14 results on '"Skotadis, E."'
Search Results
2. Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors
- Author
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Kaloumenou, M. Skotadis, E. Lagopati, N. Efstathopoulos, E. Tsoukalas, D.
- Abstract
Early-stage disease diagnosis is of particular importance for effective patient identification as well as their treatment. Lack of patient compliance for the existing diagnostic methods, however, limits prompt diagnosis, rendering the development of non-invasive diagnostic tools mandatory. One of the most promising non-invasive diagnostic methods that has also attracted great research interest during the last years is breath analysis; the method detects gas-analytes such as exhaled volatile organic compounds (VOCs) and inorganic gases that are considered to be important biomarkers for various disease-types. The diagnostic ability of gas-pattern detection using analytical techniques and especially sensors has been widely discussed in the literature; however, the incorporation of novel nanomaterials in sensor-development has also proved to enhance sensor performance, for both selective and cross-reactive applications. The aim of the first part of this review is to provide an up-to-date overview of the main categories of sensors studied for disease diagnosis applications via the detection of exhaled gas-analytes and to highlight the role of nanomaterials. The second and most novel part of this review concentrates on the remarkable applicability of breath analysis in differential diagnosis, phenotyping, and the staging of several disease-types, which are currently amongst the most pressing challenges in the field. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
- Published
- 2022
3. PHEMA functionalized gold nanoparticle films for vapor sensing
- Author
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Tang, Jun, Skotadis, E., Tsouti, V., and Tsoukalas, D.
- Published
- 2010
- Full Text
- View/download PDF
4. Platinum Nanoparticle Chemical Sensors on Polyimide Substrates
- Author
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Skotadis, E., primary, Mousadakos, D., additional, Katsabrokou, K., additional, Stathopoulos, S., additional, and Tsoukalas, D., additional
- Published
- 2012
- Full Text
- View/download PDF
5. Chemi-resistive sensors based on platinum nanoparticle arrays
- Author
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Tanner, J.L., primary, Skotadis, E., additional, Stathopoulos, S., additional, Tsouti, V., additional, and Tsoukalas, D., additional
- Published
- 2011
- Full Text
- View/download PDF
6. Chemi-resistive sensors based on platinum nanoparticle arrays.
- Author
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Tanner, J.L., Skotadis, E., Stathopoulos, S., Tsouti, V., and Tsoukalas, D.
- Abstract
Abstract: The design and implementation of a chemi-resistor sensor utilizing platinum nanoparticles and a poly(2-hydroxyethyl methacrylate) (PHEMA) polymer layer is presented. The sensor was fabricated utilizing a magnetron sputtering system for the gas phase synthesis of metallic nanoparticles and an ink-jet printer for the PHEMA polymer delivery. The platinum nanoparticles have been deposited on oxidized silicon substrates which have been previously patterned with gold interdigitated electrodes. Following the nanoparticles deposition a PHEMA polymer layer has been delivered on top, using the ink-jet printing technique. By controlling the density of the metal nanoparticle film, sensors of different sensitivity can be fabricated. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
7. Non-Faradaic Impedimetric Detection of Heavy Metal Ions via a Hybrid Nanoparticle-DNAzyme Biosensor.
- Author
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Panagopoulou C, Skotadis E, Aslanidis E, Tzourmana G, Rapesi A, Tsioustas C, Kainourgiaki M, Kleitsiotis G, Tsekenis G, and Tsoukalas D
- Subjects
- Metal Nanoparticles chemistry, Platinum chemistry, Ions, Chromium analysis, Lead analysis, Nanoparticles chemistry, Electrochemical Techniques, Biosensing Techniques, DNA, Catalytic chemistry, Metals, Heavy analysis, Dielectric Spectroscopy
- Abstract
Due to rapid industrialization, novel water-quality monitoring techniques for the detection of highly toxic and hazardous heavy metal ions are essential. Herein, a hybrid noble nanoparticle/DNAzyme electrochemical biosensor is proposed for the simultaneous and label-free detection of Pb
2+ and Cr3+ in aqueous solutions. The sensor is based on the combination of a two-dimensional naked-platinum nanoparticle film and DNAzymes, whose double-helix configuration disassembles into smaller fragments in the presence of target-specific heavy metal ions. The electrochemical behavior of the fabricated sensor was investigated with non-faradaic electrochemical impedance spectroscopy (EIS), resulting in the successful detection of Pb2+ and Cr3+ well below their maximum permitted levels in tap water. So far, there has been no report on the successful detection of heavy metal ions utilizing the non-faradaic electrochemical impedance spectroscopy technique based on advanced nanomaterials paired with DNAzymes. This is also one of the few reports on the successful detection of chromium (III) via a sensor incorporating DNAzymes.- Published
- 2024
- Full Text
- View/download PDF
8. Vibration Sensors on Flexible Substrates Based on Nanoparticle Films Grown by Physical Vapor Deposition.
- Author
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Aslanidis E, Sarigiannidis S, Skotadis E, and Tsoukalas D
- Abstract
Flexible electronics have gained a lot of attention in recent years due to their compatibility with soft robotics, artificial arms, and many other applications. Meanwhile, the detection of acoustic frequencies is a very useful tool for applications ranging from voice recognition to machine condition monitoring. In this work, the dynamic response of Pt nanoparticles (Pt NPs)-based strain sensors on flexible substrates is investigated. the nanoparticles were grown in a vacuum by magnetron-sputtering inert-gas condensation. Nanoparticle sensors made on cracked alumina deposited by atomic layer deposition on the flexible substrate and reference nanoparticle sensors, without the alumina layer, were first characterized by their response to strain. The sensors were then characterized by their dynamic response to acoustic frequency vibrations between 20 Hz and 6250 Hz. The results show that alumina sensors outperformed the reference sensors in terms of voltage amplitude. Sensors on the alumina layer could accurately detect frequencies up to 6250 Hz, compared with the reference sensors, which were sensitive to frequencies up to 4250 Hz, while they could distinguish between two neighboring frequencies with a difference of no more than 2 Hz.
- Published
- 2024
- Full Text
- View/download PDF
9. Hybrid Nanoparticle/DNAzyme Electrochemical Biosensor for the Detection of Divalent Heavy Metal Ions and Cr 3 .
- Author
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Skotadis E, Aslanidis E, Tsekenis G, Panagopoulou C, Rapesi A, Tzourmana G, Kennou S, Ladas S, Zeniou A, and Tsoukalas D
- Abstract
A hybrid noble nanoparticle/DNAzyme electrochemical biosensor is proposed for the detection of Pb
2+ , Cd2+ , and Cr3+ . The sensor takes advantage of a well-studied material that is known for its selective interaction with heavy metal ions (i.e., DNAzymes), which is combined with metallic nanoparticles. The double-helix structure of DNAzymes is known to dissociate into smaller fragments in the presence of specific heavy metal ions; this results in a measurable change in device resistance due to the collapse of conductive inter-nanoparticle DNAzyme bridging. The paper discusses the effect of DNAzyme anchoring groups (i.e., thiol and amino functionalization groups) on device performance and reports on the successful detection of all three target ions in concentrations that are well below their maximum permitted levels in tap water. While the use of DNAzymes for the detection of lead in particular and, to some extent, cadmium has been studied extensively, this is one of the few reports on the successful detection of chromium (III) via a sensor incorporating DNAzymes. The sensor showed great potential for its future integration in autonomous and remote sensing systems due to its low power characteristics, simple and cost-effective fabrication, and easy automation and measurement.- Published
- 2023
- Full Text
- View/download PDF
10. Integrated Plastic Microfluidic Device for Heavy Metal Ion Detection.
- Author
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Filippidou MK, Kanaris AI, Aslanidis E, Rapesi A, Tsounidi D, Ntouskas S, Skotadis E, Tsekenis G, Tsoukalas D, Tserepi A, and Chatzandroulis S
- Abstract
The presence of heavy metal ions in soil, air and water constitutes an important global environmental threat, as these ions accumulate throughout the food chain, contributing to the rise of chronic diseases, including, amongst others, cancer and kidney failure. To date, many efforts have been made for their detection, but there is still a need for the development of sensitive, low-cost, and portable devices able to conduct on-site detection of heavy metal ions. In this work, we combine microfluidic technology and electrochemical sensing in a plastic chip for the selective detection of heavy metal ions utilizing DNAzymes immobilized in between platinum nanoparticles (PtNPs), demonstrating a reliable portable solution for water pollution monitoring. For the realization of the microfluidic-based heavy metal ion detection device, a fast and easy-to-implement fabrication method based on the photolithography of dry photosensitive layers is proposed. As a proof of concept, we demonstrate the detection of Pb
2+ ions using the prototype microfluidic device.- Published
- 2023
- Full Text
- View/download PDF
11. Breath Analysis: A Promising Tool for Disease Diagnosis-The Role of Sensors.
- Author
-
Kaloumenou M, Skotadis E, Lagopati N, Efstathopoulos E, and Tsoukalas D
- Subjects
- Breath Tests, Exhalation, Gases, Humans, Body Fluids, Volatile Organic Compounds
- Abstract
Early-stage disease diagnosis is of particular importance for effective patient identification as well as their treatment. Lack of patient compliance for the existing diagnostic methods, however, limits prompt diagnosis, rendering the development of non-invasive diagnostic tools mandatory. One of the most promising non-invasive diagnostic methods that has also attracted great research interest during the last years is breath analysis; the method detects gas-analytes such as exhaled volatile organic compounds (VOCs) and inorganic gases that are considered to be important biomarkers for various disease-types. The diagnostic ability of gas-pattern detection using analytical techniques and especially sensors has been widely discussed in the literature; however, the incorporation of novel nanomaterials in sensor-development has also proved to enhance sensor performance, for both selective and cross-reactive applications. The aim of the first part of this review is to provide an up-to-date overview of the main categories of sensors studied for disease diagnosis applications via the detection of exhaled gas-analytes and to highlight the role of nanomaterials. The second and most novel part of this review concentrates on the remarkable applicability of breath analysis in differential diagnosis, phenotyping, and the staging of several disease-types, which are currently amongst the most pressing challenges in the field.
- Published
- 2022
- Full Text
- View/download PDF
12. Identification of Two Commercial Pesticides by a Nanoparticle Gas-Sensing Array.
- Author
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Skotadis E, Kanaris A, Aslanidis E, Kalatzis N, Chatzipapadopoulos F, Marianos N, and Tsoukalas D
- Subjects
- Polymers, Temperature, Nanoparticles, Pesticides
- Abstract
This study presents the experimental testing of a gas-sensing array, for the detection of two commercially available pesticides (i.e., Chloract 48 EC and Nimrod), towards its eventual use along a commercial smart-farming system. The array is comprised of four distinctive sensing devices based on nanoparticles, each functionalized with a different gas-absorbing polymeric layer. As discussed herein, the sensing array is able to identify as well as quantify three gas-analytes, two pesticide solutions, and relative humidity, which acts as a reference analyte. All of the evaluation experiments were conducted in close to real-life conditions; specifically, the sensors response towards the three analytes was tested in three relative humidity backgrounds while the effect of temperature was also considered. The unique response patterns generated after the exposure of the sensing-array to the two gas-analytes were analyzed using the common statistical analysis tool Principal Component Analysis (PCA). The sensing array, being compact, low-cost, and highly sensitive, can be easily integrated with pre-existing crop-monitoring solutions. Given that there are limited reports for effective pesticide gas-sensing solutions, the proposed gas-sensing technology would significantly upgrade the added-value of the integrated system, providing it with unique advantages.
- Published
- 2021
- Full Text
- View/download PDF
13. Thin Film Protected Flexible Nanoparticle Strain Sensors: Experiments and Modeling.
- Author
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Aslanidis E, Skotadis E, Moutoulas E, and Tsoukalas D
- Abstract
In this work, the working performance of Platinum (Pt), solvent-free nanoparticle (NP)-based strain sensors made on a flexible substrate has been studied. First, a new model has been developed in order to explain sensor behaviour under strain in a more effective manner than what has been previously reported. The proposed model also highlights the difference between sensors based on solvent-free and solvent-based NPs. As a second step, the ability of atomic layer deposition (ALD) developed Al
2 O3 (alumina) thin films to act as protective coatings against humidity while in adverse conditions (i.e., variations in relative humidity and repeated mechanical stress) has been evaluated. Two different alumina thicknesses (5 and 11 nm) have been tested and their effect on protection against humidity is studied by monitoring sensor resistance. Even in the case of adverse working conditions and for increased mechanical strain (up to 1.2%), it is found that an alumina layer of 11 nm provides sufficient sensor protection, while the proposed model remains valid. This certifies the appropriateness of the proposed strain-sensing technology for demanding applications, such as e-skin and pressure or flow sensing, as well as the possibility of developing a comprehensive computational tool for NP-based devices., Competing Interests: The authors declare no conflict of interest.- Published
- 2020
- Full Text
- View/download PDF
14. Label-free DNA biosensor based on resistance change of platinum nanoparticles assemblies.
- Author
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Skotadis E, Voutyras K, Chatzipetrou M, Tsekenis G, Patsiouras L, Madianos L, Chatzandroulis S, Zergioti I, and Tsoukalas D
- Subjects
- Base Pair Mismatch, Biosensing Techniques economics, DNA genetics, Electric Conductivity, Electrochemical Techniques economics, Electrochemical Techniques instrumentation, Electrodes, Equipment Design, Biosensing Techniques instrumentation, DNA analysis, Metal Nanoparticles chemistry, Nucleic Acid Hybridization, Platinum chemistry
- Abstract
A novel nanoparticle based biosensor for the fast and simple detection of DNA hybridization events is presented. The sensor utilizes hybridized DNA's charge transport properties, combining them with metallic nanoparticle networks that act as nano-gapped electrodes. The DNA hybridization events can be detected by a significant reduction in the sensor's resistance due to the conductive bridging offered by hybridized DNA. By modifying the nanoparticle surface coverage, which can be controlled experimentally being a function of deposition time, and the structural properties of the electrodes, an optimized biosensor for the in situ detection of DNA hybridization events is ultimately fabricated. The fabricated biosensor exhibits a wide response range, covering four orders of magnitude, a limit of detection of 1nM and can detect a single base pair mismatch between probe and complementary DNA., (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
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