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8 results on '"Stritt, Manuel"'

1. NF-κB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model

Author

Sieber, Patrick, primary, Schäfer, Anny, additional, Lieberherr, Raphael, additional, Caimi, Silvia L., additional, Lüthi, Urs, additional, Ryge, Jesper, additional, Bergmann, Jan H., additional, Le Goff, François, additional, Stritt, Manuel, additional, Blattmann, Peter, additional, Renault, Bérengère, additional, Rammelt, Patrick, additional, Sempere, Bruno, additional, Freti, Diego, additional, Studer, Rolf, additional, White, Eric S., additional, Birker-Robaczewska, Magdalena, additional, Boucher, Maxime, additional, and Nayler, Oliver, additional

Published
2023
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3. Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots

Author

Fitzgerald, Seán, primary, Wang, Shunli, additional, Dai, Daying, additional, Murphree, Dennis H., additional, Pandit, Abhay, additional, Douglas, Andrew, additional, Rizvi, Asim, additional, Kadirvel, Ramanathan, additional, Gilvarry, Michael, additional, McCarthy, Ray, additional, Stritt, Manuel, additional, Gounis, Matthew J., additional, Brinjikji, Waleed, additional, Kallmes, David F., additional, and Doyle, Karen M., additional

Published
2019
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6. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor

Author

Lotz-Jenne, Carina, primary, Lüthi, Urs, additional, Ackerknecht, Sabine, additional, Lehembre, François, additional, Fink, Tobias, additional, Stritt, Manuel, additional, Wirth, Matthias, additional, Pavan, Simona, additional, Bill, Ruben, additional, Regenass, Urs, additional, Christofori, Gerhard, additional, and Meyer-Schaller, Nathalie, additional

Published
2016
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7. Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors.

Author

Sieber, Patrick, Schäfer, Anny, Lieberherr, Raphael, Le Goff, François, Stritt, Manuel, Welford, Richard W. D., Gatfield, John, Peter, Oliver, Nayler, Oliver, and Lüthi, Urs

Subjects
PULMONARY fibrosis, MYOFIBROBLASTS, EXTRACELLULAR matrix, CHEMICAL structure, MEDICAL screening
Abstract

Pathological features of pulmonary fibrosis include accumulation of myofibroblasts and increased extracellular matrix (ECM) deposition in lung tissue. Contractile α–smooth muscle actin (α–SMA)–expressing myofibroblasts that produce and secrete ECM are key effector cells of the disease and therefore represent a viable target for potential novel anti–fibrotic treatments. We used primary normal human lung fibroblasts (NHLF) in two novel high–throughput screening assays to discover molecules that inhibit or revert fibroblast–to–myofibroblast differentiation. A phenotypic high–content assay (HCA) quantified the degree of myofibroblast differentiation, whereas an impedance–based assay, multiplexed with MS / MS quantification of α–SMA and collagen 1 alpha 1 (COL1) protein, provided a measure of contractility and ECM formation. The synthetic prostaglandin E1 (PGE1) alprostadil, which very effectively and potently attenuated and even reversed TGF–β1–induced myofibroblast differentiation, was identified by screening a library of approved drugs. In TGF–β1–induced myofibroblasts the effect of alprostadil was attributed to activation of prostanoid receptor 2 and 4 (EP2 and EP4, respectively). However, selective activation of the EP2 or the EP4 receptor was already sufficient to prevent or reverse TGF–β1–induced NHLF myofibroblast transition. Our high–throughput assays identified chemical structures with potent anti–fibrotic properties acting through potentially novel mechanisms. [ABSTRACT FROM AUTHOR]

Published
2018
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8. Identification of Cathepsin L as a Potential Sex-Specific Biomarker for Renal Damage

Author

Bauer, Yasmina, primary, Hess, Patrick, additional, Qiu, Changbin, additional, Klenk, Axel, additional, Renault, Bérengère, additional, Wanner, Daniel, additional, Studer, Rolf, additional, Killer, Nina, additional, Stalder, Anna Katharina, additional, Stritt, Manuel, additional, Strasser, Daniel Stefan, additional, Farine, Hervé, additional, Kauser, Katalin, additional, Clozel, Martine, additional, Fischli, Walter, additional, and Nayler, Oliver, additional

Published
2011
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