Wang,Meimei, Zhang,Zhenzhen, Sun,Ning, Yang,Baolin, Mo,Jihao, Wang,Daping, Su,Mingqin, Hu,Jian, Wang,Miaomiao, Wang,Lei, Wang,Meimei, Zhang,Zhenzhen, Sun,Ning, Yang,Baolin, Mo,Jihao, Wang,Daping, Su,Mingqin, Hu,Jian, Wang,Miaomiao, and Wang,Lei
Meimei Wang,1,* Zhenzhen Zhang,2,* Ning Sun,3 Baolin Yang,4 Jihao Mo,5 Daping Wang,2 Mingqin Su,1 Jian Hu,1 Miaomiao Wang,6 Lei Wang7,8 1Department of Pathophysiology, School of Basic Medical Science, Anhui Medical University, Hefei, Anhui, 230032, Peopleâs Republic of China; 2Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, Peopleâs Republic of China; 3Institute of Clinical Laboratory Science, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, 210002, Peopleâs Republic of China; 4Institute of Technical Biology & Agriculture Engineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230032, Peopleâs Republic of China; 5Department of Medical Laboratory, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Institute of Henan Province, Luoyang, Henan, 459001, Peopleâs Republic of China; 6School of Medical Science, Huang He Science and Technology University, Zhengzhou, Henan, 459001, Peopleâs Republic of China; 7School of Biological Sciences, Nanyang Technological University, Singapore, 639798, Singapore; 8Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA*These authors contributed equally to this workCorrespondence: Lei Wang, Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA, Tel +1 786-620-1400, Email lxw561@miami.eduIntroduction: The increasing use of gold nanoparticles (Au NPs) in the medical field has raised concerns about the potential adverse effect of Au NPs exposure. However, it is difficult to assess the health risks of Au NPs exposure at the individual organ level using current measurement techniques.Methods: The physical and chemical properties of Au NPs were characterized by transmission electron microscope (TEM), Fourier transform infrared (FTIR), and zeta sizer. The RNA-seq data o