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23 results on '"Shu, Xiaochen"'

7. Comparing Long-Term Survival Outcomes for Muscle-Invasive Bladder Cancer Patients Who Underwent with Radical Cystectomy and Bladder-Sparing Trimodality Therapy: A Multicentre Cohort Analysis

Author

Qiu, Junlan, primary, Zhang, Haifeng, additional, Xu, Dongkui, additional, Li, Lin, additional, Xu, Lingkai, additional, Jiang, Yiqing, additional, Wen, Tao, additional, Lu, Shun, additional, Meng, Fang, additional, Feng, Lin, additional, and Shu, Xiaochen, additional

Published
2022
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8. Clinical Significance of Serum IgM and IgG levels in COVID-19 patients in Hubei Province, China

Author

Bai, Zhenjiang, primary, Li, Qing, additional, Chen, Qinghui, additional, Niu, Changming, additional, Wei, Yu, additional, Huang, Hanpeng, additional, Zhao, Wei, additional, Chen, Nian, additional, Yao, Xin, additional, Zhang, Qiang, additional, Mu, Chuanyong, additional, Feng, Jian, additional, Zhu, Chuanlong, additional, Li, Zhuo, additional, Ding, Ming, additional, Feng, Binhui, additional, Jin, Chaochao, additional, Lu, Xiang, additional, Yang, Yi, additional, Wu, Shuiyan, additional, Shu, Xiaochen, additional, Hu, Lifang, additional, Qiu, Haibo, additional, and Huang, YingZi, additional

Published
2021
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18. Prenatal and Postnatal Medical Conditions and the Risk of Brain Tumors in Children and Adolescents: An International Multicenter Case–Control Study

Author

Tettamanti, Giorgio, primary, Shu, Xiaochen, additional, Adel Fahmideh, Maral, additional, Schüz, Joachim, additional, Röösli, Martin, additional, Tynes, Tore, additional, Grotzer, Michael, additional, Johansen, Christoffer, additional, Klaeboe, Lars, additional, Kuehni, Claudia E., additional, Lannering, Birgitta, additional, Schmidt, Lisbeth S., additional, Vienneau, Danielle, additional, and Feychting, Maria, additional

Published
2017
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19. Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations

Author

Balram Chowbay, Suman Lal, Liu Yan Yan, Xiang Xiaoqiang, Shu Xiaochen, Srinivasa Rao Jada, Shu-Feng Zhou, and London L.P.J. Ooi

Subjects
Male, China, Genotype, Population, India, Organic Anion Transporters, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Asian People, Gene Frequency, Polymorphism (computer science), Humans, Pharmacology (medical), education, Allele frequency, Genetics, Pharmacology, Singapore, education.field_of_study, biology, Liver-Specific Organic Anion Transporter 1, Haplotype, Malaysia, General Medicine, Haplotypes, Liver, biology.protein, SLCO1B1, Pharmacogenetics
Abstract

The aim of this study was to characterize the population frequency of SLCO1B1 polymorphic variants in three distinct healthy Asian populations, namely Chinese (n = 100), Malay (n = 100) and Indian (n = 100), and to explore the association between haplotype-tagged single nucleotide polymorphisms (htSNPs) on hepatic SLCO1B1 mRNA expression.The distribution of polymorphic variants in the SLCO1B1 gene at eight loci that spanned approximately 48 kb was investigated in the three different Asian ethnic groups and in 32 non-cancerous liver tissues from Chinese patients.Of the 26 polymorphisms screened, we found eight polymorphic variants that differed in genotypic and allelic frequencies between the Chinese, Malay and Indian populations. Significant interethnic differences were observed in the genotype frequency distributions across the promoter SNP [g.-11187GA (P = 0.030)] as well as three coding region SNPs [c.388GA (P0.001); c.571TC (P0.001); c.597CT (P0.001)] in the healthy subjects. Haplotype analysis revealed 12 different haplotypes in both the Chinese and Malay populations and 18 haplotypes in the Indian population. In both the Malay and Indian populations, the htSNPs were c.388AG, c.571TC and c.597CT, whereas in the Chinese population they were g.-11187GA, c.388AG and c.597CT. The c.388AG and c.597CT htSNPs accounted for more than 70% of the variations between the three major haplotypes in each Asian ethnic group. In terms of the c.388AG htSNPs, genotypic-phenotypic association analyses revealed that there was no effect on SLCO1B1 expression in hepatic tissues; in addition, no genotypic-phenotypic associations were evident with regards to the c.597CT htSNP.Future studies should investigate the phenotypic effects of the c.388AG htSNP on the disposition of OATP1B1 substrates in Asian populations.

Published
2007

20. Treatment of adolescent patients with class II division 1 malocclusion using Eruption guidance appliance: A comparative study with Twin-block and Activator-Headgear appliances.

Author

Nilsson, Jenny Jiayan Luo, Shu, Xiaochen, Magnusson, Britt Hedenberg, and Burt, Idil Alatli

Subjects
TREATMENT of malocclusion, COMPARATIVE studies, RESEARCH methodology, MEDICAL cooperation, ORTHODONTIC appliances, PATIENT compliance, RESEARCH, EVALUATION research
Abstract

The aim of this study was to evaluate the compliance and short-term effects of eruption guidance appliance (EGA) in adolescents with class II division 1 malocclusion in comparison with twin-block appliance (TBA) and activator-headgear appliance (A-HG). Dental records of 1886 patients were viewed in this retrospective study 129 patients treated with one of these three functional appliances were identified. 123 fulfilled the inclusion criteria and data were extracted from the dental records. Gender, age, compliance, overjet change at every visit, number of appliance breakages and number of emergency visits apart from appliance breakage were studied. The data were analyzed with Chi-square test, General Linear Model and Fisher scoring test. Results showed that 47 patients were treated with EGA, 38 patients with TBA and 38 patients with A-HG. Mean ages starting the treatment were slightly lower with EGA (11.5 years) than with TBA (12.3 years) and A-HG (11.8 years). Non-compliance was higher in the EGA group (31.9%) than TBA group (26.3%) and A-HG group (23.7%). Mean overjet reduction per month was 0.6 mm for EGA which was lower than TBA group (0.7 mm) and A-HG groups (0.7 mm).The number of emergency visits and appliance breakage were lower in EGA group. However, there was no statistically significant difference between the 3 groups regarding ages,compliance, mean overjet reduction, emergency visits and appliance breakage aspects. In conclusion, this study indicates that EGA is an alternative choice in the treatment of adolescent patients with class II division 1 malocclusion. However, long-term follow-up and cephalometric prospective study should be performed to continue our understanding more about the mechanisms of EGA and more definite conclusions can be made. [ABSTRACT FROM AUTHOR]

Published
2016

23. Cancer Epidemiology in China: What We Have Learnt So Far?

Author

Ji, Jianguang, Chen, Tianhui, Ji, Jianguang, Liu, Hao, and Shu, Xiaochen

Subjects
Medicine, Oncology, China, cancer burden in China, cancer epidemiology, cancer mortality, public health
Abstract

Summary: After several decades of development, the socialist market economy of China is now the world's second largest economy by nominal GDP. China is also the largest economy by purchasing power parity according to the International Monetary Fund. In tandem with the development of the Chinese economy, China's cancer burden is rising rapidly due to an ageing population and the adoption of unhealthy lifestyle behaviours. According to the data from the National Central Cancer Registry (NCCR) of China, the incidence and mortality of cancer have been increasing rapidly in China. In recent years, cancer has been the leading cause of death among city residents and the second cause of death among rural residents, which has become a stark public health issue in China. According to the NCCR, an estimated 4.29 million new incident cases (12 thousand per day) and 2.81 million death cases (7.5 thousand per day) would occur in 2015 in China. This corresponds to the age-standardized incidence rate (ASIR) of 201.1 per 100,000 and age-standardized mortality rate (ASMR) of 126.9 per 100,000, respectively. Due to the geographical and ethnical disparities in living habits and healthcare level, the cancer spectrum differs between different regions and ethnical groups in China. According to the estimation from IARC, the incidence of nasopharyngeal carcinoma and liver cancer is the world's highest in specific regions of China. The incidence of some cancer types in Chinese urban areas, such as colorectal, prostate, kidney and bladder cancers, is similar to that in developed countries or regions where the incidence of cancer is highly associated with obesity and westernised lifestyles. Nevertheless, the incidence of some common cancer types in rural areas, including oesophageal, stomach, liver and cervical cancers, shares similarity with less developed countries or regions in the world where cancers are associated with chronic infectious agents due to poverty. In addition, the mortality rate is higher in rural areas, which suggests a poorer cancer prognosis due to late diagnosis and/or unsatisfying clinical treatment. The distinct cancer patterns of different regions and/or ethnic groups indicate a need for precise cancer prevention and control plans tailored for different geographical regions and/or ethnic groups. The overarching goal of the proposed Frontiers in Oncology Research Topic is to present current perspectives on cancer epidemiology in Chinese characteristics and provide current knowledge of cancer burden as well as cancer mortality to academic investigators, clinicians and stakeholders from the translational, clinical and public health communities.

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