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1. A pragmatic, open-label, multi-center, randomized controlled clinical trial on the rotational use of interfaces vs standard of care in patients treated with noninvasive positive pressure ventilation for acute hypercapnic respiratory failure: the ROTAtional-USE of interface STUDY (ROTA-USE STUDY)

Author

Vaschetto, Rosanna, Gregoretti, Cesare, Scotti, Lorenza, De Vita, Nello, Carlucci, Annalisa, Cortegiani, Andrea, Crimi, Claudia, Mattei, Alessio, Scala, Raffaele, Rocca, Eduardo, Longhini, Federico, Cammarota, Gianmaria, Misseri, Giovanni, Dal Molin, Alberto, Scolletta, Sabino, Nava, Stefano, Maggiore, Salvatore Maurizio, and Navalesi, Paolo

Published
2023
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4. High-Intensity Exercise Training Impact on Cardiorespiratory Fitness, Gait Ability, and Balance in Stroke Survivors: A Systematic Review and Meta-Analysis.

Author

Baricich, Alessio, Borg, Margherita Beatrice, Battaglia, Marco, Facciorusso, Salvatore, Spina, Stefania, Invernizzi, Marco, Scotti, Lorenza, Cosenza, Lucia, Picelli, Alessandro, and Santamato, Andrea

Subjects
EXERCISE therapy, STROKE rehabilitation, CARDIOPULMONARY fitness, STROKE patients, PHYSICAL activity
Abstract

Stroke survivors commonly face challenges such as reduced physical activity and cardiorespiratory fitness (CRF) as well as balance and gait impairments, exacerbating their disability. While high-intensity exercise interventions have demonstrated some potential, their effects on these items remain uncertain. Therefore, our study aimed to investigate the impact of high-intensity training protocols on CRF, gait ability, and balance in stroke survivor populations. Two independent investigators systematically searched five databases for relevant RCTs following the PICO model. Through a systematic review of 25 RCTs published up to 31 May 2023, including adult first-stroke survivors, comparing high-intensity exercise training versus low-to-mild or no exercises, we evaluated outcomes such as the Six-Minute Walking Test (6 MWT), peak oxygen uptake (VO2peak), Ten-Meter Walk Test (10 MWT), Berg Balance Scale (BBS), and Timed Up and Go test (TUG). The protocol was registered in PROSPERO (registration number CRD42023456773). Meta-analyses indicated significant enhancements in CRF, as measured by 6 MWT and VO2peak, following high-intensity exercise interventions. However, no significant differences were observed in BBS, 10 MWT, and TUG. Our findings underscore the potential of high-intensity exercise interventions in ameliorating CRF among stroke survivors, although further research involving standardized protocols and long-term follow-ups is imperative to optimize rehabilitation outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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5. The Role of Diet in Multiple Sclerosis Onset: A Prospective Study Using UK Biobank.

Author

Barbero Mazzucca, Camilla, Scotti, Lorenza, Comi, Cristoforo, Vecchio, Domizia, Chiocchetti, Annalisa, and Cappellano, Giuseppe

Abstract

Multiple sclerosis (MS) is a debilitating autoimmune condition primarily affecting young adults, and its rise is evident globally. Despite this, its precise etiology remains elusive. Both genetic and environmental factors contribute to MS susceptibility; however, the link between diet and MS lacks substantial evidence due to limited large-scale studies. We exploited the UK Biobank resources to explore the nexus between diet, lifestyle, and MS risk. The dietary and lifestyle habits of MS incident cases, derived from a general food frequency questionnaire (FFQ) completed by all participants at study enrollment, were compared to those of subjects who did not develop MS during the follow-up. Our findings suggest the protective role of moderate oily fish consumption and weekly alcohol intake. Furthermore, by analyzing food intake data obtained through 24 h recall, completed by a subset of participants, we found a protective, though non-significant, trend of an increased adherence to the Mediterranean diet (MD). These findings, derived from the analysis of the UK Biobank and representing an unprecedented approach for this inquiry, warrant further exploration and integration in future research. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Design and Validation of MEDOC, a Tool to Assess the Combined Adherence to Mediterranean and Western Dietary Patterns.

Author

Mazzucca, Camilla Barbero, Scotti, Lorenza, Raineri, Davide, Cappellano, Giuseppe, and Chiocchetti, Annalisa

Abstract

The Mediterranean diet (MD) and Western diet (WD) are poles apart as dietary patterns. Despite the availability of epidemiological tools to estimate the adherence to MD, to date, there is a lack of combined scores. We developed MEDOC, a food frequency questionnaire (FFQ) designed to calculate a combined adherence score for both diets and validated it on 213 subjects. The test–retest reliability revealed all frequency questions falling within the acceptable range of 0.5 to 0.7 (Pearson correlation coefficient) in younger (<30 years old) subjects, while 1 question out of 39 fell below the range in older (>30 years old) participants. The reproducibility for portion size was less satisfying, with, respectively, 38.2% and 70.5% of questions falling below 0.5 (Cohen's Kappa index) for younger and older subjects. The good correlation (R = 0.63, p < 0.0001 for subjects younger than 30 years and R = 0.54, p < 0.0001 for subjects older than 30 years, Pearson's correlation coefficient) between the MEDOC score and the MediDietScore (MDS) confirmed the validity of the MEDOC score in identifying patients who adhere to the MD. Harnessing the capabilities of this innovative tool, we aim to broaden the existing perspective to study complex dietary patterns in nutritional epidemiology studies. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Shotgun Proteomics Links Proteoglycan-4 + Extracellular Vesicles to Cognitive Protection in Amyotrophic Lateral Sclerosis.

Author

Vilardo, Beatrice, De Marchi, Fabiola, Raineri, Davide, Manfredi, Marcello, De Giorgis, Veronica, Bebeti, Alen, Scotti, Lorenza, Kustrimovic, Natasa, Cappellano, Giuseppe, Mazzini, Letizia, and Chiocchetti, Annalisa

Subjects
EXTRACELLULAR vesicles, AMYOTROPHIC lateral sclerosis, MOTOR neuron diseases, PROTEOMICS, CEREBROSPINAL fluid, NEURODEGENERATION
Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder lacking reliable biomarkers for early diagnosis and disease progression monitoring. This study aimed to identify the novel biomarkers in plasmatic extracellular vesicles (EVs) isolated from ALS patients and healthy controls (HCs). A total of 61 ALS patients and 30 age-matched HCs were enrolled in the study and the protein content of circulating EVs was analyzed by shotgun proteomics. The study was divided into a discovery phase (involving 12 ALS and 12 HC patients) and a validation one (involving 49 ALS and 20 HC patients). In the discovery phase, more than 300 proteins were identified, with 32 proteins showing differential regulation in ALS patients compared to HCs. In the validation phase, over 400 proteins were identified, with 20 demonstrating differential regulation in ALS patients compared to HCs. Notably, seven proteins were found to be common to both phases, all of which were significantly upregulated in EVs from ALS patients. Most of them have previously been linked to ALS since they have been detected in the serum or cerebrospinal fluid of ALS patients. Among them, proteoglycan (PRG)-4, also known as lubricin, was of particular interest since it was significantly increased in ALS patients with normal cognitive and motor functions. This study highlights the significance of EVs as a promising avenue for biomarker discovery in ALS. Moreover, it sheds light on the unexpected role of PRG-4 in relation to cognitive status in ALS patients. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Author

Bellan, Mattia, Patti, Giuseppe, Hayden, Eyal, Azzolina, Danila, Pirisi, Mario, Acquaviva, Antonio, Aimaretti, Gianluca, Aluffi Valletti, Paolo, Angilletta, Roberto, Arioli, Roberto, Avanzi, Gian Carlo, Avino, Gianluca, Balbo, Piero Emilio, Baldon, Giulia, Baorda, Francesca, Barbero, Emanuela, Baricich, Alessio, Barini, Michela, Barone-Adesi, Francesco, Battistini, Sofia, Beltrame, Michela, Bertoli, Matteo, Bertolin, Stephanie, Bertolotti, Marinella, Betti, Marta, Bobbio, Flavio, Boffano, Paolo, Boglione, Lucio, Borrè, Silvio, Brucoli, Matteo, Calzaducca, Elisa, Cammarata, Edoardo, Cantaluppi, Vincenzo, Cantello, Roberto, Capponi, Andrea, Carriero, Alessandro, Casciaro, Francesco Giuseppe, Castello, Luigi Mario, Ceruti, Federico, Chichino, Guido, Chirico, Emilio, Cisari, Carlo, Cittone, Micol Giulia, Colombo, Crizia, Comi, Cristoforo, Croce, Eleonora, Daffara, Tommaso, Danna, Pietro, Della Corte, Francesco, De Vecchi, Simona, Dianzani, Umberto, Di Benedetto, Davide, Esposto, Elia, Faggiano, Fabrizio, Falaschi, Zeno, Ferrante, Daniela, Ferrero, Alice, Gagliardi, Ileana, Gaidano, Gianluca, Galbiati, Alessandra, Gallo, Silvia, Garavelli, Pietro Luigi, Gardino, Clara Ada, Garzaro, Massimiliano, Gastaldello, Maria Luisa, Gavelli, Francesco, Gennari, Alessandra, Giacomini, Greta Maria, Giacone, Irene, Giai Via, Valentina, Giolitti, Francesca, Gironi, Laura Cristina, Gramaglia, Carla, Grisafi, Leonardo, Inserra, Ilaria, Invernizzi, Marco, Krengli, Marco, Labella, Emanuela, Landi, Irene Cecilia, Landi, Raffaella, Leone, Ilaria, Lio, Veronica, Lorenzini, Luca, Maconi, Antonio, Malerba, Mario, Manfredi, Giulia Francesca, Martelli, Maria, Marzari, Letizia, Marzullo, Paolo, Mennuni, Marco, Montabone, Claudia, Morosini, Umberto, Mussa, Marco, Nerici, Ilaria, Nuzzo, Alessandro, Olivieri, Carlo, Padelli, Samuel Alberto, Panella, Massimiliano, Parisini, Andrea, Paschè, Alessio, Pau, Alberto, Pedrinelli, Anita Rebecca, Percivale, Ilaria, Re, Roberta, Rigamonti, Cristina, Rizzi, Eleonora, Rognoni, Andrea, Roveta, Annalisa, Salamina, Luigia, Santagostino, Matteo, Saraceno, Massimo, Savoia, Paola, Sciarra, Marco, Schimmenti, Andrea, Scotti, Lorenza, Spinoni, Enrico, Smirne, Carlo, Tarantino, Vanessa, Tillio, Paolo Amedeo, Vaschetto, Rosanna, Vassia, Veronica, Zagaria, Domenico, Zavattaro, Elisa, Zeppegno, Patrizia, Zottarelli, Francesca, and Sainaghi, Pier Paolo

Published
2020
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12. Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study

Author

Baricich, Alessio, primary, Battaglia, Marco, additional, Cuneo, Daria, additional, Cosenza, Lucia, additional, Millevolte, Marzia, additional, Cosma, Michela, additional, Filippetti, Mirko, additional, Dalise, Stefania, additional, Azzollini, Valentina, additional, Chisari, Carmelo, additional, Spina, Stefania, additional, Cinone, Nicoletta, additional, Scotti, Lorenza, additional, Invernizzi, Marco, additional, Paolucci, Stefano, additional, Picelli, Alessandro, additional, and Santamato, Andrea, additional

Published
2023
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14. Balance Rehabilitation through Robot-Assisted Gait Training in Post-Stroke Patients: A Systematic Review and Meta-Analysis

Author

Loro, Alberto, primary, Borg, Margherita Beatrice, additional, Battaglia, Marco, additional, Amico, Angelo Paolo, additional, Antenucci, Roberto, additional, Benanti, Paolo, additional, Bertoni, Michele, additional, Bissolotti, Luciano, additional, Boldrini, Paolo, additional, Bonaiuti, Donatella, additional, Bowman, Thomas, additional, Capecci, Marianna, additional, Castelli, Enrico, additional, Cavalli, Loredana, additional, Cinone, Nicoletta, additional, Cosenza, Lucia, additional, Di Censo, Rita, additional, Di Stefano, Giuseppina, additional, Draicchio, Francesco, additional, Falabella, Vincenzo, additional, Filippetti, Mirko, additional, Galeri, Silvia, additional, Gimigliano, Francesca, additional, Grigioni, Mauro, additional, Invernizzi, Marco, additional, Jonsdottir, Johanna, additional, Lentino, Carmelo, additional, Massai, Perla, additional, Mazzoleni, Stefano, additional, Mazzon, Stefano, additional, Molteni, Franco, additional, Morelli, Sandra, additional, Morone, Giovanni, additional, Nardone, Antonio, additional, Panzeri, Daniele, additional, Petrarca, Maurizio, additional, Posteraro, Federico, additional, Santamato, Andrea, additional, Scotti, Lorenza, additional, Senatore, Michele, additional, Spina, Stefania, additional, Taglione, Elisa, additional, Turchetti, Giuseppe, additional, Varalta, Valentina, additional, Picelli, Alessandro, additional, and Baricich, Alessio, additional

Published
2023
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16. Worse Disease Prognosis Is Associated to an Increase of Platelet-Derived Extracellular Vesicles in Hospitalized SARS-CoV-2 Patients

Author

Raineri, Davide, primary, Venegoni, Chiara, additional, Calella, Maria Grazia, additional, Vaschetto, Rosanna, additional, Scotti, Lorenza, additional, Canciani, Elena, additional, Manfredi, Marcello, additional, Gavelli, Francesco, additional, Castello, Luigi, additional, Chiocchetti, Annalisa, additional, and Cappellano, Giuseppe, additional

Published
2022
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22. Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19

Author

Vianello, Andrea, primary, De Vita, Nello, additional, Scotti, Lorenza, additional, Guarnieri, Gabriella, additional, Confalonieri, Marco, additional, Bonato, Valeria, additional, Molena, Beatrice, additional, Maestrone, Carlo, additional, Airoldi, Gianluca, additional, Olivieri, Carlo, additional, Sainaghi, Pier Paolo, additional, Lionello, Federico, additional, Arcaro, Giovanna, additional, Della Corte, Francesco, additional, Navalesi, Paolo, additional, and Vaschetto, Rosanna, additional

Published
2022
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28. Determinants of enhanced vulnerability to COVID-19 in UK cancer patients: a European Study

Author

Pinato, David J., Scotti, Lorenza, Gennari, Alessandra, Colomba-Blameble, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Mukherjee, Uma, Zambelli, Alberto, Aguilar-Company, Juan, Bower, Mark, Galazi, Myria, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Sita-Lumsden, Ailsa, Colomba, Johann, Pommeret, Fanny, Seguí, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Rizzo, Gianpiero, Libertini, Michela, Moss, Charlotte, Evans, Joanne S., Russell, Beth, Wuerstlein, Rachel, Vincenzi, Bruno, Bertulli, Rossella, Ottaviani, Diego, Liñan, Raquel, Marrari, Andrea, Carmona-García, M. Carmen, Sng, Christopher CT., Tondini, Carlo, Mirallas, Oriol, Tovazzi, Valeria, Fotia, Vittoria, Cruz, Claudia Andrea, Saoudi-Gonzalez, Nadia, Felip, Eudald, Roqué Lloveras, Ariadna, Lee, Alvin J.X., Newsom-Davis, Thomas, Sharkey, Rachel, Chung, Chris, García-Illescas, David, Reyes, Roxana, Sophia Wong, Yien Ning, Ferrante, Daniela, Marco-Hernández, Javier, Ruiz-Camps, Isabel, Gaidano, Gianluca, Patriarca, Andrea, Sureda, Anna, Martinez-Vila, Clara, Sanchez de Torre, Ana, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Krengli, Marco, Santoro, Armando, Prat, Aleix, Tabernero, Josep, Van Hemelrijck, Mieke, Diamantis, Nikolaos, and Cortellini, Alessio

Subjects
Europe, SARS-CoV-2, COVID-19, cancer, UK, Mortality, Original Research
Abstract

Background Despite high contagiousness and rapid spread, SARS-CoV-2 has led to heterogeneous outcomes across affected nations. Within Europe, the United Kingdom (UK) is the most severely affected country, with a death toll in excess of 100.000 as of January 2021. We aimed to compare the national impact of COVID-19 on the risk of death in UK cancer patients versus those in continental Europe (EU). Methods We performed a retrospective analysis of the OnCovid study database, a European registry of cancer patients consecutively diagnosed with COVID-19 in 27 centres from February 27 to September 10, 2020. We analysed case fatality rates and risk of death at 30 days and 6 months stratified by region of origin (UK versus EU). We compared patient characteristics at baseline, including oncological and COVID-19 specific therapy across UK and EU cohorts and evaluated the association of these factors with the risk adverse outcome in multivariable Cox regression models. Findings Compared to EU (n=924), UK patients (n=468) were characterised by higher case fatality rates (40.38% versus 26.5%, p

Published
2021

29. Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19

Author

Bellan, Mattia, primary, Azzolina, Danila, additional, Hayden, Eyal, additional, Gaidano, Gianluca, additional, Pirisi, Mario, additional, Acquaviva, Antonio, additional, Aimaretti, Gianluca, additional, Aluffi Valletti, Paolo, additional, Angilletta, Roberto, additional, Arioli, Roberto, additional, Avanzi, Gian Carlo, additional, Avino, Gianluca, additional, Balbo, Piero Emilio, additional, Baldon, Giulia, additional, Baorda, Francesca, additional, Barbero, Emanuela, additional, Baricich, Alessio, additional, Barini, Michela, additional, Barone-Adesi, Francesco, additional, Battistini, Sofia, additional, Beltrame, Michela, additional, Bertoli, Matteo, additional, Bertolin, Stephanie, additional, Bertolotti, Marinella, additional, Betti, Marta, additional, Bobbio, Flavio, additional, Boffano, Paolo, additional, Boglione, Lucio, additional, Borrè, Silvio, additional, Brucoli, Matteo, additional, Calzaducca, Elisa, additional, Cammarata, Edoardo, additional, Cantaluppi, Vincenzo, additional, Cantello, Roberto, additional, Capponi, Andrea, additional, Carriero, Alessandro, additional, Casciaro, Giuseppe Francesco, additional, Castello, Luigi Mario, additional, Ceruti, Federico, additional, Chichino, Guido, additional, Chirico, Emilio, additional, Cisari, Carlo, additional, Cittone, Micol Giulia, additional, Colombo, Crizia, additional, Comi, Cristoforo, additional, Croce, Eleonora, additional, Daffara, Tommaso, additional, Danna, Pietro, additional, Della Corte, Francesco, additional, De Vecchi, Simona, additional, Dianzani, Umberto, additional, Di Benedetto, Davide, additional, Esposto, Elia, additional, Faggiano, Fabrizio, additional, Falaschi, Zeno, additional, Ferrante, Daniela, additional, Ferrero, Alice, additional, Gagliardi, Ileana, additional, Galbiati, Alessandra, additional, Gallo, Silvia, additional, Garavelli, Pietro Luigi, additional, Gardino, Clara Ada, additional, Garzaro, Massimiliano, additional, Gastaldello, Maria Luisa, additional, Gavelli, Francesco, additional, Gennari, Alessandra, additional, Giacomini, Greta Maria, additional, Giacone, Irene, additional, Giai Via, Valentina, additional, Giolitti, Francesca, additional, Gironi, Laura Cristina, additional, Gramaglia, Carla, additional, Grisafi, Leonardo, additional, Inserra, Ilaria, additional, Invernizzi, Marco, additional, Krengli, Marco, additional, Labella, Emanuela, additional, Landi, Irene Cecilia, additional, Landi, Raffaella, additional, Leone, Ilaria, additional, Lio, Veronica, additional, Lorenzini, Luca, additional, Maconi, Antonio, additional, Malerba, Mario, additional, Manfredi, Giulia Francesca, additional, Martelli, Maria, additional, Marzari, Letizia, additional, Marzullo, Paolo, additional, Mennuni, Marco, additional, Montabone, Claudia, additional, Morosini, Umberto, additional, Mussa, Marco, additional, Nerici, Ilaria, additional, Nuzzo, Alessandro, additional, Olivieri, Carlo, additional, Padelli, Samuel Alberto, additional, Panella, Massimiliano, additional, Parisini, Andrea, additional, Paschè, Alessio, additional, Patrucco, Filippo, additional, Patti, Giuseppe, additional, Pau, Alberto, additional, Pedrinelli, Anita Rebecca, additional, Percivale, Ilaria, additional, Ragazzoni, Luca, additional, Re, Roberta, additional, Rigamonti, Cristina, additional, Rizzi, Eleonora, additional, Rognoni, Andrea, additional, Roveta, Annalisa, additional, Salamina, Luigia, additional, Santagostino, Matteo, additional, Saraceno, Massimo, additional, Savoia, Paola, additional, Sciarra, Marco, additional, Schimmenti, Andrea, additional, Scotti, Lorenza, additional, Spinoni, Enrico, additional, Smirne, Carlo, additional, Tarantino, Vanessa, additional, Tillio, Paolo Amedeo, additional, Tonello, Stelvio, additional, Vaschetto, Rosanna, additional, Vassia, Veronica, additional, Zagaria, Domenico, additional, Zavattaro, Elisa, additional, Zeppegno, Patrizia, additional, Zottarelli, Francesca, additional, and Sainaghi, Pier Paolo, additional

Published
2021
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30. Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score

Author

Dettorre, Gino M., Dolly, Saoirse, Loizidou, Angela, Chester, John, Jackson, Amanda, Mukherjee, Uma, Zambelli, Alberto, Aguilar Company, Juan, Bower, Mark, Sng, Christopher C. T., Salazar Soler, Ramón, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Sita-Lumsden, Ailsa, Seguí, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Seeva, Pavetha, Rizzo, Gianpiero, Libertini, Michela, Maconi, Antonio, Moss, Charlotte, Russell, Beth, Harbeck, Nadia, Vincenzi, Bruno, Bertulli, Rossella, Ottaviani, Diego, Liñan, Raquel, Marrari, Andrea, Carmona García, M. Carmen, Chopra, Neha, Tondini, Carlo Alberto, Mirallas, Oriol, Tovazzi, Valeria, Fotia, Vittoria, Cruz, Claudia Andrea, Saoudi González, Nadia, Felip, Eudald, Roqué, Ariadna, Lee, Alvin J. X., Newsom-Davis, Tom, García Illescas, David, Reyes, Roxana, Wong, Yien Ning Sophia, Ferrante, Daniela, Scotti, Lorenza, Marco Hernández, Javier, Ruiz Camps, Isabel, Patriarca, Andrea, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Santoro, Armando, Prat Aparicio, Aleix, Gennari, Alessandra, Van Hemelrijck, Mieke, Tabernero Caturla, Josep, Diamantis, Nikolaos, Pinato, David J., OnCovid study group, Dettorre, G. M., Dolly, S., Loizidou, A., Chester, J., Jackson, A., Mukherjee, U., Zambelli, A., Aguilar-Company, J., Bower, M., Sng, C. C. T., Salazar, R., Bertuzzi, A., Brunet, J., Mesia, R., Sita-Lumsden, A., Segui, E., Biello, F., Generali, D., Grisanti, S., Seeva, P., Rizzo, G., Libertini, M., Maconi, A., Moss, C., Russell, B., Harbeck, N., Vincenzi, B., Bertulli, R., Ottaviani, D., Linan, R., Marrari, A., Carmen Carmona-Garcia, M., Chopra, N., Tondini, C. A., Mirallas, O., Tovazzi, V., Fotia, V., Cruz, C. A., Saoudi-Gonzalez, N., Felip, E., Roque, A., Lee, A. J. X., Newsom-Davis, T., Garcia-Illescas, D., Reyes, R., Wong, Y. N. S., Ferrante, D., Scotti, L., Marco-Hernandez, J., Ruiz-Camps, I., Patriarca, A., Rimassa, L., Chiudinelli, L., Franchi, M., Santoro, A., Prat, A., Gennari, A., Van Hemelrijck, M., Tabernero, J., Diamantis, N., Pinato, D. J., Wellcome Trust, Institut Català de la Salut, [Dettorre GM] Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, UK. [Dolly S] Medical Oncology, Guy’s and St Thomas’ NHS Foundation Trust (GSTT), London, UK. [Loizidou A] Department of Infectious Diseases, Internal Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. [Chester J] Medical Oncology, School of Medicine, Cardiff University, Cardiff, UK. Medical Oncology, Velindre Cancer Centre, Cardiff, UK. [Jackson A] Clinical Trials, Velindre Cancer Centre, Cardiff, UK. [Mukherjee U] Medical Oncology, Barts Health NHS Trust, London, UK. [Aguilar-Company J] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Mirallas O, Saoudi-Gonzalez N, García-Illescas D] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Ruiz-Camps I] Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Tabernero J] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. IOB-Quiron, UVic-UCC, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Male, 0301 basic medicine, Oncology, Cancer Research, Comorbidity, Systemic inflammation, Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores], COVID-19 Testing, 0302 clinical medicine, Neoplasms, Immunotherapy Biomarkers, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], 80 and over, Immunology and Allergy, Medicine, Hypoalbuminemia, Young adult, Càncer, Multivariate Analysi, RC254-282, COVID-19 (Malaltia) - Complicacions, Cancer, Aged, 80 and over, OnCovid study group, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Middle Aged, Prognosis, Inflamació, Systemic Inflammatory Response Syndrome, 030220 oncology & carcinogenesis, Cohort, Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation::Systemic Inflammatory Response Syndrome [DISEASES], Molecular Medicine, Female, medicine.symptom, Life Sciences & Biomedicine, Human, Adult, medicine.medical_specialty, Prognosi, Càncer - Epidemiologia, Immunology, neoplasias [ENFERMEDADES], inflammation mediator, Young Adult, 03 medical and health sciences, Internal medicine, Humans, afecciones patológicas, signos y síntomas::procesos patológicos::inflamación::síndrome de respuesta inflamatoria sistémica [ENFERMEDADES], Aged, Pharmacology, Science & Technology, business.industry, SARS-CoV-2, COVID-19, medicine.disease, inflammation, inflammation mediators, Blood Cell Count, Multivariate Analysis, Neoplasms [DISEASES], Systemic inflammatory response syndrome, 030104 developmental biology, Neoplasm, Lymphocytopenia, business, Other subheadings::Other subheadings::/complications [Other subheadings]
Abstract

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflamació; Mediadors d'inflamació Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflamación; Mediadores de la inflamación Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflammation; Inflammation mediators Background Patients with cancer are particularly susceptible to SARS-CoV-2 infection. The systemic inflammatory response is a pathogenic mechanism shared by cancer progression and COVID-19. We investigated systemic inflammation as a driver of severity and mortality from COVID-19, evaluating the prognostic role of commonly used inflammatory indices in SARS-CoV-2-infected patients with cancer accrued to the OnCovid study. Methods In a multicenter cohort of SARS-CoV-2-infected patients with cancer in Europe, we evaluated dynamic changes in neutrophil:lymphocyte ratio (NLR); platelet:lymphocyte ratio (PLR); Prognostic Nutritional Index (PNI), renamed the OnCovid Inflammatory Score (OIS); modified Glasgow Prognostic Score (mGPS); and Prognostic Index (PI) in relation to oncological and COVID-19 infection features, testing their prognostic potential in independent training (n=529) and validation (n=542) sets. Results We evaluated 1071 eligible patients, of which 625 (58.3%) were men, and 420 were patients with malignancy in advanced stage (39.2%), most commonly genitourinary (n=216, 20.2%). 844 (78.8%) had ≥1 comorbidity and 754 (70.4%) had ≥1 COVID-19 complication. NLR, OIS, and mGPS worsened at COVID-19 diagnosis compared with pre-COVID-19 measurement (p

Published
2021

31. COVID-19 Sequelae and the Host Proinflammatory Response: An Analysis From the OnCovid Registry.

Author

Cortellini, Alessio, Gennari, Alessandra, Pommeret, Fanny, Patel, Grisma, Newsom-Davis, Thomas, Bertuzzi, Alexia, Viladot, Margarita, Aguilar-Company, Juan, Mirallas, Oriol, Felip, Eudald, Lee, Alvin J X, Pria, Alessia Dalla, Sharkey, Rachel, Brunet, Joan, Carmona-García, MCarmen, Chester, John, Mukherjee, Uma, Scotti, Lorenza, Dolly, Saoirse, and Sita-Lumsden, Ailsa

Abstract

Background: Fifteen percent of patients with cancer experience symptomatic sequelae, which impair post-COVID-19 outcomes. In this study, we investigated whether a proinflammatory status is associated with the development of COVID-19 sequelae.Methods: OnCovid recruited 2795 consecutive patients who were diagnosed with Severe Acute Respiratory Syndrome Coronavirus 2 infection between February 27, 2020, and February 14, 2021. This analysis focused on COVID-19 survivors who underwent a clinical reassessment after the exclusion of patients with hematological malignancies. We evaluated the association of inflammatory markers collected at COVID-19 diagnosis with sequelae, considering the impact of previous systemic anticancer therapy. All statistical tests were 2-sided.Results: Of 1339 eligible patients, 203 experienced at least 1 sequela (15.2%). Median baseline C-reactive protein (CRP; 77.5 mg/L vs 22.2 mg/L, P < .001), lactate dehydrogenase (310 UI/L vs 274 UI/L, P = .03), and the neutrophil to lymphocyte ratio (NLR; 6.0 vs 4.3, P = .001) were statistically significantly higher among patients who experienced sequelae, whereas no association was reported for the platelet to lymphocyte ratio and the OnCovid Inflammatory Score, which includes albumin and lymphocytes. The widest area under the ROC curve (AUC) was reported for baseline CRP (AUC = 0.66, 95% confidence interval [CI]: 0.63 to 0.69), followed by the NLR (AUC = 0.58, 95% CI: 0.55 to 0.61) and lactate dehydrogenase (AUC = 0.57, 95% CI: 0.52 to 0.61). Using a fixed categorical multivariable analysis, high CRP (odds ratio [OR] = 2.56, 95% CI: 1.67 to 3.91) and NLR (OR = 1.45, 95% CI: 1.01 to 2.10) were confirmed to be statistically significantly associated with an increased risk of sequelae. Exposure to chemotherapy was associated with a decreased risk of sequelae (OR = 0.57, 95% CI: 0.36 to 0.91), whereas no associations with immune checkpoint inhibitors, endocrine therapy, and other types of systemic anticancer therapy were found.Conclusions: Although the association between inflammatory status, recent chemotherapy and sequelae warrants further investigation, our findings suggest that a deranged proinflammatory reaction at COVID-19 diagnosis may predict for sequelae development. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score

Author

Dettorre, Gino M, primary, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Jackson, Amanda, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher C T, additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Mesia, Ricard, additional, Sita-Lumsden, Ailsa, additional, Seguí, Elia, additional, Biello, Federica, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Seeva, Pavetha, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Moss, Charlotte, additional, Russell, Beth, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Ottaviani, Diego, additional, Liñan, Raquel, additional, Marrari, Andrea, additional, Carmona-García, M Carmen, additional, Chopra, Neha, additional, Tondini, Carlo Alberto, additional, Mirallas, Oriol, additional, Tovazzi, Valeria, additional, Fotia, Vittoria, additional, Cruz, Claudia Andrea, additional, Saoudi-Gonzalez, Nadia, additional, Felip, Eudald, additional, Roqué, Ariadna, additional, Lee, Alvin J X, additional, Newsom-Davis, Tom, additional, García-Illescas, David, additional, Reyes, Roxana, additional, Wong, Yien Ning Sophia, additional, Ferrante, Daniela, additional, Scotti, Lorenza, additional, Marco-Hernández, Javier, additional, Ruiz-Camps, Isabel, additional, Patriarca, Andrea, additional, Rimassa, Lorenza, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Santoro, Armando, additional, Prat, Aleix, additional, Gennari, Alessandra, additional, Van Hemelrijck, Mieke, additional, Tabernero, Josep, additional, Diamantis, Nikolaos, additional, and Pinato, David J, additional

Published
2021
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33. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe

Author

Pinato, David J., Lee, Alvin J.X., Biello, Federica, Seguí, Elia, Aguilar-Company, Juan, Carbó, Anna, Bruna, Riccardo, Bower, Mark, Rizzo, Gianpiero, Benafif, Sarah, Carmona, Carme, Chopra, Neha, Cruz, Claudia Andrea, D'avanzo, Francesca, Evans, Joanne S., Galazi, Myria, Garcia-Fructuoso, Isabel, Pria, Alessia D., Newsom-Davis, Thomas, Ottaviani, Diego, Patriarca, Andrea, Reyes, Roxana, Sharkey, Rachel, Sng, Christopher C.T., Wong, Yien Ning Sophia, Ferrante, Daniela, Scotti, Lorenza, Avanzi, Gian Carlo, Bellan, Mattia, Castello, Luigi Mario, Marco-Hernández, Javier, Mollà, Meritxell, Pirisi, Mario, Ruiz-Camps, Isabel, Sainaghi, Pier Paolo, Gaidano, Gianluca, Brunet, Joan, Tabernero, Josep, Prat, Aleix, Gennari, Alessandra, Universitat Autònoma de Barcelona, Pinato, David J., Lee, Alvin J.X., Biello, Federica, Seguí, Elia, Aguilar-Company, Juan, Carbó, Anna, Bruna, Riccardo, Bower, Mark, Rizzo, Gianpiero, Benafif, Sarah, Carmona, Carme, Chopra, Neha, Cruz, Claudia Andrea, D'avanzo, Francesca, Evans, Joanne S., Galazi, Myria, Garcia-Fructuoso, Isabel, Pria, Alessia D., Newsom-Davis, Thomas, Ottaviani, Diego, Patriarca, Andrea, Reyes, Roxana, Sharkey, Rachel, Sng, Christopher C.T., Wong, Yien Ning Sophia, Ferrante, Daniela, Scotti, Lorenza, Avanzi, Gian Carlo, Bellan, Mattia, Castello, Luigi Mario, Marco-Hernández, Javier, Mollà, Meritxell, Pirisi, Mario, Ruiz-Camps, Isabel, Sainaghi, Pier Paolo, Gaidano, Gianluca, Brunet, Joan, Tabernero, Josep, Prat, Aleix, Gennari, Alessandra, and Universitat Autònoma de Barcelona

Abstract

Funding: D.J.P. is supported by grant funding from the Wellcome Trust Strategic Fund (PS3416) and acknowledges grant support by the Cancer Treatment and Research Trust (CTRT) as well as infrastructural support by the Cancer Research UK Imperial Centre. GG is supported by the AIRC 5 × 1000 Grant, No. 21198, Associazione Italiana per la Ricerca sul Cancro Foundation, Milan, Italy. A.G. is supported by the AIRC IG grant, No. 14230, Associazione Italiana per la Ricerca sul Cancro Foundation, Milan, Italy. A.G., G.G., G.C.A., L.M.C., M.B., P.P.S., M.P. from the University of Piemonte Orientale acknowledge support from the UPO Aging Project., We describe the outcomes in cancer patients during the initial outbreak of the COVID-19 in Europe from the retrospective, multi-center observational OnCovid study. We identified 204 cancer patients from eight centers in the United Kingdom, Italy, and Spain aged > 18 (mean = 69) and diagnosed with COVID-19 between February 26th and April 1st, 2020. A total of 127 (62%) were male, 184 (91%) had a diagnosis of solid malignancy, and 103 (51%) had non-metastatic disease. A total of 161 (79%) had > 1 co-morbidity. A total of 141 (69%) patients had > 1 COVID-19 complication. A total of 36 (19%) were escalated to high-dependency or intensive care. A total of 59 (29%) died, 53 (26%) were discharged, and 92 (45%) were in-hospital survivors. Mortality was higher in patients aged > 65 (36% versus 16%), in those with > 2 co-morbidities (40% versus 18%) and developing > 1 complication from COVID-19 (38% versus 4%, p = 0.004). Multi-variable analyses confirmed age > 65 and > 2 co-morbidities to predict for patient mortality independent of tumor stage, active malignancy, or anticancer therapy. During the early outbreak of SARS-CoV-2 infection in Europe co-morbid burden and advancing age predicted for adverse disease course in cancer patients. The ongoing OnCovid study will allow us to compare risks and outcomes in cancer patients between the initial and later stages of the COVID-19 pandemic.

Published
2020

34. Diurnal Measurements of Macular Thickness and Vessel Density on OCT Angiography in Healthy Eyes and Those with Ocular Hypertension and Glaucoma

Author

Milani, P, Bochicchio, S, Urbini, L, Bulone, E, Callegarin, S, Pisano, L, Scotti, L, Zambon, A, Bergamini, F, Milani, Paolo, Bochicchio, Sara, Urbini, Lara Enrica, Bulone, Ennio, Callegarin, Stefania, Pisano, Luca, Scotti, Lorenza, Zambon, Antonella, Bergamini, Fulvio, Milani, P, Bochicchio, S, Urbini, L, Bulone, E, Callegarin, S, Pisano, L, Scotti, L, Zambon, A, Bergamini, F, Milani, Paolo, Bochicchio, Sara, Urbini, Lara Enrica, Bulone, Ennio, Callegarin, Stefania, Pisano, Luca, Scotti, Lorenza, Zambon, Antonella, and Bergamini, Fulvio

Abstract

Precis:Macular superficial capillary plexus (SCP) and thickness are reduced in eyes with glaucoma and ocular hypertension, but do not change significantly during the day. No relationships with age, intraocular pressure, systemic hypertension, or axial length were found.Purpose:The purpose of this study was to evaluate diurnal differences in retinal thickness and vessel density (VD) of the macular SCP and deep capillary plexus (DCP) using optical coherence tomography angiography among 3 groups: eyes with glaucoma, eyes with ocular hypertension, and healthy eyes.Methods:A consecutive series of individuals was recruited prospectively. Optical coherence tomography angiography was performed in the morning and in the evening.Results:Forty eyes from 23 individuals with glaucoma (58.35±6 y), 52 eyes from 32 individuals with ocular hypertension (58.84±7 y), and 73 eyes from 44 controls (57.84±6 y) were enrolled. Morning and evening measurements of all SCP-VD and retinal thickness parameters were statistically significantly different (P<0.04) among the 3 groups of eyes. None of the DCP-VD parameters were significantly different. Daily changes in SCP-VD, DCP-VD, and retinal thickness among the groups of eyes were not statistically significant. Systemic hypertension, age, axial length, and diurnal changes in intraocular pressure were not significantly associated with diurnal fluctuations of SCP-VD, DCP-VD, or retinal thickness (P>0.19). A positive linear correlation in diurnal changes was found between SCP-VD and DCP-VD in the fovea and in the parafovea (r=0.5567 and 0.5892, respectively) and between SCP-VD and retinal thickness in the fovea and in the parafovea (r=-0.2288 and 0.2418, respectively).Conclusions:Macular SCP-VD and thickness are reduced in eyes with glaucoma and ocular hypertension. Although diurnal changes in SCP-VD, DCP-VD and macular thickness were not significant among the groups, some linear correlations in increasing or decreasing values of the investigated

Published
2020

36. Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection

Author

Cappellano, Giuseppe, primary, Raineri, Davide, additional, Rolla, Roberta, additional, Giordano, Mara, additional, Puricelli, Chiara, additional, Vilardo, Beatrice, additional, Manfredi, Marcello, additional, Cantaluppi, Vincenzo, additional, Sainaghi, Pier Paolo, additional, Castello, Luigi, additional, De Vita, Nello, additional, Scotti, Lorenza, additional, Vaschetto, Rosanna, additional, Dianzani, Umberto, additional, and Chiocchetti, Annalisa, additional

Published
2021
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37. Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective

Author

Soosaipillai, Gehan, primary, Wu, Anjui, additional, Dettorre, Gino M, additional, Diamantis, Nikolaos, additional, Chester, John, additional, Moss, Charlotte, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher CT, additional, Salazar, Ramon, additional, Brunet, Joan, additional, Jones, Eleanor, additional, Mesia, Ricard, additional, Jackson, Amanda, additional, Mukherjee, Uma, additional, Sita-Lumsden, Ailsa, additional, Seguí, Elia, additional, Ottaviani, Diego, additional, Carbó, Anna, additional, Benafif, Sarah, additional, Würstlein, Rachel, additional, Carmona, Carme, additional, Chopra, Neha, additional, Cruz, Claudia Andrea, additional, Swallow, Judith, additional, Saoudi, Nadia, additional, Felip, Eudald, additional, Galazi, Myria, additional, Garcia-Fructuoso, Isabel, additional, Lee, Alvin J. X., additional, Newsom-Davis, Thomas, additional, Wong, Yien Ning Sophia, additional, Sureda, Anna, additional, Maluquer, Clara, additional, Ruiz-Camps, Isabel, additional, Cabirta, Alba, additional, Prat, Aleix, additional, Loizidou, Angela, additional, Gennari, Alessandra, additional, Ferrante, Daniela, additional, Tabernero, Josep, additional, Russell, Beth, additional, Van Hemelrijck, Mieke, additional, Dolly, Saoirse, additional, Hulbert-Williams, Nicholas J, additional, Pinato, David J, additional, Mollà, Meritxell, additional, Reyes, Roxana, additional, Marco-Hernández, Javier, additional, Bruna, Riccardo, additional, Biello, Federica, additional, Patriarca, Andrea, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Fotia, Vittoria, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Tovazzi, Valeria, additional, Bertuzzi, Alexia, additional, Marrari, Andrea, additional, Seeva, Pavetha, additional, Dileo, Palma, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Betti, Marta, additional, Provenzano, Salvatore, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Liñan, Raquel, additional, Roqué, Ariadna, additional, Mirallas, Oriol, additional, García-Illescas, David, additional, Scotti, Lorenza, additional, Dalla Pria, Alessia, additional, D’Avanzo, Francesca, additional, Martinez, Maria, additional, Evans, Joanne S, additional, Sharkey, Rachel, additional, Rimassa, Lorenza, additional, Santoro, Armando, additional, Gaidano, Gianluca, additional, and Izuzquiza, Macarena, additional

Published
2021
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39. Outcomes of COVID-19 patients treated with continuous positive airway pressure outside the intensive care unit

Author

Vaschetto, Rosanna, primary, Barone-Adesi, Francesco, additional, Racca, Fabrizio, additional, Pissaia, Claudio, additional, Maestrone, Carlo, additional, Colombo, Davide, additional, Olivieri, Carlo, additional, De Vita, Nello, additional, Santangelo, Erminio, additional, Scotti, Lorenza, additional, Castello, Luigi, additional, Cena, Tiziana, additional, Taverna, Martina, additional, Grillenzoni, Luca, additional, Moschella, Maria Adele, additional, Airoldi, Gianluca, additional, Borrè, Silvio, additional, Mojoli, Francesco, additional, Della Corte, Francesco, additional, Baggiani, Marta, additional, Baino, Sara, additional, Balbo, Piero, additional, Bazzano, Simona, additional, Bonato, Valeria, additional, Carbonati, Sara, additional, Crimaldi, Federico, additional, Daffara, Veronica, additional, De Col, Luca, additional, Maestrone, Matteo, additional, Malerba, Mario, additional, Moroni, Federica, additional, Perucca, Raffaella, additional, Pirisi, Mario, additional, Rondi, Valentina, additional, Rosalba, Daniela, additional, Vanni, Letizia, additional, Vigone, Francesca, additional, Navalesi, Paolo, additional, and Cammarota, Gianmaria, additional

Published
2020
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41. Presenting Features and Early Mortality from SARS-CoV-2 Infection in Cancer Patients during the Initial Stage of the COVID-19 Pandemic in Europe

Author

Pinato, David J., primary, Lee, Alvin J. X., additional, Biello, Federica, additional, Seguí, Elia, additional, Aguilar-Company, Juan, additional, Carbó, Anna, additional, Bruna, Riccardo, additional, Bower, Mark, additional, Rizzo, Gianpiero, additional, Benafif, Sarah, additional, Carmona, Carme, additional, Chopra, Neha, additional, Cruz, Claudia Andrea, additional, D’Avanzo, Francesca, additional, Evans, Joanne S., additional, Galazi, Myria, additional, Garcia-Fructuoso, Isabel, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Ottaviani, Diego, additional, Patriarca, Andrea, additional, Reyes, Roxana, additional, Sharkey, Rachel, additional, Sng, Christopher C. T., additional, Wong, Yien Ning Sophia, additional, Ferrante, Daniela, additional, Scotti, Lorenza, additional, Avanzi, Gian Carlo, additional, Bellan, Mattia, additional, Castello, Luigi Mario, additional, Marco-Hernández, Javier, additional, Mollà, Meritxell, additional, Pirisi, Mario, additional, Ruiz-Camps, Isabel, additional, Sainaghi, Pier Paolo, additional, Gaidano, Gianluca, additional, Brunet, Joan, additional, Tabernero, Josep, additional, Prat, Aleix, additional, and Gennari, Alessandra, additional

Published
2020
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42. A pragmatic controlled trial to improve the appropriate prescription of drugs in adult outpatients: design and rationale of the EDU.RE.DRUG study

Author

Casula, Manuela, primary, Menditto, Enrica, additional, Galimberti, Federica, additional, Russo, Veronica, additional, Olmastroni, Elena, additional, Scotti, Lorenza, additional, Orlando, Valentina, additional, Corrao, Giovanni, additional, Catapano, Alberico L., additional, and Tragni, Elena, additional

Published
2020
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43. Diurnal Stability Of Peripapillary Vessel Density And Nerve Fiber Layer Thickness On Optical Coherence Tomography Angiography In Healthy, Ocular Hypertension And Glaucoma Eyes

Author

Bochicchio,Sara, Milani,Paolo, Urbini,Lara Enrica, Bulone,Ennio, Carmassi,Luciana, Fratantonio,Elena, Castegna,Giacomo, Scotti,Lorenza, Zambon,Antonella, Bergamini,Fulvio, Bochicchio,Sara, Milani,Paolo, Urbini,Lara Enrica, Bulone,Ennio, Carmassi,Luciana, Fratantonio,Elena, Castegna,Giacomo, Scotti,Lorenza, Zambon,Antonella, and Bergamini,Fulvio

Abstract

Sara Bochicchio,1 Paolo Milani,1 Lara Enrica Urbini,1 Ennio Bulone,1 Luciana Carmassi,1 Elena Fratantonio,1 Giacomo Castegna,1 Lorenza Scotti,2 Antonella Zambon,2 Fulvio Bergamini1 1Ophthalmology Department, Istituto Auxologico Italiano, Milan, Italy; 2Statistics and Quantitative Methods Department, University of Milano-Bicocca, Milan, ItalyCorrespondence: Paolo MilaniIstituto Auxologico Italiano, Via Mercalli 30, Milan, ItalyTel +39 2 3385840232Fax +39 2 20422262Email dottpaolomilani@hotmail.comPurpose: By using optical coherence tomography angiography (OCTA), to evaluate diurnal changes of the following parameters: vessel density in the peripapillary area (PP-VD) and in the optic nerve head (ONH-VD); thickness of retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC).Methods: All prospectively enrolled participants were imaged on the same day at 8 am and 7 pm by means of the XR Avanti device with AngioVue and AngioAnalytics software (Optovue Inc., Fremont, CA, USA). Only eyes with correct automatic segmentation and good-quality images (scan quality > 7/10) were included.Results: Forty-six eyes from 28 patients with glaucoma, 53 from 31 patients with ocular hypertension, and 62 from 38 controls were assessed. The mean measurements of all parameters investigated were significantly different in the morning and in the evening values in all three groups, with lower values in glaucomatous eyes (p<0.014). In control eyes, as well as in eyes of patients with ocular hypertension and glaucoma the daily changes were minimal and not statistically significant with means of +0.17%, −0.31% and −0.54% for ONH-VD (p=0.83) and means of +0.2%, +0.1% and +0.29% for PP-VD (p=0.83), respectively. Likewise, daily fluctuations in GCC and RNFL thickness were not significant in any of the three groups, with means of +0.16 μm, +0.66 μm and −0.15 μm for GCC (p=0.58) and means of +0.24 μm, +0.58 μm and &a

Published
2019

44. Diurnal Stability Of Peripapillary Vessel Density And Nerve Fiber Layer Thickness On Optical Coherence Tomography Angiography In Healthy, Ocular Hypertension And Glaucoma Eyes

Author

Bochicchio, Sara, primary, Milani, Paolo, additional, Urbini, Lara Enrica, additional, Bulone, Ennio, additional, Carmassi, Luciana, additional, Fratantonio, Elena, additional, Castegna, Giacomo, additional, Scotti, Lorenza, additional, Zambon, Antonella, additional, and Bergamini, Fulvio, additional

Published
2019
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46. Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project

Author

Masclee, Gwen M. C., primary, Straatman, Huub, additional, Arfè, Andrea, additional, Castellsague, Jordi, additional, Garbe, Edeltraut, additional, Herings, Ron, additional, Kollhorst, Bianca, additional, Lucchi, Silvia, additional, Perez-Gutthann, Susana, additional, Romio, Silvana, additional, Schade, René, additional, Schink, Tania, additional, Schuemie, Martijn J., additional, Scotti, Lorenza, additional, Varas-Lorenzo, Cristina, additional, Valkhoff, Vera E., additional, Villa, Marco, additional, and Sturkenboom, Miriam C. J. M., additional

Published
2018
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47. Risk of acute myocardial infarction during use of individual NSAIDs : A nested case-control study from the SOS project

Author

Masclee, Gwen M C, Straatman, Huub, Arfè, Andrea, Castellsague, Jordi, Garbe, Edeltraut, Herings, Ron, Kollhorst, Bianca, Lucchi, Silvia, Perez-Gutthann, Susana, Romio, Silvana, Schade, René, Schink, Tania, Schuemie, Martijn J, Scotti, Lorenza, Varas-Lorenzo, Cristina, Valkhoff, Vera E, Villa, Marco, Sturkenboom, Miriam C J M, Masclee, Gwen M C, Straatman, Huub, Arfè, Andrea, Castellsague, Jordi, Garbe, Edeltraut, Herings, Ron, Kollhorst, Bianca, Lucchi, Silvia, Perez-Gutthann, Susana, Romio, Silvana, Schade, René, Schink, Tania, Schuemie, Martijn J, Scotti, Lorenza, Varas-Lorenzo, Cristina, Valkhoff, Vera E, Villa, Marco, and Sturkenboom, Miriam C J M

Published
2018

48. Adherence to Antidepressants and Mortality in Elderly Patients with Cardiovascular Disease

Author

Biffi, Annalisa, Scotti, Lorenza, Rea, Federico, Lucenteforte, Ersilia, Chinellato, Alessandro, Vetrano, Davide L., Vitale, Cristiana, Agabiti, Nera, Sultana, Janet, Roberto, Giuseppe, Mugelli, Alessandro, Corrao, Giovanni, Biffi, Annalisa, Scotti, Lorenza, Rea, Federico, Lucenteforte, Ersilia, Chinellato, Alessandro, Vetrano, Davide L., Vitale, Cristiana, Agabiti, Nera, Sultana, Janet, Roberto, Giuseppe, Mugelli, Alessandro, and Corrao, Giovanni

Abstract

Background and Objective Conflicting findings from studies evaluating the association between use of antidepressant drugs and mortality have been reported. We tested the hypothesis that better adherence to antidepressant therapy may reduce mortality. Methods The cohort included 29,845 individuals aged >= 65 years from several Italian health units who were newly treated with antidepressant drugs after hospital discharge with a diagnosis for cardiovascular disease during 2008-2010. These individuals were observed from the first prescription until the end of data availability (i.e. 2012-2014, depending on the local database). During this period, information on (1) prescription of antidepressants and other medications and (2) death from any cause (outcome) was recorded. Proportional hazards models were fitted to estimate the association between better adherence to antidepressants (defined as proportion of days covered > 75%) and outcome, by adjusting and stratifying for several covariates. Results Patients with better adherence to antidepressants had a reduced mortality of 9% (95% CI 3-14). Patients who did not use other medicaments during follow-up had reduced mortality associated with better adherence to antidepressants of 21% (- 1-38), 14% (7-20), 20% (13-26) and 13% (7-19) for no users of antihypertensive agents, lipid-lowering agents, other cardiovascular drugs and antidiabetics, respectively. Conclusions Better adherence to antidepressants is associated with reduced all-cause mortality, mainly in patients who did not use other pharmacological treatments. Behavioural changes to enhance adherence among the elderly with cardiovascular disease might offer important benefits in reducing their mortality.

Published
2018
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49. Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project

Author

Masclee, G, Straatman, H, Arfè, A, Castellsague, J, Garbe, E, Herings, R, Kollhorst, B, Lucchi, S, Perez-Gutthann, S, Romio, S, Schade, R, Schink, T, Schuemie, M, Scotti, L, Varas-Lorenzo, C, Valkhoff, V, Villa, M, Sturkenboom, M, Masclee, Gwen M C, Straatman, Huub, Arfè, Andrea, Castellsague, Jordi, Garbe, Edeltraut, Herings, Ron, Kollhorst, Bianca, Lucchi, Silvia, Perez-Gutthann, Susana, Romio, Silvana, Schade, René, Schink, Tania, Schuemie, Martijn J., Scotti, Lorenza, Varas-Lorenzo, Cristina, Valkhoff, Vera E., Villa, Marco, Sturkenboom, Miriam C J M, Masclee, G, Straatman, H, Arfè, A, Castellsague, J, Garbe, E, Herings, R, Kollhorst, B, Lucchi, S, Perez-Gutthann, S, Romio, S, Schade, R, Schink, T, Schuemie, M, Scotti, L, Varas-Lorenzo, C, Valkhoff, V, Villa, M, Sturkenboom, M, Masclee, Gwen M C, Straatman, Huub, Arfè, Andrea, Castellsague, Jordi, Garbe, Edeltraut, Herings, Ron, Kollhorst, Bianca, Lucchi, Silvia, Perez-Gutthann, Susana, Romio, Silvana, Schade, René, Schink, Tania, Schuemie, Martijn J., Scotti, Lorenza, Varas-Lorenzo, Cristina, Valkhoff, Vera E., Villa, Marco, and Sturkenboom, Miriam C J M

Abstract

OBJECTIVES: To estimate the risk of AMI for individual NSAIDs.METHODS: A nested case-control study was performed from a cohort of new NSAID users ≥18 years (1999-2011) matching cases to a maximum of 100 controls on database, sex, age, and calendar time. Data were retrieved from six healthcare databases. Adjusted odds ratios (ORs) of current use of individual NSAIDs compared to past use were estimated per database. Pooling was done by two-stage pooling using a random effects model (ORmeta) and by one-stage pooling (ORpool).RESULTS: Among 8.5 million new NSAID users, 79,553 AMI cases were identified. The risk was elevated for current use of ketorolac (ORmeta 2.06;95%CI 1.83-2.32, ORpool 1.80; 1.49-2.18) followed, in descending order of point estimate, by indometacin, etoricoxib, rofecoxib, diclofenac, fixed combination of diclofenac with misoprostol, piroxicam, ibuprofen, naproxen, celecoxib, meloxicam, nimesulide and ketoprofen (ORmeta 1.12; 1.03-1.22, ORpool 1.00;0.86-1.16). Higher doses showed higher risk estimates than lower doses.CONCLUSIONS: The relative risk estimates of AMI differed slightly between 28 individual NSAIDs. The relative risk was highest for ketorolac and was correlated with COX-2 potency, but not restricted to coxibs.BACKGROUND: Use of selective COX-2 non-steroidal anti-inflammatory drugs (NSAIDs) (coxibs) has been associated with an increased risk of acute myocardial infarction (AMI). However, the risk of AMI has only been studied for very few NSAIDs that are frequently used

Published
2018

50. A standardized flow cytometry network study for the assessment of circulating endothelial cell physiological ranges

Author

Lanuti, P, Simeone, P, Rotta, G, Almici, C, Avvisati, G, Azzaro, R, Bologna, G, Budillon, A, Di Cerbo, M, Di Gennaro, E, Di Martino, M, Diodato, A, Doretto, P, Ercolino, E, Falda, A, Gregorj, C, Leone, A, Losa, F, Malara, N, Marini, M, Mastroroberto, P, Mollace, V, Morelli, M, Muggianu, E, Musolino, G, Neva, A, Pierdomenico, L, Pinna, S, Piovani, G, Roca, M, Russo, D, Scotti, L, Tirindelli, M, Trunzo, V, Venturella, R, Vitagliano, C, Zullo, F, Marchisio, M, Miscia, S, Lanuti, Paola, Simeone, Pasquale, Rotta, Gianluca, Almici, Camillo, Avvisati, Giuseppe, Azzaro, Rosa, Bologna, Giuseppina, Budillon, Alfredo, Di Cerbo, Melania, Di Gennaro, Elena, Di Martino, Maria Luisa, Diodato, Annamaria, Doretto, Paolo, Ercolino, Eva, Falda, Alessandra, Gregorj, Chiara, Leone, Alessandra, Losa, Francesca, Malara, Natalia, Marini, Mirella, Mastroroberto, Pasquale, Mollace, Vincenzo, Morelli, Michele, Muggianu, Emma, Musolino, Giuseppe, Neva, Arabella, Pierdomenico, Laura, Pinna, Silvia, Piovani, Giovanna, Roca, Maria Serena, Russo, Domenico, Scotti, Lorenza, Tirindelli, Maria Cristina, Trunzo, Valentina, Venturella, Roberta, Vitagliano, Carlo, Zullo, Fulvio, Marchisio, Marco, Miscia, Sebastiano, Lanuti, P, Simeone, P, Rotta, G, Almici, C, Avvisati, G, Azzaro, R, Bologna, G, Budillon, A, Di Cerbo, M, Di Gennaro, E, Di Martino, M, Diodato, A, Doretto, P, Ercolino, E, Falda, A, Gregorj, C, Leone, A, Losa, F, Malara, N, Marini, M, Mastroroberto, P, Mollace, V, Morelli, M, Muggianu, E, Musolino, G, Neva, A, Pierdomenico, L, Pinna, S, Piovani, G, Roca, M, Russo, D, Scotti, L, Tirindelli, M, Trunzo, V, Venturella, R, Vitagliano, C, Zullo, F, Marchisio, M, Miscia, S, Lanuti, Paola, Simeone, Pasquale, Rotta, Gianluca, Almici, Camillo, Avvisati, Giuseppe, Azzaro, Rosa, Bologna, Giuseppina, Budillon, Alfredo, Di Cerbo, Melania, Di Gennaro, Elena, Di Martino, Maria Luisa, Diodato, Annamaria, Doretto, Paolo, Ercolino, Eva, Falda, Alessandra, Gregorj, Chiara, Leone, Alessandra, Losa, Francesca, Malara, Natalia, Marini, Mirella, Mastroroberto, Pasquale, Mollace, Vincenzo, Morelli, Michele, Muggianu, Emma, Musolino, Giuseppe, Neva, Arabella, Pierdomenico, Laura, Pinna, Silvia, Piovani, Giovanna, Roca, Maria Serena, Russo, Domenico, Scotti, Lorenza, Tirindelli, Maria Cristina, Trunzo, Valentina, Venturella, Roberta, Vitagliano, Carlo, Zullo, Fulvio, Marchisio, Marco, and Miscia, Sebastiano

Abstract

Circulating endothelial cells (CEC) represent a restricted peripheral blood (PB) cell subpopulation with high potential diagnostic value in many endothelium-involving diseases. However, whereas the interest in CEC studies has grown, the standardization level of their detection has not. Here, we undertook the task to align CEC phenotypes and counts, by standardizing a novel flow cytometry approach, within a network of six laboratories. CEC were identified as alive/nucleated/CD45negative/CD34bright/CD146positive events and enumerated in 269 healthy PB samples. Standardization was demonstrated by the achievement of low inter-laboratory Coefficients of Variation (CVL), calculated on the basis of Median Fluorescence Intensity values of the most stable antigens that allowed CEC identification and count (CVL of CD34bright on CEC ∼ 30%; CVL of CD45 on Lymphocytes ∼ 20%). By aggregating data acquired from all sites, CEC numbers in the healthy population were captured (medianfemale = 9.31 CEC/mL; medianmale = 11.55 CEC/mL). CEC count biological variability and method specificity were finally assessed. Results, obtained on a large population of donors, demonstrate that the established procedure might be adopted as standardized method for CEC analysis in clinical and in research settings, providing a CEC physiological baseline range, useful as starting point for their clinical monitoring in endothelial dysfunctions.

Published
2018

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