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18 results on '"Savi, Arianna"'

1. Applicability of 2022 classifications of acute myeloid leukemia in the real-world setting

Author

Attardi, Enrico, Savi, Arianna, Borsellino, Beatrice, Piciocchi, Alfonso, Cipriani, Marta, Ottone, Tiziana, Fabiani, Emiliano, Divona, Mariadomenica, Travaglini, Serena, Pascale, Maria Rosaria, Awada, Hussein, Durmaz, Arda, Visconte, Valeria, Della Porta, Matteo Giovanni, Venditti, Adriano, Maciejewski, Jaroslaw P., Gurnari, Carmelo, and Voso, Maria Teresa

Published
2023
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3. Detection of KIT Mutations in Systemic Mastocytosis: How, When, and Why.

Author

Cilloni, Daniela, Maffeo, Beatrice, Savi, Arianna, Danzero, Alice Costanza, Bonuomo, Valentina, and Fava, Carmen

Subjects
NUCLEOTIDE sequencing, MAST cells, GENE frequency, GENETIC mutation, MAST cell disease
Abstract

More than 90% of patients affected by mastocytosis are characterized by a somatic point mutation of KIT, which induces ligand-independent activation of the receptor and downstream signal triggering, ultimately leading to mast cell accumulation and survival. The most frequent mutation is KIT p.D816V, but other rarer mutations can also be found. These mutations often have a very low variant allele frequency (VAF), well below the sensitivity of common next-generation sequencing (NGS) methods used in routine diagnostic panels. Highly sensitive methods are developing for detecting mutations. This review summarizes the current indications on the recommended methods and on how to manage and interpret molecular data for the diagnosis and follow-up of patients with mastocytosis. [ABSTRACT FROM AUTHOR]

Published
2024
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4. P499: APPLICABILITY OF 2022 CLASSIFICATIONS OF ACUTE MYELOID LEUKEMIA IN THE REAL-WORLD SETTING

Author

Attardi, Enrico, primary, Savi, Arianna, additional, Borsellino, Beatrice, additional, Piciocchi, Alfonso, additional, Cipriani, Marta, additional, Ottone, Tiziana, additional, Fabiani, Emiliano, additional, Divona, Mariadomenica, additional, Travaglini, Serena, additional, Rosaria Pascale, Maria, additional, Durmaz, Arda, additional, Visconte, Valeria, additional, Giovanni Della Porta, Matteo, additional, Venditti, Adriano, additional, P Maciejewski, Jaroslaw, additional, Gurnari, Carmelo, additional, and Teresa Voso, Maria, additional

Published
2023
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6. FEVER OF UNKNOWN ORIGIN AND MULTIDRUG-RESISTANT ORGANISMS COLONIZATION IN AML PATIENTS.

Author

Guarnera, Luca, primary, Trotta, Gentiana Elena, additional, Boldrini, Valentina, additional, Cardillo, Lucia, additional, Cerroni, Ilaria, additional, Mezzanotte, Valeria, additional, Pasqualone, Gianmario, additional, Savi, Arianna, additional, Borsellino, Beatrice, additional, Buzzatti, Elisa, additional, Palmieri, Raffaele, additional, Paterno, Giovangiacinto, additional, Maurillo, Luca, additional, Buccisano, Francesco, additional, Venditti, Adriano, additional, and Del Principe, Maria Ilaria, additional

Published
2023
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7. Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience

Author

Paterno, Giovangiacinto, primary, Palmieri, Raffaele, additional, Forte, Vittorio, additional, Del Prete, Valentina, additional, Gurnari, Carmelo, additional, Guarnera, Luca, additional, Mallegni, Flavia, additional, Pascale, Maria Rosaria, additional, Buzzatti, Elisa, additional, Mezzanotte, Valeria, additional, Cerroni, Ilaria, additional, Savi, Arianna, additional, Buccisano, Francesco, additional, Maurillo, Luca, additional, Venditti, Adriano, additional, and Del Principe, Maria Ilaria, additional

Published
2022
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8. Case report: A Saprochaete clavata (Magnusiomyces clavatus) severe infection effectively treated with granulocyte transfusion in a young patient with myeloid sarcoma

Author

Pasqualone, Gianmario, primary, Buzzatti, Elisa, additional, Palmieri, Raffaele, additional, Savi, Arianna, additional, Pascale, Maria Rosaria, additional, Borsellino, Beatrice, additional, Guarnera, Luca, additional, Buccisano, Francesco, additional, Voso, Maria Teresa, additional, Maurillo, Luca, additional, Sconocchia, Giuseppe, additional, Venditti, Adriano, additional, and Del Principe, Maria Ilaria, additional

Published
2022
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10. Can Polycythemia Vera evolve from Acute Myeloid Leukemia? A Case Report Showing a Simultaneous Minor JAK2 V617F Mutated Clone,

Author

Borsellino, Beatrice, primary, Savi, Arianna, additional, Pascale, Maria Rosaria, additional, Meddi, Elisa, additional, Cristiano, Antonio, additional, OTTONE, TIZIANA, additional, Rapanotti, Maria Cristina, additional, Divona, Mariadomenica, additional, TRAVAGLINI, SERENA, additional, Attardi, Enrico, additional, Buzzatti, Elisa, additional, Buccisano, Francesco, additional, and Voso, Maria Teresa, additional

Published
2022
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11. The venetoclax/azacitidine combination targets the disease clone in Acute Myeloid Leukemia, being effective and safe in a patient with COVID

Author

Cristiano, Antonio, primary, Palmieri, Raffaele, additional, Fabiani, Emiliano, additional, Ottone, Tiziana, additional, Divona, Mariadomenica, additional, Savi, Arianna, additional, Buccisano, Francesco, additional, Maurillo, Luca, additional, Tarella, Corrado, additional, Arcese, William, additional, and Voso, Maria Teresa, additional

Published
2022
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13. In BCR-ABL1 Positive B-Cell Acute Lymphoblastic Leukemia, Steroid Therapy Induces Hypofibrinogenemia

Author

Buzzatti, Elisa, primary, Forghieri, Fabio, additional, Paterno, Giovangiacinto, additional, Marchesi, Francesco, additional, Sarlo, Chiara, additional, Giglio, Fabio, additional, Fracchiolla, Nicola, additional, Sciumè, Mariarita, additional, Palmieri, Raffaele, additional, Esposito, Fabiana, additional, Guarnera, Luca, additional, Mercante, Lisa, additional, Pascale, Maria Rosaria, additional, Mallegni, Flavia, additional, Savi, Arianna, additional, Forte, Vittorio, additional, Maurillo, Luca, additional, Buccisano, Francesco, additional, Venditti, Adriano, additional, and Del Principe, Maria Ilaria, additional

Published
2022
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15. Can Polycythemia Vera Evolve from Acute Myeloid Leukemia? Report of a Case Showing a Simultaneous Minor JAK2 V617F Mutated Clone.

Author

Borsellino, Beatrice, Savi, Arianna, Pascale, Maria Rosaria, Meddi, Elisa, Del Principe, Maria Ilaria, Cristiano, Antonio, Ottone, Tiziana, Rapanotti, Maria Cristina, Divona, Mariadomenica, Travaglini, Serena, Attardi, Enrico, Palmieri, Raffaele, Buzzatti, Elisa, Buccisano, Francesco, and Voso, Maria Teresa

Subjects
*POLYCYTHEMIA vera, *ACUTE myeloid leukemia, *MOLECULAR cloning, *MYELOPROLIFERATIVE neoplasms, *BONE marrow
Abstract

The evolution of myeloproliferative neoplasms (MPN) to acute myeloid leukemia (AML) occurs in 2-10% of patients, depending on the MPN subtype, treatment, and follow-up length. The reverse-path from AML to MPN has been rarely reported. We herein present a 75 years old woman with AML, in whom a JAK2-V617F positive polycythemia vera (PV) emerged during follow-up, 19 months from the end of consolidation treatment. JAK2-V617F mutation screening retrospectively performed by Next Generation Sequencing (NGS) and JAK2 MutaScreen was negative on the bone marrow sample collected at AML diagnosis. However, using digital droplet PCR (ddPCR), we detected a minor JAK2 V617F mutated clone at AML onset. In addition, a TET2 R550 mutated clone persisted at stable levels throughout the disease course. This case shows that a very small MPN clone masked at AML diagnosis may expand after treatment end and be erroneously interpreted as MPN evolving from AML. Very sensitive techniques such as ddPCR may help to unravel the true disease history in these cases. [ABSTRACT FROM AUTHOR]

Published
2022
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18. An Polycythemia Vera Evolve from Acute Myeloid Leukemia? Report of a Case Showing a Simultaneous Minor JAK2 V617F Mutated Clone.

Author

Borsellino B, Savi A, Pascale MR, Meddi E, Del Principe MI, Cristiano A, Ottone T, Rapanotti MC, Divona M, Travaglini S, Attardi E, Palmieri R, Buzzatti E, Buccisano F, and Voso MT

Abstract

The evolution of myeloproliferative neoplasms (MPN) to acute myeloid leukemia (AML) occurs in 2-10% of patients, depending on the MPN subtype, treatment, and follow-up length. The reverse-path from AML to MPN has been rarely reported. We herein present a 75 years old woman with AML, in whom a JAK2 -V617F positive polycythemia vera (PV) emerged during follow-up, 19 months from the end of consolidation treatment. JAK2- V617F mutation screening retrospectively performed by Next Generation Sequencing (NGS) and JAK2 MutaScreen was negative on the bone marrow sample collected at AML diagnosis. However, using digital droplet PCR (ddPCR), we detected a minor JAK2 V617F mutated clone at AML onset. In addition, a TET2 R550 mutated clone persisted at stable levels throughout the disease course. This case shows that a very small MPN clone masked at AML diagnosis may expand after treatment end and be erroneously interpreted as MPN evolving from AML. Very sensitive techniques such as ddPCR may help to unravel the true disease history in these cases., Competing Interests: Competing interests: The authors declare no conflict of Interest.

Published
2022
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