumor is a potential biomarker predicting early recurrence of metastasis. Interestingly, the genomic profiles of primary tumors with 9p loss resembled those of their corresponding metastases, though 9p loss was accumulated in the metastases derived from the primary tumors without 9p loss. Comparison of the mRNA expression levels revealed that 2 of 58 genes located at 9p24.1-p13.3 were downregulated due to gene copy number loss in ccRCCs. An overexpression study of these two genes in ccRCC cell lines revealed that downregulation of NDUFB6 due to loss at 9p24.1-p13.3 may confer a growth advantage on metastatic ccRCC cells. These results were confirmed by analyzing the data of 405 cases of ccRCC obtained from The Cancer Genome Atlas (TCGA). On the basis of our present data, we propose that NDUFB6 is a possible tumor suppressor of metastatic ccRCCs. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results