29 results on '"Satou, H."'
Search Results
2. Relationship between natriuretic peptide and pulmonary capillary wedge pressure estimated by three-dimensional speckle tracking echocardiography in patients with dialysis
- Author
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Satou, H., primary, Kawasaki, M., additional, Watanabe, T., additional, Kondo, K., additional, Nagata, K., additional, Sawada, S., additional, Noda, T., additional, Watanabe, S., additional, Minatoguchi, S., additional, and Goto, K., additional
- Published
- 2013
- Full Text
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3. Noninvasive estimation of left ventricular diastolic function using three-dimensional speckle tracking echocardiography in patients with hemodialysis
- Author
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Satou, H., primary, Kawasaki, M., additional, Watanabe, T., additional, Furuta, A., additional, Kariya, T., additional, Sawada, S., additional, Goto, K., additional, Noda, T., additional, Watanabe, S., additional, and Minatoguchi, S., additional
- Published
- 2013
- Full Text
- View/download PDF
4. Extracorporeal dialysis: techniques and adequacy - A
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Steckiph, D., primary, Calabrese, G., additional, Bertucci, A., additional, Mazzotta, A., additional, Vagelli, G., additional, Gonella, M., additional, Stamopoulos, D., additional, Manios, E., additional, Papachristos, N., additional, Grapsa, E., additional, Papageorgiou, G., additional, Gogola, V., additional, So, B., additional, Dey, V., additional, Spalding, E. M., additional, Libetta, C., additional, Esposito, P., additional, Margiotta, E., additional, Maffioli, P., additional, Bonaventura, A., additional, Bianchi, L., additional, Romano, D., additional, Rampino, T., additional, De Rosa, G., additional, Mauric, A., additional, Haug, U., additional, Enzinger, G., additional, Kern-Derstvenscheg, E., additional, Sluga, A., additional, Ausserwinkler, C., additional, Beck, W., additional, Rosenkranz, A. R., additional, Maheshwari, V., additional, Haroon, S., additional, Loy, Y., additional, Samavedham, L., additional, Rangaiah, G. P., additional, Lau, T., additional, Mpakirtzi, N., additional, Panagiotou, M., additional, Barbarousi, D., additional, Matsouka, C., additional, Bunani, A. D., additional, Kowalczyk, M., additional, Bartnicki, P., additional, Banach, M., additional, Rysz, J., additional, Lentini, P., additional, Zanoli, L., additional, Granata, A., additional, Contestabile, A., additional, Basso, A., additional, Berlingo, G., additional, Pellanda, V., additional, de Cal, M., additional, Grazia, V., additional, Clementi, A., additional, Insalaco, M., additional, Dell'Aquila, R., additional, Karkar, A., additional, Abdelrahman, M., additional, Martins, A. R., additional, Parreira, L., additional, Duque, A. S., additional, Rodrigues, I., additional, Baffoun, A. B., additional, Youssfi, M. A., additional, Sayeh, A., additional, Beji, M., additional, Ben Khadra, R., additional, Hmida, J., additional, Akazawa, M., additional, Horiuchi, H., additional, Hori, Y., additional, Yamada, A., additional, Satou, H., additional, Odamaki, S., additional, Nakai, S., additional, Satou, K., additional, Aoki, K., additional, Saito, I., additional, Kamijo, Y., additional, Ogata, S., additional, Ishibashi, Y., additional, Basso, F., additional, Wojewodzka-Zelezniakowicz, M., additional, Cruz, D., additional, Giuliani, A., additional, Blanca Martos, L., additional, Piccinni, P., additional, Ronco, C., additional, Potier, J., additional, Queffeulou, G., additional, Bouet, J., additional, Nilsson, A., additional, Sternby, J., additional, Grundstrom, G., additional, Alquist, M., additional, Ferraresi, M., additional, Di Vico, M. C., additional, Vigotti, F. N., additional, Deagostini, M., additional, Scognamiglio, S., additional, Consiglio, V., additional, Clari, R., additional, Moro, I., additional, Mongilardi, E., additional, Piccoli, G. B., additional, Hancock, V., additional, Huang, S., additional, Nilsson Ekdahl, K., additional, Steckiph, D., additional, Baldin, C., additional, Petrarulo, M., additional, Mancuso, D., additional, Inguaggiato, P., additional, Canepari, G., additional, Gigliola, G., additional, Ferrando, C., additional, Meinero, S., additional, Sicuso, C., additional, Pacitti, A., additional, Afentakis, N., additional, Tomo, T., additional, Matsuyama, K., additional, Nakata, T., additional, Ishida, K., additional, Takeno, T., additional, Kadota, J.-i., additional, Minakuchi, J., additional, Kastl, J., additional, Merello, M., additional, Boccato, C., additional, Giordana, G., additional, Mazzone, S., additional, Moscardo, V., additional, Reinhardt, B., additional, Knaup, R., additional, Kruger, W., additional, Tovbin, D., additional, Kim, S., additional, Avnon, L., additional, Zlotnik, M., additional, Storch, S., additional, Umimoto, K., additional, Shimamoto, Y., additional, Suyama, M., additional, Miyata, M., additional, Bosch Benitez-Parodi, E., additional, Baamonde Laborda, E. E., additional, Perez, G., additional, Ramirez, J. I., additional, Ramirez Puga, A., additional, Guerra, R., additional, Garcia Canton, C., additional, Lago Alonso, M. M., additional, Toledo, A., additional, Checa Andres, M. D., additional, Latif, F. E., additional, Mochida, Y., additional, Matsumoto, K., additional, Morita, K., additional, Tsutsumi, D., additional, Ishioka, K., additional, Maesato, K., additional, Oka, M., additional, Moriya, H., additional, Hidaka, S., additional, Ohtake, T., additional, Kobayashi, S., additional, Ficheux, A., additional, Gayrard, N., additional, Duranton, F., additional, Guzman, C., additional, Szwarc, I., additional, Bismuth-Mondolfo, J., additional, Brunet, P., additional, Servel, M.-F., additional, Argiles, A., additional, Tsikliras, N., additional, Mademtzoglou, S., additional, Balaskas, E., additional, Zeid, M., additional, Mostafa, A., additional, Mowafy, M. N., additional, Abdo, E. I., additional, Al Amin, O. M., additional, Ksiazek, A., additional, Zaluska, W., additional, Waniewski, J., additional, Debowska, M., additional, Wojcik-Zaluska, A., additional, Elias, M., additional, Francois, H., additional, Obada, E., additional, Lorenzo, H. K., additional, Charpentier, B., additional, Durrbach, A., additional, Beaudreuil, S., additional, Imamovic, G., additional, Marcelli, D., additional, Bayh, I., additional, Hrvacevic, R., additional, Kapun, S., additional, Grassmann, A., additional, Scatizzi, L., additional, Maslovaric, J., additional, Daelemans, R., additional, Mesens, S., additional, Mohamed, E. A., additional, Wafae, A., additional, Kawtar, H., additional, Mohamed Amine, H., additional, Driss, K., additional, and Mohammed, B., additional
- Published
- 2013
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5. New screen printable polyimide for IC devices
- Author
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Nishizawa, H., primary, Suzuki, K., additional, Kikuchi, T., additional, and Satou, H., additional
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- 1990
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6. Ion and Water Transport Characteristics of Perfluorosulfonated Ionomer Membranes with H<SUP>+</SUP> and Alkali Metal Cations
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Okada, T., Satou, H., Okuno, M., and Yuasa, M.
- Abstract
Ion and water transport characteristics of Nafion ionomer membranes were investigated systematically in the mixed cation form of H+ and various kinds of alkali metal cation systems, which were prepared by equilibrating the membranes in the mixtures of HCl and alkali chloride in aqueous solutions of various mixing ratios. The membrane cationic composition showed that cations of larger atomic number had a higher affinity to sulfonic acid groups but less water content in the membrane than those of smaller atomic numbers. The net ionic conductivity was decreased, in any case, by the presence of alkali metal cations in the membrane. Different kinds of the interaction mode among cations were observed between H/Li or H/Na systems and H/K, H/Rb, or H/Cs systems. The interaction between alkali metal cations appeared to increase as the atomic number of the alkali metal cation increased. The water transference coefficient (electro-osmosis drag coefficient) increased from 2.5 to more than 10 by the presence of alkali metal cations. In the mixed systems, these cations were found to cause less water molecule drag than in the case of individual ions, in the presence of H+ ion. Overall, the transport characteristics of H+ and alkali metal cations influenced each other by way of the water molecules when they coexist in the membrane.
- Published
- 2002
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7. The Effect of Impurity Cations on the Oxygen Reduction Kinetics at Platinum Electrodes Covered with Perfluorinated Ionomer
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Okada, T., Ayato, Y., Satou, H., Yuasa, M., and Sekine, I.
- Abstract
The mechanism of how impurity cations suppress the kinetics of oxygen reduction reaction on platinum surface covered with perfluoro-sulfonated ionomer film was studied in 0.1 N H
2 SO4 in the presence of various kinds of impurity ions of several concentrations. Impurity cations tested were Li+, Na+, K+, Ca2+, Fe3+, Ni2+, and Cu2+ with the amount of 0.1%, 1%, and 10% as compared with H+ in the solution. Platinum disk of a rotating disk electrode was spin-coated with Nafion solution, and after drying the Nafion film-covered platinum was obtained. The electrochemical measurements were performed to evaluate both charge transfer and diffusion kinetics of oxygen reduction at the Nafion film-covered electrode. It was discovered that the impurity ions hindered enormously the rate of charge-transfer step at platinum covered with perfluoro-sulfonated ionomer. The suppression started already at 0.1% level of impurity concentration, but did not increase much at over 1% level. No suppression effect for oxygen reduction was observed for a bare platinum in the solution containing impurity ions, indicating that the effect is specific to the metal electrode−ionomer membrane interface. Also both the diffusion coefficient of oxygen and oxygen concentration in the membrane decreased by the presence of impurity cations. It was implied that all the process is related to the reorientation of polymer networks in the membrane, which might bring about the modification of electric double layer at the platinum−ionomer interface.- Published
- 2001
8. A case of repeated Kounis syndrome after anaphylactic shock: A note for disease management.
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Kawaguchi S, Kuroshima T, Namba R, Satou H, Kashiwagi R, Abe A, and Okada M
- Abstract
Background: Kounis syndrome (KS) is an underdiagnosed disease. The management of the disease remains elusive because of its infrequency., Case Presentation: A 78-year-old man with anaphylactic shock was admitted to our hospital 2 h after multiple bee stings. After recovering from an anaphylactic reaction, he presented with chest pain with ST elevation. We diagnosed him with KS. After a continuous intravenous infusion of vasodilators, his chest pain and ST elevation improved. However, chest pain with ST-segment elevation recurred the next day. Coronary angiography revealed severe stenosis in the middle left anterior descending coronary artery, and drug-eluting stents were implanted. The patient was discharged on foot after treatment for heart failure., Conclusion: KS, in which anaphylaxis and acute coronary syndrome occur simultaneously, can recur repeatedly after an initial anaphylactic reaction; however, it could be delayed or it could present simultaneously with the anaphylactic reaction. Therefore, long-term observation is important., Competing Interests: None declared., (© 2024 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine.)
- Published
- 2024
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9. Clinical Study of a High Accuracy Green Design Blood Glucose Monitor Using an Innovative Optical Transmission Absorbance System.
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Moriuchi T, Otaki Y, Satou H, Chai F, Hayashida Y, Aikawa R, Sugiyama T, and Sode K
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- Blood Glucose, Blood Glucose Self-Monitoring, Data Collection, Humans, Diabetes Mellitus, Type 2, Hyperglycemia
- Abstract
Background: Blood glucose monitoring (BGM) is essential for glycemic control in diabetic therapy. Followingly, accurate sensors are required for both daily personal and clinical use. The frequency of sensor use in patients with diabetes facilitates the use of disposable components. However, BGM systems are not exempt from green innovation sustainability initiatives., Methods: Clinical study of a high-accuracy green design blood glucose monitor using an innovative optical transmission absorbance system was carried out. Venous blood samples were collected from 104 patients with type II diabetes. The heat resistance of sensor strips was evaluated by storing sensor strips at 25℃ and 60℃ for approximately 3 months. Accuracy of the BGM system was evaluated via the ISO 15197:2013 protocol., Results: The BGM system achieved ±7.1% accuracy in glycemic level measurement, with 84% of all measurements within ±5% of the reference values. Furthermore, the sensor strip demonstrated heat resistance for more than 3 months when stored at 60℃., Conclusions: A new, highly accurate BGM system was developed based on the latest optical measurement system, introducing a rare metal-free "green-strip." The developed BGM system achieved the highest reported accuracy in clinical research, using venous blood from patients with diabetes. The sensor strip also exhibited high heat resistance, reducing limitations on storage conditions.
- Published
- 2022
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10. A case of radiation-induced subclavian artery stenosis treated with percutaneous transluminal angioplasty.
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Yamanaka T, Fukatsu T, Satou H, Ichinohe Y, Komatsu H, and Hirata Y
- Abstract
We report on a female patient who underwent a standard radical mastectomy and radiation therapy for right breast cancer at the age of 50 years without recurrence. At the age of 76 years, she started to experience fatigue in the right upper limb. The symptom gradually worsened and she was admitted to our hospital for further investigation. With computed tomography scan and angiography, we observed a high degree of subclavian artery (SCA) stenosis and asymptomatic right common carotid artery (CCA) stenosis. After undergoing carotid artery stenting to the right CCA stenosis at another hospital, we performed percutaneous transluminal angioplasty to SCA. Although we chose to treat the highly calcified lesion only with a balloon and slightly decreased the degree of stenosis, her symptoms clearly improved. Since arterial severely stenotic lesions were limited in the area of radiation exposure while other part of the arteries looked smooth and relatively free of sclerosis, it was highly suspected that arterial injury was induced by radiation. There are few reports of radiation-induced injury of upper limbs. However, this case suggests that we need to consider the possibility of radiation-induced arterial injury in patients with a history of radiation therapy. < Learning objective: There are few reports regarding upper limb arterial stenosis and occlusion due to radiation-induced arterial injury. However, the underlying mechanism might be overlooked because the symptoms such as fatigue and numbness of the upper limb caused by arterial stenosis and occlusion resembled those of lymphedema and nerve disorders that frequently occur after mastectomy. This case suggests that we need to consider the possibility of radiation-induced arterial injury in the patients with a history of radiation therapy.>.
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- 2015
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11. Whole-body counter surveys of Miharu-town school children for four consecutive years after the Fukushima NPP accident.
- Author
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Hayano RS, Tsubokura M, Miyazaki M, Satou H, Sato K, Masaki S, and Sakuma Y
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- Adolescent, Body Burden, Cesium Radioisotopes analysis, Child, Drinking, Female, Humans, Japan, Male, Data Collection, Fukushima Nuclear Accident, Schools, Whole-Body Counting
- Abstract
Comprehensive whole-body counter surveys of Miharu-town school children have been conducted for four consecutive years, in 2011-2014. This represents the only long-term sampling-bias-free study of its type conducted after the Fukushima Dai-ichi accident. For the first time in 2014, a new device called the Babyscan, which has a low (134/137)Cs MDA of <50 Bq/body, was used to screen the children shorter than 130 cm. No child in this group was found to have detectable level of radiocesium. Using the MDAs, upper limits of daily intake of radiocesium were estimated for each child. For those screened with the Babyscan, the upper intake limits were found to be ≲1 Bq/day for (137)Cs. Analysis of a questionnaire filled out by the children's parents regarding their food and water consumption shows that the majority of Miharu children regularly consume local and/or home-grown rice and vegetables. This however does not increase the body burden.
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- 2015
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12. Comprehensive whole-body counter surveys of Miharu-town school children for three consecutive years after the Fukushima NPP accident.
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Hayano RS, Tsubokura M, Miyazaki M, Satou H, Sato K, Masaki S, and Sakuma Y
- Subjects
- Adolescent, Age Distribution, Child, Food Contamination, Radioactive statistics & numerical data, Humans, Schools, Students, Surveys and Questionnaires, Data Collection, Fukushima Nuclear Accident, Nuclear Power Plants, Whole-Body Counting
- Abstract
Comprehensive whole-body counter surveys covering over 93% of the school children between the ages of 6 and 15 in Miharu town, Fukushima Prefecture, have been conducted for three consecutive years, in 2011, 2012 and 2013. Although the results of a questionnaire indicate that approximately 60% of the children have been regularly eating local or home-grown rice, in 2012 and 2013 no child was found to exceed the (137)Cs detection limit of 300 Bq/body.
- Published
- 2014
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13. The impact of the 2011 Great East Japan Earthquake on hospitalisation for respiratory disease in a rapidly aging society: a retrospective descriptive and cross-sectional study at the disaster base hospital in Ishinomaki.
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Yamanda S, Hanagama M, Kobayashi S, Satou H, Tokuda S, Niu K, and Yanai M
- Abstract
Objective: To investigate the impact in an aging society of the 2011 Great East Japan earthquake on hospitalisation for respiratory disease at the disaster base hospital., Design: Descriptive and cross-sectional study., Setting: Emergency care in Japanese Red Cross Ishinomaki Hospital, a regional disaster base hospital in Miyagi, Japan., Participants: 322 emergency patients who were hospitalised for respiratory disease from 11 March to 9 May 2011, and 99 and 105 emergency patients who were hospitalised in the corresponding periods in 2009 and 2010, respectively., Main Outcome Measures: Description and comparison of patient characteristics and disease distribution in terms of age, time after the disaster and activities of daily living (ADL)., Results: 1769 patients were admitted to our hospital during the study period (compared to 850 in 2009 and 1030 in 2010), among whom 322 were hospitalised for respiratory disease (compared to 99 in 2009 and 105 in 2010). Pneumonia (n=190, 59.0%) was the most frequent cause of admission for pulmonary disease, followed by acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) (n=53, 16.5%), asthma attacks (n=27, 8.4%) and progression of lung cancer (n=22, 6.8%). Compared with the corresponding periods in 2009 and 2010, the increase in the absolute numbers of admissions was highest for pneumonia, followed by AE-COPD and asthma attacks. At hospitalisation, 195 patients were 'dependent' and 54 patients were 'partially dependent'. Respiratory admissions accompanied by deterioration of ADL after the disaster were more frequent in elderly and female patients., Conclusions: After the Great East Japan Earthquake, admissions for pneumonia and exacerbation of chronic respiratory disease in the elderly increased at the disaster base hospital.
- Published
- 2013
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14. Internal radiocesium contamination of adults and children in Fukushima 7 to 20 months after the Fukushima NPP accident as measured by extensive whole-body-counter surveys.
- Author
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Hayano RS, Tsubokura M, Miyazaki M, Satou H, Sato K, Masaki S, and Sakuma Y
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Cesium Radioisotopes analysis, Child, Environmental Exposure analysis, Hospitals statistics & numerical data, Humans, Middle Aged, Time Factors, Young Adult, Data Collection, Fukushima Nuclear Accident, Nuclear Power Plants, Radiation Monitoring, Whole-Body Counting
- Abstract
The Fukushima Dai-ichi NPP accident contaminated the soil of densely-populated regions in Fukushima Prefecture with radioactive cesium, which poses significant risks of internal and external exposure to the residents. If we apply the knowledge of post-Chernobyl accident studies, internal exposures in excess of a few mSv/y would be expected to be frequent in Fukushima.Extensive whole-body-counter surveys (n = 32,811) carried out at the Hirata Central Hospital between October, 2011 and November, 2012, however show that the internal exposure levels of residents are much lower than estimated. In particular, the first sampling-bias-free assessment of the internal exposure of children in the town of Miharu, Fukushima, shows that the (137)Cs body burdens of all children (n = 1,383, ages 6-15, covering 95% of children enrolled in town-operated schools) were below the detection limit of 300 Bq/body in the fall of 2012. These results are not conclusive for the prefecture as a whole, but are consistent with results obtained from other municipalities in the prefecture, and with prefectural data.
- Published
- 2013
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15. [Problem and assignment for distinguishing the Usher syndrome type].
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Iwasaki S, Yoshimura H, Takeichi N, Satou H, Ishikawa K, Kaga K, Kumakawa K, Nagai K, Furuya N, Ikezono T, Nakanishi H, Naitou Y, Fukushima K, Tono T, Kimitsuki T, Nishio S, Takumi Y, and Usami S
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- Adult, Aged, Aged, 80 and over, Diagnosis, Differential, Female, Genetic Testing methods, Humans, Male, Middle Aged, Mutation genetics, Retinitis Pigmentosa diagnosis, Retinitis Pigmentosa genetics, Retrospective Studies, Usher Syndromes genetics, Usher Syndromes diagnosis
- Abstract
Usher syndrome is an autosomal-recessive disorder that causes bilateral sensorineural hearing loss, retinitis pigmentosa (RP), and occasionally vestibular dysfunction. Usher syndrome types 1, 2, and 3 can be distinguished by differences in audiovestibular features. The objectives of this retrospective study were to evaluate 26 patients with Usher syndrome clinically. The 26 patients (male: 12 cases, female: 14 cases) with Usher syndrome, with a clinical diagnosis based on symptoms of bilateral sensorineural hearing loss and RP, had been registered from 13 hospitals as a multicenter study. We assessed the clinical history and performed audiovestibular and ophthalmologic examinations, and genetic testing. Eleven of the patients were classified as having Usher type 1 (38.5%), 6 with Usher type 2 (23.1%), and 9 with Usher type 3 (38.5%). However, many patients with atypical Usher type 1 (70%) and type 2 (83.3%) were found compared with Usher type 3 (10%). The conductive rate of vestibular examinations including the caloric test (50%) was low. There were many variations in the clinical symptoms in Usher syndrome patients, therefore the classification of Usher types 1, 2, and 3 has been complicated. We have proposed a flowchart for the diagnosis of Usher types 1, 2, and 3.
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- 2012
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16. Identifying prognostic factors in Japanese women with pseudomyxoma peritonei: a retrospective clinico-pathological study of the Tohoku Gynecologic Cancer Unit.
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Kojimahara T, Nakahara K, Shoji T, Sugiyama T, Takano T, Yaegashi N, Yokoyama Y, Mizunuma H, Tase R, Satou H, Tanaka T, Motoyama T, and Kurachi H
- Subjects
- Adult, Aged, Aged, 80 and over, Asian People, Female, Gynecology, Humans, Japan, Middle Aged, Oncology Service, Hospital, Peritoneal Neoplasms etiology, Peritoneal Neoplasms mortality, Peritoneal Neoplasms pathology, Prognosis, Pseudomyxoma Peritonei etiology, Pseudomyxoma Peritonei mortality, Pseudomyxoma Peritonei pathology, Retrospective Studies, Risk Factors, Survival Analysis, Peritoneal Neoplasms diagnosis, Pseudomyxoma Peritonei diagnosis
- Abstract
Pseudomyxoma peritonei (PMP) is a rare condition of mucinous ascites associated mainly with mucinous tumors of appendix or ovary. PMP often recurs after treatment and may eventually cause death by abdominal visceral dysfunction via compression with mucinous ascites. Although radical peritonectomy and hyperthermic intra-peritoneal chemotherapy are becoming popular globally, the optimal treatment of PMP has not been established in Japan. We conducted a retrospective multicenter study to clarify the optimal treatment and the prognostic factors of PMP. A total of 23 patients with PMP were analyzed in the Tohoku Gynecologic Cancer Unit (TGCU). Clinical and follow-up data were retrieved and a central pathology review was performed. The median follow-up period was 46 months. Eleven patients underwent complete resection. There were 7 deaths out of 13 recurrences/progressions in this period. All the recurrence/progression was confined to the abdomen. Unexpectedly, neither radical peritonectomy nor hyperthermic intra-peritoneal chemotherapy had been performed, indicating that both radical peritonectomy and hyperthermic intra-peritoneal chemotherapy are not yet popular in Japan. The medians of overall survival and disease-free period were 166 months and 30 months, respectively. Univariate and multivariate analyses revealed that the only prognostic factor was macroscopic residual tumor (P=0.022). Although chemotherapy was not a prognostic factor (P=0.16), those who received intra-peritoneal chemotherapy tended to have a better prognosis than those who received systemic or no chemotherapy (P=0.064). In conclusion, the macroscopic residual tumor is an important prognostic factor in Japanese patients with PMP.
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- 2011
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17. Atypical Cogan's syndrome with aortitis.
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Kondo Y, Ito S, Ohi Y, Satou H, Hiraoka T, Tsuboi H, Sugihara M, Hayashi T, Goto D, Matsumoto I, and Sumida T
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- Adrenal Cortex Hormones therapeutic use, Aortitis diagnosis, Female, Humans, Keratitis diagnosis, Keratitis drug therapy, Meniere Disease diagnosis, Meniere Disease drug therapy, Middle Aged, Syndrome, Treatment Outcome, Vestibular Diseases diagnosis, Vestibular Diseases drug therapy, Aortitis complications, Keratitis complications, Meniere Disease complications, Vestibular Diseases complications
- Abstract
Cogan's syndrome is characterized by non syphilitic interstitial keratitis and Meniere's syndrome-like audiovestibular function disorder, as well as various systemic manifestations, including fever, arthralgia, vasculitis, and aortitis. We report the case of atypical Cogan's syndrome with aortitis; the patient's symptoms caused by active inflammation, including inflammatory ocular manifestations, audiovestibular symptoms, and aortitis, were improved by early administration of corticosteroids, however, her reduced visual acuity was not improved because of post-inflammatory change in her left eye.
- Published
- 2009
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18. Hydration structures of bromides on cationic micelles.
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Harada M, Satou H, and Okada T
- Abstract
The peripheral structures of bromides on dodecyltrimethylammonium bromide (DTAB) and hexadecyltrimethylammonium bromide (HTAB) micelles have been studied by X-ray absorption fine structure (XAFS) at the Br-K edge. The XAFS spectra indicate that water is a dominant scattering group for Br- even in these micellar solutions. However, the oscillation intensity decreases with increasing micellar concentration, suggesting that the bromides are dehydrated to some extent when they are bound to the micelles. A XAFS analysis routine gives unusually short Br-O (water) distances and is inapplicable to the present systems. This comes from the structure of the first coordination shell, in which two or more scattering paths are involved. The second scattering group is obviously the head group of the surfactants forming the micelles. The detailed analysis has allowed us to estimate the hydration number of the bromides bound on the DTAB and HTAB micelles (N = ca. 4.2). The assumption that all of the bromides form direct ion-associates with the head groups causes the contradiction to the results of the XAFS analyses. This strongly implies that some of the bromides partitioned into the micelle are completely hydrated as far as their first coordination shell is concerned. Assuming that the maximum hydration number of the bromides bound to the head groups of the micelle is three, 40% of the bromides partitioned into the micelle are completely hydrated.
- Published
- 2007
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19. Coronary flow characteristics of multiple coronary artery-left ventricular microfistulae in young monozygotic twins.
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Itoi T, Satou H, and Hamaoka K
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- Child, Coronary Vessels pathology, Fistula pathology, Heart Defects, Congenital pathology, Heart Ventricles pathology, Humans, Hypertrophy, Left Ventricular pathology, Male, Twins, Monozygotic, Coronary Circulation, Coronary Vessels physiopathology, Fistula physiopathology, Heart Defects, Congenital physiopathology, Heart Ventricles physiopathology, Hypertrophy, Left Ventricular physiopathology
- Abstract
Coronary artery multiple fistulae of the left ventricular chamber are extremely rare congenital malformations. We report on 13-year-old monozygotic twin brothers who have identical abnormalities of coronary flow reserve as well as the same morphological findings of multiple coronary fistulae of the 3 major coronary arteries to the left ventricular chamber. The left circumflex coronary artery (LCX) had abundant fine communications with the left ventricular chamber and had a higher flow rate than the left anterior-descending coronary artery. The coronary flow reserve obtained from the LCX was lower than the normal value matched for the same age group. The increased shunt flow resulted in enlargement of the left ventricular chamber. This is the first report of coronary flow characteristics in children with multiple coronary fistulae.
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- 2007
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20. Reaction paths of the water-assisted solvolysis of N,N-dimethylformamide.
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Tsuchida N, Satou H, and Yamabe S
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- Hydrolysis, Solubility, Thermodynamics, Dimethylformamide chemistry, Models, Chemical, Models, Molecular, Water chemistry
- Abstract
Density functional theory calculations were conducted on the title reactions with explicit inclusion of a variety of water molecules, H-CO-NMe2+MeOH+(H2O)n-->H-CO-OMe+HNMe2+(H2O)n. Geometries of transition states, reactant-like complexes and product-like ones were determined by the use of RB3LYP/6-31G(d) SCRF=dipole. Concerted paths were examined with n=0-3. Their Gibbs activation energies are larger than the experimental value. Stepwise paths were also investigated with n=2-4. The n=4 model has the energy close to the experimental value. However, when the catalytic water molecules were added to the n=4 one, the stepwise path was switched to the concerted one. A systematic comparison of the concerted path with n=2+1, 2+2, 2+3, 2+4, 2+5, 2+4+4, and 2+5+5 models was made, and the water-dimer based reaction path was found to be most favorable. The contrast between the concerted path of the amide solvolysis (and hydrolysis) and the stepwise one of the ester hydrolysis was discussed in terms of the frontier-orbital theory.
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- 2007
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21. A new immunoglobulin-binding protein, EibG, is responsible for the chain-like adhesion phenotype of locus of enterocyte effacement-negative, shiga toxin-producing Escherichia coli.
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Lu Y, Iyoda S, Satou H, Satou H, Itoh K, Saitoh T, and Watanabe H
- Subjects
- Adhesins, Escherichia coli chemistry, Adhesins, Escherichia coli genetics, Amino Acid Sequence, Cells, Cultured, DNA Transposable Elements, Diarrhea immunology, Diarrhea microbiology, Enterocytes microbiology, Escherichia coli genetics, Escherichia coli isolation & purification, Escherichia coli Infections immunology, Escherichia coli Infections microbiology, Escherichia coli Proteins genetics, Humans, Lymphokines genetics, Molecular Sequence Data, Mutagenesis, Insertional, Phosphoproteins genetics, Transformation, Genetic, Adhesins, Escherichia coli metabolism, Bacterial Adhesion, Escherichia coli pathogenicity, Escherichia coli Proteins metabolism, Lymphokines metabolism, Shiga Toxin biosynthesis
- Abstract
Shiga toxin-producing Escherichia coli (STEC) are important enteropathogens causing severe diseases such as hemorrhagic colitis and hemolytic-uremic syndrome in humans. The majority of STEC strains of serogroups O157, O26, or O111 associated with severe cases of these diseases possess a pathogenicity island termed the locus of enterocyte effacement (LEE). LEE, which is responsible for the formation of attaching-and-effacing lesions on intestinal epithelial cells, is important for the full virulence of STEC. Nonetheless, LEE-negative STEC strains have repeatedly been reported to be associated with severe diseases in humans. In this study, we characterized adhesion to cultured epithelial cells of certain LEE-negative STEC isolated from humans with or without bloody diarrhea. Several LEE-negative STEC belonging to serogroup O91 showed an unusual, chain-like adhesion pattern to HEp-2 cells. Using Tn5-based transposon mutagenesis, we identified the gene essential for the chain-like adhesion phenotype of this O91 STEC strain. Sequence analysis of the Tn5-inserted allele identified a novel chromosomal open reading frame (ORF) encoding a polypeptide with a high degree of similarity to the E. coli immunoglobulin-binding (Eib) proteins EibA, -C, -D, -E, and -F. Therefore, the ORF was designated EibG. Laboratory E. coli strain MC4100 transformed with a multicopy plasmid carrying eibG showed chain-like adhesion to HEp-2 cells, and whole-cell lysates of the strain bound to human-derived immunoglobulin G (IgG) Fc and IgA. These results indicate that EibG acts as an IgG Fc- and IgA-binding protein, as well as an adhesin of LEE-negative STEC.
- Published
- 2006
- Full Text
- View/download PDF
22. The GrlR-GrlA regulatory system coordinately controls the expression of flagellar and LEE-encoded type III protein secretion systems in enterohemorrhagic Escherichia coli.
- Author
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Iyoda S, Koizumi N, Satou H, Lu Y, Saitoh T, Ohnishi M, and Watanabe H
- Subjects
- Bacterial Adhesion physiology, DNA-Binding Proteins genetics, DNA-Binding Proteins metabolism, Endopeptidase Clp genetics, Endopeptidase Clp metabolism, Escherichia coli Proteins genetics, Flagellin genetics, Gene Deletion, Gene Expression Regulation, Bacterial, HeLa Cells, Humans, Operon genetics, Operon physiology, Phosphoproteins genetics, Repressor Proteins genetics, Trans-Activators genetics, Transcription, Genetic, Escherichia coli genetics, Escherichia coli metabolism, Escherichia coli Proteins metabolism, Flagellin metabolism, Phosphoproteins metabolism, Repressor Proteins metabolism, Trans-Activators metabolism
- Abstract
The gene function of the locus of enterocyte effacement (LEE) is essential for full virulence of enterohemorrhagic Escherichia coli (EHEC). Strict control of LEE gene expression is mediated by the coordinated activities of several regulatory elements. We previously reported that the ClpX/ClpP protease positively controls LEE expression by down-regulating intracellular levels of GrlR, a negative regulator of LEE gene expression. We further revealed that the negative effect of GrlR on LEE expression was mediated through GrlA, a positive regulator of LEE expression. In this study, we found that the FliC protein, a major component of flagellar filament, was overproduced in clpXP mutant EHEC, as previously reported for Salmonella. We further found that FliC expression was reduced in a clpXP grlR double mutant. To determine the mediators of this phenotype, FliC protein levels in wild-type, grlR, grlA, and grlR grlA strains were compared. Steady-state levels of FliC protein were reduced only in the grlR mutant, suggesting that positive regulation of FliC expression by GrlR is mediated by GrlA. Correspondingly, cell motility was also reduced in the grlR mutant, but not in the grlA or grlR grlA mutant. Because overexpression of grlA from a multicopy plasmid strongly represses the FliC level, as well as cell motility, we conclude that GrlA acts as a negative regulator of flagellar-gene expression. The fact that an EHEC strain constitutively expressing FlhD/FlhC cannot adhere to HeLa cells leads us to hypothesize that GrlA-dependent repression of the flagellar regulon is important for efficient cell adhesion of EHEC to host cells.
- Published
- 2006
- Full Text
- View/download PDF
23. Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4alpha gene.
- Author
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Hara K, Noda M, Waki H, Tobe K, Yamauchi T, Kadowaki H, Satou H, Tsukamoto K, Nagamatsu S, Yamagata K, Matsuzawa Y, Akanuma Y, Kimura S, and Kadowaki T
- Subjects
- Adult, Age of Onset, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Blood Glucose analysis, DNA-Binding Proteins genetics, Diabetes Mellitus, Type 2 physiopathology, Female, Genes, Dominant genetics, Glucose Tolerance Test, Hepatocyte Nuclear Factor 4, Humans, Middle Aged, Pedigree, Transcription, Genetic physiology, Diabetes Mellitus, Type 2 genetics, Mutation, Phosphoproteins genetics, Transcription Factors genetics
- Abstract
A 52-year-old woman with early-onset diabetes mellitus, severe diabetic retinopathy, and a family history of a dominant inheritance pattern was referred to our hospital. Direct sequencing revealed a novel mutation in the HNF-4alpha gene (R244Q). The position of the mutation in the amino-acid sequence of the gene is well conserved among species and transcriptional activity of the mutant gene was significantly reduced. Therefore, a diagnosis of maturity-onset diabetes of the young (MODY)-1 was made. Genetic testing enabled early diagnosis of diabetes in the patient's 20-year-old daughter, which we consider to be important for the prevention of diabetic complications.
- Published
- 2002
- Full Text
- View/download PDF
24. Intraosseous meningioma of the posterior fossa--Case report.
- Author
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Yamazaki T, Tsukada A, Uemura K, Satou H, Tsuboi K, and Nose T
- Subjects
- Cerebral Angiography, Cranial Fossa, Posterior diagnostic imaging, Epidural Space, Humans, Magnetic Resonance Imaging, Male, Meningeal Neoplasms diagnostic imaging, Meningeal Neoplasms surgery, Meningioma diagnostic imaging, Meningioma surgery, Middle Aged, Occipital Bone diagnostic imaging, Skull Neoplasms diagnostic imaging, Skull Neoplasms surgery, Tomography, X-Ray Computed, Cranial Fossa, Posterior pathology, Meningeal Neoplasms pathology, Meningioma pathology, Occipital Bone pathology, Skull Neoplasms pathology
- Abstract
A 62-year-old male presented with a rare intraosseous meningioma with intradural extension manifesting as frequent vomiting and floating sensation that had persisted for 3 months. Neuroimaging detected a mass lesion that was mainly located extradurally in the right posterior fossa with a daughter lesion inside the dura. He underwent surgical excision of the mass lesion. Craniectomy exposed the main lesion of the tumor just beneath the thinned outer table of the skull, and in the extradural space, with the daughter lesion penetrating the dura. Both portions of the tumor were resected. There was no attachment to the adjacent dura mater. Histological examination showed meningotheliomatous meningioma containing scattered bony tissue. This intraosseous meningioma probably originated from the occipital bone with a small intradural extension caused by mechanical compression.
- Published
- 2001
- Full Text
- View/download PDF
25. Isolated left coronary ostial stenosis as a result of fibromuscular dysplasia in a young man.
- Author
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Kawakami H, Matsuoka H, Koyama Y, Saeki H, Inoue K, Nishimura K, Itou T, Satou H, and Tomino T
- Subjects
- Adult, Angina Pectoris etiology, Angina Pectoris pathology, Angina Pectoris surgery, Coronary Angiography, Coronary Disease pathology, Coronary Disease surgery, Fibromuscular Dysplasia pathology, Fibromuscular Dysplasia surgery, Humans, Male, Coronary Disease etiology, Fibromuscular Dysplasia complications
- Abstract
A 28-year-old man was admitted to hospital for investigation of a 2-week history of angina occurring on exertion. Coronary angiography showed an isolated left coronary ostial stenosis and left main trunk plasty was performed 2 weeks later. The pathological diagnosis of the left coronary ostial stenosis was fibromuscular dysplasia, which makes this a rare case.
- Published
- 2000
- Full Text
- View/download PDF
26. Three-dimensional imaging of aortic aneurysm after balloon angioplasty for coarctation of the aorta.
- Author
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Hamaoka K, Satou H, Sakata K, and Onouchi Z
- Subjects
- Adolescent, Aortic Aneurysm, Abdominal etiology, Aortic Aneurysm, Abdominal surgery, Aortic Valve Stenosis etiology, Aortic Valve Stenosis surgery, Aortography, Female, Heart Septal Defects, Ventricular surgery, Humans, Magnetic Resonance Imaging, Postoperative Complications etiology, Postoperative Complications surgery, Angioplasty, Balloon adverse effects, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Coarctation surgery, Tomography, X-Ray Computed methods
- Published
- 1999
- Full Text
- View/download PDF
27. Association between family history and gastric carcinoma among young adults.
- Author
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Kikuchi S, Nakajima T, Nishi T, Kobayashi O, Konishi T, Inaba Y, Wada O, Satou H, Ishibashi T, Ichikawa S, Okamoto N, Hirata T, Kubo T, Sato N, Miki K, and Myoga A
- Subjects
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Analysis of Variance, Child, Family Health, Female, Humans, Incidence, Japan epidemiology, Male, Middle Aged, Stomach Neoplasms epidemiology, Stomach Neoplasms genetics
- Abstract
The relationship between family history of gastric carcinoma and gastric carcinoma in Japanese under 40 years of age was analyzed. The subjects were 108 gastric carcinoma patients (86% were diffuse type) at 9 hospitals in the Kanto area of Japan. Firstly, incidence of gastric carcinoma among the parents of the subjects were compared with that in the general population. Observed/expected (O/E) ratios (P-value) were 1.8 (0.06) for all subjects, 1.3 (0.62) for male subjects, 2.1 (0.04) for female subjects, 0.5 (0.41) for early carcinoma, 2.6 (P<0.01) for advanced carcinoma, 2.3 (0.22) for intestinal-type carcinoma and 1.7 (0.13) for diffuse-type carcinoma. Association between gastric carcinoma and parents' history of gastric carcinoma was strong among women and regarding advanced carcinoma, and the difference in O/E ratios between early and advanced carcinoma was remarkable. Secondly, factors related to advanced-stage gastric carcinoma were analyzed. Histological type (diffuse and intestinal types) was not related, but family history of gastric carcinoma among parents and grandparents was related to advanced stage, and the relationship was independent of other factors. The odds ratio (95% confidence interval) was 3.3 (1.1-9.9). Family history may be related to stage of gastric carcinoma through its relationship to the manner or speed of the tumor's progression. We hypothesis that some genetic factor exists which is involved both in progression from early to advanced stage and in occurrence of gastric carcinoma.
- Published
- 1996
- Full Text
- View/download PDF
28. Electrophysiological effects of disopyramide phosphate in patients with sinus node dysfunction.
- Author
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Tsuchioka Y, Mitsuda H, Eno S, Fujitani K, Furuta Y, Yoshida M, Miyoshi A, Tateishi H, and Satou H
- Subjects
- Arrhythmias, Cardiac drug therapy, Disopyramide analogs & derivatives, Electric Stimulation, Electrocardiography, Female, Heart Rate drug effects, Humans, Male, Middle Aged, Sinoatrial Block physiopathology, Sinoatrial Node drug effects, Arrhythmias, Cardiac physiopathology, Disopyramide pharmacology, Pyridines pharmacology, Sinoatrial Node physiopathology
- Abstract
The electrophysiological effects of intravenous administration of disopyramide (1.5 mg/kg) were studied in 26 patients with sinus node dysfunction (SND). Disopyramide shortened spontaneous cycle length (SCL) in 12 patients and lengthened it in 4. Maximum sinus node recovery time (max SRT) was prolonged in 9 patients and shortened in 6. Estimated sinoatrial conduction time (SACT) was prolonged in 4 and shortened in 4 out of 10 patients in whom this measurement was possible. However, these changes were not statistically significant. Neither were there any significant changes in PA and AH intervals nor refractory periods of the AV node. HV intervals and refractory periods of the atrium at matched cycle length were significantly lengthened. Atrial echo beats and atrial premature beats disappeared in 7 of 12 patients treated with disopyramide. In all of these 7 patients atrial refractory period were increased. Thus, the disappearance of atrial echo beats and atrial premature beats was thought to be due to a prolonged atrial refractoriness. In 4 patients who had supraventricular arrhythmias without having either marked prolongation of max SRT or episodes of syncope, disopyramide was administered orally for a long term, during which these arrhythmias and symptoms disappeared and sinus rate increased. These results suggest that disopyramide is useful in patients with SND and supraventricular arrhythmias.
- Published
- 1982
- Full Text
- View/download PDF
29. Lack of carcinogenicity of 8-nitroquinoline on long-term in vivo test in hamsters.
- Author
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Furukawa F, Kishimoto Y, Toyoda K, Satou H, Takahashi M, and Hayashi Y
- Subjects
- Administration, Oral, Animals, Body Weight drug effects, Cricetinae, Female, Male, Mesocricetus, Nitroquinolines administration & dosage, Time Factors, Neoplasms, Experimental chemically induced, Nitroquinolines toxicity
- Abstract
Syrian golden hamsters were administered 8-nitroquinoline, at a concentration of 0.05%, in a 10% ethanol solution as drinking water for 104 weeks. The animals were kept under observation until 112 weeks of age when the experiment was terminated. Both control and treated groups developed tumors in a pattern indistinguishable from that usually observed in Syrian golden hamsters. Thus the result of this experiment indicates that 8-nitroquinoline given orally at a concentration of 0.05% is not carcinogenic in Syrian golden hamsters.
- Published
- 1985
- Full Text
- View/download PDF
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