276 results on '"Spring, David R."'
Search Results
2. CK2 Inhibitors Targeting Inside and Outside the Catalytic Box
3. Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution
4. Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
5. Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
6. Finding New Components of the Target of Rapamycin (TOR) Signaling Network through Chemical Genetics and Proteome Chips
7. A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
8. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
9. A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction.
10. Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance
11. The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance
12. Identification of macrocyclic peptides which activate bacterial cylindrical proteases
13. A cell-active peptide targeting the Nrf2/Keap1 protein-protein interaction
14. Studies on the biomimetic synthesis of the manzamine alkaloids
15. Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions
16. Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation
17. Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons
18. Rapid and robust cysteine bioconjugation with vinylheteroarenes
19. All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading
20. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
21. A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium
22. Diversity-oriented synthesis of macrocyclic peptidomimetics
23. Variations on a theme: diverse N-acyl homoserine lactone-mediated quorum sensing mechanisms in Gram-negative bacteria
24. Additional file 1 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
25. Additional file 3 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
26. Additional file 2 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
27. Additional file 6 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
28. Additional file 5 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
29. Additional file 4 of Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
30. Structure-activity analysis of the Pseudomonas quinolone signal molecule
31. Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study
32. Rapid and robust cysteine bioconjugation with vinylheteroarenes
33. Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp
34. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction
35. Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorumsensing capacities
36. Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?
37. The Serratia LuxR family regulator CarR39006 activates transcription independently of cognate quorum sensing signals
38. Drug discovery: A question of library design: Two approaches have emerged for creating libraries of compounds for use in biological screening assays for drug discovery — fragment-based ligand design and diversity-oriented synthesis. Advocates of each approach discuss their favoured strategy.
39. 2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa
40. Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction
41. Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
42. Sulfatase-cleavable linkers for antibody-drug conjugates
43. Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
44. Stapled peptides as a new technology to investigate protein-protein interactions in human platelets
45. Second-generation CK2α inhibitors targeting the αD pocket
46. Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates
47. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction† †Electronic supplementary information (ESI) available: Computational methods and structure files, chemical synthesis, fluorescence polarization assays, crystallographic data. See DOI: 10.1039/c7cc05379g
48. Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes† †Electronic supplementary information (ESI) available: Synthetic protocols, 1H/13C NMR and HR mass spectra are provided. CCDC 1443618–1443620 and 1534812–1534815. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00964j Click here for additional data file. Click here for additional data file
49. Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst† †Dedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k Click here for additional data file
50. Stereocontrolled semi-syntheses of deguelin and tephrosin† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra. See DOI: 10.1039/c6ob02659a Click here for additional data file
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.