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3. Safety, Efficacy and Persistence of Advanced Therapies in Inflammatory Bowel Disease: Results from ORIGINS. A Retrospective Observational Study

Author

Mateescu, Radu Bogdan, primary, Gheorghe, Cristian, primary, Trifan, Anca Victorita, primary, Saftoiu, Adrian, primary, Seicean, Andrada, primary, Diculescu, Mihai Mircea, primary, Banciu, Christian, primary, Gheorghe, Liliana Simona, primary, Busuioc, Bogdan, primary, Goldis, Adrian, primary, Dobru, Daniela, primary, Fratila, Ovidiu, primary, Eugen, Dumitru, primary, Bataga, Simona, primary, Constantinescu, Gabriel, primary, Gheonea, Dan, primary, Tantau, Alina, primary, Jinga, Mariana, primary, Brisc, Ciprian, primary, Cijevschi Prelipcean, Cristina, primary, Chira, Romeo, primary, Fierbințeanu-Braticevici, Carmen, primary, Dumitrascu, Dan, primary, State, Monica, primary, Voiosu, Theodor, primary, and Negreanu, Lucian, primary

Published
2023
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6. Unveiling Distinct Proteomic Signatures in Complicated Crohn's Disease That Could Predict the Disease Course.

Author

Lucaciu, Laura A., Seicean, Radu, Uifălean, Alina, Iacobescu, Maria, Iuga, Cristina A., and Seicean, Andrada

Subjects
CROHN'S disease, DISEASE progression, PROTEOMICS, INFLAMMATORY bowel diseases, INFLAMMATION
Abstract

Crohn's disease (CD) is characterized by a chronic, progressive inflammation of the gastrointestinal tract often leading to complications, such as strictures and fistulae. Currently, there are no validated tools anticipating short- and long-term outcomes at an early stage. This investigation aims to elucidate variations in protein abundance across distinct CD phenotypes with the objective of uncovering potential biomarkers implicated in disease advancement. Serum samples collected from 30 CD patients and 15 healthy age-matched controls (HC) were subjected to depletion of highly abundant proteins and to a label-free mass spectrometry analysis. Twenty-four proteins were shown to be significantly different when comparing CD with HC. Of these, WD repeat-containing protein 31 (WDR31), and proteins involved in the acute inflammatory response, leucine-rich alpha-2-glycoprotein (LRG1) and serum amyloid A1 (SAA1), were more abundant in the aggressive subgroup. Against standard biomarkers, a positive correlation between SAA1 and WDR31 and C-reactive protein (CRP) was found. In this study, a unique serum biomarker panel for aggressive CD was identified, which could aid in predicting the disease course. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Romanian Guidelines for the Diagnosis and Treatment of GERD-induced Respiratory Manifestations

Author

Drug, Vasile Liviu, primary, Antoniu, Sabina, primary, Oana, Barboi Bogdana, primary, Arghir, Oana Cristina, primary, Bancila, Ion, primary, Bataga, Simona, primary, Brisc, Ciprian, primary, Cijevschi-Prelipcean, Cristina, primary, Ciocîrlan, Mihai, primary, Ciortescu, Irina, primary, David, Liliana, primary, Deleanu, Oana Claudia, primary, Diculescu, Mircea, primary, Dimitriu, Anca, primary, Dobru, Daniela, primary, Dumitru, Eugen, primary, Gheonea, Dan Ionut, primary, Gheorghe, Cristian, primary, Goldis, Adrian, primary, Jinga, Mariana, primary, Man, Milena, primary, Mateescu, Bogdan, primary, Manuc, Mircea, primary, Mihai, Catalina, primary, Mihaltan, Florin, primary, Mihaescu, Traian, primary, Nedelcu, Laurentiu, primary, Negreanu, Lucian, primary, Pop, Carmen Monica, primary, Rajnoveanu, Ruxandra, primary, Saftoiu, Adrian, primary, Seicean, Andrada, primary, Sporea, Ioan, primary, Stanciu, Carol, primary, Surdea-Blaga, Teodora, primary, Tantau, Marcel, primary, Todea, Doina, primary, Trifan, Anca Victorita, primary, Ulmeanu, Ruxandra, primary, Iov, Diana Elena, primary, and Dumitrascu, Dan Lucian, primary

Published
2022
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16. Common bile duct size in malignant distal obstruction and lumen-apposing metal stents: a multicenter prospective study

Author

Rimbaş, Mihai, additional, Anderloni, Andrea, additional, Napoléon, Bertrand, additional, Seicean, Andrada, additional, Forti, Edoardo, additional, Crinò, Stefano Francesco, additional, Tarantino, Ilaria, additional, Arcidiacono, Paolo Giorgio, additional, Fabbri, Carlo, additional, Rizzatti, Gianenrico, additional, Amato, Arnaldo, additional, Voiosu, Theodor, additional, Fugazza, Alessandro, additional, Moșteanu, Ofelia, additional, Ginès, Àngels, additional, de Nucci, Germana, additional, Fusaroli, Pietro, additional, Nguyen, Nam Quoc, additional, Di Mitri, Roberto, additional, Minelli Grazioli, Leonardo, additional, Mutignani, Massimiliano, additional, Archibugi, Livia, additional, Binda, Cecilia, additional, Cominardi, Anna, additional, Barbera, Carmelo, additional, Fernández-Esparrach, Glòria, additional, Palazzo, Laurent, additional, Palazzo, Maxime, additional, Poley, Jan Werner, additional, Spada, Cristiano, additional, Valerii, Giorgio, additional, Itoi, Takao, additional, Matsunami, Yukitoshi, additional, Mateescu, Radu Bogdan, additional, Băicuș, Cristian, additional, Costamagna, Guido, additional, and Larghi, Alberto, additional

Published
2021
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17. Performance of a new flexible 19 G EUS needle in pancreatic solid lesions located in the head and uncinate process: A prospective multicenter study

Author

Ginès, Angels, additional, Fusaroli, Pietro, additional, Sendino, Oriol, additional, Seicean, Andrada, additional, Gimeno-Garcia, Antonio Z., additional, Gratacós-Ginès, Jordi, additional, Araujo, Isis K., additional, Rodríguez-Carunchio, Leonardo, additional, Alós, Silvia, additional, Lisotti, Andrea, additional, Cominardi, Anna, additional, Montenegro, Andrea, additional, and Fernández-Esparrach, Glòria, additional

Published
2021
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18. Romanian Guidelines for Nonpharmacological Therapy of IBS

Author

Dumitrascu, Dan L., primary, Baban, Adriana, primary, Bancila, Ion, primary, Barboi, Oana, primary, Bataga, Simona, primary, Chira, Alexandra, primary, Chirila, Ioan, primary, Cijevschi Prelipcean, Cristina, primary, Ciobanu, Lidia, primary, Cozma-Petrut, Anamaria, primary, David, Liliana, primary, Diculescu, Mircea, primary, Dobru, Daniela, primary, Dimitriu, Anca, primary, Dumitru, Eugen, primary, Fadgyas-Stanculete, Mihaela, primary, Gheorghe, Cristian, primary, Gilca-Blanariu, Georgiana-Emmanuela, primary, Goldis, Adrian, primary, Grad, Simona, primary, Macarie, Melania, primary, Marica-Sabo, Cristina, primary, Miere, Doina, primary, Nedelcu, Laurentiu, primary, Negovan, Anca, primary, Pojoga, Cristina, primary, Pop, Andrei Vasile, primary, Popa, Stefan-Lucian, primary, Porr, Paul Juergen, primary, Rusu, Flaviu, primary, Seicean, Andrada, primary, Sporea, Ioan, primary, Stroie, Tudor, primary, Blaga-Surdea, Teodora, primary, Tocia, Cristina, primary, Trifan, Anca, primary, Brisc, Ciprian, primary, and Drug, Vasile, primary

Published
2021
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20. What is the Impact of the Proportion of Solid Necrotic Content on the Number of Necrosectomies during EUS-Guided Drainage using Lumen-Apposing Metallic Stents of Pancreatic Walled-off Necrosis ?

Author

Seicean, Andrada, primary, Pojoga, Cristina, primary, Mostean, Ofelia, primary, Bolboaca, Sorana, primary, Ilie, Madalina, primary, Rimbas, Mihai, primary, Gheorghiu, Marcel, primary, Lucaciu, Laura, primary, Bartos, Adrian, primary, Al Hajjar, Nadim, primary, Sandru, Vasile, primary, Constantinescu, Gabriel, primary, and Seicean, Radu, primary

Published
2020
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22. SRED-ARCE Recommendations for Minimally Invasive Interventions During the COVID-19 Pandemic in Romania

Author

Saftoiu, Adrian, primary, Tomulescu, Victor, primary, Tantau, Marcel, primary, Gheorghe, Cristian, primary, Dumitru, Eugen, primary, Mateescu, Bogdan, primary, Negreanu, Lucian, primary, Jinga, Mariana, primary, Seicean, Andrada, primary, Ciocirlan, Mihai, primary, Drug, Vasile, primary, Manuc, Mircea, primary, Popescu, Razvan, primary, Tiu, Calin, primary, Bintintan, Vasile, primary, Calu, Valentin, primary, Turlin, Valeriu, primary, Turcu, Florin, primary, Zaharie, Florin, primary, Ulmeanu, Dan, primary, Brebu, Dan, primary, Nicolau, Alexandru, primary, Litescu, Mircea, primary, Diaconescu, Bogdan, primary, Duta, Ciprian, primary, and Copaescu, Catalin, primary

Published
2020
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24. Percutaneous Endoscopic Gastrostomy with Jejunal Extension Tube for the Delivery of Levodopa Carbidopa Intestinal Gel: Clinical Practice Guidelines of the Romanian Society of Digestive Endoscopy

Author

Gheorghe, Cristian, primary, Dumitru, Eugen, primary, Ciocîrlan, Mihai, primary, Dobru, Daniela, primary, Drug, Vasile, primary, Goldis, Adrian, primary, Jinga, Mariana, primary, Manuc, Mircea, primary, Saftoiu, Adrian, primary, Seicean, Andrada, primary, Cotruta, Bogdan, primary, Bancila, Ion, primary, Pitigoi, Dan, primary, Mercea, Voicu Alexandru, primary, and Tanțău, Marcel, primary

Published
2019
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26. Changes in tumor vascularity depicted by contrast-enhanced EUS as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE): A study protocol

Author

Cazacu, IrinaM, primary, Sãftoiu, Adrian, additional, Bhutani, ManoopS, additional, Itoi, Takao, additional, Arcidiacono, PaoloG, additional, Bories, Erwan, additional, Constantin, Alina, additional, Coronel, Emmanuel, additional, Dietrich, ChristophF, additional, Duda, DanG, additional, Garcia, JulioIglesias, additional, Hocke, Michael, additional, Ignee, Andre, additional, Jenssen, Christian, additional, Jinga, Mariana, additional, Khor, Christopher, additional, Oppong, KofiW, additional, Pereira, Stephen, additional, Petrone, MariaChiara, additional, Santo, Erwin, additional, Seicean, Andrada, additional, Seo, DongWan, additional, Siyu, Sun, additional, Vilmann, Peter, additional, Waxman, Irving, additional, and Yeaton, Paul, additional

Published
2019
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28. Variceal bleeding in cirrhotic patients: risk factors, evolution, treatment

Author

ROMCEA, ANCA, TANŢĂU, MARCEL, SEICEAN, ANDRADA, and PASCU, OLIVIU

Subjects
cirrhosis, bleeding relapse, Gastroenterology, sclerotherapy, variceal bleeding, elastic ligatures, Original Research
Abstract

Objectives The aim of this study was to monitor the risk factors that trigger variceal bleeding in cirrhotic patients, assess the severity of the bleeding and the efficacy of the endoscopic hemostasis techniques, as well as the recurrence of bleeding episodes and the mortality rate. Materials and Methods The current study was a prospective one, and it was conducted in the period November 2004 - December 2006 in the “O. Fodor” Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca. It included 273 patients with upper gastrointestinal bleeding because of variceal rupture, assessed by emergency endoscopy. The patients included in the study met the clinical, biochemical, endoscopic and ultrasound criteria for liver cirrhosis. Its etiology and staging were documented from the patients’ observation charts. Results Out of the 273 cases of variceal bleeding there were 255 (93.4%) cases of bleeding from esophageal varices and 18 (6.6%) from gastric varices. Variceal bleeding episodes were more frequent in patients with alcoholic liver cirrhosis (51.28%). Most patients with variceal bleeding were in Child class B or C (77%). Mortality because of variceal hemorrhage was 2.93% in the study group. A number of 148 patients were treated by sclerotherapy and 125 patients with elastic ligatures. Bleeding relapses occurred in 65 (23.8%) patients within the study group, 43 men and 22 women. Variceal bleeding relapses were more frequent after sclerotherapy than after elastic ligatures. Conclusions Variceal bleeding occurred more frequently in patients with alcoholic cirrhosis stage Child C. In the current study mortality was relatively low. The treatment of bleeding recurrence is more difficult, hence variceal rupture prevention and application of elastic ligatures represent a therapeutic necessity.

Published
2013

29. Predictors of Liver Stiffness Regression after SVR in Cirrhotic Patients Treated with 3D Regimen

Author

Iacob, Speranta, primary, Gheorghe, Liliana, additional, Prelipcean, Cristina Cijevschi, additional, Trifan, Anca, additional, Stanciu, Carol, additional, Sporea, Ioan, additional, Sirli, Roxana, additional, Curescu, Manuela, additional, Brisc, Ciprian, additional, Mihai, Catalina, additional, Alexandrescu, Luana, additional, Sandulescu, Larisa D., additional, Goldis, Adrian, additional, Arama, Victoria, additional, Caruntu, Florin, additional, Hara, Livia, additional, Rogoveanu, Ion, additional, Diculescu, Mircea, additional, Iacob, Razvan, additional, Gheorghe, Cristian, additional, Seicean, Andrada, additional, Simionov, Iulia I., additional, Vadan, Roxana, additional, Pirvulescu, Iuliana, additional, and Pietrareanu, Corina, additional

Published
2017
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30. Prospective Analysis of Discordant Results Between Fibromax® and Fibroscan® in Patients with HCV Compensated Liver Cirrhosis before 3D Antiviral Therapy Initiation

Author

Gheorghe, Liliana, primary, Iacob, Speranta, additional, Prelipcean, Cristina Cijevschi, additional, Trifan, Anca, additional, Stanciu, Carol, additional, Sporea, Ioan, additional, Sirli, Roxana, additional, Curescu, Manuela, additional, Brisc, Ciprian, additional, Mihai, Catalina, additional, Alexandrescu, Luana, additional, Sandulescu, Larisa D., additional, Goldis, Adrian, additional, Arama, Victoria, additional, Caruntu, Florin, additional, Hara, Livia, additional, Rogoveanu, Ion, additional, Diculescu, Mircea, additional, Gheorghe, Cristian, additional, Seicean, Andrada, additional, Iacob, Razvan, additional, Simionov, Iulia I., additional, Vadan, Roxana, additional, Pirvulescu, Iuliana, additional, and Pietrareanu, Corina, additional

Published
2017
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33. Endoscopic therapy in chronic pancreatitis: current perspectives

Author

Seicean, Andrada and Vultur,Simona

Subjects
Clinical and Experimental Gastroenterology, digestive system diseases
Abstract

Andrada Seicean, Simona Vultur Regional Institute of Gastroenterology and Hepatology Cluj-Napoca, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania Abstract: Endoscopic therapy in chronic pancreatitis (CP) aims to provide pain relief and to treat local complications, by using the decompression of the pancreatic duct and the drainage of pseudocysts and biliary strictures, respectively. This is the reason for using it as first-line therapy for painful uncomplicated CP. The clinical response has to be evaluated at 6–8 weeks, when surgery may be chosen. This article reviews the main possibilities of endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) therapies. Endotherapy for pancreatic ductal stones uses ultrasound wave lithotripsy and sometimes additional stone extractions. The treatment of pancreatic duct strictures consists of a single large stenting for 1 year. If the stricture persists, simultaneous multiple stents are applied. In case of unsuccessful ERCP, the EUS-guided drainage of the main pancreatic duct (MPD) or a rendezvous technique can solve the ductal strictures. EUS-guided celiac plexus block has limited efficiency in CP. The drainage of symptomatic or complicated pancreatic pseudocysts can be performed transpapillarily or transgastrically/transduodenally, preferably by EUS guidance. When the biliary stricture is symptomatic or progressive, multiple plastic stents are indicated. In conclusion, as in many fields of symptomatic treatment, endoscopy remains the first choice, either by using ERCP or EUS-guided procedures, after consideration of a multidisciplinary team with endoscopists, surgeons, and radiologists. However, what is crucial is establishing the right timing for surgery. Keywords: chronic pancreatitis, treatment, endoscopy, ERCP, endoscopic ultrasound

Published
2014

34. The etiology of upper gastrointestinal bleeding in cirrhotic patients

Author

ROMCEA, ANCA ALEXANDRA, TANŢĂU, MARCEL, SEICEAN, ANDRADA, and PASCU, OLIVIU

Subjects
cirrhosis, Gastroenterology, non-variceal upper gastrointestinal hemorrhage, variceal bleeding, Original Research
Abstract

Aims To investigate the etiology of upper digestive hemorrhage in cirrhotic patients. Patients and methods From November 2004 to December 2006, we performed a prospective study at the Regional Institute of Gastroenterology and Hepatology “O. Fodor” Cluj-Napoca. The study was performed on 1,284 patients with esophageal varices from the endoscopy records, diagnosed with liver cirrhosis based on clinical, biochemical and endoscopic information, documented from the observation sheet. During the periodical examinations, we observed and monitored the patients’ variceal and non-variceal bleedings. Results Out of the 1,284 patients included in this study, there were 297 cases of upper digestive hemorrhage, the dominant etiology being the variceal bleeding (217 cases - 73%), and 80 (27%) cases of upper non-variceal digestive hemorrhage. Duodenal ulcer was the main cause for upper non-variceal digestive hemorrhage in case of cirrhotic patients considered for this study (33.75%), followed by gastric ulcer (21.25%), portal hypertensive gastropathy (17.5%), acute erosive gastritis (11.25%), Mallory-Weiss syndrome (6.25%), esophageal ulcer (5%), antral vascular ectasia (1.25%), duodenal polyps (1.25%) and exulcerated gastric tumor (1.25%). We also observed the cases of hemorrhagic relapse in the group of patients with variceal hemorrhages. Variceal bleedings are predominant in each Child-Pugh clinical category, but one must mention that the risk of variceal rupture increases with the severity of the hepatic disease. There were 8 deaths, all caused by esophageal variceal hemorrhages. Conclusions In our study, almost 27% of cirrhotic patients with upper gastrointestinal hemorrhage had bleeding from a non-variceal source, the most common etiology being peptic ulcer. Variceal bleeding is more severe and bears a higher mortality rate than non-variceal bleeding.

Published
2013

39. Romanian Guidelines on the Diagnosis and Treatment of Exocrine Pancreatic Insufficiency

Author

Gheorghe, Cristian, primary, Seicean, Andrada, primary, Saftoiu, Adrian, primary, Tantau, Marcel, primary, Dumitru, Eugen, primary, Jinga, Mariana, primary, Negreanu, Lucian, primary, Mateescu, Bogdan, primary, Gheorghe, Liana, primary, Ciocirlan, Mihai, primary, Cijevschi, Cristina, primary, Constantinescu, Gabriel, primary, Dima, Simona, primary, and Diculescu, Mircea, primary

Published
2015
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41. Sa1540 - Prospective Analysis of Discordant Results Between Fibromax® and Fibroscan® in Patients with HCV Compensated Liver Cirrhosis before 3D Antiviral Therapy Initiation

Author

Gheorghe, Liliana, Iacob, Speranta, Prelipcean, Cristina Cijevschi, Trifan, Anca, Stanciu, Carol, Sporea, Ioan, Sirli, Roxana, Curescu, Manuela, Brisc, Ciprian, Mihai, Catalina, Alexandrescu, Luana, Sandulescu, Larisa D., Goldis, Adrian, Arama, Victoria, Caruntu, Florin, Hara, Livia, Rogoveanu, Ion, Diculescu, Mircea, Gheorghe, Cristian, Seicean, Andrada, Iacob, Razvan, Simionov, Iulia I., Vadan, Roxana, Pirvulescu, Iuliana, and Pietrareanu, Corina

Published
2017
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42. Tu1544 - Predictors of Liver Stiffness Regression after SVR in Cirrhotic Patients Treated with 3D Regimen

Author

Iacob, Speranta, Gheorghe, Liliana, Prelipcean, Cristina Cijevschi, Trifan, Anca, Stanciu, Carol, Sporea, Ioan, Sirli, Roxana, Curescu, Manuela, Brisc, Ciprian, Mihai, Catalina, Alexandrescu, Luana, Sandulescu, Larisa D., Goldis, Adrian, Arama, Victoria, Caruntu, Florin, Hara, Livia, Rogoveanu, Ion, Diculescu, Mircea, Iacob, Razvan, Gheorghe, Cristian, Seicean, Andrada, Simionov, Iulia I., Vadan, Roxana, Pirvulescu, Iuliana, and Pietrareanu, Corina

Published
2017
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