44 results on '"Satoko Shimizu"'
Search Results
2. A Case of Guillain-Barré Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrosis Overlap After Pembrolizumab Treatment
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Tomoyo Oguri MD, PhD, Shinji Sasada MD, PhD, Satoko Shimizu MD, Risa Shigematsu MD, Yumi Tsuchiya MD, Kota Ishioka MD, Saeko Takahashi MD, PhD, Koichi Oki MD, PhD, Yoshifumi Kimura MD, PhD, Reishi Seki MD, Shigemichi Hirose MD, PhD, and Morio Nakamura MD, PhD
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Medicine (General) ,R5-920 ,Pathology ,RB1-214 - Abstract
A 76-year-old man was admitted to our hospital with Guillain-Barré syndrome (GBS), presenting with facial palsy, dysarthria, and dysphagia as Grade 3 immune-related adverse events (irAEs) due to pembrolizumab administration for Stage IV lung adenocarcinoma. Although prednisolone (1 mg/kg) was started for GBS due to the irAE, dark erythema and skin eruptions appeared on the patient’s torso. Then erosion was observed on 18% of the body surface area and skin biopsy was performed. Finally, the patient was diagnosed with Stevens-Johnson syndrome/toxic epidermal necrosis overlap. Intravenous immunoglobulin therapy was started, and the skin symptoms improved, with the erosion becoming epithelial. He died of aspiration pneumonia related to GBS, although his neurological symptoms had improved after steroid and intravenous immunoglobulin therapy. This is the first reported case of pembrolizumab-induced GBS and Stevens–Johnson syndrome/toxic epidermal necrosis overlap. It is necessary to be careful that the possibility of other severe irAEs may occur simultaneously.
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- 2021
- Full Text
- View/download PDF
3. Multiple Nodules Arising within a Birthmark on the Scalp: A Quiz
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Takuya Mizukami, Yasuyuki Fujita, Yuka Maya, Kunihiro Kawashima, Takahiro Tsuji, Eiichi Arai, Koichi Honma, and Satoko Shimizu
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Dermatology ,RL1-803 - Abstract
Abstract is missing (Quiz)
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- 2020
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4. Bullous pemphigoid in a metastatic lung cancer patient associated with nivolumab
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Yuka Maya, MD, Reine Moriuchi, MD, PhD, Yuka Takashima, MD, Moeko Hotta, MD, Hiroshi Izumi, MD, and Satoko Shimizu, MD, PhD
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Bullous pemphigoid ,Nivolumab ,irAEs ,Lung cancer ,Dermatology ,RL1-803 - Published
- 2020
- Full Text
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5. Recalcitrant granuloma faciale with 14-year follow-up
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Keiko Shiba, Reine Moriuchi, Yusuke Morita, Yohei Hamade, Toshinari Miyauchi, Kazuhiro Kikuchi, Kikuo Tsuchiya, and Satoko Shimizu
- Subjects
GF ,Granuloma faciale ,PSL ,Dermatology ,RL1-803 - Abstract
Granuloma faciale (GF) is an uncommon inflammatory dermatosis that is characterized by one or several asymptomatic brown red nodules or plaques usually occurring on the face. GF is known to be extremely resistant to treatment. Various treatments have been attempted, including topical or intralesional or systemic corticosteroids, dapsone, antimalarials, colchicine, topical tacrolimus, and topical psoralen; however, none of these have been found to be reliably efficacious. We tried numerous combinations and rotations of therapeutic modalities for GF over a long time. We described a case of GF in which the eruptions were carefully observed over the course of 14 years before finally resolving. Our experience suggests that continuous and careful follow-up, and trials of combinations and rotations of therapeutic modalities are essential for treating GF.
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- 2017
- Full Text
- View/download PDF
6. A Case of Guillain-Barré Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrosis Overlap After Pembrolizumab Treatment
- Author
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Morio Nakamura, Reishi Seki, Satoko Shimizu, Kota Ishioka, Tomoyo Oguri, Shinji Sasada, Yoshifumi Kimura, Risa Shigematsu, Shigemichi Hirose, Koichi Oki, Saeko Takahashi, and Yumi Tsuchiya
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Male ,medicine.medical_specialty ,Medicine (General) ,Erythema ,Epidemiology ,Case Report ,Pembrolizumab ,Aspiration pneumonia ,Antibodies, Monoclonal, Humanized ,Guillain-Barre Syndrome ,03 medical and health sciences ,Necrosis ,0302 clinical medicine ,Intravenous Immunoglobulin Therapy ,R5-920 ,medicine ,immune-related adverse event ,Pathology ,Humans ,RB1-214 ,Safety, Risk, Reliability and Quality ,Aged ,toxic epidermal necrosis ,Guillain-Barre syndrome ,medicine.diagnostic_test ,integumentary system ,business.industry ,medicine.disease ,Guillain-Barré syndrome ,Dysphagia ,Dermatology ,030220 oncology & carcinogenesis ,Stevens-Johnson Syndrome ,Skin biopsy ,Prednisolone ,pembrolizumab ,medicine.symptom ,business ,Safety Research ,030217 neurology & neurosurgery ,medicine.drug - Abstract
A 76-year-old man was admitted to our hospital with Guillain-Barré syndrome (GBS), presenting with facial palsy, dysarthria, and dysphagia as Grade 3 immune-related adverse events (irAEs) due to pembrolizumab administration for Stage IV lung adenocarcinoma. Although prednisolone (1 mg/kg) was started for GBS due to the irAE, dark erythema and skin eruptions appeared on the patient’s torso. Then erosion was observed on 18% of the body surface area and skin biopsy was performed. Finally, the patient was diagnosed with Stevens-Johnson syndrome/toxic epidermal necrosis overlap. Intravenous immunoglobulin therapy was started, and the skin symptoms improved, with the erosion becoming epithelial. He died of aspiration pneumonia related to GBS, although his neurological symptoms had improved after steroid and intravenous immunoglobulin therapy. This is the first reported case of pembrolizumab-induced GBS and Stevens–Johnson syndrome/toxic epidermal necrosis overlap. It is necessary to be careful that the possibility of other severe irAEs may occur simultaneously.
- Published
- 2021
7. Numerical Simulation for Compressive Failure of CFRP Laminates with Various Shaped Holes
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Hiroshi Suemasu, Satoko Shimizu, Jun Koyanagi, Mio Sato, and Yasuo Kogo
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Materials science ,Computer simulation ,Compressive failure ,Composite material - Published
- 2019
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8. Establishment of the Embryonic Shoot Meristem Involves Activation of Two Classes of Genes with Opposing Functions for Meristem Activities
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Masako Kamiya, Ryosuke Iwamoto, Seiji Takeda, Masao Tasaka, Yuka Tsubakimoto, Michael Lenhard, Rezaul Karim, Hiroyuki Ogisu, Mitsuhiro Aida, Masaharu Mizutani, and Satoko Shimizu
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0106 biological sciences ,0301 basic medicine ,Plant embryogenesis ,Arabidopsis ,STM ,CUC ,01 natural sciences ,KLU ,lcsh:Chemistry ,Cytochrome P-450 Enzyme System ,Gene Expression Regulation, Plant ,KNAT6 ,lcsh:QH301-705.5 ,Spectroscopy ,transcription factor ,Regulator gene ,Gene Expression Regulation, Developmental ,food and beverages ,General Medicine ,shoot meristem ,Computer Science Applications ,Cell biology ,boundary ,Shoot ,embryogenesis ,BLR ,cytochrome P450 ,Meristem ,Biology ,Catalysis ,Article ,Inorganic Chemistry ,03 medical and health sciences ,CYP78A5 ,Physical and Theoretical Chemistry ,Molecular Biology ,Gene ,Transcription factor ,Homeodomain Proteins ,Arabidopsis Proteins ,Organic Chemistry ,fungi ,Meristem maintenance ,LAS ,Embryonic stem cell ,Repressor Proteins ,stem cell ,LAS ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,010606 plant biology & botany ,Transcription Factors - Abstract
The shoot meristem, a stem-cell-containing tissue initiated during plant embryogenesis, is responsible for continuous shoot organ production in postembryonic development. Although key regulatory factors including KNOX genes are responsible for stem cell maintenance in the shoot meristem, how the onset of such factors is regulated during embryogenesis is elusive. Here, we present evidence that the two KNOX genes STM and KNAT6 together with the two other regulatory genes BLR and LAS are functionally important downstream genes of CUC1 and CUC2, which are a redundant pair of genes that specify the embryonic shoot organ boundary. Combined expression of STM with any of KNAT6, BLR, and LAS can efficiently rescue the defects of shoot meristem formation and/or separation of cotyledons in cuc1 cuc2 double mutants. In addition, CUC1 and CUC2 are also required for the activation of KLU, a cytochrome P450-encoding gene known to restrict organ production, and KLU counteracts STM in the promotion of meristem activity, providing a possible balancing mechanism for shoot meristem maintenance. Together, these results establish the roles for CUC1 and CUC2 in coordinating the activation of two classes of genes with opposite effects on shoot meristem activity.
- Published
- 2020
9. Effects of aromatic ring type on reactions subsequent to the β-O-4 bond cleavage of non-phenolic lignin model compounds under alkaline pulping conditions
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Satoko Shimizu, Yuji Matsumoto, Pattaraporn Posoknistakul, Tomoya Yokoyama, and Takuya Akiyama
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0106 biological sciences ,chemistry.chemical_classification ,Aryl ,Ether ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,0104 chemical sciences ,Biomaterials ,Benzaldehyde ,chemistry.chemical_compound ,chemistry ,010608 biotechnology ,Lignin ,Phenol ,Alkyl ,Bond cleavage ,Acetophenone - Abstract
The reaction products of an alkaline treatment of non-phenolic β-O-4-type lignin model compounds (C6–C2-type) consisting of p-hydroxyphenyl (H), guaiacyl (G), and/or syringyl (S) nuclei were identified and quantified. This was performed to examine how the type of H, G, or S nucleus affect the reaction product profiles. The major identified and quantified reaction products were phenol derivatives that were liberated from the aryl sides of the β-O-4 ether bonds of the lignin model compounds. Other products included derivatives of phenylethane-1,2-diol (glycol-type), benzaldehyde, and acetophenone, which originated from the alkyl sides of the β-O-4 ether bonds of the lignin model compounds. Although the type of aromatic nucleus of the aryl side of the β-O-4 ether bond of the lignin model compounds did not significantly affect the profile of the reaction products, the type of the alkyl side nucleus was influential. The glycol-type compound was the exclusive major reaction product when the S nucleus was on the alkyl side of the β-O-4 ether bond. On the other hand, when the H or G nucleus was present, a benzaldehyde derivative was the other major reaction product.
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- 2018
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10. An extending ulcer at the site of cesarean-section incision
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Satoko Shimizu, Yuka Maya, Takuya Mizukami, and Yasuyuki Fujita
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medicine.medical_specialty ,business.industry ,Section (archaeology) ,Medicine ,Dermatology ,business ,Surgery - Published
- 2021
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11. Bullous pemphigoid in a metastatic lung cancer patient associated with nivolumab
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Hiroshi Izumi, Reine Moriuchi, Moeko Hotta, Satoko Shimizu, Yuka Takashima, and Yuka Maya
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Oncology ,medicine.medical_specialty ,business.industry ,Bullous pemphigoid ,Dermatology ,medicine.disease ,Nivolumab ,Internal medicine ,RL1-803 ,medicine ,irAEs ,Metastatic lung cancer ,Case Letter ,Lung cancer ,business - Published
- 2020
12. A rare case of metastatic skin tumors originating from the sarcomatous component of lung carcinosarcoma
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Reine Moriuchi, Satoko Shimizu, Takahisa Shirato, and Yuka Takashima
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Pathology ,medicine.medical_specialty ,Infectious Diseases ,business.industry ,Rare case ,lcsh:Dermatology ,Medicine ,Lung Carcinosarcoma ,Dermatology ,lcsh:RL1-803 ,business ,Sarcomatous Component - Published
- 2019
13. Rash after consumption of game meat
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Fumihiro Kodama, Yasuyuki Fujita, Satoko Shimizu, and Yuka Maya
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medicine.medical_specialty ,business.industry ,Dermatology department ,Maculopapular rash ,medicine ,Eosinophilia ,General Medicine ,medicine.symptom ,business ,Dermatology ,Rash ,humanities ,Malaise - Abstract
This is a disseminated maculopapular rash due to trichinellosis in a woman in her 50s, secondary to eating undercooked meat (fig 1). She presented at the dermatology department with a 10 day history of pyrexia, eosinophilia, malaise, and abdominal …
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- 2021
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14. Synchronous Multiple Ossifying Tumors of the Digits
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Yuichiro Fukazawa, Kazuhiko Hirachi, Yohei Hamade, Takaya Fukumoto, Mitsuru Yanai, Satoko Shimizu, Takashi Anan, Nobuki Miyamoto, Reine Moriuchi, and Toshinari Miyauchi
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Adult ,Male ,medicine.medical_specialty ,Subcutaneous calcification ,Radiography ,Bone Neoplasms ,Physical examination ,Fingers ,Heart Neoplasms ,Neoplasms, Multiple Primary ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,medicine ,Humans ,Blood test ,medicine.diagnostic_test ,business.industry ,Cartilage ,Myxoma ,medicine.disease ,medicine.anatomical_structure ,Subcutaneous nodule ,Radiology ,Left Atrial Myxoma ,Cardiology and Cardiovascular Medicine ,business - Abstract
A 32-year-old Japanese man presented to our hospital with a 5-month history of painful nodules on the fingers. He had previously developed left atrial myxoma followed by cerebral embolism and had undergone resection of the cardiac tumor 4 months before his first visit. His family history was unremarkable. Physical examination showed subcutaneous nodules 4 to 17 mm in size on all finger pads (Figure 1A and 1B). The tumors were smooth and as hard as cartilage. Hand radiographs showed irregularly shaped subcutaneous calcification corresponding to the nodules (Figure 2), and postoperative examination of the 3-dimensional computed tomographic reconstruction indicated the tumors more clearly (Figure 3). Physical examination and diagnostic imaging detected no tumors in other sites, including the lower extremities. The blood test results, including endocrine examination, were unremarkable. Figure 1. Subcutaneous nodules on all finger pads: the left …
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- 2016
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15. Recalcitrant granuloma faciale with 14-year follow-up
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Satoko Shimizu, Yohei Hamade, Kikuo Tsuchiya, Toshinari Miyauchi, Kazuhiro Kikuchi, Yusuke Morita, Keiko Shiba, and Reine Moriuchi
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medicine.medical_specialty ,business.industry ,lcsh:Dermatology ,medicine ,Granuloma faciale ,lcsh:RL1-803 ,GF ,PSL ,medicine.disease ,business ,Dermatology - Abstract
Granuloma faciale (GF) is an uncommon inflammatory dermatosis that is characterized by one or several asymptomatic brown red nodules or plaques usually occurring on the face. GF is known to be extremely resistant to treatment. Various treatments have been attempted, including topical or intralesional or systemic corticosteroids, dapsone, antimalarials, colchicine, topical tacrolimus, and topical psoralen; however, none of these have been found to be reliably efficacious. We tried numerous combinations and rotations of therapeutic modalities for GF over a long time. We described a case of GF in which the eruptions were carefully observed over the course of 14 years before finally resolving. Our experience suggests that continuous and careful follow-up, and trials of combinations and rotations of therapeutic modalities are essential for treating GF.
- Published
- 2017
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16. Effect of type of aromatic nucleus in lignin on the rate of the β-O-4 bond cleavage during alkaline pulping process
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Yuji Matsumoto, Satoko Shimizu, and Tomoya Yokoyama
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Cleavage (embryo) ,Medicinal chemistry ,Biomaterials ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Nucleophilic substitution ,medicine ,Common property ,Lignin ,Organic chemistry ,A value ,Nucleus ,Bond cleavage ,Conjugate - Abstract
Several C6–C3 and C6–C2-type dimeric non-phenolic β-O-4 lignin model compounds, whose aromatic nuclei consisting of the carbon skeleton and β-O-4 linkage are named the A- and B-rings, respectively, were treated under alkaline pulping conditions to examine whether or not the substitution of methoxyl group on the B-ring or of guaiacyl for syringyl A-ring accelerates the β-O-4 cleavage as a further study of our previous reports. It was suggested that either first or second substitution of methoxyl group on the B-ring accelerates the β-O-4 cleavage in both C6–C3 and C6–C2 compounds although the former compounds are more sensitive to the substitution than the latter, suggesting that the lack of the γ-hydroxymethyl group makes model compound insensitive to the substitution. It was confirmed that the substitution of guaiacyl for syringyl A-ring accelerates the β-O-4 cleavage in both C6–C3 and C6–C2 compounds with the degrees similar to each other regardless of the type of the B-ring. It was clarified that the leaving ability of the leaving B-ring phenoxides in the β-O-4 cleavage does not correlate well with the pK a values of the conjugate acids of the phenoxides, which is not in accordance with the common property of a nucleophilic substitution reaction.
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- 2015
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17. The first fatal case of Corynebacterium ulcerans infection in Japan
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Nobuya Harayama, Midori Ogawa, Akihiko Yamamoto, Masaaki Iwaki, Kaoru Umeda, Masayuki Kamochi, Mitsumasa Saito, Satoko Shimizu, Toshiyuki Umata, Ken Otsuji, Hiroyuki Seki, Takeru Endo, and Kazumasa Fukuda
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0301 basic medicine ,Microbiology (medical) ,Diphtheria toxin ,fatal ,pseudomembrane ,Companion animal ,030106 microbiology ,Virulence ,Case Report ,asphyxia ,Case presentation ,dyspnea ,Biology ,Microbiology ,03 medical and health sciences ,Emerging pathogen ,Ribotyping ,Corynebacterium ulcerans ,Respiratory ,Pulsed-field gel electrophoresis ,ECMO - Abstract
Introduction. Corynebacterium ulcerans (C. ulcerans) is a zoonotic pathogen that occasionally causes diphtheria-like symptoms in humans. Cases of C. ulcerans infection have been increasing in recent years, and C. ulcerans has been recognized as an emerging pathogen. Case presentation. Here we report a case of asphyxia death due to pseudomembrane caused by diphtheria toxin (DT)-producing C. ulcerans. This is, to our knowledge, the first fatal case of C. ulcerans infection in Japan. A strain of C. ulcerans was obtained from the patient’s pet cat and was confirmed to be identical to the patient’s isolate by sequencing of the 16S rRNA gene and the DT gene, by pulsed-field gel electrophoresis (PFGE) and by ribotyping. In the same way, it was revealed that the isolate in this case belonged to the same molecular type as the C. ulcerans 0102 isolated from the first case in Japan in a distant prefecture 15 years earlier, in 2001. Conclusion. DT-producing C. ulcerans can be contracted from a companion animal and causes human death if the appropriate treatment is delayed. The finding indicates that this molecular type of virulent C. ulcerans is currently widespread in Japan.
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- 2017
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18. Multiple Nodules Arising within a Birthmark on the Scalp: A Quiz
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Kunihiro Kawashima, Eiichi Arai, Yuka Maya, Yasuyuki Fujita, Koichi Honma, Satoko Shimizu, Takuya Mizukami, and Takahiro Tsuji
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medicine.medical_specialty ,Hardware_MEMORYSTRUCTURES ,Scalp ,Skin Neoplasms ,business.industry ,ComputingMilieux_PERSONALCOMPUTING ,MEDLINE ,Dermatology ,General Medicine ,lcsh:RL1-803 ,medicine.disease ,InformationSystems_MODELSANDPRINCIPLES ,medicine.anatomical_structure ,ComputingMilieux_COMPUTERSANDEDUCATION ,lcsh:Dermatology ,Skin Abnormalities ,medicine ,Humans ,Birthmark ,business ,Pigmentation Disorders - Abstract
is missing (Quiz)
- Published
- 2020
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19. Synergistic contribution of hydrosulfide and carbonate anions to the β-O-4 bond cleavage of lignin model compounds in a green liquor pretreatment for enzymatic hydrolysis of lignocellulosic materials
- Author
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Feng Gu, Yuji Matsumoto, Pattaraporn Posoknistakul, Tomoya Yokoyama, Yongcan Jin, and Satoko Shimizu
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Biomaterials ,chemistry.chemical_classification ,chemistry.chemical_compound ,Hydrolysis ,Enzyme ,Kraft process ,chemistry ,Enzymatic hydrolysis ,Green liquor ,Carbonate ,Lignin ,Organic chemistry ,Bond cleavage - Abstract
To examine why green liquor (GL) pretreatment of lignocellulosic materials effectively facilitates enzymatic saccharification under conditions milder than those of a common alkaline cooking process, dimeric β-O-4 type lignin model compounds with and without free phenolic hydroxyl group were reacted in several alkaline solutions including a model solution of GL, which mainly contains Na2CO3 and Na2S. The β-O-4 bond of the phenolic model compound was cleaved with a sufficient rate in the model solution of GL. The β-O-4 bond cleavage of the non-phenolic model compound was more frequent in the model solution of GL than in other alkaline solutions. These results suggest that β-O-4 bonds present in lignocellulosic materials are effectively cleaved in a GL pretreatment. It was also suggested that HS− and CO3 2− synergistically contribute to the β-O-4 bond cleavage of the non-phenolic model compound under GL pretreatment conditions.
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- 2014
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20. O2-dependent large electron flow functioned as an electron sink, replacing the steady-state electron flux in photosynthesis in the cyanobacterium Synechocystis sp. PCC 6803, but not in the cyanobacterium Synechococcus sp. PCC 7942
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Amane Makino, Hiroshi Yamamoto, Chikahiro Miyake, Ryosuke Hayashi, Satoko Shimizu, Keiichiro Shaku, Katsumi Amako, Masahiro Tamoi, Seiji Akimoto, Ginga Shimakawa, and Toshio Sugimoto
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Chlorophyll ,Cyanobacteria ,Light ,Cell Respiration ,Mutant ,Quantum yield ,chemistry.chemical_element ,Photosynthesis ,Applied Microbiology and Biotechnology ,Biochemistry ,Oxygen ,Analytical Chemistry ,Microbiology ,Electron Transport ,Species Specificity ,Respiration ,Molecular Biology ,Synechococcus ,biology ,Organic Chemistry ,Synechocystis ,Photosystem II Protein Complex ,General Medicine ,biology.organism_classification ,chemistry ,Biophysics ,Photorespiration ,Oxidation-Reduction ,Bacteria ,Biotechnology - Abstract
To determine whether alternative electron flow (AEF) can replace the photosynthetic electron flow in cyanobacteria, we used an open O2-electrode system to monitor O2-exchange over a long period. In air-grown Synechocystis sp. PCC 6803 (S. 6803(WT)), the quantum yield of PSII, Y(II), held even after photosynthesis was suppressed by CO2 shortage. The S. 6803 mutant, deficient in flavodiiron (FLV) proteins 1 and 3, showed the same phenotype as S. 6803(WT). In contrast, Y(II) decreased in Synechococcus sp. PCC 7942 (S. 7942). These results suggest that AEF functioned as the Y(II) in S. 6803 and replaced the photosynthetic electron flux. In contrast, the activity of AEF in S. 7942 was lower. The affinity of AEF for O2 in S. 6803 did not correspond to those of FLVs in bacteria or terminal oxidases in respiration. AEF might be driven by photorespiration.
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- 2014
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21. CUP-SHAPED COTYLEDON1 transcription factor activates the expression of LSH4 and LSH3, two members of the ALOG gene family, in shoot organ boundary cells
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Ayano Kariya, Li Zhao, Satoko Shimizu, Keiko Hanano, Masao Tasaka, Mitsuhiro Aida, Minami Matsui, and Seiji Takeda
- Subjects
Regulation of gene expression ,fungi ,Morphogenesis ,food and beverages ,Cell Biology ,Plant Science ,Biology ,Meristem ,biology.organism_classification ,Cell biology ,Arabidopsis ,Botany ,Shoot ,Genetics ,Gene family ,Primordium ,Transcription factor - Abstract
The establishment of organ boundaries is a fundamental process for proper morphogenesis in multicellular organisms. In plants, the shoot meristem repetitively forms organ primordia from its periphery, and boundary cells are generated between them to separate their cellular fates. The genes CUP-SHAPED COTYLEDON1 (CUC1) and CUC2, which encode plant-specific NAC transcription factors, play central roles in establishment of the shoot organ boundaries in Arabidopsis thaliana. Here we show that CUC1 protein activates expression of LIGHT-DEPENDENT SHORT HYPOCOTYLS 4 (LSH4) and its homolog LSH3 in shoot organ boundary cells. Both genes encode nuclear proteins of the Arabidopsis LSH1 and Oryza G1 (ALOG) family, the members of which are widely conserved in land plants. Expression of LSH4 and LSH3 is detected in the boundary cells of various shoot organs, such as cotyledons, leaves and floral organs, and requires the activity of CUC1 and CUC2. Experiments using the glucocorticoid receptor system indicate that transcription of LSH4 and LSH3 is directly up-regulated by CUC1. Constitutive expression of LSH4 in the shoot apex causes inhibition of leaf growth in the vegetative phase, and formation of extra shoots or shoot organs within a flower in the reproductive phase. Together, our results indicate that CUC1 directly activates transcription of the nuclear factor genes LSH4 and LSH3, which may suppress organ differentiation in the boundary region.
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- 2011
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22. Temperature Dependence of Crystal Growth Rate for α and β Forms of Isotactic Polypropylene
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Annette Thierry, Kayo Nakamura, Satoko Shimizu, Susume Umemoto, Norimasa Okui, and Bernard Lotz
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Polymers and Plastics ,Stereochemistry ,Chemistry ,Kinetics ,Nucleation ,Analytical chemistry ,Crystal growth ,law.invention ,Polymorphism (materials science) ,Electron diffraction ,law ,Tacticity ,Materials Chemistry ,Growth rate ,Crystallization - Abstract
The crystal growth rate of the α1, α2 and β forms of isotactic polypropylene (iPP) and their morphological changes were studied in a wide range of crystallization temperatures. The temperature dependence of the crystal growth rate of the α1 form showed a bell-shaped curve with the maximum growth rate (Gmax) at 70 °C. The crystal growth rate of the β form induced by calcium pimelate also showed a bell-shaped curve with Gmax at 79 °C. Two crossover points on the growth rate curve from the α1 form to the β form or vice versa were observed at 90 °C and 133 °C, respectively. Tear-drop shaped spherulites were observed at temperatures between the two crossover points. Electron diffraction patterns showed the high ordered structure of the α2 form for thin films crystallized at 140 °C. The α2 fraction became detectable in X-ray diffraction pattern for temperatures above 110 °C. The α2 fraction increased with crystallization temperature and saturated to 100% at about 140 °C. In the temperature region from 110 °C to 140 °C, several crystal growth rates were found at the same crystallization temperature. The growth rate variations could be associated with the co-crystallization of the α1 and α2 forms. Above 140 °C, the growth rate variations disappeared, since the fraction of the α2 reached to 100%. The extrapolated Gmax of the α2 showed at 72 °C.
- Published
- 2008
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23. A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10
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Nobuo Fuse, Satoko Shimizu, Maya Eibschitz-Tsimhoni, Julia E. Richards, David M. Reed, Alan Sugar, Edward H. Trager, Frank W. Rozsa, Michael Boehnke, Sayoko E. Moroi, Miriam T. Schteingart, Charles M. Krafchak, Catherine A. Downs, and Michael P. Epstein
- Subjects
Adult ,Genetic Markers ,Male ,Proband ,Quantitative Trait Loci ,Locus (genetics) ,Biology ,Quantitative trait locus ,Article ,Gene mapping ,Humans ,Genetics (clinical) ,Aged ,Corneal Dystrophies, Hereditary ,Genetics ,Chromosomes, Human, Pair 10 ,Genetic heterogeneity ,Haplotype ,Chromosome Mapping ,Middle Aged ,Pedigree ,Posterior polymorphous corneal dystrophy ,Phenotype ,Haplotypes ,Genetic marker ,Female - Abstract
Posterior polymorphous corneal dystrophy (PPCD) is an autosomal dominant disorder characterized by corneal endothelial abnormalities, which can lead to blindness due to loss of corneal transparency and sometimes glaucoma. We mapped a new locus responsible for PPCD in a family in which we excluded the previously reported PPCD locus on 20q11, and the region containing COL8A2 on chromosome 1. Results of a 317-marker genome scan provided significant evidence of linkage of PPCD to markers on chromosome 10, with single-point LOD scores of 2.63, 1.63, and 3.19 for markers D10S208 (at (circumflex)theta = 0.03), D10S1780 (at (circumflex)theta = 0.00), and D10S578 (at (circumflex)theta = 0.06). A maximum multi-point LOD score of 4.35 was found at marker D10S1780. Affected family members shared a haplotype in an 8.55 cM critical interval that was bounded by markers D10S213 and D10S578. Our finding of another PPCD locus, PPCD3, on chromosome 10 indicates that PPCD is genetically heterogeneous. Guttae, a common corneal finding sometimes observed along with PPCD, were found among both affected and unaffected members of the proband's sib ship, but were absent in the younger generations of the family. Evaluation of phenotypic differences between family members sharing the same affected haplotype raises questions about whether differences in disease severity, including differences in response to surgical interventions, could be due to genetic background or other factors independent of the PPCD3 locus.
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- 2004
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24. Cutaneous Manifestations of Helicobacter cinaedi Infection
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Satoshi Yamamoto, Satoko Shimizu, Toshiya Sakai, Daisuke Inokuma, Hiroshi Shimizu, Mika Watanabe, and Kikuo Tsuchiya
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Male ,medicine.medical_specialty ,Erythema ,Dermatology ,Helicobacter Infections ,Helicobacter cinaedi ,Superficial cellulitis ,Helicobacter ,Erythematous plaque ,medicine ,Humans ,General hospital ,Aged ,Skin ,Cross Infection ,biology ,business.industry ,Cellulitis ,General Medicine ,Middle Aged ,medicine.disease ,biology.organism_classification ,Anti-Bacterial Agents ,Treatment Outcome ,Female ,medicine.symptom ,business ,Skin lesion ,Sudden onset - Abstract
Helicobacter cinaedi causes gastroenteritis and bacter-aemia, particularly in immunocompromised individuals. Although cellulitis is sometimes reported to accompany infection by this pathogen, the cutaneous manifestations are poorly understood. To clarify the characteristic cutaneous features, 47 cases of H. cinaedi bacteraemia experienced at Sapporo City General Hospital as nosocomial infection were retrospectively evaluated. Thirty-four percent (16 cases) of the patients showed cutaneous lesions. They all had sudden onset of erythemas accompanied by high temperature. The most common cutaneous manifestations were found to be superficial cellulitis, which results in painful erythemas or infiltrated erythematous plaques on the extremities. These skin lesions can be an early clinical indicator of H. cinaedi bacteraemia in the setting of nosocomial infection.
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- 2013
- Full Text
- View/download PDF
25. Cutaneous manifestations of methotrexate-associated lymphoproliferative disorders: report of two cases and a review of the literature
- Author
-
Takamasa Ito, Masaya Mukai, Yuichiro Fukasawa, Kazuhiro Kikuchi, Junko Murata, Satoko Shimizu, Daisuke Inokuma, and Reine Moriuchi
- Subjects
Male ,medicine.medical_specialty ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,Skin Neoplasms ,Biopsy ,MEDLINE ,Lymphoproliferative disorders ,Dermatology ,In situ hybridization ,Immunocompromised Host ,Predictive Value of Tests ,Risk Factors ,Biomarkers, Tumor ,Medicine ,Humans ,In Situ Hybridization ,Aged ,medicine.diagnostic_test ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Human genetics ,Lymphoma ,Methotrexate ,Predictive value of tests ,DNA, Viral ,Female ,Lymphoma, Large B-Cell, Diffuse ,business ,Immunosuppressive Agents ,medicine.drug - Published
- 2014
26. A Large Germline Deletion of theMEN1Gene in a Family with Multiple Endocrine Neoplasia Type 1
- Author
-
Satoko Shimizu, Hitoyasu Futami, Takao Obara, Mari Kishi, Toshihiko Tsukada, Ken Yamaguchi, Masako Kanbe, and Yukio Ito
- Subjects
Gene dosage ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,endocrine system ,Cancer Research ,endocrine system diseases ,Biology ,medicine.disease_cause ,Polymerase Chain Reaction ,Article ,Germline ,Germline mutation ,Proto-Oncogene Proteins ,medicine ,Humans ,Deletion mapping ,MEN1 ,Tumor suppressor gene ,Multiple endocrine neoplasia ,Germ-Line Mutation ,Genetics ,Mutation ,Autosomal dominant trait ,medicine.disease ,DNA testing ,Molecular biology ,Neoplasm Proteins ,Pedigree ,Oncology ,Multiple endocrine neoplasia type 1 ,Female ,Chromosome Deletion ,Gene Deletion - Abstract
Multiple endocrine neoplasia type 1 (MEN1) is a familial cancer syndrome inherited as an autosomal dominant trait. Various heterozygous germline mutations of the responsible gene, MEN1, have been identified within its exons in many, but not all, affected individuals. We here demonstrate, by DNA polymorphism analysis and gene dosage analysis with polymerase chain reaction (PCR), a large heterozygous germline MEN1 deletion in a kindred with MEN1, in whom no mutation could be detected in the PCR-amplified exons. The deletion spanned an at least 7 kb region containing the entire MEN1 gene. These findings indicate that a large germline deletion of the MEN1 gene, which escapes detection in PCR-based sequence analysis, should be considered as a potential cause of MEN1.
- Published
- 1998
- Full Text
- View/download PDF
27. Germline Mutations of theMEN1Gene in Japanese Kindred with Multiple Endocrine Neoplasia Type 1
- Author
-
Akira Aoki, Ken Yamaguchi, Masako Kanbe, Kawano S, Masahiro Kawanaka, Shozo Uchiyama, Hitoyasu Futami, Takao Obara, Satoko Shimizu, Hiroko Yasuda, Yukio Ito, Toru Kameya, Kotaro Ui, and Toshihiko Tsukada
- Subjects
Proband ,endocrine system ,congenital, hereditary, and neonatal diseases and abnormalities ,Cancer Research ,endocrine system diseases ,Biology ,medicine.disease_cause ,Polymerase Chain Reaction ,Germline ,Germline mutation ,medicine ,Humans ,MEN1 ,Familial cancer syndrome ,Multiple endocrine neoplasia ,Gene ,Germ-Line Mutation ,Family Health ,Genetics ,Mutation ,DNA, Neoplasm ,medicine.disease ,DNA testing ,Oncology ,Multiple endocrine neoplasia type 1 ,Cancer research ,Rapid Communication ,Founder effect - Abstract
Multiple endocrine neoplasia type 1 (MEN1) is an autosotnal dominant familial cancer syndrome. The responsible gene MEN1 has recently been isolated, and its germline mutations have been identified in affected individuals in the United States, Canada and Europe. We screened for MEN1 mutations by direct nucleotide sequencing of all protein‐coding regions, and identified five distinct germline mutations in five among six Japanese kindreds with familial MEN1 or familial hyperparathyroidism. The mutations were dispersed across the gene. These findings suggest that, because of the absence of an obvious founder effect, the entire MEN1 gene region should be examined for germline mutations in the probands of MEN1 and related syndromes in Japanese families.
- Published
- 1997
- Full Text
- View/download PDF
28. Autosomal dominant optic atrophy with OPA1 gene mutations accompanied by auditory neuropathy and other systemic complications in a Japanese cohort.
- Author
-
Akiko Maeda-Katahira, Natsuko Nakamura, Takaaki Hayashi, Satoshi Katagiri, Satoko Shimizu, Hisao Ohde, Tatsuo Matsunaga, Kimitaka Kaga, Tadashi Nakano, Shuhei Kameya, Tomokazu Matsuura, Kaoru Fujinami, Takeshi Iwata, and Kazushige Tsunoda
- Published
- 2019
29. Kindler syndrome with severe intestinal involvement: a 31-year follow-up
- Author
-
Satoko Shimizu, Daisuke Inokuma, Hideki Nakamura, Wataru Nishie, Satoshi Motoya, Hiroshi Shimizu, Kazuhiro Kikuchi, Kikuo Tsuchiya, and Hanako Koguchi-Yoshioka
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Biopsy ,DNA Mutational Analysis ,Dermatology ,Constriction, Pathologic ,Severity of Illness Index ,Kindler syndrome ,Blister ,Intestinal mucosa ,Ileum ,Severity of illness ,medicine ,Humans ,Genetic Predisposition to Disease ,Photosensitivity Disorders ,Intestinal Mucosa ,Skin pathology ,Periodontal Diseases ,Skin ,medicine.diagnostic_test ,business.industry ,Ileal Diseases ,Disease progression ,Infant, Newborn ,Membrane Proteins ,General Medicine ,medicine.disease ,Immunohistochemistry ,Neoplasm Proteins ,Phenotype ,Recien nacido ,Mutation ,Disease Progression ,Epidermolysis bullosa ,business ,Epidermolysis Bullosa ,Intestinal Obstruction - Published
- 2013
30. Quantitative Difference in the Rates of the β-O-4 Bond Cleavage between Lignin Model Compounds with and without γ-Hydroxymethyl Groups during the Alkaline Pulping Process
- Author
-
Pattaraporn Posoknistakul, Tomoya Yokoyama, Yuji Matsumoto, and Satoko Shimizu
- Subjects
Steric effects ,Environmental Engineering ,Ethanol ,Diastereomer ,Bioengineering ,Medicinal chemistry ,Hydrolysis ,chemistry.chemical_compound ,chemistry ,Lignin ,Organic chemistry ,Hydroxide ,Hydroxymethyl ,Waste Management and Disposal ,Bond cleavage - Abstract
To examine the effect of the presence of γ-hydroxymethyl groups on the rate of the β-O-4 bond cleavage during the alkaline pulping process, the rates of the β-O-4 bond cleavage of non-phenolic lignin model compounds without a γ-hydroxymethyl group, 2-(2-methoxyphenoxy)-1-(3,4-dimethoxyphenyl)ethanol (G’G) and 2-(2,6-dimethoxyphenoxy)-1-(3,4-dimethoxyphenyl)ethanol (G’S), were compared with those of analogous model compounds with a γ-hydroxymethyl group, 2-(2-methoxyphenoxy)-1-(3,4-dimethoxyphenyl)propane-1,3-diol (GG) and 2-(2,6-dimethoxyphenoxy)-1-(3,4-dimethoxyphenyl)propane-1,3-diol (GS), under alkaline pulping conditions. The disappearance of G’G or G’S was accompanied by the quantitative liberation of 2-methoxyphenol or 2,6-dimethoxyphenol, respectively, indicating that the disappearance resulted from the β-O-4 bond cleavage. The disappearance rate of G’G or G’S was in between those of the erythro and threo isomers of GG or GS, respectively. This result seems to be reasonably explained when the steric repulsions of the three staggered conformations are taken into consideration. The disappearance rate of G’G or G’S increased, but the increment became moderate with increasing hydroxide concentration.
- Published
- 2013
- Full Text
- View/download PDF
31. CUP-SHAPED COTYLEDON1 transcription factor activates the expression of LSH4 and LSH3, two members of the ALOG gene family, in shoot organ boundary cells
- Author
-
Seiji, Takeda, Keiko, Hanano, Ayano, Kariya, Satoko, Shimizu, Li, Zhao, Minami, Matsui, Masao, Tasaka, and Mitsuhiro, Aida
- Subjects
Transcriptional Activation ,Transcription, Genetic ,Arabidopsis Proteins ,Arabidopsis ,Gene Expression Regulation, Developmental ,Nuclear Proteins ,Germination ,Plants, Genetically Modified ,Up-Regulation ,Plant Leaves ,Gene Expression Regulation, Plant ,Morphogenesis ,Inflorescence ,Plant Shoots ,Cell Proliferation - Abstract
The establishment of organ boundaries is a fundamental process for proper morphogenesis in multicellular organisms. In plants, the shoot meristem repetitively forms organ primordia from its periphery, and boundary cells are generated between them to separate their cellular fates. The genes CUP-SHAPED COTYLEDON1 (CUC1) and CUC2, which encode plant-specific NAC transcription factors, play central roles in establishment of the shoot organ boundaries in Arabidopsis thaliana. Here we show that CUC1 protein activates expression of LIGHT-DEPENDENT SHORT HYPOCOTYLS 4 (LSH4) and its homolog LSH3 in shoot organ boundary cells. Both genes encode nuclear proteins of the Arabidopsis LSH1 and Oryza G1 (ALOG) family, the members of which are widely conserved in land plants. Expression of LSH4 and LSH3 is detected in the boundary cells of various shoot organs, such as cotyledons, leaves and floral organs, and requires the activity of CUC1 and CUC2. Experiments using the glucocorticoid receptor system indicate that transcription of LSH4 and LSH3 is directly up-regulated by CUC1. Constitutive expression of LSH4 in the shoot apex causes inhibition of leaf growth in the vegetative phase, and formation of extra shoots or shoot organs within a flower in the reproductive phase. Together, our results indicate that CUC1 directly activates transcription of the nuclear factor genes LSH4 and LSH3, which may suppress organ differentiation in the boundary region.
- Published
- 2011
32. Localized linear IgA/IgG bullous dermatosis
- Author
-
Hiroshi Shimizu, Chikako Yasui, Satoko Shimizu, Ken Natsuga, Satoru Shinkuma, and Kikuo Tsuchiya
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Linear IgA bullous dermatosis ,Biopsy ,Prednisolone ,Immunoblotting ,Administration, Oral ,Anal Canal ,Human skin ,Dermatology ,Autoantigens ,Blister ,Skin Ulcer ,Medicine ,Humans ,Fluorescent Antibody Technique, Indirect ,Direct fluorescent antibody ,Glucocorticoids ,Dermoepidermal junction ,Aged ,Autoantibodies ,Skin ,Autoimmune disease ,integumentary system ,medicine.diagnostic_test ,Skin Diseases, Vesiculobullous ,business.industry ,Autoantibody ,General Medicine ,Non-Fibrillar Collagens ,medicine.disease ,Immunoglobulin A ,Treatment Outcome ,Fluorescent Antibody Technique, Direct ,Immunoglobulin G ,Skin biopsy ,business ,Dapsone - Abstract
Linear IgA/IgG bullous dermatosis (LAGBD) is an auto-immune blistering disease characterized by the local accumulation of IgA- and IgG-class anti-basement membrane autoantibodies. It typically presents as a generalized pruritic vesiculobullous eruption. No cases of localized LAGBD have yet been reported. We report a case of a 78-year-old man with LAGBD localized to the perianal area. The patient complained of suffering from persistent ulcers around the anus for more than 3 years. Physical examination revealed several blisters and ulcers up to 2-cm in diameter around the anus. No lesions were found elsewhere on the body. Histological analysis of a skin biopsy revealed subepidermal blistering, while direct immunofluorescence showed the linear deposition of IgA and IgG antibodies at the dermoepidermal junction. Indirect immunofluorescence of normal human skin whose layers had been separated using 1M NaCl showed the binding of both IgA and IgG to the epidermal side. Immunoblotting demonstrated the presence of circulating IgA and IgG autoantibodies that bound to a 120-kDa protein. This is the first case of localized LAGBD whose skin lesions were restricted to the perianal region.
- Published
- 2010
33. Contents Vol. 201, 2000
- Author
-
Isao Hashimoto, K. Kobayashi, Claire Pabion, Emin Ozbek, Brigitte Balme, J.R. Bogner, A. Stoehr, Fatih M. Uckun, A. Yamakage, Michelle Mertz, Ulrike Leiter, David Barzilay, R. Schianchi, T. Lorenzen, Ko-Ron Chen, Ryoji Tanei, Katsuto Tamai, Jivko Kamarashev, Henrik Hjalgrim, Piergiorgio Catalanotti, C. Monteagudo, Rama Malaviya, Sergei A. Grando, Alfredo De Rosa, Martina Kerscher, K. Kuroda, Hideji Hanabusa, A. Plettenberg, Itsuro Matsuo, A. Hatamochi, G. Martínez, A.J. Kanwar, M. David, Ersoy Hazneci, V. Navarro, Sarah Brenner, H. Nagayama, E. Phenig, Hiroko Gomi, D. Sahar, Ritsuko Konta, P. Altmeyer, Mustafa Cekmen, Edith Orion, Ravi Malaviya, Anne-Marie Viallard, Cem Evereklioglu, Brunello Wüthrich, E. Jordá, M. García, G. Bezold, Hideki Yokono, Tadashi Motoori, L. Maron, H. Rasokat, Lars Munksgaard, H. Shinkai, R.M. Ortega del Olmo, S. Serrano-Ortega, M. Feinmesser, K.H. Holubar, C. Prins, Akira Kawada, Luc Thomas, A. Buendia-Eisman, J. Linares Solano, Reinhard Dummer, G. Buchheim, H. Schöfer, Bruno Colecchia, Giovanna Donnarumma, Goro Sasaki, T. Gambichler, Hatsuki Shiraishi, François Skowron, S. Ishikiriyama, R. Bergman, A. Kuten, Adone Baroni, Francesco Figliola, K. Kaspar, G.P. Thami, S. Veraldi, Mads Melbye, Stefania Fracchiolla, Günter Burg, K. Hoffmann, Vito Ingordo, Pelin Ekmekçi, P. Lorenz, H. Albrecht, A.I. Bernal, Tarık Yazar, B. Amichai, Sukhjot Kaur, C. Carrera, Giuliano D’Andria, Masaaki Takahashi, T. Mertenskötter, M. Kobayashi, E. Hodak, A. González, Petra Gottlöber, Muhittin Yürekli, A.-A. Ramelet, Michael O. Kurrer, Monika Hess Schmidt, L. Naldi, Hisamichi Tagami, Masaki Okano, James Quinn, Roberto De Rosa, I. Pinazo, M. Imfeld, Toshiyuki Ohtsuka, Gertraud Krähn, Morten Frisch, Cosetta Minelli, H. Okita, Hamdi Er, Atsuko Kashima, B.T. Burtsche, Paul Scheidegger, T. Kaliebe, Kazuto Yasuda, Satoko Shimizu, H. Serhat Inaloz, E. Martínez, Hideo Orimo, Seiji Sato, C. Tschanz, Ralf-Uwe Peter, Luigi Naldi, Ayşe Boyvat, Martin Grob, Erbak Gürgey, Kensei Katsuoka, H. Aragoneses, Werner Kempf, S. Yamazaki, Anne-Sophie Causeret, and Laurie Lowe
- Subjects
Dermatology - Published
- 2000
- Full Text
- View/download PDF
34. Exacerbation of Pemphigus Foliaceus After Electron-beam Radiation
- Author
-
Daisuke Inokuma, Kazuhiro Kikuchi, Hanako Koguchi-Yoshioka, Chikako Yasui, Satoko Shimizu, and Reine Moriuchi
- Subjects
medicine.medical_specialty ,Skin Neoplasms ,Time Factors ,Exacerbation ,Dermatology ,Administration, Cutaneous ,Ointments ,Adrenal Cortex Hormones ,Recurrence ,medicine ,Humans ,Radiation Injuries ,Pemphigus foliaceus ,Radiotherapy ,Vulvar Neoplasms ,business.industry ,Remission Induction ,General Medicine ,Middle Aged ,medicine.disease ,Paget Disease, Extramammary ,Treatment Outcome ,Disease Progression ,Female ,Electron beam radiation ,business ,Pemphigus - Published
- 2014
- Full Text
- View/download PDF
35. Behçet’s Disease-like Symptoms Associated with Myelodysplastic Syndrome with Trisomy 8: A Case Report and Review of the Literature
- Author
-
Hanako Koguchi-Yoshioka, Daisuke Inokuma, Satoko Shimizu, Masatoshi Kanda, Makoto Kondo, and Kazuhiro Kikuchi
- Subjects
Male ,medicine.medical_specialty ,Fever ,Treatment outcome ,MEDLINE ,Trisomy ,Dermatology ,Behcet's disease ,Trisomy 8 ,Skin Ulcer ,medicine ,Humans ,Glucocorticoids ,Stomatitis ,business.industry ,Behcet Syndrome ,General Medicine ,Middle Aged ,medicine.disease ,Intestinal Diseases ,Treatment Outcome ,Myelodysplastic Syndromes ,Stomatitis, Aphthous ,Genital Diseases, Male ,business ,Chromosomes, Human, Pair 8 - Published
- 2014
- Full Text
- View/download PDF
36. A rare case of metastatic skin tumors originating from the sarcomatous component of lung carcinosarcoma.
- Author
-
Yuka Takashima, Reine Moriuchi, Takahisa Shirato, and Satoko Shimizu
- Subjects
SKIN tumors ,LUNGS ,GALLBLADDER - Abstract
The article present a case study of an 80‑year‑old Japanese man with hard nodules on the second to fourth fingers of the right hand. Topics include physical examination revealed hard skin coloured to reddish nodules on the right hand and the left side of the forehead; mentions a skin biopsy specimen from the digit showed dermal nodular proliferation of atypical chondrocyte‑like cells; and also mentions the lung tumor specimen showed a biphasic pattern consisting of atypical squamoid cells.
- Published
- 2019
- Full Text
- View/download PDF
37. Pancreatic panniculitis
- Author
-
Takamasa, Ito, Reine, Moriuchi, Kazuhiro, Kikuchi, and Satoko, Shimizu
- Subjects
Aged, 80 and over ,Pancreatic Neoplasms ,Panniculitis ,Paraneoplastic Syndromes ,Carcinoma ,Humans ,Female ,General Medicine ,Article - Published
- 2015
- Full Text
- View/download PDF
38. Synchronous Multiple Ossifying Tumors of the Digits: Metastatic Cardiac Myxoma.
- Author
-
Yohei Hamade, Reine Moriuchi, Toshinari Miyauchi, Kazuhiko Hirachi, Mitsuru Yanai, Yuichiro Fukazawa, Nobuki Miyamoto, Takaya Fukumoto, Takashi Anan, Satoko Shimizu, Hamade, Yohei, Moriuchi, Reine, Miyauchi, Toshinari, Hirachi, Kazuhiko, Yanai, Mitsuru, Fukazawa, Yuichiro, Miyamoto, Nobuki, Fukumoto, Takaya, Anan, Takashi, and Shimizu, Satoko
- Published
- 2016
- Full Text
- View/download PDF
39. Subject Index Vol. 201, 2000
- Author
-
H. Okita, Francesco Figliola, Ravi Malaviya, Martina Kerscher, Brigitte Balme, J.R. Bogner, Katsuto Tamai, James Quinn, Roberto De Rosa, M. Kobayashi, Isao Hashimoto, Sergei A. Grando, Hiroko Gomi, Gertraud Krähn, Ayşe Boyvat, Martin Grob, Kensei Katsuoka, A. Stoehr, Ralf-Uwe Peter, A.J. Kanwar, K. Hoffmann, Erbak Gürgey, Ritsuko Konta, Masaaki Takahashi, P. Altmeyer, Kazuto Yasuda, R. Schianchi, Satoko Shimizu, Luigi Naldi, C. Monteagudo, Muhittin Yürekli, M. García, D. Sahar, Giuliano D’Andria, Alfredo De Rosa, Giovanna Donnarumma, Sarah Brenner, Edith Orion, K. Kaspar, Claire Pabion, Emin Ozbek, A.-A. Ramelet, Henrik Hjalgrim, K. Kuroda, A. Plettenberg, Ulrike Leiter, I. Pinazo, M. Imfeld, Hideo Orimo, Reinhard Dummer, Toshiyuki Ohtsuka, E. Phenig, S. Yamazaki, R. Bergman, A. Kuten, K. Kobayashi, Anne-Sophie Causeret, G. Bezold, A. Buendia-Eisman, E. Martínez, G. Martínez, S. Ishikiriyama, H. Nagayama, G. Buchheim, Morten Frisch, Günter Burg, B.T. Burtsche, T. Mertenskötter, Mustafa Cekmen, Jivko Kamarashev, Cosetta Minelli, Paul Scheidegger, Stefania Fracchiolla, H. Schöfer, Piergiorgio Catalanotti, Ersoy Hazneci, David Barzilay, Hideji Hanabusa, H. Aragoneses, Tadashi Motoori, T. Kaliebe, Mads Melbye, Werner Kempf, Monika Hess Schmidt, L. Naldi, Fatih M. Uckun, Hatsuki Shiraishi, H. Albrecht, H. Rasokat, A. Yamakage, Hamdi Er, Ryoji Tanei, H. Serhat Inaloz, A. González, Rama Malaviya, V. Navarro, E. Hodak, Cem Evereklioglu, Petra Gottlöber, Itsuro Matsuo, A. Hatamochi, Luc Thomas, S. Serrano-Ortega, C. Tschanz, Ko-Ron Chen, K.H. Holubar, T. Lorenzen, C. Prins, M. Feinmesser, A.I. Bernal, Tarık Yazar, J. Linares Solano, Anne-Marie Viallard, Brunello Wüthrich, S. Veraldi, T. Gambichler, E. Jordá, H. Shinkai, François Skowron, M. David, Laurie Lowe, Seiji Sato, R.M. Ortega del Olmo, L. Maron, Hisamichi Tagami, Lars Munksgaard, Sukhjot Kaur, Masaki Okano, Akira Kawada, Atsuko Kashima, C. Carrera, Bruno Colecchia, Michael O. Kurrer, Goro Sasaki, Adone Baroni, G.P. Thami, Vito Ingordo, Pelin Ekmekçi, P. Lorenz, B. Amichai, Michelle Mertz, and Hideki Yokono
- Subjects
Index (economics) ,Statistics ,Subject (documents) ,Dermatology ,Mathematics - Published
- 2000
- Full Text
- View/download PDF
40. Acknowledgment to Referees for Dermatology
- Author
-
Itsuro Matsuo, A. Hatamochi, Michael O. Kurrer, T. Lorenzen, Anne-Marie Viallard, Brunello Wüthrich, Muhittin Yürekli, Michelle Mertz, Seiji Sato, Isao Hashimoto, Ravi Malaviya, A. Stoehr, B.T. Burtsche, Toshiyuki Ohtsuka, H. Nagayama, Giuliano D’Andria, H. Serhat Inaloz, M. David, Martina Kerscher, Sarah Brenner, Akira Kawada, Ritsuko Konta, J.R. Bogner, P. Altmeyer, S. Veraldi, Alfredo De Rosa, Atsuko Kashima, G. Buchheim, Bruno Colecchia, H. Okita, Hisamichi Tagami, Mustafa Cekmen, H. Schöfer, V. Navarro, I. Pinazo, Ayşe Boyvat, Martin Grob, Hideki Yokono, M. Imfeld, Fatih M. Uckun, Katsuto Tamai, Ralf-Uwe Peter, Sergei A. Grando, Goro Sasaki, David Barzilay, Kensei Katsuoka, A.J. Kanwar, Morten Frisch, Luc Thomas, Mads Melbye, J. Linares Solano, Luigi Naldi, Günter Burg, Masaki Okano, Rama Malaviya, Tadashi Motoori, H. Rasokat, Cosetta Minelli, Adone Baroni, D. Sahar, S. Serrano-Ortega, Giovanna Donnarumma, M. García, K.H. Holubar, K. Hoffmann, Vito Ingordo, Henrik Hjalgrim, E. Hodak, C. Tschanz, R. Bergman, A. Kuten, C. Carrera, Masaaki Takahashi, E. Jordá, H. Shinkai, C. Prins, G. Bezold, Petra Gottlöber, K. Kuroda, Reinhard Dummer, Francesco Figliola, Claire Pabion, Emin Ozbek, S. Ishikiriyama, Hideo Orimo, A. Plettenberg, A.-A. Ramelet, Hamdi Er, Ulrike Leiter, E. Martínez, E. Phenig, Erbak Gürgey, A. Buendia-Eisman, Ersoy Hazneci, Edith Orion, K. Kaspar, T. Mertenskötter, R. Schianchi, S. Yamazaki, Anne-Sophie Causeret, A. Yamakage, L. Maron, R.M. Ortega del Olmo, Kazuto Yasuda, Monika Hess Schmidt, L. Naldi, Cem Evereklioglu, Piergiorgio Catalanotti, Lars Munksgaard, Sukhjot Kaur, T. Gambichler, K. Kobayashi, Ko-Ron Chen, François Skowron, M. Feinmesser, G.P. Thami, Laurie Lowe, Brigitte Balme, Satoko Shimizu, Pelin Ekmekçi, Paul Scheidegger, H. Albrecht, Stefania Fracchiolla, C. Monteagudo, P. Lorenz, B. Amichai, T. Kaliebe, A. González, A.I. Bernal, Tarık Yazar, Jivko Kamarashev, G. Martínez, James Quinn, Roberto De Rosa, H. Aragoneses, Werner Kempf, Gertraud Krähn, Ryoji Tanei, Hideji Hanabusa, M. Kobayashi, Hatsuki Shiraishi, and Hiroko Gomi
- Subjects
medicine.medical_specialty ,business.industry ,Medicine ,Dermatology ,business - Published
- 2000
- Full Text
- View/download PDF
41. Localized Linear IgA/IgG Bullous Dermatosis.
- Author
-
Satoko Shimizu, Natsuga, Ken, Shinkuma, Satoru, Yasui, Chikako, Tsuchiya, Kikuo, and Shimizu, Hiroshi
- Subjects
- *
AUTOIMMUNE diseases , *IMMUNOGLOBULIN A , *IMMUNOGLOBULIN G , *AUTOANTIBODIES , *ANAL diseases - Abstract
Linear IgA/IgG bullous dermatosis (LAGBD) is an autoimmune blistering disease characterized by the local accumulation of IgA- and IgG-class anti-basement membrane autoantibodies. It typically presents as a generalized pruritic vesiculobullous eruption. No cases of localized LAGBD have yet been reported. We report a case of a 78-year-old man with LAGBD localized to the perianal area. The patient complained of suffering from persistent ulcers around the anus for more than 3 years. Physical examination revealed several blisters and ulcers up to 2-cm in diameter around the anus. No lesions were found elsewhere on the body. Histological analysis of a skin biopsy revealed subepidermal blistering, while direct immunofluorescence showed the linear deposition of IgA and IgG antibodies at the dermoepidermal junction. Indirect immunofluorescence of normal human skin whose layers had been separated using 1M NaCl showed the binding of both IgA and IgG to the epidermal side. Immunoblotting demonstrated the presence of circulating IgA and IgG autoantibodies that bound to a 120-kDa protein. This is the first case of localized LAGBD whose skin lesions were restricted to the perianal region. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
42. Cutaneous Manifestations of Methotrexate-associated Lymphoproliferative Disorders: Report of Two Cases and a Review of the Literature.
- Author
-
Satoko Shimizu, Daisuke Inokuma, Junko Murata, Kazuhiro Kikuchi, Takamasa Ito, Yuichiro Fukasawa, Masaya Mukai, and Moriuchi, Reine
- Abstract
The article describes cases of older patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD). Topics cited include the cutaneous manifestations of MTX-LPD, association of MTX with Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma, spontaneous regression of lymphoma after MTX discontinuation, and expression of EBV in tumor cells.
- Published
- 2015
- Full Text
- View/download PDF
43. Exacerbation of Pemphigus Foliaceus After Electron-beam Radiation.
- Author
-
Kazuhiro Kikuchi, Daisuke Inokuma, Reine Moriuchi, Hanako Koguchi-Yoshioka, Chikako Yasui, and Satoko Shimizu
- Subjects
RADIOTHERAPY ,OSTEITIS deformans ,BLISTERS - Abstract
A case study describing the exacerbation of pemphigus foliaceus after electron-beam radiation for extramammary Paget's disease is presented. Topics discussed include the clinical history of the patient, how the diagnosis of pemphigus foliaceus was made, and the necessity of precautions against the exacerbation of pemphigus after irradiation. The need to be aware of the occurrence of pemphigus after irradiation even in cases with no history of blistering diseases is noted.
- Published
- 2014
- Full Text
- View/download PDF
44. Kindler Syndrome with Severe Intestinal Involvement: A 31-year Follow-up.
- Author
-
Satoko Shimizu, Wataru Nishie, Kikuo Tsuchiya, Daisuke Inokuma, Hanako Koguchi-Yoshioka, Kazuhiro Kikuchi, Satoshi Motoya, Hideki Nakamura, and Hiroshi Shimizu
- Subjects
- *
DERMATOLOGY - Abstract
The article describes a case study concerning a 31-year-old male patient with Kindler syndrome (KS) accompanied by severe intestinal involvement. Topics discussed include multiple blisters and erosions presented by the patient at birth, mutations in the FERMT1 gene that cause KS, and cutaneous features. Also mentioned are intestinal involvement such as colitis and diarrhea in childhood, occurrence of severe late-onset ileal strictures, and genotype correlation.
- Published
- 2014
- Full Text
- View/download PDF
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