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2. Angle-resolved photoelectron spectroscopy in a low energy electron microscope

Author

Neuhaus, Alexander, Dreher, Pascal, Schütz, Florian, Marchetto, Helder, Franz, Torsten, and Heringdorf, Frank-J. Meyer zu

Subjects
Condensed Matter - Materials Science, Physics - Instrumentation and Detectors
Abstract

Spectroscopic photoemission microscopy is a well-established method to investigate the electronic structure of surfaces. In modern photoemission microscopes the electron optics allows imaging of the image plane, momentum plane, or dispersive plane, depending on the lens setting. Furthermore, apertures allow filtering of energy-, real-, and momentum space. Here, we describe how a standard spectroscopic and low energy electron microscope can be equipped with an additional slit at the entrance of the already present hemispherical analyzer to enable an angle- and energy resolved photoemission mode with micrometer spatial selectivity. We apply a photogrammetric calibration to correct for image distortions of the projective system behind the analyzer and present spectra recorded on Au(111) as a benchmark. Our approach makes data acquisition in energy-momentum space more efficient, which is a necessity for laser-based pump-probe photoemission microscopy with femtosecond time resolution., Comment: This manuscript has been peer-reviewed and is currently undergoing revision

Published
2023
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5. RNA Sequencing of Carboplatin- and Paclitaxel-Resistant Endometrial Cancer Cells Reveals New Stratification Markers and Molecular Targets for Cancer Treatment.

Author

Hellweg, Raffaele, Mooneyham, Ashley, Chang, Zenas, Shetty, Mihir, Emmings, Edith, Iizuka, Yoshie, Clark, Christopher, Starr, Timothy, Abrahante, Juan, Schütz, Florian, Konecny, Gottfried, Argenta, Peter, and Bazzaro, Martina

Subjects
Chemoresistance, Endometrial cancer, Gene expression, Recurrence, Biomarkers, Carboplatin, Endometrial Neoplasms, Female, Humans, Paclitaxel, Sequence Analysis, RNA
Abstract

Despite advances in surgical technique and adjuvant treatment, endometrial cancer has recently seen an increase in incidence and mortality in the USA. The majority of endometrial cancers can be cured by surgery alone or in combination with adjuvant chemo- or radiotherapy; however, a subset of patients experience recurrence for reasons that remain unclear. Recurrence is associated with chemoresistance to carboplatin and paclitaxel and consequentially, high mortality. Understanding the pathways involved in endometrial cancer chemoresistance is paramount for the identification of biomarkers and novel molecular targets for this disease. Here, we generated the first matched pairs of carboplatin-sensitive/carboplatin-resistant and paclitaxel-sensitive/paclitaxel-resistant endometrial cancer cells and subjected them to bulk RNA sequencing analysis. We found that 45 genes are commonly upregulated in carboplatin- and paclitaxel-resistant cells as compared to controls. Of these, the leukemia inhibitory factor, (LIF), the protein tyrosine phosphatase type IVA, member 3 (PTP4A3), and the transforming growth factor beta 1 (TGFB1) showed a highly significant correlation between expression level and endometrial cancer overall survival (OS) and can stratify the 545 endometrial cancer patients in the TCGA cohort into a high-risk and low-risk-cohorts. Additionally, four genes within the 45 upregulated chemoresistance-associated genes are ADAMTS5, MICAL2, STAT5A, and PTP4A3 codes for proteins for which small-molecule inhibitors already exist. We identified these proteins as molecular targets for chemoresistant endometrial cancer and showed that treatment with their correspondent inhibitors effectively killed otherwise chemoresistant cells. Collectively, these findings underline the utility of matched pair of chemosensitive and chemoresistant cancer cells to identify markers for endometrial cancer risk stratification and to serve as a pharmacogenomics model for identification of alternative chemotherapy approaches for treatment of patients with recurrent disease.

Published
2018

6. Update Breast Cancer 2024 Part 1 – Expert Opinion on Advanced Breast Cancer

Author

Würstlein, Rachel, additional, Kolberg, Hans-Christian, additional, Hartkopf, Andreas D., additional, Fehm, Tanja N., additional, Welslau, Manfred, additional, Schütz, Florian, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Witzel, Isabell, additional, Thomssen, Christoph, additional, Krückel, Annika, additional, Belleville, Erik, additional, Lüftner, Diana, additional, Untch, Michael, additional, Thill, Marc, additional, Hörner, Manuel, additional, Tesch, Hans, additional, Ditsch, Nina, additional, Lux, Michael P., additional, Aktas, Bahriye, additional, Banys-Paluchowski, Maggie, additional, Taran, Florin-Andrei, additional, Wöckel, Achim, additional, Harbeck, Nadia, additional, Stickeler, Elmar, additional, Bartsch, Rupert, additional, Schneeweiss, Andreas, additional, Ettl, Johannes, additional, Krug, David, additional, and Müller, Volkmar, additional

Published
2024
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7. Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

Author

Xydia, Maria, Rahbari, Raheleh, Ruggiero, Eliana, Macaulay, Iain, Tarabichi, Maxime, Lohmayer, Robert, Wilkening, Stefan, Michels, Tillmann, Brown, Daniel, Vanuytven, Sebastiaan, Mastitskaya, Svetlana, Laidlaw, Sean, Grabe, Niels, Pritsch, Maria, Fronza, Raffaele, Hexel, Klaus, Schmitt, Steffen, Müller-Steinhardt, Michael, Halama, Niels, Domschke, Christoph, Schmidt, Manfred, von Kalle, Christof, Schütz, Florian, Voet, Thierry, and Beckhove, Philipp

Published
2021
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9. Dynamic structure factor of Luttinger liquids with quadratic energy dispersion and long-range interactions

Author

Pirooznia, Peyman, Schuetz, Florian, and Kopietz, Peter

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Statistical Mechanics
Abstract

We calculate the dynamic structure factor S (omega, q) of spinless fermions in one dimension with quadratic energy dispersion k^2/2m and long range density-density interaction whose Fourier transform f_q is dominated by small momentum-transfers q << q_0 << k_F. Here q_0 is a momentum-transfer cutoff and k_F is the Fermi momentum. Using functional bosonization and the known properties of symmetrized closed fermion loops, we obtain an expansion of the inverse irreducible polarization to second order in the small parameter q_0 / k_F. In contrast to perturbation theory based on conventional bosonization, our functional bosonization approach is not plagued by mass-shell singularities. For interactions which can be expanded as f_q = f_0 + f_0^{2} q^2/2 + O (q^4) with finite f_0^{2} we show that the momentum scale q_c = 1/ | m f_0^{2} | separates two regimes characterized by a different q-dependence of the width gamma_q of the collective zero sound mode and other features of S (omega, q). For q_c << q << k_F we find that the line-shape in this regime is non-Lorentzian with an overall width gamma_q of order q^3/(m q_c) and a threshold singularity at the lower edge., Comment: 33 Revtex pages, 17 figures

Published
2008
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10. Landau functions for non-interacting bosons

Author

Sinner, Andreas, Schuetz, Florian, and Kopietz, Peter

Subjects
Condensed Matter - Statistical Mechanics
Abstract

We discuss the statistics of Bose-Einstein condensation (BEC) in a canonical ensemble of N non-interacting bosons in terms of a Landau function L_N^{BEC} (q) defined by the logarithm of the probability distribution of the order parameter q for BEC. We also discuss the corresponding Landau function for spontaneous symmetry breaking (SSB), which for finite N should be distinguished from L_N^{BEC}. Only for intinite N BEC and SSB can be described by the same Landau function which depends on the dimensionality and on the form of the external potential in a surprisingly complex manner. For bosons confined by a three-dimensional harmonic trap the Landau function exhibits the usual behavior expected for continuous phase transitions., Comment: 4 pages, 4 figures; final version to appear as a rapid communication in Physical Review A. Abstract modified and typos corrected

Published
2006
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11. Functional renormalization group with vacuum expectation values and spontaneous symmetry breaking

Author

Schuetz, Florian and Kopietz, Peter

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Statistical Mechanics
Abstract

We generalize our recently developed super-field functional renormalization group (RG) method involving both Fermi and Bose fields [F. Schuetz, L. Bartosch, and P. Kopietz, Phys. Rev. B 72, 035105 (2005)] to include the possibility that some bosonic components of the field have a finite vacuum expectation value. We derive an exact hierarchy of flow equations for the one-line irreducible vertices and the vacuum expectation value of the field. We apply our method to an interacting Fermi system where the interaction can be decoupled in the zero-sound channel and is then mediated by a collective bosonic field. The vacuum expectation value of the zero-frequency and zero-momentum component of the bosonic field is then closely related to the fermionic density. This can be exploited to calculate the compressibility of the interacting system. By using a cutoff in the bosonic propagator, the RG can be set up such that the self-consistent Hartree approximation is imposed as initial condition for the RG flow and the corrections to this approximation are generated as the remaining degrees of freedom are successively eliminated by the RG procedure., Comment: 15 pages, 2 figures; published version, some typos corrected; special issue "Renormalization Group 2005" of JPA. (proc. of Helsinki conference)

Published
2005
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12. Effective spin-wave action for ordered Heisenberg antiferromagnets in a magnetic field

Author

Hasselmann, Nils, Schuetz, Florian, Spremo, Ivan, and Kopietz, Peter

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We derive the effective long-wavelength Euclidean action for the antiferromagnetic spin-waves of ordered quantum antiferromagnets subject to a uniform magnetic field. We point out that the magnetic field dependence of the spin-wave dispersion predicted by the usual O(3)-quantum nonlinear sigma model disagrees with spin-wave theory. We argue that the nonlinear sigma model does not take into account all relevant spin-wave interactions and derive a modified effective action for the long-wavelength spin-waves which contains an additional quartic interaction. At zero temperature the corresponding vertex is relevant in the renormalization group sense below three dimensions., Comment: 4 pages, 1 eps figure; proceedings of the symposium on "Spin- and charge-correlations in molecule-based materials", October 2005, Koenigstein (Taunus), Germany

Published
2005
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13. Magnetic properties of a metal-organic antiferromagnet on a distorted honeycomb lattice

Author

Spremo, Ivan, Schuetz, Florian, Kopietz, Peter, Pashchenko, Volodymyr, Wolf, Bernd, Lang, Michael, Bats, Jan W., Hu, Chunhua, and Schmidt, Martin U.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

For temperatures T well above the ordering temperature T*=3.0+-0.2K the magnetic properties of the metal-organic material Mn[C10H6(OH)(COO)]2x2H20 built from Mn^2+ ions and 3-hydroxy-2-naphthoic anions can be described by a S=5/2 quantum antiferromagnet on a distorted honeycomb lattice with two different nearest neighbor exchange couplings J2 \approx 2J1 \approx 1.8K. Measurements of the magnetization M(H,T) as a function of a uniform external field H and of the uniform zero field susceptibility \chi(T) are explained within the framework of a modified spin-wave approach which takes into account the absence of a spontaneous staggered magnetization at finite temperatures., Comment: 11 pages, 11 figures; more thorough discussion of the dependence of the correlation length on the uniform magnetic field added

Published
2005
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14. Collective fields in the functional renormalization group for fermions, Ward identities, and the exact solution of the Tomonaga-Luttinger model

Author

Schuetz, Florian, Bartosch, Lorenz, and Kopietz, Peter

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Statistical Mechanics, High Energy Physics - Theory
Abstract

We develop a new formulation of the functional renormalization group (RG) for interacting fermions. Our approach unifies the purely fermionic formulation based on the Grassmannian functional integral, which has been used in recent years by many authors, with the traditional Wilsonian RG approach to quantum systems pioneered by Hertz [Phys. Rev. B 14, 1165 (1976)], which attempts to describe the infrared behavior of the system in terms of an effective bosonic theory associated with the soft modes of the underlying fermionic problem. In our approach, we decouple the interaction by means of a suitable Hubbard-Stratonovich transformation (following the Hertz-approach), but do not eliminate the fermions; instead, we derive an exact hierarchy of RG flow equations for the irreducible vertices of the resulting coupled field theory involving both fermionic and bosonic fields. The freedom of choosing a momentum transfer cutoff for the bosonic soft modes in addition to the usual band cutoff for the fermions opens the possibility of new RG schemes. In particular, we show how the exact solution of the Tomonaga-Luttinger model emerges from the functional RG if one works with a momentum transfer cutoff. Then the Ward identities associated with the local particle conservation at each Fermi point are valid at every stage of the RG flow and provide a solution of an infinite hierarchy of flow equations for the irreducible vertices. The RG flow equation for the irreducible single-particle self-energy can then be closed and can be reduced to a linear integro-differential equation, the solution of which yields the result familiar from bosonization. We suggest new truncation schemes of the exact hierarchy of flow equations, which might be useful even outside the weak coupling regime., Comment: 27 pages, 15 figures; published version, some typos corrected

Published
2004
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15. What are spin currents in Heisenberg magnets?

Author

Schuetz, Florian, Kopietz, Peter, and Kollar, Marcus

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract

We discuss the proper definition of the spin current operator in Heisenberg magnets subject to inhomogeneous magnetic fields. We argue that only the component of the naive "current operator" J_ij S_i x S_j in the plane spanned by the local order parameters and is related to real transport of magnetization. Within a mean field approximation or in the classical ground state the spin current therefore vanishes. Thus, finite spin currents are a direct manifestation of quantum correlations in the system., Comment: 4 pages, 1 figure, published version

Published
2004
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16. Persistent spin currents in mesoscopic Haldane gap spin rings

Author

Schuetz, Florian, Kollar, Marcus, and Kopietz, Peter

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract

Using a modified spin-wave approach, we show that in the presence of an inhomogeneous magnetic field or an in plane inhomogeneous electric field a mesoscopic antiferromagnetic Heisenberg ring with integer spin (i.e., a Haldane gap system) exhibits a persistent circulating spin current. Due to quantum fluctuations the current has a finite limit on the order of -g mu_B c/L at zero temperature, provided the staggered correlation length xi exceeds the circumference L of the ring, in close analogy to ballistic charge currents in mesoscopic normal metal rings. Here c is the spin-wave velocity, g is the gyromagnetic ratio and mu_B is the Bohr magneton. For xi<

Published
2003
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17. Persistent spin currents in mesoscopic Heisenberg rings

Author

Schuetz, Florian, Kollar, Marcus, and Kopietz, Peter

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract

We show that at low temperatures T an inhomogeneous radial magnetic field with magnitude B gives rise to a persistent magnetization current around a mesoscopic ferromagnetic Heisenberg ring. Under optimal conditions this spin current can be as large as g mu_B (T / hbar) exp [ - 2 pi (g mu_B B / Delta )^1/2 ], as obtained from leading-order spin-wave theory. Here g is the gyromagnetic factor, mu_B is the Bohr magneton, and Delta is the energy gap between the ground state and the first spin-wave excitation. The magnetization current endows the ring with an electric dipole moment., Comment: 4 pages, 3 figures, published version

Published
2003
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18. Prävention und Therapie der Frühgeburt : Leitlinie der DGGG, OEGGG und SGGG (S2k-Level, AWMF-Registernummer 015/025, September 2022) – Teil 1 mit Empfehlungen zur Epidemiologie, Ätiologie, Prädiktion, primären und sekundären Prävention der Frühgeburt

Author

Berger, Richard, Abele, Harald, Bahlmann, Franz, Doubek, Klaus, Felderhoff-Müser, Ursula, Fluhr, Herbert, Garnier, Yves, Grylka-Baeschlin, Susanne, Hayward, Aurelia, Helmer, Hanns, Herting, Egbert, Hoopmann, Markus, Hösli, Irene, Hoyme, Udo, Kunze, Mirjam, Kuon, Ruben-H., Kyvernitakis, Ioannis, Lütje, Wolf, Mader, Silke, Maul, Holger, Mendling, Werner, Mitschdörfer, Barbara, Nothacker, Monika, Olbertz, Dirk, Ramsell, Andrea, Rath, Werner, Roll, Claudia, Schlembach, Dietmar, Schleußner, Ekkehard, Schütz, Florian, Seifert-Klauss, Vanadin, Stubert, Johannes, and Surbek, Daniel

Subjects
Vorzeitige Wehentätigkeit, Preterm labor, Medizin, Obstetrics and Gynecology, Preterm birth, 618: Geburtsmedizin und Hebammenarbeit, Guideline, Frühgeburt, Früher vorzeitiger Blasensprung, Cervical insufficiency, Preterm premature rupture of membranes, Zervixinsuffizienz, Maternity and Midwifery, Leitlinie
Abstract

Artikel in mehreren Sprachen: Deutsch und Englisch Aim: This revised guideline was coordinated by the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (OEGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). It aims to improve the prediction, prevention, and management of preterm birth, based on evidence from the current literature, the experience of members of the guidelines commission, and the viewpoint of self-help organizations. Methods: The members of the contributing professional societies and organizations developed recommendations and statements based on international literature. The recommendations and statements were presented and adopted using a formal process (structured consensus conferences with neutral moderation, written Delphi vote). Recommendations: Part 1 of this short version of the guideline presents statements and recommendations on the epidemiology, etiology, prediction, and primary and secondary prevention of preterm birth. Ziel: Überarbeitete Leitlinie der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG), der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) und der Schweizerischen Gesellschaft für Gynäkologie und Geburtshilfe (SGGG). Ziel der Leitlinie ist es, die Prädiktion, die Prävention und das Management der Frühgeburt anhand der aktuellen Literatur, der Erfahrung der Mitglieder der Leitlinienkommission einschließlich der Sicht der Selbsthilfe evidenzbasiert zu verbessern. Methoden: Anhand der internationalen Literatur entwickelten die Mitglieder der beteiligten Fachgesellschaften und Organisationen zahlreiche Empfehlungen und Statements. Diese wurden in einem formalen Prozess (strukturierte Konsensuskonferenzen mit neutraler Moderation, schriftliche Delphi-Abstimmung) verabschiedet. Empfehlungen: Der Teil 1 dieser Kurzversion der Leitlinie zeigt Statements und Empfehlungen zur Epidemiologie, Ätiologie, der Prädiktion sowie der primären und sekundären Prävention der Frühgeburt.

Published
2023
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19. Update Breast Cancer 2023 Part 3 – Expert Opinions of Early Stage Breast Cancer Therapies

Author

Kolberg, Hans-Christian, additional, Hartkopf, Andreas D., additional, Fehm, Tanja N., additional, Welslau, Manfred, additional, Müller, Volkmar, additional, Schütz, Florian, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Witzel, Isabell, additional, Thomssen, Christoph, additional, Beierlein, Milena, additional, Belleville, Erik, additional, Untch, Michael, additional, Thill, Marc, additional, Tesch, Hans, additional, Ditsch, Nina, additional, Lux, Michael P., additional, Aktas, Bahriye, additional, Banys-Paluchowski, Maggie, additional, Kolberg-Liedtke, Cornelia, additional, Wöckel, Achim, additional, Harbeck, Nadia, additional, Stickeler, Elmar, additional, Bartsch, Rupert, additional, Schneeweiss, Andreas, additional, Ettl, Johannes, additional, Krug, David, additional, Taran, Florin-Andrei, additional, Lüftner, Diana, additional, and Würstlein, Rachel, additional

Published
2023
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20. Correction: Prevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/025, September 2022) – Part 2 with Recommendations on the Tertiary Prevention of Preterm Birth and on the Management of Preterm Premature Rupture of Membranes

Author

Berger, Richard, additional, Abele, Harald, additional, Bahlmann, Franz, additional, Doubek, Klaus, additional, Felderhoff-Müser, Ursula, additional, Fluhr, Herbert, additional, Garnier, Yves, additional, Grylka-Baeschlin, Susanne, additional, Hayward, Aurelia, additional, Helmer, Hanns, additional, Herting, Egbert, additional, Hoopmann, Markus, additional, Hösli, Irene, additional, Hoyme, Udo, additional, Kunze, Mirjam, additional, Kuon, Ruben-J., additional, Kyvernitakis, Ioannis, additional, Lütje, Wolf, additional, Mader, Silke, additional, Maul, Holger, additional, Mendling, Werner, additional, Mitschdörfer, Barbara, additional, Nothacker, Monika, additional, Olbertz, Dirk, additional, Ramsell, Andrea, additional, Rath, Werner, additional, Roll, Claudia, additional, Schlembach, Dietmar, additional, Schleußner, Ekkehard, additional, Schütz, Florian, additional, Seifert-Klauss, Vanadin, additional, Stubert, Johannes, additional, and Surbek, Daniel, additional

Published
2023
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21. Correction: Prevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry Number 015/025, September 2022) – Part 1 with Recommendations on the Epidemiology, Etiology, Prediction, Primary and Secondary Prevention of Preterm Birth

Author

Berger, Richard, additional, Abele, Harald, additional, Bahlmann, Franz, additional, Doubek, Klaus, additional, Felderhoff-Müser, Ursula, additional, Fluhr, Herbert, additional, Garnier, Yves, additional, Grylka-Baeschlin, Susanne, additional, Hayward, Aurelia, additional, Helmer, Hanns, additional, Herting, Egbert, additional, Hoopmann, Markus, additional, Hösli, Irene, additional, Hoyme, Udo, additional, Kunze, Mirjam, additional, Kuon, Ruben-J., additional, Kyvernitakis, Ioannis, additional, Lütje, Wolf, additional, Mader, Silke, additional, Maul, Holger, additional, Mendling, Werner, additional, Mitschdörfer, Barbara, additional, Nothacker, Monika, additional, Olbertz, Dirk, additional, Ramsell, Andrea, additional, Rath, Werner, additional, Roll, Claudia, additional, Schlembach, Dietmar, additional, Schleußner, Ekkehard, additional, Schütz, Florian, additional, Seifert-Klauss, Vanadin, additional, Stubert, Johannes, additional, and Surbek, Daniel, additional

Published
2023
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22. Update Breast Cancer 2023 Part 1 – Early Stage Breast Cancer

Author

Hartkopf, Andreas D., additional, Fehm, Tanja N., additional, Welslau, Manfred, additional, Müller, Volkmar, additional, Schütz, Florian, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Witzel, Isabell, additional, Thomssen, Christoph, additional, Beierlein, Milena, additional, Belleville, Erik, additional, Untch, Michael, additional, Thill, Marc, additional, Tesch, Hans, additional, Ditsch, Nina, additional, Lux, Michael P., additional, Aktas, Bahriye, additional, Banys-Paluchowski, Maggie, additional, Kolberg-Liedtke, Cornelia, additional, Wöckel, Achim, additional, Kolberg, Hans-Christian, additional, Harbeck, Nadia, additional, Stickeler, Elmar, additional, Bartsch, Rupert, additional, Schneeweiss, Andreas, additional, Ettl, Johannes, additional, Würstlein, Rachel, additional, Krug, David, additional, Taran, Florin-Andrei, additional, and Lüftner, Diana, additional

Published
2023
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23. Update Breast Cancer 2023 Part 2 – Advanced-Stage Breast Cancer

Author

Lux, Michael P., additional, Hartkopf, Andreas D., additional, Fehm, Tanja N., additional, Welslau, Manfred, additional, Müller, Volkmar, additional, Schütz, Florian, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Witzel, Isabell, additional, Thomssen, Christoph, additional, Beierlein, Milena, additional, Belleville, Erik, additional, Untch, Michael, additional, Thill, Marc, additional, Tesch, Hans, additional, Ditsch, Nina, additional, Aktas, Bahriye, additional, Banys-Paluchowski, Maggie, additional, Kolberg-Liedtke, Cornelia, additional, Wöckel, Achim, additional, Kolberg, Hans-Christian, additional, Harbeck, Nadia, additional, Bartsch, Rupert, additional, Schneeweiss, Andreas, additional, Ettl, Johannes, additional, Würstlein, Rachel, additional, Krug, David, additional, Taran, Florin-Andrei, additional, Lüftner, Diana, additional, and Stickeler, Elmar, additional

Published
2023
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24. Prevention and therapy of preterm birth : guideline of the DGGG, OEGGG and SGGG (S2k level, AWMF registry number 015/025, September 2022) - part 2 with recommendations on the tertiary prevention of preterm birth and on the management of preterm premature rupture of membranes

Author

Berger, Richard, Abele, Harald, Bahlmann, Franz, Doubek, Klaus, Felderhoff-Müser, Ursula, Fluhr, Herbert, Garnier, Yves, Grylka, Susanne, Hayward, Aurelia, Helmer, Hanns, Herting, Egbert, Hoopmann, Markus, Hösli, Irene, Hoyme, Udo, Kunze, Mirjam, Kuon, Ruben-H., Kyvernitakis, Ioannis, Lütje, Wolf, Mader, Silke, Maul, Holger, Mendling, Werner, Mitschdörfer, Barbara, Nothacker, Monika, Olbertz, Dirk, Ramsell, Andrea, Rath, Werner, Roll, Claudia, Schlembach, Dietmar, Schleußner, Ekkehard, Schütz, Florian, Seifert-Klauss, Vanadin, Stubert, Johannes, Surbek, Daniel, Berger, Richard, Abele, Harald, Bahlmann, Franz, Doubek, Klaus, Felderhoff-Müser, Ursula, Fluhr, Herbert, Garnier, Yves, Grylka, Susanne, Hayward, Aurelia, Helmer, Hanns, Herting, Egbert, Hoopmann, Markus, Hösli, Irene, Hoyme, Udo, Kunze, Mirjam, Kuon, Ruben-H., Kyvernitakis, Ioannis, Lütje, Wolf, Mader, Silke, Maul, Holger, Mendling, Werner, Mitschdörfer, Barbara, Nothacker, Monika, Olbertz, Dirk, Ramsell, Andrea, Rath, Werner, Roll, Claudia, Schlembach, Dietmar, Schleußner, Ekkehard, Schütz, Florian, Seifert-Klauss, Vanadin, Stubert, Johannes, and Surbek, Daniel

Abstract

Artikel in mehreren Sprachen: Englisch und Deutsch, Aim: The revision of this guideline was coordinated by the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (OEGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The aim of the guideline is to improve the prediction, prevention and management of preterm birth based on evidence from the current literature, the experience of members of the guidelines commission, and the viewpoint of self-help organizations. Methods: The members of the contributing professional societies and organizations developed recommendations and statements based on international literature. The recommendations and statements were presented and adopted using a formal process (structured consensus conferences with neutral moderation, written Delphi vote). Recommendations Part 2 of this short version of the guideline presents statements and recommendations on the tertiary prevention of preterm birth and the management of preterm premature rupture of membranes. Ziel: Überarbeitete Leitlinie der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG), der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) und der Schweizerischen Gesellschaft für Gynäkologie und Geburtshilfe (SGGG). Ziel der Leitlinie ist es, die Prädiktion, die Prävention und das Management der Frühgeburt anhand der aktuellen Literatur, der Erfahrung der Mitglieder der Leitlinienkommission einschließlich der Sicht der Selbsthilfe evidenzbasiert zu verbessern. Methoden: Anhand der internationalen Literatur entwickelten die Mitglieder der beteiligten Fachgesellschaften und Organisationen zahlreiche Empfehlungen und Statements. Diese wurden in einem formalen Prozess (strukturierte Konsensuskonferenzen mit neutraler Moderation, schriftliche Delphi-Abstimmung) verabschiedet. Empfehlungen: Der Teil 2 dieser Kurzversion der Leitlinie zeigt Statements und Empfehlungen zur tertiären Prävention der Frühgeburt sowie zum Management des frühen vorzeitig

Published
2023

25. Prevention and therapy of preterm birth : guideline of the DGGG, OEGGG and SGGG (S2k-level, AWMF registry number 015/025, September 2022) - part 1 with recommendations on the epidemiology, etiology, prediction, primary and secondary prevention of preterm birth

Author

Berger, Richard, Abele, Harald, Bahlmann, Franz, Doubek, Klaus, Felderhoff-Müser, Ursula, Fluhr, Herbert, Garnier, Yves, Grylka, Susanne, Hayward, Aurelia, Helmer, Hanns, Herting, Egbert, Hoopmann, Markus, Hösli, Irene, Hoyme, Udo, Kunze, Mirjam, Kuon, Ruben-H., Kyvernitakis, Ioannis, Lütje, Wolf, Mader, Silke, Maul, Holger, Mendling, Werner, Mitschdörfer, Barbara, Nothacker, Monika, Olbertz, Dirk, Ramsell, Andrea, Rath, Werner, Roll, Claudia, Schlembach, Dietmar, Schleußner, Ekkehard, Schütz, Florian, Seifert-Klauss, Vanadin, Stubert, Johannes, Surbek, Daniel, Berger, Richard, Abele, Harald, Bahlmann, Franz, Doubek, Klaus, Felderhoff-Müser, Ursula, Fluhr, Herbert, Garnier, Yves, Grylka, Susanne, Hayward, Aurelia, Helmer, Hanns, Herting, Egbert, Hoopmann, Markus, Hösli, Irene, Hoyme, Udo, Kunze, Mirjam, Kuon, Ruben-H., Kyvernitakis, Ioannis, Lütje, Wolf, Mader, Silke, Maul, Holger, Mendling, Werner, Mitschdörfer, Barbara, Nothacker, Monika, Olbertz, Dirk, Ramsell, Andrea, Rath, Werner, Roll, Claudia, Schlembach, Dietmar, Schleußner, Ekkehard, Schütz, Florian, Seifert-Klauss, Vanadin, Stubert, Johannes, and Surbek, Daniel

Abstract

Artikel in mehreren Sprachen: Deutsch und Englisch, Aim: This revised guideline was coordinated by the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (OEGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). It aims to improve the prediction, prevention, and management of preterm birth, based on evidence from the current literature, the experience of members of the guidelines commission, and the viewpoint of self-help organizations. Methods: The members of the contributing professional societies and organizations developed recommendations and statements based on international literature. The recommendations and statements were presented and adopted using a formal process (structured consensus conferences with neutral moderation, written Delphi vote). Recommendations: Part 1 of this short version of the guideline presents statements and recommendations on the epidemiology, etiology, prediction, and primary and secondary prevention of preterm birth. Ziel: Überarbeitete Leitlinie der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG), der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) und der Schweizerischen Gesellschaft für Gynäkologie und Geburtshilfe (SGGG). Ziel der Leitlinie ist es, die Prädiktion, die Prävention und das Management der Frühgeburt anhand der aktuellen Literatur, der Erfahrung der Mitglieder der Leitlinienkommission einschließlich der Sicht der Selbsthilfe evidenzbasiert zu verbessern. Methoden: Anhand der internationalen Literatur entwickelten die Mitglieder der beteiligten Fachgesellschaften und Organisationen zahlreiche Empfehlungen und Statements. Diese wurden in einem formalen Prozess (strukturierte Konsensuskonferenzen mit neutraler Moderation, schriftliche Delphi-Abstimmung) verabschiedet. Empfehlungen: Der Teil 1 dieser Kurzversion der Leitlinie zeigt Statements und Empfehlungen zur Epidemiologie, Ätiologie, der Prädiktion sowie der primären und sekundären Prävention der Frühgeburt.

Published
2023

26. Update Breast Cancer 2023 Part 1 – Early Stage Breast Cancer

Author

Hartkopf, Andreas D, Fehm, Tanja N, Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A, Janni, Wolfgang, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Stickeler, Elmar, Bartsch, Rupert, Schneeweiss, Andreas, Ettl, Johannes, Würstlein, Rachel, Krug, David; https://orcid.org/0000-0001-8811-5416, Taran, Florin-Andrei, Lüftner, Diana, Hartkopf, Andreas D, Fehm, Tanja N, Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A, Janni, Wolfgang, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Stickeler, Elmar, Bartsch, Rupert, Schneeweiss, Andreas, Ettl, Johannes, Würstlein, Rachel, Krug, David; https://orcid.org/0000-0001-8811-5416, Taran, Florin-Andrei, and Lüftner, Diana

Abstract

With abemaciclib (monarchE study) and olaparib (OlympiA study) gaining approval in the adjuvant treatment setting, a significant change in the standard of care for patients with early stage breast cancer has been established for some time now. Accordingly, some diverse developments are slowly being transferred from the metastatic to the adjuvant treatment setting. Recently, there have also been positive reports of the NATALEE study.Other clinical studies are currently investigating substances that are already established in the metastatic setting. These include, for example, the DESTINY Breast05 study with trastuzumab deruxtecan and the SASCIA study with sacituzumab govitecan.In this review paper, we summarize and place in context the latest developments over the past months.

Published
2023

27. Update Breast Cancer 2022 Part 6 – Advanced-Stage Breast Cancer

Author

Lüftner, Diana, Lux, Michael P, Fehm, Tanja N, Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A, Janni, Wolfgang, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Ditsch, Nina, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Stickeler, Elmar, Tesch, Hans, Hartkopf, Andreas D, Lüftner, Diana, Lux, Michael P, Fehm, Tanja N, Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A, Janni, Wolfgang, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Ditsch, Nina, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Stickeler, Elmar, Tesch, Hans, and Hartkopf, Andreas D

Abstract

Large-scale study programs on CDK4/6 inhibitors, targeted therapies, and antibody–drug conjugates launched in recent years have yielded results from current studies which are now being published in journals and presented at international conferences. In this context, new results are available from the major CDK4/6 inhibitor studies. Also, an increasing amount of data is being published from large-scale genomic studies on efficacy and resistance mechanisms in patients treated with CDK4/6 inhibitors. These results now form the basis for further research plans to investigate combination therapies and treatment sequencing. Based on the latest published results, sacituzumab govitecan is now available as a second antibody–drug conjugate; this brings an advantage in terms of overall survival for patients with hormone receptor-positive (HRpos)/HER2-negative (HER2neg) breast cancer. In this review article, we summarize the latest developments and place them in context according to the current status of research.

Published
2023

28. Update Breast Cancer 2022 Part 5 – Early Stage Breast Cancer

Author

Fehm, Tanja N, Welslau, Manfred, Müller, Volkmar, Lüftner, Diana, Schütz, Florian, Fasching, Peter A, Janni, Wolfgang, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Hartkopf, Andreas D, Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Stickeler, Elmar, Fehm, Tanja N, Welslau, Manfred, Müller, Volkmar, Lüftner, Diana, Schütz, Florian, Fasching, Peter A, Janni, Wolfgang, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Hartkopf, Andreas D, Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, and Stickeler, Elmar

Abstract

The treatment of patients with early stage breast cancer has changed in recent years due to the introduction of pembrolizumab, olaparib, and abemaciclib. These and other drugs with the same class of active ingredient are currently in trial for various indications. This review article summarizes the latest results that have either been presented at major conferences such as the ESMO 2022 or published recently in international journals. This includes reports on newly discovered breast cancer genes, atezolizumab in neoadjuvant therapy in HER2-positive patients, long-term data from the APHINITY study, and on how preoperative peritumoral application of local anesthetics can influence the prognosis. We also present solid data on dynamic Ki-67 from the ADAPT studies.

Published
2023

29. Update Breast Cancer 2023 Part 2 – Advanced-Stage Breast Cancer

Author

Lux, Michael P, Hartkopf, Andreas D, Fehm, Tanja N, Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A, Janni, Wolfgang, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Bartsch, Rupert, Schneeweiss, Andreas, Ettl, Johannes, Würstlein, Rachel, Krug, David; https://orcid.org/0000-0001-8811-5416, Taran, Florin-Andrei, Lüftner, Diana, Stickeler, Elmar, Lux, Michael P, Hartkopf, Andreas D, Fehm, Tanja N, Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A, Janni, Wolfgang, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Bartsch, Rupert, Schneeweiss, Andreas, Ettl, Johannes, Würstlein, Rachel, Krug, David; https://orcid.org/0000-0001-8811-5416, Taran, Florin-Andrei, Lüftner, Diana, and Stickeler, Elmar

Abstract

In recent years, a number of new therapies have led to advances in the treatment of patients with advanced breast carcinoma. These substances are mainly CDK4/6 inhibitors and other substances that can overcome endocrine resistance, oral selective estrogen receptor degraders, antibody drug conjugates (ADCs), and PARP inhibitors. This review summarizes and evaluates the latest study results that have been published in recent months. This includes the overall survival data of the Destiny-Breast03 study, the first analysis of the CAPItello-291 study, the comparison of CDK4/6 inhibitor treatment with chemotherapy in the first line of therapy (RIGHT Choice study), the first analysis of the Destiny-Breast02 study in the treatment setting after T-DM1 treatment, and the first analysis of the Serena-2 study.Most of these studies have the potential to significantly change the therapeutic landscape for patients with advanced breast carcinoma and show that the continued rapid development of new therapies is always producing new results.

Published
2023

30. Update Breast Cancer 2023 Part 3 – Expert Opinions of Early Stage Breast Cancer Therapies

Author

Kolberg, Hans-Christian, Hartkopf, Andreas D, Fehm, Tanja N, Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A, Janni, Wolfgang, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc; https://orcid.org/0000-0002-8800-8044, Tesch, Hans, Ditsch, Nina, Lux, Michael P, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Wöckel, Achim, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Stickeler, Elmar, Bartsch, Rupert, Schneeweiss, Andreas, Ettl, Johannes, Krug, David; https://orcid.org/0000-0001-8811-5416, Taran, Florin-Andrei, Lüftner, Diana, Würstlein, Rachel, Kolberg, Hans-Christian, Hartkopf, Andreas D, Fehm, Tanja N, Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A, Janni, Wolfgang, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc; https://orcid.org/0000-0002-8800-8044, Tesch, Hans, Ditsch, Nina, Lux, Michael P, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Wöckel, Achim, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Stickeler, Elmar, Bartsch, Rupert, Schneeweiss, Andreas, Ettl, Johannes, Krug, David; https://orcid.org/0000-0001-8811-5416, Taran, Florin-Andrei, Lüftner, Diana, and Würstlein, Rachel

Abstract

The St. Gallen (SG) International Breast Cancer Conference is held every two years, previously in St. Gallen and now in Vienna. This year (2023) marks the eighteenth edition of this conference, which focuses on the treatment of patients with early-stage breast carcinoma. A panel discussion will be held at the end of this four-day event, during which a panel of experts will give their opinions on current controversial issues relating to the treatment of early-stage breast cancer patients. To this end, questions are generally formulated in such a way that clinically realistic cases are presented – often including poignant hypothetical modifications. This review reports on the outcome of these discussions and summarises the data associated with individual questions raised.

Published
2023

31. Prevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry Number 015/025, September 2022) – Part 1 with Recommendations on the Epidemiology, Etiology, Prediction, Primary and Secondary Prevention of Preterm Birth

Author

Berger, Richard, additional, Abele, Harald, additional, Bahlmann, Franz, additional, Doubek, Klaus, additional, Felderhoff-Müser, Ursula, additional, Fluhr, Herbert, additional, Garnier, Yves, additional, Grylka-Baeschlin, Susanne, additional, Hayward, Aurelia, additional, Helmer, Hanns, additional, Herting, Egbert, additional, Hoopmann, Markus, additional, Hösli, Irene, additional, Hoyme, Udo, additional, Kunze, Mirjam, additional, Kuon, Ruben-H., additional, Kyvernitakis, Ioannis, additional, Lütje, Wolf, additional, Mader, Silke, additional, Maul, Holger, additional, Mendling, Werner, additional, Mitschdörfer, Barbara, additional, Nothacker, Monika, additional, Olbertz, Dirk, additional, Ramsell, Andrea, additional, Rath, Werner, additional, Roll, Claudia, additional, Schlembach, Dietmar, additional, Schleußner, Ekkehard, additional, Schütz, Florian, additional, Seifert-Klauss, Vanadin, additional, Stubert, Johannes, additional, and Surbek, Daniel, additional

Published
2023
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32. Prevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/025, September 2022) – Part 2 with Recommendations on the Tertiary Prevention of Preterm Birth and on the Management of Preterm Premature Rupture of Membranes

Author

Berger, Richard, additional, Abele, Harald, additional, Bahlmann, Franz, additional, Doubek, Klaus, additional, Felderhoff-Müser, Ursula, additional, Fluhr, Herbert, additional, Garnier, Yves, additional, Grylka-Baeschlin, Susanne, additional, Hayward, Aurelia, additional, Helmer, Hanns, additional, Herting, Egbert, additional, Hoopmann, Markus, additional, Hösli, Irene, additional, Hoyme, Udo, additional, Kunze, Mirjam, additional, Kuon, Ruben-H., additional, Kyvernitakis, Ioannis, additional, Lütje, Wolf, additional, Mader, Silke, additional, Maul, Holger, additional, Mendling, Werner, additional, Mitschdörfer, Barbara, additional, Nothacker, Monika, additional, Olbertz, Dirk, additional, Ramsell, Andrea, additional, Rath, Werner, additional, Roll, Claudia, additional, Schlembach, Dietmar, additional, Schleußner, Ekkehard, additional, Schütz, Florian, additional, Seifert-Klauss, Vanadin, additional, Stubert, Johannes, additional, and Surbek, Daniel, additional

Published
2023
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33. Abstract P2-14-01: MOLECULAR FLUORESCENCE-GUIDED SURGERY USING BEVA800 FOR THE ASSESSMENT OF TUMOR MARGINS DURING BREAST CONSERVING SURGERY OF PATIENTS WITH PRIMARY BREAST CANCER (MARGIN-II)

Author

Kolberg, Hans-Christian, primary, Röhm, Carmen, additional, Stachs, Angrit, additional, Schütz, Florian, additional, Blohmer, Jens-Uwe, additional, Wetzig, Sarah, additional, Hartmann, Steffi, additional, Heil, Jörg, additional, and Hahn, Markus, additional

Published
2023
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34. Update Breast Cancer 2022 Part 5 – Early Stage Breast Cancer

Author

Fehm, Tanja N., additional, Welslau, Manfred, additional, Müller, Volkmar, additional, Lüftner, Diana, additional, Schütz, Florian, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Thomssen, Christoph, additional, Witzel, Isabell, additional, Beierlein, Milena, additional, Belleville, Erik, additional, Untch, Michael, additional, Thill, Marc, additional, Tesch, Hans, additional, Ditsch, Nina, additional, Lux, Michael P., additional, Aktas, Bahriye, additional, Banys-Paluchowski, Maggie, additional, Kolberg-Liedtke, Cornelia, additional, Hartkopf, Andreas D., additional, Wöckel, Achim, additional, Kolberg, Hans-Christian, additional, Harbeck, Nadia, additional, and Stickeler, Elmar, additional

Published
2023
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35. Update Breast Cancer 2022 Part 6 – Advanced-Stage Breast Cancer

Author

Lüftner, Diana, additional, Lux, Michael P., additional, Fehm, Tanja N., additional, Welslau, Manfred, additional, Müller, Volkmar, additional, Schütz, Florian, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Thomssen, Christoph, additional, Witzel, Isabell, additional, Beierlein, Milena, additional, Belleville, Erik, additional, Untch, Michael, additional, Thill, Marc, additional, Ditsch, Nina, additional, Aktas, Bahriye, additional, Banys-Paluchowski, Maggie, additional, Kolberg-Liedtke, Cornelia, additional, Wöckel, Achim, additional, Kolberg, Hans-Christian, additional, Harbeck, Nadia, additional, Stickeler, Elmar, additional, Tesch, Hans, additional, and Hartkopf, Andreas D., additional

Published
2023
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36. Update Breast Cancer 2021 Part 3 - Current Developments in the Treatment of Early Breast Cancer : Review and Assessment of Specialised Treatment Scenarios by an International Expert Panel

Author

Fehm, Tanja N., Stickeler, Elmar, Fasching, Peter A., Janni, Wolfgang, Kolberg-Liedtke, Cornelia, Kolberg, Hans-Christian, Lüftner, Diana, Müller, Volkmar, Schütz, Florian, Thomssen, Christoph, Belleville, Erik, Behrens, Annika, Bader, Simon, Untch, Michael, Welslau, Manfred, Würstlein, Rachel, Thill, Marc, Krug, David, and Hartkopf, Andreas D.

Subjects
Medizin
Abstract

ZusammenfassungKontinuierlich neue Studienergebnisse führen wiederholt zu aktualisierten Therapieempfehlungen und Leitlinien. Insbesondere beim Mammakarzinom wurden in den letzten Jahren einige Studien veröffentlicht, welche die Behandlung des frühen und fortgeschrittenen Mammakarzinoms deutlich verändert haben. Dies bedeutet jedoch nicht, dass die Meinungen aller Experten bei speziellen Fragen übereinstimmen. Gerade die Diversität bezüglich der Interpretation der Leitlinien und Studienergebnisse reflektiert die sich ständig ändernde Datenlage und ihre Komplexität sowie die Verfügbarkeit von neuen Medikamenten. Für die Therapie von Patientinnen mit frühen Stadien des Mammakarzinoms sind in den letzten Jahren neue Substanzen wie Pertuzumab, T‑DM1, Neratinib, Capecitabin und weitere hinzugekommen. Des Weiteren gibt es erste Ergebnisse zum Einsatz von CDK4/6-Inhibitoren in der adjuvanten Situation. Nicht zuletzt wird nach wie vor diskutiert, wie Multigentests eingesetzt werden können, um den Einsatz von Chemotherapien bei bestimmten Patientinnen vermeiden zu können. Diese Übersichtsarbeit fasst den Datenstand zusammen und veröffentlich die Abstimmungsergebnisse der St.‑Gallen-Brustkrebskonferenz 2021 zum Mammakarzinom in frühen Krankheitsstadien.

Published
2022
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38. Gynecologic oncologists’ attitudes and practices relating to integrative medicine: results of a nationwide AGO survey

Author

Klein, Evelyn, Beckmann, Matthias W., Bader, Werner, Brucker, Cosima, Dobos, Gustav, Fischer, Dorothea, Hanf, Volker, Hasenburg, Annette, Jud, Sebastian M., Kalder, Matthias, Kiechle, Marion, Kümmel, Sherko, Müller, Andreas, Müller, Myrjam-Alice T., Paepke, Daniela, Rotmann, Andre-Robert, Schütz, Florian, Scharl, Anton, Voiss, Petra, Wallwiener, Markus, Witt, Claudia, and Hack, Carolin C.

Published
2017
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39. Update Mammakarzinom 2022 Teil 6 : Brustkrebs in fortgeschrittenen Krankheitsstadien

Author

Lüftner, Diana, Lux, Michael P., Fehm, Tanja N., Welslau, Manfred, Müller, Volkmar, Schütz, Florian, Fasching, Peter A., Janni, Wolfgang, Thomssen, Christoph, Witzel, Isabell, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Ditsch, Nina, Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia, Stickeler, Elmar, Tesch, Hans, and Hartkopf, Andreas D.

Subjects
Medizin
Abstract

Large-scale study programs on CDK4/6 inhibitors, targeted therapies, and antibody-drug conjugates launched in recent years have yielded results from current studies which are now being published in journals and presented at international conferences. In this context, new results are available from the major CDK4/6 inhibitor studies. Also, an increasing amount of data is being published from large-scale genomic studies on efficacy and resistance mechanisms in patients treated with CDK4/6 inhibitors. These results now form the basis for further research plans to investigate combination therapies and treatment sequencing. Based on the latest published results, sacituzumab govitecan is now available as a second antibody-drug conjugate; this brings an advantage in terms of overall survival for patients with hormone receptor-positive (HRpos)/HER2-negative (HER2neg) breast cancer. In this review article, we summarize the latest developments and place them in context according to the current status of research.

Published
2023

40. Update Mammakarzinom 2022 Teil 5 : Brustkrebs in frühen Krankheitsstadien

Author

Fehm, Tanja N., Welslau, Manfred, Müller, Volkmar, Lüftner, Diana, Schütz, Florian, Fasching, Peter A., Janni, Wolfgang, Thomssen, Christoph, Witzel, Isabell, Beierlein, Milena, Belleville, Erik, Untch, Michael, Thill, Marc, Tesch, Hans, Ditsch, Nina, Lux, Michael P., Aktas, Bahriye, Banys-Paluchowski, Maggie, Kolberg-Liedtke, Cornelia, Hartkopf, Andreas D., Wöckel, Achim, Kolberg, Hans-Christian, Harbeck, Nadia, and Stickeler, Elmar

Subjects
Medizin
Abstract

The treatment of patients with early stage breast cancer has changed in recent years due to the introduction of pembrolizumab, olaparib, and abemaciclib. These and other drugs with the same class of active ingredient are currently in trial for various indications. This review article summarizes the latest results that have either been presented at major conferences such as the ESMO 2022 or published recently in international journals. This includes reports on newly discovered breast cancer genes, atezolizumab in neoadjuvant therapy in HER2-positive patients, long-term data from the APHINITY study, and on how preoperative peritumoral application of local anesthetics can influence the prognosis. We also present solid data on dynamic Ki-67 from the ADAPT studies.

Published
2023

41. Arbeitsgemeinschaft Gynäkologische Onkologie Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2023

Author

Park-Simon, Tjoung-Won, primary, Müller, Volkmar, additional, Jackisch, Christian, additional, Albert, Ute-Susann, additional, Banys-Paluchowski, Maggie, additional, Bauerfeind, Ingo, additional, Blohmer, Jens-Uwe, additional, Budach, Wilfried, additional, Dall, Peter, additional, Ditsch, Nina, additional, Fallenberg, Eva Maria, additional, Fasching, Peter A., additional, Fehm, Tanja, additional, Friedrich, Michael, additional, Gerber, Bernd, additional, Gluz, Oleg, additional, Harbeck, Nadia, additional, Hartkopf, Andreas D., additional, Heil, Joerg, additional, Huober, Jens, additional, Kolberg-Liedtke, Cornelia, additional, Kreipe, Hans H., additional, Krug, David, additional, Kühn, Thorsten, additional, Kümmel, Sherko, additional, Loibl, Sibylle, additional, Lüftner, Diana, additional, Lux, Michael Patrick, additional, Maass, Nicolai, additional, Mundhenke, Christoph, additional, Reimer, Toralf, additional, Rhiem, Kerstin, additional, Rody, Achim, additional, Schmidt, Marcus, additional, Schneeweiss, Andreas, additional, Schütz, Florian, additional, Sinn, Hans Peter, additional, Solbach, Christine, additional, Solomayer, Erich-Franz, additional, Stickeler, Elmar, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Witzel, Isabell, additional, Wöckel, Achim, additional, Wuerstlein, Rachel, additional, Janni, Wolfgang, additional, and Thill, Marc, additional

Published
2023
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43. AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2023

Author

Thill, Marc, primary, Kolberg-Liedtke, Cornelia, additional, Albert, Ute-Susann, additional, Banys-Paluchowski, Maggie, additional, Bauerfeind, Ingo, additional, Blohmer, Jens-Uwe, additional, Budach, Wilfried, additional, Dall, Peter, additional, Ditsch, Nina, additional, Fallenberg, Eva Maria, additional, Fasching, Peter A., additional, Fehm, Tanja, additional, Friedrich, Michael, additional, Gerber, Bernd, additional, Gluz, Oleg, additional, Harbeck, Nadia, additional, Hartkopf, Andreas D., additional, Heil, Joerg, additional, Huober, Jens, additional, Jackisch, Christian, additional, Kreipe, Hans H., additional, Krug, David, additional, Kühn, Thorsten, additional, Kümmel, Sherko, additional, Loibl, Sibylle, additional, Lüftner, Diana, additional, Lux, Michael Patrick, additional, Maass, Nicolai, additional, Mundhenke, Christoph, additional, Reimer, Toralf, additional, Rhiem, Kerstin, additional, Rody, Achim, additional, Schmidt, Marcus, additional, Schneeweiss, Andreas, additional, Schütz, Florian, additional, Sinn, Hans Peter, additional, Solbach, Christine, additional, Solomayer, Erich-Franz, additional, Stickeler, Elmar, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Witzel, Isabell, additional, Wöckel, Achim, additional, Wuerstlein, Rachel, additional, Müller, Volkmar, additional, Janni, Wolfgang, additional, and Park-Simon, Tjoung-Won, additional

Published
2023
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44. CDK4/6 Inhibitors in Advanced HR+/HER2 – Breast Cancer: A Multicenter Real-World Data Analysis

Author

Müller, Carolin, primary, Kiver, Verena, additional, Solomayer, Erich-Franz, additional, Wagenpfeil, Gudrun, additional, Neeb, Caroline, additional, Blohmer, Jens-Uwe, additional, Abramian, Alina Valik, additional, Maass, Nicolai, additional, Schütz, Florian, additional, Kolberg-Liedtke, Cornelia, additional, Ralser, Damian Johannes, additional, and Rambow, Anna-Christina, additional

Published
2022
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47. AGO Recommendations for the Surgical Therapy of Breast Cancer: Update 2022

Author

Banys-Paluchowski, Maggie, additional, Thill, Marc, additional, Kühn, Thorsten, additional, Ditsch, Nina, additional, Heil, Jörg, additional, Wöckel, Achim, additional, Fallenberg, Eva, additional, Friedrich, Michael, additional, Kümmel, Sherko, additional, Müller, Volkmar, additional, Janni, Wolfgang, additional, Albert, Ute-Susann, additional, Bauerfeind, Ingo, additional, Blohmer, Jens-Uwe, additional, Budach, Wilfried, additional, Dall, Peter, additional, Fasching, Peter, additional, Fehm, Tanja, additional, Gluz, Oleg, additional, Harbeck, Nadia, additional, Huober, Jens, additional, Jackisch, Christian, additional, Kolberg-Liedtke, Cornelia, additional, Kreipe, Hans H., additional, Krug, David, additional, Loibl, Sibylle, additional, Lüftner, Diana, additional, Lux, Michael Patrick, additional, Maass, Nicolai, additional, Mundhenke, Christoph, additional, Nitz, Ulrike, additional, Park-Simon, Tjoung Won, additional, Reimer, Toralf, additional, Rhiem, Kerstin, additional, Rody, Achim, additional, Schmidt, Marcus, additional, Schneeweiss, Andreas, additional, Schütz, Florian, additional, Sinn, H. Peter, additional, Solbach, Christine, additional, Solomayer, Erich-Franz, additional, Stickeler, Elmar, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Witzel, Isabell, additional, and Gerber, Bernd, additional

Published
2022
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48. Update Breast Cancer 2022 Part 4 – Advanced-Stage Breast Cancer

Author

Aktas, Bahriye, additional, Fehm, Tanja N., additional, Welslau, Manfred, additional, Müller, Volkmar, additional, Lüftner, Diana, additional, Schütz, Florian, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Thomssen, Christoph, additional, Witzel, Isabell, additional, Belleville, Erik, additional, Untch, Michael, additional, Thill, Marc, additional, Tesch, Hans, additional, Ditsch, Nina, additional, Lux, Michael P., additional, Banys-Paluchowski, Maggie, additional, Kolberg-Liedtke, Cornelia, additional, Hartkopf, Andreas D., additional, Wöckel, Achim, additional, Kolberg, Hans-Christian, additional, Stickeler, Elmar, additional, Harbeck, Nadia, additional, and Schneeweiss, Andreas, additional

Published
2022
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49. Update Breast Cancer 2022 Part 3 – Early-Stage Breast Cancer

Author

Fehm, Tanja N., additional, Welslau, Manfred, additional, Müller, Volkmar, additional, Lüftner, Diana, additional, Schütz, Florian, additional, Fasching, Peter A., additional, Janni, Wolfgang, additional, Thomssen, Christoph, additional, Witzel, Isabell, additional, Belleville, Erik, additional, Untch, Michael, additional, Thill, Marc, additional, Tesch, Hans, additional, Ditsch, Nina, additional, Lux, Michael P., additional, Aktas, Bahriye, additional, Banys-Paluchowski, Maggie, additional, Schneeweiss, Andreas, additional, Kolberg-Liedtke, Cornelia, additional, Hartkopf, Andreas D., additional, Wöckel, Achim, additional, Kolberg, Hans-Christian, additional, Harbeck, Nadia, additional, and Stickeler, Elmar, additional

Published
2022
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