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1. Total Synthesis and Antibacterial Activities of Four Natural Dual Prenylated Flavonoids

Author

Bingbing Chen, Yao Feng, Jin Hui Yang, Shangbiao Feng, Wubiao Zuo, Xiaoqin Ma, and Yimin Xie

Subjects
Prenylation, biology, Stereochemistry, Chemistry, Organic Chemistry, Proton NMR, Total synthesis, Organic chemistry, Carbon-13 NMR, Study Completed, biology.organism_classification, Erythrina
Abstract

Abyssinone-V, 4'-hydroxy-6,3',5'-triprenylisoflavonone, abyssinone-VI and abyssinone-IV were all isolated from the genus erythrina. This study completed the first total synthesis of four natural prenylated flavanoids by using simple and facile approaches. The result of their in vitro antibacterial tests indicated that all of them displayed moderate bacteriostatic activities. The compounds abyssinone-IV and abyssinone-V showed remarkable antibacterial activities. The structures of all new compounds have been confirmed by HRMS, 1 H NMR and 13 C NMR spectra.

Published
2013

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